Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= Dr_sW_007_G05
(907 letters)
Database: Non-redundant SwissProt sequences
184,735 sequences; 68,354,980 total letters
Score E
Sequences producing significant alignments: (bits) Value
sp|P43090|HEM0_OPSTA 5-aminolevulinate synthase, erythroid-... 293 6e-79
sp|Q9YHT4|HEM0_BRARE 5-aminolevulinate synthase, erythroid-... 289 7e-78
sp|Q9XT75|HEM0_DELLE 5-aminolevulinate synthase, erythroid-... 286 4e-77
sp|P22557|HEM0_HUMAN 5-aminolevulinate synthase, erythroid-... 285 2e-76
sp|P08680|HEM0_MOUSE 5-aminolevulinate synthase, erythroid-... 283 5e-76
sp|Q63147|HEM0_RAT 5-aminolevulinate synthase, erythroid-sp... 283 5e-76
sp|Q8VC19|HEM1_MOUSE 5-aminolevulinate synthase, nonspecifi... 279 9e-75
sp|P13196|HEM1_HUMAN 5-aminolevulinate synthase, nonspecifi... 278 1e-74
sp|Q9XS79|HEM1_DELLE 5-aminolevulinate synthase, nonspecifi... 278 1e-74
sp|P13195|HEM1_RAT 5-aminolevulinate synthase, nonspecific,... 277 3e-74
>sp|P43090|HEM0_OPSTA 5-aminolevulinate synthase, erythroid-specific, mitochondrial
precursor (5-aminolevulinic acid synthase)
(Delta-aminolevulinate synthase) (Delta-ALA synthetase)
(ALAS-E)
Length = 582
Score = 293 bits (749), Expect = 6e-79
Identities = 141/237 (59%), Positives = 182/237 (76%)
Frame = +2
Query: 2 DSRHLDQLLSKIATDIPKLVAFETVHSMSGNICPVDDLLDVCEKHGAFSFVDEVHAVGLY 181
DSRHL++LL + PK+VAFETVHSM G ICP+++L DV +HGA +FVDEVHAVGLY
Sbjct: 301 DSRHLEELLQQSDPKTPKIVAFETVHSMDGAICPLEELCDVAHRHGALTFVDEVHAVGLY 360
Query: 182 GDHGAGVAERDGVMDRIDIISGTLGKAFGNVGGYIAGDKAVVDMIRNYASGFIFTTSLPP 361
G HGAGV ERD VM +IDI+SGTLGKAFG VGGY+A A+VD +R++A+GFIFTTSLPP
Sbjct: 361 GAHGAGVGERDNVMHKIDIVSGTLGKAFGCVGGYVASSAALVDTVRSFAAGFIFTTSLPP 420
Query: 362 HVLAGARKSVDILASDEGRELRAKHQSVVRTVKSYLQQEGIPVVDCPSHIIPVHVGHPGL 541
+LAGA +SV +L S EG+ LR HQ V+ ++ L +G+PVV+CPSHIIP+ VG+ L
Sbjct: 421 MILAGALESVRVLKSPEGQLLRRAHQRNVKYMRQLLMDKGLPVVNCPSHIIPIRVGNAEL 480
Query: 542 CTHLSNELLQKYSIYVQAINHPTVAFGEERLRIAPSPHHTLPMINELVSALTDLWKE 712
T + + LL+K++IYVQAIN+PTV G+E LR+APSPHH M+ V L ++W+E
Sbjct: 481 NTKVCDSLLEKHNIYVQAINYPTVPRGQELLRLAPSPHHHPAMMEYFVDKLVEVWQE 537
>sp|Q9YHT4|HEM0_BRARE 5-aminolevulinate synthase, erythroid-specific, mitochondrial
precursor (5-aminolevulinic acid synthase)
