Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= Dr_sW_007_L08
(810 letters)
Database: Non-redundant SwissProt sequences
184,735 sequences; 68,354,980 total letters
Score E
Sequences producing significant alignments: (bits) Value
sp|Q06561|UNC52_CAEEL Basement membrane proteoglycan precur... 57 8e-08
sp|P98163|YL_DROME Putative vitellogenin receptor precursor... 51 4e-06
sp|Q9NZR2|LRP1B_HUMAN Low-density lipoprotein receptor-rela... 50 1e-05
sp|P98156|VLDLR_MOUSE Very low-density lipoprotein receptor... 49 1e-05
sp|P98155|VLDLR_HUMAN Very low-density lipoprotein receptor... 49 1e-05
sp|P98158|LRP2_RAT Low-density lipoprotein receptor-related... 49 1e-05
sp|Q92673|SORL_HUMAN Sortilin-related receptor precursor (S... 49 1e-05
sp|Q04833|LRP_CAEEL Low-density lipoprotein receptor-relate... 49 2e-05
sp|Q9JI18|LRP1B_MOUSE Low-density lipoprotein receptor-rela... 49 2e-05
sp|Q07954|LRP1_HUMAN Low-density lipoprotein receptor-relat... 49 2e-05
>sp|Q06561|UNC52_CAEEL Basement membrane proteoglycan precursor (Perlecan homolog)
(Uncoordinated protein 52)
Length = 3375
Score = 56.6 bits (135), Expect = 8e-08
Identities = 48/190 (25%), Positives = 69/190 (36%), Gaps = 10/190 (5%)
Frame = +2
Query: 161 TYICTEPDTRDTARSILNVISDLRIVVTPPIIKLRAGQTATFQCYVLNGGRSADHPDFFM 340
TY + D DT SD++I V P ++R G+ +F+C S +
Sbjct: 31 TYQDIDSDDDDT--------SDVQITVFPSEKEVRDGRDVSFECRARTSDNSVYPTVRWA 82
Query: 341 ANGGRASDSQRTTVEKLEAGKVQLT----------YRAVTTNDNGTRFTCRKGRSSADVI 490
GG S + +L VQL+ Y T T G
Sbjct: 83 RVGGPLPSSAHDSGGRLTINPVQLSDAGTYICVSDYNGNTVEARATLSVVSYGPQEVSNG 142
Query: 491 VLVDPICTAGSRLCRNGECINSAKFCDGKRDCADGSDEDQEFCRLCDPLSKRCETHNGQN 670
+ C A + C N EC+ + CDG+ DC D SDE C +S+ CE + +
Sbjct: 143 LRQAGQCMADEKACGNNECVKNDYVCDGEPDCRDRSDEAN-----CPAISRTCEPNEFKC 197
Query: 671 PTNNIYQAHW 700
N Q W
Sbjct: 198 NNNKCVQKMW 207
Score = 42.0 bits (97), Expect = 0.002
Identities = 58/221 (26%), Positives = 83/221 (37%), Gaps = 26/221 (11%)
Frame = +2
Query: 20 RDVVWTFMSKETGQITPLESRWSRSDDPTA----DETSFIILQQAELSDAGTYICTEPDT 187
RDV + ++ + RW+R P D + + +LSDAGTYIC
Sbjct: 60 RDVSFECRARTSDNSVYPTVRWARVGGPLPSSAHDSGGRLTINPVQLSDAGTYICVSDYN 119
Query: 188 RDT--ARSILNVISDLRIVVTPPIIKLRAGQT-------ATFQC----YVLNGGRSADHP 328
+T AR+ L+V+S V+ + +AGQ +C YV +G P
Sbjct: 120 GNTVEARATLSVVSYGPQEVSNGL--RQAGQCMADEKACGNNECVKNDYVCDG-----EP 172
Query: 329 DFFMANGGRASDSQRTTVEKLE--------AGKVQLTYRAVTTNDNGTRFTCRKGRSSAD 484
D + + T E E K+ L DN C SS+D
Sbjct: 173 DCRDRSDEANCPAISRTCEPNEFKCNNNKCVQKMWLCDGDDDCGDNSDELNCNAKPSSSD 232
Query: 485 VIVLVDPICTAGSRLCRNG-ECINSAKFCDGKRDCADGSDE 604
C C + +C+ S+ CDG DC DGSDE
Sbjct: 233 --------CKPTEFQCHDRRQCVPSSFHCDGTNDCHDGSDE 265
Score = 37.4 bits (85), Expect = 0.049
Identities = 30/98 (30%), Positives = 45/98 (45%), Gaps = 17/98 (17%)
Frame = +2
Query: 107 ADETSFII-LQQAELSDAGTYICT--EPDTRDTARS------ILNVISDLRI-------- 235
ADE + ++ +Q+AEL+D G YICT +PDT S + N + ++
Sbjct: 1641 ADENNGLLAVQRAELTDEGDYICTARDPDTGAPIDSTPATVHVTNAAAPPQVEARPPQHP 1700
Query: 236 VVTPPIIKLRAGQTATFQCYVLNGGRSADHPDFFMANG 349
V+TP + G A QC V +A H F +G
Sbjct: 1701 VITPQTQTIPEGDPARIQCTVPGNPSAAQHLSFERVDG 1738
Score = 37.0 bits (84), Expect = 0.064
Identities = 24/84 (28%), Positives = 41/84 (48%), Gaps = 11/84 (13%)
Frame = +2
Query: 80 RWSRSD-----DPTADETSFIILQQAELSDAGTYIC--TEPD----TRDTARSILNVISD 226
+WSR D + + F+ + +++L DAG Y C TEPD AR +N
Sbjct: 1446 KWSRKDGRPLPNGILERDGFLRIDKSQLHDAGEYECTSTEPDGSTQLSPPARLNVNQPQA 1505
Query: 227 LRIVVTPPIIKLRAGQTATFQCYV 298
++ V PP+ + G+ + +C+V
Sbjct: 1506 IQPQVDPPVQTVNEGEPSRIRCWV 1529
Score = 36.2 bits (82), Expect = 0.11
Identities = 21/70 (30%), Positives = 34/70 (48%), Gaps = 7/70 (10%)
Frame = +2
Query: 104 TADETSFIILQQAELSDAGTYICT-EPDTRDTAR---SILNVISD---LRIVVTPPIIKL 262
++D+ + + +L DAG Y+C P+ + S LNV + R V TPP++ +
Sbjct: 1745 SSDDRGVLTIPSTQLQDAGEYVCLYSPENSPPVKTNPSTLNVTPEGTPPRPVATPPLLSV 1804
Query: 263 RAGQTATFQC 292
G A F C
Sbjct: 1805 APGSPARFNC 1814
Score = 35.4 bits (80), Expect = 0.19
Identities = 14/34 (41%), Positives = 20/34 (58%), Gaps = 2/34 (5%)
Frame = +3
Query: 705 CDGEDDCGNGFDESRCSG--NVRECGGLTYQCSD 800
CDG+DDCG+ DE C+ + +C +QC D
Sbjct: 209 CDGDDDCGDNSDELNCNAKPSSSDCKPTEFQCHD 242
Score = 33.5 bits (75), Expect = 0.71
Identities = 13/38 (34%), Positives = 21/38 (55%)
Frame = +3
Query: 687 IKHTGACDGEDDCGNGFDESRCSGNVRECGGLTYQCSD 800
+K+ CDGE DC + DE+ C R C ++C++
Sbjct: 162 VKNDYVCDGEPDCRDRSDEANCPAISRTCEPNEFKCNN 199
Score = 32.3 bits (72), Expect = 1.6
Identities = 30/107 (28%), Positives = 47/107 (43%), Gaps = 8/107 (7%)
Frame = +2
Query: 2 GYRTKNRDVVWTFMSKETGQITPLESRWSRSDDPTADE-TSFIILQQAELSDAGTYICTE 178
GY T+ V WT + G++ S P A +++L+ E +AG Y CT
Sbjct: 1156 GYTTEKIHVEWT----KVGEM---------SLPPNAKAYDGYLVLKGVEAENAGQYRCTA 1202
Query: 179 PD-----TRDTARSILNVISDL--RIVVTPPIIKLRAGQTATFQCYV 298
T D +I IS + V+ PP + + G+ A F+C+V
Sbjct: 1203 TTITQYATDDALLTISKRISGRPPQPVIDPPHLVVNEGEPAAFRCWV 1249
Score = 30.8 bits (68), Expect = 4.6
Identities = 18/60 (30%), Positives = 31/60 (51%), Gaps = 4/60 (6%)
Frame = +2
Query: 131 LQQAELSDAGTYICTEPDTRDTARSILNVISDLRIVVTPPIIKLR----AGQTATFQCYV 298
+ Q++L AG YIC+ + T +S V+ + V+ P + +R Q A F+C+V
Sbjct: 1281 IPQSQLHHAGRYICSAANQYGTGQSPPAVLEVKKPVIPPKVDPIRQTVDRDQPARFKCWV 1340
>sp|P98163|YL_DROME Putative vitellogenin receptor precursor (Yolkless protein) (YL)
Length = 1984
Score = 50.8 bits (120), Expect = 4e-06
Identities = 26/56 (46%), Positives = 30/56 (53%)
Frame = +2
Query: 467 GRSSADVIVLVDPICTAGSRLCRNGECINSAKFCDGKRDCADGSDEDQEFCRLCDP 634
G ++A D C AG CR+G CI AK CDG+ DC D SDE RLC P
Sbjct: 76 GGTAAGTPGSADTRCDAGQFQCRDGGCILQAKMCDGRGDCKDSSDELDCDYRLCRP 131
Score = 46.2 bits (108), Expect = 1e-04
Identities = 24/62 (38%), Positives = 34/62 (54%), Gaps = 1/62 (1%)
Frame = +2
Query: 467 GRSSADVIVLVDPICTAGSRLCRNGECINSAKFCDGKRDCADGSDE-DQEFCRLCDPLSK 643
G +S +++ C G C +G CI + CDG+ DC+DGSDE D+ R C P +
Sbjct: 1144 GDNSDELLCEATSRCEPGMFQCGSGSCIAGSWECDGRIDCSDGSDEHDKCVHRSCPPDMQ 1203
Query: 644 RC 649
RC
Sbjct: 1204 RC 1205
Score = 43.5 bits (101), Expect = 7e-04
Identities = 25/60 (41%), Positives = 31/60 (51%), Gaps = 1/60 (1%)
Frame = +2
Query: 428 TTNDNGTRFTCRKGRSSADVIVLVDPICTAGSRLCRNG-ECINSAKFCDGKRDCADGSDE 604
T NGT C +G AD +C+ CR+G ECI CDG++DC DGSDE
Sbjct: 1261 TVRCNGTT-ECPRGEDEADC----GDVCSIYEFKCRSGRECIRREFRCDGQKDCGDGSDE 1315
Score = 42.7 bits (99), Expect = 0.001
Identities = 23/64 (35%), Positives = 30/64 (46%)
Frame = +2
Query: 509 CTAGSRLCRNGECINSAKFCDGKRDCADGSDEDQEFCRLCDPLSKRCETHNGQNPTNNIY 688
C C NG+C++S+ CDG DC D SDE LC+ S RCE Q + +
Sbjct: 1118 CHVHQHGCDNGKCVDSSLVCDGTNDCGDNSDE-----LLCEATS-RCEPGMFQCGSGSCI 1171
Query: 689 QAHW 700
W
Sbjct: 1172 AGSW 1175
Score = 41.2 bits (95), Expect = 0.003
Identities = 24/65 (36%), Positives = 32/65 (49%), Gaps = 1/65 (1%)
Frame = +2
Query: 458 CRKGRSSADVIVLVDPICTAGSRLCRNGE-CINSAKFCDGKRDCADGSDEDQEFCRLCDP 634
C G + L +P G LCRN E C+ ++ CDG DC+DGSDE D
Sbjct: 253 CGDGSDERGCLNLCEP--QKGKFLCRNRETCLTLSEVCDGHSDCSDGSDETDLCHSKPDC 310
Query: 635 LSKRC 649
+K+C
Sbjct: 311 DAKKC 315
Score = 41.2 bits (95), Expect = 0.003
Identities = 22/53 (41%), Positives = 29/53 (54%), Gaps = 7/53 (13%)
Frame = +2
Query: 530 CRNGECINSAKFCDGKRDCADGSDE---DQEFCR----LCDPLSKRCETHNGQ 667
C +GEC+ C+G+RDC D SDE D+E R LC P C H+G+
Sbjct: 1035 CHSGECLTMNHRCNGRRDCVDNSDEMNCDEEHRRKPKVLCSPNQFAC--HSGE 1085
Score = 40.8 bits (94), Expect = 0.004
Identities = 19/43 (44%), Positives = 24/43 (55%), Gaps = 1/43 (2%)
Frame = +2
Query: 509 CTAGSRLCRNGECINSAKF-CDGKRDCADGSDEDQEFCRLCDP 634
C LC NG C+ ++ CDG DC DGSDE + LC+P
Sbjct: 227 CPGEGHLCANGRCLRRKQWVCDGVDDCGDGSDE-RGCLNLCEP 268
Score = 40.0 bits (92), Expect = 0.008
Identities = 19/52 (36%), Positives = 29/52 (55%), Gaps = 1/52 (1%)
Frame = +2
Query: 506 ICTAGSRLCRNGE-CINSAKFCDGKRDCADGSDEDQEFCRLCDPLSKRCETH 658
+C+ C +GE C++ + CD ++DC D SDE + C D SK+C H
Sbjct: 1073 LCSPNQFACHSGEQCVDKERRCDNRKDCHDHSDE--QHCEKFDK-SKKCHVH 1121
Score = 36.2 bits (82), Expect = 0.11
Identities = 18/52 (34%), Positives = 23/52 (44%)
Frame = +2
Query: 449 RFTCRKGRSSADVIVLVDPICTAGSRLCRNGECINSAKFCDGKRDCADGSDE 604
R C G D V C + C G+C++ + CDG DC D SDE
Sbjct: 1180 RIDCSDGSDEHDKCV--HRSCPPDMQRCLLGQCLDRSLVCDGHNDCGDKSDE 1229
Score = 35.0 bits (79), Expect = 0.24
Identities = 13/39 (33%), Positives = 22/39 (56%)
Frame = +2
Query: 530 CRNGECINSAKFCDGKRDCADGSDEDQEFCRLCDPLSKR 646
C++GEC++ ++ C+ DC +G DE + C S R
Sbjct: 1347 CQDGECVDLSRVCNNFPDCTNGHDEGPKCATACRSASGR 1385
Score = 32.3 bits (72), Expect = 1.6
Identities = 14/34 (41%), Positives = 18/34 (52%)
Frame = +3
Query: 705 CDGEDDCGNGFDESRCSGNVRECGGLTYQCSDGT 806
CDG +DCG+ DE C R C +QC G+
Sbjct: 1137 CDGTNDCGDNSDELLCEATSR-CEPGMFQCGSGS 1169
Score = 32.0 bits (71), Expect = 2.1
Identities = 17/54 (31%), Positives = 22/54 (40%), Gaps = 15/54 (27%)
Frame = +3
Query: 687 IKHTGACDGEDDCGNGFDESRC---------------SGNVRECGGLTYQCSDG 803
I+ CDG+ DCG+G DE C S + R C + C DG
Sbjct: 1297 IRREFRCDGQKDCGDGSDELSCELEKGHHNQSQIQPWSTSSRSCRPHLFDCQDG 1350
Score = 30.8 bits (68), Expect = 4.6
Identities = 11/16 (68%), Positives = 12/16 (75%)
Frame = +3
Query: 705 CDGEDDCGNGFDESRC 752
CDG DDCG+G DE C
Sbjct: 247 CDGVDDCGDGSDERGC 262
Score = 30.4 bits (67), Expect = 6.0
Identities = 14/39 (35%), Positives = 18/39 (46%), Gaps = 4/39 (10%)
Frame = +3
Query: 705 CDGEDDCGNGFDESRCSGNVR----ECGGLTYQCSDGTK 809
CDG +DCG+ DE C + C YQC+ K
Sbjct: 1217 CDGHNDCGDKSDELNCGTDSSTMNISCAEDQYQCTSNLK 1255
>sp|Q9NZR2|LRP1B_HUMAN Low-density lipoprotein receptor-related protein 1B precursor
(Low-density lipoprotein receptor-related protein-deleted
in tumor) (LRP-DIT)
Length = 4599
Score = 49.7 bits (117), Expect = 1e-05
Identities = 26/61 (42%), Positives = 32/61 (52%), Gaps = 11/61 (18%)
Frame = +2
Query: 509 CTAGSRLCRNGECINSAKFCDGKRDCADGSDE---------DQEFCR--LCDPLSKRCET 655
CT LC NG+C++S +CDG DCADGSDE DQ C C P +C+
Sbjct: 3515 CTLKDFLCANGDCVSSRFWCDGDFDCADGSDERNCETSCSKDQFRCSNGQCIPAKWKCDG 3574
Query: 656 H 658
H
Sbjct: 3575 H 3575
Score = 48.5 bits (114), Expect = 2e-05
Identities = 25/62 (40%), Positives = 31/62 (50%)
Frame = +2
Query: 434 NDNGTRFTCRKGRSSADVIVLVDPICTAGSRLCRNGECINSAKFCDGKRDCADGSDEDQE 613
++NGT T G + + IC AG C+N CI + CDG DC DGSDED
Sbjct: 827 DENGTTCTFNPGEA-------LPHICKAGEFRCKNRHCIQARWKCDGDDDCLDGSDEDSV 879
Query: 614 FC 619
C
Sbjct: 880 NC 881
Score = 47.0 bits (110), Expect = 6e-05
Identities = 21/46 (45%), Positives = 27/46 (58%)
