Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= Dr_sW_007_F05
(901 letters)
Database: Non-redundant SwissProt sequences
184,735 sequences; 68,354,980 total letters
Score E
Sequences producing significant alignments: (bits) Value
sp|P87169|MAD1_SCHPO Spindle assembly checkpoint component ... 51 5e-06
sp|Q15075|EEA1_HUMAN Early endosome antigen 1 (Endosome-ass... 50 9e-06
sp|P25386|USO1_YEAST Intracellular protein transport protei... 49 2e-05
sp|Q60563|SYCP1_MESAU Synaptonemal complex protein 1 (SCP-1... 49 2e-05
sp|Q97WH0|RAD50_SULSO DNA double-strand break repair rad50 ... 48 4e-05
sp|P32380|NUF1_YEAST Protein NUF1 (Spindle poly body spacer... 47 9e-05
sp|Q4V328|GRAP1_HUMAN GRIP1-associated protein 1 (GRASP-1) 46 2e-04
sp|Q59037|SMC_METJA Chromosome partition protein smc homolog 45 3e-04
sp|Q7Z3E2|CJ118_HUMAN Protein C10orf118 (CTCL tumor antigen... 44 5e-04
sp|O33600|RAD50_SULAC DNA double-strand break repair rad50 ... 44 6e-04
>sp|P87169|MAD1_SCHPO Spindle assembly checkpoint component mad1 (Mitotic arrest
deficient protein 1)
Length = 689
Score = 50.8 bits (120), Expect = 5e-06
Identities = 54/254 (21%), Positives = 119/254 (46%), Gaps = 10/254 (3%)
Frame = +1
Query: 67 KEIEDQISNHNAQIETLKNEFDAXXXXXXXXXXXXXXXRINELKKTHEKEMETIKEEANK 246
K++E+Q +++ +IE ++NE +A +I+EL KE+ +K + K
Sbjct: 108 KQLEEQSTSYQKEIEEVRNEKEA------------TQVKIHELLDAKWKEIAELKTQIEK 155
Query: 247 MEIELTNRIRELVENNE--KFKVSSETKLSETVIDYECKLNEKQMELEASELKYQDXXXX 420
+ L+ + E++ +N+ + K ++ T L + D +L K EL A+E + Q+
Sbjct: 156 NDQALSEKNHEVMVSNQALQMKDTNLTNLEKLFADSREQLETKCKELAAAEQQLQELSVH 215
Query: 421 XXXXXXXXXXXXDYAQEELKVVNKKNQRMLKDVKK----QLEKEVKLTQETQSRLEEVVS 588
+ EL+ +N + + + +++K Q E+ KL+ + +R E++
Sbjct: 216 NQQLEESIKQVS--SSIELEKINAEQRLQISELEKLKAAQEERIEKLS--SNNRNVEILK 271
Query: 589 SGSQNSQTKI---NEYLSGV-SFKMANNDDQSSLYSSQNNGIDNCPMSPSISNSIAVTDD 756
+ ++K+ EY V + ++ N Q+ L S ++ + P ++SN + +
Sbjct: 272 EEKNDLESKLYRFEEYRDKVATLELENEKIQTELNSWKSLITNELPTPEAVSNKLVFLQN 331
Query: 757 ELKNLLDRFTSVQN 798
NL +R +S+++
Sbjct: 332 TNANLGERVSSLES 345
>sp|Q15075|EEA1_HUMAN Early endosome antigen 1 (Endosome-associated protein p162) (Zinc
finger FYVE domain-containing protein 2)
Length = 1411
Score = 50.1 bits (118), Expect = 9e-06
Identities = 53/249 (21%), Positives = 107/249 (42%), Gaps = 17/249 (6%)
Frame = +1
Query: 190 ELKKTHEKEMETIKEEANKMEIELTNRIRELVENNEKFKVSSETKLSE--TVIDYECKLN 363
E K+ +++ ET+ +E EL NRI+ V +K K+ E ++E TV D KL+
Sbjct: 807 EEKQILKQDFETLSQETKIQHEELNNRIQTTVTELQKVKMEKEALMTELSTVKD---KLS 863
Query: 364 EKQMELEASELKYQDXXXXXXXXXXXXXXXXDYAQEELKVVNKKNQRMLKDVKKQLEKEV 543
+ L+ S+ +++ + +L+V + + K++KK LEKE
Sbjct: 864 KVSDSLKNSKSEFEKENQKGKAAILDLEKTCKELKHQLQVQMENTLKEQKELKKSLEKEK 923
Query: 544 ----KLTQETQSRLEEVVSSGSQNSQT-KINEYLSGVSFKMANNDDQSSLYSSQNNG--- 699
+L E S E+++ + + Q K + L G ++ + +Q G
Sbjct: 924 EASHQLKLELNSMQEQLIQAQNTLKQNEKEEQQLQGNINELKQSSEQKKKQIEALQGELK 983
Query: 700 ---IDNCPMSPSISNSIAVTDDELKNLLDRFTSVQNDFGESKRLIESLNHD----KSELI 858
+ + + + EL ++ + +QN++ +S+ + L D +SEL+