(Delta-aminolevulinate synthase) (Delta-ALA synthetase)
(ALAS-E)
Length = 583
Score = 289 bits (740), Expect = 7e-78
Identities = 144/241 (59%), Positives = 182/241 (75%)
Frame = +2
Query: 2 DSRHLDQLLSKIATDIPKLVAFETVHSMSGNICPVDDLLDVCEKHGAFSFVDEVHAVGLY 181
D+ HL++LLS+ PK+VAFETVHSM G ICP+++L DV K+GA +FVDEVHAVGLY
Sbjct: 301 DASHLEELLSRSDPLTPKIVAFETVHSMDGAICPLEELCDVAHKYGALTFVDEVHAVGLY 360
Query: 182 GDHGAGVAERDGVMDRIDIISGTLGKAFGNVGGYIAGDKAVVDMIRNYASGFIFTTSLPP 361
G HGAGV ERD VM +IDI+SGTLGKAFG VGGYIA A+VD +R++A+GFIFTTSLPP
Sbjct: 361 GAHGAGVGERDNVMHKIDIVSGTLGKAFGCVGGYIASTAALVDTVRSFAAGFIFTTSLPP 420
Query: 362 HVLAGARKSVDILASDEGRELRAKHQSVVRTVKSYLQQEGIPVVDCPSHIIPVHVGHPGL 541
VLAGA +SV +L SDEG+ LR HQ V+ ++ L G+PVV+CPSHIIP+ VG+
Sbjct: 421 MVLAGALESVRVLKSDEGQALRRAHQRNVKHMRQLLLDAGLPVVNCPSHIIPIRVGNAAK 480
Query: 542 CTHLSNELLQKYSIYVQAINHPTVAFGEERLRIAPSPHHTLPMINELVSALTDLWKENKL 721
+ + + LL+K++IYVQAIN+PTV GEE LR+APSP H M+N L D+W+E L
Sbjct: 481 NSEVCDILLEKHNIYVQAINYPTVPRGEELLRLAPSPFHNPIMMNYFAEKLLDVWQEVGL 540
Query: 722 P 724
P
Sbjct: 541 P 541
>sp|Q9XT75|HEM0_DELLE 5-aminolevulinate synthase, erythroid-specific, mitochondrial
precursor (5-aminolevulinic acid synthase)
(Delta-aminolevulinate synthase) (Delta-ALA synthetase)
(ALAS-E)
Length = 582
Score = 286 bits (733), Expect = 4e-77
Identities = 140/247 (56%), Positives = 180/247 (72%)
Frame = +2
Query: 2 DSRHLDQLLSKIATDIPKLVAFETVHSMSGNICPVDDLLDVCEKHGAFSFVDEVHAVGLY 181
D HL +LL K + PK+VAFETVHSM G ICP+++L DV ++GA +FVDEVHAVGLY
Sbjct: 301 DPDHLKKLLKKSNPETPKIVAFETVHSMDGAICPLEELCDVAHQYGALTFVDEVHAVGLY 360
Query: 182 GDHGAGVAERDGVMDRIDIISGTLGKAFGNVGGYIAGDKAVVDMIRNYASGFIFTTSLPP 361
G GAG+ ERDG+M +IDIISGTLGKAFG VGGYIA + +VDM+R+YA+GFIFTTSLPP
Sbjct: 361 GSRGAGIGERDGIMHKIDIISGTLGKAFGCVGGYIASTRDLVDMVRSYAAGFIFTTSLPP 420
Query: 362 HVLAGARKSVDILASDEGRELRAKHQSVVRTVKSYLQQEGIPVVDCPSHIIPVHVGHPGL 541
VL+GA +SV +L +EG+ LR HQ V+ ++ L G+PV+ CPSHIIP+ VG L
Sbjct: 421 MVLSGALESVRLLKGEEGQALRRAHQRNVKHMRQLLMDRGLPVIPCPSHIIPIRVGDAAL 480
Query: 542 CTHLSNELLQKYSIYVQAINHPTVAFGEERLRIAPSPHHTLPMINELVSALTDLWKENKL 721
+ + + LL K+ IYVQAIN+PTV GEE LR+APSPHH+ M+ + V L W E L
Sbjct: 481 NSRICDLLLSKHGIYVQAINYPTVPRGEELLRLAPSPHHSPQMMEDFVEKLLAAWTEVGL 540
Query: 722 PFYNQNL 742
P + ++
Sbjct: 541 PLQDVSI 547
