Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= Dr_sW_006_N04
(845 letters)
Database: Non-redundant SwissProt sequences
184,735 sequences; 68,354,980 total letters
Score E
Sequences producing significant alignments: (bits) Value
sp|O61998|HSP90_BRUPA Heat shock protein 90 305 8e-83
sp|P07901|HS90A_MOUSE Heat shock protein HSP 90-alpha (HSP ... 300 3e-81
sp|P07900|HS90A_HUMAN Heat shock protein HSP 90-alpha (HSP 86) 299 6e-81
sp|P08238|HS90B_HUMAN Heat shock protein HSP 90-beta (HSP 8... 299 6e-81
sp|Q9GKX8|HS90B_HORSE Heat shock protein HSP 90-beta (HSP 84) 299 7e-81
sp|P46633|HS90A_CRIGR Heat shock protein HSP 90-alpha (HSP 86) 299 7e-81
sp|O57521|HS90B_BRARE Heat shock protein HSP 90-beta 298 2e-80
sp|O02705|HS90A_PIG Heat shock protein HSP 90-alpha (HSP 86) 298 2e-80
sp|P11501|HS90A_CHICK Heat shock protein HSP 90-alpha 297 2e-80
sp|P11499|HS90B_MOUSE Heat shock protein HSP 90-beta (HSP 8... 297 3e-80
>sp|O61998|HSP90_BRUPA Heat shock protein 90
Length = 717
Score = 305 bits (782), Expect = 8e-83
Identities = 163/241 (67%), Positives = 189/241 (78%), Gaps = 5/241 (2%)
Frame = -2
Query: 793 GESKDNVNHSAFVERLTKRGFEVLLMVDPIDEYSVQQLKEYDGKKLVCVTXXXXXXXXXX 614
GES++ V SAFVER+ +RGFEV+ M DPIDEY VQQLKEYDGKKLV VT
Sbjct: 478 GESREAVASSAFVERVKRRGFEVIYMTDPIDEYCVQQLKEYDGKKLVSVTKEGLELPESE 537
Query: 613 XXXXXXXXXXXXXXPLCKVMKDILDKKVEKVTVSNRLVSSPCCIVTSQYGWSANMERIMK 434
LCKVMKDIL+KKVEKV VSNRLVSSPCCIVTS+YGWSANMERIMK
Sbjct: 538 EEKKKFEEDKVKFENLCKVMKDILEKKVEKVAVSNRLVSSPCCIVTSEYGWSANMERIMK 597
Query: 433 AQALRDSSTMGYMAAKKHLEINPDHSIMKTLKARVDADKNDKSVKDLVMLLYETSLLSSG 254
AQALRDSSTMGYMAAKKHLEINPDHS++K L+ RV+ADKNDK+VKDLV+LL+ET+LLSSG
Sbjct: 598 AQALRDSSTMGYMAAKKHLEINPDHSVIKALRERVEADKNDKTVKDLVVLLFETALLSSG 657
Query: 253 FTLEDPQVHGNRIHRMIKLGLGI-EDDDVEMDATEAGD----VPVVASTAEEDAGKMEEV 89
F+LEDPQ+H +RI+RMIKLGL I ED++ E A+ +G+ VP + AEEDA +MEEV
Sbjct: 658 FSLEDPQLHASRIYRMIKLGLDITEDEEEEAIASVSGEKDECVPNLVG-AEEDASRMEEV 716
Query: 88 D 86
D
Sbjct: 717 D 717
>sp|P07901|HS90A_MOUSE Heat shock protein HSP 90-alpha (HSP 86) (Tumor specific
