Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= Dr_sW_007_C20-2
(646 letters)
Database: Non-redundant SwissProt sequences
184,735 sequences; 68,354,980 total letters
Score E
Sequences producing significant alignments: (bits) Value
sp|P49614|HEXB_FELCA Beta-hexosaminidase beta chain precurs... 270 2e-72
sp|P06865|HEXA_HUMAN Beta-hexosaminidase alpha chain precur... 268 9e-72
sp|P07686|HEXB_HUMAN Beta-hexosaminidase beta chain precurs... 266 3e-71
sp|P20060|HEXB_MOUSE Beta-hexosaminidase beta chain precurs... 266 4e-71
sp|P29416|HEXA_MOUSE Beta-hexosaminidase alpha chain precur... 258 9e-69
sp|Q29548|HEXB_PIG Beta-hexosaminidase beta chain precursor... 230 2e-60
sp|Q22492|HEXA_CAEEL Probable beta-hexosaminidase A precurs... 203 3e-52
sp|P13723|HEXA_DICDI Beta-hexosaminidase A precursor (N-ace... 157 2e-38
sp|Q8WSF3|FDL_DROME Probable beta-hexosaminidase fdl precur... 144 2e-34
sp|P49010|HEXC_BOMMO Chitooligosaccharidolytic beta-N-acety... 140 4e-33
>sp|P49614|HEXB_FELCA Beta-hexosaminidase beta chain precursor
(N-acetyl-beta-glucosaminidase)
(Beta-N-acetylhexosaminidase) (Hexosaminidase B)
Length = 499
Score = 270 bits (691), Expect = 2e-72
Identities = 122/212 (57%), Positives = 162/212 (76%)
Frame = +1
Query: 4 LYDQPRFSFRGLMLDTSRHFLSVQSILDNIELMSISKLNVFHWHIVDDESFPYQSKVFPD 183
+ D PRF RG+++DT+RHFL V+SIL ++ M+ +K NV HWHIVDD+SFPYQS FP+
Sbjct: 136 IIDSPRFPHRGILIDTARHFLPVKSILKTLDAMAFNKFNVLHWHIVDDQSFPYQSVTFPE 195
Query: 184 LSDKGSYHRYSHVYSQRDVIRILDFARRRGIRVVPEFDSPGHSLSWGKGQPNLLTPCYSG 363
LS+KGSY SHVY+ DV ++++AR RGIRV+PEFDSPGH+ SWGKGQ +LLTPCY+
Sbjct: 196 LSNKGSYS-LSHVYTPNDVHTVIEYARLRGIRVIPEFDSPGHTQSWGKGQKDLLTPCYNE 254
Query: 364 SKPNGYYGPIDPTLDSTYTFLSQLFKEVLDVFPDNYLHLGGDEVNFNCWQSNPKIVNFTI 543
K +G +GPI+P L+STY FLSQ FKEV VFPD+++HLGGDEV F CW+SNP+I F
Sbjct: 255 HKQSGTFGPINPILNSTYNFLSQFFKEVSMVFPDHFVHLGGDEVEFQCWESNPEIQGFMK 314
Query: 544 KHGFPNDFAKLQGYYMVKLISLVQNLFKNEIL 639
+ GF DF +L+ +Y+ KL+ +V + K I+
Sbjct: 315 QKGFGKDFRRLESFYLQKLLGIVSTVKKGSIV 346
>sp|P06865|HEXA_HUMAN Beta-hexosaminidase alpha chain precursor
(N-acetyl-beta-glucosaminidase)
(Beta-N-acetylhexosaminidase) (Hexosaminidase A)
Length = 529
Score = 268 bits (685), Expect = 9e-72
Identities = 118/210 (56%), Positives = 163/210 (77%)
Frame = +1
Query: 10 DQPRFSFRGLMLDTSRHFLSVQSILDNIELMSISKLNVFHWHIVDDESFPYQSKVFPDLS 189
D PRF RGL+LDTSRH+L + SILD +++M+ +KLNVFHWH+VDD SFPY+S FP+L
