Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= Dr_sW_006_P06
(655 letters)
Database: Non-redundant SwissProt sequences
184,735 sequences; 68,354,980 total letters
Score E
Sequences producing significant alignments: (bits) Value
sp|P23785|GRN_RAT Granulins precursor [Contains: Acrogranin... 104 2e-22
sp|P28797|GRN_CAVPO Granulins precursor (Proepithelin) (PEP... 103 5e-22
sp|P28798|GRN_MOUSE Granulins precursor (Acrogranin) (Proep... 102 1e-21
sp|P28799|GRN_HUMAN Granulins precursor (Proepithelin) (PEP... 102 1e-21
sp|P80059|PMD1_LOCMI Pars intercerebralis major peptide D1 ... 63 8e-10
sp|P80930|ENA1_HORSE Antimicrobial peptide eNAP-1 57 4e-08
sp|P81013|GRN1_CYPCA Granulin-1 52 1e-06
sp|P81014|GRN2_CYPCA Granulin-2 49 9e-06
sp|P81015|GRN3_CYPCA Granulin-3 45 2e-04
sp|P43297|RD21A_ARATH Cysteine proteinase RD21a precursor (... 43 8e-04
>sp|P23785|GRN_RAT Granulins precursor [Contains: Acrogranin; Granulin-1 (Granulin G);
Granulin-2 (Granulin F); Granulin-3 (Granulin B)
(Epithelin-2); Granulin-4 (Granulin A) (Epithelin-1);
Granulin-5 (Granulin C); Granulin-6 (Granulin D);
Granulin-7 (Granulin E)]
Length = 588
Score = 104 bits (259), Expect = 2e-22
Identities = 47/141 (33%), Positives = 63/141 (44%)
Frame = +3
Query: 123 NGKALCGDQKTCCVSKSGGHQCCQYPNAVCCGDQMHCCPEGTTCDLVNKRCIHQSNEPIE 302
+ K C D TCC +G + CC PNA+CC D +HCCP+ T CDL+ +CI +
Sbjct: 208 DAKTQCPDDSTCCELPTGKYGCCPMPNAICCSDHLHCCPQDTVCDLIQSKCISKD----- 262
Query: 303 WPVVKIVDPAKIEIPKYTVERNPLREFIIKVWNKSTCPDGSLCPNSFPCCLFAPGQYFCC 482
++P Y V N+ C CP+ + CC G + CC
Sbjct: 263 -----YTTDLMTKLPGYPV-------------NEVKCDLEVSCPDGYTCCRLNTGAWGCC 304
Query: 483 PFPGGVCCSSPPGCVPSGQQC 545
PF VCC C P+G QC
Sbjct: 305 PFTKAVCCEDHIHCCPAGFQC 325
Score = 100 bits (250), Expect = 3e-21
Identities = 49/137 (35%), Positives = 63/137 (45%), Gaps = 1/137 (0%)
Frame = +3
Query: 138 CGDQKTCCVSKSGGHQCCQYPNAVCCGDQMHCCPEGTTCDLVNKRCIHQSNEPIEWPVVK 317
C D TCC+ G CC P A CC D++HCCP G +CDLV+ RCI + P++K
Sbjct: 132 CPDSATCCIMIDGSWGCCPMPQASCCEDRVHCCPHGASCDLVHTRCISPTG---THPLLK 188
Query: 318 IVDPAKIEIPKYTVERNPLREFIIKVWNKSTCPDG-SLCPNSFPCCLFAPGQYFCCPFPG 494
K+ +R V CPD + CP+ CC G+Y CCP P
Sbjct: 189 ----------KFPAQRTNRAVASFSV----VCPDAKTQCPDDSTCCELPTGKYGCCPMPN 234
Query: 495 GVCCSSPPGCVPSGQQC 545
+CCS C P C
Sbjct: 235 AICCSDHLHCCPQDTVC 251
Score = 90.5 bits (223), Expect = 3e-18
Identities = 46/141 (32%), Positives = 63/141 (44%)
Frame = +3
Query: 138 CGDQKTCCVSKSGGHQCCQYPNAVCCGDQMHCCPEGTTCDLVNKRCIHQSNEPIEWPVVK 317
C D TCC +G CC + AVCC D +HCCP G C C ++ P +K
Sbjct: 287 CPDGYTCCRLNTGAWGCCPFTKAVCCEDHIHCCPAGFQCHTETGTC---ELGVLQVPWMK 343
Query: 318 IVDPAKIEIPKYTVERNPLREFIIKVWNKSTCPDGSLCPNSFPCCLFAPGQYFCCPFPGG 497
V A + +P + +N + C D S CP++ CC + G + CCP P
Sbjct: 344 KV-TASLSLPDPQILKNDV-----------PCDDFSSCPSNNTCCRLSSGDWGCCPMPEA 391
