Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= Dr_sW_007_K21
(877 letters)
Database: Non-redundant SwissProt sequences
184,735 sequences; 68,354,980 total letters
Score E
Sequences producing significant alignments: (bits) Value
sp|O02485|YDJ1_CAEEL Hypothetical protein ZK1073.1 in chrom... 165 2e-40
sp|Q92597|NDRG1_HUMAN NDRG1 protein (N-myc downstream regul... 101 3e-21
sp|Q62433|NDRG1_MOUSE NDRG1 protein (N-myc downstream regul... 99 1e-20
sp|Q9UGV2|NDRG3_HUMAN NDRG3 protein 93 8e-19
sp|Q9QYF9|NDRG3_MOUSE NDRG3 protein (Ndr3 protein) 90 9e-18
sp|Q8BTG7|NDRG4_MOUSE NDRG4 protein 80 6e-15
sp|Q9ULP0|NDRG4_HUMAN NDRG4 protein (Brain development-rela... 79 1e-14
sp|Q9Z2L9|NDRG4_RAT NDRG4 protein (Brain development-relate... 77 8e-14
sp|O23969|SF21_HELAN Pollen-specific protein SF21 75 3e-13
sp|Q9QYG0|NDRG2_MOUSE NDRG2 protein (Ndr2 protein) 70 6e-12
>sp|O02485|YDJ1_CAEEL Hypothetical protein ZK1073.1 in chromosome X
Length = 325
Score = 165 bits (417), Expect = 2e-40
Identities = 96/281 (34%), Positives = 160/281 (56%), Gaps = 3/281 (1%)
Frame = +3
Query: 6 RGNKLF*RFTH-LGCNHYQYEEFLSNPKMAALSQKFVWIHVDLPGQGDGDEDLETNFPSM 182
RG K H +G NH + F+++P MA + +K +++HV +PGQ D D +FP++
Sbjct: 30 RGGKTIILTVHDIGTNHKSFVRFVNHPSMATVKEKAIFLHVCVPGQEDNSADFFGDFPTL 89
Query: 183 EDIALDLQELCEQMKLSNVLLFGEGAGANILARFAINNEHLVLGAILIHCVGSTASMIES 362
+ I DL + ++ ++ + + FGEG GANI+ RFA+ + + ++G +L+HC +TA +IE
Sbjct: 90 DGIGDDLSAVLDKFEVKSAIAFGEGVGANIICRFAMGHPNRIMGIVLVHCTSTTAGIIEY 149
Query: 363 LKDKVINWKLNSIGMNPTAESYLVLHRFGTQSVKFKNAETEVELKNVIESFKYNLKNSIN 542
K+KV+N +L + M+ A YL+ H+FG +S K+ + +E LK ++N
Sbjct: 150 CKEKVMNMRLENSIMSDGAWDYLLAHKFGGES---KSRQEYLE----------ELKATLN 196
Query: 543 PKNLYKFINTFITRRNLGERI-AKL-NVPTLFITGAAAIHCKNVHLLQETLLKTKQADQK 716
PKNL K++ F R +L I KL V L +TG+ A H T+ T ++ K
Sbjct: 197 PKNLSKYLVAFTKRTDLSSTIGTKLETVDALLVTGSKASHL-------HTVYTTHKSMNK 249
Query: 717 VKFELVQIDGVANVLTEAPEKVVVSLQYFLQGLGLVSNLRL 839
K L+ +D VA+V+ EAP+K+ SL +G G++S + +
Sbjct: 250 KKTTLLVVDNVADVMQEAPDKLARSLILLCKGCGVLSGVAI 290
>sp|Q92597|NDRG1_HUMAN NDRG1 protein (N-myc downstream regulated gene 1 protein)
(Differentiation-related gene 1 protein) (DRG1)
(Reducing agents and tunicamycin-responsive protein)
