Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= Dr_sW_006_K06
(695 letters)
Database: Non-redundant SwissProt sequences
184,735 sequences; 68,354,980 total letters
Score E
Sequences producing significant alignments: (bits) Value
sp|P70196|TRAF6_MOUSE TNF receptor-associated factor 6 52 1e-06
sp|Q9Y4K3|TRAF6_HUMAN TNF receptor-associated factor 6 (Int... 51 3e-06
sp|Q8N448|LNX2_HUMAN Ligand of Numb-protein X 2 (Numb-bindi... 51 3e-06
sp|Q91XL2|LNX2_MOUSE Ligand of Numb-protein X 2 (Numb-bindi... 49 1e-05
sp|Q8TBB1|LNX1_HUMAN Ubiquitin ligase LNX (Numb-binding pro... 49 1e-05
sp|O70263|LNX1_MOUSE Ubiquitin ligase LNX (Numb-binding pro... 49 1e-05
sp|P68907|PZRN3_RAT PDZ domain-containing RING finger prote... 43 0.001
sp|Q61382|TRAF4_MOUSE TNF receptor-associated factor 4 (Cys... 42 0.002
sp|Q69ZS0|PZRN3_MOUSE PDZ domain-containing RING finger pro... 42 0.002
sp|Q9UPQ7|PZRN3_HUMAN PDZ domain-containing RING finger pro... 41 0.003
>sp|P70196|TRAF6_MOUSE TNF receptor-associated factor 6
Length = 530
Score = 52.4 bits (124), Expect = 1e-06
Identities = 32/127 (25%), Positives = 53/127 (41%), Gaps = 4/127 (3%)
Frame = +2
Query: 242 INNDFVCNICNKLMVKACNAPCGCKYCSECIENYLHGKDKFCPGKDKFRQMKMINFEKDV 421
+ + + C IC + +A PCG ++C CI + CP ++ I E +
Sbjct: 64 LESKYECPICLMALREAVQTPCGHRFCKACIIKSIRDAGHKCPVDNE------ILLENQL 117
Query: 422 SINHQTNRRIAEIVVKCSNKNCKFTDELSSMGNHARTCNKNPTSCPY----FEMGCKNDE 589
++ R I + VKC NK C EL + +H C +CP F+ N
Sbjct: 118 FPDNFAKREILSLTVKCPNKGCLQKMELRHLEDHQVHCEFALVNCPQCQRPFQKCQVNTH 177
Query: 590 VMNDDPK 610
++ D P+
Sbjct: 178 IIEDCPR 184
>sp|Q9Y4K3|TRAF6_HUMAN TNF receptor-associated factor 6 (Interleukin 1 signal transducer)
(RING finger protein 85)
Length = 522
Score = 51.2 bits (121), Expect = 3e-06
Identities = 31/127 (24%), Positives = 53/127 (41%), Gaps = 4/127 (3%)
Frame = +2
Query: 242 INNDFVCNICNKLMVKACNAPCGCKYCSECIENYLHGKDKFCPGKDKFRQMKMINFEKDV 421
+ + + C IC + +A PCG ++C CI + CP ++ I E +
Sbjct: 64 LESKYECPICLMALREAVQTPCGHRFCKACIIKSIRDAGHKCPVDNE------ILLENQL 117
Query: 422 SINHQTNRRIAEIVVKCSNKNCKFTDELSSMGNHARTCNKNPTSCPY----FEMGCKNDE 589
++ R I ++VKC N+ C EL + +H C CP F+ N
Sbjct: 118 FPDNFAKREILSLMVKCPNEGCLHKMELRHLEDHQAHCEFALMDCPQCQRPFQKFHINIH 177
Query: 590 VMNDDPK 610
++ D P+
Sbjct: 178 ILKDCPR 184
>sp|Q8N448|LNX2_HUMAN Ligand of Numb-protein X 2 (Numb-binding protein 2) (PDZ
domain-containing RING finger protein 1)
Length = 690
Score = 51.2 bits (121), Expect = 3e-06
Identities = 22/54 (40%), Positives = 36/54 (66%), Gaps = 1/54 (1%)
Frame = +2
Query: 212 RENK-FQLINEINNDFVCNICNKLMVKACNAPCGCKYCSECIENYLHGKDKFCP 370
REN + NE+++D VC+IC + +++ + PCG +C +C+ N+L KD FCP