Sbjct: 984 IAVLQKTELENKLQQQLTQAAQELAAEKEKISVLQNNYEKSQETFKQLQSDFYGRESELL 1043
Query: 859 KTIEGQQSI 885
T + +S+
Sbjct: 1044 ATRQDLKSV 1052
Score = 33.9 bits (76), Expect = 0.64
Identities = 52/226 (23%), Positives = 97/226 (42%), Gaps = 9/226 (3%)
Frame = +1
Query: 211 KEMETIKEEANKMEIELTNRIRELVENNEKFKVSSETKLSETVIDYECKLNEKQMELEAS 390
K ++ I++E + E EL N +L E E+ K E ++ T ++ E K ++ + E +
Sbjct: 1103 KALQDIQKEKSLKEKELVNEKSKLAEI-EEIKCRQEKEI--TKLNEELKSHKLESIKEIT 1159
Query: 391 ELKYQDXXXXXXXXXXXXXXXXDYAQEELKVVNKKNQRMLKD-VKKQ--------LEKEV 543
LK D D + ++ K+NQ++LKD VKK+ +EKE
Sbjct: 1160 NLK--DAKQLLIQQKLELQGKADSLKAAVEQ-EKRNQQILKDQVKKEEEELKKEFIEKEA 1216
Query: 544 KLTQETQSRLEEVVSSGSQNSQTKINEYLSGVSFKMANNDDQSSLYSSQNNGIDNCPMSP 723
KL E + + EV + ++ K+ ++ ++ + + SSQ + +
Sbjct: 1217 KLHSEIKEK--EVGMKKHEENEAKLTMQITALNENLGT--VKKEWQSSQRRVSELEKQTD 1272
Query: 724 SISNSIAVTDDELKNLLDRFTSVQNDFGESKRLIESLNHDKSELIK 861
+ IAV + +VQN+ E + L+E + E+ K
Sbjct: 1273 DLRGEIAVLE----------ATVQNNQDERRALLERCLKGEGEIEK 1308
Score = 32.3 bits (72), Expect = 1.9
Identities = 45/236 (19%), Positives = 94/236 (39%), Gaps = 21/236 (8%)
Frame = +1
Query: 184 INELKKTHEKEMETIKEEANKMEIELTNRIRELVEN-----NEKFKVSSETKLSETVIDY 348
I E+K EKE+ + EE ++E I L + +K ++ + + ++
Sbjct: 1129 IEEIKCRQEKEITKLNEELKSHKLESIKEITNLKDAKQLLIQQKLELQGKADSLKAAVEQ 1188
Query: 349 ECKLNEK----QMELEASELKYQDXXXXXXXXXXXXXXXXDYAQEELKVVNKKNQRMLKD 516
E K N++ Q++ E ELK ++ ++E K+ ++ ++ +
Sbjct: 1189 E-KRNQQILKDQVKKEEEELK------------------KEFIEKEAKLHSEIKEKEV-G 1228
Query: 517 VKKQLEKEVKLTQETQSRLEEV--VSSGSQNSQTKINEY----------LSGVSFKMANN 660
+KK E E KLT + + E + V Q+SQ +++E ++ + + NN
Sbjct: 1229 MKKHEENEAKLTMQITALNENLGTVKKEWQSSQRRVSELEKQTDDLRGEIAVLEATVQNN 1288
Query: 661 DDQSSLYSSQNNGIDNCPMSPSISNSIAVTDDELKNLLDRFTSVQNDFGESKRLIE 828
D+ ++ C + EL+ LD T+ + G + ++
Sbjct: 1289 QDERRAL------LERCLKGEGEIEKLQTKVLELQRKLDNTTAAVQELGRENQSLQ 1338
>sp|P25386|USO1_YEAST Intracellular protein transport protein USO1 (Int-1)
Length = 1790
Score = 48.9 bits (115), Expect = 2e-05
Identities = 68/295 (23%), Positives = 127/295 (43%), Gaps = 6/295 (2%)
Frame = +1
Query: 34 KEIDFLNLNHSKEIEDQISNHNAQIETLKNEFDAXXXXXXXXXXXXXXXR--INELKKTH 207
K++ N + K +E+ + + Q+ L+N+ D+ I +LKKT
Sbjct: 972 KDMQAENESLIKAVEESKNESSIQLSNLQNKIDSMSQEKENFQIERGSIEKNIEQLKKTI 1031
Query: 208 ---EKEMETIKEEANKMEIELTNRIRELVENNEKFKVSSETKLSETVIDYECKLNEKQME 378
E+ E I +++ + E ++I L E K+ + T ++ ++ +L + + E
Sbjct: 1032 SDLEQTKEEIISKSDSSKDEYESQISLLKE-----KLETATTANDENVNKISELTKTREE 1086
Query: 379 LEASELKYQDXXXXXXXXXXXXXXXXDYAQEELKVVNKKNQRMLKDVKKQLEKEVKLTQE 558
LEA Y++ + +++ LK V K+N+ LK+ K QLEKE T++
Sbjct: 1087 LEAELAAYKNLKNELETKL-------ETSEKALKEV-KENEEHLKEEKIQLEKEATETKQ 1138
Query: 559 TQSRLEEVVSSGSQNSQTKINEYLSGVSFKMANNDDQSSLYSSQNNGIDNCPMSPSISNS 738
+ L + S + + L ++AN + Q + SQ N D + + S
Sbjct: 1139 QLNSLRANLES-LEKEHEDLAAQLKKYEEQIANKERQYNEEISQLN--DEITSTQQENES 1195
Query: 739 IAVTDDELKNLLDRFTSVQNDFGESKRL-IESLNHDKSELIKTIEGQQSIILNYI 900
I +DEL+ + S + K+ I++LN EL K E ++ +L I