Query: 498 VCCSSPPGCVPSGQQCLSG*Y 560
VCC C P G +C+ Y
Sbjct: 392 VCCLDHQHCCPQGFKCMDEGY 412
Score = 85.9 bits (211), Expect = 8e-17
Identities = 46/136 (33%), Positives = 60/136 (44%)
Frame = +3
Query: 138 CGDQKTCCVSKSGGHQCCQYPNAVCCGDQMHCCPEGTTCDLVNKRCIHQSNEPIEWPVVK 317
C +TCC S G CCQ P+AVCC D+ HCCP G TC++ + C
Sbjct: 447 CPVGQTCCPSLKGSWACCQLPHAVCCEDRQHCCPAGYTCNVKARTC-------------- 492
Query: 318 IVDPAKIEIPKYTVERNPLREFIIKVWNKSTCPDGSLCPNSFPCCLFAPGQYFCCPFPGG 497
E +V+ + F KV N C G C ++ CC + G + CCP+ G
Sbjct: 493 -------EKDAGSVQPSMDLTFGSKVGNVE-CGAGHFCHDNQSCCKDSQGGWACCPYVKG 544
Query: 498 VCCSSPPGCVPSGQQC 545
VCC C P G C
Sbjct: 545 VCCRDGRHCCPIGFHC 560
Score = 79.0 bits (193), Expect = 1e-14
Identities = 39/136 (28%), Positives = 54/136 (39%)
Frame = +3
Query: 138 CGDQKTCCVSKSGGHQCCQYPNAVCCGDQMHCCPEGTTCDLVNKRCIHQSNEPIEWPVVK 317
C TCC SG CC P AVCC D HCCP+G C +++ + + +
Sbjct: 369 CPSNNTCCRLSSGDWGCCPMPEAVCCLDHQHCCPQGFKC--MDEGYCQKGDRMVAG---- 422
Query: 318 IVDPAKIEIPKYTVERNPLREFIIKVWNKSTCPDGSLCPNSFPCCLFAPGQYFCCPFPGG 497
+E+ P+R+ + C + CP CC G + CC P
Sbjct: 423 -------------LEKMPVRQTTLLQHGDIGCDQHTSCPVGQTCCPSLKGSWACCQLPHA 469
Query: 498 VCCSSPPGCVPSGQQC 545
VCC C P+G C
Sbjct: 470 VCCEDRQHCCPAGYTC 485
Score = 72.0 bits (175), Expect = 1e-12
Identities = 37/136 (27%), Positives = 48/136 (35%)
Frame = +3
Query: 138 CGDQKTCCVSKSGGHQCCQYPNAVCCGDQMHCCPEGTTCDLVNKRCIHQSNEPIEWPVVK 317
C D +C ++ SG CC + V C D HCCP G C K C S+ +
Sbjct: 67 CPDGYSCLLTVSGTSSCCPFSEGVSCDDGQHCCPRGFHCSADGKSCSQISDSLL------ 120
Query: 318 IVDPAKIEIPKYTVERNPLREFIIKVWNKSTCPDGSLCPNSFPCCLFAPGQYFCCPFPGG 497
++ P E CP+S CC+ G + CCP P
Sbjct: 121 ----GAVQCPGSQFE----------------------CPDSATCCIMIDGSWGCCPMPQA 154
Query: 498 VCCSSPPGCVPSGQQC 545
CC C P G C
Sbjct: 155 SCCEDRVHCCPHGASC 170
Score = 58.5 bits (140), Expect = 1e-08
Identities = 24/65 (36%), Positives = 32/65 (49%)
Frame = +3
Query: 138 CGDQKTCCVSKSGGHQCCQYPNAVCCGDQMHCCPEGTTCDLVNKRCIHQSNEPIEWPVVK 317
C D ++CC GG CC Y VCC D HCCP G C +C+ + W ++
Sbjct: 522 CHDNQSCCKDSQGGWACCPYVKGVCCRDGRHCCPIGFHCSAKGTKCLRKKTP--RWDIL- 578
Query: 318 IVDPA 332
+ DPA
Sbjct: 579 LRDPA 583
Score = 42.0 bits (97), Expect = 0.001
Identities = 17/46 (36%), Positives = 20/46 (43%)
Frame = +3
Query: 408 TCPDGSLCPNSFPCCLFAPGQYFCCPFPGGVCCSSPPGCVPSGQQC 545
+C CP+ + C L G CCPF GV C C P G C
Sbjct: 60 SCQIRDHCPDGYSCLLTVSGTSSCCPFSEGVSCDDGQHCCPRGFHC 105
>sp|P28797|GRN_CAVPO Granulins precursor (Proepithelin) (PEPI) [Contains: Acrogranin;
Granulin-1; Granulin-2; Granulin-3; Granulin-4;
Granulin-5; Granulin-6; Granulin-7]
Length = 591
Score = 103 bits (256), Expect = 5e-22
Identities = 47/141 (33%), Positives = 64/141 (45%)
Frame = +3
Query: 123 NGKALCGDQKTCCVSKSGGHQCCQYPNAVCCGDQMHCCPEGTTCDLVNKRCIHQSNEPIE 302