(RTP) (Nickel-specific induction protein Cap43) (Rit42)
Length = 394
Score = 101 bits (251), Expect = 3e-21
Identities = 75/278 (26%), Positives = 125/278 (44%), Gaps = 10/278 (3%)
Frame = +3
Query: 39 LGCNHYQ-YEEFLSNPKMAALSQKFVWIHVDLPGQGDGDEDLETNF--PSMEDIALDLQE 209
+G NH Y + M ++Q F HVD PGQ DG + PSM+ +A L
Sbjct: 65 IGMNHKTCYNPLFNYEDMQEITQHFAVCHVDAPGQQDGAASFPAGYMYPSMDQLAEMLPG 124
Query: 210 LCEQMKLSNVLLFGEGAGANILARFAINNEHLVLGAILIHCVGSTASMIESLKDKVINWK 389
+ +Q L +++ G GAGA IL RFA+NN +V G +LI+ ++ K+ W
Sbjct: 125 VLQQFGLKSIIGMGTGAGAYILTRFALNNPEMVEGLVLINVNPCAEGWMDWAASKISGW- 183
Query: 390 LNSIGMNPTAESYLVLHRFGTQSVKFKNAETEVELKNVIESFKYNLKNSINPKNLYKFIN 569
+V H FG + ++ N E V+ +++ ++ N +NP NL+ FIN
Sbjct: 184 ------TQALPDMVVSHLFGKEEMQ-SNVE-------VVHTYRQHIVNDMNPGNLHLFIN 229
Query: 570 TFITRRNL-------GERIAKLNVPTLFITGAAAIHCKNVHLLQETLLKTKQADQKVKFE 728
+ +RR+L G L P L + G ++ V L TK +
Sbjct: 230 AYNSRRDLEIERPMPGTHTVTLQCPALLVVGDSSPAVDAVVECNSKLDPTK----TTLLK 285
Query: 729 LVQIDGVANVLTEAPEKVVVSLQYFLQGLGLVSNLRLS 842
+ G+ + P K+ + +YF+QG+G + + ++
Sbjct: 286 MADCGGLPQI--SQPAKLAEAFKYFVQGMGYMPSASMT 321
>sp|Q62433|NDRG1_MOUSE NDRG1 protein (N-myc downstream regulated gene 1 protein) (Protein
Ndr1)
Length = 394
Score = 99.4 bits (246), Expect = 1e-20
Identities = 76/285 (26%), Positives = 127/285 (44%), Gaps = 17/285 (5%)
Frame = +3
Query: 39 LGCNHYQ-YEEFLSNPKMAALSQKFVWIHVDLPGQGDGDEDLETNF--PSMEDIALDLQE 209
+G NH Y ++ M ++Q F HVD PGQ DG + PSM+ +A L
Sbjct: 65 IGMNHKTCYNPLFNSEDMQEITQHFAVCHVDAPGQQDGAPSFPVGYMYPSMDQLAEMLPG 124
Query: 210 LCEQMKLSNVLLFGEGAGANILARFAINNEHLVLGAILIHCVGSTASMIESLKDKVINWK 389
+ Q L +V+ G GAGA IL RFA+NN +V G +L++ ++ K+ W
Sbjct: 125 VLHQFGLKSVIGMGTGAGAYILTRFALNNPEMVEGLVLMNVNPCAEGWMDWAASKISGW- 183
Query: 390 LNSIGMNPTAESYLVLHRFGTQSVKFKNAETEVELKNVIESFKYNLKNSINPKNLYKFIN 569
+V H FG + + N E V+ +++ ++ N +NP NL+ FI+
Sbjct: 184 ------TQALPDMVVSHLFGKEEI-HNNVE-------VVHTYRQHILNDMNPSNLHLFIS 229
Query: 570 TFITRRNL-------GERIAKLNVPTLFITG------AAAIHCKN-VHLLQETLLKTKQA 707
+ +RR+L G L P L + G A + C + + + TLLK
Sbjct: 230 AYNSRRDLEIERPMPGTHTVTLQCPALLVVGDNSPAVDAVVECNSKLDPTKTTLLK---- 285
Query: 708 DQKVKFELVQIDGVANVLTEAPEKVVVSLQYFLQGLGLVSNLRLS 842
+ G+ + P K+ + +YF+QG+G + + ++