Sbjct: 1196 IKKKNDELEGEVKAMKSTSEEQSNLKKSEIDALNLQIKELKKKNETNEASLLESI 1250
Score = 46.2 bits (108), Expect = 1e-04
Identities = 59/312 (18%), Positives = 125/312 (40%), Gaps = 14/312 (4%)
Frame = +1
Query: 4 KLTNKHAMVEKEIDFLNLNHSKEIEDQISNHNAQIETLKNEFDAXXXXXXXXXXXXXXXR 183
++ NK +EI LN D+I++ + E++K + D
Sbjct: 1167 QIANKERQYNEEISQLN--------DEITSTQQENESIKKKNDELEG------------E 1206
Query: 184 INELKKTHEKEMETIKEEANKMEIELTNRIRELVENNEKFKVSSETKLSETV----IDYE 351
+ +K T E++ K E + + +++ ++ N S ++ SETV + E
Sbjct: 1207 VKAMKSTSEEQSNLKKSEIDALNLQIKELKKKNETNEASLLESIKSVESETVKIKELQDE 1266
Query: 352 CKLNEKQMELEASELKYQDXXXXXXXXXXXXXXXXDYAQEELKVVNKKNQRMLKDVKKQL 531
C EK++ +LK + Q+E + + ++ ++K QL
Sbjct: 1267 CNFKEKEVSELEDKLKASEDKNSKYLE----------LQKESEKIKEELDAKTTELKIQL 1316
Query: 532 EKEVKLTQETQ------SRLEEVVSSGSQNSQTKINEYLSGVSFKMANNDDQSSLYSSQN 693
EK L++ + SRL++ S +N++ ++ + + + K + + L + +
Sbjct: 1317 EKITNLSKAKEKSESELSRLKKTSSEERKNAEEQLEKLKNEIQIKNQAFEKERKLLNEGS 1376
Query: 694 NGIDNCPMSPSISNSIAVTDDELKNLLDRFTSVQNDFGESKRLIESLNHDKSELIK---- 861
+ I + S I +DEL L + + ++ +E ++ EL++
Sbjct: 1377 STI-----TQEYSEKINTLEDELIRLQNENELKAKEIDNTRSELEKVSLSNDELLEEKQN 1431
Query: 862 TIEGQQSIILNY 897
TI+ Q IL+Y
Sbjct: 1432 TIKSLQDEILSY 1443
Score = 39.7 bits (91), Expect = 0.012
Identities = 55/293 (18%), Positives = 117/293 (39%), Gaps = 9/293 (3%)
Frame = +1
Query: 7 LTNKHAMVEKEIDFLNLNHSKEIEDQISNHNAQIETLKNEFDAXXXXXXXXXXXXXXXR- 183
LTN+H ++++ LN +HS +++ S +++ +++ D +
Sbjct: 767 LTNEHKELDEKYQILNSSHS-SLKENFSILETELKNVRDSLDEMTQLRDVLETKDKENQT 825
Query: 184 -INELKKTHEKEMETIKEEANKMEIELTNRIRELVENNEKFKVSSETKLSETVIDYECKL 360
+ E K T K+ ++IK +E L+ + + N+ K ++ CK
Sbjct: 826 ALLEYKSTIHKQEDSIKTLEKGLETILSQKKKAEDGINKMGKDLFALSREMQAVEENCK- 884
Query: 361 NEKQMELEASELKYQDXXXXXXXXXXXXXXXXDYAQE--ELKVVNKKNQRM---LKDVKK 525
Q E + S + +Q D A + E+K +N+ + M ++ K
Sbjct: 885 -NLQKEKDKSNVNHQ---------KETKSLKEDIAAKITEIKAINENLEEMKIQCNNLSK 934
Query: 526 QLEKEVKLTQETQSRLEEVVSSGSQNSQTKINEYLSGV--SFKMANNDDQSSLYSSQNNG 699
+ E K E +SR + N K+ E L + ++K +++S + + + +
Sbjct: 935 EKEHISKELVEYKSRFQ-----SHDNLVAKLTEKLKSLANNYKDMQAENESLIKAVEESK 989
Query: 700 IDNCPMSPSISNSIAVTDDELKNLLDRFTSVQNDFGESKRLIESLNHDKSELI 858
++ ++ N I E +N S++ + + K+ I L K E+I
Sbjct: 990 NESSIQLSNLQNKIDSMSQEKENFQIERGSIEKNIEQLKKTISDLEQTKEEII 1042
Score = 37.4 bits (85), Expect = 0.058
Identities = 60/335 (17%), Positives = 124/335 (37%), Gaps = 49/335 (14%)
Frame = +1
Query: 28 VEKEIDFLNLNHSKEIED----------QISNHNAQIETL-------------------- 117
++KE D N+NH KE + +I N +E +
Sbjct: 886 LQKEKDKSNVNHQKETKSLKEDIAAKITEIKAINENLEEMKIQCNNLSKEKEHISKELVE 945
Query: 118 -KNEFDAXXXXXXXXXXXXXXXRIN--ELKKTHEKEMETIKEEANKMEIELT---NRIRE 279
K+ F + N +++ +E ++ ++E N+ I+L+ N+I
Sbjct: 946 YKSRFQSHDNLVAKLTEKLKSLANNYKDMQAENESLIKAVEESKNESSIQLSNLQNKIDS 1005
Query: 280 LVENNEKFKVSSET------KLSETVIDYECKLNEKQMELEASELKYQDXXXXXXXXXXX 441
+ + E F++ + +L +T+ D E E + ++S+ +Y+
Sbjct: 1006 MSQEKENFQIERGSIEKNIEQLKKTISDLEQTKEEIISKSDSSKDEYESQISLLKEKLET 1065
Query: 442 XXXXXDYAQEELKVVNKKNQRMLKDVK--KQLEKEVKLTQETQSR-LEEVVSSGSQNSQT 612
