Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= Dr_sW_007_I01
(814 letters)
Database: Non-redundant SwissProt sequences
184,735 sequences; 68,354,980 total letters
Score E
Sequences producing significant alignments: (bits) Value
sp|Q95029|CATL_DROME Cathepsin L precursor (Cysteine protei... 235 9e-62
sp|Q9GLE3|CATK_PIG Cathepsin K precursor 233 5e-61
sp|P43235|CATK_HUMAN Cathepsin K precursor (Cathepsin O) (C... 233 6e-61
sp|P61277|CATK_MACMU Cathepsin K precursor >gi|47117667|sp|... 233 6e-61
sp|Q24940|CATLP_FASHE Cathepsin L-like proteinase precursor 232 1e-60
sp|P25782|CYSP2_HOMAM Digestive cysteine proteinase 2 precu... 231 2e-60
sp|P55097|CATK_MOUSE Cathepsin K precursor 230 4e-60
sp|P43236|CATK_RABIT Cathepsin K precursor (OC-2 protein) 230 4e-60
sp|O60911|CATL2_HUMAN Cathepsin L2 precursor (Cathepsin V) ... 229 9e-60
sp|P07711|CATL_HUMAN Cathepsin L precursor (Major excreted ... 228 2e-59
>sp|Q95029|CATL_DROME Cathepsin L precursor (Cysteine proteinase 1) [Contains: Cathepsin
L heavy chain; Cathepsin L light chain]
Length = 341
Score = 235 bits (600), Expect = 9e-62
Identities = 132/267 (49%), Positives = 172/267 (64%), Gaps = 14/267 (5%)
Frame = +3
Query: 54 EWQVFKTKFNKNYT-AIDELVRKTIWIENIKYIQHHNVKYDLGHHSHSLGINEFSDLTYK 230
EW FK + KNY +E R I+ EN I HN ++ G S L +N+++DL +
Sbjct: 28 EWHTFKLEHRKNYQDETEERFRLKIFNENKHKIAKHNQRFAEGKVSFKLAVNKYADLLHH 87
Query: 231 EFEKL-----YLLSKNIEYND----GIDYLPPLNIDNLPDSVDWRTKGYVTNVKNQGQCG 383
EF +L Y L K + D G+ ++ P ++ LP SVDWRTKG VT VK+QG CG
Sbjct: 88 EFRQLMNGFNYTLHKQLRAADESFKGVTFISPAHV-TLPKSVDWRTKGAVTAVKDQGHCG 146
Query: 384 SCWAFSTTGSLEGQHFRKHKVLQNISEQQLVDCVTK--NSGCNGGWMNIAFEYISSH-GI 554
SCWAFS+TG+LEGQHFRK VL ++SEQ LVDC TK N+GCNGG M+ AF YI + GI
Sbjct: 147 SCWAFSSTGALEGQHFRKSGVLVSLSEQNLVDCSTKYGNNGCNGGLMDNAFRYIKDNGGI 206
Query: 555 ESEDNYPYQAKQGNCVFDKSKVVANCKGFQNINSCNEKDLAVAVATVGPISVAIDVGY-S 731
++E +YPY+A +C F+K V A +GF +I +EK +A AVATVGP+SVAID + S
Sbjct: 207 DTEKSYPYEAIDDSCHFNKGTVGATDRGFTDIPQGDEKKMAEAVATVGPVSVAIDASHES 266
Query: 732 FQQYKQGVYYEAKCDPTIQNHAVLVVG 812
FQ Y +GVY E +CD +H VLVVG
Sbjct: 267 FQFYSEGVYNEPQCDAQNLDHGVLVVG 293
>sp|Q9GLE3|CATK_PIG Cathepsin K precursor
Length = 330
Score = 233 bits (594), Expect = 5e-61
