Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= Dr_sW_007_M06
(734 letters)
Database: Non-redundant SwissProt sequences
184,735 sequences; 68,354,980 total letters
Score E
Sequences producing significant alignments: (bits) Value
sp|Q24940|CATLP_FASHE Cathepsin L-like proteinase precursor 201 2e-51
sp|Q9JIA9|CATR_MOUSE Cathepsin R precursor 174 2e-43
sp|O60911|CATL2_HUMAN Cathepsin L2 precursor (Cathepsin V) ... 172 6e-43
sp|Q9GL24|CATL_CANFA Cathepsin L precursor [Contains: Cathe... 172 6e-43
sp|P07711|CATL_HUMAN Cathepsin L precursor (Major excreted ... 172 8e-43
sp|P61277|CATK_MACMU Cathepsin K precursor >gi|47117667|sp|... 172 1e-42
sp|P43235|CATK_HUMAN Cathepsin K precursor (Cathepsin O) (C... 171 1e-42
sp|P06797|CATL_MOUSE Cathepsin L precursor (Major excreted ... 171 2e-42
sp|Q9R014|CATJ_MOUSE Cathepsin J precursor (Cathepsin P) (C... 170 4e-42
sp|Q8HY82|CATS_SAIBB Cathepsin S precursor 170 4e-42
>sp|Q24940|CATLP_FASHE Cathepsin L-like proteinase precursor
Length = 326
Score = 201 bits (510), Expect = 2e-51
Identities = 98/243 (40%), Positives = 153/243 (62%), Gaps = 2/243 (0%)
Frame = +2
Query: 2 LSLFVVSHATLHQPTTNAQLNNEWKAFKLLFKKEYEPIDEVVRRLIWEENLRYIQKHNLE 181
+ LF+++ T+ +N L ++WK ++ KEY D+ RR IWE+N+++IQ+HNL
Sbjct: 1 MRLFILAVLTVGVLGSNDDLWHQWKR---MYNKEYNGADDQHRRNIWEKNVKHIQEHNLR 57
Query: 182 ADLGKHTFTLGLNQFADLTNEEFRSKYLSKNLMSRSQINSKFVMPYKT--KLNDDEVDWR 355
DLG T+TLGLNQF D+T EEF++KYL++ MSR+ +PY+ + D++DWR
Sbjct: 58 HDLGLVTYTLGLNQFTDMTFEEFKAKYLTE--MSRASDILSHGVPYEANNRAVPDKIDWR 115
Query: 356 KKGVVTPVKNQYGCNAGWAFAATGSCEGRYAMQTGVLMSFSEEQLIDCSDAYGNSGCKGG 535
+ G VT VK+Q C + WAF+ TG+ EG+Y +SFSE+QL+DCS +GN+GC GG
Sbjct: 116 ESGYVTEVKDQGNCGSCWAFSTTGTMEGQYMKNERTSISFSEQQLVDCSGPWGNNGCSGG 175
Query: 536 SPDNSFNYYKPYGMNNEETYPYFGIKDRCKYNNNSVIAHVVSFIDVARNNEIQVAAAVSA 715
+N++ Y K +G+ E +YPY ++ +C+YN +A V + V +E+++ V A
Sbjct: 176 LMENAYQYLKQFGLETESSYPYTAVEGQCRYNKQLGVAKVTGYYTVHSGSEVELKNLVGA 235
Query: 716 EGP 724
P
Sbjct: 236 RRP 238
>sp|Q9JIA9|CATR_MOUSE Cathepsin R precursor
Length = 334
Score = 174 bits (442), Expect = 2e-43
Identities = 91/233 (39%), Positives = 139/233 (59%), Gaps = 2/233 (0%)
Frame = +2
Query: 41 PTTNAQLNNEWKAFKLLFKKEYEPIDEVVRRLIWEENLRYIQKHNLEADLGKHTFTLGLN 220
P ++ L+ EW+ +K+ + K Y +E ++R++WEE L+ I+ HN E LGK+ FT+ +N
Sbjct: 19 PVLDSSLDAEWQDWKIKYNKSYSLKEEKLKRVVWEEKLKMIKLHNRENSLGKNGFTMKMN 78
Query: 221 QFADLTNEEFRSKYLSKNLMSRSQINSKFVMPYKT-KLNDDEVDWRKKGVVTPVKNQYGC 397