Sbjct: 163 DFPRFPHRGLLLDTSRHYLPLSSILDTLDVMAYNKLNVFHWHLVDDPSFPYESFTFPELM 222
Query: 190 DKGSYHRYSHVYSQRDVIRILDFARRRGIRVVPEFDSPGHSLSWGKGQPNLLTPCYSGSK 369
KGSY+ +H+Y+ +DV ++++AR RGIRV+ EFD+PGH+LSWG G P LLTPCYSGS+
Sbjct: 223 RKGSYNPVTHIYTAQDVKEVIEYARLRGIRVLAEFDTPGHTLSWGPGIPGLLTPCYSGSE 282
Query: 370 PNGYYGPIDPTLDSTYTFLSQLFKEVLDVFPDNYLHLGGDEVNFNCWQSNPKIVNFTIKH 549
P+G +GP++P+L++TY F+S F EV VFPD YLHLGGDEV+F CW+SNP+I +F K
Sbjct: 283 PSGTFGPVNPSLNNTYEFMSTFFLEVSSVFPDFYLHLGGDEVDFTCWKSNPEIQDFMRKK 342
Query: 550 GFPNDFAKLQGYYMVKLISLVQNLFKNEIL 639
GF DF +L+ +Y+ L+ +V + K ++
Sbjct: 343 GFGEDFKQLESFYIQTLLDIVSSYGKGYVV 372
>sp|P07686|HEXB_HUMAN Beta-hexosaminidase beta chain precursor
(N-acetyl-beta-glucosaminidase)
(Beta-N-acetylhexosaminidase) (Hexosaminidase B)
(Cervical cancer proto-oncogene 7) (HCC-7) [Contains:
Beta-hexosaminidase beta-B chain; Beta-hexosaminidase
beta-A chain]
Length = 556
Score = 266 bits (680), Expect = 3e-71
Identities = 118/212 (55%), Positives = 162/212 (76%)
Frame = +1
Query: 4 LYDQPRFSFRGLMLDTSRHFLSVQSILDNIELMSISKLNVFHWHIVDDESFPYQSKVFPD 183
+ D PRFS RG+++DTSRH+L V+ IL ++ M+ +K NV HWHIVDD+SFPYQS FP+
Sbjct: 194 IIDSPRFSHRGILIDTSRHYLPVKIILKTLDAMAFNKFNVLHWHIVDDQSFPYQSITFPE 253
Query: 184 LSDKGSYHRYSHVYSQRDVIRILDFARRRGIRVVPEFDSPGHSLSWGKGQPNLLTPCYSG 363
LS+KGSY SHVY+ DV ++++AR RGIRV+PEFD+PGH+LSWGKGQ +LLTPCYS
Sbjct: 254 LSNKGSYS-LSHVYTPNDVRMVIEYARLRGIRVLPEFDTPGHTLSWGKGQKDLLTPCYSR 312
Query: 364 SKPNGYYGPIDPTLDSTYTFLSQLFKEVLDVFPDNYLHLGGDEVNFNCWQSNPKIVNFTI 543
+GPI+PTL++TY+FL+ FKE+ +VFPD ++HLGGDEV F CW+SNPKI +F
Sbjct: 313 QNKLDSFGPINPTLNTTYSFLTTFFKEISEVFPDQFIHLGGDEVEFKCWESNPKIQDFMR 372
Query: 544 KHGFPNDFAKLQGYYMVKLISLVQNLFKNEIL 639
+ GF DF KL+ +Y+ K++ ++ + K I+
Sbjct: 373 QKGFGTDFKKLESFYIQKVLDIIATINKGSIV 404
>sp|P20060|HEXB_MOUSE Beta-hexosaminidase beta chain precursor
(N-acetyl-beta-glucosaminidase)
(Beta-N-acetylhexosaminidase) (Hexosaminidase B)
Length = 536
Score = 266 bits (679), Expect = 4e-71
Identities = 116/210 (55%), Positives = 157/210 (74%)
Frame = +1
Query: 10 DQPRFSFRGLMLDTSRHFLSVQSILDNIELMSISKLNVFHWHIVDDESFPYQSKVFPDLS 189
D PRF RG+++DTSRHFL V++IL ++ M+ +K NV HWHIVDD+SFPYQS FP+LS
Sbjct: 175 DSPRFPHRGILIDTSRHFLPVKTILKTLDAMAFNKFNVLHWHIVDDQSFPYQSTTFPELS 234
Query: 190 DKGSYHRYSHVYSQRDVIRILDFARRRGIRVVPEFDSPGHSLSWGKGQPNLLTPCYSGSK 369
+KGSY SHVY+ DV +L++AR RGIRV+PEFD+PGH+ SWGKGQ NLLTPCY+