Identities = 121/265 (45%), Positives = 171/265 (64%), Gaps = 7/265 (2%)
Frame = +3
Query: 39 EEFNAEWQVFKTKFNKNYTA-IDELVRKTIWIENIKYIQHHNVKYDLGHHSHSLGINEFS 215
E + +W+++K + K Y + +DE+ R+ IW +N+K+I HN++ LG H++ L +N
Sbjct: 21 EILDTQWELWKKTYRKQYNSKVDEISRRLIWEKNLKHISIHNLEASLGVHTYELAMNHLG 80
Query: 216 DLTYKEFEK----LYLLSKNIEYNDGIDYLPPLNIDNLPDSVDWRTKGYVTNVKNQGQCG 383
D+T +E + L + + ND + Y+P PDS+D+R KGYVT VKNQGQCG
Sbjct: 81 DMTSEEVVQKMTGLKVPPSHSRSNDTL-YIPDWE-GRTPDSIDYRKKGYVTPVKNQGQCG 138
Query: 384 SCWAFSTTGSLEGQHFRKHKVLQNISEQQLVDCVTKNSGCNGGWMNIAFEYI-SSHGIES 560
SCWAFS+ G+LEGQ +K L N+S Q LVDCV++N GC GG+M AF+Y+ + GI+S
Sbjct: 139 SCWAFSSVGALEGQLKKKTGKLLNLSPQNLVDCVSENDGCGGGYMTNAFQYVQKNRGIDS 198
Query: 561 EDNYPYQAKQGNCVFDKSKVVANCKGFQNINSCNEKDLAVAVATVGPISVAIDVGY-SFQ 737
ED YPY + NC+++ + A C+G++ I NEK L AVA VGP+SVAID SFQ
Sbjct: 199 EDAYPYVGQDENCMYNPTGKAAKCRGYREIPEGNEKALKRAVARVGPVSVAIDASLTSFQ 258
Query: 738 QYKQGVYYEAKCDPTIQNHAVLVVG 812
Y +GVYY+ C+ NHAVL VG
Sbjct: 259 FYSKGVYYDENCNSDNLNHAVLAVG 283
>sp|P43235|CATK_HUMAN Cathepsin K precursor (Cathepsin O) (Cathepsin X) (Cathepsin O2)
Length = 329
Score = 233 bits (593), Expect = 6e-61
Identities = 122/264 (46%), Positives = 170/264 (64%), Gaps = 6/264 (2%)
Frame = +3
Query: 39 EEFNAEWQVFKTKFNKNYT-AIDELVRKTIWIENIKYIQHHNVKYDLGHHSHSLGINEFS 215
E + W+++K K Y +DE+ R+ IW +N+KYI HN++ LG H++ L +N
Sbjct: 20 EILDTHWELWKKTHRKQYNNKVDEISRRLIWEKNLKYISIHNLEASLGVHTYELAMNHLG 79
Query: 216 DLTYKEF-EKLYLLSKNIEYNDGID--YLPPLNIDNLPDSVDWRTKGYVTNVKNQGQCGS 386
D+T +E +K+ L + ++ D Y+P PDSVD+R KGYVT VKNQGQCGS
Sbjct: 80 DMTSEEVVQKMTGLKVPLSHSRSNDTLYIPEWE-GRAPDSVDYRKKGYVTPVKNQGQCGS 138
Query: 387 CWAFSTTGSLEGQHFRKHKVLQNISEQQLVDCVTKNSGCNGGWMNIAFEYI-SSHGIESE 563
CWAFS+ G+LEGQ +K L N+S Q LVDCV++N GC GG+M AF+Y+ + GI+SE
Sbjct: 139 CWAFSSVGALEGQLKKKTGKLLNLSPQNLVDCVSENDGCGGGYMTNAFQYVQKNRGIDSE 198
Query: 564 DNYPYQAKQGNCVFDKSKVVANCKGFQNINSCNEKDLAVAVATVGPISVAIDVGY-SFQQ 740
D YPY ++ +C+++ + A C+G++ I NEK L AVA VGP+SVAID SFQ
Sbjct: 199 DAYPYVGQEESCMYNPTGKAAKCRGYREIPEGNEKALKRAVARVGPVSVAIDASLTSFQF 258
Query: 741 YKQGVYYEAKCDPTIQNHAVLVVG 812
Y +GVYY+ C+ NHAVL VG
Sbjct: 259 YSKGVYYDESCNSDNLNHAVLAVG 282
>sp|P61277|CATK_MACMU Cathepsin K precursor