+ ++ C D TCC+ SG + CC PNA+CC D +HCCP+ T CDL RC+ Q+
Sbjct: 210 DSRSQCPDDTTCCLLASGEYGCCPMPNAICCSDHLHCCPQDTVCDLRQSRCLSQNK---- 265
Query: 303 WPVVKIVDPAKIEIPKYTVERNPLREFIIKVWNKSTCPDGSLCPNSFPCCLFAPGQYFCC 482
++P +T VW+ C CP CC G++ CC
Sbjct: 266 ------AKTLLTKLPSWT------------VWDVE-CDQEVSCPEGQTCCRLQSGKWGCC 306
Query: 483 PFPGGVCCSSPPGCVPSGQQC 545
PFP VCC C P +C
Sbjct: 307 PFPKAVCCEDHVHCCPERFRC 327
Score = 100 bits (249), Expect = 3e-21
Identities = 54/146 (36%), Positives = 69/146 (47%), Gaps = 6/146 (4%)
Frame = +3
Query: 126 GKALCGDQKTCCVSKSGGHQCCQYPNAVCCGDQMHCCPEGTTCDLVNKRCIHQ-SNEPIE 302
G+ C D TCC G CC P A CC D++HCCP G +CDLV+ RC+ + P+
Sbjct: 115 GEFECPDSSTCCHMLDGSWGCCPMPQASCCEDRVHCCPHGASCDLVHIRCVTALGSHPLT 174
Query: 303 WPVVKIVDPAKIEIPKYT-VERNPLRE---FIIKVWNKSTCPDG-SLCPNSFPCCLFAPG 467
+ PA + YT E P+ + CPD S CP+ CCL A G
Sbjct: 175 TKL-----PA--QRTNYTGAEGTPVVSPGLLPAALPTSVICPDSRSQCPDDTTCCLLASG 227
Query: 468 QYFCCPFPGGVCCSSPPGCVPSGQQC 545
+Y CCP P +CCS C P C
Sbjct: 228 EYGCCPMPNAICCSDHLHCCPQDTVC 253
Score = 91.7 bits (226), Expect = 2e-18
Identities = 47/140 (33%), Positives = 60/140 (42%)
Frame = +3
Query: 132 ALCGDQKTCCVSKSGGHQCCQYPNAVCCGDQMHCCPEGTTCDLVNKRCIHQSNEPIEWPV 311
A C ++TCC GG CCQ P+AVCC D HCCP G TC++ + C
Sbjct: 445 ASCPVRQTCCPKLGGGWACCQLPHAVCCEDGQHCCPAGYTCNVKARSC------------ 492
Query: 312 VKIVDPAKIEIPKYTVERNPLREFIIKVWNKSTCPDGSLCPNSFPCCLFAPGQYFCCPFP 491
K D A + P + + C D C + CC + G + CCPF
Sbjct: 493 EKAADGAHLAAPLAVGSTGGVMDV--------ACGDRHFCHDEQTCCRDSRGGWACCPFH 544
Query: 492 GGVCCSSPPGCVPSGQQCLS 551
GVCC C P+G C S
Sbjct: 545 QGVCCKDQRHCCPAGFHCES 564
Score = 71.6 bits (174), Expect = 2e-12
Identities = 41/135 (30%), Positives = 54/135 (40%), Gaps = 6/135 (4%)
Frame = +3
Query: 138 CGDQKTCCVSKSGGHQCCQYPNAVCCGDQMHCCPEGTTCDLVNKRCIHQSNEPIEWPVVK 317
C + +TCC +SG CC +P AVCC D +HCCPE C C Q + W
Sbjct: 289 CPEGQTCCRLQSGKWGCCPFPKAVCCEDHVHCCPERFRCHTEKDTC-EQGLLQVPWAQKT 347
Query: 318 IVDPAKIEIPK------YTVERNPLREFIIKVWNKSTCPDGSLCPNSFPCCLFAPGQYFC 479
P++ P PLR I +C + C CC A G++ C
Sbjct: 348 PAQPSRPSQPSPPGPPGPPSPPGPLRSEI-------SCDEVVSCRPGNICCRLASGEWGC 400
Query: 480 CPFPGGVCCSSPPGC 524
CP G C + C
Sbjct: 401 CPSSEGYLCMAGERC 415
Score = 70.9 bits (172), Expect = 3e-12
Identities = 38/139 (27%), Positives = 49/139 (35%), Gaps = 1/139 (0%)
Frame = +3
Query: 132 ALCGDQKTCCVSKSGGHQCCQYPNAVCCGDQMHCCPEGTTCDLVNKRCIHQSNEPIEWPV 311
A C +C ++ +G CC + A+ CGD HCCP G C CI + +
Sbjct: 51 ANCPIGHSCVLTAAGTAACCPFSQAMACGDGHHCCPYGFHCSTDGGTCIQRPD------- 103
Query: 312 VKIVDPAKIEIPKYTVERNPLREFIIKVWNKSTCPDGSL-CPNSFPCCLFAPGQYFCCPF 488
I + CP G CP+S CC G + CCP
Sbjct: 104 -------------------------IHLLGAVQCPGGEFECPDSSTCCHMLDGSWGCCPM 138
Query: 489 PGGVCCSSPPGCVPSGQQC 545
P CC C P G C
Sbjct: 139 PQASCCEDRVHCCPHGASC 157
Score = 65.9 bits (159), Expect = 9e-11