Frame = +2
Query: 509 CTAGSRLCRNGECINSAKFCDGKRDCADGSDEDQEFCRLCDPLSKR 646
C + +C+NG CI S CD K DC DGSDE C + + LSK+
Sbjct: 2891 CNSSFFMCKNGRCIPSGGLCDNKDDCGDGSDERN--CHINECLSKK 2934
Score = 43.9 bits (102), Expect = 5e-04
Identities = 21/62 (33%), Positives = 28/62 (45%)
Frame = +2
Query: 464 KGRSSADVIVLVDPICTAGSRLCRNGECINSAKFCDGKRDCADGSDEDQEFCRLCDPLSK 643
K +S ++ + C G + C N CI K CDG+ DC D SDE C +
Sbjct: 2537 KDKSDEKLLYCENRSCRRGFKPCYNRRCIPHGKLCDGENDCGDNSDELDCKVSTCATVEF 2596
Query: 644 RC 649
RC
Sbjct: 2597 RC 2598
Score = 41.6 bits (96), Expect = 0.003
Identities = 18/40 (45%), Positives = 24/40 (60%)
Frame = +3
Query: 687 IKHTGACDGEDDCGNGFDESRCSGNVRECGGLTYQCSDGT 806
I H CDGE+DCG+ DE C V C + ++C+DGT
Sbjct: 2565 IPHGKLCDGENDCGDNSDELDC--KVSTCATVEFRCADGT 2602
Score = 40.8 bits (94), Expect = 0.004
Identities = 23/56 (41%), Positives = 24/56 (42%), Gaps = 9/56 (16%)
Frame = +2
Query: 509 CTAGSRLCRN---------GECINSAKFCDGKRDCADGSDEDQEFCRLCDPLSKRC 649
C RLC + G CIN A CDG DC D SDED LC P C
Sbjct: 1088 CNGTIRLCDHKTKFSCWSTGRCINKAWVCDGDIDCEDQSDEDDCDSFLCGPPKHPC 1143
Score = 40.4 bits (93), Expect = 0.006
Identities = 15/34 (44%), Positives = 24/34 (70%)
Frame = +2
Query: 503 PICTAGSRLCRNGECINSAKFCDGKRDCADGSDE 604
P C++ +C + CI+++ C+G+ DCADGSDE
Sbjct: 3592 PTCSSREYICASDGCISASLKCNGEYDCADGSDE 3625
Score = 39.7 bits (91), Expect = 0.010
Identities = 18/49 (36%), Positives = 24/49 (48%)
Frame = +2
Query: 509 CTAGSRLCRNGECINSAKFCDGKRDCADGSDEDQEFCRLCDPLSKRCET 655
C+ C NG+CI + CDG DC G DE + C+P S C +
Sbjct: 3553 CSKDQFRCSNGQCIPAKWKCDGHEDCKYGEDE-----KSCEPASPTCSS 3596
Score = 39.3 bits (90), Expect = 0.013
Identities = 17/33 (51%), Positives = 22/33 (66%)
Frame = +3
Query: 705 CDGEDDCGNGFDESRCSGNVRECGGLTYQCSDG 803
CD +DDCG+G DES G R+CG + C+DG
Sbjct: 2824 CDHDDDCGDGSDESPQCG-YRQCGTEEFSCADG 2855
Score = 38.5 bits (88), Expect = 0.022
Identities = 21/55 (38%), Positives = 26/55 (47%), Gaps = 2/55 (3%)
Frame = +2
Query: 506 ICTAGSRLCRNGE--CINSAKFCDGKRDCADGSDEDQEFCRLCDPLSKRCETHNG 664
+C C N C+ K C+GK+DC DGSDE LCD C +NG
Sbjct: 1135 LCGPPKHPCANDTSVCLQPEKLCNGKKDCPDGSDEGY----LCD----ECSLNNG 1181
Score = 38.5 bits (88), Expect = 0.022
Identities = 24/67 (35%), Positives = 29/67 (43%), Gaps = 13/67 (19%)
Frame = +2
Query: 509 CTAGSRLCRNGECINSAKFCDGKRDCADGSDE---DQEFC----------RLCDPLSKRC 649
C G C G C A CDG+ DC D SDE D C + C P++ RC
Sbjct: 3357 CQPGRFQCGTGLCALPAFICDGENDCGDNSDELNCDTHVCLSGQFKCTKNQKCIPVNLRC 3416
Query: 650 ETHNGQN 670
NGQ+
Sbjct: 3417 ---NGQD 3420
Score = 38.5 bits (88), Expect = 0.022
Identities = 17/38 (44%), Positives = 19/38 (50%)
Frame = +2
Query: 506 ICTAGSRLCRNGECINSAKFCDGKRDCADGSDEDQEFC 619
IC A LC N C CDG+ DC D SDE + C
Sbjct: 3673 ICRADEFLCNNSLCKLHFWVCDGEDDCGDNSDEAPDMC 3710
Score = 38.1 bits (87), Expect = 0.029
Identities = 24/66 (36%), Positives = 27/66 (40%), Gaps = 15/66 (22%)
Frame = +2
Query: 509 CTAGSRL-CRNGECINSAKFCDGKRDCADGSDEDQEFC--------------RLCDPLSK 643
C A S C NGECI+ CDG C D SDE +C R C P K
Sbjct: 2510 CNAYSEFECGNGECIDYQLTCDGIPHCKDKSDEKLLYCENRSCRRGFKPCYNRRCIPHGK 2569
Query: 644 RCETHN 661
C+ N
Sbjct: 2570 LCDGEN 2575
Score = 37.7 bits (86), Expect = 0.037
Identities = 14/26 (53%), Positives = 18/26 (69%)
Frame = +2
Query: 527 LCRNGECINSAKFCDGKRDCADGSDE 604
+C++G CI+S CD DC DGSDE
Sbjct: 974 VCKSGRCISSKWHCDSDDDCGDGSDE 999
Score = 37.4 bits (85), Expect = 0.049
Identities = 28/99 (28%), Positives = 36/99 (36%), Gaps = 15/99 (15%)
Frame = +2
Query: 446 TRFTCRKGR---------------SSADVIVLVDPICTAGSRLCRNGECINSAKFCDGKR 580
T+F C+ GR +D + V C C +G CI CDG
Sbjct: 971 TQFVCKSGRCISSKWHCDSDDDCGDGSDEVGCVHS-CFDNQFRCSSGRCIPGHWACDGDN 1029
Query: 581 DCADGSDEDQEFCRLCDPLSKRCETHNGQNPTNNIYQAH 697
DC D SDE Q C + E H+ N +Q H
Sbjct: 1030 DCGDFSDEAQINC-------TKEEIHSPAGCNGNEFQCH 1061
Score = 37.4 bits (85), Expect = 0.049
Identities = 15/40 (37%), Positives = 19/40 (47%)
Frame = +2
Query: 500 DPICTAGSRLCRNGECINSAKFCDGKRDCADGSDEDQEFC 619
D C+ C +CI+ CDG+ DC DG DE C
Sbjct: 2717 DSSCSWNQFACSAQKCISKHWICDGEDDCGDGLDESDSIC 2756
Score = 37.4 bits (85), Expect = 0.049
Identities = 21/52 (40%), Positives = 22/52 (42%)
Frame = +2
Query: 545 CINSAKFCDGKRDCADGSDEDQEFCRLCDPLSKRCETHNGQNPTNNIYQAHW 700
CI+ CD DCAD SDE CD K C H Q NN HW
Sbjct: 3449 CISKLWVCDEDPDCADASDEAN-----CD--KKTCGPHEFQCKNNNCIPDHW 3493
Score = 36.6 bits (83), Expect = 0.083
Identities = 19/48 (39%), Positives = 24/48 (50%), Gaps = 3/48 (6%)
Frame = +2
Query: 509 CTAGSRLCR-NGECINSAKFCDGKRDCADGSDED--QEFCRLCDPLSK 643
C C +G C+ CDG++DC DGSDE RLCD +K
Sbjct: 1053 CNGNEFQCHPDGNCVPDLWRCDGEKDCEDGSDEKGCNGTIRLCDHKTK 1100
Score = 36.2 bits (82), Expect = 0.11
Identities = 13/23 (56%), Positives = 16/23 (69%)
Frame = +3
Query: 705 CDGEDDCGNGFDESRCSGNVREC 773
CDGE DC +G DE C+G +R C
Sbjct: 1073 CDGEKDCEDGSDEKGCNGTIRLC 1095
Score = 36.2 bits (82), Expect = 0.11
Identities = 13/25 (52%), Positives = 17/25 (68%)
Frame = +2
Query: 530 CRNGECINSAKFCDGKRDCADGSDE 604
C +G CI + CDG++DC DG DE
Sbjct: 2689 CPSGRCILNTWICDGQKDCEDGRDE 2713
Score = 35.8 bits (81), Expect = 0.14
Identities = 15/39 (38%), Positives = 21/39 (53%), Gaps = 1/39 (2%)
Frame = +2
Query: 506 ICTAGSRLCRNG-ECINSAKFCDGKRDCADGSDEDQEFC 619
+C G LC + C++ + CDG DC D SDE + C
Sbjct: 31 LCDPGEFLCHDHVTCVSQSWLCDGDPDCPDDSDESLDTC 69
Score = 35.8 bits (81), Expect = 0.14
Identities = 16/39 (41%), Positives = 21/39 (53%), Gaps = 5/39 (12%)
Frame = +3
Query: 699 GACDGEDDCGNGFDESRCSGNVREC-----GGLTYQCSD 800
G CD +DDCG+G DE C ++ EC G + C D
Sbjct: 2908 GLCDNKDDCGDGSDERNC--HINECLSKKVSGCSQDCQD 2944
Score = 35.4 bits (80), Expect = 0.19
Identities = 15/49 (30%), Positives = 19/49 (38%)
Frame = +2
Query: 473 SSADVIVLVDPICTAGSRLCRNGECINSAKFCDGKRDCADGSDEDQEFC 619
S D + + C C+N CI CDG DC DE + C
Sbjct: 874 SDEDSVNCFNHSCPDDQFKCQNNRCIPKRWLCDGANDCGSNEDESNQTC 922
Score = 35.4 bits (80), Expect = 0.19
Identities = 18/47 (38%), Positives = 23/47 (48%), Gaps = 2/47 (4%)
Frame = +2
Query: 509 CTAGSRLCRNGECINSAKFCDGKRDCADGSDEDQEFCRL--CDPLSK 643
C C NG CI A CD + DC D +DE C C+PL++
Sbjct: 927 CQVDQFSCGNGRCIPRAWLCDREDDCGDQTDE-MASCEFPTCEPLTQ 972
Score = 35.4 bits (80), Expect = 0.19
Identities = 19/50 (38%), Positives = 23/50 (46%), Gaps = 1/50 (2%)
Frame = +2
Query: 509 CTAGSRLCRNGECINSAKFCDGKRDCADGSDEDQEFCRL-CDPLSKRCET 655
CTA C+ +CI CD DC DGSDE + C P +C T
Sbjct: 3317 CTASQFRCKTDKCIPFWWKCDTVDDCGDGSDEPDDCPEFRCQPGRFQCGT 3366
Score = 35.0 bits (79), Expect = 0.24
Identities = 15/33 (45%), Positives = 19/33 (57%)
Frame = +3
Query: 705 CDGEDDCGNGFDESRCSGNVRECGGLTYQCSDG 803
CD +DDCG+G DE C V C ++CS G
Sbjct: 987 CDSDDDCGDGSDEVGC---VHSCFDNQFRCSSG 1016
Score = 35.0 bits (79), Expect = 0.24
Identities = 14/30 (46%), Positives = 16/30 (53%)
Frame = +3
Query: 705 CDGEDDCGNGFDESRCSGNVRECGGLTYQC 794
CDGEDDCG+G DES C + C
Sbjct: 2739 CDGEDDCGDGLDESDSICGAITCAADMFSC 2768
Score = 34.3 bits (77), Expect = 0.41
Identities = 14/35 (40%), Positives = 17/35 (48%)
Frame = +2
Query: 509 CTAGSRLCRNGECINSAKFCDGKRDCADGSDEDQE 613
C + +C N CI CD DC DGSDE +
Sbjct: 2805 CDENAFMCHNKVCIPKQFVCDHDDDCGDGSDESPQ 2839
Score = 33.9 bits (76), Expect = 0.54
Identities = 15/33 (45%), Positives = 18/33 (54%), Gaps = 1/33 (3%)
Frame = +2
Query: 509 CTAGSRLCRNGE-CINSAKFCDGKRDCADGSDE 604
C A C+ C+ CDG+RDC DGSDE
Sbjct: 2761 CAADMFSCQGSRACVPRHWLCDGERDCPDGSDE 2793
Score = 33.9 bits (76), Expect = 0.54
Identities = 15/37 (40%), Positives = 20/37 (54%), Gaps = 3/37 (8%)
Frame = +2
Query: 530 CRNGECINSAKFCDGKRDCADGSDEDQ---EFCRLCD 631
C+N CI CD + DC+D SDE+ + C L D
Sbjct: 3483 CKNNNCIPDHWRCDSQNDCSDNSDEENCKPQTCTLKD 3519
Score = 33.9 bits (76), Expect = 0.54
Identities = 18/53 (33%), Positives = 22/53 (41%), Gaps = 1/53 (1%)
Frame = +2
Query: 452 FTCRKGRSSADVIVLVDPICTAGSRLCRN-GECINSAKFCDGKRDCADGSDED 607
+ C G D + C C+N CI CDG DC DGSDE+
Sbjct: 3617 YDCADGSDEMDCVTE----CKEDQFRCKNKAHCIPIRWLCDGIHDCVDGSDEE 3665
Score = 33.9 bits (76), Expect = 0.54
Identities = 19/48 (39%), Positives = 22/48 (45%)
Frame = +2
Query: 509 CTAGSRLCRNGECINSAKFCDGKRDCADGSDEDQEFCRLCDPLSKRCE 652
C C N +CI CD DC DGSDE + CR+ P CE
Sbjct: 3762 CKKDEFACSNKKCIPMDLQCDRLDDCGDGSDE--QGCRIA-PTEYTCE 3806
Score = 32.3 bits (72), Expect = 1.6
Identities = 13/33 (39%), Positives = 18/33 (54%)
Frame = +3
Query: 705 CDGEDDCGNGFDESRCSGNVRECGGLTYQCSDG 803
CDG +DCG+ DES + R C + C +G
Sbjct: 905 CDGANDCGSNEDESNQTCTARTCQVDQFSCGNG 937
Score = 32.3 bits (72), Expect = 1.6
Identities = 14/35 (40%), Positives = 20/35 (57%)
Frame = +3
Query: 705 CDGEDDCGNGFDESRCSGNVRECGGLTYQCSDGTK 809
CDGE+DCG+ DE C +V C ++C+ K
Sbjct: 3376 CDGENDCGDNSDELNCDTHV--CLSGQFKCTKNQK 3408
Score = 32.3 bits (72), Expect = 1.6
Identities = 13/27 (48%), Positives = 17/27 (62%), Gaps = 1/27 (3%)
Frame = +2
Query: 530 CRNGE-CINSAKFCDGKRDCADGSDED 607
CRN C+ S + C+G +C D SDED
Sbjct: 3723 CRNNRICLQSEQMCNGIDECGDNSDED 3749
Score = 32.0 bits (71), Expect = 2.1
Identities = 17/51 (33%), Positives = 25/51 (49%), Gaps = 1/51 (1%)
Frame = +2
Query: 506 ICTAGSRLC-RNGECINSAKFCDGKRDCADGSDEDQEFCRLCDPLSKRCET 655
+C +G C +N +CI C+G+ DC D DE C P +C+T
Sbjct: 3395 VCLSGQFKCTKNQKCIPVNLRCNGQDDCGDEEDERDCPENSCSPDYFQCKT 3445
Score = 31.6 bits (70), Expect = 2.7
Identities = 13/33 (39%), Positives = 18/33 (54%)
Frame = +3
Query: 705 CDGEDDCGNGFDESRCSGNVRECGGLTYQCSDG 803
CDG+ DC +G DE C C ++CS+G
Sbjct: 3534 CDGDFDCADGSDERNCE---TSCSKDQFRCSNG 3563
Score = 31.6 bits (70), Expect = 2.7
Identities = 15/34 (44%), Positives = 16/34 (47%), Gaps = 1/34 (2%)
Frame = +3
Query: 705 CDGEDDCGNGFDESRCSGNVRECGGLTYQC-SDG 803
CDG +DC G DE C C Y C SDG
Sbjct: 3572 CDGHEDCKYGEDEKSCEPASPTCSSREYICASDG 3605
Score = 31.2 bits (69), Expect = 3.5
Identities = 14/37 (37%), Positives = 21/37 (56%), Gaps = 6/37 (16%)
Frame = +3
Query: 702 ACDGEDDCGNGFDESRCSGNVRE------CGGLTYQC 794
ACDG++DCG+ DE++ + E C G +QC
Sbjct: 1024 ACDGDNDCGDFSDEAQINCTKEEIHSPAGCNGNEFQC 1060
Score = 30.8 bits (68), Expect = 4.6
Identities = 14/42 (33%), Positives = 21/42 (50%)
Frame = +2
Query: 542 ECINSAKFCDGKRDCADGSDEDQEFCRLCDPLSKRCETHNGQ 667
+C++ ++ C+G DC DG DE C L C+ N Q
Sbjct: 89 KCVHLSQLCNGVLDCPDGYDEGVH----CQELLSNCQQLNCQ 126
Score = 30.8 bits (68), Expect = 4.6
Identities = 14/37 (37%), Positives = 19/37 (51%), Gaps = 1/37 (2%)
Frame = +3
Query: 696 TGACDGEDDCGNGFDESRCS-GNVRECGGLTYQCSDG 803
T CDG +DCG+ DE +C N +C + C G
Sbjct: 2656 TWICDGSNDCGDYSDELKCPVQNKHKCEENYFSCPSG 2692
Score = 30.8 bits (68), Expect = 4.6
