Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= Dr_sW_007_J03
(855 letters)
Database: Non-redundant SwissProt sequences
184,735 sequences; 68,354,980 total letters
Score E
Sequences producing significant alignments: (bits) Value
sp|Q9QZA6|CD151_RAT Platelet endothelial tetraspan antigen ... 98 3e-20
sp|P28648|CD63_RAT CD63 antigen (AD1 antigen) 97 4e-20
sp|Q9XSK2|CD63_BOVIN CD63 antigen 97 7e-20
sp|O35566|C151_MOUSE Platelet-endothelial tetraspan antigen... 96 2e-19
sp|O60637|TSN3_HUMAN Tetraspanin-3 (Tspan-3) (Transmembrane... 92 2e-18
sp|P48509|CD151_HUMAN Platelet-endothelial tetraspan antige... 92 2e-18
sp|P08962|CD63_HUMAN CD63 antigen (Melanoma-associated anti... 91 3e-18
sp|Q9QY33|TSN3_MOUSE Tetraspanin-3 (Tspan-3) (Transmembrane... 89 1e-17
sp|P41731|CD63_MOUSE CD63 antigen 89 2e-17
sp|Q28709|CD63_RABIT CD63 antigen 89 2e-17
>sp|Q9QZA6|CD151_RAT Platelet endothelial tetraspan antigen 3 (CD151 antigen)
Length = 253
Score = 98.2 bits (243), Expect = 3e-20
Identities = 57/222 (25%), Positives = 102/222 (45%), Gaps = 4/222 (1%)
Frame = +2
Query: 83 WLSGLALIVIRAFFLANGTMKYVDEIINSSTNKGLLYGILAVGVIIFVIAFCGCCGAIRD 262
WL+GLA++ + + LA + Y+ ++ SST Y ++ GV++ V GCC ++
Sbjct: 28 WLAGLAVMAVGIWTLALKS-DYIS-LLASSTYLATAYILVVAGVVVMVTGVLGCCATFKE 85
Query: 263 SKMXXXXXXXXXXXXXXAEAVFGIYAIVKRPAVEEMIQNEFSKAFQKIY--GNDTTVTKT 436
+ E + GI A V + ++ K Y VT
Sbjct: 86 RRNLLRLYFILLLIIFLLEIIAGILAYVYYQQLNTELKENLKDTMIKRYHQSGHEGVTNA 145
Query: 437 VDSLQQAMQCCGATKMTDWLQSDWYQNSKNKTQPFPYSCCDPITSPCWEMGYDKKAF--T 610
VD LQQ CCG+ DW S+W ++ + ++ P SCC + + C + + +
Sbjct: 146 VDKLQQEFHCCGSNNSRDWRDSEWIRSGEADSRVVPDSCCKTVVTGCGKREHASNIYKVE 205
Query: 611 DGCIPKMFSYAKTYFPLVIGITLGIAFVEIFVVVCAFCLCRN 736
GCI K+ S+ + + ++ + +GIA V++F ++ CL R+
Sbjct: 206 GGCITKLESFIQEHLRVIGAVGIGIACVQVFGMIFTCCLYRS 247
>sp|P28648|CD63_RAT CD63 antigen (AD1 antigen)
Length = 238
Score = 97.4 bits (241), Expect = 4e-20
Identities = 59/183 (32%), Positives = 89/183 (48%), Gaps = 3/183 (1%)
Frame = +2
Query: 197 ILAVGVIIFVIAFCGCCGAIRDSKMXXXXXXXXXXXXXXAEAVFGIYAIVKRPAVEEMIQ 376
I+AVG +F++AF GCCGA +++ E I V R + ++