+F D T+EEFR + ++ + + K +M + + VDWRKKG VTPV+ Q C
Sbjct: 79 EFGDQTDEEFRKMMIEISVWTHRE--GKSIMKREAGSILPKFVDWRKKGYVTPVRRQGDC 136
Query: 398 NAGWAFAATGSCEGRYAMQTGVLMSFSEEQLIDCSDAYGNSGCKGGSPDNSFNY-YKPYG 574
+A WAFA TG+ E + QTG L S + L+DCS GN+GC GG N+F Y G
Sbjct: 137 DACWAFAVTGAIEAQAIWQTGKLTPLSVQNLVDCSKPQGNNGCLGGDTYNAFQYVLHNGG 196
Query: 575 MNNEETYPYFGIKDRCKYNNNSVIAHVVSFIDVARNNEIQVAAAVSAEGPLTA 733
+ +E TYPY G C+YN + A + F+ + ++ +I + AAV+ GP+TA
Sbjct: 197 LESEATYPYEGKDGPCRYNPKNSKAEITGFVSLPQSEDI-LMAAVATIGPITA 248
>sp|O60911|CATL2_HUMAN Cathepsin L2 precursor (Cathepsin V) (Cathepsin U)
Length = 334
Score = 172 bits (437), Expect = 6e-43
Identities = 94/232 (40%), Positives = 132/232 (56%), Gaps = 2/232 (0%)
Frame = +2
Query: 41 PTTNAQLNNEWKAFKLLFKKEYEPIDEVVRRLIWEENLRYIQKHNLEADLGKHTFTLGLN 220
P + L+ +W +K ++ Y +E RR +WE+N++ I+ HN E GKH FT+ +N
Sbjct: 19 PKFDQNLDTKWYQWKATHRRLYGANEEGWRRAVWEKNMKMIELHNGEYSQGKHGFTMAMN 78
Query: 221 QFADLTNEEFRSKY-LSKNLMSRSQINSKFVMPYKTKLNDDEVDWRKKGVVTPVKNQYGC 397
F D+TNEEFR +N R F P L VDWRKKG VTPVKNQ C
Sbjct: 79 AFGDMTNEEFRQMMGCFRNQKFRK--GKVFREPLFLDL-PKSVDWRKKGYVTPVKNQKQC 135
Query: 398 NAGWAFAATGSCEGRYAMQTGVLMSFSEEQLIDCSDAYGNSGCKGGSPDNSFNYYKPY-G 574
+ WAF+ATG+ EG+ +TG L+S SE+ L+DCS GN GC GG +F Y K G
Sbjct: 136 GSCWAFSATGALEGQMFRKTGKLVSLSEQNLVDCSRPQGNQGCNGGFMARAFQYVKENGG 195
Query: 575 MNNEETYPYFGIKDRCKYNNNSVIAHVVSFIDVARNNEIQVAAAVSAEGPLT 730
+++EE+YPY + + CKY + +A+ F VA E + AV+ GP++
Sbjct: 196 LDSEESYPYVAVDEICKYRPENSVANDTGFTVVAPGKEKALMKAVATVGPIS 247
>sp|Q9GL24|CATL_CANFA Cathepsin L precursor [Contains: Cathepsin L heavy chain; Cathepsin
L light chain]
Length = 333
Score = 172 bits (437), Expect = 6e-43
Identities = 93/232 (40%), Positives = 137/232 (59%), Gaps = 2/232 (0%)
Frame = +2
Query: 41 PTTNAQLNNEWKAFKLLFKKEYEPIDEVVRRLIWEENLRYIQKHNLEADLGKHTFTLGLN 220
P + LN +W +K ++ Y +E RR +WE+N++ I+ HN E GKH FT+ +N
Sbjct: 19 PKFDQSLNAQWYQWKATHRRLYGMNEEGWRRAVWEKNMKMIELHNREYSQGKHGFTMAMN 78
Query: 221 QFADLTNEEFRSKYLSKNLMSRSQINSKFVMPYKTKLNDDEVDWRKKGVVTPVKNQYGCN 400
F D+TNEEFR + ++ + + F P ++ VDWR+KG VTPVKNQ C
Sbjct: 79 AFGDMTNEEFR-QVMNGFQNQKHKKGKMFQEPLFAEI-PKSVDWREKGYVTPVKNQGQCG 136
Query: 401 AGWAFAATGSCEGRYAMQTGVLMSFSEEQLIDCSDAYGNSGCKGGSPDNSFNYYKPY-GM 577
+ WAF+ATG+ EG+ +TG L+S SE+ L+DCS A GN GC GG DN+F Y K G+
Sbjct: 137 SCWAFSATGALEGQMFRKTGKLVSLSEQNLVDCSRAQGNEGCNGGLMDNAFRYVKDNGGL 196
Query: 578 NNEETYPYFG-IKDRCKYNNNSVIAHVVSFIDVARNNEIQVAAAVSAEGPLT 730
