Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= Dr_sW_006_L22
(884 letters)
Database: Non-redundant SwissProt sequences
184,735 sequences; 68,354,980 total letters
Score E
Sequences producing significant alignments: (bits) Value
sp|Q9BYM8|UB7I3_HUMAN Ubiquitin-conjugating enzyme 7-intera... 151 3e-36
sp|Q9WUB0|UB7I3_MOUSE Ubiquitin-conjugating enzyme 7-intera... 150 3e-36
sp|Q62921|UB7I3_RAT Ubiquitin-conjugating enzyme 7-interact... 148 2e-35
sp|Q6ZMZ0|IBR3_HUMAN IBR domain containing protein 3 51 5e-06
sp|O76924|ARI2_DROME Ariadne-2 protein (Ari-2) 49 2e-05
sp|Q9NWF9|UB7I1_HUMAN E3 ubiquitin ligase TRIAD3 (Ubiquitin... 47 9e-05
sp|P36113|YKZ7_YEAST Hypothetical 63.6 kDa protein in YPT52... 46 2e-04
sp|P58283|UB7I1_MOUSE E3 ubiquitin ligase TRIAD3 (Ubiquitin... 45 3e-04
sp|Q9JI90|RNF14_MOUSE RING finger protein 14 (Androgen rece... 45 3e-04
sp|Q9UBS8|RNF14_HUMAN RING finger protein 14 (Androgen rece... 45 4e-04
>sp|Q9BYM8|UB7I3_HUMAN Ubiquitin-conjugating enzyme 7-interacting protein 3 (Hepatitis B
virus X-associated protein 4) (HBV-associated factor 4)
(RING finger protein 54)
Length = 500
Score = 151 bits (381), Expect = 3e-36
Identities = 73/226 (32%), Positives = 115/226 (50%), Gaps = 15/226 (6%)
Frame = +2
Query: 14 CNLCCLVICKGEGVKLQNCGDLICKSCLLNSIETTTKIPAQCP------SCQQSINDREI 175
C +C V+ GE V L+ C C+ CL +I + + CP SC + +REI
Sbjct: 272 CPVCYSVLAPGEAVVLRECLHTFCRECLQGTIRNSQEAEVSCPFIDNTYSCSGKLLEREI 331
Query: 176 RAILSDHQFSIY-QVKCQGFSKKSIPHFQCQTPNCDAFYEISESLKEFTXXXXXXXXXXX 352
+A+L+ + + + +S + C+TP+C + + + EFT
Sbjct: 332 KALLTPEDYQRFLDLGISIAENRSAFSYHCKTPDCKGWCFFEDDVNEFTCPVCFHVNCLL 391
Query: 353 XXTVHLNENCEQFKK----RMETDVNMKAIEEKIK----NKELMKCPKCGNLLMKISGCN 508
+H NC+++++ R + DV + E +K E M+CP+C ++ K GC+
Sbjct: 392 CKAIHEQMNCKEYQEDLALRAQNDVAARQTTEMLKVMLQQGEAMRCPQCQIVVQKKDGCD 451
Query: 509 WIQCTNCLTELCWIRQMERWGPGGRDDISGGCRCMVGGVPCDPLCK 646
WI+CT C TE+CW+ + RWGPGG D SGGCRC V G+PC P C+
Sbjct: 452 WIRCTVCHTEICWVTKGPRWGPGGPGDTSGGCRCRVNGIPCHPSCQ 497
>sp|Q9WUB0|UB7I3_MOUSE Ubiquitin-conjugating enzyme 7-interacting protein 3
(UbcM4-interacting protein 28)
Length = 498
Score = 150 bits (380), Expect = 3e-36
Identities = 75/226 (33%), Positives = 113/226 (50%), Gaps = 15/226 (6%)
Frame = +2
Query: 14 CNLCCLVICKGEGVKLQNCGDLICKSCLLNSIETTTKIPAQCP------SCQQSINDREI 175
C +C V+ GE V L+ C C+ CL +I + + CP SC + +REI
Sbjct: 270 CPVCYSVLAPGEAVVLRECLHTFCRECLQGTIRNSQEAEVACPFIDSTYSCPGKLLEREI 329
Query: 176 RAILSDHQFSIY-QVKCQGFSKKSIPHFQCQTPNCDAFYEISESLKEFTXXXXXXXXXXX 352