Identities = 23/51 (45%), Positives = 30/51 (58%)
Frame = +3
Query: 138 CGDQKTCCVSKSGGHQCCQYPNAVCCGDQMHCCPEGTTCDLVNKRCIHQSN 290
C D++TCC GG CC + VCC DQ HCCP G C+ RC+H+ +
Sbjct: 524 CHDEQTCCRDSRGGWACCPFHQGVCCKDQRHCCPAGFHCESQGTRCVHKKS 574
Score = 40.8 bits (94), Expect = 0.003
Identities = 16/45 (35%), Positives = 19/45 (42%)
Frame = +3
Query: 411 CPDGSLCPNSFPCCLFAPGQYFCCPFPGGVCCSSPPGCVPSGQQC 545
C + CP CC G + CC P VCC C P+G C
Sbjct: 441 CDQHASCPVRQTCCPKLGGGWACCQLPHAVCCEDGQHCCPAGYTC 485
Score = 37.7 bits (86), Expect = 0.026
Identities = 16/45 (35%), Positives = 18/45 (40%)
Frame = +3
Query: 411 CPDGSLCPNSFPCCLFAPGQYFCCPFPGGVCCSSPPGCVPSGQQC 545
C + CP C L A G CCPF + C C P G C
Sbjct: 47 CQSPANCPIGHSCVLTAAGTAACCPFSQAMACGDGHHCCPYGFHC 91
>sp|P28798|GRN_MOUSE Granulins precursor (Acrogranin) (Proepithelin) (PEPI) (PC
cell-derived growth factor) (PCDGF) [Contains: Granulin
1; Granulin 2; Granulin 3; Granulin 4; Granulin 5;
Granulin 6; Granulin 7]
Length = 589
Score = 102 bits (253), Expect = 1e-21
Identities = 46/141 (32%), Positives = 67/141 (47%)
Frame = +3
Query: 123 NGKALCGDQKTCCVSKSGGHQCCQYPNAVCCGDQMHCCPEGTTCDLVNKRCIHQSNEPIE 302
+ K C D TCC +G + CC PNA+CC D +HCCP+ T CDL+ +C+ ++
Sbjct: 209 DAKTQCPDDSTCCELPTGKYGCCPMPNAICCSDHLHCCPQDTVCDLIQSKCLSKN----- 263
Query: 303 WPVVKIVDPAKIEIPKYTVERNPLREFIIKVWNKSTCPDGSLCPNSFPCCLFAPGQYFCC 482
++P Y V+ +K + +CP+G + CC G + CC
Sbjct: 264 -----YTTDLLTKLPGYPVKE-------VKCDMEVSCPEG------YTCCRLNTGAWGCC 305
Query: 483 PFPGGVCCSSPPGCVPSGQQC 545
PF VCC C P+G QC
Sbjct: 306 PFAKAVCCEDHIHCCPAGFQC 326
Score = 98.6 bits (244), Expect = 1e-20
Identities = 46/137 (33%), Positives = 59/137 (43%), Gaps = 1/137 (0%)
Frame = +3
Query: 138 CGDQKTCCVSKSGGHQCCQYPNAVCCGDQMHCCPEGTTCDLVNKRCIHQSNEPIEWPVVK 317
C D TCC+ G CC P A CC D++HCCP G +CDLV+ RC+ +
Sbjct: 132 CPDSATCCIMVDGSWGCCPMPQASCCEDRVHCCPHGASCDLVHTRCVSPTG--------- 182
Query: 318 IVDPAKIEIPKYTVERNPLREFIIKVWNKSTCPDG-SLCPNSFPCCLFAPGQYFCCPFPG 494
+ P R F + CPD + CP+ CC G+Y CCP P
Sbjct: 183 -THTLLKKFPAQKTNRAVSLPFSV------VCPDAKTQCPDDSTCCELPTGKYGCCPMPN 235
Query: 495 GVCCSSPPGCVPSGQQC 545
+CCS C P C
Sbjct: 236 AICCSDHLHCCPQDTVC 252
Score = 92.4 bits (228), Expect = 9e-19
Identities = 46/151 (30%), Positives = 64/151 (42%)
Frame = +3
Query: 108 KNARQNGKALCGDQKTCCVSKSGGHQCCQYPNAVCCGDQMHCCPEGTTCDLVNKRCIHQS 287
K + + + C + TCC +G CC + AVCC D +HCCP G C C
Sbjct: 278 KEVKCDMEVSCPEGYTCCRLNTGAWGCCPFAKAVCCEDHIHCCPAGFQCHTEKGTC-EMG 336
Query: 288 NEPIEWPVVKIVDPAKIEIPKYTVERNPLREFIIKVWNKSTCPDGSLCPNSFPCCLFAPG 467
+ W + K++ P ++ P+ P C D + CP + CC G
Sbjct: 337 ILQVPW-MKKVIAPLRLPDPQILKSDTP-------------CDDFTRCPTNNTCCKLNSG 382
Query: 468 QYFCCPFPGGVCCSSPPGCVPSGQQCLSG*Y 560
+ CCP P VCCS C P G CL+ Y
Sbjct: 383 DWGCCPIPEAVCCSDNQHCCPQGFTCLAQGY 413
