Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= Dr_sW_006_P23
(772 letters)
Database: Non-redundant SwissProt sequences
184,735 sequences; 68,354,980 total letters
Score E
Sequences producing significant alignments: (bits) Value
sp|Q9V3D2|HEM6_DROME Coproporphyrinogen III oxidase (Coprop... 251 2e-66
sp|P36552|HEM6_MOUSE Coproporphyrinogen III oxidase, mitoch... 244 2e-64
sp|P36551|HEM6_HUMAN Coproporphyrinogen III oxidase, mitoch... 243 5e-64
sp|Q9UTE2|HEM6_SCHPO Probable coproporphyrinogen III oxidas... 216 5e-56
sp|Q9LR75|HEM6_ARATH Coproporphyrinogen III oxidase, chloro... 214 3e-55
sp|P35055|HEM6_SOYBN Coproporphyrinogen III oxidase, chloro... 210 3e-54
sp|Q42946|HEM6_TOBAC Coproporphyrinogen III oxidase, chloro... 202 8e-52
sp|Q42840|HEM6_HORVU Coproporphyrinogen III oxidase, chloro... 201 2e-51
sp|Q8YX58|HEM62_ANASP Coproporphyrinogen III oxidase, aerob... 190 4e-48
sp|P11353|HEM6_YEAST Coproporphyrinogen III oxidase (Coprop... 189 9e-48
>sp|Q9V3D2|HEM6_DROME Coproporphyrinogen III oxidase (Coproporphyrinogenase) (Coprogen
oxidase) (COX)
Length = 390
Score = 251 bits (640), Expect = 2e-66
Identities = 120/229 (52%), Positives = 157/229 (68%), Gaps = 11/229 (4%)
Frame = +1
Query: 118 ELIDPEI---------WMSEPVTEKSELL-KSSSYRAKMEKLCLQVQGELCRSMERIDGK 267
E +DP++ +M+EP+T+ LL + R +ME L +++Q E CR++E +
Sbjct: 51 EAVDPKVNGVQMNTSRFMAEPITDSKALLGDKENMRHRMEILIMEIQAEFCRALEAEENC 110
Query: 268 A-KFLVDKWNRKAGGGGVTCVISDGNVFEKAGVNISAIHGSLTKQAVIQMKARLTDLNEQ 444
KF VD+W R GGGG+TCV+ DG+VFEKAGVNIS + GSL AV QM+AR +L E
Sbjct: 111 GQKFKVDRWERPEGGGGITCVLQDGDVFEKAGVNISVVTGSLPPAAVQQMRARGKNLKEG 170
Query: 445 LDYKFFACGISSVIHPSNPHVPACHFNFRYFELEKPHGERVWWFGGGSDLTPNFLVEEDV 624
FFA G+S+VIHP NPHVP HFN+RYFE+E GE+ WWFGGG+DLTP +L E+D
Sbjct: 171 ASLPFFASGVSAVIHPRNPHVPTIHFNYRYFEVETAKGEKQWWFGGGTDLTPYYLCEKDA 230
Query: 625 IHFHSTLKQACDLHDPNFYPRYKEWCDRYFFYCSSK*KTRELGGIFFDD 771
HFH TLK ACD HDP +YPR+K+WCD Y F + ++R +GGIFFDD
Sbjct: 231 SHFHQTLKSACDEHDPTYYPRFKKWCDDY-FRIKHRNESRGIGGIFFDD 278
>sp|P36552|HEM6_MOUSE Coproporphyrinogen III oxidase, mitochondrial precursor
(Coproporphyrinogenase) (Coprogen oxidase) (COX)
Length = 443
Score = 244 bits (622), Expect = 2e-64
Identities = 113/214 (52%), Positives = 152/214 (71%), Gaps = 3/214 (1%)
Frame = +1
Query: 139 WMSEPVTEKSELLKS-SSYRAKMEKLCLQVQGELCRSMERIDGKAKFLVDKWNRKAGGGG 315