RA+LS + + + +S + C+TP+C + + + EFT
Sbjct: 330 RALLSPEDYQRFLDLGVSIAENRSTLSYHCKTPDCRGWCFFEDDVNEFTCPVCTRVNCLL 389
Query: 353 XXTVHLNENCEQFKK----RMETDVNMKAIEEKIK----NKELMKCPKCGNLLMKISGCN 508
+H + NC +++ R + DV + E +K E M CP+C ++ K GC+
Sbjct: 390 CKAIHEHMNCREYQDDLALRAQNDVAARQTTEMLKVMLQQGEAMHCPQCRIVVQKKDGCD 449
Query: 509 WIQCTNCLTELCWIRQMERWGPGGRDDISGGCRCMVGGVPCDPLCK 646
WI+CT C TE+CW+ + RWGPGG D SGGCRC V G+PC P C+
Sbjct: 450 WIRCTVCHTEICWVTKGPRWGPGGPGDTSGGCRCRVNGIPCHPSCQ 495
>sp|Q62921|UB7I3_RAT Ubiquitin-conjugating enzyme 7-interacting protein 3 (RBCC protein
interacting with PKC) (Protein kinase C-binding protein
beta-15)
Length = 498
Score = 148 bits (373), Expect = 2e-35
Identities = 74/226 (32%), Positives = 111/226 (49%), Gaps = 15/226 (6%)
Frame = +2
Query: 14 CNLCCLVICKGEGVKLQNCGDLICKSCLLNSIETTTKIPAQCP------SCQQSINDREI 175
C +C V+ GE V L+ C C+ CL +I + + CP SC + +REI
Sbjct: 270 CPVCYSVLAPGEAVVLRECLHTFCRECLQGTIRNSQEAEVSCPFIDNTYSCPGKLLEREI 329
Query: 176 RAILSDHQFSIY-QVKCQGFSKKSIPHFQCQTPNCDAFYEISESLKEFTXXXXXXXXXXX 352
RA+LS + + + +S + C+TP+C + + + EFT
Sbjct: 330 RALLSPEDYQRFLDLGVSIAENRSTLSYHCKTPDCRGWCFFEDDVNEFTCPVCTRVNCLL 389
Query: 353 XXTVHLNENCEQFKK----RMETDVNMKAIEEKIK----NKELMKCPKCGNLLMKISGCN 508
+H NC +++ R DV + E ++ E M CP+C ++ K GC+
Sbjct: 390 CKAIHERMNCREYQDDLAHRARNDVAAQQTTEMLRVMLQQGEAMYCPQCRIVVQKKDGCD 449
Query: 509 WIQCTNCLTELCWIRQMERWGPGGRDDISGGCRCMVGGVPCDPLCK 646
WI+CT C TE+CW+ + RWGPGG D SGGCRC V G+PC P C+
Sbjct: 450 WIRCTVCHTEICWVTKGPRWGPGGPGDTSGGCRCRVNGIPCHPSCQ 495
>sp|Q6ZMZ0|IBR3_HUMAN IBR domain containing protein 3
Length = 486
Score = 50.8 bits (120), Expect = 5e-06
Identities = 38/209 (18%), Positives = 81/209 (38%), Gaps = 36/209 (17%)
Frame = +2
Query: 44 GEGVKLQNCGDLICKSCLLNSIE---TTTKIPAQCPSCQQSINDREIRAILSD----HQF 202
G +L +C C+ CL + + + +++P CP C + +N +IR +L+D H++
Sbjct: 28 GRRRRLLSCPHRSCRDCLRHYLRLEISESRVPISCPECSERLNPHDIRLLLADPPLMHKY 87
Query: 203 SIYQVK--------CQ------------GFSKKSIPHFQCQTPNCDAFYEISESLKEFTX 322
+ ++ C+ + S P C+ C E K+
Sbjct: 88 EEFMLRRYLASDPDCRWCPAPDCGYAVIAYGCASCPKLTCEREGCQT--EFCYHCKQIW- 144
Query: 323 XXXXXXXXXXXXTVHLNENCEQFKKRMETDVNMK-------AIEEKIKNKELMKCPKCGN 481
H N+ C+ +++ + ++ + ++ ++ CP+C
Sbjct: 145 --------------HPNQTCDMARQQRAQTLRVRTKHTSGLSYGQESGPDDIKPCPRCSA 190
Query: 482 LLMKIS--GCNWIQCTNCLTELCWIRQME 562
++K++ CN + C C E CW+ E
Sbjct: 191 YIIKMNDGSCNHMTCAVCGCEFCWLCMKE 219
>sp|O76924|ARI2_DROME Ariadne-2 protein (Ari-2)
Length = 509
Score = 48.9 bits (115), Expect = 2e-05