Identities = 11/18 (61%), Positives = 13/18 (72%)
Frame = +3
Query: 693 HTGACDGEDDCGNGFDES 746
H CDGEDDCG+ DE+
Sbjct: 3689 HFWVCDGEDDCGDNSDEA 3706
Score = 30.4 bits (67), Expect = 6.0
Identities = 13/32 (40%), Positives = 16/32 (50%)
Frame = +2
Query: 509 CTAGSRLCRNGECINSAKFCDGKRDCADGSDE 604
C C +G CI + C+ DCAD SDE
Sbjct: 2591 CATVEFRCADGTCIPRSARCNQNIDCADASDE 2622
Score = 30.4 bits (67), Expect = 6.0
Identities = 14/37 (37%), Positives = 19/37 (51%)
Frame = +3
Query: 687 IKHTGACDGEDDCGNGFDESRCSGNVRECGGLTYQCS 797
I +T CDG+ DC +G DE C + C + CS
Sbjct: 2695 ILNTWICDGQKDCEDGRDEFHCDSS---CSWNQFACS 2728
Score = 30.4 bits (67), Expect = 6.0
Identities = 15/43 (34%), Positives = 24/43 (55%), Gaps = 1/43 (2%)
Frame = +2
Query: 530 CRNGECINSAKF-CDGKRDCADGSDEDQEFCRLCDPLSKRCET 655
C +G C+ + ++ CDG DC D SDE PL+ +C++
Sbjct: 2852 CADGRCLLNTQWQCDGDFDCPDHSDE--------APLNPKCKS 2886
Score = 30.4 bits (67), Expect = 6.0
Identities = 13/36 (36%), Positives = 19/36 (52%), Gaps = 4/36 (11%)
Frame = +3
Query: 705 CDGEDDCGNGFDESRCSGNV----RECGGLTYQCSD 800
C+G D+CG+ DE C G + R C + CS+
Sbjct: 3736 CNGIDECGDNSDEDHCGGKLTYKARPCKKDEFACSN 3771
Score = 30.0 bits (66), Expect = 7.8
Identities = 13/30 (43%), Positives = 17/30 (56%)
Frame = +3
Query: 705 CDGEDDCGNGFDESRCSGNVRECGGLTYQC 794
C+G+DDCG+ DE C N C +QC
Sbjct: 3416 CNGQDDCGDEEDERDCPEN--SCSPDYFQC 3443
Score = 30.0 bits (66), Expect = 7.8
Identities = 15/37 (40%), Positives = 16/37 (43%), Gaps = 9/37 (24%)
Frame = +3
Query: 705 CDGEDDCGNGFDES---------RCSGNVRECGGLTY 788
CD DDCG+G DE C NV CG Y
Sbjct: 3781 CDRLDDCGDGSDEQGCRIAPTEYTCEDNVNPCGDDAY 3817
>sp|P98156|VLDLR_MOUSE Very low-density lipoprotein receptor precursor (VLDL receptor)
Length = 873
Score = 49.3 bits (116), Expect = 1e-05
Identities = 26/78 (33%), Positives = 36/78 (46%), Gaps = 16/78 (20%)
Frame = +2
Query: 497 VDPICTAGSRLCRNGECINSAKFCDGKRDCADGSDEDQEFCRL----------------C 628
V C +C+NG+C+ + CDG DC DGSDE E C + C
Sbjct: 68 VKKTCAESDFVCKNGQCVPNRWQCDGDPDCEDGSDESPEQCHMRTCRINEISCGARSTQC 127
Query: 629 DPLSKRCETHNGQNPTNN 682
P+S RC+ G+N +N
Sbjct: 128 IPVSWRCD---GENDCDN 142
Score = 43.9 bits (102), Expect = 5e-04
Identities = 20/49 (40%), Positives = 28/49 (57%)
Frame = +2
Query: 518 GSRLCRNGECINSAKFCDGKRDCADGSDEDQEFCRLCDPLSKRCETHNG 664
G CR+GECI+ +K CD ++DC D SDE + C + C +NG
Sbjct: 322 GKFKCRSGECIDMSKVCDQEQDCRDWSDEPLKECHI-----NECLVNNG 365
Score = 43.5 bits (101), Expect = 7e-04
Identities = 21/48 (43%), Positives = 23/48 (47%)
Frame = +2
Query: 509 CTAGSRLCRNGECINSAKFCDGKRDCADGSDEDQEFCRLCDPLSKRCE 652
C C +GECI+ CDG DC DGSDE R C P CE
Sbjct: 239 CPTSEIQCGSGECIHKKWRCDGDPDCKDGSDEVNCPSRTCRPDQFECE 286
Score = 42.4 bits (98), Expect = 0.002
Identities = 22/53 (41%), Positives = 25/53 (47%)
Frame = +2
Query: 509 CTAGSRLCRNGECINSAKFCDGKRDCADGSDEDQEFCRLCDPLSKRCETHNGQ 667
C + C NG CI CDG DCADGSDE + C C+ NGQ
Sbjct: 33 CDSSQFQCTNGRCITLLWKCDGDEDCADGSDEKNCVKKTCAESDFVCK--NGQ 83
Score = 40.8 bits (94), Expect = 0.004
Identities = 26/98 (26%), Positives = 33/98 (33%), Gaps = 15/98 (15%)
Frame = +2
Query: 452 FTCRKGR---------------SSADVIVLVDPICTAGSRLCRNGECINSAKFCDGKRDC 586
FTC GR +D + P C A C CI + CD DC
Sbjct: 159 FTCSSGRCVSRNFVCNGQDDCDDGSDELDCAPPTCGAHEFQCSTSSCIPLSWVCDDDADC 218
Query: 587 ADGSDEDQEFCRLCDPLSKRCETHNGQNPTNNIYQAHW 700
+D SDE E C + +C T Q + W
Sbjct: 219 SDQSDESLEQCGRQPVIHTKCPTSEIQCGSGECIHKKW 256
Score = 39.7 bits (91), Expect = 0.010
Identities = 20/64 (31%), Positives = 28/64 (43%)
Frame = +2
Query: 509 CTAGSRLCRNGECINSAKFCDGKRDCADGSDEDQEFCRLCDPLSKRCETHNGQNPTNNIY 688
C+A C +G C++ C+G+ DC DGSDE D C H Q T++
Sbjct: 154 CSADEFTCSSGRCVSRNFVCNGQDDCDDGSDE-------LDCAPPTCGAHEFQCSTSSCI 206
Query: 689 QAHW 700
W
Sbjct: 207 PLSW 210
Score = 39.7 bits (91), Expect = 0.010
Identities = 16/45 (35%), Positives = 24/45 (53%)
Frame = +2
Query: 470 RSSADVIVLVDPICTAGSRLCRNGECINSAKFCDGKRDCADGSDE 604
+ +D + C C +G CI+ ++ C+G RDC DGSDE
Sbjct: 265 KDGSDEVNCPSRTCRPDQFECEDGSCIHGSRQCNGIRDCVDGSDE 309
Score = 37.4 bits (85), Expect = 0.049
Identities = 17/33 (51%), Positives = 20/33 (60%)
Frame = +3
Query: 705 CDGEDDCGNGFDESRCSGNVRECGGLTYQCSDG 803
CDGE+DC NG DE C GN+ C + CS G
Sbjct: 134 CDGENDCDNGEDEENC-GNI-TCSADEFTCSSG 164
Score = 33.5 bits (75), Expect = 0.71
Identities = 14/31 (45%), Positives = 19/31 (61%)
Frame = +3
Query: 705 CDGEDDCGNGFDESRCSGNVRECGGLTYQCS 797
C+G+DDC +G DE C+ CG +QCS
Sbjct: 173 CNGQDDCDDGSDELDCAPPT--CGAHEFQCS 201
Score = 33.5 bits (75), Expect = 0.71
Identities = 14/34 (41%), Positives = 19/34 (55%)
Frame = +3
Query: 705 CDGEDDCGNGFDESRCSGNVRECGGLTYQCSDGT 806
CDG+ DC +G DE C R C ++C DG+
Sbjct: 258 CDGDPDCKDGSDEVNCPS--RTCRPDQFECEDGS 289
Score = 31.6 bits (70), Expect = 2.7
Identities = 12/33 (36%), Positives = 18/33 (54%)
Frame = +3
Query: 705 CDGEDDCGNGFDESRCSGNVRECGGLTYQCSDG 803
CDG++DC +G DE C + C + C +G
Sbjct: 52 CDGDEDCADGSDEKNCV--KKTCAESDFVCKNG 82
Score = 30.4 bits (67), Expect = 6.0
Identities = 15/37 (40%), Positives = 18/37 (48%), Gaps = 7/37 (18%)
Frame = +3
Query: 705 CDGEDDCGNGFDES-------RCSGNVRECGGLTYQC 794
CDG+ DC +G DES C N CG + QC
Sbjct: 91 CDGDPDCEDGSDESPEQCHMRTCRINEISCGARSTQC 127
>sp|P98155|VLDLR_HUMAN Very low-density lipoprotein receptor precursor (VLDL receptor)
Length = 873
Score = 49.3 bits (116), Expect = 1e-05
Identities = 25/71 (35%), Positives = 31/71 (43%), Gaps = 16/71 (22%)
Frame = +2
Query: 497 VDPICTAGSRLCRNGECINSAKFCDGKRDCADGSDEDQEFCRL----------------C 628
V C +C NG+C+ S CDG DC DGSDE E C + C
Sbjct: 68 VKKTCAESDFVCNNGQCVPSRWKCDGDPDCEDGSDESPEQCHMRTCRIHEISCGAHSTQC 127
Query: 629 DPLSKRCETHN 661
P+S RC+ N
Sbjct: 128 IPVSWRCDGEN 138
Score = 45.1 bits (105), Expect = 2e-04
Identities = 22/48 (45%), Positives = 24/48 (50%)
Frame = +2
Query: 509 CTAGSRLCRNGECINSAKFCDGKRDCADGSDEDQEFCRLCDPLSKRCE 652
C A C +GECI+ CDG DC DGSDE R C P CE
Sbjct: 239 CPASEIQCGSGECIHKKWRCDGDPDCKDGSDEVNCPSRTCRPDQFECE 286
Score = 41.6 bits (96), Expect = 0.003
Identities = 19/49 (38%), Positives = 28/49 (57%)
Frame = +2
Query: 518 GSRLCRNGECINSAKFCDGKRDCADGSDEDQEFCRLCDPLSKRCETHNG 664
G CR+GECI+ +K C+ ++DC D SDE + C + C +NG
Sbjct: 322 GKFKCRSGECIDISKVCNQEQDCRDWSDEPLKECHI-----NECLVNNG 365
Score = 40.0 bits (92), Expect = 0.008
Identities = 21/53 (39%), Positives = 23/53 (43%)
Frame = +2
Query: 509 CTAGSRLCRNGECINSAKFCDGKRDCADGSDEDQEFCRLCDPLSKRCETHNGQ 667
C C NG CI CDG DC DGSDE + C C +NGQ
Sbjct: 33 CEPSQFQCTNGRCITLLWKCDGDEDCVDGSDEKNCVKKTCAESDFVC--NNGQ 83
Score = 39.7 bits (91), Expect = 0.010
Identities = 16/45 (35%), Positives = 24/45 (53%)
Frame = +2
Query: 470 RSSADVIVLVDPICTAGSRLCRNGECINSAKFCDGKRDCADGSDE 604
+ +D + C C +G CI+ ++ C+G RDC DGSDE
Sbjct: 265 KDGSDEVNCPSRTCRPDQFECEDGSCIHGSRQCNGIRDCVDGSDE 309
Score = 39.3 bits (90), Expect = 0.013
Identities = 20/64 (31%), Positives = 28/64 (43%)
Frame = +2
Query: 509 CTAGSRLCRNGECINSAKFCDGKRDCADGSDEDQEFCRLCDPLSKRCETHNGQNPTNNIY 688
C+ C +G CI+ C+G+ DC+DGSDE D C H Q T++
Sbjct: 154 CSPDEFTCSSGRCISRNFVCNGQDDCSDGSDE-------LDCAPPTCGAHEFQCSTSSCI 206
Query: 689 QAHW 700
W
Sbjct: 207 PISW 210
Score = 38.9 bits (89), Expect = 0.017
Identities = 25/98 (25%), Positives = 32/98 (32%), Gaps = 15/98 (15%)
Frame = +2
Query: 452 FTCRKGR---------------SSADVIVLVDPICTAGSRLCRNGECINSAKFCDGKRDC 586
FTC GR +D + P C A C CI + CD DC
Sbjct: 159 FTCSSGRCISRNFVCNGQDDCSDGSDELDCAPPTCGAHEFQCSTSSCIPISWVCDDDADC 218
Query: 587 ADGSDEDQEFCRLCDPLSKRCETHNGQNPTNNIYQAHW 700
+D SDE E C + +C Q + W
Sbjct: 219 SDQSDESLEQCGRQPVIHTKCPASEIQCGSGECIHKKW 256
Score = 34.7 bits (78), Expect = 0.32
Identities = 16/33 (48%), Positives = 20/33 (60%)
Frame = +3
Query: 705 CDGEDDCGNGFDESRCSGNVRECGGLTYQCSDG 803
CDGE+DC +G DE C GN+ C + CS G
Sbjct: 134 CDGENDCDSGEDEENC-GNI-TCSPDEFTCSSG 164
Score = 34.3 bits (77), Expect = 0.41
Identities = 15/37 (40%), Positives = 20/37 (54%)
Frame = +3
Query: 687 IKHTGACDGEDDCGNGFDESRCSGNVRECGGLTYQCS 797
I C+G+DDC +G DE C+ CG +QCS
Sbjct: 167 ISRNFVCNGQDDCSDGSDELDCAPPT--CGAHEFQCS 201
Score = 33.5 bits (75), Expect = 0.71
Identities = 14/34 (41%), Positives = 19/34 (55%)
Frame = +3
Query: 705 CDGEDDCGNGFDESRCSGNVRECGGLTYQCSDGT 806
CDG+ DC +G DE C R C ++C DG+
Sbjct: 258 CDGDPDCKDGSDEVNCPS--RTCRPDQFECEDGS 289
Score = 30.8 bits (68), Expect = 4.6
Identities = 12/33 (36%), Positives = 19/33 (57%)
Frame = +3
Query: 705 CDGEDDCGNGFDESRCSGNVRECGGLTYQCSDG 803
CDG++DC +G DE C + C + C++G
Sbjct: 52 CDGDEDCVDGSDEKNCV--KKTCAESDFVCNNG 82
Score = 30.4 bits (67), Expect = 6.0
Identities = 21/70 (30%), Positives = 27/70 (38%), Gaps = 18/70 (25%)
Frame = +2
Query: 500 DPICTAGS---------RLCR---------NGECINSAKFCDGKRDCADGSDEDQEFCRL 625
DP C GS R CR + +CI + CDG+ DC G DE+
Sbjct: 94 DPDCEDGSDESPEQCHMRTCRIHEISCGAHSTQCIPVSWRCDGENDCDSGEDEENCGNIT 153
Query: 626 CDPLSKRCET 655
C P C +
Sbjct: 154 CSPDEFTCSS 163
>sp|P98158|LRP2_RAT Low-density lipoprotein receptor-related protein 2 precursor
(Megalin) (Glycoprotein 330) (gp330)
Length = 4660
Score = 49.3 bits (116), Expect = 1e-05
Identities = 22/64 (34%), Positives = 30/64 (46%)
Frame = +2
Query: 509 CTAGSRLCRNGECINSAKFCDGKRDCADGSDEDQEFCRLCDPLSKRCETHNGQNPTNNIY 688
C G CR+G C + C+ ++DCADGSDED+ C RCE++ Q
Sbjct: 3555 CRLGQFQCRDGNCTSPQALCNARQDCADGSDEDRVLCE-----HHRCESNEWQCANKRCI 3609
Query: 689 QAHW 700
W
Sbjct: 3610 PQSW 3613
Score = 47.4 bits (111), Expect = 5e-05
Identities = 27/82 (32%), Positives = 32/82 (39%), Gaps = 1/82 (1%)
Frame = +2
Query: 458 CRKGRSSADVIVLVDPICTAGSRLCRNGECINSAKFCDGKRDCADGSDEDQ-EFCRLCDP 634
C G D C A C NG CI+ CDG DC D SDEDQ C L +
Sbjct: 2891 CADGSDEPDTCGHSVNTCRASQFQCDNGRCISGNWVCDGDNDCGDMSDEDQRHHCELQNC 2950
Query: 635 LSKRCETHNGQNPTNNIYQAHW 700
S + N + P +W
Sbjct: 2951 SSTQFTCVNSRPPNRRCIPQYW 2972
Score = 45.8 bits (107), Expect = 1e-04
Identities = 19/44 (43%), Positives = 22/44 (50%)
Frame = +2
Query: 503 PICTAGSRLCRNGECINSAKFCDGKRDCADGSDEDQEFCRLCDP 634
P C A C+NG CI CD DC DGSDE + C +P
Sbjct: 3032 PPCHANQFTCQNGRCIPRFFVCDEDNDCGDGSDEQEHLCHTPEP 3075
Score = 43.9 bits (102), Expect = 5e-04
Identities = 18/37 (48%), Positives = 21/37 (56%)
Frame = +2
Query: 509 CTAGSRLCRNGECINSAKFCDGKRDCADGSDEDQEFC 619
C A C+N CI S CDG+ DC DGSDE+ C
Sbjct: 3844 CPAAMFECKNHVCIQSFWICDGENDCVDGSDEEIHLC 3880
Score = 43.5 bits (101), Expect = 7e-04
Identities = 20/57 (35%), Positives = 26/57 (45%)
Frame = +2
Query: 530 CRNGECINSAKFCDGKRDCADGSDEDQEFCRLCDPLSKRCETHNGQNPTNNIYQAHW 700