Sbjct: 235 NKGSYS-LSHVYTPNDVRMVLEYARLRGIRVIPEFDTPGHTQSWGKGQKNLLTPCYNQKT 293
Query: 370 PNGYYGPIDPTLDSTYTFLSQLFKEVLDVFPDNYLHLGGDEVNFNCWQSNPKIVNFTIKH 549
+GP+DPT+++TY F + FKE+ VFPD ++HLGGDEV F CW SNP I F +
Sbjct: 294 KTQVFGPVDPTVNTTYAFFNTFFKEISSVFPDQFIHLGGDEVEFQCWASNPNIQGFMKRK 353
Query: 550 GFPNDFAKLQGYYMVKLISLVQNLFKNEIL 639
GF +DF +L+ +Y+ K++ ++ +L KN I+
Sbjct: 354 GFGSDFRRLESFYIKKILEIISSLKKNSIV 383
>sp|P29416|HEXA_MOUSE Beta-hexosaminidase alpha chain precursor
(N-acetyl-beta-glucosaminidase)
(Beta-N-acetylhexosaminidase) (Hexosaminidase A)
Length = 528
Score = 258 bits (659), Expect = 9e-69
Identities = 115/210 (54%), Positives = 160/210 (76%)
Frame = +1
Query: 10 DQPRFSFRGLMLDTSRHFLSVQSILDNIELMSISKLNVFHWHIVDDESFPYQSKVFPDLS 189
D PRF RG++LDTSRH+L + SILD +++M+ +K NVFHWH+VDD SFPY+S FP+L+
Sbjct: 163 DFPRFPHRGVLLDTSRHYLPLSSILDTLDVMAYNKFNVFHWHLVDDSSFPYESFTFPELT 222
Query: 190 DKGSYHRYSHVYSQRDVIRILDFARRRGIRVVPEFDSPGHSLSWGKGQPNLLTPCYSGSK 369
KGS++ +H+Y+ +DV ++++AR RGIRV+ EFD+PGH+LSWG G P LLTPCYSGS
Sbjct: 223 RKGSFNPVTHIYTAQDVKEVIEYARLRGIRVLAEFDTPGHTLSWGPGAPGLLTPCYSGSH 282
Query: 370 PNGYYGPIDPTLDSTYTFLSQLFKEVLDVFPDNYLHLGGDEVNFNCWQSNPKIVNFTIKH 549
+G +GP++P+L+STY F+S LF E+ VFPD YLHLGGDEV+F CW+SNP I F K
Sbjct: 283 LSGTFGPVNPSLNSTYDFMSTLFLEISSVFPDFYLHLGGDEVDFTCWKSNPNIQAFMKKK 342
Query: 550 GFPNDFAKLQGYYMVKLISLVQNLFKNEIL 639
GF DF +L+ +Y+ L+ +V + K ++
Sbjct: 343 GF-TDFKQLESFYIQTLLDIVSDYDKGYVV 371
>sp|Q29548|HEXB_PIG Beta-hexosaminidase beta chain precursor
(N-acetyl-beta-glucosaminidase)
(Beta-N-acetylhexosaminidase) (Hexosaminidase B) (65 kDa
epididymal boar protein)
Length = 531
Score = 230 bits (587), Expect = 2e-60
Identities = 105/184 (57%), Positives = 139/184 (75%)
Frame = +1
Query: 4 LYDQPRFSFRGLMLDTSRHFLSVQSILDNIELMSISKLNVFHWHIVDDESFPYQSKVFPD 183
+ D PRF RG+++DT RHFLSV++I ++ M+ +K NV HWHIVDD+SFPYQS F
Sbjct: 168 IIDFPRFPHRGILIDTGRHFLSVKTIFKTLDAMAFNKFNVLHWHIVDDQSFPYQSINFGV 227
Query: 184 LSDKGSYHRYSHVYSQRDVIRILDFARRRGIRVVPEFDSPGHSLSWGKGQPNLLTPCYSG 363
LS KGSY SHVY+ DV ++++AR RGIRV+PEFD+PGHS SWGKGQ +LLTPCY
Sbjct: 228 LSSKGSYS-LSHVYTPNDVRMVIEYARIRGIRVMPEFDTPGHSRSWGKGQKDLLTPCYRK 286
Query: 364 SKPNGYYGPIDPTLDSTYTFLSQLFKEVLDVFPDNYLHLGGDEVNFNCWQSNPKIVNFTI 543
+G +GPI+P L++TY FLS+ FKE+ VFPD ++H+GGDEV+F+CW SN +I+ F
Sbjct: 287 QVLSGTFGPINPILNTTYNFLSKFFKEISTVFPDEFIHIGGDEVDFDCWASNSEILQFMQ 346
Query: 544 KHGF 555