Sbjct: 33 RENHLYNYQNEVDDDLVCHICLQPLLQPLDTPCGHTFCYKCLRNFLQEKD-FCP 85
>sp|Q91XL2|LNX2_MOUSE Ligand of Numb-protein X 2 (Numb-binding protein 2)
Length = 687
Score = 49.3 bits (116), Expect = 1e-05
Identities = 21/54 (38%), Positives = 35/54 (64%), Gaps = 1/54 (1%)
Frame = +2
Query: 212 RENK-FQLINEINNDFVCNICNKLMVKACNAPCGCKYCSECIENYLHGKDKFCP 370
REN + E+++D VC+IC + +++ + PCG +C +C+ N+L KD FCP
Sbjct: 34 RENHLYNYQGEVDDDLVCHICLQPLLQPLDTPCGHTFCHKCLRNFLQEKD-FCP 86
>sp|Q8TBB1|LNX1_HUMAN Ubiquitin ligase LNX (Numb-binding protein 1) (Ligand of
Numb-protein X 1)
Length = 728
Score = 48.9 bits (115), Expect = 1e-05
Identities = 32/113 (28%), Positives = 59/113 (52%), Gaps = 2/113 (1%)
Frame = +2
Query: 209 IRENKFQLI-NEINNDFVCNICNKLMVKACNAPCGCKYCSECIENYLHGKDKFCPGKDKF 385
+ EN F E+++D +C+IC + ++ + PCG YC+ C+ N+L KD FCP
Sbjct: 23 LEENHFYSYPEEVDDDLICHICLQALLDPLDTPCGHTYCTLCLTNFLVEKD-FCP---MD 78
Query: 386 RQMKMINFEKDVSINHQTNRRIAEIVVKCS-NKNCKFTDELSSMGNHARTCNK 541
R+ ++ K SI N+ + +++V C ++C + + +H +T K
Sbjct: 79 RKPLVLQHCKKSSI--LVNKLLNKLLVTCPFREHCTQVLQRCDLEHHFQTSCK 129
>sp|O70263|LNX1_MOUSE Ubiquitin ligase LNX (Numb-binding protein 1) (Ligand of
Numb-binding protein 1) (Ligand of Numb-protein X 1)
Length = 728
Score = 48.9 bits (115), Expect = 1e-05
Identities = 35/118 (29%), Positives = 53/118 (44%), Gaps = 4/118 (3%)
Frame = +2
Query: 215 ENKFQLINE-INNDFVCNICNKLMVKACNAPCGCKYCSECIENYLHGKDKFCPGKDKFRQ 391
EN F E +++D +C+IC + ++ + PCG YC+ C+ N+L KD FCP
Sbjct: 29 ENHFYTYTEDVDDDLICHICLQALLDPLDTPCGHTYCTLCLTNFLVEKD-FCPVD----- 82
Query: 392 MKMINFEKDVSINHQTNRRIAEIVVKCSNK---NCKFTDELSSMGNHARTCNKNPTSC 556
K V + H I +V K NK C FT+ + + + TSC
Sbjct: 83 ------RKPVVLQHCKKSSI--LVNKLLNKLLVTCPFTEHCTEVLQRCDLQHHFQTSC 132
>sp|P68907|PZRN3_RAT PDZ domain-containing RING finger protein 3 (Semaphorin cytoplasmic
domain-associated protein 3) (SEMACAP3 protein)
Length = 1062
Score = 42.7 bits (99), Expect = 0.001
Identities = 25/114 (21%), Positives = 53/114 (46%), Gaps = 2/114 (1%)
Frame = +2
Query: 239 EINNDFVCNICNKLMVKACNAPCGCKYCSECIENYLHGKDKFCPGKDKFRQMKMINFEKD 418
E++ D C +C+K++ PCG +C+ C+ ++ ++ CP + + R K+
Sbjct: 11 EVDPDLKCALCHKVLEDPLTTPCGHVFCAGCVLPWV-VQEGSCPSRCRGRLS-----AKE 64
Query: 419 VSINHQTNRRIAEIVVKCSN--KNCKFTDELSSMGNHARTCNKNPTSCPYFEMG 574
++ R I ++ +KC++ + C +L + H C+ P C + G
Sbjct: 65 LNHVLPLKRLILKLDIKCAHAARGCGRVVKLQDLPEHLERCDFAPARCRHAGCG 118
>sp|Q61382|TRAF4_MOUSE TNF receptor-associated factor 4 (Cysteine-rich motif associated to
RING and Traf domains protein 1)
Length = 470
Score = 41.6 bits (96), Expect = 0.002
Identities = 23/104 (22%), Positives = 46/104 (44%), Gaps = 3/104 (2%)
Frame = +2