sp|P61276|CATK_MACFA Cathepsin K precursor
Length = 329
Score = 233 bits (593), Expect = 6e-61
Identities = 122/265 (46%), Positives = 171/265 (64%), Gaps = 7/265 (2%)
Frame = +3
Query: 39 EEFNAEWQVFKTKFNKNYTA-IDELVRKTIWIENIKYIQHHNVKYDLGHHSHSLGINEFS 215
E + W+++K K Y + +DE+ R+ IW +N+KYI HN++ LG H++ L +N
Sbjct: 20 EILDTHWELWKKTHRKQYNSKVDEISRRLIWEKNLKYISIHNLEASLGVHTYELAMNHLG 79
Query: 216 DLTYKEFEK----LYLLSKNIEYNDGIDYLPPLNIDNLPDSVDWRTKGYVTNVKNQGQCG 383
D+T +E + L + + + ND + Y+P PDSVD+R KGYVT VKNQGQCG
Sbjct: 80 DMTNEEVVQKMTGLKVPASHSRSNDTL-YIPDWE-GRAPDSVDYRKKGYVTPVKNQGQCG 137
Query: 384 SCWAFSTTGSLEGQHFRKHKVLQNISEQQLVDCVTKNSGCNGGWMNIAFEYI-SSHGIES 560
SCWAFS+ G+LEGQ +K L N+S Q LVDCV++N GC GG+M AF+Y+ + GI+S
Sbjct: 138 SCWAFSSVGALEGQLKKKTGKLLNLSPQNLVDCVSENDGCGGGYMTNAFQYVQKNRGIDS 197
Query: 561 EDNYPYQAKQGNCVFDKSKVVANCKGFQNINSCNEKDLAVAVATVGPISVAIDVGY-SFQ 737
ED YPY ++ +C+++ + A C+G++ I NEK L AVA VGP+SVAID SFQ
Sbjct: 198 EDAYPYVGQEESCMYNPTGKAAKCRGYREIPEGNEKALKRAVARVGPVSVAIDASLTSFQ 257
Query: 738 QYKQGVYYEAKCDPTIQNHAVLVVG 812
Y +GVYY+ C+ NHAVL VG
Sbjct: 258 FYSKGVYYDESCNSDNLNHAVLAVG 282
>sp|Q24940|CATLP_FASHE Cathepsin L-like proteinase precursor
Length = 326
Score = 232 bits (591), Expect = 1e-60
Identities = 109/256 (42%), Positives = 163/256 (63%), Gaps = 4/256 (1%)
Frame = +3
Query: 57 WQVFKTKFNKNYTAIDELVRKTIWIENIKYIQHHNVKYDLGHHSHSLGINEFSDLTYKEF 236
W +K +NK Y D+ R+ IW +N+K+IQ HN+++DLG +++LG+N+F+D+T++EF
Sbjct: 21 WHQWKRMYNKEYNGADDQHRRNIWEKNVKHIQEHNLRHDLGLVTYTLGLNQFTDMTFEEF 80
Query: 237 EKLYLLSKNIEYNDGIDYLPPLNIDN--LPDSVDWRTKGYVTNVKNQGQCGSCWAFSTTG 410
+ YL + +D + + P +N +PD +DWR GYVT VK+QG CGSCWAFSTTG
Sbjct: 81 KAKYLTEMS-RASDILSHGVPYEANNRAVPDKIDWRESGYVTEVKDQGNCGSCWAFSTTG 139
Query: 411 SLEGQHFRKHKVLQNISEQQLVDCVTK--NSGCNGGWMNIAFEYISSHGIESEDNYPYQA 584
++EGQ+ + + + SEQQLVDC N+GC+GG M A++Y+ G+E+E +YPY A
Sbjct: 140 TMEGQYMKNERTSISFSEQQLVDCSGPWGNNGCSGGLMENAYQYLKQFGLETESSYPYTA 199
Query: 585 KQGNCVFDKSKVVANCKGFQNINSCNEKDLAVAVATVGPISVAIDVGYSFQQYKQGVYYE 764
+G C ++K VA G+ ++S +E +L V P +VA+DV F Y+ G+Y
Sbjct: 200 VEGQCRYNKQLGVAKVTGYYTVHSGSEVELKNLVGARRPAAVAVDVESDFMMYRSGIYQS 259
Query: 765 AKCDPTIQNHAVLVVG 812
C P NHAVL VG
Sbjct: 260 QTCSPLRVNHAVLAVG 275