transplantation 86 kDa antigen) (TSTA)
Length = 733
Score = 300 bits (769), Expect = 3e-81
Identities = 154/248 (62%), Positives = 188/248 (75%), Gaps = 3/248 (1%)
Frame = -2
Query: 820 SERNTKMARGESKDNVNHSAFVERLTKRGFEVLLMVDPIDEYSVQQLKEYDGKKLVCVTX 641
++++ GE+KD V +SAFVERL K G EV+ M++PIDEY VQQLKE++GK LV VT
Sbjct: 488 NQKHIYFITGETKDQVANSAFVERLRKHGLEVIYMIEPIDEYCVQQLKEFEGKTLVSVTK 547
Query: 640 XXXXXXXXXXXXXXXXXXXXXXXPLCKVMKDILDKKVEKVTVSNRLVSSPCCIVTSQYGW 461
LCK+MKDIL+KKVEKV VSNRLV+SPCCIVTS YGW
Sbjct: 548 EGLELPEDEEEKKKQEEKKTKFENLCKIMKDILEKKVEKVVVSNRLVTSPCCIVTSTYGW 607
Query: 460 SANMERIMKAQALRDSSTMGYMAAKKHLEINPDHSIMKTLKARVDADKNDKSVKDLVMLL 281
+ANMERIMKAQALRD+STMGYMAAKKHLEINPDHSI++TL+ + +ADKNDKSVKDLV+LL
Sbjct: 608 TANMERIMKAQALRDNSTMGYMAAKKHLEINPDHSIIETLRQKAEADKNDKSVKDLVILL 667
Query: 280 YETSLLSSGFTLEDPQVHGNRIHRMIKLGLGIEDDDVEMDATEAG---DVPVVASTAEED 110
YET+LLSSGF+LEDPQ H NRI+RMIKLGLGI++DD +D T A ++P + ++D
Sbjct: 668 YETALLSSGFSLEDPQTHANRIYRMIKLGLGIDEDDPTVDDTSAAVTEEMPPL--EGDDD 725
Query: 109 AGKMEEVD 86
+MEEVD
Sbjct: 726 TSRMEEVD 733
>sp|P07900|HS90A_HUMAN Heat shock protein HSP 90-alpha (HSP 86)
Length = 732
Score = 299 bits (766), Expect = 6e-81
Identities = 154/239 (64%), Positives = 183/239 (76%), Gaps = 3/239 (1%)
Frame = -2
Query: 793 GESKDNVNHSAFVERLTKRGFEVLLMVDPIDEYSVQQLKEYDGKKLVCVTXXXXXXXXXX 614
GE+KD V +SAFVERL K G EV+ M++PIDEY VQQLKE++GK LV VT
Sbjct: 496 GETKDQVANSAFVERLRKHGLEVIYMIEPIDEYCVQQLKEFEGKTLVSVTKEGLELPEDE 555
Query: 613 XXXXXXXXXXXXXXPLCKVMKDILDKKVEKVTVSNRLVSSPCCIVTSQYGWSANMERIMK 434
LCK+MKDIL+KKVEKV VSNRLV+SPCCIVTS YGW+ANMERIMK
Sbjct: 556 EEKKKQEEKKTKFENLCKIMKDILEKKVEKVVVSNRLVTSPCCIVTSTYGWTANMERIMK 615
Query: 433 AQALRDSSTMGYMAAKKHLEINPDHSIMKTLKARVDADKNDKSVKDLVMLLYETSLLSSG 254
AQALRD+STMGYMAAKKHLEINPDHSI++TL+ + +ADKNDKSVKDLV+LLYET+LLSSG
Sbjct: 616 AQALRDNSTMGYMAAKKHLEINPDHSIIETLRQKAEADKNDKSVKDLVILLYETALLSSG 675
Query: 253 FTLEDPQVHGNRIHRMIKLGLGIEDDDVEMDATEAG---DVPVVASTAEEDAGKMEEVD 86
F+LEDPQ H NRI+RMIKLGLGI++DD D T A ++P + ++D +MEEVD
Sbjct: 676 FSLEDPQTHANRIYRMIKLGLGIDEDDPTADDTSAAVTEEMPPL--EGDDDTSRMEEVD 732
