Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= Dr_sW_007_A18
(623 letters)
Database: Non-redundant SwissProt sequences
184,735 sequences; 68,354,980 total letters
Score E
Sequences producing significant alignments: (bits) Value
sp|Q95029|CATL_DROME Cathepsin L precursor (Cysteine protei... 205 7e-53
sp|Q26636|CATL_SARPE Cathepsin L precursor [Contains: Cathe... 204 1e-52
sp|Q10991|CATL_SHEEP Cathepsin L [Contains: Cathepsin L hea... 200 3e-51
sp|P07711|CATL_HUMAN Cathepsin L precursor (Major excreted ... 199 5e-51
sp|P25784|CYSP3_HOMAM Digestive cysteine proteinase 3 precu... 198 1e-50
sp|P25782|CYSP2_HOMAM Digestive cysteine proteinase 2 precu... 197 1e-50
sp|P25975|CATL_BOVIN Cathepsin L precursor [Contains: Cathe... 195 7e-50
sp|O60911|CATL2_HUMAN Cathepsin L2 precursor (Cathepsin V) ... 195 9e-50
sp|Q9GL24|CATL_CANFA Cathepsin L precursor [Contains: Cathe... 194 2e-49
sp|P13277|CYSP1_HOMAM Digestive cysteine proteinase 1 precu... 190 3e-48
>sp|Q95029|CATL_DROME Cathepsin L precursor (Cysteine proteinase 1) [Contains: Cathepsin
L heavy chain; Cathepsin L light chain]
Length = 341
Score = 205 bits (522), Expect = 7e-53
Identities = 101/179 (56%), Positives = 122/179 (68%), Gaps = 2/179 (1%)
Frame = +2
Query: 2 SLEGQYFRKNNRLISFSEQQLVDCSXXXXXXXXXXXLMDNAFRYIKDQG-IESEGDYPYT 178
+LEGQ+FRK+ L+S SEQ LVDCS LMDNAFRYIKD G I++E YPY
Sbjct: 156 ALEGQHFRKSGVLVSLSEQNLVDCSTKYGNNGCNGGLMDNAFRYIKDNGGIDTEKSYPYE 215
Query: 179 ATDGTCKRNPSKIVTKCTGFTDIQSQNETDLANAVATVGPVSVAIDAGHASFQLYKSGIY 358
A D +C N + GFTDI +E +A AVATVGPVSVAIDA H SFQ Y G+Y
Sbjct: 216 AIDDSCHFNKGTVGATDRGFTDIPQGDEKKMAEAVATVGPVSVAIDASHESFQFYSEGVY 275
Query: 359 NEESCSTTQLDHGVLAVGYGT-QIGKKYWIVKNSWDVTWGESGYIKMSKDKKNQCGIAN 532
NE C LDHGVL VG+GT + G+ YW+VKNSW TWG+ G+IKM ++K+NQCGIA+
Sbjct: 276 NEPQCDAQNLDHGVLVVGFGTDESGEDYWLVKNSWGTTWGDKGFIKMLRNKENQCGIAS 334
>sp|Q26636|CATL_SARPE Cathepsin L precursor [Contains: Cathepsin L heavy chain; Cathepsin
L light chain]
Length = 339
Score = 204 bits (519), Expect = 1e-52
Identities = 102/178 (57%), Positives = 119/178 (66%), Gaps = 2/178 (1%)
Frame = +2
Query: 2 SLEGQYFRKNNRLISFSEQQLVDCSXXXXXXXXXXXLMDNAFRYIKDQG-IESEGDYPYT 178
+LEGQ+FRK L+S SEQ LVDCS LMDNAFRYIKD G I++E YPY
Sbjct: 154 ALEGQHFRKAGVLVSLSEQNLVDCSTKYGNNGCNGGLMDNAFRYIKDNGGIDTEKSYPYE 213
Query: 179 ATDGTCKRNPSKIVTKCTGFTDIQSQNETDLANAVATVGPVSVAIDAGHASFQLYKSGIY 358
D +C N + I TGF DI +E + AVAT+GPVSVAIDA H SFQLY G+Y
Sbjct: 214 GIDDSCHFNKATIGATDTGFVDIPEGDEEKMKKAVATMGPVSVAIDASHESFQLYSEGVY 273
Query: 359 NEESCSTTQLDHGVLAVGYGT-QIGKKYWIVKNSWDVTWGESGYIKMSKDKKNQCGIA 529
NE C LDHGVL VGYGT + G YW+VKNSW TWGE GYIKM++++ NQCGIA
