Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= Dr_sW_006_P10
(924 letters)
Database: Non-redundant SwissProt sequences
184,735 sequences; 68,354,980 total letters
Score E
Sequences producing significant alignments: (bits) Value
sp|O75746|CMC1_HUMAN Calcium-binding mitochondrial carrier ... 49 2e-05
sp|Q8BH59|CMC1_MOUSE Calcium-binding mitochondrial carrier ... 47 6e-05
sp|Q9QXX4|CMC2_MOUSE Calcium-binding mitochondrial carrier ... 47 8e-05
sp|Q9UJS0|CMC2_HUMAN Calcium-binding mitochondrial carrier ... 46 2e-04
sp|Q8HXW2|CMC2_MACFA Calcium-binding mitochondrial carrier ... 46 2e-04
sp|Q9VA73|CMC1_DROME Calcium-binding mitochondrial carrier ... 44 6e-04
sp|Q21153|CMC1_CAEEL Probable calcium-binding mitochondrial... 43 0.001
sp|P36609|NCS2_CAEEL Neuronal calcium sensor 2 (NCS-2) 39 0.016
sp|P21457|RECO_BOVIN Recoverin (p26) 38 0.035
sp|P34057|RECO_MOUSE Recoverin (Cancer associated retinopat... 37 0.060
>sp|O75746|CMC1_HUMAN Calcium-binding mitochondrial carrier protein Aralar1
(Mitochondrial aspartate glutamate carrier 1) (Solute
carrier family 25 member 12)
Length = 678
Score = 48.9 bits (115), Expect = 2e-05
Identities = 57/245 (23%), Positives = 104/245 (42%), Gaps = 13/245 (5%)
Frame = +2
Query: 53 ENALINFSDYVFLLTVISTPQKQFEIAFRMFDLNGDGELDVEEFDVVRSIIRSGSPMGKR 232
++ LI++ +++ +V+ P F +AF++FD +G+GE+ F+ V+ I G +
Sbjct: 68 KDGLISYQEFLAFESVLCAPDSMFIVAFQLFDKSGNGEV---TFENVKEIF--GQTIIHH 122
Query: 233 HRDNIMTGNSISNGFNSSLSKYFFGKRGEKKLTINEFSIFQRRLQKEIMMLEFN-RYSPE 409
H I ++ + FG +K L EF+ F + LQ E F + +
Sbjct: 123 H---------IPFNWDCEFIRLHFGHNRKKHLNYTEFTQFLQELQLEHARQAFALKDKSK 173
Query: 410 NGIIKETDFADSLLMYADFHSTKKKKFLRRVRQKFNDENSIG---------ISFDDYFAF 562
+G+I DF+D ++ T F +EN + +SF + AF
Sbjct: 174 SGMISGLDFSDIMVTIRSHMLT-----------PFVEENLVSAAGGSISHQVSFSYFNAF 222
Query: 563 SQILKSISDIDTALTFYNLAGAPIDQATLKH--VSKAVANVDLNDHLIDIVFTLFD-ENN 733
+ +L ++ + + LAG D K A+ + IDI++ L D N
Sbjct: 223 NSLLNNMELV--RKIYSTLAGTRKDVEVTKEEFAQSAIRYGQVTPLEIDILYQLADLYNA 280
Query: 734 DGQLS 748
G+L+
Sbjct: 281 SGRLT 285
>sp|Q8BH59|CMC1_MOUSE Calcium-binding mitochondrial carrier protein Aralar1
(Mitochondrial aspartate glutamate carrier 1) (Solute
carrier family 25 member 12)
Length = 677
Score = 47.4 bits (111), Expect = 6e-05
Identities = 57/245 (23%), Positives = 104/245 (42%), Gaps = 13/245 (5%)
Frame = +2
Query: 53 ENALINFSDYVFLLTVISTPQKQFEIAFRMFDLNGDGELDVEEFDVVRSIIRSGSPMGKR 232
++ LI++ +++ +V+ P F +AF++FD +G+GE+ F+ V+ I G +
Sbjct: 68 KDGLISYQEFLAFESVLCAPDSMFIVAFQLFDKSGNGEV---TFENVKEIF--GQTIIHH 122
Query: 233 HRDNIMTGNSISNGFNSSLSKYFFGKRGEKKLTINEFSIFQRRLQKEIMMLEFN-RYSPE 409
H I ++ + FG +K L EF+ F + LQ E F + +
Sbjct: 123 H---------IPFNWDCEFIRLHFGHNRKKHLNYVEFTQFLQELQLEHARQAFALKDKSK 173
Query: 410 NGIIKETDFADSLLMYADFHSTKKKKFLRRVRQKFNDENSIG---------ISFDDYFAF 562