++EE+YPY G + C Y A+ F+D+ + E + AV+ GP++
Sbjct: 197 DSEESYPYLGRDTETCNYKPECSAANDTGFVDLPQ-REKALMKAVATLGPIS 247
>sp|P07711|CATL_HUMAN Cathepsin L precursor (Major excreted protein) (MEP) [Contains:
Cathepsin L heavy chain; Cathepsin L light chain]
Length = 333
Score = 172 bits (436), Expect = 8e-43
Identities = 92/239 (38%), Positives = 138/239 (57%), Gaps = 1/239 (0%)
Frame = +2
Query: 17 VSHATLHQPTTNAQLNNEWKAFKLLFKKEYEPIDEVVRRLIWEENLRYIQKHNLEADLGK 196
++ ATL T + L +W +K + + Y +E RR +WE+N++ I+ HN E GK
Sbjct: 14 IASATL---TFDHSLEAQWTKWKAMHNRLYGMNEEGWRRAVWEKNMKMIELHNQEYREGK 70
Query: 197 HTFTLGLNQFADLTNEEFRSKYLSKNLMSRSQINSKFVMPYKTKLNDDEVDWRKKGVVTP 376
H+FT+ +N F D+T+EEFR + +R K VDWR+KG VTP
Sbjct: 71 HSFTMAMNAFGDMTSEEFRQ--VMNGFQNRKPRKGKVFQEPLFYEAPRSVDWREKGYVTP 128
Query: 377 VKNQYGCNAGWAFAATGSCEGRYAMQTGVLMSFSEEQLIDCSDAYGNSGCKGGSPDNSFN 556
VKNQ C + WAF+ATG+ EG+ +TG L+S SE+ L+DCS GN GC GG D +F
Sbjct: 129 VKNQGQCGSCWAFSATGALEGQMFRKTGRLISLSEQNLVDCSGPQGNEGCNGGLMDYAFQ 188
Query: 557 YYKPY-GMNNEETYPYFGIKDRCKYNNNSVIAHVVSFIDVARNNEIQVAAAVSAEGPLT 730
Y + G+++EE+YPY ++ CKYN +A+ F+D+ + E + AV+ GP++
Sbjct: 189 YVQDNGGLDSEESYPYEATEESCKYNPKYSVANDTGFVDIPK-QEKALMKAVATVGPIS 246
>sp|P61277|CATK_MACMU Cathepsin K precursor
sp|P61276|CATK_MACFA Cathepsin K precursor
Length = 329
Score = 172 bits (435), Expect = 1e-42
Identities = 92/227 (40%), Positives = 131/227 (57%), Gaps = 3/227 (1%)
Frame = +2
Query: 59 LNNEWKAFKLLFKKEYEP-IDEVVRRLIWEENLRYIQKHNLEADLGKHTFTLGLNQFADL 235
L+ W+ +K +K+Y +DE+ RRLIWE+NL+YI HNLEA LG HT+ L +N D+
Sbjct: 22 LDTHWELWKKTHRKQYNSKVDEISRRLIWEKNLKYISIHNLEASLGVHTYELAMNHLGDM 81
Query: 236 TNEEFRSKYLS-KNLMSRSQINSKFVMPYKTKLNDDEVDWRKKGVVTPVKNQYGCNAGWA 412
TNEE K K S S+ N +P D VD+RKKG VTPVKNQ C + WA
Sbjct: 82 TNEEVVQKMTGLKVPASHSRSNDTLYIPDWEGRAPDSVDYRKKGYVTPVKNQGQCGSCWA 141
Query: 413 FAATGSCEGRYAMQTGVLMSFSEEQLIDCSDAYGNSGCKGGSPDNSFNY-YKPYGMNNEE 589
F++ G+ EG+ +TG L++ S + L+DC N GC GG N+F Y K G+++E+
Sbjct: 142 FSSVGALEGQLKKKTGKLLNLSPQNLVDCVSE--NDGCGGGYMTNAFQYVQKNRGIDSED 199
Query: 590 TYPYFGIKDRCKYNNNSVIAHVVSFIDVARNNEIQVAAAVSAEGPLT 730
YPY G ++ C YN A + ++ NE + AV+ GP++
Sbjct: 200 AYPYVGQEESCMYNPTGKAAKCRGYREIPEGNEKALKRAVARVGPVS 246
>sp|P43235|CATK_HUMAN Cathepsin K precursor (Cathepsin O) (Cathepsin X) (Cathepsin O2)
Length = 329
Score = 171 bits (434), Expect = 1e-42
Identities = 90/227 (39%), Positives = 132/227 (58%), Gaps = 3/227 (1%)
Frame = +2
Query: 59 LNNEWKAFKLLFKKEYE-PIDEVVRRLIWEENLRYIQKHNLEADLGKHTFTLGLNQFADL 235