Sbjct: 274 NEPECDEQNLDHGVLVVGYGTDESGMDYWLVKNSWGTTWGEQGYIKMARNQNNQCGIA 331
>sp|Q10991|CATL_SHEEP Cathepsin L [Contains: Cathepsin L heavy chain; Cathepsin L light
chain]
Length = 217
Score = 200 bits (508), Expect = 3e-51
Identities = 102/178 (57%), Positives = 119/178 (66%), Gaps = 2/178 (1%)
Frame = +2
Query: 2 SLEGQYFRKNNRLISFSEQQLVDCSXXXXXXXXXXXLMDNAFRYIKDQG-IESEGDYPYT 178
+LEGQ FRK +L+S SEQ LVD S LMDNAF+YIK+ G ++SE YPY
Sbjct: 33 ALEGQMFRKTGKLVSLSEQNLVDSSRPQGNQGCNGGLMDNAFQYIKENGGLDSEESYPYE 92
Query: 179 ATDGTCKRNPSKIVTKCTGFTDIQSQNETDLANAVATVGPVSVAIDAGHASFQLYKSGIY 358
ATD +C P K TGF DI Q E L AVATVGP+SVAIDAGH+SFQ YKSGIY
Sbjct: 93 ATDTSCNYKPEYSAAKDTGFVDIP-QREKALMKAVATVGPISVAIDAGHSSFQFYKSGIY 151
Query: 359 NEESCSTTQLDHGVLAVGYGTQ-IGKKYWIVKNSWDVTWGESGYIKMSKDKKNQCGIA 529
+ CS+ LDHGVL VGYG + K+WIVKNSW WG GY+KM+KD+ N CGIA
Sbjct: 152 YDPDCSSKDLDHGVLVVGYGFEGTNNKFWIVKNSWGPEWGNKGYVKMAKDQNNHCGIA 209
>sp|P07711|CATL_HUMAN Cathepsin L precursor (Major excreted protein) (MEP) [Contains:
Cathepsin L heavy chain; Cathepsin L light chain]
Length = 333
Score = 199 bits (506), Expect = 5e-51
Identities = 102/182 (56%), Positives = 120/182 (65%), Gaps = 5/182 (2%)
Frame = +2
Query: 2 SLEGQYFRKNNRLISFSEQQLVDCSXXXXXXXXXXXLMDNAFRYIKDQG-IESEGDYPYT 178
+LEGQ FRK RLIS SEQ LVDCS LMD AF+Y++D G ++SE YPY
Sbjct: 146 ALEGQMFRKTGRLISLSEQNLVDCSGPQGNEGCNGGLMDYAFQYVQDNGGLDSEESYPYE 205
Query: 179 ATDGTCKRNPSKIVTKCTGFTDIQSQNETDLANAVATVGPVSVAIDAGHASFQLYKSGIY 358
AT+ +CK NP V TGF DI Q E L AVATVGP+SVAIDAGH SF YK GIY
Sbjct: 206 ATEESCKYNPKYSVANDTGFVDIPKQ-EKALMKAVATVGPISVAIDAGHESFLFYKEGIY 264
Query: 359 NEESCSTTQLDHGVLAVGYGTQI----GKKYWIVKNSWDVTWGESGYIKMSKDKKNQCGI 526
E CS+ +DHGVL VGYG + KYW+VKNSW WG GY+KM+KD++N CGI
Sbjct: 265 FEPDCSSEDMDHGVLVVGYGFESTESDNNKYWLVKNSWGEEWGMGGYVKMAKDRRNHCGI 324
Query: 527 AN 532
A+
Sbjct: 325 AS 326
>sp|P25784|CYSP3_HOMAM Digestive cysteine proteinase 3 precursor
Length = 321
Score = 198 bits (503), Expect = 1e-50
Identities = 97/179 (54%), Positives = 125/179 (69%), Gaps = 1/179 (0%)
Frame = +2
Query: 2 SLEGQYFRKNNRLISFSEQQLVDCSXXXXXXXXXXXLMDNAFRYIKDQG-IESEGDYPYT 178
+LEGQ+F KN+ L+S SEQQLVDCS M +AF YIKD G I++E YPY
Sbjct: 138 ALEGQHFLKNDELVSLSEQQLVDCSTDYGNDGCGGGWMTSAFDYIKDNGGIDTESSYPYE 197
Query: 179 ATDGTCKRNPSKIVTKCTGFTDIQSQNETDLANAVATVGPVSVAIDAGHASFQLYKSGIY 358
A D +C+ + + I CTG ++Q E L AV+ VGP+SVAIDA H SFQ Y SG+Y
Sbjct: 198 AEDRSCRFDANSIGAICTGSVEVQHTEEA-LQEAVSGVGPISVAIDASHFSFQFYSSGVY 256
Query: 359 NEESCSTTQLDHGVLAVGYGTQIGKKYWIVKNSWDVTWGESGYIKMSKDKKNQCGIAND 535
E++CS T LDHGVLAVGYGT+ K YW+VKNSW +WG++GYIKMS+++ N CGIA++
Sbjct: 257 YEQNCSPTFLDHGVLAVGYGTESTKDYWLVKNSWGSSWGDAGYIKMSRNRDNNCGIASE 315