>sp|P25782|CYSP2_HOMAM Digestive cysteine proteinase 2 precursor
Length = 323
Score = 231 bits (589), Expect = 2e-60
Identities = 125/259 (48%), Positives = 163/259 (62%), Gaps = 7/259 (2%)
Frame = +3
Query: 57 WQVFKTKFNKNYT-AIDELVRKTIWIENIKYIQHHNVKYDLGHHSHSLGINEFSDLTYKE 233
W+ FK K+ + Y A ++ R+ I+ +N KYI+ N KY+ G + +L +N+F D+T +E
Sbjct: 20 WEHFKGKYGRQYVDAEEDSYRRVIFEQNQKYIEEFNKKYENGEVTFNLAMNKFGDMTLEE 79
Query: 234 FEKLYLLSKNIEYNDG--IDYLPPLNIDNLPDSVDWRTKGYVTNVKNQGQCGSCWAFSTT 407
F + + NI + P VDWRTKG VT VK+QGQCGSCWAFSTT
Sbjct: 80 FNAV--MKGNIPRRSAPVSVFYPKKETGPQATEVDWRTKGAVTPVKDQGQCGSCWAFSTT 137
Query: 408 GSLEGQHFRKHKVLQNISEQQLVDCVTK--NSGCNGGWMNIAFEYI-SSHGIESEDNYPY 578
GSLEGQHF K L +++EQQLVDC GCNGGWMN AF+YI +++GI++E YPY
Sbjct: 138 GSLEGQHFLKTGSLISLAEQQLVDCSRPYGPQGCNGGWMNDAFDYIKANNGIDTEAAYPY 197
Query: 579 QAKQGNCVFDKSKVVANCKGFQNINSCNEKDLAVAVATVGPISVAIDVGY-SFQQYKQGV 755
+A+ G+C FD + V A C G NI S +E L AV +GPISV ID + SFQ Y GV
Sbjct: 198 EARDGSCRFDSNSVAATCSGHTNIASGSETGLQQAVRDIGPISVTIDAAHSSFQFYSSGV 257
Query: 756 YYEAKCDPTIQNHAVLVVG 812
YYE C P+ +HAVL VG
Sbjct: 258 YYEPSCSPSYLDHAVLAVG 276
>sp|P55097|CATK_MOUSE Cathepsin K precursor
Length = 329
Score = 230 bits (586), Expect = 4e-60
Identities = 120/264 (45%), Positives = 168/264 (63%), Gaps = 6/264 (2%)
Frame = +3
Query: 39 EEFNAEWQVFKTKFNKNYTA-IDELVRKTIWIENIKYIQHHNVKYDLGHHSHSLGINEFS 215
E + +W+++K K Y + +DE+ R+ IW +N+K I HN++ LG H++ L +N
Sbjct: 20 EMLDTQWELWKKTHQKQYNSKVDEISRRLIWEKNLKQISAHNLEASLGVHTYELAMNHLG 79
Query: 216 DLTYKEFEKLYL---LSKNIEYNDGIDYLPPLNIDNLPDSVDWRTKGYVTNVKNQGQCGS 386
D+T +E + + + Y++ Y P +PDS+D+R KGYVT VKNQGQCGS
Sbjct: 80 DMTSEEVVQKMTGLRIPPSRSYSNDTLYTPEWE-GRVPDSIDYRKKGYVTPVKNQGQCGS 138
Query: 387 CWAFSTTGSLEGQHFRKHKVLQNISEQQLVDCVTKNSGCNGGWMNIAFEYISSH-GIESE 563
CWAFS+ G+LEGQ +K L +S Q LVDCVT+N GC GG+M AF+Y+ + GI+SE
Sbjct: 139 CWAFSSAGALEGQLKKKTGKLLALSPQNLVDCVTENYGCGGGYMTTAFQYVQQNGGIDSE 198
Query: 564 DNYPYQAKQGNCVFDKSKVVANCKGFQNINSCNEKDLAVAVATVGPISVAIDVGY-SFQQ 740
D YPY + +C+++ + A C+G++ I NEK L AVA VGPISV+ID SFQ
Sbjct: 199 DAYPYVGQDESCMYNATAKAAKCRGYREIPVGNEKALKRAVARVGPISVSIDASLASFQF 258
Query: 741 YKQGVYYEAKCDPTIQNHAVLVVG 812
Y +GVYY+ CD NHAVLVVG
Sbjct: 259 YSRGVYYDENCDRDNVNHAVLVVG 282
