Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= Dr_sW_007_C05
(758 letters)
Database: Non-redundant SwissProt sequences
184,735 sequences; 68,354,980 total letters
Score E
Sequences producing significant alignments: (bits) Value
sp|P07711|CATL_HUMAN Cathepsin L precursor (Major excreted ... 262 8e-70
sp|O60911|CATL2_HUMAN Cathepsin L2 precursor (Cathepsin V) ... 258 9e-69
sp|Q9GL24|CATL_CANFA Cathepsin L precursor [Contains: Cathe... 256 6e-68
sp|P25975|CATL_BOVIN Cathepsin L precursor [Contains: Cathe... 255 1e-67
sp|Q28944|CATL_PIG Cathepsin L precursor [Contains: Catheps... 247 3e-65
sp|Q24940|CATLP_FASHE Cathepsin L-like proteinase precursor 246 5e-65
sp|P06797|CATL_MOUSE Cathepsin L precursor (Major excreted ... 243 3e-64
sp|P07154|CATL_RAT Cathepsin L precursor (Major excreted pr... 240 3e-63
sp|P43236|CATK_RABIT Cathepsin K precursor (OC-2 protein) 238 1e-62
sp|Q26636|CATL_SARPE Cathepsin L precursor [Contains: Cathe... 237 2e-62
>sp|P07711|CATL_HUMAN Cathepsin L precursor (Major excreted protein) (MEP) [Contains:
Cathepsin L heavy chain; Cathepsin L light chain]
Length = 333
Score = 262 bits (669), Expect = 8e-70
Identities = 132/227 (58%), Positives = 157/227 (69%), Gaps = 1/227 (0%)
Frame = +2
Query: 20 RRLIWEQNLKYIQKHNLEYDLGKHTYSLGLNQFADMTNEEFKAKYLGIMKTKPTLEGSTY 199
RR +WE+N+K I+ HN EY GKH++++ +N F DMT+EEF+ G KP +G +
Sbjct: 48 RRAVWEKNMKMIELHNQEYREGKHSFTMAMNAFGDMTSEEFRQVMNGFQNRKPR-KGKVF 106
Query: 200 MAPENIGVLPASVDWRQKGYVTPVKNQQQCGSCWSFSATGSLEGQYFRKNNRLISFSEQQ 379
P P SVDWR+KGYVTPVKNQ QCGSCW+FSATG+LEGQ FRK RLIS SEQ
Sbjct: 107 QEPLFYEA-PRSVDWREKGYVTPVKNQGQCGSCWAFSATGALEGQMFRKTGRLISLSEQN 165
Query: 380 LVDCSGAYGNYGCGAGLMDNAFRYIKDQ-GIESEGDYPYTATDGTCKRNPSKIVTKCTGF 556
LVDCSG GN GC GLMD AF+Y++D G++SE YPY AT+ +CK NP V TGF
Sbjct: 166 LVDCSGPQGNEGCNGGLMDYAFQYVQDNGGLDSEESYPYEATEESCKYNPKYSVANDTGF 225
Query: 557 TDIQSQNETDLANAVATVGPVSVAIDAGHASFQLYKSGIYNEESCST 697
DI Q E L AVATVGP+SVAIDAGH SF YK GIY E CS+
Sbjct: 226 VDIPKQ-EKALMKAVATVGPISVAIDAGHESFLFYKEGIYFEPDCSS 271
>sp|O60911|CATL2_HUMAN Cathepsin L2 precursor (Cathepsin V) (Cathepsin U)
Length = 334
Score = 258 bits (660), Expect = 9e-69
Identities = 125/230 (54%), Positives = 158/230 (68%), Gaps = 1/230 (0%)
Frame = +2
Query: 20 RRLIWEQNLKYIQKHNLEYDLGKHTYSLGLNQFADMTNEEFKAKYLGIMKTKPTLEGSTY 199
RR +WE+N+K I+ HN EY GKH +++ +N F DMTNEEF+ + +G + + +G +
Sbjct: 48 RRAVWEKNMKMIELHNGEYSQGKHGFTMAMNAFGDMTNEEFR-QMMGCFRNQKFRKGKVF 106