D ++ + K + + ++ K L+ E++ ET + L+EV + +
Sbjct: 1066 ATTANDENVNKISELTKTREELEAELAAYKNLKNELETKLETSEKALKEVKENEEHLKEE 1125
Query: 613 KINEYLSGVSFKMANNDDQSSLYSSQNNGIDNCPM----SPSISNSIAVTDDELKNLLDR 780
KI K N +++L S + D I+N ++E+ L D
Sbjct: 1126 KIQLEKEATETKQQLNSLRANLESLEKEHEDLAAQLKKYEEQIANKERQYNEEISQLNDE 1185
Query: 781 FTSVQNDFGESKRLIESLNHDKSELIKTIEGQQSI 885
TS Q + K+ + L + + T E Q ++
Sbjct: 1186 ITSTQQENESIKKKNDELEGEVKAMKSTSEEQSNL 1220
Score = 37.0 bits (84), Expect = 0.075
Identities = 46/255 (18%), Positives = 104/255 (40%), Gaps = 30/255 (11%)
Frame = +1
Query: 181 RINELKKTHEKEMETIKEEANKMEIELTNRIRELVENNEKFKVSSE-------------T 321
++ E + E+E KE K+E + + EL + E + S E
Sbjct: 1488 KLEEESSKEKAELEKSKEMMKKLESTIESNETELKSSMETIRKSDEKLEQSKKSAEEDIK 1547
Query: 322 KLSETVIDYECKLNEKQMELEASELKYQDXXXXXXXXXXXXXXXXDYAQEELKVVNKKN- 498
L D ++NE + ++E + K + + AQE++++ ++N
Sbjct: 1548 NLQHEKSDLISRINESEKDIEELKSKLR-IEAKSGSELETVKQELNNAQEKIRINAEENT 1606
Query: 499 --QRMLKDVKKQL---EKEVKLTQETQ-------SRLEEVVSSGSQNSQTKINEYLSGV- 639
+ L+D++++L + E+K QE + LE+ + S Q +Q E + V
Sbjct: 1607 VLKSKLEDIERELKDKQAEIKSNQEEKELLTSRLKELEQELDSTQQKAQKSEEERRAEVR 1666
Query: 640 --SFKMANNDDQSSLYSSQNNGIDNCPMS-PSISNSIAVTDDELKNLLDRFTSVQNDFGE 810
+ + D+++ L ++ N + N + +++ T D + +++ ++
Sbjct: 1667 KFQVEKSQLDEKAMLLETKYNDLVNKEQAWKRDEDTVKKTTDSQRQEIEKLAKELDNLKA 1726
Query: 811 SKRLIESLNHDKSEL 855
++ N D+SE+
Sbjct: 1727 ENSKLKEANEDRSEI 1741
>sp|Q60563|SYCP1_MESAU Synaptonemal complex protein 1 (SCP-1 protein) (Meiotic chromosome
synaptic protein)
Length = 845
Score = 48.5 bits (114), Expect = 2e-05
Identities = 37/138 (26%), Positives = 73/138 (52%), Gaps = 6/138 (4%)
Frame = +1
Query: 193 LKKTHEKEMETIKEEANKMEIELTNR---IRELVENNEKFKVSSETKLSETVIDYECKLN 363
LKK EK+M+ ++ + N + + N+ I EL + N+ K S + S+ + YE K+N
Sbjct: 462 LKK--EKQMKILENKCNNLRKQAENKSKYIEELHQENKALKKKSSAE-SKQLNAYEIKVN 518
Query: 364 EKQMELEASELKYQDXXXXXXXXXXXXXXXXDYAQEELKVVNKKNQRMLKDVKK---QLE 534
+ Q+ELE+++ K+Q+ D Q+E++V +++L +V+K ++
Sbjct: 519 KLQLELESAKQKFQE--------------MTDNYQKEIEVKKISEEKLLGEVEKAKAMVD 564
Query: 535 KEVKLTQETQSRLEEVVS 588
+ VKL +E R + ++
Sbjct: 565 EAVKLQKEIDLRCQHKIA 582
Score = 44.3 bits (103), Expect = 5e-04
Identities = 48/193 (24%), Positives = 81/193 (41%), Gaps = 18/193 (9%)
Frame = +1
Query: 76 EDQISNHNAQIETLKNEFDAXXXXXXXXXXXXXXXRINELKKT---------HEKEMETI 228
EDQ+ +++ NE D ++ ELKK +K++E +
Sbjct: 255 EDQLKILTMELQKKSNELDEMTKFKNNNEV-----KLEELKKILAEDQKLLDEKKQVEKL 309
Query: 229 KEEANKMEIELT----NRIRELVENNEKFKVS--SETKLSETVIDYECKLNEKQM---EL 381
EE E ELT R +E+ + E+ V+ S+ S+ V + + KL E+++ EL
Sbjct: 310 AEELQGKEQELTLLLQTREKEVHDLEEQLLVTKISDQNYSKQVEELKTKLEEEKLKNAEL 369
Query: 382 EASELKYQDXXXXXXXXXXXXXXXXDYAQEELKVVNKKNQRMLKDVKKQLEKEVKLTQET 561
AS K QE++ K+ +RMLK ++ EKE L E
Sbjct: 370 TASCGKLSLENNKLTQETNDMALELKKYQEDITNSKKQEERMLKQIENLEEKETHLRDEL 429
Query: 562 QSRLEEVVSSGSQ 600
+S +E + G++
Sbjct: 430 ESVRKEFIQQGNE 442
>sp|Q97WH0|RAD50_SULSO DNA double-strand break repair rad50 ATPase
Length = 864
