Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= Dr_sW_006_P20
(781 letters)
Database: Non-redundant SwissProt sequences
184,735 sequences; 68,354,980 total letters
Score E
Sequences producing significant alignments: (bits) Value
sp|Q15034|HERC3_HUMAN HECT domain and RCC1-like domain prot... 107 5e-23
sp|Q9UII4|HERC5_HUMAN HECT domain and RCC1-like domain prot... 54 5e-07
sp|Q05086|UBE3A_HUMAN Ubiquitin-protein ligase E3A (E6AP ub... 53 8e-07
sp|P40985|HUL4_YEAST Probable ubiquitin--protein ligase HUL4 50 9e-06
sp|O08759|UBE3A_MOUSE Ubiquitin-protein ligase E3A (Oncogen... 50 9e-06
sp|Q9UTG2|PUB2_SCHPO E3 ubiquitin--protein ligase pub2 40 0.007
sp|Q9HAU4|SMUF2_HUMAN Smad ubiquitination regulatory factor... 37 0.046
sp|Q8H0T4|UPL2_ARATH E3 ubiquitin protein ligase UPL2 (Ubiq... 37 0.079
sp|Q8GY23|UPL1_ARATH E3 ubiquitin protein ligase UPL1 (Ubiq... 37 0.079
sp|P46934|NEDD4_HUMAN E3 ubiquitin-protein ligase NEDD4 34 0.51
>sp|Q15034|HERC3_HUMAN HECT domain and RCC1-like domain protein 3
Length = 1050
Score = 107 bits (266), Expect = 5e-23
Identities = 59/165 (35%), Positives = 94/165 (56%), Gaps = 6/165 (3%)
Frame = +2
Query: 86 LTAALDLLKTIYMINERTKILSYSLFYIPTINEKIDIERNFIDW------ATANSHYLPV 247
+TAAL LL+ +Y +N + K + Y FYIP I+ +DI+ +++ W A +
Sbjct: 587 ITAALKLLEKLYKVNLKVKHVEYDTFYIPEISNLVDIQEDYLMWFLHQAGMKARPSIIQD 646
Query: 248 SFSFCSYPFVFDAKAKSKLLQVEAGLFMRNAVLETHTNLIMSILNAQESGVINMETPYFE 427
+ + CSYPF+FDA+AK+K+LQ +A L M+ AV + + +L + + +P+
Sbjct: 647 TVTLCSYPFIFDAQAKTKMLQTDAELQMQVAVNGANLQNVFMLLTLEP---LLARSPFLV 703
Query: 428 IGVNRATVLQDTLKVLEKASQKEFKKPLQISFSNEEAVDDGGVVK 562
+ V R ++ D L+ L S + KKPL++ F EEAVD GGV K
Sbjct: 704 LHVRRNNLVGDALRELSIHSDIDLKKPLKVIFDGEEAVDAGGVTK 748
Score = 55.8 bits (133), Expect = 1e-07
Identities = 25/63 (39%), Positives = 37/63 (58%)
Frame = +1
Query: 592 GLFKCNNQSKMCYFQQSVKNKDSIYRCVGQLCGLAIYNGIIIDLHFPLVLFKKLLGEVSS 771
G+F S + +F + + + + +G CGLAIYN ++DLHFPL L+KKLL
Sbjct: 764 GMFTYYQDSNLLWFSDTCFVEHNWFHLIGITCGLAIYNSTVVDLHFPLALYKKLLNVKPG 823
Query: 772 LDD 780
L+D
Sbjct: 824 LED 826
>sp|Q9UII4|HERC5_HUMAN HECT domain and RCC1-like domain protein 5 (Cyclin-E binding protein
1)
Length = 1024
Score = 53.9 bits (128), Expect = 5e-07
Identities = 42/162 (25%), Positives = 78/162 (48%), Gaps = 5/162 (3%)
Frame = +2
Query: 92 AALDLLKTIYMINERTKILSYSLFYIPTI----NEKIDIERNFIDWATAN-SHYLPVSFS 256
A L++LK ++ +N+ L S+F + + N +++ R ++ T + S +