Query: 200 MAPENIGVLPASVDWRQKGYVTPVKNQQQCGSCWSFSATGSLEGQYFRKNNRLISFSEQQ 379
P + LP SVDWR+KGYVTPVKNQ+QCGSCW+FSATG+LEGQ FRK +L+S SEQ
Sbjct: 107 REPLFLD-LPKSVDWRKKGYVTPVKNQKQCGSCWAFSATGALEGQMFRKTGKLVSLSEQN 165
Query: 380 LVDCSGAYGNYGCGAGLMDNAFRYIKDQ-GIESEGDYPYTATDGTCKRNPSKIVTKCTGF 556
LVDCS GN GC G M AF+Y+K+ G++SE YPY A D CK P V TGF
Sbjct: 166 LVDCSRPQGNQGCNGGFMARAFQYVKENGGLDSEESYPYVAVDEICKYRPENSVANDTGF 225
Query: 557 TDIQSQNETDLANAVATVGPVSVAIDAGHASFQLYKSGIYNEESCSTTQI 706
T + E L AVATVGP+SVA+DAGH+SFQ YKSGIY E CS+ +
Sbjct: 226 TVVAPGKEKALMKAVATVGPISVAMDAGHSSFQFYKSGIYFEPDCSSKNL 275
>sp|Q9GL24|CATL_CANFA Cathepsin L precursor [Contains: Cathepsin L heavy chain; Cathepsin
L light chain]
Length = 333
Score = 256 bits (653), Expect = 6e-68
Identities = 129/231 (55%), Positives = 155/231 (67%), Gaps = 2/231 (0%)
Frame = +2
Query: 20 RRLIWEQNLKYIQKHNLEYDLGKHTYSLGLNQFADMTNEEFKAKYLGIMKTKPTLEGSTY 199
RR +WE+N+K I+ HN EY GKH +++ +N F DMTNEEF+ G K +G +
Sbjct: 48 RRAVWEKNMKMIELHNREYSQGKHGFTMAMNAFGDMTNEEFRQVMNGFQNQKHK-KGKMF 106
Query: 200 MAPENIGVLPASVDWRQKGYVTPVKNQQQCGSCWSFSATGSLEGQYFRKNNRLISFSEQQ 379
P +P SVDWR+KGYVTPVKNQ QCGSCW+FSATG+LEGQ FRK +L+S SEQ
Sbjct: 107 QEPL-FAEIPKSVDWREKGYVTPVKNQGQCGSCWAFSATGALEGQMFRKTGKLVSLSEQN 165
Query: 380 LVDCSGAYGNYGCGAGLMDNAFRYIKDQ-GIESEGDYPYTATD-GTCKRNPSKIVTKCTG 553
LVDCS A GN GC GLMDNAFRY+KD G++SE YPY D TC P TG
Sbjct: 166 LVDCSRAQGNEGCNGGLMDNAFRYVKDNGGLDSEESYPYLGRDTETCNYKPECSAANDTG 225
Query: 554 FTDIQSQNETDLANAVATVGPVSVAIDAGHASFQLYKSGIYNEESCSTTQI 706
F D+ Q E L AVAT+GP+SVAIDAGH SFQ YKSGIY + CS+ +
Sbjct: 226 FVDL-PQREKALMKAVATLGPISVAIDAGHQSFQFYKSGIYFDPDCSSKDL 275
>sp|P25975|CATL_BOVIN Cathepsin L precursor [Contains: Cathepsin L heavy chain; Cathepsin
L light chain]
Length = 334
Score = 255 bits (651), Expect = 1e-67
Identities = 132/227 (58%), Positives = 152/227 (66%), Gaps = 2/227 (0%)
Frame = +2
Query: 20 RRLIWEQNLKYIQKHNLEYDLGKHTYSLGLNQFADMTNEEFKAKYLGIMKTKPTLEGSTY 199
RR +WE+N K I HN EY GKH + + +N F DMTNEEF+ G K +G +
Sbjct: 48 RRAVWEKNKKIIDLHNQEYSEGKHAFRMAMNAFGDMTNEEFRQVMNGFQNQKHK-KGKLF 106
Query: 200 MAPENIGVLPASVDWRQKGYVTPVKNQQQCGSCWSFSATGSLEGQYFRKNNRLISFSEQQ 379
P + V P SVDW +KGYVTPVKNQ QCGSCW+FSATG+LEGQ FRK +L+S SEQ
Sbjct: 107 HEPLLVDV-PKSVDWTKKGYVTPVKNQGQCGSCWAFSATGALEGQMFRKTGKLVSLSEQN 165
Query: 380 LVDCSGAYGNYGCGAGLMDNAFRYIKDQ-GIESEGDYPYTATD-GTCKRNPSKIVTKCTG 553
LVDCS A GN GC GLMDNAF+YIKD G++SE YPY ATD +C P TG
Sbjct: 166 LVDCSRAQGNQGCNGGLMDNAFQYIKDNGGLDSEESYPYLATDTNSCNYKPECSAANDTG 225