Sbjct: 286 -------MADCGGLPQI--SQPAKLAEAFKYFVQGMGYMPSASMT 321
>sp|Q9UGV2|NDRG3_HUMAN NDRG3 protein
Length = 375
Score = 93.2 bits (230), Expect = 8e-19
Identities = 74/289 (25%), Positives = 135/289 (46%), Gaps = 21/289 (7%)
Frame = +3
Query: 39 LGCNHYQ-YEEFLSNPKMAALSQKFVWIHVDLPGQGDGDEDLETNF--PSMEDIALDLQE 209
+G NH + F + M ++Q F HVD PGQ +G T + P+M+++A L
Sbjct: 63 IGLNHKSCFNAFFNFEDMQEITQHFAVCHVDAPGQQEGAPSFPTGYQYPTMDELAEMLPP 122
Query: 210 LCEQMKLSNVLLFGEGAGANILARFAINNEHLVLGAILIHCVGSTASMIESLKDKVINWK 389
+ + L +++ G GAGA IL+RFA+N+ LV G +LI+ ++ I+W
Sbjct: 123 VLTHLSLKSIIGIGVGAGAYILSRFALNHPELVEGLVLIN--------VDPCAKGWIDWA 174
Query: 390 LNSI-GMNPTAESYLVLHRFGTQSVKFKNAETEVELKNVIESFKYNLKNSINPKNLYKFI 566
+ + G+ ++ H FG + E + L ++I++++ ++ IN NL F+
Sbjct: 175 ASKLSGLTTNVVDIILAHHFGQE-------ELQANL-DLIQTYRMHIAQDINQDNLQLFL 226
Query: 567 NTFITRRNL----------GERIAKLNVPTLFITG------AAAIHCKN-VHLLQETLLK 695
N++ RR+L + L TL + G A + C + ++ + TLLK
Sbjct: 227 NSYNGRRDLEIERPILGQNDNKSKTLKCSTLLVVGDNSPAVEAVVECNSRLNPINTTLLK 286
Query: 696 TKQADQKVKFELVQIDGVANVLTEAPEKVVVSLQYFLQGLGLVSNLRLS 842
+ G+ V+ P K+ + +YFLQG+G + + ++
Sbjct: 287 -----------MADCGGLPQVV--QPGKLTEAFKYFLQGMGYIPSASMT 322
>sp|Q9QYF9|NDRG3_MOUSE NDRG3 protein (Ndr3 protein)
Length = 375
Score = 89.7 bits (221), Expect = 9e-18
Identities = 73/289 (25%), Positives = 133/289 (46%), Gaps = 21/289 (7%)
Frame = +3
Query: 39 LGCNHYQ-YEEFLSNPKMAALSQKFVWIHVDLPGQGDGDEDLETNF--PSMEDIALDLQE 209
+G NH + F + M ++Q F HVD PGQ + T + P+M+++A L
Sbjct: 63 IGLNHKSCFNTFFNFEDMQEITQHFAVCHVDAPGQQEAAPSFPTGYQYPTMDELAEMLPP 122
Query: 210 LCEQMKLSNVLLFGEGAGANILARFAINNEHLVLGAILIHCVGSTASMIESLKDKVINWK 389
+ + + +++ G GAGA IL+RFA+N+ LV G +LI+ I+ I+W
Sbjct: 123 VLTHLSMKSIIGIGVGAGAYILSRFALNHPELVEGLVLIN--------IDPCAKGWIDWA 174
Query: 390 LNSI-GMNPTAESYLVLHRFGTQSVKFKNAETEVELKNVIESFKYNLKNSINPKNLYKFI 566
+ + G ++ H FG + E + L ++I++++ ++ IN +NL F+
Sbjct: 175 ASKLSGFTTNIVDIILAHHFGQE-------ELQANL-DLIQTYRLHIAQDINQENLQLFL 226
Query: 567 NTFITRRNL----------GERIAKLNVPTLFITG------AAAIHCKN-VHLLQETLLK 695
++ RR+L R+ L TL + G A + C + + + TLLK
Sbjct: 227 GSYNGRRDLEIERPILGQNDNRLKTLKCSTLLVVGDNSPAVEAVVECNSRLDPINTTLLK 286
Query: 696 TKQADQKVKFELVQIDGVANVLTEAPEKVVVSLQYFLQGLGLVSNLRLS 842