>sp|P08238|HS90B_HUMAN Heat shock protein HSP 90-beta (HSP 84) (HSP 90)
Length = 724
Score = 299 bits (766), Expect = 6e-81
Identities = 154/239 (64%), Positives = 185/239 (77%), Gaps = 3/239 (1%)
Frame = -2
Query: 793 GESKDNVNHSAFVERLTKRGFEVLLMVDPIDEYSVQQLKEYDGKKLVCVTXXXXXXXXXX 614
GESK+ V +SAFVER+ KRGFEV+ M +PIDEY VQQLKE+DGK LV VT
Sbjct: 488 GESKEQVANSAFVERVRKRGFEVVYMTEPIDEYCVQQLKEFDGKSLVSVTKEGLELPEDE 547
Query: 613 XXXXXXXXXXXXXXPLCKVMKDILDKKVEKVTVSNRLVSSPCCIVTSQYGWSANMERIMK 434
LCK+MK+ILDKKVEKVT+SNRLVSSPCCIVTS YGW+ANMERIMK
Sbjct: 548 EEKKKMEESKAKFENLCKLMKEILDKKVEKVTISNRLVSSPCCIVTSTYGWTANMERIMK 607
Query: 433 AQALRDSSTMGYMAAKKHLEINPDHSIMKTLKARVDADKNDKSVKDLVMLLYETSLLSSG 254
AQALRD+STMGYM AKKHLEINPDH I++TL+ + +ADKNDK+VKDLV+LL+ET+LLSSG
Sbjct: 608 AQALRDNSTMGYMMAKKHLEINPDHPIVETLRQKAEADKNDKAVKDLVVLLFETALLSSG 667
Query: 253 FTLEDPQVHGNRIHRMIKLGLGIEDDDV---EMDATEAGDVPVVASTAEEDAGKMEEVD 86
F+LEDPQ H NRI+RMIKLGLGI++D+V E +A ++P + +EDA +MEEVD
Sbjct: 668 FSLEDPQTHSNRIYRMIKLGLGIDEDEVAAEEPNAAVPDEIPPL--EGDEDASRMEEVD 724
>sp|Q9GKX8|HS90B_HORSE Heat shock protein HSP 90-beta (HSP 84)
Length = 724
Score = 299 bits (765), Expect = 7e-81
Identities = 154/239 (64%), Positives = 184/239 (76%), Gaps = 3/239 (1%)
Frame = -2
Query: 793 GESKDNVNHSAFVERLTKRGFEVLLMVDPIDEYSVQQLKEYDGKKLVCVTXXXXXXXXXX 614
GESK+ V +SAFVER+ KRGFEV+ M +PIDEY VQQLKE+DGK LV VT
Sbjct: 488 GESKEQVANSAFVERVRKRGFEVVYMTEPIDEYCVQQLKEFDGKSLVSVTKEGLELPEDE 547
Query: 613 XXXXXXXXXXXXXXPLCKVMKDILDKKVEKVTVSNRLVSSPCCIVTSQYGWSANMERIMK 434
LCK+MK+ILDKKVEKVT+SNRLVSSPCCIVTS YGW+ANMERIMK
Sbjct: 548 EEKKKMEESKAKFENLCKLMKEILDKKVEKVTISNRLVSSPCCIVTSTYGWTANMERIMK 607
Query: 433 AQALRDSSTMGYMAAKKHLEINPDHSIMKTLKARVDADKNDKSVKDLVMLLYETSLLSSG 254
AQALRD+STMGYM AKKHLEINPDH I++TL+ + +ADKNDK+VKDLV+LL+ET+LLSSG
Sbjct: 608 AQALRDNSTMGYMMAKKHLEINPDHPIVETLRQKAEADKNDKAVKDLVVLLFETALLSSG 667
Query: 253 FTLEDPQVHGNRIHRMIKLGLGIEDDDV---EMDATEAGDVPVVASTAEEDAGKMEEVD 86
F+LEDPQ H NRI+RMIKLGLGI++D+V E A ++P + +EDA +MEEVD
Sbjct: 668 FSLEDPQTHSNRIYRMIKLGLGIDEDEVAAEEPSAAVPDEIPPL--EGDEDASRMEEVD 724