Query: 554 FTDIQSQNETDLANAVATVGPVSVAIDAGHASFQLYKSGIYNEESCS 694
F DI Q E L AVATVGP+SVAIDAGH SFQ YKSGIY + CS
Sbjct: 226 FVDI-PQREKALMKAVATVGPISVAIDAGHTSFQFYKSGIYYDPDCS 271
>sp|Q28944|CATL_PIG Cathepsin L precursor [Contains: Cathepsin L heavy chain; Cathepsin
L light chain]
Length = 334
Score = 247 bits (630), Expect = 3e-65
Identities = 126/231 (54%), Positives = 154/231 (66%), Gaps = 2/231 (0%)
Frame = +2
Query: 20 RRLIWEQNLKYIQKHNLEYDLGKHTYSLGLNQFADMTNEEFKAKYLGIMKTKPTLEGSTY 199
RR +WE+N+K I+ HN EY GKH +S+ +N F DMTNEEF+ G K +G +
Sbjct: 48 RRAVWEKNMKMIELHNQEYSQGKHGFSMAMNAFGDMTNEEFRQVMNGFQNQKHK-KGKVF 106
Query: 200 MAPENIGVLPASVDWRQKGYVTPVKNQQQCGSCWSFSATGSLEGQYFRKNNRLISFSEQQ 379
+ V P SVDWR+KGYVT VKNQ QCGSCW+FSATG+LEGQ FRK +L+S SEQ
Sbjct: 107 HESLVLEV-PKSVDWREKGYVTAVKNQGQCGSCWAFSATGALEGQMFRKTGKLVSLSEQN 165
Query: 380 LVDCSGAYGNYGCGAGLMDNAFRYIKDQ-GIESEGDYPYTATD-GTCKRNPSKIVTKCTG 553
LVDCS GN GC GLMDNAF+Y+KD G+++E YPY + +C P TG
Sbjct: 166 LVDCSRPQGNQGCNGGLMDNAFQYVKDNGGLDTEESYPYLGRETNSCTYKPECSAANDTG 225
Query: 554 FTDIQSQNETDLANAVATVGPVSVAIDAGHASFQLYKSGIYNEESCSTTQI 706
F DI Q E L AVATVGP+SVAIDAGH+SFQ YKSGIY + CS+ +
Sbjct: 226 FVDI-PQREKALMKAVATVGPISVAIDAGHSSFQFYKSGIYYDPDCSSKDL 275
>sp|Q24940|CATLP_FASHE Cathepsin L-like proteinase precursor
Length = 326
Score = 246 bits (628), Expect = 5e-65
Identities = 117/232 (50%), Positives = 154/232 (66%)
Frame = +2
Query: 11 DITRRLIWEQNLKYIQKHNLEYDLGKHTYSLGLNQFADMTNEEFKAKYLGIMKTKPTLEG 190
D RR IWE+N+K+IQ+HNL +DLG TY+LGLNQF DMT EEFKAKYL M +
Sbjct: 37 DQHRRNIWEKNVKHIQEHNLRHDLGLVTYTLGLNQFTDMTFEEFKAKYLTEMSRASDILS 96
Query: 191 STYMAPENIGVLPASVDWRQKGYVTPVKNQQQCGSCWSFSATGSLEGQYFRKNNRLISFS 370
N +P +DWR+ GYVT VK+Q CGSCW+FS TG++EGQY + ISFS
Sbjct: 97 HGVPYEANNRAVPDKIDWRESGYVTEVKDQGNCGSCWAFSTTGTMEGQYMKNERTSISFS 156
Query: 371 EQQLVDCSGAYGNYGCGAGLMDNAFRYIKDQGIESEGDYPYTATDGTCKRNPSKIVTKCT 550
EQQLVDCSG +GN GC GLM+NA++Y+K G+E+E YPYTA +G C+ N V K T
Sbjct: 157 EQQLVDCSGPWGNNGCSGGLMENAYQYLKQFGLETESSYPYTAVEGQCRYNKQLGVAKVT 216
Query: 551 GFTDIQSQNETDLANAVATVGPVSVAIDAGHASFQLYKSGIYNEESCSTTQI 706
G+ + S +E +L N V P +VA+D + F +Y+SGIY ++CS ++
Sbjct: 217 GYYTVHSGSEVELKNLVGARRPAAVAVDV-ESDFMMYRSGIYQSQTCSPLRV 267
>sp|P06797|CATL_MOUSE Cathepsin L precursor (Major excreted protein) (MEP) (p39 cysteine
proteinase) [Contains: Cathepsin L heavy chain;
Cathepsin L light chain]
Length = 334
Score = 243 bits (621), Expect = 3e-64
Identities = 127/230 (55%), Positives = 153/230 (66%), Gaps = 1/230 (0%)
Frame = +2