>sp|P43236|CATK_RABIT Cathepsin K precursor (OC-2 protein)
Length = 329
Score = 230 bits (586), Expect = 4e-60
Identities = 120/265 (45%), Positives = 170/265 (64%), Gaps = 7/265 (2%)
Frame = +3
Query: 39 EEFNAEWQVFKTKFNKNYTA-IDELVRKTIWIENIKYIQHHNVKYDLGHHSHSLGINEFS 215
E + +W+++K ++K Y + +DE+ R+ IW +N+K+I HN++ LG H++ L +N
Sbjct: 20 EILDTQWELWKKTYSKQYNSKVDEISRRLIWEKNLKHISIHNLEASLGVHTYELAMNHLG 79
Query: 216 DLTYKEFEK----LYLLSKNIEYNDGIDYLPPLNIDNLPDSVDWRTKGYVTNVKNQGQCG 383
D+T +E + L + ND + Y+P PDS+D+R KGYVT VKNQGQCG
Sbjct: 80 DMTSEEVVQKMTGLKVPPSRSHSNDTL-YIPDWE-GRTPDSIDYRKKGYVTPVKNQGQCG 137
Query: 384 SCWAFSTTGSLEGQHFRKHKVLQNISEQQLVDCVTKNSGCNGGWMNIAFEYIS-SHGIES 560
SCWAFS+ G+LEGQ +K L N+S Q LVDCV++N GC GG+M AF+Y+ + GI+S
Sbjct: 138 SCWAFSSVGALEGQLKKKTGKLLNLSPQNLVDCVSENYGCGGGYMTNAFQYVQRNRGIDS 197
Query: 561 EDNYPYQAKQGNCVFDKSKVVANCKGFQNINSCNEKDLAVAVATVGPISVAIDVGY-SFQ 737
ED YPY + +C+++ + A C+G++ I NEK L AVA VGP+SVAID SFQ
Sbjct: 198 EDAYPYVGQDESCMYNPTGKAAKCRGYREIPEGNEKALKRAVARVGPVSVAIDASLTSFQ 257
Query: 738 QYKQGVYYEAKCDPTIQNHAVLVVG 812
Y +GVYY+ C NHAVL VG
Sbjct: 258 FYSKGVYYDENCSSDNVNHAVLAVG 282
>sp|O60911|CATL2_HUMAN Cathepsin L2 precursor (Cathepsin V) (Cathepsin U)
Length = 334
Score = 229 bits (583), Expect = 9e-60
Identities = 122/262 (46%), Positives = 164/262 (62%), Gaps = 4/262 (1%)
Frame = +3
Query: 39 EEFNAEWQVFKTKFNKNYTAIDELVRKTIWIENIKYIQHHNVKYDLGHHSHSLGINEFSD 218
+ + +W +K + Y A +E R+ +W +N+K I+ HN +Y G H ++ +N F D
Sbjct: 23 QNLDTKWYQWKATHRRLYGANEEGWRRAVWEKNMKMIELHNGEYSQGKHGFTMAMNAFGD 82
Query: 219 LTYKEFEKLYLLSKNIEYNDGIDYLPPLNIDNLPDSVDWRTKGYVTNVKNQGQCGSCWAF 398
+T +EF ++ +N ++ G + PL +D LP SVDWR KGYVT VKNQ QCGSCWAF
Sbjct: 83 MTNEEFRQMMGCFRNQKFRKGKVFREPLFLD-LPKSVDWRKKGYVTPVKNQKQCGSCWAF 141
Query: 399 STTGSLEGQHFRKHKVLQNISEQQLVDCVTK--NSGCNGGWMNIAFEYISSH-GIESEDN 569
S TG+LEGQ FRK L ++SEQ LVDC N GCNGG+M AF+Y+ + G++SE++
Sbjct: 142 SATGALEGQMFRKTGKLVSLSEQNLVDCSRPQGNQGCNGGFMARAFQYVKENGGLDSEES 201
Query: 570 YPYQAKQGNCVFDKSKVVANCKGFQNINSCNEKDLAVAVATVGPISVAIDVGY-SFQQYK 746
YPY A C + VAN GF + EK L AVATVGPISVA+D G+ SFQ YK
Sbjct: 202 YPYVAVDEICKYRPENSVANDTGFTVVAPGKEKALMKAVATVGPISVAMDAGHSSFQFYK 261
Query: 747 QGVYYEAKCDPTIQNHAVLVVG 812
G+Y+E C +H VLVVG