L+ W+ +K +K+Y +DE+ RRLIWE+NL+YI HNLEA LG HT+ L +N D+
Sbjct: 22 LDTHWELWKKTHRKQYNNKVDEISRRLIWEKNLKYISIHNLEASLGVHTYELAMNHLGDM 81
Query: 236 TNEEFRSKYLSKNL-MSRSQINSKFVMPYKTKLNDDEVDWRKKGVVTPVKNQYGCNAGWA 412
T+EE K + +S S+ N +P D VD+RKKG VTPVKNQ C + WA
Sbjct: 82 TSEEVVQKMTGLKVPLSHSRSNDTLYIPEWEGRAPDSVDYRKKGYVTPVKNQGQCGSCWA 141
Query: 413 FAATGSCEGRYAMQTGVLMSFSEEQLIDCSDAYGNSGCKGGSPDNSFNY-YKPYGMNNEE 589
F++ G+ EG+ +TG L++ S + L+DC N GC GG N+F Y K G+++E+
Sbjct: 142 FSSVGALEGQLKKKTGKLLNLSPQNLVDCVSE--NDGCGGGYMTNAFQYVQKNRGIDSED 199
Query: 590 TYPYFGIKDRCKYNNNSVIAHVVSFIDVARNNEIQVAAAVSAEGPLT 730
YPY G ++ C YN A + ++ NE + AV+ GP++
Sbjct: 200 AYPYVGQEESCMYNPTGKAAKCRGYREIPEGNEKALKRAVARVGPVS 246
>sp|P06797|CATL_MOUSE Cathepsin L precursor (Major excreted protein) (MEP) (p39 cysteine
proteinase) [Contains: Cathepsin L heavy chain;
Cathepsin L light chain]
Length = 334
Score = 171 bits (432), Expect = 2e-42
Identities = 93/234 (39%), Positives = 136/234 (58%), Gaps = 1/234 (0%)
Frame = +2
Query: 32 LHQPTTNAQLNNEWKAFKLLFKKEYEPIDEVVRRLIWEENLRYIQKHNLEADLGKHTFTL 211
L P + + EW +K ++ Y +E RR IWE+N+R IQ HN E G+H F++
Sbjct: 16 LATPKFDQTFSAEWHQWKSTHRRLYGTNEEEWRRAIWEKNMRMIQLHNGEYSNGQHGFSM 75
Query: 212 GLNQFADLTNEEFRSKYLSKNLMSRSQINSKFVMPYKTKLNDDEVDWRKKGVVTPVKNQY 391
+N F D+TNEEFR + ++ + + F P K+ VDWR+KG VTPVKNQ
Sbjct: 76 EMNAFGDMTNEEFR-QVVNGYRHQKHKKGRLFQEPLMLKI-PKSVDWREKGCVTPVKNQG 133
Query: 392 GCNAGWAFAATGSCEGRYAMQTGVLMSFSEEQLIDCSDAYGNSGCKGGSPDNSFNYYKPY 571
C + WAF+A+G EG+ ++TG L+S SE+ L+DCS A GN GC GG D +F Y K
Sbjct: 134 QCGSCWAFSASGCLEGQMFLKTGKLISLSEQNLVDCSHAQGNQGCNGGLMDFAFQYIKEN 193
Query: 572 -GMNNEETYPYFGIKDRCKYNNNSVIAHVVSFIDVARNNEIQVAAAVSAEGPLT 730
G+++EE+YPY CKY +A+ F+D+ + E + AV+ GP++
Sbjct: 194 GGLDSEESYPYEAKDGSCKYRAEFAVANDTGFVDIPQ-QEKALMKAVATVGPIS 246
>sp|Q9R014|CATJ_MOUSE Cathepsin J precursor (Cathepsin P) (Catlrp-p)
Length = 333
Score = 170 bits (430), Expect = 4e-42
Identities = 92/241 (38%), Positives = 139/241 (57%), Gaps = 1/241 (0%)
Frame = +2
Query: 14 VVSHATLHQPTTNAQLNNEWKAFKLLFKKEYEPIDEVVRRLIWEENLRYIQKHNLEADLG 193
V S A H P +L+ EWK +K + K Y P +E +RR +WEEN+R I+ HN E LG
Sbjct: 14 VASGAQAHDP----KLDAEWKDWKTKYAKSYSP-EEALRRAVWEENMRMIKLHNKENSLG 68
Query: 194 KHTFTLGLNQFADLTNEEFRSKYLSKNLMSRSQINSKFVMPYKTKLNDDEVDWRKKGVVT 373
K+ FT+ +N+F D T+EEFR N+ + + + + D DWR++G VT
Sbjct: 69 KNNFTMKMNKFGDQTSEEFRKSI--DNIPIPAAMTDPHAQNHVSIGLPDYKDWREEGYVT 126
