Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= Dr_sW_007_N15
(793 letters)
Database: Non-redundant SwissProt sequences
184,735 sequences; 68,354,980 total letters
Score E
Sequences producing significant alignments: (bits) Value
sp|O02485|YDJ1_CAEEL Hypothetical protein ZK1073.1 in chrom... 139 1e-32
sp|Q92597|NDRG1_HUMAN NDRG1 protein (N-myc downstream regul... 103 5e-22
sp|Q62433|NDRG1_MOUSE NDRG1 protein (N-myc downstream regul... 103 5e-22
sp|Q9UGV2|NDRG3_HUMAN NDRG3 protein 97 7e-20
sp|Q9UN36|NDRG2_HUMAN NDRG2 protein (Syld709613 protein) 95 2e-19
sp|Q9QYF9|NDRG3_MOUSE NDRG3 protein (Ndr3 protein) 92 1e-18
sp|Q9QYG0|NDRG2_MOUSE NDRG2 protein (Ndr2 protein) 92 2e-18
sp|Q9ULP0|NDRG4_HUMAN NDRG4 protein (Brain development-rela... 89 1e-17
sp|Q8BTG7|NDRG4_MOUSE NDRG4 protein 89 2e-17
sp|Q9Z2L9|NDRG4_RAT NDRG4 protein (Brain development-relate... 87 7e-17
>sp|O02485|YDJ1_CAEEL Hypothetical protein ZK1073.1 in chromosome X
Length = 325
Score = 139 bits (349), Expect = 1e-32
Identities = 84/263 (31%), Positives = 137/263 (52%), Gaps = 5/263 (1%)
Frame = +1
Query: 4 ILTVHDIGCNHTQYVDFIKHSCMETLAPRCVWFNVDLPGQGINDPDLPSDFTYPTMQQIA 183
ILTVHDIG NH +V F+ H M T+ + ++ +V +PGQ N D DF PT+ I
Sbjct: 36 ILTVHDIGTNHKSFVRFVNHPSMATVKEKAIFLHVCVPGQEDNSADFFGDF--PTLDGIG 93
Query: 184 EDLIECIGMLSISHLIVFGEGAGANILARMAMTGDERILGAVLLNCVGSTPNLVESLKDK 363
+DL + + I FGEG GANI+ R AM RI+G VL++C +T ++E K+K
Sbjct: 94 DDLSAVLDKFEVKSAIAFGEGVGANIICRFAMGHPNRIMGIVLVHCTSTTAGIIEYCKEK 153
Query: 364 IIGWKLSTIGMTSSTENYLVVHRFGVMNNLQSDEELSTMINNYKKFLRDTFNTKNLHGYV 543
++ +L M+ +YL+ H+FG + + + Y + L+ T N KNL Y+
Sbjct: 154 VMNMRLENSIMSDGAWDYLLAHKFGGESKSRQE---------YLEELKATLNPKNLSKYL 204
Query: 544 TSYMNRSNLIDKSMSIRCPM-----LFISGSLANYADDVKCLYEDIQGFLKNDPDRKRHI 708
++ R++L S +I + L ++GS A++ V ++ + K+
Sbjct: 205 VAFTKRTDL---SSTIGTKLETVDALLVTGSKASHLHTVYTTHKSM---------NKKKT 252
Query: 709 EFMEIDNCANVIVERTDQVAESL 777
+ +DN A+V+ E D++A SL
Sbjct: 253 TLLVVDNVADVMQEAPDKLARSL 275
>sp|Q92597|NDRG1_HUMAN NDRG1 protein (N-myc downstream regulated gene 1 protein)
(Differentiation-related gene 1 protein) (DRG1)
(Reducing agents and tunicamycin-responsive protein)
(RTP) (Nickel-specific induction protein Cap43) (Rit42)