>sp|P46633|HS90A_CRIGR Heat shock protein HSP 90-alpha (HSP 86)
Length = 733
Score = 299 bits (765), Expect = 7e-81
Identities = 153/248 (61%), Positives = 188/248 (75%), Gaps = 3/248 (1%)
Frame = -2
Query: 820 SERNTKMARGESKDNVNHSAFVERLTKRGFEVLLMVDPIDEYSVQQLKEYDGKKLVCVTX 641
++++ GE+KD V +SAFVERL K G EV+ M++PIDEY VQQLKE++GK LV VT
Sbjct: 488 NQKHIYFITGETKDQVANSAFVERLRKHGLEVIYMIEPIDEYCVQQLKEFEGKTLVSVTK 547
Query: 640 XXXXXXXXXXXXXXXXXXXXXXXPLCKVMKDILDKKVEKVTVSNRLVSSPCCIVTSQYGW 461
LCK+MKDIL+KKVEKV VSNRLV+SPCCIVTS YGW
Sbjct: 548 EGLELPEDEEEKKKQEEKKTKFENLCKIMKDILEKKVEKVVVSNRLVTSPCCIVTSTYGW 607
Query: 460 SANMERIMKAQALRDSSTMGYMAAKKHLEINPDHSIMKTLKARVDADKNDKSVKDLVMLL 281
+ANMERI+KAQALRD+STMGYMAAKKHLEINPDHSI++TL+ + +ADKNDKSVKDLV+LL
Sbjct: 608 TANMERIIKAQALRDNSTMGYMAAKKHLEINPDHSIIETLRQKAEADKNDKSVKDLVILL 667
Query: 280 YETSLLSSGFTLEDPQVHGNRIHRMIKLGLGIEDDDVEMDATEAG---DVPVVASTAEED 110
YET+LLSSGF+LEDPQ H NRI+RMIKLGLGI++DD +D T A ++P + ++D
Sbjct: 668 YETALLSSGFSLEDPQTHANRIYRMIKLGLGIDEDDPTVDDTSAAVTEEMPPL--EGDDD 725
Query: 109 AGKMEEVD 86
+MEEVD
Sbjct: 726 TSRMEEVD 733
>sp|O57521|HS90B_BRARE Heat shock protein HSP 90-beta
Length = 725
Score = 298 bits (762), Expect = 2e-80
Identities = 153/239 (64%), Positives = 180/239 (75%), Gaps = 3/239 (1%)
Frame = -2
Query: 793 GESKDNVNHSAFVERLTKRGFEVLLMVDPIDEYSVQQLKEYDGKKLVCVTXXXXXXXXXX 614
GESKD V HSAFVER+ KRGFEVL M +PIDEY VQQLK++DGK LV VT
Sbjct: 487 GESKDQVAHSAFVERVCKRGFEVLYMTEPIDEYCVQQLKDFDGKSLVSVTKEGLELPEDE 546
Query: 613 XXXXXXXXXXXXXXPLCKVMKDILDKKVEKVTVSNRLVSSPCCIVTSQYGWSANMERIMK 434
LCK+MK+ILDKKVEKVTVSNRLVSSPCCIVTS YGW+ANMERIMK
Sbjct: 547 DEKKKMEEDKAKFENLCKLMKEILDKKVEKVTVSNRLVSSPCCIVTSTYGWTANMERIMK 606
Query: 433 AQALRDSSTMGYMAAKKHLEINPDHSIMKTLKARVDADKNDKSVKDLVMLLYETSLLSSG 254
AQALRD+STMGYM A KHLEINPDH IM+TL+ + +ADKN K+VKDLV+LL+ET+LLSSG
Sbjct: 607 AQALRDNSTMGYMMANKHLEINPDHPIMETLRQKAEADKNTKAVKDLVILLFETALLSSG 666
Query: 253 FTLEDPQVHGNRIHRMIKLGLGIEDDD---VEMDATEAGDVPVVASTAEEDAGKMEEVD 86
F+L+DPQ H NRI+RMIKLGLGI++D+ VE + A + ++DA +MEEVD
Sbjct: 667 FSLDDPQTHSNRIYRMIKLGLGIDEDEDVPVEEPTSAAAPEDIPPLEGDDDASRMEEVD 725