Sbjct: 57 IIAVGAFLFLVAFVGCCGACKENYCLMITFAIFLSLIMLVEVAVAIAGYVFR----DQVK 112
Query: 377 NEFSKAFQKIYGNDTTVTKT---VDSLQQAMQCCGATKMTDWLQSDWYQNSKNKTQPFPY 547
+EFSK+FQK N T KT +D LQ+ +CCGA+ TDW + + P
Sbjct: 113 SEFSKSFQKQMQNYLTDNKTATILDKLQKENKCCGASNYTDWERIPGMAKDR-----VPD 167
Query: 548 SCCDPITSPCWEMGYDKKAFTDGCIPKMFSYAKTYFPLVIGITLGIAFVEIFVVVCAFCL 727
SCC IT C + T GC+ + ++ + LV G LGIAFVE+ ++ + CL
Sbjct: 168 SCCINITVGCGNDFKESTIHTQGCVETIAAWLRKNVLLVAGAALGIAFVEVLGIIFSCCL 227
Query: 728 CRN 736
++
Sbjct: 228 VKS 230
>sp|Q9XSK2|CD63_BOVIN CD63 antigen
Length = 237
Score = 96.7 bits (239), Expect = 7e-20
Identities = 58/183 (31%), Positives = 87/183 (47%), Gaps = 3/183 (1%)
Frame = +2
Query: 197 ILAVGVIIFVIAFCGCCGAIRDSKMXXXXXXXXXXXXXXAEAVFGIYAIVKRPAVEEMIQ 376
I+AVG +F++AF GCCGA +++ E I V R + ++
Sbjct: 57 IIAVGAFLFLVAFVGCCGACKENYCLMITFAIFLSLIMLVEVAAAIAGYVFR----DKVR 112
Query: 377 NEFSKAFQ---KIYGNDTTVTKTVDSLQQAMQCCGATKMTDWLQSDWYQNSKNKTQPFPY 547
+EF+K F+ K Y D +D +Q+ +CCGA TDW + T P
Sbjct: 113 SEFNKDFRQQMKNYPKDNQTASILDKMQKDFECCGAANYTDW------EKILAVTNKVPD 166
Query: 548 SCCDPITSPCWEMGYDKKAFTDGCIPKMFSYAKTYFPLVIGITLGIAFVEIFVVVCAFCL 727
SCC IT C K T+GC+ K+ ++ + +V+ LGIAFVEI +V A CL
Sbjct: 167 SCCVNITHNCGINFVVKDIHTEGCVEKIAAWLRKNVLVVVAAALGIAFVEILGIVLACCL 226
Query: 728 CRN 736
++
Sbjct: 227 VKS 229
>sp|O35566|C151_MOUSE Platelet-endothelial tetraspan antigen 3 (PETA-3) (GP27) (Membrane
glycoprotein SFA-1) (CD151 antigen)
Length = 253
Score = 95.5 bits (236), Expect = 2e-19
Identities = 55/222 (24%), Positives = 102/222 (45%), Gaps = 4/222 (1%)
Frame = +2
Query: 83 WLSGLALIVIRAFFLANGTMKYVDEIINSSTNKGLLYGILAVGVIIFVIAFCGCCGAIRD 262
WL+GLA++ + + LA + Y+ ++ SST Y ++ GV++ V GCC ++
Sbjct: 28 WLAGLAVMAVGIWTLALKS-DYIS-LLASSTYLATAYILVVAGVVVMVTGVLGCCATFKE 85
Query: 263 SKMXXXXXXXXXXXXXXAEAVFGIYAIVKRPAVEEMIQNEFSKAFQKIY--GNDTTVTKT 436
+ E + GI A V + ++ K Y V+
Sbjct: 86 RRNLLRLYFILLLIIFLLEIIAGILAYVYYQQLNTELKENLKDTMVKRYHQSGHEGVSSA 145
Query: 437 VDSLQQAMQCCGATKMTDWLQSDWYQNSKNKTQPFPYSCCDPITSPCWEMGYDKKAF--T 610
VD LQQ CCG+ DW S+W ++ + ++ P SCC + + C + + +
Sbjct: 146 VDKLQQEFHCCGSNNSQDWQDSEWIRSGEADSRVVPDSCCKTMVAGCGKRDHASNIYKVE 205
Query: 611 DGCIPKMFSYAKTYFPLVIGITLGIAFVEIFVVVCAFCLCRN 736
