Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= Dr_sW_006_J14
(279 letters)
Database: Non-redundant SwissProt sequences
184,735 sequences; 68,354,980 total letters
Score E
Sequences producing significant alignments: (bits) Value
sp|O35186|CATK_RAT Cathepsin K precursor 72 3e-13
sp|P55097|CATK_MOUSE Cathepsin K precursor 70 2e-12
sp|P43235|CATK_HUMAN Cathepsin K precursor (Cathepsin O) (C... 70 2e-12
sp|P61277|CATK_MACMU Cathepsin K precursor >gi|47117667|sp|... 70 2e-12
sp|P43236|CATK_RABIT Cathepsin K precursor (OC-2 protein) 69 3e-12
sp|Q9GLE3|CATK_PIG Cathepsin K precursor 69 3e-12
sp|P25782|CYSP2_HOMAM Digestive cysteine proteinase 2 precu... 69 4e-12
sp|Q90686|CATK_CHICK Cathepsin K precursor (JTAP-1) 68 7e-12
sp|O60911|CATL2_HUMAN Cathepsin L2 precursor (Cathepsin V) ... 64 8e-11
sp|Q95029|CATL_DROME Cathepsin L precursor (Cysteine protei... 64 1e-10
>sp|O35186|CATK_RAT Cathepsin K precursor
Length = 329
Score = 72.4 bits (176), Expect = 3e-13
Identities = 40/82 (48%), Positives = 50/82 (60%), Gaps = 2/82 (2%)
Frame = +3
Query: 39 CVCKSTV-VANCIGFHNINSCNEKNLPVAVATVGLIFLAIDVGY-SFQQYKQGVYYEAKC 212
C+ +T A C G+ I NEK L AVA VG + ++ID SFQ Y +GVYY+ C
Sbjct: 210 CMYNATAKAAKCRGYREIPVGNEKALKRAVARVGPVSVSIDASLTSFQFYSRGVYYDENC 269
Query: 213 DPTIQNHAVLVVGYGVENGHKY 278
D NHAVLVVGYG + G+KY
Sbjct: 270 DRDNVNHAVLVVGYGTQKGNKY 291
>sp|P55097|CATK_MOUSE Cathepsin K precursor
Length = 329
Score = 70.1 bits (170), Expect = 2e-12
Identities = 40/82 (48%), Positives = 49/82 (59%), Gaps = 2/82 (2%)
Frame = +3
Query: 39 CVCKSTV-VANCIGFHNINSCNEKNLPVAVATVGLIFLAIDVGY-SFQQYKQGVYYEAKC 212
C+ +T A C G+ I NEK L AVA VG I ++ID SFQ Y +GVYY+ C
Sbjct: 210 CMYNATAKAAKCRGYREIPVGNEKALKRAVARVGPISVSIDASLASFQFYSRGVYYDENC 269
Query: 213 DPTIQNHAVLVVGYGVENGHKY 278
D NHAVLVVGYG + G K+
Sbjct: 270 DRDNVNHAVLVVGYGTQKGSKH 291
>sp|P43235|CATK_HUMAN Cathepsin K precursor (Cathepsin O) (Cathepsin X) (Cathepsin O2)
Length = 329
Score = 69.7 bits (169), Expect = 2e-12
Identities = 36/73 (49%), Positives = 46/73 (63%), Gaps = 1/73 (1%)
Frame = +3
Query: 63 ANCIGFHNINSCNEKNLPVAVATVGLIFLAIDVGY-SFQQYKQGVYYEAKCDPTIQNHAV 239
A C G+ I NEK L AVA VG + +AID SFQ Y +GVYY+ C+ NHAV
Sbjct: 219 AKCRGYREIPEGNEKALKRAVARVGPVSVAIDASLTSFQFYSKGVYYDESCNSDNLNHAV 278
Query: 240 LVVGYGVENGHKY 278
L VGYG++ G+K+
Sbjct: 279 LAVGYGIQKGNKH 291
>sp|P61277|CATK_MACMU Cathepsin K precursor
sp|P61276|CATK_MACFA Cathepsin K precursor
Length = 329
Score = 69.7 bits (169), Expect = 2e-12
Identities = 36/73 (49%), Positives = 46/73 (63%), Gaps = 1/73 (1%)
Frame = +3
Query: 63 ANCIGFHNINSCNEKNLPVAVATVGLIFLAIDVGY-SFQQYKQGVYYEAKCDPTIQNHAV 239
A C G+ I NEK L AVA VG + +AID SFQ Y +GVYY+ C+ NHAV
Sbjct: 219 AKCRGYREIPEGNEKALKRAVARVGPVSVAIDASLTSFQFYSKGVYYDESCNSDNLNHAV 278
Query: 240 LVVGYGVENGHKY 278
L VGYG++ G+K+
Sbjct: 279 LAVGYGIQKGNKH 291
>sp|P43236|CATK_RABIT Cathepsin K precursor (OC-2 protein)
Length = 329
Score = 69.3 bits (168), Expect = 3e-12
Identities = 36/73 (49%), Positives = 45/73 (61%), Gaps = 1/73 (1%)
Frame = +3
Query: 63 ANCIGFHNINSCNEKNLPVAVATVGLIFLAIDVGY-SFQQYKQGVYYEAKCDPTIQNHAV 239
A C G+ I NEK L AVA VG + +AID SFQ Y +GVYY+ C NHAV
Sbjct: 219 AKCRGYREIPEGNEKALKRAVARVGPVSVAIDASLTSFQFYSKGVYYDENCSSDNVNHAV 278
Query: 240 LVVGYGVENGHKY 278
L VGYG++ G+K+
Sbjct: 279 LAVGYGIQKGNKH 291
>sp|Q9GLE3|CATK_PIG Cathepsin K precursor
Length = 330
Score = 68.9 bits (167), Expect = 3e-12