Score = 47.8 bits (112), Expect = 4e-05
Identities = 69/333 (20%), Positives = 141/333 (42%), Gaps = 48/333 (14%)
Frame = +1
Query: 16 KHAMVEKEIDFLNLNHSKE-IEDQISNHNAQIETLKNEFDAXXXXXXXXXXXXXXXRI-- 186
K + EK L L KE +ED+I N +I+ +K++FD +I
Sbjct: 189 KKTVEEKRARVLELKKDKEKLEDEIKNLEKRIKDIKDQFDEYEKKRNQYLKLTTTLKIKE 248
Query: 187 ---NELKKTHE------KEMETIKEEANKMEIELTNRIRELVENNEKFKV--SSETKLSE 333
NEL ++ E + M+ +++E N++E +R + EK++V S T++S
Sbjct: 249 GELNELNRSIEELRKQTENMDQLEKEINELE-----NLRNIKLKFEKYEVLAKSHTEMSA 303
Query: 334 TVIDYECKLNE------KQMELEASELKYQDXXXXXXXXXXXXXXXXDYAQEELKVVNKK 495
VI+ E ++ E ++ ELE LKY++ + +N K
Sbjct: 304 NVINLEKEIEEYEKAIRRKEELEPKYLKYKELERKLEELQPKYQQYLKLKSDLDSKLNLK 363
Query: 496 NQRMLKDVKK---------QLEKEVKLTQETQ-------SRLEEVVSSGSQ--NSQTKIN 621
+R+ KD + LE++V+ T++ Q +++E ++S ++ N+ +++
Sbjct: 364 -ERLEKDASELSNDIDKVNSLEQKVEETRKKQLNLRAQLAKVESLISEKNEIINNISQVE 422
Query: 622 EYLSGVSFKMANNDDQSSLYSSQNNGIDNCPMSPS--------ISNSIAVTDDELKNLLD 777
V + + + + + + I ++ + I+N + + E + L +
Sbjct: 423 GETCPVCGRPLDEEHKQKIIKEAKSYILQLELNKNELEEELKKITNELNKIEREYRRLSN 482
Query: 778 RFTSVQNDFGESKRLIESLN--HDKSELIKTIE 870
S N + K+L E + H + E +K I+
Sbjct: 483 NKASYDNVMRQLKKLNEEIENLHSEIESLKNID 515
Score = 30.8 bits (68), Expect = 5.4
Identities = 48/227 (21%), Positives = 89/227 (39%), Gaps = 15/227 (6%)
Frame = +1
Query: 241 NKMEIELTNRIRELVENNEKFKVSSETKLS-ETVIDYECKLNEK--QMELEASELKYQDX 411
N++E EL EL + +++ S K S + V+ KLNE+ + E LK D
Sbjct: 457 NELEEELKKITNELNKIEREYRRLSNNKASYDNVMRQLKKLNEEIENLHSEIESLKNIDE 516
Query: 412 XXXXXXXXXXXXXXXDYAQEELKVVNKKNQRMLKDVKKQLEKEVKLTQETQSRLEEVVSS 591
+ELK+ ++ R+ K K++L+K+ E + + EE+
Sbjct: 517 EIKKINEEV----------KELKLYYEEFMRLSKYTKEELDKKRVKLDEMKKKKEEI--- 563
Query: 592 GSQNSQTKINEYLSGVSFKMANNDDQSSLYSSQNNGIDNCPMS------PSISNSIAVTD 753
+ + L G+ K +S + +N + M + +
Sbjct: 564 --EKEMRGLESELKGLDRKAL----ESKILDLENKRVKLDEMKKKKGILEDYIRQVKLLQ 617
Query: 754 DELKNLLDRFTSVQ---NDFGESKRLIESLN---HDKSELIKTIEGQ 876
+E+KNL + +Q N + E K +++ N +K IEG+
Sbjct: 618 EEVKNLREEVNIIQFDENRYNELKTSLDAYNLSLKEKENRKSRIEGE 664
>sp|P32380|NUF1_YEAST Protein NUF1 (Spindle poly body spacer protein SPC110)
Length = 944
Score = 46.6 bits (109), Expect = 9e-05
Identities = 64/315 (20%), Positives = 135/315 (42%), Gaps = 33/315 (10%)
Frame = +1
Query: 31 EKEIDFLNLNHSKEIEDQISNHNAQIETLKNEFDAXXXXXXXXXXXXXXX------RINE 192
E E+ L N E+E++IS N+Q+ + + + R E
Sbjct: 352 ENELKMLK-NKIAELEEEISTKNSQLIAKEGKLASLMAQLTQLESKLNQRDSQLGSREEE 410
Query: 193 LKKTHEKEMETIK----EEANKME--IELTNRIRELVENNEKFKVSSETKLSETVIDYEC 354
LKKT++K + I+ E +K E I+L ++++L N+ F + S+T+ D E
Sbjct: 411 LKKTNDKLQKDIRIAREETVSKDERIIDLQKKVKQL--ENDLFVIKKTHSESKTITDNEL 468
Query: 355 KLNEK-----QMELEASELKYQDXXXXXXXXXXXXXXXXDYAQEELKVVNKKNQRMLKD- 516
+ +K + +L+ ++ KY ++E +N+K + +
Sbjct: 469 ESKDKLIKILENDLKVAQEKYSKMEKELKEREFNYKISESKLEDEKTTLNEKISNLAAEN 528
Query: 517 --VKKQLEKEVKLTQETQSRLEEVVSS----------GSQNSQTKINEYLSGVSFKMANN 660
+K ++E T + E+ + S +++S+ KI E + ++A N
Sbjct: 529 SQLKNKIEDNSTATHHMKENYEKQLESLRKDIEEYKESAKDSEDKIEE----LKIRIAEN 584