>sp|P25782|CYSP2_HOMAM Digestive cysteine proteinase 2 precursor
Length = 323
Score = 197 bits (502), Expect = 1e-50
Identities = 93/177 (52%), Positives = 124/177 (70%), Gaps = 1/177 (0%)
Frame = +2
Query: 2 SLEGQYFRKNNRLISFSEQQLVDCSXXXXXXXXXXXLMDNAFRYIK-DQGIESEGDYPYT 178
SLEGQ+F K LIS +EQQLVDCS M++AF YIK + GI++E YPY
Sbjct: 139 SLEGQHFLKTGSLISLAEQQLVDCSRPYGPQGCNGGWMNDAFDYIKANNGIDTEAAYPYE 198
Query: 179 ATDGTCKRNPSKIVTKCTGFTDIQSQNETDLANAVATVGPVSVAIDAGHASFQLYKSGIY 358
A DG+C+ + + + C+G T+I S +ET L AV +GP+SV IDA H+SFQ Y SG+Y
Sbjct: 199 ARDGSCRFDSNSVAATCSGHTNIASGSETGLQQAVRDIGPISVTIDAAHSSFQFYSSGVY 258
Query: 359 NEESCSTTQLDHGVLAVGYGTQIGKKYWIVKNSWDVTWGESGYIKMSKDKKNQCGIA 529
E SCS + LDH VLAVGYG++ G+ +W+VKNSW +WG++GYIKMS+++ N CGIA
Sbjct: 259 YEPSCSPSYLDHAVLAVGYGSEGGQDFWLVKNSWATSWGDAGYIKMSRNRNNNCGIA 315
>sp|P25975|CATL_BOVIN Cathepsin L precursor [Contains: Cathepsin L heavy chain; Cathepsin
L light chain]
Length = 334
Score = 195 bits (496), Expect = 7e-50
Identities = 103/182 (56%), Positives = 118/182 (64%), Gaps = 6/182 (3%)
Frame = +2
Query: 2 SLEGQYFRKNNRLISFSEQQLVDCSXXXXXXXXXXXLMDNAFRYIKDQG-IESEGDYPYT 178
+LEGQ FRK +L+S SEQ LVDCS LMDNAF+YIKD G ++SE YPY
Sbjct: 146 ALEGQMFRKTGKLVSLSEQNLVDCSRAQGNQGCNGGLMDNAFQYIKDNGGLDSEESYPYL 205
Query: 179 ATD-GTCKRNPSKIVTKCTGFTDIQSQNETDLANAVATVGPVSVAIDAGHASFQLYKSGI 355
ATD +C P TGF DI Q E L AVATVGP+SVAIDAGH SFQ YKSGI
Sbjct: 206 ATDTNSCNYKPECSAANDTGFVDIP-QREKALMKAVATVGPISVAIDAGHTSFQFYKSGI 264
Query: 356 YNEESCSTTQLDHGVLAVGYGTQ----IGKKYWIVKNSWDVTWGESGYIKMSKDKKNQCG 523
Y + CS LDHGVL VGYG + K+WIVKNSW WG +GY+KM+KD+ N CG
Sbjct: 265 YYDPDCSCKDLDHGVLVVGYGFEGTDSNNNKFWIVKNSWGPEWGWNGYVKMAKDQNNHCG 324
Query: 524 IA 529
IA
Sbjct: 325 IA 326
>sp|O60911|CATL2_HUMAN Cathepsin L2 precursor (Cathepsin V) (Cathepsin U)
Length = 334
Score = 195 bits (495), Expect = 9e-50
Identities = 97/181 (53%), Positives = 115/181 (63%), Gaps = 5/181 (2%)
Frame = +2
Query: 2 SLEGQYFRKNNRLISFSEQQLVDCSXXXXXXXXXXXLMDNAFRYIKDQG-IESEGDYPYT 178
+LEGQ FRK +L+S SEQ LVDCS M AF+Y+K+ G ++SE YPY
Sbjct: 146 ALEGQMFRKTGKLVSLSEQNLVDCSRPQGNQGCNGGFMARAFQYVKENGGLDSEESYPYV 205
Query: 179 ATDGTCKRNPSKIVTKCTGFTDIQSQNETDLANAVATVGPVSVAIDAGHASFQLYKSGIY 358
A D CK P V TGFT + E L AVATVGP+SVA+DAGH+SFQ YKSGIY
Sbjct: 206 AVDEICKYRPENSVANDTGFTVVAPGKEKALMKAVATVGPISVAMDAGHSSFQFYKSGIY 265
Query: 359 NEESCSTTQLDHGVLAVGYG----TQIGKKYWIVKNSWDVTWGESGYIKMSKDKKNQCGI 526
E CS+ LDHGVL VGYG KYW+VKNSW WG +GY+K++KDK N CGI
Sbjct: 266 FEPDCSSKNLDHGVLVVGYGFEGANSNNSKYWLVKNSWGPEWGSNGYVKIAKDKNNHCGI 325
Query: 527 A 529
A
Sbjct: 326 A 326
>sp|Q9GL24|CATL_CANFA Cathepsin L precursor [Contains: Cathepsin L heavy chain; Cathepsin