Query: 20 RRLIWEQNLKYIQKHNLEYDLGKHTYSLGLNQFADMTNEEFKAKYLGIMKTKPTLEGSTY 199
RR IWE+N++ IQ HN EY G+H +S+ +N F DMTNEEF+ G K +G +
Sbjct: 48 RRAIWEKNMRMIQLHNGEYSNGQHGFSMEMNAFGDMTNEEFRQVVNGYRHQKHK-KGRLF 106
Query: 200 MAPENIGVLPASVDWRQKGYVTPVKNQQQCGSCWSFSATGSLEGQYFRKNNRLISFSEQQ 379
P + + P SVDWR+KG VTPVKNQ QCGSCW+FSA+G LEGQ F K +LIS SEQ
Sbjct: 107 QEPLMLKI-PKSVDWREKGCVTPVKNQGQCGSCWAFSASGCLEGQMFLKTGKLISLSEQN 165
Query: 380 LVDCSGAYGNYGCGAGLMDNAFRYIKDQ-GIESEGDYPYTATDGTCKRNPSKIVTKCTGF 556
LVDCS A GN GC GLMD AF+YIK+ G++SE YPY A DG+CK V TGF
Sbjct: 166 LVDCSHAQGNQGCNGGLMDFAFQYIKENGGLDSEESYPYEAKDGSCKYRAEFAVANDTGF 225
Query: 557 TDIQSQNETDLANAVATVGPVSVAIDAGHASFQLYKSGIYNEESCSTTQI 706
DI Q E L AVATVGP+SVA+DA H S Q Y SGIY E +CS+ +
Sbjct: 226 VDI-PQQEKALMKAVATVGPISVAMDASHPSLQFYSSGIYYEPNCSSKNL 274
>sp|P07154|CATL_RAT Cathepsin L precursor (Major excreted protein) (MEP) (Cyclic
protein 2) (CP-2) [Contains: Cathepsin L heavy chain;
Cathepsin L light chain]
Length = 334
Score = 240 bits (612), Expect = 3e-63
Identities = 124/230 (53%), Positives = 152/230 (66%), Gaps = 1/230 (0%)
Frame = +2
Query: 20 RRLIWEQNLKYIQKHNLEYDLGKHTYSLGLNQFADMTNEEFKAKYLGIMKTKPTLEGSTY 199
RR +WE+N++ IQ HN EY GKH +++ +N F DMTNEEF+ G K +G +
Sbjct: 48 RRAVWEKNMRMIQLHNGEYSNGKHGFTMEMNAFGDMTNEEFRQIVNGYRHQKHK-KGRLF 106
Query: 200 MAPENIGVLPASVDWRQKGYVTPVKNQQQCGSCWSFSATGSLEGQYFRKNNRLISFSEQQ 379
P + + P +VDWR+KG VTPVKNQ QCGSCW+FSA+G LEGQ F K +LIS SEQ
Sbjct: 107 QEPLMLQI-PKTVDWREKGCVTPVKNQGQCGSCWAFSASGCLEGQMFLKTGKLISLSEQN 165
Query: 380 LVDCSGAYGNYGCGAGLMDNAFRYIKDQ-GIESEGDYPYTATDGTCKRNPSKIVTKCTGF 556
LVDCS GN GC GLMD AF+YIK+ G++SE YPY A DG+CK V TGF
Sbjct: 166 LVDCSHDQGNQGCNGGLMDFAFQYIKENGGLDSEESYPYEAKDGSCKYRAEYAVANDTGF 225
Query: 557 TDIQSQNETDLANAVATVGPVSVAIDAGHASFQLYKSGIYNEESCSTTQI 706
DI Q E L AVATVGP+SVA+DA H S Q Y SGIY E +CS+ +
Sbjct: 226 VDI-PQQEKALMKAVATVGPISVAMDASHPSLQFYSSGIYYEPNCSSKDL 274
>sp|P43236|CATK_RABIT Cathepsin K precursor (OC-2 protein)
Length = 329
Score = 238 bits (607), Expect = 1e-62
Identities = 121/238 (50%), Positives = 157/238 (65%), Gaps = 3/238 (1%)
Frame = +2
Query: 2 ELTDITRRLIWEQNLKYIQKHNLEYDLGKHTYSLGLNQFADMTNEEFKAKYLGIMKTKPT 181
++ +I+RRLIWE+NLK+I HNLE LG HTY L +N DMT+EE K G+ K P+
Sbjct: 40 KVDEISRRLIWEKNLKHISIHNLEASLGVHTYELAMNHLGDMTSEEVVQKMTGL-KVPPS 98
Query: 182 LEGS--TYMAPENIGVLPASVDWRQKGYVTPVKNQQQCGSCWSFSATGSLEGQYFRKNNR 355
S T P+ G P S+D+R+KGYVTPVKNQ QCGSCW+FS+ G+LEGQ +K +
Sbjct: 99 RSHSNDTLYIPDWEGRTPDSIDYRKKGYVTPVKNQGQCGSCWAFSSVGALEGQLKKKTGK 158