Identities = 41/174 (23%), Positives = 65/174 (37%), Gaps = 13/174 (7%)
Frame = +2
Query: 68 CGDLICKSCLLNSIET------TTKIPAQCPSCQQSINDREIRAILSDHQFSIYQVKCQG 229
CG CK C ET +T+I C + + + +++ + + K Q
Sbjct: 170 CGHSFCKDCWTIYFETQIFQGISTQIGCMAQMCNVRVPEDLVLTLVTR---PVMRDKYQQ 226
Query: 230 FS----KKSIPHFQ-CQTPNCDAFYEISE--SLKEFTXXXXXXXXXXXXXTVHLNENCEQ 388
F+ KS P + C PNC + SE + + H +C+
Sbjct: 227 FAFKDYVKSHPELRFCPGPNCQIIVQSSEISAKRAICKACHTGFCFRCGMDYHAPTDCQV 286
Query: 389 FKKRMETDVNMKAIEEKIKNKELMKCPKCGNLLMKISGCNWIQCTNCLTELCWI 550
KK + + I + CPKC + K GCN +QC NC + CW+
Sbjct: 287 IKKWLTKCADDSETANYI-SAHTKDCPKCHICIEKNGGCNHMQCFNCKHDFCWM 339
>sp|Q9NWF9|UB7I1_HUMAN E3 ubiquitin ligase TRIAD3 (Ubiquitin conjugating enzyme 7
interacting protein 1) (Zinc finger protein inhibiting
NF-kappa-B)
Length = 866
Score = 46.6 bits (109), Expect = 9e-05
Identities = 42/180 (23%), Positives = 71/180 (39%), Gaps = 15/180 (8%)
Frame = +2
Query: 56 KLQNCGD--LICKSCLLNSIETTT----KIPAQCP--SCQQSINDREIRAILSDH-QFSI 208
+L C D L CK CL+ + K+ C SC S E+ +L +
Sbjct: 526 ELTQCADAHLFCKECLIRYAQEAVFGSGKLELSCMEGSCTCSFPTSELEKVLPQTILYKY 585
Query: 209 YQVKCQGFSKKSIPHFQCQTPNCDAFYEISESLKEFTXXXXXXXXXXXXXTV-----HLN 373
Y+ K + + + P+C + +K F+ H
Sbjct: 586 YERKAEEEVAAAYADELVRCPSCSFPALLDSDVKRFSCPNPHCRKETCRKCQGLWKEHNG 645
Query: 374 ENCEQFKKRMETDVNMK-AIEEKIKNKELMKCPKCGNLLMKISGCNWIQCTNCLTELCWI 550
CE+ ++ D+ + +IEEK+ + KC KCG L+K GCN + C C ++C++
Sbjct: 646 LTCEELAEK--DDIKYRTSIEEKMTAARIRKCHKCGTGLIKSEGCNRMSC-RCGAQMCYL 702
>sp|P36113|YKZ7_YEAST Hypothetical 63.6 kDa protein in YPT52-GCN3 intergenic region
Length = 551
Score = 45.8 bits (107), Expect = 2e-04
Identities = 49/211 (23%), Positives = 80/211 (37%), Gaps = 18/211 (8%)
Frame = +2
Query: 8 FTCNLCCLVICKGEGVKLQNCGDLICKSCLLNSIETTTKIP--AQCPSCQQSINDREIRA 181
FTC +CC K CG C +C + I+ C C ++ + +I
Sbjct: 177 FTCIICCDK--KDTETFALECGHEYCINCYRHYIKDKLHEGNIITCMDCSLALKNEDIDK 234
Query: 182 ILSDHQFS-IYQVKCQGFSKKSIPHFQ-CQTPNCDAFYEISE--SLKEFTXXXXXXXXXX 349
++ S + + F +K +++ C +C + + + SL E+T
Sbjct: 235 VMGHPSSSKLMDSSIKSFVQKHNRNYKWCPFADCKSIVHLRDTSSLPEYTRLHYSPFVKC 294
Query: 350 XXX---------TVHLNENCEQFKKRMETDVNMKAIEEKIKNKELM---KCPKCGNLLMK 493
VH +C K V E +I N L +CPKC + K
Sbjct: 295 NSFHRFCFNCGFEVHSPADC----KITTAWVKKARKESEILNWVLSHTKECPKCSVNIEK 350
Query: 494 ISGCNWIQCTNCLTELCWIRQMERWGPGGRD 586
GCN + C++C E CWI + W P G++
Sbjct: 351 NGGCNHMVCSSCKYEFCWICE-GPWAPHGKN 380
>sp|P58283|UB7I1_MOUSE E3 ubiquitin ligase TRIAD3 (Ubiquitin-conjugating enzyme
7-interacting protein 1) (UbcM4-interacting protein 83)
Length = 853