+G+I DF+D ++ T F +EN + +SF + AF
Sbjct: 174 SGMISGLDFSDVMVTIRSHMLT-----------PFVEENLVSAAGGGTSHQVSFSYFNAF 222
Query: 563 SQILKSISDIDTALTFYNLAGAPIDQATLKH--VSKAVANVDLNDHLIDIVFTLFD-ENN 733
+ +L ++ + + LAG D K A+ + IDI++ L D N
Sbjct: 223 NSLLNNMELV--RKIYSTLAGTRKDIEVTKEEFAQSAIRYGQVTPLEIDILYQLADLYNA 280
Query: 734 DGQLS 748
G+L+
Sbjct: 281 SGRLT 285
>sp|Q9QXX4|CMC2_MOUSE Calcium-binding mitochondrial carrier protein Aralar2
(Mitochondrial aspartate glutamate carrier 2) (Solute
carrier family 25 member 13) (Citrin)
Length = 676
Score = 47.0 bits (110), Expect = 8e-05
Identities = 37/134 (27%), Positives = 63/134 (47%), Gaps = 1/134 (0%)
Frame = +2
Query: 53 ENALINFSDYVFLLTVISTPQKQFEIAFRMFDLNGDGELDVEEFDVVRSIIRSGSPMGKR 232
++ LI+F ++V +V+ P F +AF++FD G GE+ E+ V+ I G +
Sbjct: 69 KDGLISFQEFVAFESVLCAPDALFMVAFQLFDKAGKGEVTFED---VKQIF--GQTTIHQ 123
Query: 233 HRDNIMTGNSISNGFNSSLSKYFFGKRGEKKLTINEFSIFQRRLQKEIMMLEF-NRYSPE 409
H I ++S + FGK ++ LT EF+ F +Q E F R + +
Sbjct: 124 H---------IPFNWDSEFVQLHFGKERKRHLTYAEFTQFLLEIQLEHAKQAFVQRDNAK 174
Query: 410 NGIIKETDFADSLL 451
G + DF D ++
Sbjct: 175 TGKVSAIDFRDIMV 188
>sp|Q9UJS0|CMC2_HUMAN Calcium-binding mitochondrial carrier protein Aralar2
(Mitochondrial aspartate glutamate carrier 2) (Solute
carrier family 25 member 13) (Citrin)
Length = 675
Score = 45.8 bits (107), Expect = 2e-04
Identities = 36/134 (26%), Positives = 60/134 (44%), Gaps = 1/134 (0%)
Frame = +2
Query: 53 ENALINFSDYVFLLTVISTPQKQFEIAFRMFDLNGDGELDVEEFDVVRSIIRSGSPMGKR 232
++ LI+F ++V +V+ P F +AF++FD G GE+ E+ V G +
Sbjct: 69 KDGLISFQEFVAFESVLCAPDALFMVAFQLFDKAGKGEVTFEDVKQV-----FGQTTIHQ 123
Query: 233 HRDNIMTGNSISNGFNSSLSKYFFGKRGEKKLTINEFSIFQRRLQKEIMMLEF-NRYSPE 409
H I ++S + FGK ++ LT EF+ F +Q E F R +
Sbjct: 124 H---------IPFNWDSEFVQLHFGKERKRHLTYAEFTQFLLEIQLEHAKQAFVQRDNAR 174
Query: 410 NGIIKETDFADSLL 451
G + DF D ++
Sbjct: 175 TGRVTAIDFRDIMV 188
>sp|Q8HXW2|CMC2_MACFA Calcium-binding mitochondrial carrier protein Aralar2
(Mitochondrial aspartate glutamate carrier 2) (Solute
carrier family 25 member 13) (Citrin)
Length = 674
Score = 45.8 bits (107), Expect = 2e-04
Identities = 36/134 (26%), Positives = 60/134 (44%), Gaps = 1/134 (0%)
Frame = +2
Query: 53 ENALINFSDYVFLLTVISTPQKQFEIAFRMFDLNGDGELDVEEFDVVRSIIRSGSPMGKR 232
++ LI+F ++V +V+ P F +AF++FD G GE+ E+ V G +
Sbjct: 69 KDGLISFQEFVAFESVLCAPDALFMVAFQLFDKAGKGEVTFEDVKQV-----FGQTTIHQ 123
Query: 233 HRDNIMTGNSISNGFNSSLSKYFFGKRGEKKLTINEFSIFQRRLQKEIMMLEF-NRYSPE 409
H I ++S + FGK ++ LT EF+ F +Q E F R +
Sbjct: 124 H---------IPFNWDSEFVQLHFGKERKRHLTYAEFTQFLLEIQLEHAKQAFVQRDNAS 174
Query: 410 NGIIKETDFADSLL 451
G + DF D ++
Sbjct: 175 TGRVTAIDFRDIMV 188
>sp|Q9VA73|CMC1_DROME Calcium-binding mitochondrial carrier Aralar1
Length = 695