>sp|P22557|HEM0_HUMAN 5-aminolevulinate synthase, erythroid-specific, mitochondrial
precursor (5-aminolevulinic acid synthase)
(Delta-aminolevulinate synthase) (Delta-ALA synthetase)
(ALAS-E)
Length = 587
Score = 285 bits (728), Expect = 2e-76
Identities = 141/241 (58%), Positives = 177/241 (73%)
Frame = +2
Query: 2 DSRHLDQLLSKIATDIPKLVAFETVHSMSGNICPVDDLLDVCEKHGAFSFVDEVHAVGLY 181
D HL +LL K IPK+VAFETVHSM G ICP+++L DV ++GA +FVDEVHAVGLY
Sbjct: 306 DPDHLKKLLEKSNPKIPKIVAFETVHSMDGAICPLEELCDVSHQYGALTFVDEVHAVGLY 365
Query: 182 GDHGAGVAERDGVMDRIDIISGTLGKAFGNVGGYIAGDKAVVDMIRNYASGFIFTTSLPP 361
G GAG+ ERDG+M +IDIISGTLGKAFG VGGYIA + +VDM+R+YA+GFIFTTSLPP
Sbjct: 366 GSRGAGIGERDGIMHKIDIISGTLGKAFGCVGGYIASTRDLVDMVRSYAAGFIFTTSLPP 425
Query: 362 HVLAGARKSVDILASDEGRELRAKHQSVVRTVKSYLQQEGIPVVDCPSHIIPVHVGHPGL 541
VL+GA +SV +L +EG+ LR HQ V+ ++ L G+PV+ CPSHIIP+ VG+ L
Sbjct: 426 MVLSGALESVRLLKGEEGQALRRAHQRNVKHMRQLLMDRGLPVIPCPSHIIPIRVGNAAL 485
Query: 542 CTHLSNELLQKYSIYVQAINHPTVAFGEERLRIAPSPHHTLPMINELVSALTDLWKENKL 721
+ L + LL K+ IYVQAIN+PTV GEE LR+APSPHH+ M+ + V L W L
Sbjct: 486 NSKLCDLLLSKHGIYVQAINYPTVPRGEELLRLAPSPHHSPQMMEDFVEKLLLAWTAVGL 545
Query: 722 P 724
P
Sbjct: 546 P 546
>sp|P08680|HEM0_MOUSE 5-aminolevulinate synthase, erythroid-specific, mitochondrial
precursor (5-aminolevulinic acid synthase)
(Delta-aminolevulinate synthase) (Delta-ALA synthetase)
(ALAS-E)
Length = 587
Score = 283 bits (724), Expect = 5e-76
Identities = 140/241 (58%), Positives = 176/241 (73%)
Frame = +2
Query: 2 DSRHLDQLLSKIATDIPKLVAFETVHSMSGNICPVDDLLDVCEKHGAFSFVDEVHAVGLY 181
D HL +LL K PK+VAFETVHSM G ICP+++L DV ++GA +FVDEVHAVGLY
Sbjct: 306 DPGHLKKLLEKSDPKTPKIVAFETVHSMDGAICPLEELCDVAHQYGALTFVDEVHAVGLY 365
Query: 182 GDHGAGVAERDGVMDRIDIISGTLGKAFGNVGGYIAGDKAVVDMIRNYASGFIFTTSLPP 361
G GAG+ ERDG+M ++DIISGTLGKAFG VGGYIA + +VDM+R+YA+GFIFTTSLPP
Sbjct: 366 GARGAGIGERDGIMHKLDIISGTLGKAFGCVGGYIASTRDLVDMVRSYAAGFIFTTSLPP 425
Query: 362 HVLAGARKSVDILASDEGRELRAKHQSVVRTVKSYLQQEGIPVVDCPSHIIPVHVGHPGL 541
VL+GA +SV +L +EG+ LR HQ V+ ++ L G PV+ CPSHIIP+ VG+ L
Sbjct: 426 MVLSGALESVRLLKGEEGQALRRAHQRNVKHMRQLLMDRGFPVIPCPSHIIPIRVGNAAL 485
Query: 542 CTHLSNELLQKYSIYVQAINHPTVAFGEERLRIAPSPHHTLPMINELVSALTDLWKENKL 721
+ + + LL K+SIYVQAIN+PTV GEE LR+APSPHH+ M+ V L W E L