Query: 374 PVKNQYGCNAGWAFAATGSCEGRYAMQTGVLMSFSEEQLIDCSDAYGNSGCKGGSPDNSF 553
PV+NQ C + WAFAA G+ EG+ +TG L S + L+DCS GN GC+ G+ +F
Sbjct: 127 PVRNQGKCGSCWAFAAAGAIEGQMFWKTGNLTPLSVQNLLDCSKTVGNKGCQSGTAHQAF 186
Query: 554 NY-YKPYGMNNEETYPYFGIKDRCKYNNNSVIAHVVSFIDVARNNEIQVAAAVSAEGPLT 730
Y K G+ E TYPY G C+Y + + A++ ++++ NE+ + AV++ GP++
Sbjct: 187 EYVLKNKGLEAEATYPYEGKDGPCRYRSENASANITDYVNLP-PNELYLWVAVASIGPVS 245
Query: 731 A 733
A
Sbjct: 246 A 246
>sp|Q8HY82|CATS_SAIBB Cathepsin S precursor
Length = 330
Score = 170 bits (430), Expect = 4e-42
Identities = 95/247 (38%), Positives = 143/247 (57%), Gaps = 7/247 (2%)
Frame = +2
Query: 8 LFVVSHAT--LHQPTTNAQLNNEWKAFKLLFKKEY-EPIDEVVRRLIWEENLRYIQKHNL 178
LFV S A LH+ T L++ W +K + K+Y E +E VRRLIWE+NL+++ HNL
Sbjct: 8 LFVCSSAVTQLHKDPT---LDHHWNLWKKTYGKQYKEKNEEAVRRLIWEKNLKFVMLHNL 64
Query: 179 EADLGKHTFTLGLNQFADLTNEEFRSKYLSKNLMSRSQINSKFVMPYKTKLND---DEVD 349
E +G H++ LG+N D+T+EE S S + ++ Q N + YK+ N D VD
Sbjct: 65 EHSMGMHSYDLGMNHLGDMTSEEVMSLMSSLRVPNQWQRN----ITYKSNPNQMLPDSVD 120
Query: 350 WRKKGVVTPVKNQYGCNAGWAFAATGSCEGRYAMQTGVLMSFSEEQLIDCSDAYGNSGCK 529
WR+KG VT VK Q C A WAF+A G+ E + ++TG L+S S + L+DCS+ YGN GC
Sbjct: 121 WREKGCVTEVKYQGSCGACWAFSAVGALEAQLKLKTGKLVSLSAQNLVDCSEKYGNKGCN 180
Query: 530 GGSPDNSFNY-YKPYGMNNEETYPYFGIKDRCKYNNNSVIAHVVSFIDVARNNEIQVAAA 706
GG +F Y G+++E +YPY +C+Y++ A + ++ E + A
Sbjct: 181 GGFMTEAFQYIIDNKGIDSEASYPYKATDQKCQYDSKYRAATCSKYTELPYGREDVLKEA 240
Query: 707 VSAEGPL 727
V+ +GP+
Sbjct: 241 VANKGPV 247
Database: Non-redundant SwissProt sequences
Posted date: Dec 6, 2005 7:40 AM
Number of letters in database: 68,354,980
Number of sequences in database: 184,735
Database: swissprot.01
Posted date: Dec 6, 2005 8:18 AM
Number of letters in database: 66,202,850
Number of sequences in database: 184,431
Lambda K H
0.318 0.134 0.401
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 81,311,457
Number of Sequences: 369166
Number of extensions: 1649150
Number of successful extensions: 4760
Number of sequences better than 10.0: 10
Number of HSP's better than 10.0 without gapping: 4346
Number of HSP's successfully gapped in prelim test: 0
Number of HSP's that attempted gapping in prelim test: 0
Number of HSP's gapped (non-prelim): 4476
length of database: 68,354,980
effective HSP length: 108
effective length of database: 48,403,600
effective search space used: 6582889600
frameshift window, decay const: 40, 0.1
T: 12
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)