Sbjct: 569 ALLEMLKKLHRVNQVKCQLPESIFQVDELLHRLNFFVEVCRRYLWKMTVDASENVQCCVI 628
Query: 257 FCSYPFVFDAKAKSKLLQVEAGLFMRNAVLETHTNLIMSILNAQESGVINMETPYFEIGV 436
F +PF+F+ +K KLL + L + + + H + S +E P F++ V
Sbjct: 629 FSHFPFIFNNLSKIKLLHTDTLLKIES---KKHKAYLRSAAIEEERESEFALRPTFDLTV 685
Query: 437 NRATVLQDTLKVLEKASQKEFKKPLQISFSNEEAVDDGGVVK 562
R +++D L L + ++ +K L +SFS E D GGV K
Sbjct: 686 RRNHLIEDVLNQLSQFENEDLRKELWVSFSGEIGYDLGGVKK 727
Score = 46.6 bits (109), Expect = 8e-05
Identities = 24/63 (38%), Positives = 36/63 (57%)
Frame = +1
Query: 592 GLFKCNNQSKMCYFQQSVKNKDSIYRCVGQLCGLAIYNGIIIDLHFPLVLFKKLLGEVSS 771
G+F + +F K + Y G LCGL+++N + +L FPL LFKKLL ++ S
Sbjct: 743 GMFMYPEGASCMWFPVKPKFEKKRYFFFGVLCGLSLFNCNVANLPFPLALFKKLLDQMPS 802
Query: 772 LDD 780
L+D
Sbjct: 803 LED 805
>sp|Q05086|UBE3A_HUMAN Ubiquitin-protein ligase E3A (E6AP ubiquitin-protein ligase)
(Oncogenic protein-associated protein E6-AP) (Human
papillomavirus E6-associated protein)
Length = 875
Score = 53.1 bits (126), Expect = 8e-07
Identities = 22/63 (34%), Positives = 40/63 (63%)
Frame = +1
Query: 592 GLFKCNNQSKMCYFQQSVKNKDSIYRCVGQLCGLAIYNGIIIDLHFPLVLFKKLLGEVSS 771
G+F + +K+ +F S + + +G + GLAIYN I+D+HFP+V+++KL+G+ +
Sbjct: 588 GMFTYDESTKLFWFNPSSFETEGQFTLIGIVLGLAIYNNCILDVHFPMVVYRKLMGKKGT 647
Query: 772 LDD 780
D
Sbjct: 648 FRD 650
Score = 50.4 bits (119), Expect = 5e-06
Identities = 36/149 (24%), Positives = 69/149 (46%), Gaps = 6/149 (4%)
Frame = +2
Query: 134 RTKILSYSLFYIPTINEKIDIERNFIDWATANSHYLPVSFSFCSYPFVFDAKAKSKLLQV 313
R ++ + F +NE +++++++ + + FSF + PF+ +A K+
Sbjct: 440 RKPLIPFEEFINEPLNEVLEMDKDYTFFKVETEN----KFSFMTCPFILNAVTKN----- 490
Query: 314 EAGLFMRNAVL---ETHTNLIMSILNAQESGVINMETPYFEIGVNRATVLQDTLKVLEKA 484
GL+ N + E ++ S++ Q+ PY + V R ++ D L LE
Sbjct: 491 -LGLYYDNRIRMYSERRITVLYSLVQGQQLN------PYLRLKVRRDHIIDDALVRLEMI 543
Query: 485 SQK---EFKKPLQISFSNEEAVDDGGVVK 562
+ + + KK L + F E+ VD+GGV K
Sbjct: 544 AMENPADLKKQLYVEFEGEQGVDEGGVSK 572
>sp|P40985|HUL4_YEAST Probable ubiquitin--protein ligase HUL4
Length = 892
Score = 49.7 bits (117), Expect = 9e-06
Identities = 32/104 (30%), Positives = 50/104 (48%)
Frame = +2
Query: 251 FSFCSYPFVFDAKAKSKLLQVEAGLFMRNAVLETHTNLIMSILNAQESGVINMETPYFEI 430
FSFC YPF+ K +++ E M + E ++S+ + V YF+I
Sbjct: 473 FSFCKYPFILSLGIKISIMEYEIRRIMEH---EAEQAFLISLDKGKSVDV------YFKI 523
Query: 431 GVNRATVLQDTLKVLEKASQKEFKKPLQISFSNEEAVDDGGVVK 562
V R + D+L+ + K Q + K L+I F NE +D GG+ K
Sbjct: 524 KVRRDVISHDSLRCI-KEHQGDLLKSLRIEFVNEPGIDAGGLRK 566