+MS PVTE EL + + KME + ++ Q ++CR++ ++DG A F VD+W RK GGGG
Sbjct: 119 FMSSPVTELRELRRRPEDMKTKMELMIMETQAQVCRALAQVDGVADFTVDRWERKEGGGG 178
Query: 316 VTCVISDGNVFEKAGVNISAIHGSLTKQAVIQMKARLTDLNEQLDYK--FFACGISSVIH 489
+TCV+ DG VFEKAGV+IS +HG+L+++A QM+ R L + D K F A G+SSVIH
Sbjct: 179 ITCVLQDGRVFEKAGVSISVVHGNLSEEAANQMRGRGKTLKTK-DSKLPFTAMGVSSVIH 237
Query: 490 PSNPHVPACHFNFRYFELEKPHGERVWWFGGGSDLTPNFLVEEDVIHFHSTLKQACDLHD 669
P NP+ P HFN+RYFE+E+ G WWFGGG DLTP +L +ED +HFH TLK+ACD H
Sbjct: 238 PKNPYAPTMHFNYRYFEVEEADGNTHWWFGGGCDLTPTYLNQEDAVHFHRTLKEACDQHG 297
Query: 670 PNFYPRYKEWCDRYFFYCSSK*KTRELGGIFFDD 771
P+ YP++K+WCD YFF + + R +GGIFFDD
Sbjct: 298 PDIYPKFKKWCDDYFFIV-HRGERRGIGGIFFDD 330
>sp|P36551|HEM6_HUMAN Coproporphyrinogen III oxidase, mitochondrial precursor
(Coproporphyrinogenase) (Coprogen oxidase) (COX)
Length = 454
Score = 243 bits (619), Expect = 5e-64
Identities = 112/214 (52%), Positives = 155/214 (72%), Gaps = 3/214 (1%)
Frame = +1
Query: 139 WMSEPVTEKSELLKS-SSYRAKMEKLCLQVQGELCRSMERIDGKAKFLVDKWNRKAGGGG 315
+M+ PVT+ EL + + KME L L+ Q ++C+++ ++DG A F VD+W RK GGGG
Sbjct: 130 FMAPPVTDLGELRRRPGDMKTKMELLILETQAQVCQALAQVDGGANFSVDRWERKEGGGG 189
Query: 316 VTCVISDGNVFEKAGVNISAIHGSLTKQAVIQMKARLTDLNEQLDYK--FFACGISSVIH 489
++CV+ DG VFEKAGV+IS +HG+L+++A QM++R L + D K F A G+SSVIH
Sbjct: 190 ISCVLQDGCVFEKAGVSISVVHGNLSEEAAKQMRSRGKVLKTK-DGKLPFCAMGVSSVIH 248
Query: 490 PSNPHVPACHFNFRYFELEKPHGERVWWFGGGSDLTPNFLVEEDVIHFHSTLKQACDLHD 669
P NPH P HFN+RYFE+E+ G + WWFGGG DLTP +L +ED +HFH TLK+ACD H
Sbjct: 249 PKNPHAPTIHFNYRYFEVEEADGNKQWWFGGGCDLTPTYLNQEDAVHFHRTLKEACDQHG 308
Query: 670 PNFYPRYKEWCDRYFFYCSSK*KTRELGGIFFDD 771
P+ YP++K+WCD YFF + + + R +GGIFFDD
Sbjct: 309 PDLYPKFKKWCDDYFF-IAHRGERRGIGGIFFDD 341
>sp|Q9UTE2|HEM6_SCHPO Probable coproporphyrinogen III oxidase (Coproporphyrinogenase)
(Coprogen oxidase) (COX)
Length = 312
Score = 216 bits (550), Expect = 5e-56
Identities = 103/192 (53%), Positives = 129/192 (67%), Gaps = 1/192 (0%)
Frame = +1
Query: 199 KMEKLCLQVQGELCRSMERIDGKAKFLVDKWNRKAGGGGVTCVISDGNVFEKAGVNISAI 378
+MEKL L VQ E+ +E +DG+ KF DKW + GG G++CVI DGNVFEK GVN S +
Sbjct: 12 QMEKLILDVQQEIVAGLEAVDGQ-KFFQDKWTKGEGGYGISCVIQDGNVFEKGGVNTSIV 70
Query: 379 HGSLTKQAVIQMKARLTDLNEQL-DYKFFACGISSVIHPSNPHVPACHFNFRYFELEKPH 555
G L + AV +M+A ++ + FFA GIS VIHP NP P H N+RYFEL
Sbjct: 71 QGKLNQDAVQRMRANHEGIDRTAKELPFFAAGISMVIHPRNPMAPTTHLNYRYFELVNSD 130
