Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= Dr_sW_006_M11
(849 letters)
Database: Non-redundant SwissProt sequences
184,735 sequences; 68,354,980 total letters
Score E
Sequences producing significant alignments: (bits) Value
sp|O70352|CD82_RAT CD82 antigen (Metastasis suppressor homo... 74 5e-13
sp|P40237|CD82_MOUSE CD82 antigen (Inducible membrane prote... 74 7e-13
sp|Q80WR1|TSN18_MOUSE Tetraspanin-18 (Tspan-18) 64 7e-10
sp|O60635|TSN1_HUMAN Tetraspanin-1 (Tspan-1) (Tetraspan NET... 64 7e-10
sp|Q58CY8|TSN18_BOVIN Tetraspanin-18 (Tspan-18) 63 1e-09
sp|Q5RC27|TSN1_PONPY Tetraspanin-1 (Tspan-1) 62 3e-09
sp|Q96SJ8|TSN18_HUMAN Tetraspanin-18 (Tspan-18) 60 6e-09
sp|P27701|CD82_HUMAN CD82 antigen (Inducible membrane prote... 59 2e-08
sp|O75954|TSN9_HUMAN Tetraspanin-9 (Tspan-9) (Tetraspan NET-5) 59 2e-08
sp|Q8BJU2|TSN9_MOUSE Tetraspanin-9 (Tspan-9) (Tetraspan NET-5) 58 4e-08
>sp|O70352|CD82_RAT CD82 antigen (Metastasis suppressor homolog)
Length = 266
Score = 73.9 bits (180), Expect = 5e-13
Identities = 61/266 (22%), Positives = 113/266 (42%), Gaps = 2/266 (0%)
Frame = +2
Query: 5 IFNILFFLIGAVILGVGIWVKVDKSNLFEVIRNIKLDDTTASFNNTNSTILDVVAIVLII 184
+FN+LFF++GAVILG G+W+ DKS+ V++ T+S+ L V A V I
Sbjct: 15 LFNLLFFILGAVILGFGVWILADKSSFISVLQ-------------TSSSSLQVGAYVFIG 61
Query: 185 XXXXXXXXXXXXXXXAIKENKCLLITYSILXXXXXXXXXXXXXXXXXEKNKFQKNLGKSL 364
A+ E +CLL Y + NK ++ +G ++
Sbjct: 62 VGAITMLMGFLGCIGAVNEVRCLLGLYFVFLLLILIAQVTVEVLFYFNANKLKQEMGNTV 121
Query: 365 TNVLEKDFNGILNTNATLFTKIFTAIMFELKCCGVNNVTDFDSVRNW--KSTSSSGTKQI 538
++++ N +N +++ + + + ++KCCG + S NW + TK
Sbjct: 122 MDIIQ---NYSVNASSSR-EEAWDYVQAQVKCCG------WVSPSNWTRNPVLKNSTKTT 171
Query: 539 YPVGCCKLKEKYQYDPNKKFEYNDAKKNFENDNCPFDNDKSTININGCIPSLIDLIEKNM 718
YP C K KE+ KK + ++ + ++N P D ++ GC+ +++N
Sbjct: 172 YPCSCEKTKEEDNQLIVKK-GFCESDNSTASENSPED---WPVHPEGCMEKAQAWLQENF 227
Query: 719 XXXXXXXXXXXXFEIMCIVFACCVMR 796
E++ + + C+ R
Sbjct: 228 GILLGVCAGVAVIELLGLFLSICLCR 253
>sp|P40237|CD82_MOUSE CD82 antigen (Inducible membrane protein R2) (C33 antigen) (IA4)
Length = 266
Score = 73.6 bits (179), Expect = 7e-13
Identities = 63/267 (23%), Positives = 109/267 (40%), Gaps = 3/267 (1%)
Frame = +2
Query: 5 IFNILFFLIGAVILGVGIWVKVDKSNLFEVIRNIKLDDTTASFNNTNSTILDVVAIVLII 184
+FN+LFF++GAVILG G+W+ DK++ V++ T+S+ L V A V I
Sbjct: 15 LFNLLFFILGAVILGFGVWILADKNSFISVLQ-------------TSSSSLQVGAYVFIG 61