Sbjct: 486 NSKICDLLLSKHSIYVQAINYPTVPRGEELLRLAPSPHHSPQMMENFVEKLLLAWTEVGL 545
Query: 722 P 724
P
Sbjct: 546 P 546
>sp|Q63147|HEM0_RAT 5-aminolevulinate synthase, erythroid-specific, mitochondrial
precursor (5-aminolevulinic acid synthase)
(Delta-aminolevulinate synthase) (Delta-ALA synthetase)
(ALAS-E)
Length = 587
Score = 283 bits (724), Expect = 5e-76
Identities = 140/241 (58%), Positives = 176/241 (73%)
Frame = +2
Query: 2 DSRHLDQLLSKIATDIPKLVAFETVHSMSGNICPVDDLLDVCEKHGAFSFVDEVHAVGLY 181
D HL +LL K PK+VAFETVHSM G ICP+++L DV ++GA +FVDEVHAVGLY
Sbjct: 306 DPGHLKKLLEKSDPKTPKIVAFETVHSMDGAICPLEELCDVAHQYGALTFVDEVHAVGLY 365
Query: 182 GDHGAGVAERDGVMDRIDIISGTLGKAFGNVGGYIAGDKAVVDMIRNYASGFIFTTSLPP 361
G GAG+ ERDG+M ++DIISGTLGKAFG VGGYIA + +VDM+R+YA+GFIFTTSLPP
Sbjct: 366 GTRGAGIGERDGIMHKLDIISGTLGKAFGCVGGYIASTRDLVDMVRSYAAGFIFTTSLPP 425
Query: 362 HVLAGARKSVDILASDEGRELRAKHQSVVRTVKSYLQQEGIPVVDCPSHIIPVHVGHPGL 541
VL+GA +SV +L +EG+ LR HQ V+ ++ L G PV+ CPSHIIP+ VG+ L
Sbjct: 426 MVLSGALESVRLLKGEEGQALRRAHQRNVKHMRQLLMDRGFPVIPCPSHIIPIRVGNAAL 485
Query: 542 CTHLSNELLQKYSIYVQAINHPTVAFGEERLRIAPSPHHTLPMINELVSALTDLWKENKL 721
+ + + LL K+SIYVQAIN+PTV GEE LR+APSPHH+ M+ V L W E L
Sbjct: 486 NSKICDLLLAKHSIYVQAINYPTVPRGEELLRLAPSPHHSPQMMENFVEKLLLAWTEVGL 545
Query: 722 P 724
P
Sbjct: 546 P 546
>sp|Q8VC19|HEM1_MOUSE 5-aminolevulinate synthase, nonspecific, mitochondrial precursor
(5-aminolevulinic acid synthase) (Delta-aminolevulinate
synthase) (Delta-ALA synthetase) (ALAS-H)
Length = 642
Score = 279 bits (713), Expect = 9e-75
Identities = 136/236 (57%), Positives = 172/236 (72%)
Frame = +2
Query: 2 DSRHLDQLLSKIATDIPKLVAFETVHSMSGNICPVDDLLDVCEKHGAFSFVDEVHAVGLY 181
D HL +LL + +PK+VAFETVHSM G +CP+++L DV + GA +FVDEVHAVGLY
Sbjct: 362 DVNHLRELLQRSDPSVPKIVAFETVHSMDGAVCPLEELCDVAHEFGAITFVDEVHAVGLY 421
Query: 182 GDHGAGVAERDGVMDRIDIISGTLGKAFGNVGGYIAGDKAVVDMIRNYASGFIFTTSLPP 361
G G G+ +RDGVM ++DIISGTLGKAFG VGGYIA ++D +R+YA+GFIFTTSLPP
Sbjct: 422 GARGGGIGDRDGVMPKMDIISGTLGKAFGCVGGYIASTSLLIDTVRSYAAGFIFTTSLPP 481
Query: 362 HVLAGARKSVDILASDEGRELRAKHQSVVRTVKSYLQQEGIPVVDCPSHIIPVHVGHPGL 541
+LAGA +SV IL S EGR LR +HQ V+ ++ L G+PV+ CPSHIIPV V
Sbjct: 482 MLLAGALESVRILKSSEGRALRRQHQRNVKLLRQMLMDAGLPVIHCPSHIIPVRVADAAK 541
Query: 542 CTHLSNELLQKYSIYVQAINHPTVAFGEERLRIAPSPHHTLPMINELVSALTDLWK 709