Query: 556 GERVWWFGGGSDLTPNFLVEEDVIHFHSTLKQACDLHDPNFYPRYKEWCDRYFFYCSSK* 735
G+++WWFGGG+DLTP+ L EED HFH K+ACD HDP FYPR+K+W D YF K
Sbjct: 131 GKKIWWFGGGADLTPSILFEEDGKHFHKLHKEACDRHDPTFYPRFKKWADEYFLIKHRK- 189
Query: 736 KTRELGGIFFDD 771
+TR +GGIFFDD
Sbjct: 190 ETRGIGGIFFDD 201
>sp|Q9LR75|HEM6_ARATH Coproporphyrinogen III oxidase, chloroplast precursor
(Coproporphyrinogenase) (Coprogen oxidase) (LESION
INITIATION 2 protein)
Length = 386
Score = 214 bits (544), Expect = 3e-55
Identities = 106/213 (49%), Positives = 136/213 (63%), Gaps = 4/213 (1%)
Frame = +1
Query: 145 SEPVTEKSELLKSSSYRAKMEKLCLQVQGELCRSMERIDGKAKFLVDKWNRKAGGGGVTC 324
S+ VT S SSS RA+ E + Q +C ++E I+G KF D W+R GGGG++
Sbjct: 68 SDDVTPSSS---SSSVRARFETMIRAAQDSVCDAIEAIEGGPKFKEDVWSRPGGGGGISR 124
Query: 325 VISDGNVFEKAGVNISAIHGSLTKQAVIQMKARLTDLNEQLDYKFFACGISSVIHPSNPH 504
V+ DGNVFEKAGVN+S ++G + +A K +D + FFA G+SSV+HP NP
Sbjct: 125 VLQDGNVFEKAGVNVSVVYGVMPPEAYRAAKGSASD-QKPGPVPFFAAGVSSVLHPKNPF 183
Query: 505 VPACHFNFRYFELEKPH----GERVWWFGGGSDLTPNFLVEEDVIHFHSTLKQACDLHDP 672
P HFN+RYFE + P R WWFGGG+D TP ++ EEDV HFHS KQACD DP
Sbjct: 184 APTLHFNYRYFETDAPKDVPGAPRQWWFGGGTDFTPAYIFEEDVKHFHSIQKQACDKFDP 243
Query: 673 NFYPRYKEWCDRYFFYCSSK*KTRELGGIFFDD 771
+FYPR+K+WCD Y FY + + R LGGIFFDD
Sbjct: 244 SFYPRFKKWCDDY-FYIKHRDERRGLGGIFFDD 275
>sp|P35055|HEM6_SOYBN Coproporphyrinogen III oxidase, chloroplast precursor
(Coproporphyrinogenase) (Coprogen oxidase)
Length = 385
Score = 210 bits (535), Expect = 3e-54
Identities = 103/205 (50%), Positives = 132/205 (64%), Gaps = 4/205 (1%)
Frame = +1
Query: 169 ELLKSSSYRAKMEKLCLQVQGELCRSMERIDGKAKFLVDKWNRKAGGGGVTCVISDGNVF 348
E S+S RA+ EK+ + Q +C ++E DG A+F D W+R GGGG++ V+ DG V+
Sbjct: 72 EAQSSTSVRARFEKMIREAQDTVCSALEAADGGAQFKEDVWSRPGGGGGISRVLQDGAVW 131
Query: 349 EKAGVNISAIHGSLTKQAVIQMKARLTDLNEQLDYKFFACGISSVIHPSNPHVPACHFNF 528
EKAGVN+S ++G + A K TD + FFA GISSV+HP NP P HFN+
Sbjct: 132 EKAGVNVSVVYGVMPPDAYRAAKGVPTD-QKPGPVPFFAAGISSVLHPKNPFAPTLHFNY 190
Query: 529 RYFELEKPH----GERVWWFGGGSDLTPNFLVEEDVIHFHSTLKQACDLHDPNFYPRYKE 696
RYFE + P R WWFGGG+DLTP ++ EEDV HFHS KQACD +P FYPR+K+
Sbjct: 191 RYFETDAPKDAPGAPRQWWFGGGTDLTPAYIFEEDVKHFHSIQKQACDKFEPTFYPRFKK 250
Query: 697 WCDRYFFYCSSK*KTRELGGIFFDD 771
WCD Y FY + + R LGGIFFDD
Sbjct: 251 WCDDY-FYIKHRGERRGLGGIFFDD 274
>sp|Q42946|HEM6_TOBAC Coproporphyrinogen III oxidase, chloroplast precursor
(Coproporphyrinogenase) (Coprogen oxidase)