Query: 185 XXXXXXXXXXXXXXXAIKENKCLLITYSILXXXXXXXXXXXXXXXXXEKNKFQKNLGKSL 364
A+ E +CLL Y + +K +K +G ++
Sbjct: 62 VGAITIVMGFLGCIGAVNEVRCLLGLYFVFLLLILIAQVTVGVLFYFNADKLKKEMGNTV 121
Query: 365 TNVLEKDFNGILNTNATLF-TKIFTAIMFELKCCGVNNVTDFDSVRNWKSTSS--SGTKQ 535
+++ NAT + + + ++KCCG + S NW TK
Sbjct: 122 MDIIRN-----YTANATSSREEAWDYVQAQVKCCG------WVSHYNWTENEELMGFTKT 170
Query: 536 IYPVGCCKLKEKYQYDPNKKFEYNDAKKNFENDNCPFDNDKSTININGCIPSLIDLIEKN 715
YP C K+KE+ KK + +A + ++N P D +N GC+ +++N
Sbjct: 171 TYPCSCEKIKEEDNQLIVKK-GFCEADNSTVSENNPED---WPVNTEGCMEKAQAWLQEN 226
Query: 716 MXXXXXXXXXXXXFEIMCIVFACCVMR 796
E++ + + C+ R
Sbjct: 227 FGILLGVCAGVAVIELLGLFLSICLCR 253
>sp|Q80WR1|TSN18_MOUSE Tetraspanin-18 (Tspan-18)
Length = 248
Score = 63.5 bits (153), Expect = 7e-10
Identities = 57/265 (21%), Positives = 105/265 (39%), Gaps = 1/265 (0%)
Frame = +2
Query: 5 IFNILFFLIGAVILGVGIWVKVDKSNLFEVIRNIKLDDTTASFNNTNSTILDVVAIVLII 184
+FN FL GA +LGVGIWV VD + E++ + +L A +++
Sbjct: 15 VFNFFVFLGGACLLGVGIWVLVDPTGFREIV--------------ATNPLLTTGAYIVLA 60
Query: 185 XXXXXXXXXXXXXXXAIKENKCLLITYSILXXXXXXXXXXXXXXXXXEKNKFQKNLGKS- 361
A++EN+CLL+ + + F+++L +
Sbjct: 61 MGGLLFLLGFLGCCGAVRENRCLLLFFFLFILIIFLVELSAAILAFI----FREHLTREF 116
Query: 362 LTNVLEKDFNGILNTNATLFTKIFTAIMFELKCCGVNNVTDFDSVRNWKSTSSSGTKQIY 541
T L K + G + + +F+ + ++M CCGVN DF ++ + T+++
Sbjct: 117 FTKELTKHYQG--DNDTDVFSATWNSVMITFGCCGVNGPEDFKLASVFRLLTLD-TEEV- 172
Query: 542 PVGCCKLKEKYQYDPNKKFEYNDAKKNFENDNCPFDNDKSTININGCIPSLIDLIEKNMX 721
P CC+ +P + +++ + PF IN GC +++ E +
Sbjct: 173 PKACCR------REPQTRDGVVLSREECQLGRNPF------INKQGCYTVILNTFETYVY 220
Query: 722 XXXXXXXXXXXFEIMCIVFACCVMR 796
E+ +VFA C+ R
Sbjct: 221 LAGAFAIGVLAIELFLMVFAMCLFR 245
>sp|O60635|TSN1_HUMAN Tetraspanin-1 (Tspan-1) (Tetraspan NET-1) (Tetraspanin TM4-C)
Length = 241
Score = 63.5 bits (153), Expect = 7e-10
Identities = 55/238 (23%), Positives = 88/238 (36%)
Frame = +2
Query: 2 IIFNILFFLIGAVILGVGIWVKVDKSNLFEVIRNIKLDDTTASFNNTNSTILDVVAIVLI 181
I+FN+L FL GA +L VGIWV +D ++ ++ L + F N ++ +V
Sbjct: 12 ILFNLLIFLCGAALLAVGIWVSIDGASFLKIFG--PLSSSAMQFVNVGYFLIAAGVVVFA 69
Query: 182 IXXXXXXXXXXXXXXXAIKENKCLLITYSILXXXXXXXXXXXXXXXXXEKNKFQKNLGKS 361
+ A E+KC L+T+ + + L
Sbjct: 70 L--------GFLGCYGAKTESKCALVTFFFILLLIFIAEVAAAVVALVYTTMAEHFLTLL 121
Query: 362 LTNVLEKDFNGILNTNATLFTKIFTAIMFELKCCGVNNVTDFDSVRNWKSTSSSGTKQIY 541
+ ++KD+ + FT+++ M LKCCG N TDF+ +K S+ +