C N C+ + C+G DC DGSDE +E CR P K C + N H+
Sbjct: 3893 CDNSRCVYGHQLCNGVDDCGDGSDEKEEHCR--KPTHKPCTDTEYKCSNGNCISQHY 3947
Score = 42.7 bits (99), Expect = 0.001
Identities = 20/44 (45%), Positives = 23/44 (52%)
Frame = +2
Query: 509 CTAGSRLCRNGECINSAKFCDGKRDCADGSDEDQEFCRLCDPLS 640
C+A C NG+CI S CD DC DGSDE CD L+
Sbjct: 108 CSAQQMTCSNGQCIPSEYRCDHVSDCPDGSDERNCHYPTCDQLT 151
Score = 42.7 bits (99), Expect = 0.001
Identities = 22/46 (47%), Positives = 28/46 (60%), Gaps = 5/46 (10%)
Frame = +2
Query: 503 PICTAGSRLCRNGE-CINSAKFCDGKRDCADGSDE----DQEFCRL 625
P+C++ LC N E CI CDG++DC+DGSDE FCRL
Sbjct: 3512 PMCSSTQFLCGNNEKCIPIWWKCDGQKDCSDGSDEPDLCPHRFCRL 3557
Score = 41.6 bits (96), Expect = 0.003
Identities = 26/75 (34%), Positives = 33/75 (44%), Gaps = 2/75 (2%)
Frame = +2
Query: 449 RFTCRKGRSSADVIVLVDPICTAGSRLCRNGECINSAKFCDGKRDCADGSDEDQEFC--R 622
R C G S D ++ C + C N CI + CD DC D SDED C R
Sbjct: 3577 RQDCADG-SDEDRVLCEHHRCESNEWQCANKRCIPQSWQCDSVNDCLDNSDEDTSHCASR 3635
Query: 623 LCDPLSKRCETHNGQ 667
C P +C +NG+
Sbjct: 3636 TCRPGQFKC--NNGR 3648
Score = 40.4 bits (93), Expect = 0.006
Identities = 21/56 (37%), Positives = 25/56 (44%), Gaps = 1/56 (1%)
Frame = +2
Query: 509 CTAGSRLCRNGECINSAKFCDGKRDCADGSDEDQ-EFCRLCDPLSKRCETHNGQNP 673
C + S C N CI CD DC+DGSDE + C P RC H +P
Sbjct: 1110 CPSTSFTCDNHVCIPKDWVCDTDNDCSDGSDEKNCQASGTCQPTQFRCPDHRCISP 1165
Score = 40.4 bits (93), Expect = 0.006
Identities = 21/58 (36%), Positives = 23/58 (39%), Gaps = 14/58 (24%)
Frame = +2
Query: 530 CRNGECINSAKFCDGKRDCADGSDEDQEFCRL--------------CDPLSKRCETHN 661
C NG CIN CD DC DGSDE C C P RC+ +N
Sbjct: 2708 CLNGHCINQDWKCDNDNDCGDGSDELPTVCAFHTCRSTAFTCGNGRCVPYHYRCDYYN 2765
Score = 40.0 bits (92), Expect = 0.008
Identities = 21/49 (42%), Positives = 25/49 (51%), Gaps = 2/49 (4%)
Frame = +2
Query: 509 CTAGSRLCRNGECINSAKFCDGKRDCADGSDEDQ--EFCRLCDPLSKRC 649
C + S C NG+C+ S CDG DC D SDE Q F C P + C
Sbjct: 1025 CGSLSFPCNNGKCVPSFFRCDGVDDCHDNSDEHQCGVFNNTCSPSAFAC 1073
Score = 39.7 bits (91), Expect = 0.010
Identities = 16/33 (48%), Positives = 17/33 (51%)
Frame = +2
Query: 509 CTAGSRLCRNGECINSAKFCDGKRDCADGSDED 607
C C NG+CIN CDG DC D DED
Sbjct: 222 CGGHQFTCSNGQCINQNWVCDGDDDCQDSGDED 254
Score = 39.7 bits (91), Expect = 0.010
Identities = 18/36 (50%), Positives = 19/36 (52%)
Frame = +2
Query: 497 VDPICTAGSRLCRNGECINSAKFCDGKRDCADGSDE 604
V C+ LC NG CI A CDG DC D SDE
Sbjct: 1268 VPKTCSPTHFLCDNGNCIYKAWICDGDNDCRDMSDE 1303
Score = 39.3 bits (90), Expect = 0.013
Identities = 16/32 (50%), Positives = 21/32 (65%)
Frame = +2
Query: 509 CTAGSRLCRNGECINSAKFCDGKRDCADGSDE 604
C +G+ C NG CI ++ CDG RDC D +DE
Sbjct: 28 CGSGNFRCDNGYCIPASWRCDGTRDCLDDTDE 59
Score = 39.3 bits (90), Expect = 0.013
Identities = 15/32 (46%), Positives = 19/32 (59%)
Frame = +2
Query: 509 CTAGSRLCRNGECINSAKFCDGKRDCADGSDE 604
C+AG C NG C+ + CD + DC D SDE
Sbjct: 2995 CSAGEFSCANGRCVRQSFRCDRRNDCGDYSDE 3026
Score = 38.5 bits (88), Expect = 0.022
Identities = 22/43 (51%), Positives = 25/43 (58%), Gaps = 8/43 (18%)
Frame = +2
Query: 500 DPICTAGSRLCRNGE--------CINSAKFCDGKRDCADGSDE 604
+PI A S CR+ E CI S FCDG+ DCADGSDE
Sbjct: 2856 NPIYCA-SHTCRSNEFQCLSPQRCIPSYWFCDGEADCADGSDE 2897
Score = 38.1 bits (87), Expect = 0.029
Identities = 21/54 (38%), Positives = 29/54 (53%), Gaps = 1/54 (1%)
Frame = +2
Query: 509 CTAGSRLC-RNGECINSAKFCDGKRDCADGSDEDQEFCRLCDPLSKRCETHNGQ 667
C +G LC G CI S+ CD +DC+DG+DE Q C +++ NGQ
Sbjct: 67 CESGLFLCPAEGTCIPSSWVCDEDKDCSDGADEQQN-CAGTTCSAQQMTCSNGQ 119
Score = 37.7 bits (86), Expect = 0.037
Identities = 21/64 (32%), Positives = 28/64 (43%), Gaps = 1/64 (1%)
Frame = +2
Query: 500 DPICTAGSRLCRNGECINSAKFCDGKRDCADGSDEDQEFCRLC-DPLSKRCETHNGQNPT 676
+P C C NG CI + C+ DC+D SDE C D RC+ HN +
Sbjct: 3074 EPTCPLHQFRCDNGHCIEMGRVCNHVDDCSDNSDEKGCGINECLDSSISRCD-HNCTDTI 3132
Query: 677 NNIY 688
+ Y
Sbjct: 3133 TSFY 3136
Score = 37.4 bits (85), Expect = 0.049
Identities = 18/50 (36%), Positives = 22/50 (44%)
Frame = +2
Query: 509 CTAGSRLCRNGECINSAKFCDGKRDCADGSDEDQEFCRLCDPLSKRCETH 658
C G C NG CI + CD DC D SDE + C + C+ H
Sbjct: 3637 CRPGQFKCNNGRCIPQSWKCDVDNDCGDYSDEPIDECTTA---AYNCDNH 3683
Score = 37.4 bits (85), Expect = 0.049
Identities = 19/49 (38%), Positives = 21/49 (42%)
Frame = +2
Query: 503 PICTAGSRLCRNGECINSAKFCDGKRDCADGSDEDQEFCRLCDPLSKRC 649
P +G C N CI CDG DC D SDE+ R C RC
Sbjct: 3720 PCHPSGDFRCANHHCIPLRWKCDGTDDCGDNSDEENCVpreCSESEFRC 3768
Score = 37.0 bits (84), Expect = 0.064
Identities = 15/31 (48%), Positives = 18/31 (58%)
Frame = +2
Query: 512 TAGSRLCRNGECINSAKFCDGKRDCADGSDE 604
T C NG C N+++ CD K DC D SDE
Sbjct: 146 TCDQLTCANGACYNTSQRCDQKVDCRDSSDE 176
Score = 37.0 bits (84), Expect = 0.064
Identities = 16/46 (34%), Positives = 23/46 (50%), Gaps = 2/46 (4%)
Frame = +2
Query: 530 CRNGECINSAKFCDGKRDCADGSDEDQEFC--RLCDPLSKRCETHN 661
C NG CI + C+G +C D D++ C C P +C+T N
Sbjct: 2789 CSNGRCIPLSYVCNGINNCHDNDTSDEKNCPPHTCPPDFTKCQTTN 2834
Score = 36.6 bits (83), Expect = 0.083
Identities = 14/25 (56%), Positives = 17/25 (68%)
Frame = +2
Query: 530 CRNGECINSAKFCDGKRDCADGSDE 604
C + CI+ CDG +DCADGSDE
Sbjct: 1157 CPDHRCISPLYVCDGDKDCADGSDE 1181
Score = 36.6 bits (83), Expect = 0.083
Identities = 15/32 (46%), Positives = 19/32 (59%)
Frame = +3
Query: 705 CDGEDDCGNGFDESRCSGNVRECGGLTYQCSD 800
CDG DDCG+ DE C REC ++C+D
Sbjct: 3741 CDGTDDCGDNSDEENCV--preCSESEFRCAD 3770
Score = 36.2 bits (82), Expect = 0.11
Identities = 17/33 (51%), Positives = 19/33 (57%), Gaps = 1/33 (3%)
Frame = +2
Query: 509 CTAGSRLCRNGE-CINSAKFCDGKRDCADGSDE 604
CT+ C +G CINS CDG DC D SDE
Sbjct: 1188 CTSAQFKCADGSSCINSRYRCDGVYDCRDNSDE 1220
Score = 36.2 bits (82), Expect = 0.11
Identities = 16/47 (34%), Positives = 22/47 (46%)
Frame = +2
Query: 509 CTAGSRLCRNGECINSAKFCDGKRDCADGSDEDQEFCRLCDPLSKRC 649
C+ C + +CI S CD + DC D SDE + C P +C
Sbjct: 3761 CSESEFRCADQQCIPSRWVCDQENDCGDNSDERDCEMKTCHPEHFQC 3807
Score = 36.2 bits (82), Expect = 0.11
Identities = 13/25 (52%), Positives = 16/25 (64%)
Frame = +2
Query: 530 CRNGECINSAKFCDGKRDCADGSDE 604
C +G C+ A CDG+ DC D SDE
Sbjct: 3807 CTSGHCVPKALACDGRADCLDASDE 3831
Score = 35.8 bits (81), Expect = 0.14
Identities = 19/49 (38%), Positives = 22/49 (44%)
Frame = +2
Query: 458 CRKGRSSADVIVLVDPICTAGSRLCRNGECINSAKFCDGKRDCADGSDE 604
CR A+ L C+ C +GECI A CD DC D SDE
Sbjct: 170 CRDSSDEANCTTL----CSQKEFECGSGECILRAYVCDHDNDCEDNSDE 214
Score = 35.8 bits (81), Expect = 0.14
Identities = 19/55 (34%), Positives = 24/55 (43%), Gaps = 5/55 (9%)
Frame = +2
Query: 509 CTAGSRLC-RNGECINSAKFCDGKRDCADGSDED----QEFCRLCDPLSKRCETH 658
C+ + C R G+CI CD + DC DGSDE C S C+ H
Sbjct: 1066 CSPSAFACVRGGQCIPGQWHCDRQNDCLDGSDEQNCPTHATSSTCPSTSFTCDNH 1120
Score = 35.8 bits (81), Expect = 0.14
Identities = 14/34 (41%), Positives = 21/34 (61%)
Frame = +3
Query: 705 CDGEDDCGNGFDESRCSGNVRECGGLTYQCSDGT 806
CDG+ DC +G DE+ C V C ++C+DG+
Sbjct: 1169 CDGDKDCADGSDEAGC---VLNCTSAQFKCADGS 1199
Score = 35.8 bits (81), Expect = 0.14
Identities = 13/25 (52%), Positives = 16/25 (64%)
Frame = +2
Query: 545 CINSAKFCDGKRDCADGSDEDQEFC 619
C+ A CDG DC DGSDE+ +C
Sbjct: 2836 CVPRAFLCDGDNDCGDGSDENPIYC 2860
Score = 35.8 bits (81), Expect = 0.14
Identities = 15/34 (44%), Positives = 19/34 (55%), Gaps = 1/34 (2%)
Frame = +3
Query: 705 CDGEDDCGNGFDE-SRCSGNVRECGGLTYQCSDG 803
CDGE DC +G DE C +V C +QC +G
Sbjct: 2885 CDGEADCADGSDEPDTCGHSVNTCRASQFQCDNG 2918
Score = 35.4 bits (80), Expect = 0.19
Identities = 15/32 (46%), Positives = 16/32 (50%)
Frame = +2
Query: 509 CTAGSRLCRNGECINSAKFCDGKRDCADGSDE 604
CT C NG CI+ CD DC D SDE
Sbjct: 3930 CTDTEYKCSNGNCISQHYVCDNVNDCGDLSDE 3961
Score = 33.5 bits (75), Expect = 0.71
Identities = 14/33 (42%), Positives = 19/33 (57%)
Frame = +3
Query: 705 CDGEDDCGNGFDESRCSGNVRECGGLTYQCSDG 803
CD ++DC + DE C N CGG + CS+G
Sbjct: 202 CDHDNDCEDNSDERNC--NYDTCGGHQFTCSNG 232
Score = 33.5 bits (75), Expect = 0.71
Identities = 21/72 (29%), Positives = 28/72 (38%), Gaps = 2/72 (2%)
Frame = +2
Query: 452 FTCRKGRSSADVIVLVDPICTAGSRLCR-NGECINSAKFCDGKRDCADGSDEDQEFC-RL 625
+ CR A +C C+ +G CI + CDG DC GSDE +
Sbjct: 1212 YDCRDNSDEAGCPTRPPGMCHPDEFQCQGDGTCIPNTWECDGHPDCIHGSDEHTGCVPKT 1271
Query: 626 CDPLSKRCETHN 661
C P C+ N
Sbjct: 1272 CSPTHFLCDNGN 1283
Score = 33.5 bits (75), Expect = 0.71
Identities = 20/45 (44%), Positives = 22/45 (48%), Gaps = 4/45 (8%)
Frame = +3
Query: 681 TFIKHTGACDGEDDCGNGFDESRCSGNVREC----GGLTYQCSDG 803
T I + CDG DC NG DES N C GG T+QC G
Sbjct: 1325 TCINLSALCDGVFDCPNGTDESPLC-NQDSCSHFNGGCTHQCMQG 1368
Score = 32.3 bits (72), Expect = 1.6
Identities = 12/24 (50%), Positives = 16/24 (66%)
Frame = +2
Query: 536 NGECINSAKFCDGKRDCADGSDED 607
+G CI+ K CDG DC +G DE+
Sbjct: 275 SGRCISIDKVCDGVPDCPEGDDEN 298
Score = 32.3 bits (72), Expect = 1.6
Identities = 15/41 (36%), Positives = 19/41 (46%)
Frame = +2
Query: 509 CTAGSRLCRNGECINSAKFCDGKRDCADGSDEDQEFCRLCD 631
C + + C NG C+ CD DC D SDE R C+
Sbjct: 2742 CRSTAFTCGNGRCVPYHYRCDYYNDCGDNSDEAGCLFRNCN 2782
Score = 31.2 bits (69), Expect = 3.5
Identities = 12/30 (40%), Positives = 17/30 (56%)
Frame = +3
Query: 705 CDGEDDCGNGFDESRCSGNVRECGGLTYQC 794
CDG++DCG+G DE+ C +QC
Sbjct: 2843 CDGDNDCGDGSDENPIYCASHTCRSNEFQC 2872
Score = 31.2 bits (69), Expect = 3.5
Identities = 13/33 (39%), Positives = 19/33 (57%)
Frame = +3
Query: 705 CDGEDDCGNGFDESRCSGNVRECGGLTYQCSDG 803
CD E+DCG+ DE C ++ C +QC+ G
Sbjct: 3780 CDQENDCGDNSDERDC--EMKTCHPEHFQCTSG 3810
Score = 31.2 bits (69), Expect = 3.5
Identities = 15/36 (41%), Positives = 20/36 (55%), Gaps = 3/36 (8%)
Frame = +3
Query: 705 CDGEDDCGNGFD--ESRC-SGNVRECGGLTYQCSDG 803
C+G DDCG+G D E C + C Y+CS+G
Sbjct: 3905 CNGVDDCGDGSDEKEEHCRKPTHKPCTDTEYKCSNG 3940
Score = 30.8 bits (68), Expect = 4.6
Identities = 17/40 (42%), Positives = 21/40 (52%)
Frame = +2
Query: 545 CINSAKFCDGKRDCADGSDEDQEFCRLCDPLSKRCETHNG 664
CIN + CDG DC +G+DE LC+ S C NG
Sbjct: 1326 CINLSALCDGVFDCPNGTDESP----LCNQDS--CSHFNG 1359
Score = 30.0 bits (66), Expect = 7.8
Identities = 11/25 (44%), Positives = 13/25 (52%)
Frame = +3
Query: 687 IKHTGACDGEDDCGNGFDESRCSGN 761
I CDG+DDC + DE C N
Sbjct: 235 INQNWVCDGDDDCQDSGDEDGCESN 259
>sp|Q92673|SORL_HUMAN Sortilin-related receptor precursor (Sorting protein-related receptor
containing LDLR class A repeats) (SorLA) (SorLA-1)
(Low-density lipoprotein receptor relative with 11
ligand-binding repeats) (LDLR relative with 11
ligand-binding repeats) (LR11)
Length = 2214
Score = 49.3 bits (116), Expect = 1e-05