GCI K+ ++ + + ++ + +GIA V++F ++ CL R+
Sbjct: 206 GGCITKLETFIQEHLRVIGAVGIGIACVQVFGMIFTCCLYRS 247
>sp|O60637|TSN3_HUMAN Tetraspanin-3 (Tspan-3) (Transmembrane 4 superfamily member 8)
(Tetraspanin TM4-A)
Length = 253
Score = 91.7 bits (226), Expect = 2e-18
Identities = 50/184 (27%), Positives = 83/184 (45%), Gaps = 3/184 (1%)
Frame = +2
Query: 197 ILAVGVIIFVIAFCGCCGAIRDSKMXXXXXXXXXXXXXXAEAVFGIYAIVKRPAVEEMIQ 376
I+AVG ++F+I GCC IR+S+ E V + V R VE +
Sbjct: 57 IIAVGALLFIIGLIGCCATIRESRCGLATFVIILLLVFVTEVVVVVLGYVYRAKVENEVD 116
Query: 377 NEFSKAFQKIYG-NDTTVTKTVDSLQQAMQCCGATKMTDWLQSDWYQNSKNKTQPFPYSC 553
K ++ G N ++ +D +Q+ + CCG +DW +DW++ +KN Q P SC
Sbjct: 117 RSIQKVYKTYNGTNPDAASRAIDYVQRQLHCCGIHNYSDWENTDWFKETKN--QSVPLSC 174
Query: 554 CDPITSPC-WEMGYDKKAFTDGCIPKMFSYAKTYFPLVIGITLGIAFVEIFVVVCA-FCL 727
C S C + + + +GC + + VI L A +++ ++CA L
Sbjct: 175 CRETASNCNGSLAHPSDLYAEGCEALVVKKLQEIMMHVIWAALAFAAIQLLGMLCACIVL 234
Query: 728 CRNT 739
CR +
Sbjct: 235 CRRS 238
>sp|P48509|CD151_HUMAN Platelet-endothelial tetraspan antigen 3 (PETA-3) (GP27) (Membrane
glycoprotein SFA-1) (CD151 antigen) (Tetraspanin-24)
(Tspan-24)
Length = 253
Score = 91.7 bits (226), Expect = 2e-18
Identities = 52/222 (23%), Positives = 98/222 (44%), Gaps = 4/222 (1%)
Frame = +2
Query: 83 WLSGLALIVIRAFFLANGTMKYVDEIINSSTNKGLLYGILAVGVIIFVIAFCGCCGAIRD 262
WL+GLA++ + + LA + Y+ ++ S T Y ++ G ++ V GCC ++
Sbjct: 28 WLAGLAVMAVGIWTLALKS-DYIS-LLASGTYLATAYILVVAGTVVMVTGVLGCCATFKE 85
Query: 263 SKMXXXXXXXXXXXXXXAEAVFGIYAIVKRPAVEEMIQNEFSKAFQKIY--GNDTTVTKT 436
+ E + GI A + ++ + Y VT
Sbjct: 86 RRNLLRLYFILLLIIFLLEIIAGILAYAYYQQLNTELKENLKDTMTRRYHQSGHEAVTSA 145
Query: 437 VDSLQQAMQCCGATKMTDWLQSDWYQNSKNKTQPFPYSCCDPITSPCWEMGYDKKAF--T 610
VD LQQ CCG+ DW S+W ++ + + P SCC + + C + + +
Sbjct: 146 VDQLQQEFHCCGSNNSQDWRDSEWIRSQEAGGRVVPDSCCKTVVALCGQRDHASNIYKVE 205
Query: 611 DGCIPKMFSYAKTYFPLVIGITLGIAFVEIFVVVCAFCLCRN 736
GCI K+ ++ + + ++ + +GIA V++F ++ CL R+
Sbjct: 206 GGCITKLETFIQEHLRVIGAVGIGIACVQVFGMIFTCCLYRS 247
>sp|P08962|CD63_HUMAN CD63 antigen (Melanoma-associated antigen ME491)
(Lysosome-associated membrane glycoprotein 3) (LAMP-3)