Sbjct: 122 VVPAIKKDYG-----SQEDFTQVWNTTMKGLKCCGFTNYTDFEDSPYFKENSA------F 170
Query: 542 PVGCCKLKEKYQYDPNKKFEYNDAKKNFENDNCPFDNDKSTININGCIPSLIDLIEKN 715
P CC ND N N+ C + GC L+ I N
Sbjct: 171 PPFCC----------------NDNVTNTANETCTKQKAHDQ-KVEGCFNQLLYDIRTN 211
>sp|Q58CY8|TSN18_BOVIN Tetraspanin-18 (Tspan-18)
Length = 249
Score = 62.8 bits (151), Expect = 1e-09
Identities = 58/265 (21%), Positives = 99/265 (37%), Gaps = 1/265 (0%)
Frame = +2
Query: 5 IFNILFFLIGAVILGVGIWVKVDKSNLFEVIRNIKLDDTTASFNNTNSTILDVVAIVLII 184
+FN FL GA +LG+GIWV VD + E++ + +L A +L+
Sbjct: 15 VFNFFIFLGGACLLGIGIWVMVDPTGFREIV--------------AANPLLITGAYILLA 60
Query: 185 XXXXXXXXXXXXXXXAIKENKCLLITYSILXXXXXXXXXXXXXXXXXEKNKFQKNLGKS- 361
A++ENKCLL+ + + F+ NL +
Sbjct: 61 MGGLLFLLGFLGCCGAVRENKCLLLFFFLFILIIFLAELSAAILAFI----FRGNLTREF 116
Query: 362 LTNVLEKDFNGILNTNATLFTKIFTAIMFELKCCGVNNVTDFDSVRNWKSTSSSGTKQIY 541
T L K + G +T+ +F+ + ++M CCGVN DF ++ + +
Sbjct: 117 FTKELTKHYQGSNDTD--VFSATWNSVMITFGCCGVNGPEDFKYASVFRLLTLDSDE--V 172
Query: 542 PVGCCKLKEKYQYDPNKKFEYNDAKKNFENDNCPFDNDKSTININGCIPSLIDLIEKNMX 721
P CC+ +E D + C D +N GC +++ E +
Sbjct: 173 PEACCR-REPQSRD----------GVLLSREECLLGRD-LFLNKQGCYTVILNAFETYVY 220
Query: 722 XXXXXXXXXXXFEIMCIVFACCVMR 796
E+ ++FA C+ R
Sbjct: 221 LAGALAIGVLAIELFAMIFAMCLFR 245
>sp|Q5RC27|TSN1_PONPY Tetraspanin-1 (Tspan-1)
Length = 241
Score = 61.6 bits (148), Expect = 3e-09
Identities = 55/238 (23%), Positives = 87/238 (36%)
Frame = +2
Query: 2 IIFNILFFLIGAVILGVGIWVKVDKSNLFEVIRNIKLDDTTASFNNTNSTILDVVAIVLI 181
I+FN+L FL GA +L VGIWV +D ++ ++ L + F N ++ +V
Sbjct: 12 ILFNLLIFLCGAALLAVGIWVSIDGASFLKIFG--PLSSSAMQFVNVGYFLIAAGVVVFA 69
Query: 182 IXXXXXXXXXXXXXXXAIKENKCLLITYSILXXXXXXXXXXXXXXXXXEKNKFQKNLGKS 361
+ A E+KC L+T+ + + L
Sbjct: 70 L--------GFLGCYGAKTESKCALMTFFFILLLIFIAEVAAAVVALVYTTMAEHFLTLL 121
Query: 362 LTNVLEKDFNGILNTNATLFTKIFTAIMFELKCCGVNNVTDFDSVRNWKSTSSSGTKQIY 541
+ ++KD+ + FT+++ M LKCCG N TDF+ K + +
Sbjct: 122 VVPAIKKDYG-----SQEDFTQVWNTTMKGLKCCGFTNYTDFEDSPYLKENHA------F 170
Query: 542 PVGCCKLKEKYQYDPNKKFEYNDAKKNFENDNCPFDNDKSTININGCIPSLIDLIEKN 715
P CC ND N ND C + + GC L+ I N
Sbjct: 171 PPFCC----------------NDNITNTANDTCTKQKAEDQ-KVEGCFNQLLYDIRTN 211
>sp|Q96SJ8|TSN18_HUMAN Tetraspanin-18 (Tspan-18)
Length = 248
Score = 60.5 bits (145), Expect = 6e-09
Identities = 56/265 (21%), Positives = 97/265 (36%), Gaps = 1/265 (0%)
Frame = +2