+ G+ V+ P K+ + +YFLQG+G + + ++
Sbjct: 287 -----------MADCGGLPQVV--QPGKLTEAFKYFLQGMGYIPSASMT 322
>sp|Q8BTG7|NDRG4_MOUSE NDRG4 protein
Length = 352
Score = 80.5 bits (197), Expect = 6e-15
Identities = 74/283 (26%), Positives = 121/283 (42%), Gaps = 17/283 (6%)
Frame = +3
Query: 39 LGCNHYQ-YEEFLSNPKMAALSQKFVWIHVDLPGQGDGDEDLETN--FPSMEDIALDLQE 209
+G NH + F + M +++ FV HVD PGQ G FPSME +A L
Sbjct: 39 VGLNHKLCFNTFFNFEDMQEITKHFVVCHVDAPGQQVGASQFPQGYQFPSMEQLAAMLPS 98
Query: 210 LCEQMKLSNVLLFGEGAGANILARFAINNEHLVLGAILIHCVGSTASMIESLKDKVINWK 389
+ + V+ G GAGA +LA+FA+ LV G +L++ I+ I+W
Sbjct: 99 VVQHFGFKYVIGIGVGAGAYVLAKFALIFPDLVEGLVLMN--------IDPNGKGWIDWA 150
Query: 390 LNSI-GMNPTAESYLVLHRFGTQSVKFKNAETEVELKNVIESFKYNLKNSINPKNLYKFI 566
+ G+ T ++ H F + + V +++S++ + N +N NL F
Sbjct: 151 ATKLSGLTSTLPDTVLSHLFSQEEL--------VNNTELVQSYRQQISNVVNQANLQLFW 202
Query: 567 NTFITRRNLG-------ERIAKLNVPTLFITGAAA------IHCKNVHLLQETLLKTKQA 707
N + +RR+L L P + + G A + C N L T K A
Sbjct: 203 NMYNSRRDLDINRPGTVPNAKTLRCPVMLVVGDNAPAEEGVVEC-NSKLDPTTTTFLKMA 261
Query: 708 DQKVKFELVQIDGVANVLTEAPEKVVVSLQYFLQGLGLVSNLR 836
D ++ Q P K+ + +YFLQG+G +++L+
Sbjct: 262 DSGGLPQVTQ-----------PGKLTEAFKYFLQGMGYIAHLK 293
>sp|Q9ULP0|NDRG4_HUMAN NDRG4 protein (Brain development-related molecule 1) (Vascular
smooth muscle cell associated protein 8) (SMAP-8)
Length = 352
Score = 79.3 bits (194), Expect = 1e-14
Identities = 74/283 (26%), Positives = 120/283 (42%), Gaps = 17/283 (6%)
Frame = +3
Query: 39 LGCNHYQ-YEEFLSNPKMAALSQKFVWIHVDLPGQGDGDEDLETN--FPSMEDIALDLQE 209
+G NH + F + M +++ FV HVD PGQ G FPSME +A L
Sbjct: 39 VGLNHKLCFNTFFNFEDMQEITKHFVVCHVDAPGQQVGASQFPQGYQFPSMEQLAAMLPS 98
Query: 210 LCEQMKLSNVLLFGEGAGANILARFAINNEHLVLGAILIHCVGSTASMIESLKDKVINWK 389
+ + V+ G GAGA +LA+FA+ LV G +L++ I+ I+W
Sbjct: 99 VVQHFGFKYVIGIGVGAGAYVLAKFALIFPDLVEGLVLVN--------IDPNGKGWIDWA 150
Query: 390 LNSI-GMNPTAESYLVLHRFGTQSVKFKNAETEVELKNVIESFKYNLKNSINPKNLYKFI 566
+ G+ T ++ H F + + V +++S++ + N +N NL F
Sbjct: 151 ATKLSGLTSTLPDTVLSHLFSQEEL--------VNNTELVQSYRQQIGNVVNQANLQLFW 202
Query: 567 NTFITRRNLG-------ERIAKLNVPTLFITGAAA------IHCKNVHLLQETLLKTKQA 707
N + +RR+L L P + + G A + C N L T K A
Sbjct: 203 NMYNSRRDLDINRPGTVPNAKTLRCPVMLVVGDNAPAEDGVVEC-NSKLDPTTTTFLKMA 261