(Ocular melanoma-associated antigen) (OMA81H)
(Granulophysin) (Tetraspanin-30) (Tspan-30)
Length = 238
Score = 91.3 bits (225), Expect = 3e-18
Identities = 61/194 (31%), Positives = 90/194 (46%), Gaps = 1/194 (0%)
Frame = +2
Query: 158 IINSSTNKGLL-YGILAVGVIIFVIAFCGCCGAIRDSKMXXXXXXXXXXXXXXAEAVFGI 334
II +T LL I+AVGV +F++AF GCCGA +++ E I
Sbjct: 43 IIQGATPGSLLPVVIIAVGVFLFLVAFVGCCGACKENYCLMITFAIFLSLIMLVEVAAAI 102
Query: 335 YAIVKRPAVEEMIQNEFSKAFQKIYGNDTTVTKTVDSLQQAMQCCGATKMTDWLQSDWYQ 514
V R V N F + + N+ T + +D +Q +CCGA TDW +
Sbjct: 103 AGYVFRDKVMSEFNNNFRQQMENYPKNNHTAS-ILDRMQADFKCCGAANYTDWEKIP--S 159
Query: 515 NSKNKTQPFPYSCCDPITSPCWEMGYDKKAFTDGCIPKMFSYAKTYFPLVIGITLGIAFV 694
SKN+ P SCC +T C +K +GC+ K+ + + +V LGIAFV
Sbjct: 160 MSKNRV---PDSCCINVTVGCGINFNEKAIHKEGCVEKIGGWLRKNVLVVAAAALGIAFV 216
Query: 695 EIFVVVCAFCLCRN 736
E+ +V A CL ++
Sbjct: 217 EVLGIVFACCLVKS 230
>sp|Q9QY33|TSN3_MOUSE Tetraspanin-3 (Tspan-3) (Transmembrane 4 superfamily member 8)
(Tetraspanin TM4-A) (OSP-associated protein 1) (OAP-1)
Length = 253
Score = 89.4 bits (220), Expect = 1e-17
Identities = 49/184 (26%), Positives = 81/184 (44%), Gaps = 3/184 (1%)
Frame = +2
Query: 197 ILAVGVIIFVIAFCGCCGAIRDSKMXXXXXXXXXXXXXXAEAVFGIYAIVKRPAVEEMIQ 376
I+AVG ++F+I GCC IR+S+ E V + V R VE +
Sbjct: 57 IIAVGALLFIIGLIGCCATIRESRCGLATFVFILLLVFVTEVVVVVLGYVYRAKVENEVD 116
Query: 377 NEFSKAFQKIYG-NDTTVTKTVDSLQQAMQCCGATKMTDWLQSDWYQNSKNKTQPFPYSC 553
K ++ G N ++ +D +Q+ + CCG +DW +DW++ +KN Q P SC
Sbjct: 117 RSIQKVYKTYNGTNSDAASRAIDYVQRQLHCCGIHNYSDWENTDWFKETKN--QSVPLSC 174
Query: 554 CDPITSPC-WEMGYDKKAFTDGCIPKMFSYAKTYFPLVIGITLGIAFVEIFVVVCA-FCL 727
C C + + +GC + + VI L A +++ ++CA L
Sbjct: 175 CRETAKSCNGSLANPSDLYAEGCEALVVKKLQEILMHVIWAALAFAAIQLLGMLCACIVL 234
Query: 728 CRNT 739
CR +
Sbjct: 235 CRRS 238
>sp|P41731|CD63_MOUSE CD63 antigen
Length = 238
Score = 89.0 bits (219), Expect = 2e-17
Identities = 54/183 (29%), Positives = 83/183 (45%), Gaps = 3/183 (1%)
Frame = +2
Query: 197 ILAVGVIIFVIAFCGCCGAIRDSKMXXXXXXXXXXXXXXAEAVFGIYAIVKRPAVEEMIQ 376
I+AVG +F++AF GCCGA +++ E I V R + ++
Sbjct: 57 IIAVGAFLFLVAFVGCCGACKENYCLMITFAIFLSLIMLVEVAVAIAGYVFR----DQVK 112