Query: 661 DDQSSLYSSQNNGIDNCPMSPSISNSIAVTDDE---LKNLLDRFTSVQNDFGESKRLIES 831
+ S S++ + +S ++ ++ + +DE LK+++DR+ + DF + K +
Sbjct: 585 SAKVSEKRSKDIKQKDEQIS-DLTQNLKLQEDEISSLKSIIDRY---KKDFNQLKSEQSN 640
Query: 832 LNHDKSELIKTIEGQ 876
+ HD + I +E +
Sbjct: 641 IQHDLNLQILNLENK 655
>sp|Q4V328|GRAP1_HUMAN GRIP1-associated protein 1 (GRASP-1)
Length = 841
Score = 45.8 bits (107), Expect = 2e-04
Identities = 51/319 (15%), Positives = 129/319 (40%), Gaps = 29/319 (9%)
Frame = +1
Query: 31 EKEIDFLNLNHSKEIEDQISNHNAQIETLKNEFDAXXXXXXXXXXXXXXXRINELKKTHE 210
++E+ + L H KE+ + + ++ L + +I E +K
Sbjct: 448 KEELGAVRLRHEKEVLGVRARYERELRELHED--------KKRQEEELRGQIRE-EKART 498
Query: 211 KEMETIKEEANKMEIELTN----------RIRELVENNEKFKVSSETKLSETVIDYECKL 360
+E+ET+++ +++ ++ + R++E E+ ++ + E L + + +L
Sbjct: 499 RELETLQQTVEELQAQVHSMDGAKGWFERRLKEAEESLQQQQQEQEEALKQCREQHAAEL 558
Query: 361 NEKQMELEASELKYQDXXXXXXXXXXXXXXXXDYAQEEL---KVVNKKNQRMLKDVKKQL 531
K+ EL+ + + ++ + +++ KK LKD+K+QL
Sbjct: 559 KGKEEELQDVRDQLEQAQEERDCHLKTISSLKQEVKDTVDGQRILEKKGSAALKDLKRQL 618
Query: 532 EKEVKLTQETQSRLEEVVSSGSQNS----------------QTKINEYLSGVSFKMANND 663
E K + Q RL++++++ S QT + +S S++ +
Sbjct: 619 HLERKRADKLQERLQDILTNSKSRSGLEELVLSEMNSPSRTQTGDSSSISSFSYREILRE 678
Query: 664 DQSSLYSSQNNGIDNCPMSPSISNSIAVTDDELKNLLDRFTSVQNDFGESKRLIESLNHD 843
+SS +++ + + P + ++D+E+ L R Q + + ++ L
Sbjct: 679 KESSAVPARS--LSSSPQAQP-PRPAELSDEEVAELFQRLAETQQEKWMLEEKVKHLEVS 735
Query: 844 KSELIKTIEGQQSIILNYI 900
+ + + + + +II Y+
Sbjct: 736 SASMAEDLCRKSAIIETYV 754
>sp|Q59037|SMC_METJA Chromosome partition protein smc homolog
Length = 1169
Score = 45.1 bits (105), Expect = 3e-04
Identities = 60/285 (21%), Positives = 124/285 (43%), Gaps = 5/285 (1%)
Frame = +1
Query: 16 KHAMVEKEIDFLNLNHSKEIEDQISNHNAQIETLKNEFDAXXXXXXXXXXXXXXXR---I 186
K+A++ K++ +LN+ + + I N +E LKNEF + I
Sbjct: 230 KYALILKKVSYLNV-----LLENIQNDIKNLEELKNEFLSKVREIDVEIENLKLRLNNII 284
Query: 187 NELKKTHEKEMETIKEEANKMEIELTNRIRELVENNEKFKVSSETKLSETVIDYECKLNE 366
NEL + +E+ + + ++E+E +EN++K SS +L + ++ E K E
Sbjct: 285 NELNEKGNEEVLELHKSIKELEVE--------IENDKKVLDSSINELKKVEVEIENKKKE 336
Query: 367 KQMELEASELKYQDXXXXXXXXXXXXXXXXDYAQEELKVVNKKNQRMLKDVKKQLEKEVK 546
+ E + ++ +D +E++K +N + +R LK+ + E +K
Sbjct: 337 IK-ETQKKIIENRDSIIEKEQQIKE-------IEEKIKNLNYEKER-LKEAIAESESIIK 387
Query: 547 LTQETQSRLEEVVSSGSQNSQTKINEYLSGVSFKMANNDDQSSLYSSQNNGID-NCPMSP 723
+E++ + + ++ +QN ++ + L +D +L + +N I+ N M
Sbjct: 388 HLKESEMEIADEIAK-NQNELYRLKKEL----------NDLDNLINRKNFEIEKNNEMIK 436
Query: 724 SISNSIAVTDD-ELKNLLDRFTSVQNDFGESKRLIESLNHDKSEL 855
+ + +D + K L ++ + SKR I+ L K EL
Sbjct: 437 KLKEELETVEDVDTKPLYLELENLNVEIEFSKRGIKELEEKKKEL 481
Score = 37.0 bits (84), Expect = 0.075
Identities = 63/320 (19%), Positives = 128/320 (40%), Gaps = 32/320 (10%)
Frame = +1
Query: 4 KLTNKHAMVEKEIDFLNLNHSKEIEDQISNHNAQIETLKNEFDAXXXXXXXXXXXXXXXR 183
++ K+ + KE++ N K+I +++ N + E + N + +
Sbjct: 732 EIAEKNTIKIKELELKN----KDILEELEELNLKREEILNRINEIES------------K 775