Query: 5 IFNILFFLIGAVILGVGIWVKVDKSNLFEVIRNIKLDDTTASFNNTNSTILDVVAIVLII 184
+FN FL GA +L +GIWV VD + E++ + +L A +L+
Sbjct: 15 VFNFFIFLGGACLLAIGIWVMVDPTGFREIV--------------AANPLLLTGAYILLA 60
Query: 185 XXXXXXXXXXXXXXXAIKENKCLLITYSILXXXXXXXXXXXXXXXXXEKNKFQKNLGKS- 361
A++ENKCLL+ + + F++NL +
Sbjct: 61 MGGLLFLLGFLGCCGAVRENKCLLLFFFLFILIIFLAELSAAILAFI----FRENLTREF 116
Query: 362 LTNVLEKDFNGILNTNATLFTKIFTAIMFELKCCGVNNVTDFDSVRNWKSTSSSGTKQIY 541
T L K + G N + +F+ + ++M CCGVN DF ++ + +
Sbjct: 117 FTKELTKHYQG--NNDTDVFSATWNSVMITFGCCGVNGPEDFKFASVFRLLTLDSEE--V 172
Query: 542 PVGCCKLKEKYQYDPNKKFEYNDAKKNFENDNCPFDNDKSTININGCIPSLIDLIEKNMX 721
P CC+ +E D + C +N GC +++ E +
Sbjct: 173 PEACCR-REPQSRD----------GVLLSREECLLGR-SLFLNKQGCYTVILNTFETYVY 220
Query: 722 XXXXXXXXXXXFEIMCIVFACCVMR 796
E+ ++FA C+ R
Sbjct: 221 LAGALAIGVLAIELFAMIFAMCLFR 245
>sp|P27701|CD82_HUMAN CD82 antigen (Inducible membrane protein R2) (C33 antigen) (IA4)
(Metastasis suppressor Kangai 1) (Suppressor of
tumorigenicity-6) (Tetraspanin-27) (Tspan-27)
Length = 267
Score = 58.9 bits (141), Expect = 2e-08
Identities = 55/266 (20%), Positives = 108/266 (40%), Gaps = 2/266 (0%)
Frame = +2
Query: 5 IFNILFFLIGAVILGVGIWVKVDKSNLFEVIRNIKLDDTTASFNNTNSTILDVVAIVLII 184
+FN++FF++GAVILG G+W+ DKS+ V++ T+S+ L + A V I
Sbjct: 15 LFNLIFFILGAVILGFGVWILADKSSFISVLQ-------------TSSSSLRMGAYVFIG 61
Query: 185 XXXXXXXXXXXXXXXAIKENKCLLITYSILXXXXXXXXXXXXXXXXXEKNKFQKNLGKSL 364
A+ E +CLL Y K ++ +G +
Sbjct: 62 VGAVTMLMGFLGCIGAVNEVRCLLGLYFAFLLLILIAQVTAGALFYFNMGKLKQEMGGIV 121
Query: 365 TNVLEKDFNGILNTNATLFTKIFTAIMFELKCCGVNNVTDFDSVRNWKSTSSSGTKQIYP 544
T ++ +D+N ++ + + ++KCCG + S NW + +
Sbjct: 122 TELI-RDYN---SSREDSLQDAWDYVQAQVKCCG------WVSFYNWTDNAELMNRPEVT 171
Query: 545 VGC-CKLKEKYQYDPNKKFEYNDAKKN-FENDNCPFDNDKSTININGCIPSLIDLIEKNM 718
C C++K + + + + +A N ++ N P D + GC+ + +++N+
Sbjct: 172 YPCSCEVKGEEDNSLSVRKGFCEAPGNRTQSGNHPED---WPVYQEGCMEKVQAWLQENL 228
Query: 719 XXXXXXXXXXXXFEIMCIVFACCVMR 796
E++ +V + C+ R
Sbjct: 229 GIILGVGVGVAIIELLGMVLSICLCR 254
>sp|O75954|TSN9_HUMAN Tetraspanin-9 (Tspan-9) (Tetraspan NET-5)
Length = 239
Score = 58.5 bits (140), Expect = 2e-08
Identities = 56/210 (26%), Positives = 88/210 (41%), Gaps = 14/210 (6%)
Frame = +2
Query: 5 IFNILFFLIGAVILGVGIWVKVDKSNLFEVIRNIKLDDTTASFNNTNSTILDVVAIVLII 184
+FN++F+L G +LGVGIW+ V + N + SF + ++ L V+AI I+
Sbjct: 15 LFNLIFWLCGCGLLGVGIWLSVSQGNFATF---------SPSFPSLSAANL-VIAIGTIV 64