Identities = 25/59 (42%), Positives = 27/59 (45%), Gaps = 11/59 (18%)
Frame = +2
Query: 509 CTAGSRLCRNGECINSAKFCDGKRDCADGSDEDQEFCR-----------LCDPLSKRCE 652
C A + CRNG CI CDG DC DGSDED C C P SK C+
Sbjct: 1199 CEASNFQCRNGHCIPQRWACDGDTDCQDGSDEDPVNCEKKCNGFRCPNGTCIPSSKHCD 1257
Score = 47.4 bits (111), Expect = 5e-05
Identities = 21/36 (58%), Positives = 24/36 (66%)
Frame = +2
Query: 530 CRNGECINSAKFCDGKRDCADGSDEDQEFCRLCDPL 637
C NG CI S+K CDG RDC+DGSDE C+PL
Sbjct: 1244 CPNGTCIPSSKHCDGLRDCSDGSDEQH-----CEPL 1274
Score = 41.6 bits (96), Expect = 0.003
Identities = 27/79 (34%), Positives = 35/79 (44%), Gaps = 16/79 (20%)
Frame = +2
Query: 509 CTAGSRLCRNGECINSAKFCDGKRDCADGSDE----------DQEF-CR---LCDPLSKR 646
C C NG CINS +CD DC D SDE D +F C+ C PLS +
Sbjct: 1078 CLRNQYRCSNGNCINSIWWCDFDNDCGDMSDERNCPTTICDLDTQFRCQESGTCIPLSYK 1137
Query: 647 CETHN--GQNPTNNIYQAH 697
C+ + G N + + H
Sbjct: 1138 CDLEDDCGDNSDESHCEMH 1156
Score = 40.8 bits (94), Expect = 0.004
Identities = 21/64 (32%), Positives = 26/64 (40%)
Frame = +2
Query: 509 CTAGSRLCRNGECINSAKFCDGKRDCADGSDEDQEFCRLCDPLSKRCETHNGQNPTNNIY 688
C + C +G CI S+ CDG DC D SDE C + CE N Q +
Sbjct: 1158 CRSDEYNCSSGMCIRSSWVCDGDNDCRDWSDEAN-----CTAIYHTCEASNFQCRNGHCI 1212
Query: 689 QAHW 700
W
Sbjct: 1213 PQRW 1216
Score = 40.4 bits (93), Expect = 0.006
Identities = 16/33 (48%), Positives = 19/33 (57%)
Frame = +2
Query: 509 CTAGSRLCRNGECINSAKFCDGKRDCADGSDED 607
C C +G C+ CDG RDCADGSDE+
Sbjct: 1419 CLPNYYRCSSGTCVMDTWVCDGYRDCADGSDEE 1451
Score = 38.1 bits (87), Expect = 0.029
Identities = 18/45 (40%), Positives = 24/45 (53%), Gaps = 1/45 (2%)
Frame = +3
Query: 672 QPITFIKHTGACDGEDDCGNGFDESRC-SGNVRECGGLTYQCSDG 803
QP T I + CDG DC +G DE+ C + + C +QC DG
Sbjct: 1480 QPKTCIPNWKRCDGHQDCQDGRDEANCPTHSTLTCMSREFQCEDG 1524
Score = 37.7 bits (86), Expect = 0.037
Identities = 21/62 (33%), Positives = 32/62 (51%), Gaps = 11/62 (17%)
Frame = +2
Query: 500 DPICTAGSR-LCRNGE-CINSAKFCDGKRDCADGSDE---------DQEFCRLCDPLSKR 646
+P+CT +C+N + C+ + CDG C DGSDE D EF ++CD +
Sbjct: 1272 EPLCTHFMDFVCKNRQQCLFHSMVCDGIIQCRDGSDEDAAFAGCSQDPEFHKVCDEFGFQ 1331
Query: 647 CE 652
C+
Sbjct: 1332 CQ 1333
Score = 37.0 bits (84), Expect = 0.064
Identities = 16/33 (48%), Positives = 19/33 (57%)
Frame = +3
Query: 705 CDGEDDCGNGFDESRCSGNVRECGGLTYQCSDG 803
CD EDDCG+ DES C + +C Y CS G
Sbjct: 1138 CDLEDDCGDNSDESHC--EMHQCRSDEYNCSSG 1168
Score = 36.6 bits (83), Expect = 0.083
Identities = 13/39 (33%), Positives = 22/39 (56%)
Frame = +3
Query: 687 IKHTGACDGEDDCGNGFDESRCSGNVRECGGLTYQCSDG 803
I+ + CDG++DC + DE+ C+ C +QC +G
Sbjct: 1171 IRSSWVCDGDNDCRDWSDEANCTAIYHTCEASNFQCRNG 1209
Score = 35.4 bits (80), Expect = 0.19
Identities = 19/50 (38%), Positives = 26/50 (52%), Gaps = 1/50 (2%)
Frame = +2
Query: 458 CRKGRSSADVIVLVDPICTAGSRLCRNGE-CINSAKFCDGKRDCADGSDE 604
C+ GR A+ C + C +GE CI ++ CDG DC+D SDE
Sbjct: 1497 CQDGRDEANCPTHSTLTCMSREFQCEDGEACIVLSERCDGFLDCSDESDE 1546
Score = 34.7 bits (78), Expect = 0.32
Identities = 15/33 (45%), Positives = 18/33 (54%)
Frame = +2
Query: 506 ICTAGSRLCRNGECINSAKFCDGKRDCADGSDE 604
+C C+NG CI+ CDG DC D SDE
Sbjct: 1324 VCDEFGFQCQNGVCISLIWKCDGMDDCGDYSDE 1356
Score = 33.1 bits (74), Expect = 0.92
Identities = 13/25 (52%), Positives = 15/25 (60%)
Frame = +2
Query: 530 CRNGECINSAKFCDGKRDCADGSDE 604
C NG CI + CD + DC D SDE
Sbjct: 1376 CENGHCIPNRWKCDRENDCGDWSDE 1400
Score = 30.8 bits (68), Expect = 4.6
Identities = 12/20 (60%), Positives = 14/20 (70%)
Frame = +2
Query: 545 CINSAKFCDGKRDCADGSDE 604
CI + K CDG +DC DG DE
Sbjct: 1484 CIPNWKRCDGHQDCQDGRDE 1503
Score = 30.4 bits (67), Expect = 6.0
Identities = 14/35 (40%), Positives = 22/35 (62%)
Frame = +3
Query: 702 ACDGEDDCGNGFDESRCSGNVRECGGLTYQCSDGT 806
ACDG+ DC +G DE + ++C G ++C +GT
Sbjct: 1217 ACDGDTDCQDGSDEDPVNCE-KKCNG--FRCPNGT 1248
>sp|Q04833|LRP_CAEEL Low-density lipoprotein receptor-related protein precursor (LRP)
Length = 4753
Score = 48.5 bits (114), Expect = 2e-05
Identities = 25/60 (41%), Positives = 27/60 (45%), Gaps = 2/60 (3%)
Frame = +2
Query: 509 CTAGSRLCRNGECINSAKFCDGKRDCADGSDEDQEFCR--LCDPLSKRCETHNGQNPTNN 682
C A C NG CI CDG DC DG+DED+E C C L RC P N
Sbjct: 1187 CAANQFSCANGRCIPIYWLCDGDNDCYDGTDEDKERCPPVQCSALQFRCANGRQCVPLRN 1246
Score = 47.4 bits (111), Expect = 5e-05
Identities = 23/64 (35%), Positives = 27/64 (42%)
Frame = +2
Query: 458 CRKGRSSADVIVLVDPICTAGSRLCRNGECINSAKFCDGKRDCADGSDEDQEFCRLCDPL 637
CR G + IC G C N C + CDG DC D SDE Q + CDP
Sbjct: 3654 CRDGSDEPGESICGQRICPVGEFQCTNHNCTRPFQICDGNDDCGDSSDE-QNCDKACDPW 3712
Query: 638 SKRC 649
+C
Sbjct: 3713 MFKC 3716
Score = 45.8 bits (107), Expect = 1e-04
Identities = 19/48 (39%), Positives = 27/48 (56%)
Frame = +2
Query: 509 CTAGSRLCRNGECINSAKFCDGKRDCADGSDEDQEFCRLCDPLSKRCE 652
C+ C +G+CI +K CDG C+DG DE Q R C P ++C+
Sbjct: 3878 CSESEFRCNDGKCIPGSKVCDGTIQCSDGLDESQCTLRRCLPGHRQCD 3925
Score = 45.4 bits (106), Expect = 2e-04
Identities = 22/51 (43%), Positives = 26/51 (50%), Gaps = 1/51 (1%)
Frame = +2
Query: 509 CTAGSRLCRN-GECINSAKFCDGKRDCADGSDEDQEFCRLCDPLSKRCETH 658
C G C G CI+ K CDG +DCADG+DE Q LC L + H
Sbjct: 262 CPPGKWNCPGTGHCIDQLKLCDGSKDCADGADEQQCSQNLCPSLGCQAGCH 312
Score = 44.7 bits (104), Expect = 3e-04
Identities = 36/135 (26%), Positives = 51/135 (37%), Gaps = 27/135 (20%)
Frame = +2
Query: 335 FMANGGRASDSQRTTVEKLEAGKVQLTYRAVTTNDNGTRFTCRKGR---------SSADV 487
FM N Q+ EK+E + N T+F C+ GR D
Sbjct: 1032 FMINKENNHSCQKDPAEKIEQ----------LCSSNSTQFQCKNGRCIPKEWKCDGENDC 1081
Query: 488 IVLVDPI------------CTAGSRLCRNGE-CINSAKFCDGKRDCADGSDEDQEFCR-- 622
+ D I C + CRN + CI + CDG DC D SDED ++C+
Sbjct: 1082 LDESDEIDEKGDKCFHETECAENTIKCRNTKKCIPAQYGCDGDNDCGDYSDEDVKYCKDG 1141
Query: 623 ---LCDPLSKRCETH 658
+C +C+ H
Sbjct: 1142 QKPVCAAKKFQCDNH 1156
Score = 43.9 bits (102), Expect = 5e-04
Identities = 21/55 (38%), Positives = 26/55 (47%)
Frame = +2
Query: 449 RFTCRKGRSSADVIVLVDPICTAGSRLCRNGECINSAKFCDGKRDCADGSDEDQE 613
+F C GR C++ C NG CI + CDG+ DC DGSDE E
Sbjct: 1304 KFGCTSGRQ-----------CSSDQFKCGNGRCILNNWLCDGENDCGDGSDESSE 1347
Score = 43.9 bits (102), Expect = 5e-04
Identities = 31/88 (35%), Positives = 40/88 (45%), Gaps = 11/88 (12%)
Frame = +2
Query: 443 GTRFTCRKGRSSADVIVLV------DPICTAGSRLCR--NGECINSAKFCDGKRDCADGS 598
G +TC S D VL+ +P CT C + +CI +CDG+ DC DGS
Sbjct: 3603 GNGYTC----SCPDQFVLLSDQKTCEPNCTERQFACGGDDAKCIPKLWYCDGEPDCRDGS 3658
Query: 599 DEDQE-FC--RLCDPLSKRCETHNGQNP 673
DE E C R+C +C HN P
Sbjct: 3659 DEPGESICGQRICPVGEFQCTNHNCTRP 3686
Score = 43.9 bits (102), Expect = 5e-04
Identities = 21/51 (41%), Positives = 29/51 (56%), Gaps = 2/51 (3%)
Frame = +2
Query: 509 CTAGSRLCRNG-ECINSAKFCDGKRDCADGSDEDQEFCRLCDPLSK-RCET 655
C G C + CI + FC+G+ DC D SDED++ C CD + + RC T
Sbjct: 3793 CKKGWTRCSSSYRCIPNWAFCNGQDDCRDNSDEDKQRCPTCDDVGEFRCAT 3843
Score = 43.5 bits (101), Expect = 7e-04
Identities = 22/59 (37%), Positives = 25/59 (42%)
Frame = +2
Query: 509 CTAGSRLCRNGECINSAKFCDGKRDCADGSDEDQEFCRLCDPLSKRCETHNGQNPTNNI 685
C G+ C NG CIN K CDG DC D D+ C L C + P NI
Sbjct: 2874 CAEGTFPCSNGHCINQTKVCDGHNDCHDEQVSDESLA-TCPGLPIDCRGVKVRCPNTNI 2931
Score = 42.7 bits (99), Expect = 0.001
Identities = 25/70 (35%), Positives = 29/70 (41%), Gaps = 2/70 (2%)
Frame = +2
Query: 455 TCRKGRS-SADVIVLVDPICTAGSRLCRNGECINSAKFCDGKRDCADGSDEDQEFC-RLC 628
TC G S ++ C G C N CI+S CDG DC DGSDE C
Sbjct: 3081 TCAGGEDESTELCKTEKKECNKGEFRCSNQHCIHSTWECDGDNDCLDGSDEHANCTYSSC 3140
Query: 629 DPLSKRCETH 658
P +C H
Sbjct: 3141 QPDFFQCANH 3150
Score = 42.4 bits (98), Expect = 0.002
Identities = 18/39 (46%), Positives = 19/39 (48%)
Frame = +2
Query: 503 PICTAGSRLCRNGECINSAKFCDGKRDCADGSDEDQEFC 619
P+C A C N CI CD DC DGSDE E C
Sbjct: 1144 PVCAAKKFQCDNHRCIPEQWKCDSDNDCGDGSDEKLEMC 1182
Score = 42.4 bits (98), Expect = 0.002
Identities = 26/77 (33%), Positives = 32/77 (41%), Gaps = 8/77 (10%)
Frame = +2
Query: 449 RFTCRKGRSSADVIVLVDPICTAGSR-------LCRNGECINSAKFCDGKRDCADGSDED 607
RFTC D D +C + R C N +CI A CD DC DGSDE
Sbjct: 3726 RFTCDGDDDCGDRSDEADTLCMSAERNCTAEEFRCNNNKCIAKAWRCDNDDDCGDGSDET 3785
Query: 608 QEFCRL-CDPLSKRCET 655
E ++ C RC +
Sbjct: 3786 PECAQIECKKGWTRCSS 3802
Score = 42.0 bits (97), Expect = 0.002
Identities = 19/50 (38%), Positives = 25/50 (50%), Gaps = 3/50 (6%)
Frame = +2
Query: 509 CTAGSRLCRNGECINSAKFCDGKRDCADGSDE---DQEFCRLCDPLSKRC 649
C G R C +G CI K+CD K+DC + +DE + R C P C
Sbjct: 3917 CLPGHRQCDDGTCIAEHKWCDRKKDCPNAADELHCEDVSRRTCSPFEFEC 3966
Score = 41.2 bits (95), Expect = 0.003
Identities = 17/32 (53%), Positives = 20/32 (62%)
Frame = +2
Query: 509 CTAGSRLCRNGECINSAKFCDGKRDCADGSDE 604
C+ G C +GECI+ AK CD DC D SDE
Sbjct: 3187 CSNGQFQCTSGECIDDAKVCDRNFDCTDRSDE 3218
Score = 40.4 bits (93), Expect = 0.006
Identities = 24/64 (37%), Positives = 30/64 (46%), Gaps = 16/64 (25%)
Frame = +2
Query: 509 CTAGSRLCRNG-ECINSAKFCDGKRDCADGSDEDQ-----EFCR----------LCDPLS 640
C+A C NG +C+ CDG+ DC DGSDED E C LC P S
Sbjct: 1228 CSALQFRCANGRQCVPLRNHCDGQSDCEDGSDEDSCAVTAESCTPDQFKCVSSGLCIPAS 1287
Query: 641 KRCE 652
+C+
Sbjct: 1288 WKCD 1291
Score = 40.4 bits (93), Expect = 0.006
Identities = 21/43 (48%), Positives = 21/43 (48%), Gaps = 3/43 (6%)
Frame = +2
Query: 530 CRNGECINSAKFCDGKRDCADGSDEDQEFCR--LCD-PLSKRC 649
C N CI CDG DC D SDE CR CD PL RC
Sbjct: 3966 CANSVCIPRKFMCDGDNDCGDNSDETSSECRSAQCDPPLRFRC 4008
Score = 40.0 bits (92), Expect = 0.008
Identities = 15/32 (46%), Positives = 19/32 (59%)
Frame = +2
Query: 509 CTAGSRLCRNGECINSAKFCDGKRDCADGSDE 604
C++ C NG+C+N CD K DC D SDE
Sbjct: 4049 CSSDQFKCANGKCVNGTVACDRKDDCGDASDE 4080
Score = 39.7 bits (91), Expect = 0.010
Identities = 18/52 (34%), Positives = 26/52 (50%)
Frame = +2
Query: 545 CINSAKFCDGKRDCADGSDEDQEFCRLCDPLSKRCETHNGQNPTNNIYQAHW 700
CI A CDG DC D +DE+Q FC ++++C H + P+ W
Sbjct: 2932 CIQPADLCDGYDDCGDKADENQLFC-----MNQQCAQHYVRCPSGRCIPETW 2978
Score = 38.9 bits (89), Expect = 0.017
Identities = 17/51 (33%), Positives = 25/51 (49%)
Frame = +2
Query: 506 ICTAGSRLCRNGECINSAKFCDGKRDCADGSDEDQEFCRLCDPLSKRCETH 658
+C C +G+CI + CDG DC+DG DE C +C+T+
Sbjct: 52 VCNENDFRCNDGKCIRTEWKCDGSGDCSDGEDEKDCPHPGCKSDQWQCDTY 102
Score = 38.9 bits (89), Expect = 0.017
Identities = 15/30 (50%), Positives = 18/30 (60%)
Frame = +2
Query: 530 CRNGECINSAKFCDGKRDCADGSDEDQEFC 619
C +G CI CD K DCAD SDE+ +C
Sbjct: 2800 CGDGSCILLGATCDSKPDCADASDENPNYC 2829
Score = 38.9 bits (89), Expect = 0.017
Identities = 17/32 (53%), Positives = 19/32 (59%)
Frame = +2
Query: 509 CTAGSRLCRNGECINSAKFCDGKRDCADGSDE 604