Length = 397
Score = 202 bits (514), Expect = 8e-52
Identities = 103/220 (46%), Positives = 134/220 (60%), Gaps = 6/220 (2%)
Frame = +1
Query: 130 PEIWMSEPVTEKSELLKSSSYRAKMEKLCLQVQGELCRSMERIDGKAKFLVDKWNRKAGG 309
P+ ++ E + SSS R + EK+ + Q +C ++E+ DG AKF D W+R GG
Sbjct: 70 PDAFLRESDMGSNVTSNSSSVRGRFEKMRREAQDSVCLAIEKADGGAKFKEDVWSRPGGG 129
Query: 310 GGVTCVISDGNVFEKAGVNISAIHGSLTKQAVIQMKARLTDLNEQLD--YKFFACGISSV 483
GG + V+ DG VFEKAGVN+S ++G + +A AR TD FFA G+SSV
Sbjct: 130 GGHSSVLQDGAVFEKAGVNVSVVYGVMPPEAY--RAARPTDNGNVKPGPIPFFAAGVSSV 187
Query: 484 IHPSNPHVPACHFNFRYFELEKPH----GERVWWFGGGSDLTPNFLVEEDVIHFHSTLKQ 651
+HP NP P HFN+RYFE + P R WWFGGG+D TP ++ EEDV HFHS K
Sbjct: 188 LHPKNPFAPTLHFNYRYFETDAPKDAPGAPRQWWFGGGTDFTPAYIFEEDVKHFHSVQKA 247
Query: 652 ACDLHDPNFYPRYKEWCDRYFFYCSSK*KTRELGGIFFDD 771
ACD D +FYPR+K+WC Y FY + + R LGGIFFDD
Sbjct: 248 ACDKFDASFYPRFKKWCVDY-FYIKHRDERRGLGGIFFDD 286
>sp|Q42840|HEM6_HORVU Coproporphyrinogen III oxidase, chloroplast precursor
(Coproporphyrinogenase) (Coprogen oxidase)
Length = 391
Score = 201 bits (511), Expect = 2e-51
Identities = 102/206 (49%), Positives = 130/206 (63%), Gaps = 9/206 (4%)
Frame = +1
Query: 181 SSSYRAKMEKLCLQVQGELCRSMERIDGKAK-FLVDKWNRKAGGGGVTCVISDGNVFEKA 357
S S R + E + +VQGE+C ++E DG K F+ D W+R G + V+ DGNVFEKA
Sbjct: 76 SGSVRERFEGMIRRVQGEICAALEEADGSGKRFVEDVWSRPGGVCVHSRVLQDGNVFEKA 135
Query: 358 GVNISAIHGSLTKQAVIQMKARL----TDLNEQLDYKFFACGISSVIHPSNPHVPACHFN 525
GVN+SA+ G + A K D ++ FF+ GISSV+HP NP P HFN
Sbjct: 136 GVNVSAVIGVCPRSAYRAAKGAAKNGAADGHKAGPVPFFSAGISSVLHPKNPFAPTLHFN 195
Query: 526 FRYFELEKPH----GERVWWFGGGSDLTPNFLVEEDVIHFHSTLKQACDLHDPNFYPRYK 693
+RYFE + P R WWFGGG+DLTP++L+EEDV HFHS KQ CD DP+FYPR+K
Sbjct: 196 YRYFETDAPKDVPGAPRSWWFGGGTDLTPSYLIEEDVKHFHSVQKQTCDKFDPSFYPRFK 255
Query: 694 EWCDRYFFYCSSK*KTRELGGIFFDD 771
+WCD Y FY + + R LGGIFFDD
Sbjct: 256 KWCDDY-FYIKHRNERRGLGGIFFDD 280
>sp|Q8YX58|HEM62_ANASP Coproporphyrinogen III oxidase, aerobic 2 (Coproporphyrinogenase 2)
(Coprogen oxidase 2)
Length = 347
Score = 190 bits (482), Expect = 4e-48
Identities = 87/192 (45%), Positives = 121/192 (63%)
Frame = +1
Query: 193 RAKMEKLCLQVQGELCRSMERIDGKAKFLVDKWNRKAGGGGVTCVISDGNVFEKAGVNIS 372
R + ++ +Q E+C ++E++DGKA F D W R GG G T VI +G VFE+ GVN S
Sbjct: 31 RQRSQQFMQNLQDEICTALEQLDGKASFHQDHWERAEGGEGRTRVIREGRVFEQGGVNFS 90
Query: 373 AIHGSLTKQAVIQMKARLTDLNEQLDYKFFACGISSVIHPSNPHVPACHFNFRYFELEKP 552