Query: 185 XXXXXXXXXXXXXXXAIKENKCLLITYSILXXXXXXXXXXXXXXXXXEKNKFQKNLGKSL 364
AIKENKCLL+++ I+ +K +N K L
Sbjct: 65 -----MVTGFLGCLGAIKENKCLLLSFFIVLLVILLAELILLILFFVYMDKVNENAKKDL 119
Query: 365 TN--VLEKDFNGILNTNATLFTKIFTAIMFELKCCGVNNVTDFDSV------------RN 502
+L N + NA + I E++CCGV + TD+ V N
Sbjct: 120 KEGLLLYHTENNVGLKNA------WNIIQAEMRCCGVTDYTDWYPVLGENTVPDRCCMEN 173
Query: 503 WKSTSSSGTKQIYPVGCCKLKEKYQYDPNK 592
+ + T ++ GC + K K +D NK
Sbjct: 174 SQGCGRNATTPLWRTGCYE-KVKMWFDDNK 202
>sp|Q8BJU2|TSN9_MOUSE Tetraspanin-9 (Tspan-9) (Tetraspan NET-5)
Length = 239
Score = 57.8 bits (138), Expect = 4e-08
Identities = 55/209 (26%), Positives = 89/209 (42%), Gaps = 13/209 (6%)
Frame = +2
Query: 5 IFNILFFLIGAVILGVGIWVKVDKSNLFEVIRNIKLDDTTASFNNTNSTILDVVAIVLII 184
+FN++F+L G +LGVGIW+ V + N + SF + ++ L V+AI I+
Sbjct: 15 LFNLIFWLCGCGLLGVGIWLSVSQGNFATF---------SPSFPSLSAANL-VIAIGTIV 64
Query: 185 XXXXXXXXXXXXXXXAIKENKCLLITYSILXXXXXXXXXXXXXXXXXEKNKFQKNLGKSL 364
AIKENKCLL+++ I+ +K +N + L
Sbjct: 65 -----MVTGFLGCLGAIKENKCLLLSFFIVLLIILLAELILIILFFVYMDKVNENAKQDL 119
Query: 365 TNVLEKDFNGILNTNATLFTK-IFTAIMFELKCCGVNNVTDFDSV------------RNW 505
K+ + NT + K + I E++CCGV + TD+ V N
Sbjct: 120 -----KEGLLLYNTENNVGLKNAWNIIQAEMRCCGVTDYTDWYPVLGENTVPDRCCMENS 174
Query: 506 KSTSSSGTKQIYPVGCCKLKEKYQYDPNK 592
+ + T ++ GC + K K +D NK
Sbjct: 175 QGCGRNSTTPLWRTGCYE-KVKLWFDDNK 202
Database: Non-redundant SwissProt sequences
Posted date: Dec 6, 2005 7:40 AM
Number of letters in database: 68,354,980
Number of sequences in database: 184,735
Database: swissprot.01
Posted date: Dec 6, 2005 8:18 AM
Number of letters in database: 66,202,850
Number of sequences in database: 184,431
Lambda K H
0.318 0.134 0.401
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 89,560,690
Number of Sequences: 369166
Number of extensions: 1735834
Number of successful extensions: 4708
Number of sequences better than 10.0: 10
Number of HSP's better than 10.0 without gapping: 4502
Number of HSP's successfully gapped in prelim test: 0
Number of HSP's that attempted gapping in prelim test: 0
Number of HSP's gapped (non-prelim): 4664
length of database: 68,354,980
effective HSP length: 109
effective length of database: 48,218,865
effective search space used: 8341863645
frameshift window, decay const: 40, 0.1
T: 12
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)