Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= Dr_sW_007_C04
(487 letters)
Database: Non-redundant SwissProt sequences
184,735 sequences; 68,354,980 total letters
Score E
Sequences producing significant alignments: (bits) Value
sp|O18404|HCD2_DROME 3-hydroxyacyl-CoA dehydrogenase type I... 193 2e-49
sp|O70351|HCD2_RAT 3-hydroxyacyl-CoA dehydrogenase type II ... 193 2e-49
sp|O02691|HCD2_BOVIN 3-hydroxyacyl-CoA dehydrogenase type I... 192 5e-49
sp|Q99714|HCD2_HUMAN 3-hydroxyacyl-CoA dehydrogenase type I... 189 3e-48
sp|O08756|HCD2_MOUSE 3-hydroxyacyl-CoA dehydrogenase type I... 188 6e-48
sp|Q9X248|FABG_THEMA 3-oxoacyl-[acyl-carrier-protein] reduc... 79 4e-15
sp|Q92506|DHB8_HUMAN Estradiol 17-beta-dehydrogenase 8 (17-... 70 3e-12
sp|P28643|FABG_CUPLA 3-oxoacyl-[acyl-carrier-protein] reduc... 67 2e-11
sp|P50171|DHB8_MOUSE Estradiol 17-beta-dehydrogenase 8 (17-... 67 3e-11
sp|P66781|YD50_MYCTU Putative oxidoreductase Rv1350/MT1393 ... 66 4e-11
>sp|O18404|HCD2_DROME 3-hydroxyacyl-CoA dehydrogenase type II (Type II HADH) (Scully
protein)
Length = 255
Score = 193 bits (491), Expect = 2e-49
Identities = 88/142 (61%), Positives = 114/142 (80%)
Frame = +1
Query: 1 VNAAGTFNMIRLCCSMFNSNEPNEFNQRGIVINTSSIAAFEGQCGQSAYSASQGAIVAMT 180
+N GTFN+IRL + +NEPN+ QRG+++NT+S+AAF+GQ GQ+AYSAS+ A+V MT
Sbjct: 114 INTVGTFNVIRLSAGLMGANEPNQDGQRGVIVNTASVAAFDGQIGQAAYSASKAAVVGMT 173
Query: 181 LPLARDLVAMGVRVMTIAPGIFLTPLLENVPDSARLNLSKIVPFPSRLGHPDEFAHLVQS 360
LP+ARDL G+R+ TIAPG+F TP+L +P+ R L+K +PFP RLG P E+AHLVQ+
Sbjct: 174 LPIARDLSTQGIRICTIAPGLFNTPMLAALPEKVRTFLAKSIPFPQRLGEPSEYAHLVQA 233
Query: 361 IIENPMLNGEVIRIDGALRMMP 426
I ENP+LNGEVIRIDGALRMMP
Sbjct: 234 IYENPLLNGEVIRIDGALRMMP 255
>sp|O70351|HCD2_RAT 3-hydroxyacyl-CoA dehydrogenase type II (Type II HADH) (Endoplasmic
reticulum-associated amyloid beta-peptide binding
protein)
Length = 261
Score = 193 bits (490), Expect = 2e-49
Identities = 92/142 (64%), Positives = 113/142 (79%)
Frame = +1
Query: 1 VNAAGTFNMIRLCCSMFNSNEPNEFNQRGIVINTSSIAAFEGQCGQSAYSASQGAIVAMT 180
VN GTFN+IRL + NEP++ QRG++INT+S+AAFEGQ GQ+AYSAS+G IV MT
Sbjct: 120 VNLIGTFNVIRLVAGVMGQNEPDQGGQRGVIINTASVAAFEGQVGQAAYSASKGGIVGMT 179
Query: 181 LPLARDLVAMGVRVMTIAPGIFLTPLLENVPDSARLNLSKIVPFPSRLGHPDEFAHLVQS 360
LP+ARDL +G+RV+TIAPG+F TPLL +PD R L+ VPFPSRLG P E+AHLVQ
Sbjct: 180 LPIARDLAPIGIRVVTIAPGLFATPLLTTLPDKVRNFLASQVPFPSRLGDPAEYAHLVQM 239