Length = 394
Score = 103 bits (257), Expect = 5e-22
Identities = 77/272 (28%), Positives = 132/272 (48%), Gaps = 9/272 (3%)
Frame = +1
Query: 4 ILTVHDIGCNH-TQYVDFIKHSCMETLAPRCVWFNVDLPGQGINDPDLPSDFTYPTMQQI 180
ILT HDIG NH T Y + M+ + +VD PGQ P+ + YP+M Q+
Sbjct: 59 ILTYHDIGMNHKTCYNPLFNYEDMQEITQHFAVCHVDAPGQQDGAASFPAGYMYPSMDQL 118
Query: 181 AEDLIECIGMLSISHLIVFGEGAGANILARMAMTGDERILGAVLLNCVGSTPNLVESLKD 360
AE L + + +I G GAGA IL R A+ E + G VL+N ++
Sbjct: 119 AEMLPGVLQQFGLKSIIGMGTGAGAYILTRFALNNPEMVEGLVLINVNPCAEGWMDWAAS 178
Query: 361 KIIGWKLSTIGMTSSTENYLVVHRFGVMNNLQSDEELSTMINNYKKFLRDTFNTKNLHGY 540
KI GW T + + +V H FG +QS+ E +++ Y++ + + N NLH +
Sbjct: 179 KISGW-------TQALPDMVVSHLFG-KEEMQSNVE---VVHTYRQHIVNDMNPGNLHLF 227
Query: 541 VTSYMNRSNL-IDKSM------SIRCPMLFISGSLANYADDVKCLYEDIQGFLKNDPDRK 699
+ +Y +R +L I++ M +++CP L + G + D V ++ K DP +
Sbjct: 228 INAYNSRRDLEIERPMPGTHTVTLQCPALLVVGDSSPAVDAV------VECNSKLDPTK- 280
Query: 700 RHIEFMEIDNCANV-IVERTDQVAESLQYFLQ 792
+++ +C + + + ++AE+ +YF+Q
Sbjct: 281 --TTLLKMADCGGLPQISQPAKLAEAFKYFVQ 310
>sp|Q62433|NDRG1_MOUSE NDRG1 protein (N-myc downstream regulated gene 1 protein) (Protein
Ndr1)
Length = 394
Score = 103 bits (257), Expect = 5e-22
Identities = 77/275 (28%), Positives = 132/275 (48%), Gaps = 12/275 (4%)
Frame = +1
Query: 4 ILTVHDIGCNH-TQYVDFIKHSCMETLAPRCVWFNVDLPGQGINDPDLPSDFTYPTMQQI 180
ILT HDIG NH T Y M+ + +VD PGQ P P + YP+M Q+
Sbjct: 59 ILTYHDIGMNHKTCYNPLFNSEDMQEITQHFAVCHVDAPGQQDGAPSFPVGYMYPSMDQL 118
Query: 181 AEDLIECIGMLSISHLIVFGEGAGANILARMAMTGDERILGAVLLNCVGSTPNLVESLKD 360
AE L + + +I G GAGA IL R A+ E + G VL+N ++
Sbjct: 119 AEMLPGVLHQFGLKSVIGMGTGAGAYILTRFALNNPEMVEGLVLMNVNPCAEGWMDWAAS 178
Query: 361 KIIGWKLSTIGMTSSTENYLVVHRFG---VMNNLQSDEELSTMINNYKKFLRDTFNTKNL 531
KI GW T + + +V H FG + NN++ +++ Y++ + + N NL
Sbjct: 179 KISGW-------TQALPDMVVSHLFGKEEIHNNVE-------VVHTYRQHILNDMNPSNL 224
Query: 532 HGYVTSYMNRSNL-IDKSM------SIRCPMLFISGSLANYADDVKCLYEDIQGFLKNDP 690
H ++++Y +R +L I++ M +++CP L + G + D V ++ K DP
Sbjct: 225 HLFISAYNSRRDLEIERPMPGTHTVTLQCPALLVVGDNSPAVDAV------VECNSKLDP 278
Query: 691 DRKRHIEFMEIDNCANV-IVERTDQVAESLQYFLQ 792
+ +++ +C + + + ++AE+ +YF+Q