+ GF
Sbjct: 347 EKGF 350
>sp|Q22492|HEXA_CAEEL Probable beta-hexosaminidase A precursor
(N-acetyl-beta-glucosaminidase)
(Beta-N-acetylhexosaminidase)
Length = 555
Score = 203 bits (517), Expect = 3e-52
Identities = 99/210 (47%), Positives = 138/210 (65%), Gaps = 4/210 (1%)
Frame = +1
Query: 4 LYDQPRFSFRGLMLDTSRHFLSVQSILDNIELMSISKLNVFHWHIVDDESFPYQSKVFPD 183
++D+PRF RG+M+D+SRHFLSV I +E+MS++KLNV HWH+VD ESFPY S FP+
Sbjct: 164 IFDKPRFPVRGIMIDSSRHFLSVNVIKRQLEIMSMNKLNVLHWHLVDSESFPYTSVKFPE 223
Query: 184 LSDKGSYHRYSHVYSQRDVIRILDFARRRGIRVVPEFDSPGHSLSWGKGQPNLLTPCYSG 363
L G+Y HVYS+ D+ ++ FAR RGIRV+PEFD PGH+ SW +G+ LT C+
Sbjct: 224 LHGVGAYSP-RHVYSREDIADVIAFARLRGIRVIPEFDLPGHTSSW-RGRKGFLTECFDE 281
Query: 364 SKPNGYY-GPIDPTLDSTYTFLSQLFKEVLDVFPDNYLHLGGDEVN---FNCWQSNPKIV 531
+ +DP ++ + F+S+ +EV + FPD +LHLGGDEV+ CW+ N KI
Sbjct: 282 KGVETFLPNLVDPMNEANFDFISEFLEEVTETFPDQFLHLGGDEVSDYIVECWERNKKIR 341
Query: 532 NFTIKHGFPNDFAKLQGYYMVKLISLVQNL 621
F + GF ND L+ Y+ KL +V+NL
Sbjct: 342 KFMEEKGFGNDTVLLENYFFEKLYKIVENL 371
>sp|P13723|HEXA_DICDI Beta-hexosaminidase A precursor (N-acetyl-beta-glucosaminidase)
(Beta-N-acetylhexosaminidase)
Length = 532
Score = 157 bits (397), Expect = 2e-38
Identities = 76/184 (41%), Positives = 114/184 (61%), Gaps = 2/184 (1%)
Frame = +1
Query: 10 DQPRFSFRGLMLDTSRHFLSVQSILDNIELMSISKLNVFHWHIVDDESFPYQSKVFPDLS 189
D PR+ +RG M+D++RH++ IL I+ + SK N HWH+VD +FP +S +PDL+
Sbjct: 151 DSPRYPWRGFMVDSARHYIPKNMILHMIDSLGFSKFNTLHWHMVDAVAFPVESTTYPDLT 210
Query: 190 DKGSYHRYSHVYSQRDVIRILDFARRRGIRVVPEFDSPGHSLSWGKGQPNLLTPC--YSG 363
KG++ S +S D+ ++ +A+ GIRV+PEFD PGH+ +WG G P L+ C Y+
Sbjct: 211 -KGAFSP-SATFSHDDIQEVVAYAKTYGIRVIPEFDIPGHAAAWGIGYPELVATCPDYAA 268
Query: 364 SKPNGYYGPIDPTLDSTYTFLSQLFKEVLDVFPDNYLHLGGDEVNFNCWQSNPKIVNFTI 543
+ N P+D + +T+TF+ LF E+ +F DNY H GGDE+ CW +P I N+
Sbjct: 269 NVNN---IPLDISNPATFTFIQNLFTEIAPLFIDNYFHTGGDELVTGCWLEDPAIANWMT 325
Query: 544 KHGF 555
K GF
Sbjct: 326 KMGF 329
>sp|Q8WSF3|FDL_DROME Probable beta-hexosaminidase fdl precursor (Fused lobes protein)
Length = 660
Score = 144 bits (363), Expect = 2e-34
Identities = 75/178 (42%), Positives = 112/178 (62%), Gaps = 11/178 (6%)
Frame = +1
Query: 10 DQPRFSFRGLMLDTSRHFLSVQSILDNIELMSISKLNVFHWHIVDDESFPYQSKVFPDLS 189
D P+F +RGLMLDTSRHF SV+SI I M ++K+N FHWH+ D +SFPY S+ +P+L+
Sbjct: 272 DAPKFRYRGLMLDTSRHFFSVESIKRTIVGMGLAKMNRFHWHLTDAQSFPYISRYYPELA 331