Query: 361 IIENPMLNGEVIRIDGALRMMP 426
+IENP LNGEVIR+DGA+RM P
Sbjct: 240 VIENPFLNGEVIRLDGAIRMQP 261
>sp|O02691|HCD2_BOVIN 3-hydroxyacyl-CoA dehydrogenase type II (Type II HADH)
Length = 261
Score = 192 bits (487), Expect = 5e-49
Identities = 94/142 (66%), Positives = 112/142 (78%)
Frame = +1
Query: 1 VNAAGTFNMIRLCCSMFNSNEPNEFNQRGIVINTSSIAAFEGQCGQSAYSASQGAIVAMT 180
VN GTFN+IRL NEP++ QRG++INT+S+AAFEGQ GQ+AYSAS+G IV MT
Sbjct: 120 VNLIGTFNVIRLVAGEMGQNEPDQGGQRGVIINTASVAAFEGQVGQAAYSASKGGIVGMT 179
Query: 181 LPLARDLVAMGVRVMTIAPGIFLTPLLENVPDSARLNLSKIVPFPSRLGHPDEFAHLVQS 360
LP+ARDL MG+RVMTIAPG+F TPLL +PD R L+ VPFPSRLG P E+AHLVQ+
Sbjct: 180 LPIARDLAPMGIRVMTIAPGLFGTPLLTTLPDKVRNFLASQVPFPSRLGDPAEYAHLVQA 239
Query: 361 IIENPMLNGEVIRIDGALRMMP 426
IIEN LNGEVIR+DGA+RM P
Sbjct: 240 IIENSFLNGEVIRLDGAIRMQP 261
>sp|Q99714|HCD2_HUMAN 3-hydroxyacyl-CoA dehydrogenase type II (Type II HADH) (Endoplasmic
reticulum-associated amyloid beta-peptide binding
protein) (Short-chain type dehydrogenase/reductase
XH98G2)
Length = 261
Score = 189 bits (480), Expect = 3e-48
Identities = 92/142 (64%), Positives = 113/142 (79%)
Frame = +1
Query: 1 VNAAGTFNMIRLCCSMFNSNEPNEFNQRGIVINTSSIAAFEGQCGQSAYSASQGAIVAMT 180
VN GTFN+IRL NEP++ QRG++INT+S+AAFEGQ GQ+AYSAS+G IV MT
Sbjct: 120 VNLMGTFNVIRLVAGEMGQNEPDQGGQRGVIINTASVAAFEGQVGQAAYSASKGGIVGMT 179
Query: 181 LPLARDLVAMGVRVMTIAPGIFLTPLLENVPDSARLNLSKIVPFPSRLGHPDEFAHLVQS 360
LP+ARDL +G+RVMTIAPG+F TPLL ++P+ L+ VPFPSRLG P E+AHLVQ+
Sbjct: 180 LPIARDLAPIGIRVMTIAPGLFGTPLLTSLPEKVCNFLASQVPFPSRLGDPAEYAHLVQA 239
Query: 361 IIENPMLNGEVIRIDGALRMMP 426
IIENP LNGEVIR+DGA+RM P
Sbjct: 240 IIENPFLNGEVIRLDGAIRMQP 261
>sp|O08756|HCD2_MOUSE 3-hydroxyacyl-CoA dehydrogenase type II (Type II HADH) (Endoplasmic
reticulum-associated amyloid beta-peptide binding
protein)
Length = 261
Score = 188 bits (477), Expect = 6e-48
Identities = 91/142 (64%), Positives = 111/142 (78%)
Frame = +1
Query: 1 VNAAGTFNMIRLCCSMFNSNEPNEFNQRGIVINTSSIAAFEGQCGQSAYSASQGAIVAMT 180
VN GTFN+IRL NEP++ QRG++INT+S+AAFEGQ GQ+AYSAS+G I MT
Sbjct: 120 VNLIGTFNVIRLVAGEMGQNEPDQGGQRGVIINTASVAAFEGQVGQAAYSASKGGIDGMT 179
Query: 181 LPLARDLVAMGVRVMTIAPGIFLTPLLENVPDSARLNLSKIVPFPSRLGHPDEFAHLVQS 360
LP+ARDL G+RV+TIAPG+F TPLL +P+ R L+ VPFPSRLG P E+AHLVQ+
Sbjct: 180 LPIARDLAPTGIRVVTIAPGLFATPLLTTLPEKVRNFLASQVPFPSRLGDPAEYAHLVQT 239