Score = 91.3 bits (225), Expect = 2e-18
Identities = 47/136 (34%), Positives = 64/136 (47%)
Frame = +3
Query: 138 CGDQKTCCVSKSGGHQCCQYPNAVCCGDQMHCCPEGTTCDLVNKRCIHQSNEPIEWPVVK 317
C +TCC S G CCQ P+AVCC D+ HCCP G TC++ + C + + I+ PV+
Sbjct: 448 CPVGQTCCPSLKGSWACCQLPHAVCCEDRQHCCPAGYTCNVKARTC-EKDVDFIQPPVLL 506
Query: 318 IVDPAKIEIPKYTVERNPLREFIIKVWNKSTCPDGSLCPNSFPCCLFAPGQYFCCPFPGG 497
+ P KV N C +G C ++ CC + G + CCP+ G
Sbjct: 507 TLGP--------------------KVGNVE-CGEGHFCHDNQTCCKDSAGVWACCPYLKG 545
Query: 498 VCCSSPPGCVPSGQQC 545
VCC C P G C
Sbjct: 546 VCCRDGRHCCPGGFHC 561
Score = 81.3 bits (199), Expect = 2e-15
Identities = 47/136 (34%), Positives = 57/136 (41%)
Frame = +3
Query: 138 CGDQKTCCVSKSGGHQCCQYPNAVCCGDQMHCCPEGTTCDLVNKRCIHQSNEPIEWPVVK 317
C TCC SG CC P AVCC D HCCP+G TC L C Q + + + K
Sbjct: 370 CPTNNTCCKLNSGDWGCCPIPEAVCCSDNQHCCPQGFTC-LAQGYC--QKGDTMVAGLEK 426
Query: 318 IVDPAKIEIPKYTVERNPLREFIIKVWNKSTCPDGSLCPNSFPCCLFAPGQYFCCPFPGG 497
I PA+ + PL+ I C + CP CC G + CC P
Sbjct: 427 I--PAR--------QTTPLQIGDI------GCDQHTSCPVGQTCCPSLKGSWACCQLPHA 470
Query: 498 VCCSSPPGCVPSGQQC 545
VCC C P+G C
Sbjct: 471 VCCEDRQHCCPAGYTC 486
Score = 78.2 bits (191), Expect = 2e-14
Identities = 38/136 (27%), Positives = 50/136 (36%)
Frame = +3
Query: 138 CGDQKTCCVSKSGGHQCCQYPNAVCCGDQMHCCPEGTTCDLVNKRCIHQSNEPIEWPVVK 317
C +C ++ SG CC + V CGD HCCP+G C K C S+ P+
Sbjct: 67 CPAGYSCLLTVSGTSSCCPFSKGVSCGDGYHCCPQGFHCSADGKSCFQMSDNPL------ 120
Query: 318 IVDPAKIEIPKYTVERNPLREFIIKVWNKSTCPDGSLCPNSFPCCLFAPGQYFCCPFPGG 497
++ P E CP+S CC+ G + CCP P
Sbjct: 121 ----GAVQCPGSQFE----------------------CPDSATCCIMVDGSWGCCPMPQA 154
Query: 498 VCCSSPPGCVPSGQQC 545
CC C P G C
Sbjct: 155 SCCEDRVHCCPHGASC 170
Score = 55.1 bits (131), Expect = 2e-07
Identities = 20/49 (40%), Positives = 25/49 (51%)
Frame = +3
Query: 138 CGDQKTCCVSKSGGHQCCQYPNAVCCGDQMHCCPEGTTCDLVNKRCIHQ 284
C D +TCC +G CC Y VCC D HCCP G C +C+ +
Sbjct: 523 CHDNQTCCKDSAGVWACCPYLKGVCCRDGRHCCPGGFHCSARGTKCLRK 571
Score = 41.2 bits (95), Expect = 0.002
Identities = 17/46 (36%), Positives = 19/46 (41%)
Frame = +3
Query: 408 TCPDGSLCPNSFPCCLFAPGQYFCCPFPGGVCCSSPPGCVPSGQQC 545
+C CP + C L G CCPF GV C C P G C
Sbjct: 60 SCQTHGHCPAGYSCLLTVSGTSSCCPFSKGVSCGDGYHCCPQGFHC 105
>sp|P28799|GRN_HUMAN Granulins precursor (Proepithelin) (PEPI) [Contains: Acrogranin;
Paragranulin; Granulin-1 (Granulin G); Granulin-2
(Granulin F); Granulin-3 (Granulin B); Granulin-4
(Granulin A); Granulin-5 (Granulin C); Granulin-6
(Granulin D); Granulin-7 (Granulin E)]
Length = 593
Score = 102 bits (253), Expect = 1e-21
Identities = 47/141 (33%), Positives = 67/141 (47%)
Frame = +3
Query: 123 NGKALCGDQKTCCVSKSGGHQCCQYPNAVCCGDQMHCCPEGTTCDLVNKRCIHQSNEPIE 302
+ ++ C D TCC SG + CC PNA CC D +HCCP+ T CDL+ +C+ + N +
Sbjct: 210 DARSRCPDGSTCCELPSGKYGCCPMPNATCCSDHLHCCPQDTVCDLIQSKCLSKENATTD 269