Score = 43.9 bits (102), Expect = 6e-04
Identities = 58/278 (20%), Positives = 115/278 (41%), Gaps = 16/278 (5%)
Frame = +2
Query: 53 ENALINFSDYVFLLTVISTPQKQFEIAFRMFDLNGDGELDVEEF-DVVRSIIRSGSPMGK 229
++ LI+FS++ ++ TP + AF++FD G+G + +F DVV+ +
Sbjct: 87 KDGLISFSEFQAFEGLLCTPDALYRTAFQLFDRKGNGTVSYADFADVVQKT--------E 138
Query: 230 RHRDNIMTGNSISNGFNSSLSKYFFGKRGEKKLTINEFSIFQRRLQKEIMMLEFNRYSPE 409
H + I + K +FG + ++ + EF+ +E M F P
Sbjct: 139 LH-------SKIPFSLDGPFIKRYFGDKKQRLINYAEFTQLLHDFHEEHAMEAFRSKDPA 191
Query: 410 -NGIIKETDFADSLLMYADFHSTKKKKFLRRVRQKF-NDENSIGISFDDYFAFSQILKSI 583
G I DF D ++ + K+ VR + +SF + AF+ +L ++
Sbjct: 192 GTGFISPLDFQDIIV------NVKRHLLTPGVRDNLVSVTEGHKVSFPYFIAFTSLLNNM 245
Query: 584 SDIDTALTFYNLAGAPIDQATLKHVSKAVANVDLNDHL-IDIVFTL---------FDENN 733
++ + + G+ D T + A + L IDI+F L D ++
Sbjct: 246 -ELIKQVYLHATEGSRTDMITKDQILLAAQTMSQITPLEIDILFHLAGAVHQAGRIDYSD 304
Query: 734 DGQLSNKEFIMVMKQRL--FRGLDRPMD-TGFIRLMSA 838
++ + + M RL + ++ P D + FI+++ +
Sbjct: 305 LSNIAPEHYTKHMTHRLAEIKAVESPADRSAFIQVLES 342
>sp|Q21153|CMC1_CAEEL Probable calcium-binding mitochondrial carrier K02F3.2
Length = 702
Score = 42.7 bits (99), Expect = 0.001
Identities = 56/254 (22%), Positives = 100/254 (39%), Gaps = 12/254 (4%)
Frame = +2
Query: 65 INFSDYVFLLTVISTPQKQFEIAFRMFDLNGDGELDVEEFDVVRSIIRSGSPMGKRHRDN 244
I+F ++ ++ +P + AF +FD N + +EF+ ++IR P+ + D
Sbjct: 113 ISFEEFCAFEALLCSPDALYLTAFELFDRNASDTISCDEFE---AVIRHTQPLHDQDFD- 168
Query: 245 IMTGNSISNGFNSSLSKYFFGKRGEKKLTINEFSIFQRRLQKEIMMLEFNRYSPE-NGII 421
F+S K +FG ++ + + F +E + F RY NG I
Sbjct: 169 ----------FSSEFIKRYFGADKQRNVNYHSFCQLLHDFYEEQGIQAFKRYDKNGNGTI 218
Query: 422 KETDFADSLLMYADFHSTKKKKFLRRVRQKFNDENSIGIS---------FDDYFAFSQIL 574
DF + +T K L F N I +S F Y AF+ +L
Sbjct: 219 SSLDFQQIM-------TTVKGHLL----TDFVRHNLIAVSGGASGHKVTFPYYAAFNSLL 267
Query: 575 KSISDIDTALTFYNLAGAPIDQATLKHVSKAVANVDLNDHLIDIVFTLFDENNDGQ--LS 748
+ I Y I ++ + S+ + N + ++I+F L + N+ G+ L
Sbjct: 268 AKMELIKRV---YVSTTRKIGKSKIFRFSETIKK--YNKNKVEILFHLSELNHPGRKTLC 322
Query: 749 NKEFIMVMKQRLFR 790
K+ + +RL R
Sbjct: 323 LKDIQAIDPERLKR 336
>sp|P36609|NCS2_CAEEL Neuronal calcium sensor 2 (NCS-2)
Length = 190
Score = 39.3 bits (90), Expect = 0.016
Identities = 28/116 (24%), Positives = 57/116 (49%), Gaps = 11/116 (9%)
Frame = +2
Query: 56 NALINFSDYVFLLTVIS--TPQKQFEIAFRMFDLNGDGELDVEE-FDVVRSIIRSGSPMG 226
+ I+F +++ + V S TP+++ E AFRM+D++G+G +D +E ++ +I P
Sbjct: 79 SGFIDFKEFLLAINVTSSGTPEQKLEWAFRMYDIDGNGTIDEKEMIKIIEAIYEMLGPEV 138
Query: 227 KRHRDN--------IMTGNSISNGFNSSLSKYFFGKRGEKKLTINEFSIFQRRLQK 370
+ D+ I ++N +L ++ G +K+L F I ++K
Sbjct: 139 TKSADDSPRKRAKMIFEKMDVNNDKELTLKEFVDGCLADKEL----FQILTNEVKK 190
Score = 30.0 bits (66), Expect = 9.6
Identities = 28/119 (23%), Positives = 52/119 (43%), Gaps = 15/119 (12%)
Frame = +2