Query: 257 VCNICNKLMVKACN-APCGCKYCSECIENYLHGKDKFCPGKDKFRQMKMINFEKDVSINH 433
+C +C K M + + CG +YC C++ +L CP I + ++ +
Sbjct: 17 LCPLCGKPMRDSVEVSTCGHRYCDNCLQEFLSEGVFKCPEDQLPLDYAKIYPDPELEV-- 74
Query: 434 QTNRRIAEIVVKC--SNKNCKFTDELSSMGNHARTCNKNPTSCP 559
++ + ++C S + C+++ L + H TC+ N CP
Sbjct: 75 ----QVLGLAIRCIHSEEGCRWSGPLRHLQGHLNTCSFNVVPCP 114
>sp|Q69ZS0|PZRN3_MOUSE PDZ domain-containing RING finger protein 3 (Semaphorin cytoplasmic
domain-associated protein 3) (SEMACAP3 protein)
Length = 1063
Score = 41.6 bits (96), Expect = 0.002
Identities = 24/114 (21%), Positives = 53/114 (46%), Gaps = 2/114 (1%)
Frame = +2
Query: 239 EINNDFVCNICNKLMVKACNAPCGCKYCSECIENYLHGKDKFCPGKDKFRQMKMINFEKD 418
+++ D C +C+K++ PCG +C+ C+ ++ ++ CP + + R K+
Sbjct: 11 DVDPDLKCALCHKVLEDPLTTPCGHVFCAGCVLPWV-VQEGSCPARCRGRLS-----AKE 64
Query: 419 VSINHQTNRRIAEIVVKCSN--KNCKFTDELSSMGNHARTCNKNPTSCPYFEMG 574
++ R I ++ +KC++ + C +L + H C+ P C + G
Sbjct: 65 LNHVLPLKRLILKLDIKCAHAARGCGRVVKLQDLPEHLERCDFAPARCRHAGCG 118
>sp|Q9UPQ7|PZRN3_HUMAN PDZ domain-containing RING finger protein 3 (Ligand of Numb-protein
X 3) (Semaphorin cytoplasmic domain-associated protein
3) (SEMACAP3 protein)
Length = 1066
Score = 41.2 bits (95), Expect = 0.003
Identities = 24/114 (21%), Positives = 52/114 (45%), Gaps = 2/114 (1%)
Frame = +2
Query: 239 EINNDFVCNICNKLMVKACNAPCGCKYCSECIENYLHGKDKFCPGKDKFRQMKMINFEKD 418
+++ D C +C+K++ PCG +C+ C+ ++ ++ CP + + R K+
Sbjct: 11 DVDPDLKCALCHKVLEDPLTTPCGHVFCAGCVLPWV-VQEGSCPARCRGRLS-----AKE 64
Query: 419 VSINHQTNRRIAEIVVKC--SNKNCKFTDELSSMGNHARTCNKNPTSCPYFEMG 574
++ R I ++ +KC + + C +L + H C+ P C + G
Sbjct: 65 LNHVLPLKRLILKLDIKCAYATRGCGRVVKLQQLPEHLERCDFAPARCRHAGCG 118
Database: Non-redundant SwissProt sequences
Posted date: Dec 6, 2005 7:40 AM
Number of letters in database: 68,354,980
Number of sequences in database: 184,735
Database: swissprot.01
Posted date: Dec 6, 2005 8:18 AM
Number of letters in database: 66,202,850
Number of sequences in database: 184,431
Lambda K H
0.318 0.134 0.401
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 65,477,868
Number of Sequences: 369166
Number of extensions: 1254267
Number of successful extensions: 3526
Number of sequences better than 10.0: 10
Number of HSP's better than 10.0 without gapping: 3374
Number of HSP's successfully gapped in prelim test: 0
Number of HSP's that attempted gapping in prelim test: 0
Number of HSP's gapped (non-prelim): 3515
length of database: 68,354,980
effective HSP length: 107
effective length of database: 48,588,335
effective search space used: 6024953540
frameshift window, decay const: 40, 0.1
T: 12
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)