Query: 190 DKGSYHRYSHVYSQRDVIRILDFARRRGIRVVPEFDSPGHS---LSWG-KGQPNLLTPCY 357
G+Y S YS++DV + +FA+ G++V+PE D+P H+ WG K L C
Sbjct: 332 VHGAYSE-SETYSEQDVREVAEFAKIYGVQVIPEIDAPAHAGNGWDWGPKRGMGELAMCI 390
Query: 358 SGSKPNGYY------GPIDPTLDSTYTFLSQLFKEVLD-VFPDNYLHLGGDEVNFNCW 510
+ +P +Y G ++P + TY L ++++E+L P ++ HLGGDEVN +CW
Sbjct: 391 N-QQPWSFYCGEPPCGQLNPKNNYTYLILQRIYEELLQHTGPTDFFHLGGDEVNLDCW 447
>sp|P49010|HEXC_BOMMO Chitooligosaccharidolytic beta-N-acetylglucosaminidase precursor
(Beta-GlcNAcase) (Beta-hexosaminidase)
(Beta-N-acetylhexosaminidase)
Length = 596
Score = 140 bits (352), Expect = 4e-33
Identities = 75/203 (36%), Positives = 121/203 (59%), Gaps = 10/203 (4%)
Frame = +1
Query: 10 DQPRFSFRGLMLDTSRHFLSVQSILDNIELMSISKLNVFHWHIVDDESFPYQSKVFPDLS 189
D+P + +RG++LDT+R+F S+ SI I+ M+ KLN FHWHI D +SFP + P+LS
Sbjct: 207 DRPVYPYRGILLDTARNFYSIDSIKRTIDAMAAVKLNTFHWHITDSQSFPLVLQKRPNLS 266
Query: 190 DKGSYHRYSHVYSQRDVIRILDFARRRGIRVVPEFDSPGHSLSWGKG-QPNLLTPCYSGS 366
G+Y + VY+++D+ ++++ RG+RV+PEFD+P H G+G Q LT C+
Sbjct: 267 KLGAYSP-TKVYTKQDIREVVEYGLERGVRVLPEFDAPAHV---GEGWQDTGLTVCFKAE 322
Query: 367 KPNGY-----YGPIDPTLDSTYTFLSQLFKEVLDVFPD-NYLHLGGDEVNFNCWQSNPKI 528
+ G ++PT + Y +L ++ E+ + F + H+GGDEV+ CW S+ +I
Sbjct: 323 PWTKFCVEPPCGQLNPTKEELYDYLEDIYVEMAEAFESTDMFHMGGDEVSERCWNSSEEI 382
Query: 529 VNFTIKHGFPND---FAKLQGYY 588
NF I++ + D F KL Y+
Sbjct: 383 QNFMIQNRWNLDKSSFLKLWNYF 405
Database: Non-redundant SwissProt sequences
Posted date: Dec 6, 2005 7:40 AM
Number of letters in database: 68,354,980
Number of sequences in database: 184,735
Database: swissprot.01
Posted date: Dec 6, 2005 8:18 AM
Number of letters in database: 66,202,850
Number of sequences in database: 184,431
Lambda K H
0.318 0.134 0.401
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 79,880,573
Number of Sequences: 369166
Number of extensions: 1754922
Number of successful extensions: 4682
Number of sequences better than 10.0: 10
Number of HSP's better than 10.0 without gapping: 4517
Number of HSP's successfully gapped in prelim test: 0
Number of HSP's that attempted gapping in prelim test: 0
Number of HSP's gapped (non-prelim): 4654
length of database: 68,354,980
effective HSP length: 106
effective length of database: 48,773,070
effective search space used: 5267491560
frameshift window, decay const: 40, 0.1
T: 12
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)