Query: 303 WPVVKIVDPAKIEIPKYTVERNPLREFIIKVWNKSTCPDGSLCPNSFPCCLFAPGQYFCC 482
++P +TV +K + +CPDG + CC G + CC
Sbjct: 270 ---------LLTKLPAHTVGD-------VKCDMEVSCPDG------YTCCRLQSGAWGCC 307
Query: 483 PFPGGVCCSSPPGCVPSGQQC 545
PF VCC C P+G C
Sbjct: 308 PFTQAVCCEDHIHCCPAGFTC 328
Score = 100 bits (250), Expect = 3e-21
Identities = 49/137 (35%), Positives = 60/137 (43%), Gaps = 1/137 (0%)
Frame = +3
Query: 138 CGDQKTCCVSKSGGHQCCQYPNAVCCGDQMHCCPEGTTCDLVNKRCIHQSNEPIEWPVVK 317
C D TCCV G CC P A CC D++HCCP G CDLV+ RCI +
Sbjct: 133 CPDFSTCCVMVDGSWGCCPMPQASCCEDRVHCCPHGAFCDLVHTRCITPTG--------- 183
Query: 318 IVDPAKIEIPKYTVERNPLREFIIKVWNKSTCPDG-SLCPNSFPCCLFAPGQYFCCPFPG 494
P ++P R + + + CPD S CP+ CC G+Y CCP P
Sbjct: 184 -THPLAKKLPAQRTNR------AVALSSSVMCPDARSRCPDGSTCCELPSGKYGCCPMPN 236
Query: 495 GVCCSSPPGCVPSGQQC 545
CCS C P C
Sbjct: 237 ATCCSDHLHCCPQDTVC 253
Score = 99.0 bits (245), Expect = 1e-20
Identities = 48/138 (34%), Positives = 62/138 (44%)
Frame = +3
Query: 138 CGDQKTCCVSKSGGHQCCQYPNAVCCGDQMHCCPEGTTCDLVNKRCIHQSNEPIEWPVVK 317
C D TCC +SG CC + AVCC D +HCCP G TCD C Q + W
Sbjct: 290 CPDGYTCCRLQSGAWGCCPFTQAVCCEDHIHCCPAGFTCDTQKGTC-EQGPHQVPWMEKA 348
Query: 318 IVDPAKIEIPKYTVERNPLREFIIKVWNKSTCPDGSLCPNSFPCCLFAPGQYFCCPFPGG 497
PA + +P + + C + S CP+S CC G++ CCP P
Sbjct: 349 ---PAHLSLPDPQALKRDV-----------PCDNVSSCPSSDTCCQLTSGEWGCCPIPEA 394
Query: 498 VCCSSPPGCVPSGQQCLS 551
VCCS C P G C++
Sbjct: 395 VCCSDHQHCCPQGYTCVA 412
Score = 84.0 bits (206), Expect = 3e-16
Identities = 47/137 (34%), Positives = 63/137 (45%), Gaps = 1/137 (0%)
Frame = +3
Query: 138 CGDQKTCCVSKSGGHQCCQYPNAVCCGDQMHCCPEGTTCDLVNKRCIHQSNEPIEWPVVK 317
C +TCC S G CCQ P+AVCC D+ HCCP G TC++ + C E VV
Sbjct: 450 CPVGQTCCPSLGGSWACCQLPHAVCCEDRQHCCPAGYTCNVKARSC--------EKEVVS 501
Query: 318 IVDPAKIEIPKYTVERNPLREFIIKVWNKST-CPDGSLCPNSFPCCLFAPGQYFCCPFPG 494
P + R+P V K C +G C ++ CC + CCP+
Sbjct: 502 AQ-------PATFLARSP------HVGVKDVECGEGHFCHDNQTCCRDNRQGWACCPYRQ 548
Query: 495 GVCCSSPPGCVPSGQQC 545
GVCC+ C P+G +C
Sbjct: 549 GVCCADRRHCCPAGFRC 565
Score = 80.9 bits (198), Expect = 3e-15
Identities = 44/136 (32%), Positives = 54/136 (39%)
Frame = +3
Query: 138 CGDQKTCCVSKSGGHQCCQYPNAVCCGDQMHCCPEGTTCDLVNKRCIHQSNEPIEWPVVK 317
C TCC SG CC P AVCC D HCCP+G TC + +C S +
Sbjct: 372 CPSSDTCCQLTSGEWGCCPIPEAVCCSDHQHCCPQGYTC-VAEGQCQRGS---------E 421
Query: 318 IVDPAKIEIPKYTVERNPLREFIIKVWNKSTCPDGSLCPNSFPCCLFAPGQYFCCPFPGG 497
IV +E+ P R + C + CP CC G + CC P
Sbjct: 422 IVAG---------LEKMPARRASLSHPRDIGCDQHTSCPVGQTCCPSLGGSWACCQLPHA 472
Query: 498 VCCSSPPGCVPSGQQC 545
VCC C P+G C
Sbjct: 473 VCCEDRQHCCPAGYTC 488
Score = 76.3 bits (186), Expect = 7e-14
Identities = 39/139 (28%), Positives = 48/139 (34%), Gaps = 1/139 (0%)
Frame = +3