C LC N CI+SAK C+ DC DGSDE
Sbjct: 2834 CPEDYNLCTNRRCIDSAKKCNHIDDCGDGSDE 2865
Score = 38.5 bits (88), Expect = 0.022
Identities = 28/79 (35%), Positives = 37/79 (46%), Gaps = 4/79 (5%)
Frame = +2
Query: 458 CRKGRSSADVIVLVDPICTAGSRLC-RNGECINSAKFCDGKRDCADGSDEDQEFC---RL 625
C G S D + CT C +G CI ++ CDG++DC DGSDE + C R
Sbjct: 1254 CEDG-SDEDSCAVTAESCTPDQFKCVSSGLCIPASWKCDGQQDCDDGSDEPKFGCTSGRQ 1312
Query: 626 CDPLSKRCETHNGQNPTNN 682
C +C NG+ NN
Sbjct: 1313 CSSDQFKC--GNGRCILNN 1329
Score = 37.7 bits (86), Expect = 0.037
Identities = 15/25 (60%), Positives = 18/25 (72%)
Frame = +2
Query: 530 CRNGECINSAKFCDGKRDCADGSDE 604
C N +CI+ A CDG+ DC DGSDE
Sbjct: 3014 CDNLKCISRAFICDGEDDCGDGSDE 3038
Score = 37.7 bits (86), Expect = 0.037
Identities = 21/64 (32%), Positives = 33/64 (51%), Gaps = 1/64 (1%)
Frame = +2
Query: 509 CTAGSRLCR-NGECINSAKFCDGKRDCADGSDEDQEFCRLCDPLSKRCETHNGQNPTNNI 685
CT+ ++L + ECI A CDG CA G DE E C+ +++ E + G+ +N
Sbjct: 3056 CTSNAKLAQPKYECIPRAWLCDGDVTCAGGEDESTELCK-----TEKKECNKGEFRCSNQ 3110
Query: 686 YQAH 697
+ H
Sbjct: 3111 HCIH 3114
Score = 37.7 bits (86), Expect = 0.037
Identities = 15/35 (42%), Positives = 21/35 (60%), Gaps = 2/35 (5%)
Frame = +3
Query: 705 CDGEDDCGNGFDE--SRCSGNVRECGGLTYQCSDG 803
CD E+DCG+ DE + C G R C ++C+DG
Sbjct: 3854 CDTENDCGDNSDELDASCGGTTRPCSESEFRCNDG 3888
Score = 36.2 bits (82), Expect = 0.11
Identities = 20/53 (37%), Positives = 27/53 (50%), Gaps = 13/53 (24%)
Frame = +2
Query: 542 ECINSAKFCDGKRDCADGSDEDQ--EF--C---------RLCDPLSKRCETHN 661
+CI + CDG +DCADGSDE EF C + C P RC+ ++
Sbjct: 194 QCIQKSWVCDGSKDCADGSDEPDTCEFKKCTANEFQCKNKRCQPRKFRCDYYD 246
Score = 36.2 bits (82), Expect = 0.11
Identities = 17/36 (47%), Positives = 20/36 (55%), Gaps = 1/36 (2%)
Frame = +3
Query: 705 CDGEDDCGNGFDE-SRCSGNVRECGGLTYQCSDGTK 809
CDGEDDCG+G DE SR R C + C+ K
Sbjct: 3026 CDGEDDCGDGSDEHSRHGCGNRTCTDQEFHCTSNAK 3061
Score = 35.0 bits (79), Expect = 0.24
Identities = 14/30 (46%), Positives = 16/30 (53%)
Frame = +2
Query: 530 CRNGECINSAKFCDGKRDCADGSDEDQEFC 619
C +G CI CDG DC+DG DE C
Sbjct: 2968 CPSGRCIPETWQCDGDNDCSDGWDETHTNC 2997
Score = 35.0 bits (79), Expect = 0.24
Identities = 13/25 (52%), Positives = 17/25 (68%)
Frame = +2
Query: 530 CRNGECINSAKFCDGKRDCADGSDE 604
C N +C+ ++ CDG DC DGSDE
Sbjct: 3147 CANHKCVPNSWKCDGNDDCEDGSDE 3171
Score = 34.7 bits (78), Expect = 0.32
Identities = 18/47 (38%), Positives = 20/47 (42%)
Frame = +2
Query: 509 CTAGSRLCRNGECINSAKFCDGKRDCADGSDEDQEFCRLCDPLSKRC 649
CTA C+N C CD DC D SDED+ C P C
Sbjct: 223 CTANEFQCKNKRCQPRKFRCDYYDDCGDNSDEDECGEYRCPPGKWNC 269
Score = 34.7 bits (78), Expect = 0.32
Identities = 15/45 (33%), Positives = 22/45 (48%), Gaps = 6/45 (13%)
Frame = +3
Query: 687 IKHTGACDGEDDCGNGFDESRCSGN------VRECGGLTYQCSDG 803
+ ++ CDG DDC +G DE C N +C +QC+ G
Sbjct: 3153 VPNSWKCDGNDDCEDGSDEKDCPKNSASAQKASKCSNGQFQCTSG 3197
Score = 34.7 bits (78), Expect = 0.32
Identities = 16/34 (47%), Positives = 20/34 (58%)
Frame = +3
Query: 705 CDGEDDCGNGFDESRCSGNVRECGGLTYQCSDGT 806
CDG C +G DES+C+ +R C QC DGT
Sbjct: 3897 CDGTIQCSDGLDESQCT--LRRCLPGHRQCDDGT 3928
Score = 33.5 bits (75), Expect = 0.71
Identities = 15/28 (53%), Positives = 19/28 (67%), Gaps = 5/28 (17%)
Frame = +3
Query: 705 CDGEDDCGNGFDES-----RCSGNVREC 773
CDGE+DCG+G DES + S N R+C
Sbjct: 1332 CDGENDCGDGSDESSERGCKTSMNARKC 1359
Score = 33.1 bits (74), Expect = 0.92
Identities = 15/33 (45%), Positives = 20/33 (60%), Gaps = 1/33 (3%)
Frame = +2
Query: 527 LCRNG-ECINSAKFCDGKRDCADGSDEDQEFCR 622
+C +G +C + +K CDGK DC D SDE R
Sbjct: 145 MCADGRQCFDVSKKCDGKYDCRDLSDEKDSCSR 177
Score = 33.1 bits (74), Expect = 0.92
Identities = 12/33 (36%), Positives = 21/33 (63%)
Frame = +3
Query: 705 CDGEDDCGNGFDESRCSGNVRECGGLTYQCSDG 803
CDG++DC +G DE + +C L ++C++G
Sbjct: 1206 CDGDNDCYDGTDEDKERCPPVQCSALQFRCANG 1238
Score = 33.1 bits (74), Expect = 0.92
Identities = 18/46 (39%), Positives = 23/46 (50%), Gaps = 8/46 (17%)
Frame = +3
Query: 687 IKHTGACDGEDDCGNGFDESRCS--GNVREC------GGLTYQCSD 800
+ T ACD +DDCG+ DE CS G C GG + C+D
Sbjct: 4062 VNGTVACDRKDDCGDASDEIGCSKHGGKTSCEAFGNNGGCKHICTD 4107
Score = 32.7 bits (73), Expect = 1.2
Identities = 17/46 (36%), Positives = 20/46 (43%), Gaps = 4/46 (8%)
Frame = +2
Query: 524 RLCRNGECINSAKFCDGKRDCADGSDEDQEFC----RLCDPLSKRC 649
R +G+CI CD + DC D SDE C R C RC
Sbjct: 3840 RCATSGKCIPRRWMCDTENDCGDNSDELDASCGGTTRPCSESEFRC 3885
Score = 32.0 bits (71), Expect = 2.1
Identities = 11/30 (36%), Positives = 16/30 (53%)
Frame = +3
Query: 705 CDGEDDCGNGFDESRCSGNVRECGGLTYQC 794
CDG+ DC +G DE C+ C ++C
Sbjct: 1248 CDGQSDCEDGSDEDSCAVTAESCTPDQFKC 1277
Score = 32.0 bits (71), Expect = 2.1
Identities = 15/33 (45%), Positives = 19/33 (57%)
Frame = +3
Query: 705 CDGEDDCGNGFDESRCSGNVRECGGLTYQCSDG 803
C+ DDCG+G DE C V C T+ CS+G
Sbjct: 2853 CNHIDDCGDGSDELDCPSAV-ACAEGTFPCSNG 2884
Score = 32.0 bits (71), Expect = 2.1
Identities = 12/31 (38%), Positives = 17/31 (54%)
Frame = +3
Query: 705 CDGEDDCGNGFDESRCSGNVRECGGLTYQCS 797
CDG DDCG+ DE C + C ++C+
Sbjct: 3690 CDGNDDCGDSSDEQNCD---KACDPWMFKCA 3717
Score = 32.0 bits (71), Expect = 2.1
Identities = 17/44 (38%), Positives = 18/44 (40%), Gaps = 4/44 (9%)
Frame = +2
Query: 539 GECINSAKFCDGKRDCADGSDEDQEFC----RLCDPLSKRCETH 658
G CI CDG DC D SDE C R C RC +
Sbjct: 3720 GRCIPRRFTCDGDDDCGDRSDEADTLCMSAERNCTAEEFRCNNN 3763
Score = 32.0 bits (71), Expect = 2.1
Identities = 13/34 (38%), Positives = 20/34 (58%), Gaps = 2/34 (5%)
Frame = +3
Query: 705 CDGEDDCGNGFDE--SRCSGNVRECGGLTYQCSD 800
CDG+DDCG+ DE + C R C ++C++
Sbjct: 3729 CDGDDDCGDRSDEADTLCMSAERNCTAEEFRCNN 3762
Score = 31.6 bits (70), Expect = 2.7
Identities = 11/20 (55%), Positives = 14/20 (70%)
Frame = +3
Query: 705 CDGEDDCGNGFDESRCSGNV 764
CDG DC +G DE +CS N+
Sbjct: 282 CDGSKDCADGADEQQCSQNL 301
Score = 31.6 bits (70), Expect = 2.7
Identities = 13/35 (37%), Positives = 21/35 (60%), Gaps = 2/35 (5%)
Frame = +3
Query: 705 CDGEDDCGNGFDESR--CSGNVRECGGLTYQCSDG 803
CDG+ DC +G DE + C+ R+C ++C +G
Sbjct: 1290 CDGQQDCDDGSDEPKFGCTSG-RQCSSDQFKCGNG 1323
Score = 30.8 bits (68), Expect = 4.6
Identities = 12/34 (35%), Positives = 17/34 (50%), Gaps = 1/34 (2%)
Frame = +3
Query: 705 CDGEDDCGNGFDESRCSGNVRECGGL-TYQCSDG 803
CD DC +G DE C + +C + C+DG
Sbjct: 116 CDNITDCADGSDEKDCPASTVDCSSQNVFMCADG 149
Score = 30.4 bits (67), Expect = 6.0
Identities = 19/52 (36%), Positives = 23/52 (44%), Gaps = 5/52 (9%)
Frame = +2
Query: 530 CRNGE--CINSAKFCDGKRDCADGSDEDQEFCR-LCDPLSKRC--ETHNGQN 670
C N + CI + CDGK C G+DE R LC C + HN N
Sbjct: 1366 CENDQETCIPLHQLCDGKTHCPGGTDEGGRCARDLCSADRAGCSFKCHNSPN 1417
>sp|Q9JI18|LRP1B_MOUSE Low-density lipoprotein receptor-related protein 1B precursor
(Low-density lipoprotein receptor-related protein-deleted
in tumor) (LRP-DIT)
Length = 4599
Score = 48.5 bits (114), Expect = 2e-05
Identities = 23/49 (46%), Positives = 28/49 (57%)
Frame = +2
Query: 509 CTAGSRLCRNGECINSAKFCDGKRDCADGSDEDQEFCRLCDPLSKRCET 655
CT LC NG+C++S +CDG+ DCADGSDE K CET
Sbjct: 3515 CTLKDFLCSNGDCVSSRFWCDGEFDCADGSDE------------KNCET 3551
Score = 44.7 bits (104), Expect = 3e-04
Identities = 19/38 (50%), Positives = 21/38 (55%)
Frame = +2
Query: 506 ICTAGSRLCRNGECINSAKFCDGKRDCADGSDEDQEFC 619
IC G C+N CI + CDG DC DGSDED C
Sbjct: 844 ICKPGEFRCKNKHCIQARWKCDGDDDCLDGSDEDSVTC 881
Score = 44.3 bits (103), Expect = 4e-04
Identities = 20/62 (32%), Positives = 28/62 (45%)
Frame = +2
Query: 464 KGRSSADVIVLVDPICTAGSRLCRNGECINSAKFCDGKRDCADGSDEDQEFCRLCDPLSK 643
K +S ++ + C +G + C N C+ K CDG DC D SDE C +
Sbjct: 2537 KDKSDEKLLYCENRSCRSGFKPCYNRRCVPHGKLCDGTNDCGDSSDELDCKVSTCSTVEF 2596
Query: 644 RC 649
RC
Sbjct: 2597 RC 2598
Score = 43.9 bits (102), Expect = 5e-04
Identities = 20/46 (43%), Positives = 27/46 (58%)
Frame = +2
Query: 509 CTAGSRLCRNGECINSAKFCDGKRDCADGSDEDQEFCRLCDPLSKR 646
C + +C+NG CI S CD + DC DGSDE C + + LSK+
Sbjct: 2891 CNSSFFMCKNGRCIPSDGLCDIRDDCGDGSDETN--CHINECLSKK 2934
Score = 43.5 bits (101), Expect = 7e-04
Identities = 20/62 (32%), Positives = 34/62 (54%), Gaps = 12/62 (19%)
Frame = +2
Query: 503 PICTAGSRLCRNGECINSAKFCDGKRDCADGSD---------EDQEFCR---LCDPLSKR 646
P+C++ +C +G C++++ C+G+ DC DGSD EDQ C+ C P+
Sbjct: 3592 PVCSSSEYMCASGGCLSASLKCNGEPDCVDGSDEMDCVIECKEDQFQCKNKAYCIPIRWL 3651
Query: 647 CE 652
C+
Sbjct: 3652 CD 3653
Score = 39.7 bits (91), Expect = 0.010
Identities = 20/41 (48%), Positives = 23/41 (56%), Gaps = 1/41 (2%)
Frame = +2
Query: 530 CRN-GECINSAKFCDGKRDCADGSDEDQEFCRLCDPLSKRC 649
CR+ G CIN+A CDG DC D SDE+ LC P C
Sbjct: 1103 CRSTGRCINNAWVCDGDVDCEDQSDEEDCDSFLCGPPKYPC 1143
Score = 38.9 bits (89), Expect = 0.017
Identities = 16/40 (40%), Positives = 23/40 (57%)
Frame = +3
Query: 687 IKHTGACDGEDDCGNGFDESRCSGNVRECGGLTYQCSDGT 806
+ H CDG +DCG+ DE C V C + ++C+DGT
Sbjct: 2565 VPHGKLCDGTNDCGDSSDELDC--KVSTCSTVEFRCADGT 2602
Score = 38.9 bits (89), Expect = 0.017
Identities = 24/67 (35%), Positives = 29/67 (43%), Gaps = 13/67 (19%)
Frame = +2
Query: 509 CTAGSRLCRNGECINSAKFCDGKRDCADGSDE---DQEFC----------RLCDPLSKRC 649
C G C G C A CDG+ DC D SDE D C + C P++ RC
Sbjct: 3357 CQPGRFQCGTGLCALPAFICDGENDCGDNSDELNCDTHVCLAGQFKCTKNKKCIPVNLRC 3416
Query: 650 ETHNGQN 670
NGQ+
Sbjct: 3417 ---NGQD 3420
Score = 38.5 bits (88), Expect = 0.022
Identities = 21/48 (43%), Positives = 25/48 (52%), Gaps = 3/48 (6%)
Frame = +2
Query: 509 CTAGSRLCR-NGECINSAKFCDGKRDCADGSDED--QEFCRLCDPLSK 643
C CR +G CI CDG++DC DGSDE RLCD +K
Sbjct: 1053 CIGNEFQCRPDGNCIPDLWRCDGEKDCEDGSDEKGCNGTIRLCDHKTK 1100
Score = 38.5 bits (88), Expect = 0.022
Identities = 24/68 (35%), Positives = 27/68 (39%), Gaps = 2/68 (2%)
Frame = +2
Query: 437 DNGTRFTCRKGRSSADVIVLVDPICTAGSRLCRNGECINSAKFCDGKRDCADGSDEDQEF 616
D TC +G S IC LC N C CDG+ DC D SDE +
Sbjct: 3660 DGSDEETCGRGGS----------ICRDDEFLCNNSLCKLHFWVCDGEDDCGDNSDEAPDM 3709
Query: 617 C--RLCDP 634
C LC P
Sbjct: 3710 CVKFLCPP 3717
Score = 37.7 bits (86), Expect = 0.037
Identities = 17/47 (36%), Positives = 23/47 (48%)
Frame = +2
Query: 545 CINSAKFCDGKRDCADGSDEDQEFCRLCDPLSKRCETHNGQNPTNNI 685
C+ K C+G++DC DGSDE + C C + C H P I
Sbjct: 1150 CLQPEKLCNGRKDCPDGSDEG-DLCDECSLNNGGCSNHCSVVPGRGI 1195
Score = 37.7 bits (86), Expect = 0.037
Identities = 23/62 (37%), Positives = 29/62 (46%), Gaps = 1/62 (1%)
Frame = +2
Query: 509 CTAGSRLCRNGECINSAKFCDGKRDCADGSDED-QEFCRLCDPLSKRCETHNGQNPTNNI 685
C + +C N CI CD DC DGSDE Q R C P RC +G+ N +
Sbjct: 2805 CDENAFMCHNKVCIPKQFVCDHDDDCGDGSDEFLQCGYRQCGPEEFRCA--DGRCLVNTL 2862
Query: 686 YQ 691