Query: 361 IIENPMLNGEVIRIDGALRMMP 426
IIENP LNGEVIR+DGA+RM P
Sbjct: 240 IIENPFLNGEVIRLDGAIRMQP 261
>sp|Q9X248|FABG_THEMA 3-oxoacyl-[acyl-carrier-protein] reductase (3-ketoacyl-acyl carrier
protein reductase)
Length = 246
Score = 79.3 bits (194), Expect = 4e-15
Identities = 47/141 (33%), Positives = 73/141 (51%), Gaps = 3/141 (2%)
Frame = +1
Query: 1 VNAAGTFNMIRLCCSMFNSNEPNEFNQR-GIVINTSSIAAFEGQCGQSAYSASQGAIVAM 177
VN G FN+ ++ P QR G ++N SS+ G GQ+ Y+AS+ ++ M
Sbjct: 112 VNLKGVFNVTQMVV-------PYMIKQRNGSIVNVSSVVGIYGNPGQTNYAASKAGVIGM 164
Query: 178 TLPLARDLVAMGVRVMTIAPGIFLTPLLENVPDSARLNLSKIVPFPSRLGHPDEFAHLVQ 357
T A++L +RV +APG TP+ E +P+ AR +P R G P+E A ++
Sbjct: 165 TKTWAKELAGRNIRVNAVAPGFIETPMTEKLPEKARETALSRIPL-GRFGKPEEVAQVIL 223
Query: 358 SII--ENPMLNGEVIRIDGAL 414
+ E+ + G+VI IDG L
Sbjct: 224 FLASDESSYVTGQVIGIDGGL 244
>sp|Q92506|DHB8_HUMAN Estradiol 17-beta-dehydrogenase 8 (17-beta-HSD 8)
(17-beta-hydroxysteroid dehydrogenase 8) (Protein Ke6)
(Ke-6)
Length = 261
Score = 69.7 bits (169), Expect = 3e-12
Identities = 42/142 (29%), Positives = 71/142 (50%), Gaps = 2/142 (1%)
Frame = +1
Query: 1 VNAAGTFNMIRLCCSMFNSNEPNEFNQRGIVINTSSIAAFEGQCGQSAYSASQGAIVAMT 180
VN GTF + + SN RG +IN SSI G GQ+ Y+AS+ ++ +T
Sbjct: 126 VNLKGTFLVTQAAAQALVSN-----GCRGSIINISSIVGKVGNVGQTNYAASKAGVIGLT 180
Query: 181 LPLARDLVAMGVRVMTIAPGIFLTPLLENVPDSARLNLSKIVPFPSRLGHPDEFAHLVQS 360
AR+L G+R ++ PG TP+ + VP +++++P LG P++ A +V
Sbjct: 181 QTAARELGRHGIRCNSVLPGFIATPMTQKVPQKVVDKITEMIPM-GHLGDPEDVADVVAF 239
Query: 361 II--ENPMLNGEVIRIDGALRM 420
+ ++ + G + + G L M
Sbjct: 240 LASEDSGYITGTSVEVTGGLFM 261
>sp|P28643|FABG_CUPLA 3-oxoacyl-[acyl-carrier-protein] reductase, chloroplast precursor
(3-ketoacyl-acyl carrier protein reductase)
Length = 320
Score = 67.4 bits (163), Expect = 2e-11
Identities = 34/117 (29%), Positives = 61/117 (52%), Gaps = 3/117 (2%)
Frame = +1
Query: 79 QRGIVINTSSIAAFEGQCGQSAYSASQGAIVAMTLPLARDLVAMGVRVMTIAPGIFLTPL 258
++G +IN +S+ G GQ+ YSA++ ++ T +AR+ + + V +APG + +
Sbjct: 205 KKGRIINIASVVGLVGNAGQANYSAAKAGVIGFTKTVAREYASRNINVNAVAPGFISSDM 264
Query: 259 LENVPDSARLNLSKIVPFPSRLGHPDEFAHLVQSIIENP---MLNGEVIRIDGALRM 420
+ D + + +P R G P+E A LV+ + NP + G+V IDG + M
Sbjct: 265 TSKLGDDINKKILETIPL-GRYGQPEEVAGLVEFLAINPASSYVTGQVFTIDGGMTM 320
>sp|P50171|DHB8_MOUSE Estradiol 17-beta-dehydrogenase 8 (17-beta-HSD 8)
(17-beta-hydroxysteroid dehydrogenase 8) (Protein Ke6)