>sp|O02705|HS90A_PIG Heat shock protein HSP 90-alpha (HSP 86)
Length = 733
Score = 298 bits (762), Expect = 2e-80
Identities = 153/239 (64%), Positives = 183/239 (76%), Gaps = 3/239 (1%)
Frame = -2
Query: 793 GESKDNVNHSAFVERLTKRGFEVLLMVDPIDEYSVQQLKEYDGKKLVCVTXXXXXXXXXX 614
GE+KD V +SAFVERL K G EV+ M++PIDEY VQQLKE++GK LV VT
Sbjct: 497 GETKDQVANSAFVERLRKHGLEVIYMIEPIDEYCVQQLKEFEGKTLVSVTKEGLELPEDE 556
Query: 613 XXXXXXXXXXXXXXPLCKVMKDILDKKVEKVTVSNRLVSSPCCIVTSQYGWSANMERIMK 434
LCK+MKDIL+KKVEKV VSNRLV+SPCCIVTS YGW+ANMERIMK
Sbjct: 557 EEKKKQEEKKTKFENLCKIMKDILEKKVEKVVVSNRLVTSPCCIVTSTYGWTANMERIMK 616
Query: 433 AQALRDSSTMGYMAAKKHLEINPDHSIMKTLKARVDADKNDKSVKDLVMLLYETSLLSSG 254
AQALRD+STMGYMAAKKHLEINPDHSI++TL+ + +ADKNDKSVKDLV+LLYET+LLSSG
Sbjct: 617 AQALRDNSTMGYMAAKKHLEINPDHSIIETLRQKAEADKNDKSVKDLVILLYETALLSSG 676
Query: 253 FTLEDPQVHGNRIHRMIKLGLGIEDDDVEMDATEAG---DVPVVASTAEEDAGKMEEVD 86
F+LEDPQ H NRI+RMIKLGLGI++DD D + A ++P + ++D +MEEVD
Sbjct: 677 FSLEDPQTHANRIYRMIKLGLGIDEDDPTADDSSAAVTEEMPPL--EGDDDTSRMEEVD 733
>sp|P11501|HS90A_CHICK Heat shock protein HSP 90-alpha
Length = 728
Score = 297 bits (761), Expect = 2e-80
Identities = 152/246 (61%), Positives = 185/246 (75%), Gaps = 1/246 (0%)
Frame = -2
Query: 820 SERNTKMARGESKDNVNHSAFVERLTKRGFEVLLMVDPIDEYSVQQLKEYDGKKLVCVTX 641
++++ GE+KD V +SAFVERL K G EV+ M++PIDEY VQQLKE++GK LV VT
Sbjct: 483 NQKHVYYITGETKDQVANSAFVERLRKHGLEVIYMIEPIDEYCVQQLKEFEGKTLVSVTK 542
Query: 640 XXXXXXXXXXXXXXXXXXXXXXXPLCKVMKDILDKKVEKVTVSNRLVSSPCCIVTSQYGW 461
LCK+MKDIL+KKVEKV VSNRLV+SPCCIVTS YGW
Sbjct: 543 EGLELPEDEEEKKKQEEKKAKFENLCKIMKDILEKKVEKVVVSNRLVTSPCCIVTSTYGW 602
Query: 460 SANMERIMKAQALRDSSTMGYMAAKKHLEINPDHSIMKTLKARVDADKNDKSVKDLVMLL 281
+ANMERIMKAQALRD+STMGYMAAKKHLEINPDHSI++TL+ + +ADKNDKSVKDLV+LL
Sbjct: 603 TANMERIMKAQALRDNSTMGYMAAKKHLEINPDHSIIETLRQKAEADKNDKSVKDLVILL 662
Query: 280 YETSLLSSGFTLEDPQVHGNRIHRMIKLGLGIEDDDVEM-DATEAGDVPVVASTAEEDAG 104
YET+LLSSGF+LEDPQ H NRI+RMIKLGLGI++DD +A+ A + ++D
Sbjct: 663 YETALLSSGFSLEDPQTHANRIYRMIKLGLGIDEDDTAAEEASPAVTEEMPPLEGDDDTS 722
Query: 103 KMEEVD 86
+MEEVD
Sbjct: 723 RMEEVD 728