Sbjct: 279 TK---TTLLKMADCGGLPQISQPAKLAEAFKYFVQ 310
>sp|Q9UGV2|NDRG3_HUMAN NDRG3 protein
Length = 375
Score = 96.7 bits (239), Expect = 7e-20
Identities = 76/275 (27%), Positives = 127/275 (46%), Gaps = 12/275 (4%)
Frame = +1
Query: 4 ILTVHDIGCNHTQYVD-FIKHSCMETLAPRCVWFNVDLPGQGINDPDLPSDFTYPTMQQI 180
ILT HDIG NH + F M+ + +VD PGQ P P+ + YPTM ++
Sbjct: 57 ILTYHDIGLNHKSCFNAFFNFEDMQEITQHFAVCHVDAPGQQEGAPSFPTGYQYPTMDEL 116
Query: 181 AEDLIECIGMLSISHLIVFGEGAGANILARMAMTGDERILGAVLLNCVGSTPNLVESLKD 360
AE L + LS+ +I G GAGA IL+R A+ E + G VL+N V+
Sbjct: 117 AEMLPPVLTHLSLKSIIGIGVGAGAYILSRFALNHPELVEGLVLIN--------VDPCAK 168
Query: 361 KIIGWKLSTI-GMTSSTENYLVVHRFGVMNNLQSDEELSTMINNYKKFLRDTFNTKNLHG 537
I W S + G+T++ + ++ H FG LQ++ +L I Y+ + N NL
Sbjct: 169 GWIDWAASKLSGLTTNVVDIILAHHFG-QEELQANLDL---IQTYRMHIAQDINQDNLQL 224
Query: 538 YVTSYMNRSNL----------IDKSMSIRCPMLFISGSLANYADDVKCLYEDIQGFLKND 687
++ SY R +L +KS +++C L + G D+ + ++ + +
Sbjct: 225 FLNSYNGRRDLEIERPILGQNDNKSKTLKCSTLLVVG------DNSPAVEAVVECNSRLN 278
Query: 688 PDRKRHIEFMEIDNCANVIVERTDQVAESLQYFLQ 792
P ++ + V+ + ++ E+ +YFLQ
Sbjct: 279 PINTTLLKMADCGGLPQVV--QPGKLTEAFKYFLQ 311
>sp|Q9UN36|NDRG2_HUMAN NDRG2 protein (Syld709613 protein)
Length = 371
Score = 94.7 bits (234), Expect = 2e-19
Identities = 78/272 (28%), Positives = 129/272 (47%), Gaps = 8/272 (2%)
Frame = +1
Query: 1 AILTVHDIGCNHTQ-YVDFIKHSCMETLAPRCVWFNVDLPGQGINDPDLPSDFTYPTMQQ 177
AILT HD+G N+ + + M+ + V +VD PG P P + YP++ Q
Sbjct: 64 AILTYHDVGLNYKSCFQPLFQFEDMQEIIQNFVRVHVDAPGMEEGAPVFPLGYQYPSLDQ 123
Query: 178 IAEDLIECI-GMLSISHLIVFGEGAGANILARMAMTGDERILGAVLLNCVGSTPNLVESL 354
+A D+I C+ L+ S +I G GAGA ILAR A+ + + G VL+N + ++
Sbjct: 124 LA-DMIPCVLQYLNFSTIIGVGVGAGAYILARYALNHPDTVEGLVLINIDPNAKGWMDWA 182
Query: 355 KDKIIGWKLSTIGMTSSTENYLVVHRFGVMNNLQSDEEL---STMINNYKKFLRDTFNTK 525
K+ G+TSS ++ H F S EEL S +I Y+ + N
Sbjct: 183 AHKL-------TGLTSSIPEMILGHLF-------SQEELSGNSELIQKYRNIITHAPNLD 228
Query: 526 NLHGYVTSYMNRSNLIDK---SMSIRCPMLFISGSLANYADDVKCLYEDIQGFLKNDPDR 696
N+ Y SY NR +L + +++RCP++ + G A + D V ++ K DP +
Sbjct: 229 NIELYWNSYNNRRDLNFERGGDITLRCPVMLVVGDQAPHEDAV------VECNSKLDPTQ 282
Query: 697 KRHIEFMEIDNCANVIVERTDQVAESLQYFLQ 792
++ D+ + + ++ E+ +YFLQ
Sbjct: 283 TSFLKM--ADSGGQPQLTQPGKLTEAFKYFLQ 312