Query: 356 LISFSEQQLVDCSGAYGNYGCGAGLMDNAFRYI-KDQGIESEGDYPYTATDGTCKRNPSK 532
L++ S Q LVDC NYGCG G M NAF+Y+ +++GI+SE YPY D +C NP+
Sbjct: 159 LLNLSPQNLVDCVSE--NYGCGGGYMTNAFQYVQRNRGIDSEDAYPYVGQDESCMYNPTG 216
Query: 533 IVTKCTGFTDIQSQNETDLANAVATVGPVSVAIDAGHASFQLYKSGIYNEESCSTTQI 706
KC G+ +I NE L AVA VGPVSVAIDA SFQ Y G+Y +E+CS+ +
Sbjct: 217 KAAKCRGYREIPEGNEKALKRAVARVGPVSVAIDASLTSFQFYSKGVYYDENCSSDNV 274
>sp|Q26636|CATL_SARPE Cathepsin L precursor [Contains: Cathepsin L heavy chain; Cathepsin
L light chain]
Length = 339
Score = 237 bits (605), Expect = 2e-62
Identities = 124/238 (52%), Positives = 155/238 (65%), Gaps = 8/238 (3%)
Frame = +2
Query: 2 ELTDITRRLIWEQNLKYIQKHNLEYDLGKHTYSLGLNQFADMTNEEFKAKYLG------- 160
E+ + R I+ +N I KHN + GK +Y LGLN++ADM + EFK G
Sbjct: 42 EVEERFRMKIFNENRHKIAKHNQLFAQGKVSYKLGLNKYADMLHHEFKETMNGYNHTLRQ 101
Query: 161 IMKTKPTLEGSTYMAPENIGVLPASVDWRQKGYVTPVKNQQQCGSCWSFSATGSLEGQYF 340
+M+ + L G+TY+ P ++ V P SVDWR+ G VT VK+Q CGSCW+FS+TG+LEGQ+F
Sbjct: 102 LMRERTGLVGATYIPPAHVTV-PKSVDWREHGAVTGVKDQGHCGSCWAFSSTGALEGQHF 160
Query: 341 RKNNRLISFSEQQLVDCSGAYGNYGCGAGLMDNAFRYIKDQ-GIESEGDYPYTATDGTCK 517
RK L+S SEQ LVDCS YGN GC GLMDNAFRYIKD GI++E YPY D +C
Sbjct: 161 RKAGVLVSLSEQNLVDCSTKYGNNGCNGGLMDNAFRYIKDNGGIDTEKSYPYEGIDDSCH 220
Query: 518 RNPSKIVTKCTGFTDIQSQNETDLANAVATVGPVSVAIDAGHASFQLYKSGIYNEESC 691
N + I TGF DI +E + AVAT+GPVSVAIDA H SFQLY G+YNE C
Sbjct: 221 FNKATIGATDTGFVDIPEGDEEKMKKAVATMGPVSVAIDASHESFQLYSEGVYNEPEC 278
Database: Non-redundant SwissProt sequences
Posted date: Dec 6, 2005 7:40 AM
Number of letters in database: 68,354,980
Number of sequences in database: 184,735
Database: swissprot.01
Posted date: Dec 6, 2005 8:18 AM
Number of letters in database: 66,202,850
Number of sequences in database: 184,431
Lambda K H
0.318 0.134 0.401
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 85,613,907
Number of Sequences: 369166
Number of extensions: 1698615
Number of successful extensions: 5297
Number of sequences better than 10.0: 10
Number of HSP's better than 10.0 without gapping: 4616
Number of HSP's successfully gapped in prelim test: 0
Number of HSP's that attempted gapping in prelim test: 0
Number of HSP's gapped (non-prelim): 4880
length of database: 68,354,980
effective HSP length: 108
effective length of database: 48,403,600
effective search space used: 6970118400
frameshift window, decay const: 40, 0.1
T: 12
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)