>sp|P11499|HS90B_MOUSE Heat shock protein HSP 90-beta (HSP 84) (Tumor-specific
transplantation 84 kDa antigen) (TSTA)
Length = 724
Score = 297 bits (760), Expect = 3e-80
Identities = 153/239 (64%), Positives = 183/239 (76%), Gaps = 3/239 (1%)
Frame = -2
Query: 793 GESKDNVNHSAFVERLTKRGFEVLLMVDPIDEYSVQQLKEYDGKKLVCVTXXXXXXXXXX 614
GESK+ V + AFVER+ KRGFEV+ M +PIDEY VQQLKE+DGK LV VT
Sbjct: 488 GESKEQVANPAFVERVRKRGFEVVYMTEPIDEYCVQQLKEFDGKSLVSVTKEGLELPEDE 547
Query: 613 XXXXXXXXXXXXXXPLCKVMKDILDKKVEKVTVSNRLVSSPCCIVTSQYGWSANMERIMK 434
LCK+MK+ILDKKVEKVT+SNRLVSSPCCIVTS YGW+ANMERIMK
Sbjct: 548 EEKKKMEESKAKFENLCKLMKEILDKKVEKVTISNRLVSSPCCIVTSTYGWTANMERIMK 607
Query: 433 AQALRDSSTMGYMAAKKHLEINPDHSIMKTLKARVDADKNDKSVKDLVMLLYETSLLSSG 254
AQALRD+STMGYM AKKHLEINPDH I++TL+ + +ADKNDK+VKDLV+LL+ET+LLSSG
Sbjct: 608 AQALRDNSTMGYMMAKKHLEINPDHPIVETLRQKAEADKNDKAVKDLVVLLFETALLSSG 667
Query: 253 FTLEDPQVHGNRIHRMIKLGLGIEDDDV---EMDATEAGDVPVVASTAEEDAGKMEEVD 86
F+LEDPQ H NRI+RMIKLGLGI++D+V E A ++P + +EDA +MEEVD
Sbjct: 668 FSLEDPQTHSNRIYRMIKLGLGIDEDEVTAEEPSAAVPDEIPPL--EGDEDASRMEEVD 724
Database: Non-redundant SwissProt sequences
Posted date: Dec 6, 2005 7:40 AM
Number of letters in database: 68,354,980
Number of sequences in database: 184,735
Database: swissprot.01
Posted date: Dec 6, 2005 8:18 AM
Number of letters in database: 66,202,850
Number of sequences in database: 184,431
Lambda K H
0.318 0.134 0.401
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 81,196,253
Number of Sequences: 369166
Number of extensions: 1432714
Number of successful extensions: 4555
Number of sequences better than 10.0: 10
Number of HSP's better than 10.0 without gapping: 4261
Number of HSP's successfully gapped in prelim test: 0
Number of HSP's that attempted gapping in prelim test: 0
Number of HSP's gapped (non-prelim): 4401
length of database: 68,354,980
effective HSP length: 109
effective length of database: 48,218,865
effective search space used: 8293644780
frameshift window, decay const: 40, 0.1
T: 12
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)