Score = 42.0 bits (97), Expect = 0.002
Identities = 26/72 (36%), Positives = 34/72 (47%), Gaps = 9/72 (12%)
Frame = +1
Query: 592 GLFKCNNQSKMCYFQQSVKNKDS---------IYRCVGQLCGLAIYNGIIIDLHFPLVLF 744
GLF +S +F N D +Y G + GLAI+N I+DL FP L+
Sbjct: 582 GLFIYIKESSRSWFAIDPPNFDKSKGKNSQLELYYLFGVVMGLAIFNSTILDLQFPKALY 641
Query: 745 KKLLGEVSSLDD 780
KKL E S +D
Sbjct: 642 KKLCSEPLSFED 653
>sp|O08759|UBE3A_MOUSE Ubiquitin-protein ligase E3A (Oncogenic protein-associated protein
E6-AP)
Length = 885
Score = 49.7 bits (117), Expect = 9e-06
Identities = 23/63 (36%), Positives = 40/63 (63%)
Frame = +1
Query: 592 GLFKCNNQSKMCYFQQSVKNKDSIYRCVGQLCGLAIYNGIIIDLHFPLVLFKKLLGEVSS 771
G+F + +K+ +F S + + +G L GLAIYN I+D+HFP+V+++KL+G+ +
Sbjct: 599 GMFTYDEATKLFWFNPSSFETEGQFTLIGIL-GLAIYNNCILDVHFPMVVYRKLMGKKGT 657
Query: 772 LDD 780
D
Sbjct: 658 FRD 660
Score = 45.8 bits (107), Expect = 1e-04
Identities = 40/183 (21%), Positives = 84/183 (45%), Gaps = 9/183 (4%)
Frame = +2
Query: 41 DLKQQNKMPDKSQIQLTAALDLLKT---IYMINERTKILSYSLFYIPTINEKIDIERNFI 211
+L Q + D+ + + +D L+T + ++ R ++S+ +N+ +++++++
Sbjct: 417 ELTLQELLGDERRNKKGPRVDPLETELGVKTLDCRKPLISFEESINEPLNDVLEMDKDYT 476
Query: 212 DWATANSHYLPVSFSFCSYPFVFDAKAKSKLLQVEAGLFMRNAVL---ETHTNLIMSILN 382
+ + SF + PF+ +A K+ GL+ N + E ++ S++
Sbjct: 477 FFKVETEN----KGSFMTCPFILNAVTKN------LGLYYDNRIRMYSERRITVLYSLVQ 526
Query: 383 AQESGVINMETPYFEIGVNRATVLQDTLKVLEKASQK---EFKKPLQISFSNEEAVDDGG 553
Q+ PY + V R ++ D L LE + + + KK L + F E+ VD+GG
Sbjct: 527 GQQLN------PYLTLKVRRDHIIDDALVRLEMIAMENPADLKKQLYVEFEGEQGVDEGG 580
Query: 554 VVK 562
V K
Sbjct: 581 VSK 583
>sp|Q9UTG2|PUB2_SCHPO E3 ubiquitin--protein ligase pub2
Length = 671
Score = 40.0 bits (92), Expect = 0.007
Identities = 18/44 (40%), Positives = 27/44 (61%)
Frame = +2
Query: 425 EIGVNRATVLQDTLKVLEKASQKEFKKPLQISFSNEEAVDDGGV 556
++ V+RAT +D ++ K S + KK L I F NE+ +D GGV
Sbjct: 318 QLKVSRATTFEDAYDIISKLSVSDMKKKLLIRFRNEDGLDYGGV 361
Score = 34.3 bits (77), Expect = 0.39
Identities = 16/41 (39%), Positives = 27/41 (65%)
Frame = +1
Query: 658 SIYRCVGQLCGLAIYNGIIIDLHFPLVLFKKLLGEVSSLDD 780
S +R VG++ GLAIY+ +D+ F L +K++L + L+D
Sbjct: 405 SYFRFVGRVMGLAIYHRRYLDVQFVLPFYKRILQKPLCLED 445
>sp|Q9HAU4|SMUF2_HUMAN Smad ubiquitination regulatory factor 2 (Ubiquitin--protein ligase
SMURF2) (Smad-specific E3 ubiquitin ligase 2) (hSMURF2)
Length = 748
Score = 37.4 bits (85), Expect = 0.046
Identities = 17/41 (41%), Positives = 28/41 (68%)
Frame = +1
Query: 658 SIYRCVGQLCGLAIYNGIIIDLHFPLVLFKKLLGEVSSLDD 780