T + +EL+ +++IYVQAIN+PTV GEE LRIAP+PHHT M+N V L WK
Sbjct: 542 NTEICDELMTRHNIYVQAINYPTVPRGEELLRIAPTPHHTPQMMNFFVEKLLVTWK 597
>sp|P13196|HEM1_HUMAN 5-aminolevulinate synthase, nonspecific, mitochondrial precursor
(5-aminolevulinic acid synthase) (Delta-aminolevulinate
synthase) (Delta-ALA synthetase) (ALAS-H)
Length = 640
Score = 278 bits (711), Expect = 1e-74
Identities = 136/237 (57%), Positives = 174/237 (73%)
Frame = +2
Query: 2 DSRHLDQLLSKIATDIPKLVAFETVHSMSGNICPVDDLLDVCEKHGAFSFVDEVHAVGLY 181
D HL +LL + +PK+VAFETVHSM G +CP+++L DV + GA +FVDEVHAVGLY
Sbjct: 360 DVSHLRELLQRSDPSVPKIVAFETVHSMDGAVCPLEELCDVAHEFGAITFVDEVHAVGLY 419
Query: 182 GDHGAGVAERDGVMDRIDIISGTLGKAFGNVGGYIAGDKAVVDMIRNYASGFIFTTSLPP 361
G G G+ +RDGVM ++DIISGTLGKAFG VGGYIA +++D +R+YA+GFIFTTSLPP
Sbjct: 420 GARGGGIGDRDGVMPKMDIISGTLGKAFGCVGGYIASTSSLIDTVRSYAAGFIFTTSLPP 479
Query: 362 HVLAGARKSVDILASDEGRELRAKHQSVVRTVKSYLQQEGIPVVDCPSHIIPVHVGHPGL 541
+LAGA +SV IL S EGR LR +HQ V+ ++ L G+PVV CPSHIIPV V
Sbjct: 480 MLLAGALESVRILKSAEGRVLRRQHQRNVKLMRQMLMDAGLPVVHCPSHIIPVRVADAAK 539
Query: 542 CTHLSNELLQKYSIYVQAINHPTVAFGEERLRIAPSPHHTLPMINELVSALTDLWKE 712
T + +EL+ +++IYVQAIN+PTV GEE LRIAP+PHHT M+N + L WK+
Sbjct: 540 NTEVCDELMSRHNIYVQAINYPTVPRGEELLRIAPTPHHTPQMMNYFLENLLVTWKQ 596
>sp|Q9XS79|HEM1_DELLE 5-aminolevulinate synthase, nonspecific, mitochondrial precursor
(5-aminolevulinic acid synthase) (Delta-aminolevulinate
synthase) (Delta-ALA synthetase) (ALAS-H)
Length = 640
Score = 278 bits (711), Expect = 1e-74
Identities = 138/236 (58%), Positives = 172/236 (72%)
Frame = +2
Query: 2 DSRHLDQLLSKIATDIPKLVAFETVHSMSGNICPVDDLLDVCEKHGAFSFVDEVHAVGLY 181
D HL +LL + +PK+VAFETVHSM G +CP+++L DV + GA +FVDEVHAVGLY
Sbjct: 360 DVDHLRELLQRSDPAVPKIVAFETVHSMDGAVCPLEELCDVAHEFGAITFVDEVHAVGLY 419
Query: 182 GDHGAGVAERDGVMDRIDIISGTLGKAFGNVGGYIAGDKAVVDMIRNYASGFIFTTSLPP 361
G G G+ +RDGVM ++DIISGTLGKAFG VGGYIA +++D IR+YA+GFIFTTSLPP
Sbjct: 420 GAQGGGIGDRDGVMPKMDIISGTLGKAFGCVGGYIASTSSLIDTIRSYAAGFIFTTSLPP 479
Query: 362 HVLAGARKSVDILASDEGRELRAKHQSVVRTVKSYLQQEGIPVVDCPSHIIPVHVGHPGL 541
+LAGA +SV IL S EGR LR +HQ V+ ++ L +PVV CPSHIIPV V
Sbjct: 480 MLLAGALESVRILKSTEGRVLRRQHQRNVKLMRQMLMDASLPVVHCPSHIIPVRVADAAK 539
Query: 542 CTHLSNELLQKYSIYVQAINHPTVAFGEERLRIAPSPHHTLPMINELVSALTDLWK 709