(Ke-6)
Length = 260
Score = 66.6 bits (161), Expect = 3e-11
Identities = 38/142 (26%), Positives = 72/142 (50%), Gaps = 2/142 (1%)
Frame = +1
Query: 1 VNAAGTFNMIRLCCSMFNSNEPNEFNQRGIVINTSSIAAFEGQCGQSAYSASQGAIVAMT 180
VN GTF + + S+ RG +IN SSI G GQ+ Y++S+ ++ +T
Sbjct: 125 VNLKGTFLVTQAAAQALVSS-----GGRGSIINISSIIGKVGNIGQTNYASSKAGVIGLT 179
Query: 181 LPLARDLVAMGVRVMTIAPGIFLTPLLENVPDSARLNLSKIVPFPSRLGHPDEFAHLVQS 360
AR+L G+R ++ PG TP+ + +P+ + ++ ++P +G P++ A +V
Sbjct: 180 QTAARELGRHGIRCNSVLPGFIATPMTQKMPEKVKDKVTAMIPL-GHMGDPEDVADVVAF 238
Query: 361 II--ENPMLNGEVIRIDGALRM 420
+ ++ + G + + G L M
Sbjct: 239 LASEDSGYITGASVEVSGGLFM 260
>sp|P66781|YD50_MYCTU Putative oxidoreductase Rv1350/MT1393
sp|P66782|YD85_MYCBO Putative oxidoreductase Mb1385
Length = 247
Score = 66.2 bits (160), Expect = 4e-11
Identities = 43/139 (30%), Positives = 71/139 (51%), Gaps = 3/139 (2%)
Frame = +1
Query: 1 VNAAGTFNMIRLCCSMFNSNEPNEFNQRGIVINTSSIAAFEGQCGQSAYSASQGAIVAMT 180
V+ GT+N RL ++ + RG ++N SS++ G GQ+ YSA++ IV MT
Sbjct: 113 VHLKGTWNGTRLAAAIMRERK------RGAIVNMSSVSGKVGMVGQTNYSAAKAGIVGMT 166
Query: 181 LPLARDLVAMGVRVMTIAPGIFLTPLLENVPDSARLNLSKIVPFP-SRLGHPDEFAHLVQ 357
A++L +G+RV IAPG+ + + E +P R+ K+ P R G P E A +
Sbjct: 167 KAAAKELAHLGIRVNAIAPGLIRSAMTEAMPQ--RIWDQKLAEVPMGRAGEPSEVASVAV 224
Query: 358 SIIE--NPMLNGEVIRIDG 408
+ + + G V+ + G
Sbjct: 225 FLASDLSSYMTGTVLDVTG 243
Database: Non-redundant SwissProt sequences
Posted date: Dec 6, 2005 7:40 AM
Number of letters in database: 68,354,980
Number of sequences in database: 184,735
Database: swissprot.01
Posted date: Dec 6, 2005 8:18 AM
Number of letters in database: 66,202,850
Number of sequences in database: 184,431
Lambda K H
0.318 0.134 0.401
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 56,797,482
Number of Sequences: 369166
Number of extensions: 1096892
Number of successful extensions: 3670
Number of sequences better than 10.0: 10
Number of HSP's better than 10.0 without gapping: 3581
Number of HSP's successfully gapped in prelim test: 0
Number of HSP's that attempted gapping in prelim test: 0
Number of HSP's gapped (non-prelim): 3663
length of database: 68,354,980
effective HSP length: 102
effective length of database: 49,512,010
effective search space used: 2921208590
frameshift window, decay const: 40, 0.1
T: 12
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)