Query: 184 INELKKTHEKEMETIKEEANKMEIELTNRIR-EL-VENNEKFKVSSE-----TKLSETVI 342
INEL + EK + +KE + ++ N I EL + EK K+ +E T + E +I
Sbjct: 776 INELIERREKIINELKEYESDENLKRMNEIEGELKILEKEKAKLKNEIDKGLTLVKEILI 835
Query: 343 DYECKLNEKQMELEASELKYQDXXXXXXXXXXXXXXXXDYAQEELKVVNKKNQRMLKDVK 522
+LN+K EL ++ + + ++ + + KN + L + K
Sbjct: 836 PKIEELNKKVSELINKKVILEKNISFYKESIEKNLSILEEKRKRYEEL-AKNLKELTEKK 894
Query: 523 KQLEKEVKLTQETQSRLEEVVSSGSQNSQTKINEYL-SGVSFKMANNDDQSSLYSSQN-- 693
+QLEKE+ ET R + ++ + +INE + ++ +++ LY +
Sbjct: 895 EQLEKEI----ETLERERREILRKVRDIENRINELMVEKAKYESKLEEEERKLYLCEKVD 950
Query: 694 -----------------NGIDNCPMSPSISNSIAVTD-----DELKNLLDRFTSVQNDFG 807
++N S N A+ D + K L+++ + D
Sbjct: 951 VSKELEKKDIEELEIYIGELENEIKSLEPVNMRAIEDYNYVAERYKELIEKRKEYERDEK 1010
Query: 808 ESKRLIESLNHDKSELIKTI 867
+ +L+E L + K E+ +
Sbjct: 1011 KYLQLMEELENKKKEVFMEV 1030
Score = 33.9 bits (76), Expect = 0.64
Identities = 43/237 (18%), Positives = 98/237 (41%), Gaps = 3/237 (1%)
Frame = +1
Query: 187 NELKKTHEKEMETIKEEANKMEIELTNRIRELVENNEKFKVSSETKLSETVIDYECKLNE 366
+E KK E+E++ +E ++I ++ VENN K K+ E + +E I +L
Sbjct: 175 DEKKKKAEEELKKARELIEMIDIRISE-----VENNLK-KLKKEKEDAEKYIKLNEELKA 228
Query: 367 KQMELEASELKYQDXXXXXXXXXXXXXXXXDYAQEELKVVNKKNQRMLKDVKKQLEKEVK 546
+ L ++ Y + + Q ++K + + L V+ +++ E+
Sbjct: 229 AKYALILKKVSYLNVLL-------------ENIQNDIKNLEELKNEFLSKVR-EIDVEI- 273
Query: 547 LTQETQSRLEEVVSSGSQNSQTKINEYLSGVSFKMANNDDQSSLYSSQNNGIDNCPMSPS 726
+ + RL +++ ++ ++ E + ++ + S N + +
Sbjct: 274 --ENLKLRLNNIINELNEKGNEEVLELHKSIKELEVEIENDKKVLDSSINELKKVEVE-- 329
Query: 727 ISNSIAVTDDELKNLLDRFTSV---QNDFGESKRLIESLNHDKSELIKTIEGQQSII 888
I N + K +++ S+ + E + I++LN++K L + I +SII
Sbjct: 330 IENKKKEIKETQKKIIENRDSIIEKEQQIKEIEEKIKNLNYEKERLKEAIAESESII 386
>sp|Q7Z3E2|CJ118_HUMAN Protein C10orf118 (CTCL tumor antigen HD-CL-01/L14-2)
Length = 898
Score = 44.3 bits (103), Expect = 5e-04
Identities = 63/292 (21%), Positives = 115/292 (39%), Gaps = 15/292 (5%)
Frame = +1
Query: 70 EIEDQISNHNAQIETLKNEFDAXXXXXXXXXXXXXXXRINELKKT------HEKEMETIK 231
++++Q+ +IE LK E ++ IN+L+K E E+
Sbjct: 545 QLQEQLQRGKQEIENLKEEVESLNSL------------INDLQKDIEGSRKRESELLLFT 592
Query: 232 EEANKMEIELTNRIRELVENNEKFKVSSET------KLSETVIDYECKLNEKQMELEASE 393
E +L + L +K S ++ +T I+ E +L K+ EL E
Sbjct: 593 ERLTSKNAQLQSESNSLQSQFDKVSCSESQLQSQCEQMKQTNINLESRLL-KEEELRKEE 651
Query: 394 LK-YQDXXXXXXXXXXXXXXXXDYAQEELKVVNKKNQRMLKDVKKQLEK-EVKLTQ-ETQ 564
++ Q + ++EL +K+ +KD+ KQL++ KL Q E+
Sbjct: 652 VQTLQAELACRQTEVKALSTQVEELKDELVTQRRKHASSIKDLTKQLQQARRKLDQVESG 711
Query: 565 SRLEEVVSSGSQNSQTKINEYLSGVSFKMANNDDQSSLYSSQNNGIDNCPMSPSISNSIA 744
S +EV S GS++S SG ++ +D+S + + +DN P
Sbjct: 712 SYDKEVSSMGSRSSS-------SGSLNARSSAEDRSPENTGSSVAVDNFPQV-------- 756
Query: 745 VTDDELKNLLDRFTSVQNDFGESKRLIESLNHDKSELIKTIEGQQSIILNYI 900
+ L++R +Q IE + +L++ I + II +YI
Sbjct: 757 ----DKAMLIERIVRLQKAHARKNEKIEFMEDHIKQLVEEIRKKTKIIQSYI 804
>sp|O33600|RAD50_SULAC DNA double-strand break repair rad50 ATPase
Length = 886
Score = 43.9 bits (102), Expect = 6e-04
Identities = 52/251 (20%), Positives = 104/251 (41%), Gaps = 33/251 (13%)