T + NEL+ +++IYVQAIN+PTV GEE LRIAP+PHHT M+N V L WK
Sbjct: 540 NTEVCNELMSRHNIYVQAINYPTVRRGEELLRIAPTPHHTPQMMNYFVENLLATWK 595
>sp|P13195|HEM1_RAT 5-aminolevulinate synthase, nonspecific, mitochondrial precursor
(5-aminolevulinic acid synthase) (Delta-aminolevulinate
synthase) (Delta-ALA synthetase) (ALAS-H)
Length = 642
Score = 277 bits (709), Expect = 3e-74
Identities = 135/236 (57%), Positives = 173/236 (73%)
Frame = +2
Query: 2 DSRHLDQLLSKIATDIPKLVAFETVHSMSGNICPVDDLLDVCEKHGAFSFVDEVHAVGLY 181
D HL +LL + +PK+VAFETVHSM G +CP+++L DV + GA +FVDEVHAVGLY
Sbjct: 362 DVNHLRELLQRSDPSVPKIVAFETVHSMDGAVCPLEELCDVAHEFGAITFVDEVHAVGLY 421
Query: 182 GDHGAGVAERDGVMDRIDIISGTLGKAFGNVGGYIAGDKAVVDMIRNYASGFIFTTSLPP 361
G G G+ +RDGVM ++DIISGTLGKAFG VGGYIA ++D +R+YA+GFIFTTSLPP
Sbjct: 422 GASGGGIGDRDGVMPKMDIISGTLGKAFGCVGGYIASTSLLIDTVRSYAAGFIFTTSLPP 481
Query: 362 HVLAGARKSVDILASDEGRELRAKHQSVVRTVKSYLQQEGIPVVDCPSHIIPVHVGHPGL 541
+LAGA +SV IL S+EGR LR +HQ V+ ++ L G+PV+ CPSHIIPV V
Sbjct: 482 MLLAGALESVRILKSNEGRALRRQHQRNVKLMRQMLMDAGLPVIHCPSHIIPVRVADAAK 541
Query: 542 CTHLSNELLQKYSIYVQAINHPTVAFGEERLRIAPSPHHTLPMINELVSALTDLWK 709
T + +EL+ +++IYVQAIN+PTV GEE LRIAP+PHHT M+N + L WK
Sbjct: 542 NTEICDELMTRHNIYVQAINYPTVPRGEELLRIAPTPHHTPQMMNFFLEKLLLTWK 597
Database: Non-redundant SwissProt sequences
Posted date: Dec 6, 2005 7:40 AM
Number of letters in database: 68,354,980
Number of sequences in database: 184,735
Database: swissprot.01
Posted date: Dec 6, 2005 8:18 AM
Number of letters in database: 66,202,850
Number of sequences in database: 184,431
Lambda K H
0.318 0.134 0.401
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 105,803,023
Number of Sequences: 369166
Number of extensions: 2274827
Number of successful extensions: 8190
Number of sequences better than 10.0: 10
Number of HSP's better than 10.0 without gapping: 7409
Number of HSP's successfully gapped in prelim test: 0
Number of HSP's that attempted gapping in prelim test: 0
Number of HSP's gapped (non-prelim): 8032
length of database: 68,354,980
effective HSP length: 110
effective length of database: 48,034,130
effective search space used: 9174518830
frameshift window, decay const: 40, 0.1
T: 12
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)