>sp|Q9QYF9|NDRG3_MOUSE NDRG3 protein (Ndr3 protein)
Length = 375
Score = 92.4 bits (228), Expect = 1e-18
Identities = 74/275 (26%), Positives = 126/275 (45%), Gaps = 12/275 (4%)
Frame = +1
Query: 4 ILTVHDIGCNHTQ-YVDFIKHSCMETLAPRCVWFNVDLPGQGINDPDLPSDFTYPTMQQI 180
ILT HDIG NH + F M+ + +VD PGQ P P+ + YPTM ++
Sbjct: 57 ILTYHDIGLNHKSCFNTFFNFEDMQEITQHFAVCHVDAPGQQEAAPSFPTGYQYPTMDEL 116
Query: 181 AEDLIECIGMLSISHLIVFGEGAGANILARMAMTGDERILGAVLLNCVGSTPNLVESLKD 360
AE L + LS+ +I G GAGA IL+R A+ E + G VL+N ++
Sbjct: 117 AEMLPPVLTHLSMKSIIGIGVGAGAYILSRFALNHPELVEGLVLIN--------IDPCAK 168
Query: 361 KIIGWKLSTI-GMTSSTENYLVVHRFGVMNNLQSDEELSTMINNYKKFLRDTFNTKNLHG 537
I W S + G T++ + ++ H FG LQ++ +L I Y+ + N +NL
Sbjct: 169 GWIDWAASKLSGFTTNIVDIILAHHFG-QEELQANLDL---IQTYRLHIAQDINQENLQL 224
Query: 538 YVTSYMNRSNL----------IDKSMSIRCPMLFISGSLANYADDVKCLYEDIQGFLKND 687
++ SY R +L ++ +++C L + G D+ + ++ + D
Sbjct: 225 FLGSYNGRRDLEIERPILGQNDNRLKTLKCSTLLVVG------DNSPAVEAVVECNSRLD 278
Query: 688 PDRKRHIEFMEIDNCANVIVERTDQVAESLQYFLQ 792
P ++ + V+ + ++ E+ +YFLQ
Sbjct: 279 PINTTLLKMADCGGLPQVV--QPGKLTEAFKYFLQ 311
>sp|Q9QYG0|NDRG2_MOUSE NDRG2 protein (Ndr2 protein)
Length = 371
Score = 92.0 bits (227), Expect = 2e-18
Identities = 76/272 (27%), Positives = 130/272 (47%), Gaps = 8/272 (2%)
Frame = +1
Query: 1 AILTVHDIGCNHTQ-YVDFIKHSCMETLAPRCVWFNVDLPGQGINDPDLPSDFTYPTMQQ 177
AI T HD+G N+ + + M+ + V +VD PG P P + YP++ Q
Sbjct: 64 AIFTYHDVGLNYKSCFQPLFRFGDMQEIIQNFVRVHVDAPGMEEGAPVFPLGYQYPSLDQ 123
Query: 178 IAEDLIECI-GMLSISHLIVFGEGAGANILARMAMTGDERILGAVLLNCVGSTPNLVESL 354
+A D+I CI L+ S +I G GAGA IL+R A+ + + G VL+N + ++
Sbjct: 124 LA-DMIPCILQYLNFSTIIGVGVGAGAYILSRYALNHPDTVEGLVLINIDPNAKGWMDWA 182
Query: 355 KDKIIGWKLSTIGMTSSTENYLVVHRFGVMNNLQSDEEL---STMINNYKKFLRDTFNTK 525
K+ G+TSS + ++ H F S EEL S +I Y+ ++ N +
Sbjct: 183 AHKL-------TGLTSSIPDMILGHLF-------SQEELSGNSELIQKYRGIIQHAPNLE 228
Query: 526 NLHGYVTSYMNRSNLIDK---SMSIRCPMLFISGSLANYADDVKCLYEDIQGFLKNDPDR 696
N+ Y SY NR +L + +++CP++ + G A + D V ++ K DP +
Sbjct: 229 NIELYWNSYNNRRDLNFERGGETTLKCPVMLVVGDQAPHEDAV------VECNSKLDPTQ 282
Query: 697 KRHIEFMEIDNCANVIVERTDQVAESLQYFLQ 792
++ D+ + + ++ E+ +YFLQ