+Q
Sbjct: 2863 WQ 2864
Score = 37.4 bits (85), Expect = 0.049
Identities = 20/47 (42%), Positives = 26/47 (55%), Gaps = 2/47 (4%)
Frame = +2
Query: 509 CTAGSRLCRNGECINSAKFCDGKRDCADGSDE--DQEFCRLCDPLSK 643
C A C NG CI +A CD + DC D +DE EF C+PL++
Sbjct: 927 CQADQFSCGNGRCIPTAWLCDREDDCGDQTDEVASCEF-PTCEPLTQ 972
Score = 37.4 bits (85), Expect = 0.049
Identities = 16/33 (48%), Positives = 22/33 (66%)
Frame = +3
Query: 705 CDGEDDCGNGFDESRCSGNVRECGGLTYQCSDG 803
CD +DDCG+G DE G R+CG ++C+DG
Sbjct: 2824 CDHDDDCGDGSDEFLQCG-YRQCGPEEFRCADG 2855
Score = 37.4 bits (85), Expect = 0.049
Identities = 21/52 (40%), Positives = 22/52 (42%)
Frame = +2
Query: 545 CINSAKFCDGKRDCADGSDEDQEFCRLCDPLSKRCETHNGQNPTNNIYQAHW 700
CI+ CD DCAD SDE CD K C H Q NN HW
Sbjct: 3449 CISKLWVCDEDPDCADASDEAN-----CD--KKTCGPHEFQCKNNNCIPDHW 3493
Score = 36.6 bits (83), Expect = 0.083
Identities = 15/49 (30%), Positives = 19/49 (38%)
Frame = +2
Query: 473 SSADVIVLVDPICTAGSRLCRNGECINSAKFCDGKRDCADGSDEDQEFC 619
S D + + C C+N CI CDG DC DE + C
Sbjct: 874 SDEDSVTCFNHSCPDDQFKCQNNRCIPKRWLCDGANDCGSNEDESNQTC 922
Score = 36.6 bits (83), Expect = 0.083
Identities = 16/49 (32%), Positives = 24/49 (48%)
Frame = +2
Query: 509 CTAGSRLCRNGECINSAKFCDGKRDCADGSDEDQEFCRLCDPLSKRCET 655
C+ C NG+C+++ CDG DC G DE + C+P C +
Sbjct: 3553 CSKDQFQCSNGQCLSAKWKCDGHEDCKYGEDE-----KNCEPAFPVCSS 3596
Score = 36.2 bits (82), Expect = 0.11
Identities = 13/23 (56%), Positives = 16/23 (69%)
Frame = +3
Query: 705 CDGEDDCGNGFDESRCSGNVREC 773
CDGE DC +G DE C+G +R C
Sbjct: 1073 CDGEKDCEDGSDEKGCNGTIRLC 1095
Score = 35.4 bits (80), Expect = 0.19
Identities = 15/39 (38%), Positives = 21/39 (53%), Gaps = 1/39 (2%)
Frame = +2
Query: 506 ICTAGSRLCRNG-ECINSAKFCDGKRDCADGSDEDQEFC 619
+C G LC + C++ + CDG DC D SDE + C
Sbjct: 31 LCDPGEFLCHDHVTCVSQSWLCDGDPDCPDQSDESLDTC 69
Score = 35.4 bits (80), Expect = 0.19
Identities = 19/58 (32%), Positives = 24/58 (41%), Gaps = 14/58 (24%)
Frame = +2
Query: 530 CRNGECINSAKFCDGKRDCADGSDEDQEFC--------------RLCDPLSKRCETHN 661
C NG+C++ CDG C D SDE +C R C P K C+ N
Sbjct: 2518 CGNGDCVDYVLTCDGIPHCKDKSDEKLLYCENRSCRSGFKPCYNRRCVPHGKLCDGTN 2575
Score = 35.4 bits (80), Expect = 0.19
Identities = 13/25 (52%), Positives = 17/25 (68%)
Frame = +2
Query: 530 CRNGECINSAKFCDGKRDCADGSDE 604
C +G CI + CDG++DC DG DE
Sbjct: 2689 CPSGRCILNTWVCDGQKDCEDGLDE 2713
Score = 35.4 bits (80), Expect = 0.19
Identities = 19/50 (38%), Positives = 23/50 (46%), Gaps = 1/50 (2%)
Frame = +2
Query: 509 CTAGSRLCRNGECINSAKFCDGKRDCADGSDEDQEFCRL-CDPLSKRCET 655
CTA C+ +CI CD DC DGSDE + C P +C T
Sbjct: 3317 CTASQFRCKTDKCIPFWWKCDTVDDCGDGSDEPDDCPEFKCQPGRFQCGT 3366
Score = 35.4 bits (80), Expect = 0.19
Identities = 16/37 (43%), Positives = 20/37 (54%), Gaps = 3/37 (8%)
Frame = +2
Query: 530 CRNGECINSAKFCDGKRDCADGSDEDQ---EFCRLCD 631
C+N CI CD + DC+D SDED + C L D
Sbjct: 3483 CKNNNCIPDHWRCDNQNDCSDNSDEDNCKPQTCTLKD 3519
Score = 35.0 bits (79), Expect = 0.24
Identities = 17/43 (39%), Positives = 22/43 (51%), Gaps = 5/43 (11%)
Frame = +3
Query: 687 IKHTGACDGEDDCGNGFDESRCSGNVREC-----GGLTYQCSD 800
I G CD DDCG+G DE+ C ++ EC G + C D
Sbjct: 2904 IPSDGLCDIRDDCGDGSDETNC--HINECLSKKISGCSQDCQD 2944
Score = 35.0 bits (79), Expect = 0.24
Identities = 22/55 (40%), Positives = 24/55 (43%)
Frame = +2
Query: 509 CTAGSRLCRNGECINSAKFCDGKRDCADGSDEDQEFCRLCDPLSKRCETHNGQNP 673
C C N CI CD DC DGSDE + C L P+ CE N NP
Sbjct: 3762 CKKDEFTCSNRNCIPMELQCDSLDDCGDGSDE--QGC-LKTPIEHTCE--NNGNP 3811
Score = 34.7 bits (78), Expect = 0.32
Identities = 14/40 (35%), Positives = 18/40 (45%)
Frame = +2
Query: 500 DPICTAGSRLCRNGECINSAKFCDGKRDCADGSDEDQEFC 619
D C+ C +CI+ CDG+ DC D DE C
Sbjct: 2717 DSSCSWNQFACSVKKCISKHWICDGEDDCGDSLDESDSIC 2756
Score = 34.7 bits (78), Expect = 0.32
Identities = 15/33 (45%), Positives = 18/33 (54%)
Frame = +3
Query: 705 CDGEDDCGNGFDESRCSGNVRECGGLTYQCSDG 803
CDGE DC +G DE C C +QCS+G
Sbjct: 3534 CDGEFDCADGSDEKNCE---TSCSKDQFQCSNG 3563
Score = 34.3 bits (77), Expect = 0.41
Identities = 15/33 (45%), Positives = 18/33 (54%), Gaps = 1/33 (3%)
Frame = +2
Query: 509 CTAGSRLCRNGE-CINSAKFCDGKRDCADGSDE 604
C A C+ C+ CDG+RDC DGSDE
Sbjct: 2761 CAADMFSCQGSHACVPQHWLCDGERDCPDGSDE 2793
Score = 34.3 bits (77), Expect = 0.41
Identities = 13/33 (39%), Positives = 15/33 (45%)
Frame = +3
Query: 705 CDGEDDCGNGFDESRCSGNVRECGGLTYQCSDG 803
CDG +DC G DE C C Y C+ G
Sbjct: 3572 CDGHEDCKYGEDEKNCEPAFPVCSSSEYMCASG 3604
Score = 33.5 bits (75), Expect = 0.71
Identities = 13/33 (39%), Positives = 18/33 (54%)
Frame = +3
Query: 705 CDGEDDCGNGFDESRCSGNVRECGGLTYQCSDG 803
CDG +DCG+ DES + R C + C +G
Sbjct: 905 CDGANDCGSNEDESNQTCTARTCQADQFSCGNG 937
Score = 33.5 bits (75), Expect = 0.71
Identities = 18/51 (35%), Positives = 25/51 (49%), Gaps = 1/51 (1%)
Frame = +2
Query: 506 ICTAGSRLC-RNGECINSAKFCDGKRDCADGSDEDQEFCRLCDPLSKRCET 655
+C AG C +N +CI C+G+ DC D DE C P +C+T
Sbjct: 3395 VCLAGQFKCTKNKKCIPVNLRCNGQDDCGDEEDEKDCPENSCSPDYFQCKT 3445
Score = 33.1 bits (74), Expect = 0.92
Identities = 12/26 (46%), Positives = 17/26 (65%)
Frame = +2
Query: 527 LCRNGECINSAKFCDGKRDCADGSDE 604
+C++G CI++ CD DC D SDE
Sbjct: 974 ICKSGRCISNKWHCDTDDDCGDRSDE 999
Score = 33.1 bits (74), Expect = 0.92
Identities = 14/30 (46%), Positives = 15/30 (50%)
Frame = +2
Query: 530 CRNGECINSAKFCDGKRDCADGSDEDQEFC 619
C +G CI CDG DC D SDE C
Sbjct: 1013 CSSGRCIPGHWACDGDNDCGDFSDETHINC 1042
Score = 32.7 bits (73), Expect = 1.2
Identities = 13/30 (43%), Positives = 15/30 (50%)
Frame = +3
Query: 705 CDGEDDCGNGFDESRCSGNVRECGGLTYQC 794
CDGEDDCG+ DES C + C
Sbjct: 2739 CDGEDDCGDSLDESDSICGAVTCAADMFSC 2768
Score = 32.7 bits (73), Expect = 1.2
Identities = 20/55 (36%), Positives = 26/55 (47%), Gaps = 7/55 (12%)
Frame = +3
Query: 666 KIQPITFIKHTGAC-------DGEDDCGNGFDESRCSGNVRECGGLTYQCSDGTK 809
K QP F TG C DGE+DCG+ DE C +V C ++C+ K
Sbjct: 3356 KCQPGRFQCGTGLCALPAFICDGENDCGDNSDELNCDTHV--CLAGQFKCTKNKK 3408
Score = 32.0 bits (71), Expect = 2.1
Identities = 14/37 (37%), Positives = 19/37 (51%)
Frame = +3
Query: 687 IKHTGACDGEDDCGNGFDESRCSGNVRECGGLTYQCS 797
I +T CDG+ DC +G DE C + C + CS
Sbjct: 2695 ILNTWVCDGQKDCEDGLDELHCDSS---CSWNQFACS 2728
Score = 32.0 bits (71), Expect = 2.1
Identities = 18/51 (35%), Positives = 22/51 (43%), Gaps = 1/51 (1%)
Frame = +2
Query: 458 CRKGRSSADVIVLVDPICTAGSRLCRN-GECINSAKFCDGKRDCADGSDED 607
C G D ++ C C+N CI CDG DC DGSDE+
Sbjct: 3619 CVDGSDEMDCVIE----CKEDQFQCKNKAYCIPIRWLCDGIYDCVDGSDEE 3665
Score = 32.0 bits (71), Expect = 2.1
Identities = 13/27 (48%), Positives = 16/27 (59%), Gaps = 1/27 (3%)
Frame = +2
Query: 530 CRNGE-CINSAKFCDGKRDCADGSDED 607
CRN C+ K C+G DC D SDE+
Sbjct: 3723 CRNDRICLQLEKICNGINDCGDNSDEE 3749
Score = 31.6 bits (70), Expect = 2.7
Identities = 16/43 (37%), Positives = 22/43 (51%), Gaps = 1/43 (2%)
Frame = +2
Query: 530 CRNGEC-INSAKFCDGKRDCADGSDEDQEFCRLCDPLSKRCET 655
C +G C +N+ CDG DC D SDE P++ RC +
Sbjct: 2852 CADGRCLVNTLWQCDGDFDCPDSSDE--------APINPRCRS 2886
Score = 30.8 bits (68), Expect = 4.6
Identities = 15/41 (36%), Positives = 20/41 (48%)
Frame = +2
Query: 545 CINSAKFCDGKRDCADGSDEDQEFCRLCDPLSKRCETHNGQ 667
C++ +K C+G DC DG DE C L C+ N Q
Sbjct: 90 CVHLSKLCNGVVDCPDGFDEGGH----CQELLPSCQQLNCQ 126
Score = 30.8 bits (68), Expect = 4.6
Identities = 11/18 (61%), Positives = 13/18 (72%)
Frame = +3
Query: 693 HTGACDGEDDCGNGFDES 746
H CDGEDDCG+ DE+
Sbjct: 3689 HFWVCDGEDDCGDNSDEA 3706
Score = 30.4 bits (67), Expect = 6.0
Identities = 14/33 (42%), Positives = 18/33 (54%)
Frame = +3
Query: 705 CDGEDDCGNGFDESRCSGNVRECGGLTYQCSDG 803
CD +DDCG+ DE C V C ++CS G
Sbjct: 987 CDTDDDCGDRSDEVGC---VHSCLDDQFRCSSG 1016
Score = 30.4 bits (67), Expect = 6.0
Identities = 12/32 (37%), Positives = 17/32 (53%)
Frame = +2
Query: 509 CTAGSRLCRNGECINSAKFCDGKRDCADGSDE 604
C+ C +G CI + C+ DC+D SDE
Sbjct: 2591 CSTVEFRCADGTCIPRSARCNQNMDCSDASDE 2622
Score = 30.4 bits (67), Expect = 6.0
Identities = 13/30 (43%), Positives = 17/30 (56%)
Frame = +3
Query: 705 CDGEDDCGNGFDESRCSGNVRECGGLTYQC 794
C+G+DDCG+ DE C N C +QC
Sbjct: 3416 CNGQDDCGDEEDEKDCPEN--SCSPDYFQC 3443
Score = 30.4 bits (67), Expect = 6.0
Identities = 13/36 (36%), Positives = 20/36 (55%), Gaps = 4/36 (11%)
Frame = +3
Query: 705 CDGEDDCGNGFDESRCSGNV----RECGGLTYQCSD 800
C+G +DCG+ DE CSG + + C + CS+
Sbjct: 3736 CNGINDCGDNSDEEHCSGKLSLKSKPCKKDEFTCSN 3771
Score = 30.0 bits (66), Expect = 7.8
Identities = 14/40 (35%), Positives = 20/40 (50%)
Frame = +3
Query: 687 IKHTGACDGEDDCGNGFDESRCSGNVRECGGLTYQCSDGT 806
I + CDG+ DC + DE C + CG Y C++ T
Sbjct: 1110 INNAWVCDGDVDCEDQSDEEDCDSFL--CGPPKYPCANDT 1147
>sp|Q07954|LRP1_HUMAN Low-density lipoprotein receptor-related protein 1 precursor (LRP)
(Alpha-2-macroglobulin receptor) (A2MR) (Apolipoprotein E
receptor) (APOER) (CD91)
Length = 4544
Score = 48.5 bits (114), Expect = 2e-05
Identities = 31/91 (34%), Positives = 43/91 (47%), Gaps = 5/91 (5%)
Frame = +2
Query: 431 TNDNGTRFTCRKGRSSADVIVL--VDPICTAGSRL-CRNGECINSAKFCDGKRDCADGSD 601
T+ +CR GR D + V+ C A C NGECIN + CDG C D SD
Sbjct: 2496 THQGHVNCSCRGGRILQDDLTCRAVNSSCRAQDEFECANGECINFSLTCDGVPHCKDKSD 2555
Query: 602 EDQEFC--RLCDPLSKRCETHNGQNPTNNIY 688
E +C R C ++C NG+ +N ++
Sbjct: 2556 EKPSYCNSRRCKKTFRQCS--NGRCVSNMLW 2584
Score = 45.4 bits (106), Expect = 2e-04
Identities = 20/43 (46%), Positives = 27/43 (62%), Gaps = 2/43 (4%)
Frame = +2
Query: 536 NGECINSAKFCDGKRDCADGSDEDQEFC--RLCDPLSKRCETH 658
+G CI + CDG+ DC DGSDE +E C R C+P RC+ +
Sbjct: 3504 SGRCIPARWKCDGEDDCGDGSDEPKEECDERTCEPYQFRCKNN 3546
Score = 44.7 bits (104), Expect = 3e-04
Identities = 25/59 (42%), Positives = 28/59 (47%), Gaps = 11/59 (18%)
Frame = +2
Query: 509 CTAGSRLCRNGECINSAKFCDGKRDCADGSDE---------DQEFCRL--CDPLSKRCE 652
C+ C NG CI CDG DCADGSDE DQ C+ C PL RC+
Sbjct: 3575 CSESEFSCANGRCIAGRWKCDGDHDCADGSDEKDCTPRCDMDQFQCKSGHCIPLRWRCD 3633
Score = 43.1 bits (100), Expect = 9e-04
Identities = 23/54 (42%), Positives = 27/54 (50%), Gaps = 2/54 (3%)
Frame = +2
Query: 494 LVDPICTAGSRLCRNGECINSAKFCDGKRDCADGSDEDQEFCR--LCDPLSKRC 649
L + C +C+N +CI CD RDCADGSDE E C C P RC
Sbjct: 2813 LYNSTCDDREFMCQNRQCIPKHFVCDHDRDCADGSDESPE-CEYPTCGPSEFRC 2865
Score = 43.1 bits (100), Expect = 9e-04
Identities = 20/51 (39%), Positives = 22/51 (43%)
Frame = +2
Query: 509 CTAGSRLCRNGECINSAKFCDGKRDCADGSDEDQEFCRLCDPLSKRCETHN 661
C G C G C N A CDG DC D SDE +C P +C N
Sbjct: 3374 CRPGQFQCSTGICTNPAFICDGDNDCQDNSDEANCDIHVCLPSQFKCTNTN 3424
Score = 41.2 bits (95), Expect = 0.003