Query: 708 DQKVKFELVQIDGVANVLTEAPEKVVVSLQYFLQGLGLVSNLR 836
D ++ Q P K+ + +YFLQG+G ++ L+
Sbjct: 262 DSGGLPQVTQ-----------PGKLTEAFKYFLQGMGYIAYLK 293
>sp|Q9Z2L9|NDRG4_RAT NDRG4 protein (Brain development-related molecule 1)
Length = 352
Score = 76.6 bits (187), Expect = 8e-14
Identities = 74/283 (26%), Positives = 121/283 (42%), Gaps = 17/283 (6%)
Frame = +3
Query: 39 LGCNHYQYEEFLSNPK-MAALSQKFVWIHVDLPGQGDGDEDLETN--FPSMEDIALDLQE 209
+G NH L N + M +++ FV HVD PGQ G FPSME +A L
Sbjct: 39 VGLNHKLCFNTLFNLEDMQEITKHFVVCHVDAPGQQVGASQFPQGYQFPSMEQLATMLPN 98
Query: 210 LCEQMKLSNVLLFGEGAGANILARFAINNEHLVLGAILIHCVGSTASMIESLKDKVINWK 389
+ + V+ G GAGA +LA+FA+ LV G +L++ I+ I+W
Sbjct: 99 VVQHFGFKYVIGIGVGAGAYVLAKFALIFPDLVEGLVLMN--------IDPNGKGWIDWA 150
Query: 390 LNSI-GMNPTAESYLVLHRFGTQSVKFKNAETEVELKNVIESFKYNLKNSINPKNLYKFI 566
+ G+ T ++ H F + + V +++S++ + + +N NL F
Sbjct: 151 ATKLSGLTSTLPDTVLSHLFSQEEL--------VNNTELVQSYRQQISSVVNQANLQLFW 202
Query: 567 NTFITRRNLG-------ERIAKLNVPTLFITGAAA------IHCKNVHLLQETLLKTKQA 707
N + +RR+L L P + + G A + C N L T K A
Sbjct: 203 NMYNSRRDLDINRPGTVPNAKTLRCPVMLVVGDNAPAEDGVVEC-NSKLDPTTTTFLKMA 261
Query: 708 DQKVKFELVQIDGVANVLTEAPEKVVVSLQYFLQGLGLVSNLR 836
D ++ Q P K+ + +YFLQG+G +++L+
Sbjct: 262 DSGGLPQVTQ-----------PGKLTEAFKYFLQGMGYIAHLK 293
>sp|O23969|SF21_HELAN Pollen-specific protein SF21
Length = 352
Score = 74.7 bits (182), Expect = 3e-13
Identities = 67/279 (24%), Positives = 124/279 (44%), Gaps = 5/279 (1%)
Frame = +3
Query: 30 FTHLGCNHYQYEE--FLSNPKMAALSQKFVWIHVDLPGQ--GDGDEDLETNFPSMEDIAL 197
+ L NH + F+S + L F H++ PG G ++ PS+ED+
Sbjct: 47 YPDLALNHMSCFQGLFVSPESASLLLHNFCIYHINPPGHELGAASIGIDDPVPSIEDLCD 106
Query: 198 DLQELCEQMKLSNVLLFGEGAGANILARFAINNEHLVLGAILIHCVGSTASMIESLKDKV 377
+ + +L +V+ G AGA IL F+I V G ILI + S E +K+
Sbjct: 107 QILVVLNYFRLGSVMCMGAMAGAYILTLFSIKYSERVTGLILISPICKAPSWTERFYNKL 166
Query: 378 INWKLNSIGMNPTAESYLVLHRFGTQSVKFKNAETEVELKNVIESFKYNLKNSINPKNLY 557
+ L GM + L++HR+ ++ V E+ +++ + + L + + N++
Sbjct: 167 TSKTLYYYGMCDLVKE-LLIHRYFSKEV---CGNPEIPESDMVLACR-KLLDERDSVNVW 221
Query: 558 KFINTFITRRNLGERIAKLNVPTLFITGAAAIHCKNVHLLQETLLKTKQADQKVKFELVQ 737
+++ +RR++ E + L T+ G ++ + E L A LV+
Sbjct: 222 RYLQAIDSRRDITEELKSLECKTIIFVGDSSPFHDEALQIAEKLGTNCSA-------LVE 274