Sbjct: 283 TSFLKM--ADSGGQPQLTQPGKLTEAFKYFLQ 312
>sp|Q9ULP0|NDRG4_HUMAN NDRG4 protein (Brain development-related molecule 1) (Vascular
smooth muscle cell associated protein 8) (SMAP-8)
Length = 352
Score = 89.4 bits (220), Expect = 1e-17
Identities = 69/275 (25%), Positives = 125/275 (45%), Gaps = 11/275 (4%)
Frame = +1
Query: 1 AILTVHDIGCNHTQ-YVDFIKHSCMETLAPRCVWFNVDLPGQGINDPDLPSDFTYPTMQQ 177
AILT HD+G NH + F M+ + V +VD PGQ + P + +P+M+Q
Sbjct: 32 AILTYHDVGLNHKLCFNTFFNFEDMQEITKHFVVCHVDAPGQQVGASQFPQGYQFPSMEQ 91
Query: 178 IAEDLIECIGMLSISHLIVFGEGAGANILARMAMTGDERILGAVLLNCVGSTPNLVESLK 357
+A L + ++I G GAGA +LA+ A+ + + G VL+N + ++
Sbjct: 92 LAAMLPSVVQHFGFKYVIGIGVGAGAYVLAKFALIFPDLVEGLVLVNIDPNGKGWIDWAA 151
Query: 358 DKIIGWKLSTIGMTSSTENYLVVHRFGVMNNLQSDEEL---STMINNYKKFLRDTFNTKN 528
K+ G+TS+ + ++ H F S EEL + ++ +Y++ + + N N
Sbjct: 152 TKL-------SGLTSTLPDTVLSHLF-------SQEELVNNTELVQSYRQQIGNVVNQAN 197
Query: 529 LHGYVTSY-------MNRSNLIDKSMSIRCPMLFISGSLANYADDVKCLYEDIQGFLKND 687
L + Y +NR + + ++RCP++ + G A D V ++ K D
Sbjct: 198 LQLFWNMYNSRRDLDINRPGTVPNAKTLRCPVMLVVGDNAPAEDGV------VECNSKLD 251
Query: 688 PDRKRHIEFMEIDNCANVIVERTDQVAESLQYFLQ 792
P ++ + V + ++ E+ +YFLQ
Sbjct: 252 PTTTTFLKMADSGGLPQ--VTQPGKLTEAFKYFLQ 284
>sp|Q8BTG7|NDRG4_MOUSE NDRG4 protein
Length = 352
Score = 88.6 bits (218), Expect = 2e-17
Identities = 68/275 (24%), Positives = 125/275 (45%), Gaps = 11/275 (4%)
Frame = +1
Query: 1 AILTVHDIGCNHTQ-YVDFIKHSCMETLAPRCVWFNVDLPGQGINDPDLPSDFTYPTMQQ 177
AILT HD+G NH + F M+ + V +VD PGQ + P + +P+M+Q
Sbjct: 32 AILTYHDVGLNHKLCFNTFFNFEDMQEITKHFVVCHVDAPGQQVGASQFPQGYQFPSMEQ 91
Query: 178 IAEDLIECIGMLSISHLIVFGEGAGANILARMAMTGDERILGAVLLNCVGSTPNLVESLK 357
+A L + ++I G GAGA +LA+ A+ + + G VL+N + ++
Sbjct: 92 LAAMLPSVVQHFGFKYVIGIGVGAGAYVLAKFALIFPDLVEGLVLMNIDPNGKGWIDWAA 151
Query: 358 DKIIGWKLSTIGMTSSTENYLVVHRFGVMNNLQSDEEL---STMINNYKKFLRDTFNTKN 528
K+ G+TS+ + ++ H F S EEL + ++ +Y++ + + N N
Sbjct: 152 TKL-------SGLTSTLPDTVLSHLF-------SQEELVNNTELVQSYRQQISNVVNQAN 197
Query: 529 LHGYVTSY-------MNRSNLIDKSMSIRCPMLFISGSLANYADDVKCLYEDIQGFLKND 687
L + Y +NR + + ++RCP++ + G A + V ++ K D
Sbjct: 198 LQLFWNMYNSRRDLDINRPGTVPNAKTLRCPVMLVVGDNAPAEEGV------VECNSKLD 251
Query: 688 PDRKRHIEFMEIDNCANVIVERTDQVAESLQYFLQ 792