Identities = 20/54 (37%), Positives = 22/54 (40%), Gaps = 2/54 (3%)
Frame = +2
Query: 503 PICTAGSRLCRNGECINSAKFCDGKRDCADGSDEDQEFC--RLCDPLSKRCETH 658
P C G C N CI CDG DC D SDE C C +CE +
Sbjct: 852 PQCQPGEFACANSRCIQERWKCDGDNDCLDNSDEAPALCHQHTCPSDRFKCENN 905
Score = 40.8 bits (94), Expect = 0.004
Identities = 21/53 (39%), Positives = 26/53 (49%), Gaps = 6/53 (11%)
Frame = +2
Query: 509 CTAGSRLCRNG-ECINSAKFCDGKRDCADGSDEDQEFC-----RLCDPLSKRC 649
C+ CR+ CI+ CDG+RDC DGSDE E C + C P C
Sbjct: 27 CSPKQFACRDQITCISKGWRCDGERDCPDGSDEAPEICPQSKAQRCQPNEHNC 79
Score = 40.4 bits (93), Expect = 0.006
Identities = 15/32 (46%), Positives = 20/32 (62%)
Frame = +2
Query: 509 CTAGSRLCRNGECINSAKFCDGKRDCADGSDE 604
C R C NG C+++ +C+G DC DGSDE
Sbjct: 2566 CKKTFRQCSNGRCVSNMLWCNGADDCGDGSDE 2597
Score = 40.0 bits (92), Expect = 0.008
Identities = 20/49 (40%), Positives = 24/49 (48%), Gaps = 2/49 (4%)
Frame = +2
Query: 509 CTAGSRLCRNGECINSAKFCDGKRDCADGSDEDQEFC--RLCDPLSKRC 649
C+ C+N CI+ CDG DC DGSDE C + C P S C
Sbjct: 2734 CSEAQFECQNHRCISKQWLCDGSDDCGDGSDE-AAHCEGKTCGPSSFSC 2781
Score = 39.7 bits (91), Expect = 0.010
Identities = 19/47 (40%), Positives = 28/47 (59%), Gaps = 1/47 (2%)
Frame = +2
Query: 509 CTAGSR-LCRNGECINSAKFCDGKRDCADGSDEDQEFCRLCDPLSKR 646
C A S+ LC +G C+ A C+G+ DC D SDE C + + LS++
Sbjct: 2904 CNASSQFLCSSGRCVAEALLCNGQDDCGDSSDE--RGCHINECLSRK 2948
Score = 39.3 bits (90), Expect = 0.013
Identities = 22/54 (40%), Positives = 26/54 (48%), Gaps = 2/54 (3%)
Frame = +2
Query: 509 CTAGSRLCRNGE--CINSAKFCDGKRDCADGSDEDQEFCRLCDPLSKRCETHNG 664
C S C N C+ K CDG DC DGSDE + LCD +C +NG
Sbjct: 1145 CRPPSHPCANNTSVCLPPDKLCDGNDDCGDGSDEGE----LCD----QCSLNNG 1190
Score = 39.3 bits (90), Expect = 0.013
Identities = 25/76 (32%), Positives = 32/76 (42%), Gaps = 16/76 (21%)
Frame = +2
Query: 503 PICTAGSRLCRNGECINSAKFCDGKRDCADGSDE------------DQEFCR--LCDPLS 640
P C C++G CI CD DC DGSDE D+ C LC PL+
Sbjct: 3611 PRCDMDQFQCKSGHCIPLRWRCDADADCMDGSDEEACGTGVRTCPLDEFQCNNTLCKPLA 3670
Query: 641 KRCETHN--GQNPTNN 682
+C+ + G N N
Sbjct: 3671 WKCDGEDDCGDNSDEN 3686
Score = 38.5 bits (88), Expect = 0.022
Identities = 17/34 (50%), Positives = 21/34 (61%)
Frame = +3
Query: 705 CDGEDDCGNGFDESRCSGNVRECGGLTYQCSDGT 806
C+G DDCG+G DE C N CG ++C DGT
Sbjct: 2585 CNGADDCGDGSDEIPC--NKTACGVGEFRCRDGT 2616
Score = 38.5 bits (88), Expect = 0.022
Identities = 21/56 (37%), Positives = 27/56 (48%), Gaps = 1/56 (1%)
Frame = +2
Query: 509 CTAGSRLCRNGECINSAKFCDGKRDCADGSDEDQEFCRL-CDPLSKRCETHNGQNP 673
CTA +C+N +CI CD + DC D SDE + C P +C T NP
Sbjct: 3334 CTASQFVCKNDKCIPFWWKCDTEDDCGDHSDEPPDCPEFKCRPGQFQCSTGICTNP 3389
Score = 37.7 bits (86), Expect = 0.037
Identities = 17/49 (34%), Positives = 20/49 (40%), Gaps = 2/49 (4%)
Frame = +2
Query: 509 CTAGSRLCRNGECINSAKFCDGKRDCADGSDEDQEFC--RLCDPLSKRC 649
C + C N CI + CDG DC + DE C R C P C
Sbjct: 895 CPSDRFKCENNRCIPNRWLCDGDNDCGNSEDESNATCSARTCPPNQFSC 943
Score = 37.7 bits (86), Expect = 0.037
Identities = 14/33 (42%), Positives = 20/33 (60%)
Frame = +3
Query: 705 CDGEDDCGNGFDESRCSGNVRECGGLTYQCSDG 803
CDG++DCGN DES + + R C + C+ G
Sbjct: 914 CDGDNDCGNSEDESNATCSARTCPPNQFSCASG 946
Score = 37.7 bits (86), Expect = 0.037
Identities = 16/35 (45%), Positives = 21/35 (60%), Gaps = 1/35 (2%)
Frame = +2
Query: 503 PICTAGSRLCRNGECINSAKF-CDGKRDCADGSDE 604
P C C NG C++S ++ CDG+ DC D SDE
Sbjct: 2856 PTCGPSEFRCANGRCLSSRQWECDGENDCHDQSDE 2890
Score = 37.7 bits (86), Expect = 0.037
Identities = 20/44 (45%), Positives = 26/44 (59%)
Frame = +2
Query: 527 LCRNGECINSAKFCDGKRDCADGSDEDQEFCRLCDPLSKRCETH 658
LCRN C++S+ C+ DC DGSDE E C + DP C T+
Sbjct: 3748 LCRNQRCLSSSLRCNMFDDCGDGSDE--EDCSI-DPKLTSCATN 3788
Score = 37.0 bits (84), Expect = 0.064
Identities = 21/60 (35%), Positives = 27/60 (45%)
Frame = +2
Query: 470 RSSADVIVLVDPICTAGSRLCRNGECINSAKFCDGKRDCADGSDEDQEFCRLCDPLSKRC 649
+S V + DP G + + CI+ A CDG DC D SDE+ C P S C
Sbjct: 1095 KSCEGVTHVCDPSVKFGCK--DSARCISKAWVCDGDNDCEDNSDEENCESLACRPPSHPC 1152
Score = 36.6 bits (83), Expect = 0.083
Identities = 23/69 (33%), Positives = 28/69 (40%), Gaps = 21/69 (30%)
Frame = +2
Query: 509 CTAGSRLCRNGECINSAKFCDGKRDCADGSDE------------------DQEFCR---L 625
C++ C +G CI CDG DC D SDE D+ CR L
Sbjct: 1015 CSSTQFKCNSGRCIPEHWTCDGDNDCGDYSDETHANCTNQATRPPGGCHTDEFQCRLDGL 1074
Query: 626 CDPLSKRCE 652
C PL RC+
Sbjct: 1075 CIPLRWRCD 1083
Score = 36.6 bits (83), Expect = 0.083
Identities = 14/32 (43%), Positives = 20/32 (62%)
Frame = +3
Query: 705 CDGEDDCGNGFDESRCSGNVRECGGLTYQCSD 800
CDGEDDCG+G DE + + R C ++C +
Sbjct: 3514 CDGEDDCGDGSDEPKEECDERTCEPYQFRCKN 3545
Score = 35.4 bits (80), Expect = 0.19
Identities = 14/25 (56%), Positives = 14/25 (56%)
Frame = +2
Query: 530 CRNGECINSAKFCDGKRDCADGSDE 604
C NG CIN CD DC D SDE
Sbjct: 984 CNNGRCININWRCDNDNDCGDNSDE 1008
Score = 35.4 bits (80), Expect = 0.19
Identities = 15/31 (48%), Positives = 20/31 (64%), Gaps = 1/31 (3%)
Frame = +3
Query: 705 CDGEDDCGNGFDE-SRCSGNVRECGGLTYQC 794
CDG DDCG+G DE + C G + CG ++ C
Sbjct: 2753 CDGSDDCGDGSDEAAHCEG--KTCGPSSFSC 2781
Score = 35.4 bits (80), Expect = 0.19
Identities = 18/44 (40%), Positives = 21/44 (47%), Gaps = 2/44 (4%)
Frame = +2
Query: 509 CTAGSRLCRNGECINSAKFCDGKRDCADGSDEDQEFCR--LCDP 634
C C N C A CDG+ DC D SDE+ E C +C P
Sbjct: 3654 CPLDEFQCNNTLCKPLAWKCDGEDDCGDNSDENPEECARFVCPP 3697
Score = 34.3 bits (77), Expect = 0.41
Identities = 14/32 (43%), Positives = 18/32 (56%)
Frame = +2
Query: 509 CTAGSRLCRNGECINSAKFCDGKRDCADGSDE 604
C G CR+G CI ++ C+ DC D SDE
Sbjct: 2605 CGVGEFRCRDGTCIGNSSRCNQFVDCEDASDE 2636
Score = 33.9 bits (76), Expect = 0.54
Identities = 15/32 (46%), Positives = 18/32 (56%), Gaps = 1/32 (3%)
Frame = +3
Query: 705 CDGEDDCGNGFDESR-CSGNVRECGGLTYQCS 797
CDG DDCG+G DE C GG ++ CS
Sbjct: 1166 CDGNDDCGDGSDEGELCDQCSLNNGGCSHNCS 1197
Score = 33.9 bits (76), Expect = 0.54
Identities = 17/53 (32%), Positives = 23/53 (43%), Gaps = 1/53 (1%)
Frame = +2
Query: 503 PICTAGSRLCRNGECINSAKFCDGKRDCADGSDEDQEFC-RLCDPLSKRCETH 658
P C C +G CI + CD + DC G ED+ C + C C+ H
Sbjct: 2694 PRCPLNYFACPSGRCIPMSWTCDKEDDCEHG--EDETHCNKFCSEAQFECQNH 2744
Score = 33.1 bits (74), Expect = 0.92
Identities = 12/33 (36%), Positives = 19/33 (57%)
Frame = +3
Query: 705 CDGEDDCGNGFDESRCSGNVRECGGLTYQCSDG 803
CD ++DCG+ DE+ CS C ++C+ G
Sbjct: 996 CDNDNDCGDNSDEAGCS---HSCSSTQFKCNSG 1025
Score = 33.1 bits (74), Expect = 0.92
Identities = 13/32 (40%), Positives = 18/32 (56%)
Frame = +3
Query: 705 CDGEDDCGNGFDESRCSGNVRECGGLTYQCSD 800
CD + DC +G DE C VR C +QC++
Sbjct: 3632 CDADADCMDGSDEEACGTGVRTCPLDEFQCNN 3663
Score = 32.7 bits (73), Expect = 1.2
Identities = 26/86 (30%), Positives = 37/86 (43%), Gaps = 3/86 (3%)
Frame = +2
Query: 356 ASDSQRTTVEKLEAGKVQLTYRAVTTNDNGTRFTCRKGRSSADVIVLVDPI--CTAGSRL 529
A D+ +T K A + Q+T + +G R C G A I C
Sbjct: 20 AIDAPKTCSPKQFACRDQITCISKGWRCDGER-DCPDGSDEAPEICPQSKAQRCQPNEHN 78
Query: 530 CRNGE-CINSAKFCDGKRDCADGSDE 604
C E C+ ++ C+G +DC DGSDE
Sbjct: 79 CLGTELCVPMSRLCNGVQDCMDGSDE 104
Score = 32.7 bits (73), Expect = 1.2
Identities = 14/40 (35%), Positives = 17/40 (42%)
Frame = +2
Query: 530 CRNGECINSAKFCDGKRDCADGSDEDQEFCRLCDPLSKRC 649
C+N C+ CD DC D SDE+ R C C
Sbjct: 3543 CKNNRCVPGRWQCDYDNDCGDNSDEESCTPRPCSESEFSC 3582
Score = 32.0 bits (71), Expect = 2.1
Identities = 19/48 (39%), Positives = 22/48 (45%), Gaps = 3/48 (6%)
Frame = +2
Query: 509 CTAGSRLCR-NGECINSAKFCDGKRDCADGSDED--QEFCRLCDPLSK 643
C CR +G CI CDG DC D SDE + +CDP K
Sbjct: 1062 CHTDEFQCRLDGLCIPLRWRCDGDTDCMDSSDEKSCEGVTHVCDPSVK 1109
Score = 32.0 bits (71), Expect = 2.1
Identities = 11/20 (55%), Positives = 14/20 (70%)
Frame = +2
Query: 545 CINSAKFCDGKRDCADGSDE 604
C+ CDG +DCADG+DE
Sbjct: 2787 CVPERWLCDGDKDCADGADE 2806
Score = 32.0 bits (71), Expect = 2.1
Identities = 14/35 (40%), Positives = 19/35 (54%), Gaps = 3/35 (8%)
Frame = +3
Query: 705 CDGEDDCGNGFDESRCSGN---VRECGGLTYQCSD 800
C+G+DDCG+ DE C N R+ G + C D
Sbjct: 2924 CNGQDDCGDSSDERGCHINECLSRKLSGCSQDCED 2958
Score = 31.6 bits (70), Expect = 2.7
Identities = 20/55 (36%), Positives = 24/55 (43%), Gaps = 21/55 (38%)
Frame = +3
Query: 705 CDGEDDCGNGFDES---------------RCSGN------VRECGGLTYQCSDGT 806
CDGEDDCG+ DE+ RC + R+C G T C DGT
Sbjct: 3673 CDGEDDCGDNSDENPEECARFVCPPNRPFRCKNDRVCLWIGRQCDG-TDNCGDGT 3726
Score = 30.8 bits (68), Expect = 4.6
Identities = 12/32 (37%), Positives = 19/32 (59%)
Frame = +3
Query: 705 CDGEDDCGNGFDESRCSGNVRECGGLTYQCSD 800
CD EDDC +G DE+ C+ + C ++C +
Sbjct: 2715 CDKEDDCEHGEDETHCN---KFCSEAQFECQN 2743
Score = 30.8 bits (68), Expect = 4.6
Identities = 12/33 (36%), Positives = 19/33 (57%)
Frame = +3
Query: 705 CDGEDDCGNGFDESRCSGNVRECGGLTYQCSDG 803
CD ++DCG+ DE C+ R C + C++G
Sbjct: 3555 CDYDNDCGDNSDEESCT--PRPCSESEFSCANG 3585
Score = 30.8 bits (68), Expect = 4.6
Identities = 13/33 (39%), Positives = 17/33 (51%)
Frame = +3
Query: 705 CDGEDDCGNGFDESRCSGNVRECGGLTYQCSDG 803
CDG+ DC +G DE C+ C +QC G
Sbjct: 3594 CDGDHDCADGSDEKDCT---PRCDMDQFQCKSG 3623
Score = 30.4 bits (67), Expect = 6.0
Identities = 12/36 (33%), Positives = 17/36 (47%), Gaps = 1/36 (2%)
Frame = +3
Query: 705 CDGEDDCGNGFDESRCSGNVRECG-GLTYQCSDGTK 809
CDG+ DC + DE C G C + + C D +
Sbjct: 1082 CDGDTDCMDSSDEKSCEGVTHVCDPSVKFGCKDSAR 1117
Score = 30.0 bits (66), Expect = 7.8
Identities = 13/31 (41%), Positives = 18/31 (58%)
Frame = +3
Query: 705 CDGEDDCGNGFDESRCSGNVRECGGLTYQCS 797
C+G+D+CG+G DE C C +QCS
Sbjct: 3433 CNGQDNCGDGEDERDCPEVT--CAPNQFQCS 3461
Database: Non-redundant SwissProt sequences
Posted date: Dec 6, 2005 7:40 AM
Number of letters in database: 68,354,980
Number of sequences in database: 184,735
Database: swissprot.01
Posted date: Dec 6, 2005 8:18 AM
Number of letters in database: 66,202,850
Number of sequences in database: 184,431
Lambda K H
0.318 0.134 0.401
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 91,894,626
Number of Sequences: 369166
Number of extensions: 1861468
Number of successful extensions: 6665
Number of sequences better than 10.0: 10
Number of HSP's better than 10.0 without gapping: 4969
Number of HSP's successfully gapped in prelim test: 0
Number of HSP's that attempted gapping in prelim test: 0
Number of HSP's gapped (non-prelim): 6614
length of database: 68,354,980
effective HSP length: 109
effective length of database: 48,218,865
effective search space used: 7715018400
frameshift window, decay const: 40, 0.1
T: 12
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)