Query: 452 MYADFH-STKKKKFLRRVRQKFNDENSIGISFDDYFAFSQILKSISD---IDTALTFYNL 619
+Y DF S + F V + F+ +NS I F ++ + S + ++ A Y++
Sbjct: 53 VYKDFFPSGSAEGFCEHVFRTFDTDNSGFIDFKEFLLAINVTSSGTPEQKLEWAFRMYDI 112
Query: 620 AG-APIDQATLKHVSKAVANV----------DLNDHLIDIVFTLFDENNDGQLSNKEFI 763
G ID+ + + +A+ + D ++F D NND +L+ KEF+
Sbjct: 113 DGNGTIDEKEMIKIIEAIYEMLGPEVTKSADDSPRKRAKMIFEKMDVNNDKELTLKEFV 171
>sp|P21457|RECO_BOVIN Recoverin (p26)
Length = 202
Score = 38.1 bits (87), Expect = 0.035
Identities = 31/110 (28%), Positives = 56/110 (50%), Gaps = 3/110 (2%)
Frame = +2
Query: 65 INFSDYVFLLTVISTPQ--KQFEIAFRMFDLNGDGELDVEE-FDVVRSIIRSGSPMGKRH 235
++F +YV L + S + ++ E AF ++D++G+G + E ++V +I + SP +H
Sbjct: 81 LDFKEYVIALHMTSAGKTNQKLEWAFSLYDVDGNGTISKNEVLEIVTAIFKMISPEDTKH 140
Query: 236 RDNIMTGNSISNGFNSSLSKYFFGKRGEKKLTINEFSIFQRRLQKEIMML 385
+ + + + FFGK+ + KLT EF I KEI+ L
Sbjct: 141 ----LPEDENTPEKRAEKIWGFFGKKDDDKLTEKEF-IEGTLANKEILRL 185
>sp|P34057|RECO_MOUSE Recoverin (Cancer associated retinopathy protein) (CAR protein) (23
kDa photoreceptor cell-specific protein)
Length = 202
Score = 37.4 bits (85), Expect = 0.060
Identities = 31/109 (28%), Positives = 52/109 (47%), Gaps = 2/109 (1%)
Frame = +2
Query: 65 INFSDYVFLL--TVISTPQKQFEIAFRMFDLNGDGELDVEEFDVVRSIIRSGSPMGKRHR 238
++F +YV L T P ++ E AF ++D++G+G + E V I+ + M K
Sbjct: 81 LDFKEYVIALHMTTAGKPTQKLEWAFSLYDVDGNGTISKNE---VLEIVMAIFKMIKPED 137
Query: 239 DNIMTGNSISNGFNSSLSKYFFGKRGEKKLTINEFSIFQRRLQKEIMML 385
++ + + + FFGK+ + KLT EF I KEI+ L
Sbjct: 138 VKLLPDDENTPEKRAEKIWAFFGKKEDDKLTEEEF-IEGTLANKEILRL 185
Score = 33.1 bits (74), Expect = 1.1
Identities = 15/42 (35%), Positives = 22/42 (52%)
Frame = +2
Query: 104 STPQKQFEIAFRMFDLNGDGELDVEEFDVVRSIIRSGSPMGK 229
S P+ + FR FD N DG LD +E+ + + +G P K
Sbjct: 60 SDPKAYAQHVFRSFDANSDGTLDFKEYVIALHMTTAGKPTQK 101
Database: Non-redundant SwissProt sequences
Posted date: Dec 6, 2005 7:40 AM
Number of letters in database: 68,354,980
Number of sequences in database: 184,735
Database: swissprot.01
Posted date: Dec 6, 2005 8:18 AM
Number of letters in database: 66,202,850
Number of sequences in database: 184,431
Lambda K H
0.318 0.134 0.401
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 101,124,479
Number of Sequences: 369166
Number of extensions: 2014132
Number of successful extensions: 6346
Number of sequences better than 10.0: 10
Number of HSP's better than 10.0 without gapping: 5418
Number of HSP's successfully gapped in prelim test: 0
Number of HSP's that attempted gapping in prelim test: 0
Number of HSP's gapped (non-prelim): 6312
length of database: 68,354,980
effective HSP length: 110
effective length of database: 48,034,130
effective search space used: 9462723610
frameshift window, decay const: 40, 0.1
T: 12
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)