S + VG++ G+A+++G ID F L +K+LLG+ +LDD
Sbjct: 481 SYFHFVGRIMGMAVFHGHYIDGGFTLPFYKQLLGKSITLDD 521
>sp|Q8H0T4|UPL2_ARATH E3 ubiquitin protein ligase UPL2 (Ubiquitin-protein ligase 2)
Length = 3658
Score = 36.6 bits (83), Expect = 0.079
Identities = 17/45 (37%), Positives = 25/45 (55%)
Frame = +2
Query: 428 IGVNRATVLQDTLKVLEKASQKEFKKPLQISFSNEEAVDDGGVVK 562
I V RA VL+D+ L S ++ K L + F EE +D GG+ +
Sbjct: 3298 ISVRRAYVLEDSYNQLRMRSPQDLKGRLNVQFQGEEGIDAGGLTR 3342
>sp|Q8GY23|UPL1_ARATH E3 ubiquitin protein ligase UPL1 (Ubiquitin-protein ligase 1)
Length = 3684
Score = 36.6 bits (83), Expect = 0.079
Identities = 17/45 (37%), Positives = 25/45 (55%)
Frame = +2
Query: 428 IGVNRATVLQDTLKVLEKASQKEFKKPLQISFSNEEAVDDGGVVK 562
I V RA VL+D+ L S ++ K L + F EE +D GG+ +
Sbjct: 3321 ISVRRAYVLEDSYNQLRMRSPQDLKGRLNVQFQGEEGIDAGGLTR 3365
>sp|P46934|NEDD4_HUMAN E3 ubiquitin-protein ligase NEDD4
Length = 1000
Score = 33.9 bits (76), Expect = 0.51
Identities = 18/48 (37%), Positives = 29/48 (60%), Gaps = 1/48 (2%)
Frame = +2
Query: 422 FEIGVNRATVLQDTLKVLEKASQKEF-KKPLQISFSNEEAVDDGGVVK 562
FE+ + RATVL+D+ + + + +F K L I F E+ +D GGV +
Sbjct: 643 FEMKLRRATVLEDSYRRIMGVKRADFLKARLWIEFDGEKGLDYGGVAR 690
Score = 29.6 bits (65), Expect = 9.7
Identities = 12/41 (29%), Positives = 26/41 (63%)
Frame = +1
Query: 658 SIYRCVGQLCGLAIYNGIIIDLHFPLVLFKKLLGEVSSLDD 780
S ++ +G++ G+A+Y+G ++D F +K +L + +L D
Sbjct: 733 SYFKFIGRVAGMAVYHGKLLDGFFIRPFYKMMLHKPITLHD 773
Database: Non-redundant SwissProt sequences
Posted date: Dec 6, 2005 7:40 AM
Number of letters in database: 68,354,980
Number of sequences in database: 184,735
Database: swissprot.01
Posted date: Dec 6, 2005 8:18 AM
Number of letters in database: 66,202,850
Number of sequences in database: 184,431
Lambda K H
0.318 0.134 0.401
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 83,226,732
Number of Sequences: 369166
Number of extensions: 1553119
Number of successful extensions: 4047
Number of sequences better than 10.0: 10
Number of HSP's better than 10.0 without gapping: 3907
Number of HSP's successfully gapped in prelim test: 0
Number of HSP's that attempted gapping in prelim test: 0
Number of HSP's gapped (non-prelim): 4041
length of database: 68,354,980
effective HSP length: 108
effective length of database: 48,403,600
effective search space used: 7308943600
frameshift window, decay const: 40, 0.1
T: 12
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)