P ++ + V + ++ E+ +YFLQ
Sbjct: 252 PTTTTFLKMADSGGLPQ--VTQPGKLTEAFKYFLQ 284
>sp|Q9Z2L9|NDRG4_RAT NDRG4 protein (Brain development-related molecule 1)
Length = 352
Score = 86.7 bits (213), Expect = 7e-17
Identities = 68/275 (24%), Positives = 125/275 (45%), Gaps = 11/275 (4%)
Frame = +1
Query: 1 AILTVHDIGCNHTQYVDFIKH-SCMETLAPRCVWFNVDLPGQGINDPDLPSDFTYPTMQQ 177
AILT HD+G NH + + + M+ + V +VD PGQ + P + +P+M+Q
Sbjct: 32 AILTYHDVGLNHKLCFNTLFNLEDMQEITKHFVVCHVDAPGQQVGASQFPQGYQFPSMEQ 91
Query: 178 IAEDLIECIGMLSISHLIVFGEGAGANILARMAMTGDERILGAVLLNCVGSTPNLVESLK 357
+A L + ++I G GAGA +LA+ A+ + + G VL+N + ++
Sbjct: 92 LATMLPNVVQHFGFKYVIGIGVGAGAYVLAKFALIFPDLVEGLVLMNIDPNGKGWIDWAA 151
Query: 358 DKIIGWKLSTIGMTSSTENYLVVHRFGVMNNLQSDEEL---STMINNYKKFLRDTFNTKN 528
K+ G+TS+ + ++ H F S EEL + ++ +Y++ + N N
Sbjct: 152 TKL-------SGLTSTLPDTVLSHLF-------SQEELVNNTELVQSYRQQISSVVNQAN 197
Query: 529 LHGYVTSY-------MNRSNLIDKSMSIRCPMLFISGSLANYADDVKCLYEDIQGFLKND 687
L + Y +NR + + ++RCP++ + G A D V ++ K D
Sbjct: 198 LQLFWNMYNSRRDLDINRPGTVPNAKTLRCPVMLVVGDNAPAEDGV------VECNSKLD 251
Query: 688 PDRKRHIEFMEIDNCANVIVERTDQVAESLQYFLQ 792
P ++ + V + ++ E+ +YFLQ
Sbjct: 252 PTTTTFLKMADSGGLPQ--VTQPGKLTEAFKYFLQ 284
Database: Non-redundant SwissProt sequences
Posted date: Dec 6, 2005 7:40 AM
Number of letters in database: 68,354,980
Number of sequences in database: 184,735
Database: swissprot.01
Posted date: Dec 6, 2005 8:18 AM
Number of letters in database: 66,202,850
Number of sequences in database: 184,431
Lambda K H
0.318 0.134 0.401
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 90,335,771
Number of Sequences: 369166
Number of extensions: 1844902
Number of successful extensions: 4957
Number of sequences better than 10.0: 10
Number of HSP's better than 10.0 without gapping: 4784
Number of HSP's successfully gapped in prelim test: 0
Number of HSP's that attempted gapping in prelim test: 0
Number of HSP's gapped (non-prelim): 4942
length of database: 68,354,980
effective HSP length: 109
effective length of database: 48,218,865
effective search space used: 7425705210
frameshift window, decay const: 40, 0.1
T: 12
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)