Query: 132 ALCGDQKTCCVSKSGGHQCCQYPNAVCCGDQMHCCPEGTTCDLVNKRCIHQSNEPIEWPV 311
A C +C + SG CC +P AV CGD HCCP G C + C +S +
Sbjct: 65 AHCSAGHSCIFTVSGTSSCCPFPEAVACGDGHHCCPRGFHCSADGRSCFQRSGNNSVGAI 124
Query: 312 VKIVDPAKIEIPKYTVERNPLREFIIKVWNKSTCPDGSL-CPNSFPCCLFAPGQYFCCPF 488
CPD CP+ CC+ G + CCP
Sbjct: 125 --------------------------------QCPDSQFECPDFSTCCVMVDGSWGCCPM 152
Query: 489 PGGVCCSSPPGCVPSGQQC 545
P CC C P G C
Sbjct: 153 PQASCCEDRVHCCPHGAFC 171
Score = 57.0 bits (136), Expect = 4e-08
Identities = 25/65 (38%), Positives = 31/65 (47%)
Frame = +3
Query: 138 CGDQKTCCVSKSGGHQCCQYPNAVCCGDQMHCCPEGTTCDLVNKRCIHQSNEPIEWPVVK 317
C D +TCC G CC Y VCC D+ HCCP G C +C+ + E W
Sbjct: 527 CHDNQTCCRDNRQGWACCPYRQGVCCADRRHCCPAGFRCAARGTKCLRR--EAPRWD-AP 583
Query: 318 IVDPA 332
+ DPA
Sbjct: 584 LRDPA 588
Score = 35.8 bits (81), Expect = 0.100
Identities = 15/45 (33%), Positives = 16/45 (35%)
Frame = +3
Query: 411 CPDGSLCPNSFPCCLFAPGQYFCCPFPGGVCCSSPPGCVPSGQQC 545
C + C C G CCPFP V C C P G C
Sbjct: 61 CQVDAHCSAGHSCIFTVSGTSSCCPFPEAVACGDGHHCCPRGFHC 105
>sp|P80059|PMD1_LOCMI Pars intercerebralis major peptide D1 (PMP-D1)
Length = 54
Score = 62.8 bits (151), Expect = 8e-10
Identities = 23/47 (48%), Positives = 28/47 (59%)
Frame = +3
Query: 138 CGDQKTCCVSKSGGHQCCQYPNAVCCGDQMHCCPEGTTCDLVNKRCI 278
C +TCC + G CC Y VCC D +HCCP GT CD ++RCI
Sbjct: 7 CPGTETCCTTPQGEEGCCPYKEGVCCLDGIHCCPSGTVCDEDHRRCI 53
Score = 44.7 bits (104), Expect = 2e-04
Identities = 17/39 (43%), Positives = 20/39 (51%)
Frame = +3
Query: 429 CPNSFPCCLFAPGQYFCCPFPGGVCCSSPPGCVPSGQQC 545
CP + CC G+ CCP+ GVCC C PSG C
Sbjct: 7 CPGTETCCTTPQGEEGCCPYKEGVCCLDGIHCCPSGTVC 45
>sp|P80930|ENA1_HORSE Antimicrobial peptide eNAP-1
Length = 46
Score = 57.0 bits (136), Expect = 4e-08
Identities = 20/36 (55%), Positives = 22/36 (61%)
Frame = +3
Query: 138 CGDQKTCCVSKSGGHQCCQYPNAVCCGDQMHCCPEG 245
C D +TCC + GG CC Y VCC DQ HCCP G
Sbjct: 10 CHDXQTCCRASQGGXACCPYSQGVCCADQRHCCPVG 45
Score = 43.1 bits (100), Expect = 6e-04
Identities = 16/42 (38%), Positives = 21/42 (50%)
Frame = +3
Query: 411 CPDGSLCPNSFPCCLFAPGQYFCCPFPGGVCCSSPPGCVPSG 536
C +G C + CC + G CCP+ GVCC+ C P G
Sbjct: 4 CGEGHFCHDXQTCCRASQGGXACCPYSQGVCCADQRHCCPVG 45
>sp|P81013|GRN1_CYPCA Granulin-1
Length = 57
Score = 52.0 bits (123), Expect = 1e-06
Identities = 19/48 (39%), Positives = 25/48 (52%)
Frame = +3
Query: 135 LCGDQKTCCVSKSGGHQCCQYPNAVCCGDQMHCCPEGTTCDLVNKRCI 278
+C D TCC+S G CC + CC D +HCC G CD + C+
Sbjct: 9 ICPDGTTCCLSPYGVWYCCPFSMGQCCRDGIHCCRHGYHCDSTSTHCL 56
Score = 46.2 bits (108), Expect = 7e-05
Identities = 17/45 (37%), Positives = 22/45 (48%)
Frame = +3
Query: 411 CPDGSLCPNSFPCCLFAPGQYFCCPFPGGVCCSSPPGCVPSGQQC 545
C ++CP+ CCL G ++CCPF G CC C G C
Sbjct: 4 CDAATICPDGTTCCLSPYGVWYCCPFSMGQCCRDGIHCCRHGYHC 48
>sp|P81014|GRN2_CYPCA Granulin-2
Length = 57