L light chain]
Length = 333
Score = 194 bits (493), Expect = 2e-49
Identities = 101/181 (55%), Positives = 117/181 (64%), Gaps = 5/181 (2%)
Frame = +2
Query: 2 SLEGQYFRKNNRLISFSEQQLVDCSXXXXXXXXXXXLMDNAFRYIKDQG-IESEGDYPYT 178
+LEGQ FRK +L+S SEQ LVDCS LMDNAFRY+KD G ++SE YPY
Sbjct: 146 ALEGQMFRKTGKLVSLSEQNLVDCSRAQGNEGCNGGLMDNAFRYVKDNGGLDSEESYPYL 205
Query: 179 ATDG-TCKRNPSKIVTKCTGFTDIQSQNETDLANAVATVGPVSVAIDAGHASFQLYKSGI 355
D TC P TGF D+ Q E L AVAT+GP+SVAIDAGH SFQ YKSGI
Sbjct: 206 GRDTETCNYKPECSAANDTGFVDLP-QREKALMKAVATLGPISVAIDAGHQSFQFYKSGI 264
Query: 356 YNEESCSTTQLDHGVLAVGY---GTQIGKKYWIVKNSWDVTWGESGYIKMSKDKKNQCGI 526
Y + CS+ LDHGVL VGY GT K+WIVKNSW WG +GY+KM+KD+ N CGI
Sbjct: 265 YFDPDCSSKDLDHGVLVVGYGFEGTDSNNKFWIVKNSWGPEWGWNGYVKMAKDQNNHCGI 324
Query: 527 A 529
A
Sbjct: 325 A 325
>sp|P13277|CYSP1_HOMAM Digestive cysteine proteinase 1 precursor
Length = 322
Score = 190 bits (482), Expect = 3e-48
Identities = 89/179 (49%), Positives = 121/179 (67%), Gaps = 2/179 (1%)
Frame = +2
Query: 5 LEGQYFRKNNRLISFSEQQLVDCSXXXXXXXXXXX-LMDNAFRYIKDQG-IESEGDYPYT 178
+EGQ+F K RL+S SEQQLVDC+ ++ A Y++D G +++E YPY
Sbjct: 138 IEGQHFLKTGRLVSLSEQQLVDCAGGSYYNQGCNGGWVERAIMYVRDNGGVDTESSYPYE 197
Query: 179 ATDGTCKRNPSKIVTKCTGFTDIQSQNETDLANAVATVGPVSVAIDAGHASFQLYKSGIY 358
A D TC+ N + I CTG+ I +E+ L A +GP+SVAIDA H SFQ Y +G+Y
Sbjct: 198 ARDNTCRFNSNTIGATCTGYVGIAQGSESALKTATRDIGPISVAIDASHRSFQSYYTGVY 257
Query: 359 NEESCSTTQLDHGVLAVGYGTQIGKKYWIVKNSWDVTWGESGYIKMSKDKKNQCGIAND 535
E SCS++QLDH VLAVGYG++ G+ +W+VKNSW +WGESGYIKM++++ N CGIA D
Sbjct: 258 YEPSCSSSQLDHAVLAVGYGSEGGQDFWLVKNSWATSWGESGYIKMARNRNNNCGIATD 316
Database: Non-redundant SwissProt sequences
Posted date: Dec 6, 2005 7:40 AM
Number of letters in database: 68,354,980
Number of sequences in database: 184,735
Database: swissprot.01
Posted date: Dec 6, 2005 8:18 AM
Number of letters in database: 66,202,850
Number of sequences in database: 184,431
Lambda K H
0.318 0.134 0.401
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 67,046,417
Number of Sequences: 369166
Number of extensions: 1301136
Number of successful extensions: 3971
Number of sequences better than 10.0: 10
Number of HSP's better than 10.0 without gapping: 3515
Number of HSP's successfully gapped in prelim test: 0
Number of HSP's that attempted gapping in prelim test: 0
Number of HSP's gapped (non-prelim): 3590
length of database: 68,354,980
effective HSP length: 106
effective length of database: 48,773,070
effective search space used: 4926080070
frameshift window, decay const: 40, 0.1
T: 12
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)