Query: 377 NEFSKAFQKIYGN---DTTVTKTVDSLQQAMQCCGATKMTDWLQSDWYQNSKNKTQPFPY 547
+EF+K+FQ+ N D +D LQ+ CCGA+ TDW + P
Sbjct: 113 SEFNKSFQQQMQNYLKDNKTATILDKLQKENNCCGASNYTDWENIPGMAKDR-----VPD 167
Query: 548 SCCDPITSPCWEMGYDKKAFTDGCIPKMFSYAKTYFPLVIGITLGIAFVEIFVVVCAFCL 727
SCC IT C + T GC+ + + + LV LGIAFVE+ ++ + CL
Sbjct: 168 SCCINITVGCGNDFKESTIHTQGCVETIAIWLRKNILLVAAAALGIAFVEVLGIIFSCCL 227
Query: 728 CRN 736
++
Sbjct: 228 VKS 230
>sp|Q28709|CD63_RABIT CD63 antigen
Length = 238
Score = 88.6 bits (218), Expect = 2e-17
Identities = 52/180 (28%), Positives = 77/180 (42%)
Frame = +2
Query: 197 ILAVGVIIFVIAFCGCCGAIRDSKMXXXXXXXXXXXXXXAEAVFGIYAIVKRPAVEEMIQ 376
I+AVG +F++AF GCCG +++ E I V R V
Sbjct: 57 IIAVGAFLFLVAFVGCCGTCKENYCLMITFAIFLSLIMLVEVAAAIAGYVFRDKVMSEFN 116
Query: 377 NEFSKAFQKIYGNDTTVTKTVDSLQQAMQCCGATKMTDWLQSDWYQNSKNKTQPFPYSCC 556
+F + Q Y D +D +Q+ CCGA TDW + P SCC
Sbjct: 117 KDFRQQMQN-YSTDNQTALILDRMQKDFTCCGAANYTDWATIPGMTRDR-----VPDSCC 170
Query: 557 DPITSPCWEMGYDKKAFTDGCIPKMFSYAKTYFPLVIGITLGIAFVEIFVVVCAFCLCRN 736
+TS C K + +GC+ K+ + + +V LGIAFVE+ +V A CL ++
Sbjct: 171 VNVTSGCGVKFNVKDIYVEGCVEKIGLWLRKNVLVVAAAALGIAFVEVLGIVFACCLVKS 230
Database: Non-redundant SwissProt sequences
Posted date: Dec 6, 2005 7:40 AM
Number of letters in database: 68,354,980
Number of sequences in database: 184,735
Database: swissprot.01
Posted date: Dec 6, 2005 8:18 AM
Number of letters in database: 66,202,850
Number of sequences in database: 184,431
Lambda K H
0.318 0.134 0.401
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 97,311,920
Number of Sequences: 369166
Number of extensions: 1937243
Number of successful extensions: 5022
Number of sequences better than 10.0: 10
Number of HSP's better than 10.0 without gapping: 4781
Number of HSP's successfully gapped in prelim test: 0
Number of HSP's that attempted gapping in prelim test: 0
Number of HSP's gapped (non-prelim): 4940
length of database: 68,354,980
effective HSP length: 109
effective length of database: 48,218,865
effective search space used: 8438301375
frameshift window, decay const: 40, 0.1
T: 12
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)