Score = 45.1 bits (105), Expect = 3e-04
Identities = 42/180 (23%), Positives = 70/180 (38%), Gaps = 15/180 (8%)
Frame = +2
Query: 56 KLQNCGD--LICKSCLLNSIETTT----KIPAQCP--SCQQSINDREIRAILSDH-QFSI 208
+L C D L CK CL+ + K C SC S E+ +L +
Sbjct: 514 ELTQCADAHLFCKECLIRYAQEAVFGSGKSELSCMEGSCTCSFPTSELEKVLPQTILYKY 573
Query: 209 YQVKCQGFSKKSIPHFQCQTPNCDAFYEISESLKEFTXXXXXXXXXXXXXTV-----HLN 373
Y+ K + + + P+C + +K F+ H
Sbjct: 574 YERKAEEEVAAAYADELVRCPSCSFPALLDSDVKRFSCPNPRCRKETCRKCQGLWKEHNG 633
Query: 374 ENCEQFKKRMETDVNMK-AIEEKIKNKELMKCPKCGNLLMKISGCNWIQCTNCLTELCWI 550
CE+ ++ D+ + +IEEK+ + KC KCG L+K GCN + C C ++C++
Sbjct: 634 LTCEELAEK--DDIKYRTSIEEKMTAARIRKCHKCGTGLIKSEGCNRMSC-RCGAQMCYL 690
>sp|Q9JI90|RNF14_MOUSE RING finger protein 14 (Androgen receptor-associated protein 54)
(Triad2 protein)
Length = 485
Score = 45.1 bits (105), Expect = 3e-04
Identities = 22/57 (38%), Positives = 29/57 (50%), Gaps = 4/57 (7%)
Frame = +2
Query: 392 KKRMETDVNMKAIEEKIKNKELMK----CPKCGNLLMKISGCNWIQCTNCLTELCWI 550
++R V KA+EE L K CP CG + K+ GCN + CT C+ CWI
Sbjct: 377 EQRYGKRVIQKALEEMESKDWLEKNSKSCPCCGTPIQKLDGCNKMTCTGCMQYFCWI 433
>sp|Q9UBS8|RNF14_HUMAN RING finger protein 14 (Androgen receptor-associated protein 54)
(Triad2 protein) (HFB30)
Length = 474
Score = 44.7 bits (104), Expect = 4e-04
Identities = 21/50 (42%), Positives = 27/50 (54%), Gaps = 4/50 (8%)
Frame = +2
Query: 413 VNMKAIEEKIKNKELMK----CPKCGNLLMKISGCNWIQCTNCLTELCWI 550
V KA+EE + L K CP CG + K+ GCN + CT C+ CWI
Sbjct: 383 VIQKALEEMESKEWLEKNSKSCPCCGTPIEKLDGCNKMTCTGCMQYFCWI 432
Database: Non-redundant SwissProt sequences
Posted date: Dec 6, 2005 7:40 AM
Number of letters in database: 68,354,980
Number of sequences in database: 184,735
Database: swissprot.01
Posted date: Dec 6, 2005 8:18 AM
Number of letters in database: 66,202,850
Number of sequences in database: 184,431
Lambda K H
0.318 0.134 0.401
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 99,925,597
Number of Sequences: 369166
Number of extensions: 2076158
Number of successful extensions: 6846
Number of sequences better than 10.0: 10
Number of HSP's better than 10.0 without gapping: 6302
Number of HSP's successfully gapped in prelim test: 0
Number of HSP's that attempted gapping in prelim test: 0
Number of HSP's gapped (non-prelim): 6816
length of database: 68,354,980
effective HSP length: 110
effective length of database: 48,034,130
effective search space used: 8838279920
frameshift window, decay const: 40, 0.1
T: 12
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)