Frame = +1
Query: 184 INELKKTHEKEMETIKEEANKMEIELTNRIRELVEN-------NEKFKVSSETKLSETVI 342
I ++ K E E++ +K+E +++++L N RE E N +F E K+ ++
Sbjct: 187 IKDILKREEAEIDRLKKEIEEIKVKLENIEREAKEKEDELNQYNTEFNRIKEIKVQYDIL 246
Query: 343 DYECKLNEKQMELEASELKYQDXXXXXXXXXXXXXXXXDYAQEELKVVN----------- 489
E + K++E A LK + D +E++ ++
Sbjct: 247 SGELSVVNKKIEEIALRLKDFEEKEKRYNKIETEVKELDENREKINTISSFKSILVQIDS 306
Query: 490 ------------KKNQRMLKDVKKQLEKEVKLTQETQSRLEEVVSSGSQNSQTKINEYLS 633
K+ + LK KK+LE++ K +E + R +E+ + + + E
Sbjct: 307 LKSQINVVENDLKRKKEKLKR-KKELEEKEKQYEEIEKRKKEL-----EEKEKQYEEIEK 360
Query: 634 GVSFKMANNDDQSSLYSSQNNGIDNCPMSPSI---SNSIAVTDDELKNLLDRFTSVQNDF 804
+++ + N + Q + N +D + I S+ I D+ELK LLDR +
Sbjct: 361 RLTYVLKNIERQKNEIEKLNY-VDTQDLENKIKDVSDRINQIDNELKGLLDRRGDLNGRK 419
Query: 805 GESKRLIESLN 837
++ ++ +LN
Sbjct: 420 EQTLKIYNNLN 430
Score = 38.9 bits (89), Expect = 0.020
Identities = 56/304 (18%), Positives = 123/304 (40%), Gaps = 34/304 (11%)
Frame = +1
Query: 67 KEIEDQISNHNAQIETLKNEFDAXXXXXXXXXXXXXXXRINELKKTHEK--------EME 222
+EI+ Q+ N QI L+ ++ ++ K++ EK E++
Sbjct: 454 EEIKVQLLELNKQITALQARINSLIKEREELEATRNKLQLELQKRSKEKGIYEAKLKELQ 513
Query: 223 TIKEEANKMEIELTNRI-------------RELVENNEKFKVSSETKLSETVIDYECKLN 363
++EE NK++ E+ + + +EL++ +E++ +S+ L E + + E +LN
Sbjct: 514 RLEEEKNKLQNEILSLLSYHQEFENIAEKEKELIDYHEEYLKNSDI-LEEDIQEQEQRLN 572
Query: 364 EKQMELEASELKYQDXXXXXXXXXXXXXXXXDYAQ---------EELKVVNKKNQRMLKD 516
E +L E Y D + E+LK+ ++ + +
Sbjct: 573 ELNSKLSELEKSYNDYKAKYQFLPADLKSLVSLEERIRRRISELEKLKIEYERLKEEITR 632
Query: 517 VKKQLEKEVKLTQETQSRLEEVVSSG-SQNSQTKINEYLSGVSFKMANND-DQSSLYSSQ 690
+K E+ KL +E + L + G S+ ++ E + +S ++ + D+ + S
Sbjct: 633 MKGLKEEYEKLKEEEDALLNRISELGYSEKRYKQLEEIIDKLSKILSGIEADKGKIKGSL 692
Query: 691 NNGIDNCPMSPSISNSIAVTDDELKNLLDRFTSVQNDFGESKRLIESLN--HDKSELIKT 864
I N +EL+N ++ + + + ++L E L+ H +S ++
Sbjct: 693 EEKIKNIEEKER-------NIEELRNKMNEESKLNLGISKLQKLREVLDNKHLQSHIMNI 745
Query: 865 IEGQ 876
+ Q
Sbjct: 746 VRNQ 749
Database: Non-redundant SwissProt sequences
Posted date: Dec 6, 2005 7:40 AM
Number of letters in database: 68,354,980
Number of sequences in database: 184,735
Database: swissprot.01
Posted date: Dec 6, 2005 8:18 AM
Number of letters in database: 66,202,850
Number of sequences in database: 184,431
Lambda K H
0.305 0.123 0.313
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 74,844,301
Number of Sequences: 369166
Number of extensions: 1270893
Number of successful extensions: 4001
Number of sequences better than 10.0: 10
Number of HSP's better than 10.0 without gapping: 3540
Number of HSP's successfully gapped in prelim test: 0
Number of HSP's that attempted gapping in prelim test: 0
Number of HSP's gapped (non-prelim): 3918
length of database: 68,354,980
effective HSP length: 110
effective length of database: 48,034,130
effective search space used: 9078450570
frameshift window, decay const: 40, 0.1
T: 12
A: 40
X1: 16 ( 7.0 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 43 (21.9 bits)