Identities = 36/73 (49%), Positives = 45/73 (61%), Gaps = 1/73 (1%)
Frame = +3
Query: 63 ANCIGFHNINSCNEKNLPVAVATVGLIFLAIDVGY-SFQQYKQGVYYEAKCDPTIQNHAV 239
A C G+ I NEK L AVA VG + +AID SFQ Y +GVYY+ C+ NHAV
Sbjct: 220 AKCRGYREIPEGNEKALKRAVARVGPVSVAIDASLTSFQFYSKGVYYDENCNSDNLNHAV 279
Query: 240 LVVGYGVENGHKY 278
L VGYG++ G K+
Sbjct: 280 LAVGYGIQKGKKH 292
>sp|P25782|CYSP2_HOMAM Digestive cysteine proteinase 2 precursor
Length = 323
Score = 68.6 bits (166), Expect = 4e-12
Identities = 36/77 (46%), Positives = 45/77 (58%), Gaps = 1/77 (1%)
Frame = +3
Query: 51 STVVANCIGFHNINSCNEKNLPVAVATVGLIFLAIDVGYS-FQQYKQGVYYEAKCDPTIQ 227
++V A C G NI S +E L AV +G I + ID +S FQ Y GVYYE C P+
Sbjct: 209 NSVAATCSGHTNIASGSETGLQQAVRDIGPISVTIDAAHSSFQFYSSGVYYEPSCSPSYL 268
Query: 228 NHAVLVVGYGVENGHKY 278
+HAVL VGYG E G +
Sbjct: 269 DHAVLAVGYGSEGGQDF 285
>sp|Q90686|CATK_CHICK Cathepsin K precursor (JTAP-1)
Length = 334
Score = 67.8 bits (164), Expect = 7e-12
Identities = 35/73 (47%), Positives = 44/73 (60%), Gaps = 1/73 (1%)
Frame = +3
Query: 63 ANCIGFHNINSCNEKNLPVAVATVGLIFLAIDVGY-SFQQYKQGVYYEAKCDPTIQNHAV 239
A C G+ I NEK L AVA +G + + ID SFQ Y +GVYY+ C+P NHAV
Sbjct: 224 AKCRGYREIPEDNEKALKRAVARIGPVSVGIDASLPSFQFYSRGVYYDTGCNPENINHAV 283
Query: 240 LVVGYGVENGHKY 278
L VGYG + G K+
Sbjct: 284 LAVGYGAQKGTKH 296
>sp|O60911|CATL2_HUMAN Cathepsin L2 precursor (Cathepsin V) (Cathepsin U)
Length = 334
Score = 64.3 bits (155), Expect = 8e-11
Identities = 41/87 (47%), Positives = 49/87 (56%), Gaps = 8/87 (9%)
Frame = +3
Query: 42 VCK---STVVANCIGFHNINSCNEKNLPVAVATVGLIFLAIDVGYS-FQQYKQGVYYEAK 209
+CK VAN GF + EK L AVATVG I +A+D G+S FQ YK G+Y+E
Sbjct: 210 ICKYRPENSVANDTGFTVVAPGKEKALMKAVATVGPISVAMDAGHSSFQFYKSGIYFEPD 269
Query: 210 CDPTIQNHAVLVVGYGVE----NGHKY 278
C +H VLVVGYG E N KY
Sbjct: 270 CSSKNLDHGVLVVGYGFEGANSNNSKY 296
>sp|Q95029|CATL_DROME Cathepsin L precursor (Cysteine proteinase 1) [Contains: Cathepsin
L heavy chain; Cathepsin L light chain]
Length = 341
Score = 63.9 bits (154), Expect = 1e-10
Identities = 38/79 (48%), Positives = 49/79 (62%), Gaps = 2/79 (2%)
Frame = +3
Query: 48 KSTVVANCIGFHNINSCNEKNLPVAVATVGLIFLAIDVGY-SFQQYKQGVYYEAKCDPTI 224
K TV A GF +I +EK + AVATVG + +AID + SFQ Y +GVY E +CD
Sbjct: 225 KGTVGATDRGFTDIPQGDEKKMAEAVATVGPVSVAIDASHESFQFYSEGVYNEPQCDAQN 284
Query: 225 QNHAVLVVGYGV-ENGHKY 278
+H VLVVG+G E+G Y
Sbjct: 285 LDHGVLVVGFGTDESGEDY 303
Database: Non-redundant SwissProt sequences
Posted date: Dec 6, 2005 7:40 AM
Number of letters in database: 68,354,980
Number of sequences in database: 184,735
Database: swissprot.01
Posted date: Dec 6, 2005 8:18 AM
Number of letters in database: 66,202,850
Number of sequences in database: 184,431
Lambda K H
0.318 0.134 0.401
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 36,587,835
Number of Sequences: 369166
Number of extensions: 694987
Number of successful extensions: 2020
Number of sequences better than 10.0: 10
Number of HSP's better than 10.0 without gapping: 1913
Number of HSP's successfully gapped in prelim test: 0
Number of HSP's that attempted gapping in prelim test: 0
Number of HSP's gapped (non-prelim): 1951
length of database: 68,354,980
effective HSP length: 62
effective length of database: 56,901,410
effective search space used: 1707042300
frameshift window, decay const: 40, 0.1
T: 12
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)