Query: 738 IDGVANVLT-EAPEKVVVSLQYFLQGLGLVSNLRLSNEP 851
+ +++T E P +++ L+ FL+G GL R SN P
Sbjct: 275 VHACGSMVTQEQPHAMLIPLENFLKGFGLYRPCRYSNSP 313
>sp|Q9QYG0|NDRG2_MOUSE NDRG2 protein (Ndr2 protein)
Length = 371
Score = 70.5 bits (171), Expect = 6e-12
Identities = 63/254 (24%), Positives = 121/254 (47%), Gaps = 6/254 (2%)
Frame = +3
Query: 87 MAALSQKFVWIHVDLPGQGDGDE--DLETNFPSMEDIALDLQELCEQMKLSNVLLFGEGA 260
M + Q FV +HVD PG +G L +PS++ +A + + + + S ++ G GA
Sbjct: 88 MQEIIQNFVRVHVDAPGMEEGAPVFPLGYQYPSLDQLADMIPCILQYLNFSTIIGVGVGA 147
Query: 261 GANILARFAINNEHLVLGAILIHCVGSTASMIESLKDKVINWKLNSI-GMNPTAESYLVL 437
GA IL+R+A+N+ V G +LI+ I+ ++W + + G+ + ++
Sbjct: 148 GAYILSRYALNHPDTVEGLVLIN--------IDPNAKGWMDWAAHKLTGLTSSIPDMILG 199
Query: 438 HRFGTQSVKFKNAETEVELKNVIESFKYNLKNSINPKNLYKFINTFITRRNLG-ERIAK- 611
H F + + N+E +I+ ++ ++++ N +N+ + N++ RR+L ER +
Sbjct: 200 HLFSQEELS-GNSE-------LIQKYRGIIQHAPNLENIELYWNSYNNRRDLNFERGGET 251
Query: 612 -LNVPTLFITGAAAIHCKNVHLLQETLLKTKQADQKVKFELVQIDGVANVLTEAPEKVVV 788
L P + + G A H V L T+ + K+ D P K+
Sbjct: 252 TLKCPVMLVVGDQAPHEDAVVECNSKLDPTQTSFLKM------ADSGGQPQLTQPGKLTE 305
Query: 789 SLQYFLQGLGLVSN 830
+ +YFLQG+G +++
Sbjct: 306 AFKYFLQGMGYMAS 319
Database: Non-redundant SwissProt sequences
Posted date: Dec 6, 2005 7:40 AM
Number of letters in database: 68,354,980
Number of sequences in database: 184,735
Database: swissprot.01
Posted date: Dec 6, 2005 8:18 AM
Number of letters in database: 66,202,850
Number of sequences in database: 184,431
Lambda K H
0.318 0.134 0.401
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 100,520,390
Number of Sequences: 369166
Number of extensions: 2062343
Number of successful extensions: 5714
Number of sequences better than 10.0: 10
Number of HSP's better than 10.0 without gapping: 5513
Number of HSP's successfully gapped in prelim test: 0
Number of HSP's that attempted gapping in prelim test: 0
Number of HSP's gapped (non-prelim): 5692
length of database: 68,354,980
effective HSP length: 110
effective length of database: 48,034,130
effective search space used: 8694177530
frameshift window, decay const: 40, 0.1
T: 12
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)