Score = 49.3 bits (116), Expect = 9e-06
Identities = 19/52 (36%), Positives = 24/52 (46%)
Frame = +3
Query: 123 NGKALCGDQKTCCVSKSGGHQCCQYPNAVCCGDQMHCCPEGTTCDLVNKRCI 278
N + C + TCC S G CC + CC D HCC G CD + C+
Sbjct: 5 NARTTCPSRTTCCRSPFGVWYCCPFLMGQCCRDGRHCCRHGYRCDSTSTLCL 56
Score = 40.8 bits (94), Expect = 0.003
Identities = 16/45 (35%), Positives = 21/45 (46%)
Frame = +3
Query: 411 CPDGSLCPNSFPCCLFAPGQYFCCPFPGGVCCSSPPGCVPSGQQC 545
C + CP+ CC G ++CCPF G CC C G +C
Sbjct: 4 CNARTTCPSRTTCCRSPFGVWYCCPFLMGQCCRDGRHCCRHGYRC 48
>sp|P81015|GRN3_CYPCA Granulin-3
Length = 57
Score = 45.1 bits (105), Expect = 2e-04
Identities = 18/47 (38%), Positives = 21/47 (44%)
Frame = +3
Query: 138 CGDQKTCCVSKSGGHQCCQYPNAVCCGDQMHCCPEGTTCDLVNKRCI 278
C TCC S G CC + CC D HCC G CD + C+
Sbjct: 10 CPSGTTCCRSPFGVWYCCPFLMGQCCRDGRHCCRHGYHCDSTSTLCL 56
Score = 43.1 bits (100), Expect = 6e-04
Identities = 17/45 (37%), Positives = 20/45 (44%)
Frame = +3
Query: 411 CPDGSLCPNSFPCCLFAPGQYFCCPFPGGVCCSSPPGCVPSGQQC 545
C G CP+ CC G ++CCPF G CC C G C
Sbjct: 4 CDAGITCPSGTTCCRSPFGVWYCCPFLMGQCCRDGRHCCRHGYHC 48
>sp|P43297|RD21A_ARATH Cysteine proteinase RD21a precursor (RD21)
Length = 462
Score = 42.7 bits (99), Expect = 8e-04
Identities = 22/66 (33%), Positives = 25/66 (37%), Gaps = 6/66 (9%)
Frame = +3
Query: 138 CGDQKTCCVSKSGGHQC-----CQYPNAVCCGDQMHCCP-EGTTCDLVNKRCIHQSNEPI 299
C + TCC G C C A CC D CCP E CDL C+ N P
Sbjct: 381 CPESNTCCCLFEYGKYCFAWGCCPLEAATCCDDNYSCCPHEYPVCDLDQGTCLLSKNSPF 440
Query: 300 EWPVVK 317
+K
Sbjct: 441 SVKALK 446
Score = 38.9 bits (89), Expect = 0.012
Identities = 17/45 (37%), Positives = 20/45 (44%), Gaps = 4/45 (8%)
Frame = +3
Query: 408 TCPDGSLCPNSFPCCLFAPGQYF----CCPFPGGVCCSSPPGCVP 530
TCP+ + C CCLF G+Y CCP CC C P
Sbjct: 380 TCPESNTC-----CCLFEYGKYCFAWGCCPLEAATCCDDNYSCCP 419
Database: Non-redundant SwissProt sequences
Posted date: Dec 6, 2005 7:40 AM
Number of letters in database: 68,354,980
Number of sequences in database: 184,735
Database: swissprot.01
Posted date: Dec 6, 2005 8:18 AM
Number of letters in database: 66,202,850
Number of sequences in database: 184,431
Lambda K H
0.318 0.134 0.401
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 81,986,090
Number of Sequences: 369166
Number of extensions: 1937510
Number of successful extensions: 6025
Number of sequences better than 10.0: 10
Number of HSP's better than 10.0 without gapping: 5189
Number of HSP's successfully gapped in prelim test: 0
Number of HSP's that attempted gapping in prelim test: 0
Number of HSP's gapped (non-prelim): 5907
length of database: 68,354,980
effective HSP length: 106
effective length of database: 48,773,070
effective search space used: 5413810770
frameshift window, decay const: 40, 0.1
T: 12
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)