A+ G+ +++ + E ++FFA G S V+HP NP+VP H N+RYFE
Sbjct: 91 AVWGNSLPASILAQRP------EAAGHEFFATGTSMVLHPRNPYVPTVHLNYRYFEAGP- 143
Query: 553 HGERVWWFGGGSDLTPNFLVEEDVIHFHSTLKQACDLHDPNFYPRYKEWCDRYFFYCSSK 732
+WWFGGG+DLTP + +ED +HFH TLK ACD+H+P +YP +K WCD Y FY +
Sbjct: 144 ----IWWFGGGADLTPYYAFKEDAVHFHQTLKNACDVHNPEYYPTFKRWCDEY-FYLRHR 198
Query: 733 *KTRELGGIFFD 768
+ R +GGIFFD
Sbjct: 199 EEQRGIGGIFFD 210
>sp|P11353|HEM6_YEAST Coproporphyrinogen III oxidase (Coproporphyrinogenase) (Coprogen
oxidase) (COX)
Length = 328
Score = 189 bits (479), Expect = 9e-48
Identities = 100/205 (48%), Positives = 123/205 (60%), Gaps = 12/205 (5%)
Frame = +1
Query: 193 RAKMEKLCLQVQGELCRSMERIDGKAKFLVDKWNR-KAGGGGVTCVISDGNVFEKAGVNI 369
R +ME L + Q E+ + +E ID KF D W R GGGG + VI DG FEK GVN+
Sbjct: 13 RQQMEALIRRKQAEITQGLESID-TVKFHADTWTRGNDGGGGTSMVIQDGTTFEKGGVNV 71
Query: 370 SAIHGSLTKQAVIQMKARLTDLNEQLD----------YKFFACGISSVIHPSNPHVPACH 519
S ++G L+ AV MKA +L D KFFACG+S VIHP NPH P H
Sbjct: 72 SVVYGQLSPAAVSAMKADHKNLRLPEDPKTGLPVTDGVKFFACGLSMVIHPVNPHAPTTH 131
Query: 520 FNFRYFELEKPHGE-RVWWFGGGSDLTPNFLVEEDVIHFHSTLKQACDLHDPNFYPRYKE 696
N+RYFE G + WWFGGG+DLTP++L EED FH K A D HD YPR+K+
Sbjct: 132 LNYRYFETWNQDGTPQTWWFGGGADLTPSYLYEEDGQLFHQLHKDALDKHDTALYPRFKK 191
Query: 697 WCDRYFFYCSSK*KTRELGGIFFDD 771
WCD Y FY + + +TR +GGIFFDD
Sbjct: 192 WCDEY-FYITHRKETRGIGGIFFDD 215
Database: Non-redundant SwissProt sequences
Posted date: Dec 6, 2005 7:40 AM
Number of letters in database: 68,354,980
Number of sequences in database: 184,735
Database: swissprot.01
Posted date: Dec 6, 2005 8:18 AM
Number of letters in database: 66,202,850
Number of sequences in database: 184,431
Lambda K H
0.318 0.134 0.401
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 85,663,489
Number of Sequences: 369166
Number of extensions: 1688764
Number of successful extensions: 4460
Number of sequences better than 10.0: 10
Number of HSP's better than 10.0 without gapping: 4111
Number of HSP's successfully gapped in prelim test: 0
Number of HSP's that attempted gapping in prelim test: 0
Number of HSP's gapped (non-prelim): 4249
length of database: 68,354,980
effective HSP length: 108
effective length of database: 48,403,600
effective search space used: 7163732800
frameshift window, decay const: 40, 0.1
T: 12
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)