Sbjct: 262 SGIYFEPDCSSKNLDHGVLVVG 283
>sp|P07711|CATL_HUMAN Cathepsin L precursor (Major excreted protein) (MEP) [Contains:
Cathepsin L heavy chain; Cathepsin L light chain]
Length = 333
Score = 228 bits (580), Expect = 2e-59
Identities = 124/258 (48%), Positives = 167/258 (64%), Gaps = 4/258 (1%)
Frame = +3
Query: 51 AEWQVFKTKFNKNYTAIDELVRKTIWIENIKYIQHHNVKYDLGHHSHSLGINEFSDLTYK 230
A+W +K N+ Y +E R+ +W +N+K I+ HN +Y G HS ++ +N F D+T +
Sbjct: 27 AQWTKWKAMHNRLYGMNEEGWRRAVWEKNMKMIELHNQEYREGKHSFTMAMNAFGDMTSE 86
Query: 231 EFEKLYLLSKNIEYNDGIDYLPPLNIDNLPDSVDWRTKGYVTNVKNQGQCGSCWAFSTTG 410
EF ++ +N + G + PL + P SVDWR KGYVT VKNQGQCGSCWAFS TG
Sbjct: 87 EFRQVMNGFQNRKPRKGKVFQEPLFYE-APRSVDWREKGYVTPVKNQGQCGSCWAFSATG 145
Query: 411 SLEGQHFRKHKVLQNISEQQLVDC--VTKNSGCNGGWMNIAFEYISSH-GIESEDNYPYQ 581
+LEGQ FRK L ++SEQ LVDC N GCNGG M+ AF+Y+ + G++SE++YPY+
Sbjct: 146 ALEGQMFRKTGRLISLSEQNLVDCSGPQGNEGCNGGLMDYAFQYVQDNGGLDSEESYPYE 205
Query: 582 AKQGNCVFDKSKVVANCKGFQNINSCNEKDLAVAVATVGPISVAIDVGY-SFQQYKQGVY 758
A + +C ++ VAN GF +I EK L AVATVGPISVAID G+ SF YK+G+Y
Sbjct: 206 ATEESCKYNPKYSVANDTGFVDIPK-QEKALMKAVATVGPISVAIDAGHESFLFYKEGIY 264
Query: 759 YEAKCDPTIQNHAVLVVG 812
+E C +H VLVVG
Sbjct: 265 FEPDCSSEDMDHGVLVVG 282
Database: Non-redundant SwissProt sequences
Posted date: Dec 6, 2005 7:40 AM
Number of letters in database: 68,354,980
Number of sequences in database: 184,735
Database: swissprot.01
Posted date: Dec 6, 2005 8:18 AM
Number of letters in database: 66,202,850
Number of sequences in database: 184,431
Lambda K H
0.318 0.134 0.401
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 93,211,457
Number of Sequences: 369166
Number of extensions: 1928633
Number of successful extensions: 5932
Number of sequences better than 10.0: 10
Number of HSP's better than 10.0 without gapping: 5216
Number of HSP's successfully gapped in prelim test: 0
Number of HSP's that attempted gapping in prelim test: 0
Number of HSP's gapped (non-prelim): 5468
length of database: 68,354,980
effective HSP length: 109
effective length of database: 48,218,865
effective search space used: 7763237265
frameshift window, decay const: 40, 0.1
T: 12
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)