Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= Dr_sW_006_H10
(873 letters)
Database: Non-redundant SwissProt sequences
184,735 sequences; 68,354,980 total letters
Score E
Sequences producing significant alignments: (bits) Value
sp|Q9UNH7|SNX6_HUMAN Sorting nexin-6 (TRAF4-associated fact... 191 2e-48
sp|Q5R613|SNX6_PONPY Sorting nexin-6 191 2e-48
sp|Q9Y5X3|SNX5_HUMAN Sorting nexin-5 178 2e-44
sp|Q9D8U8|SNX5_MOUSE Sorting nexin-5 176 6e-44
sp|P25343|RV161_YEAST Reduced viability upon starvation pro... 38 0.042
sp|P30199|EPIP_STAEP Epidermin leader peptide-processing se... 35 0.21
sp|Q8NDV3|SM1L2_HUMAN Structural maintenance of chromosome ... 35 0.21
sp|P50478|AMPH_CHICK Amphiphysin 33 0.79
sp|P32908|SMC1_YEAST Structural maintenance of chromosome 1... 33 1.0
sp|Q9Y5S2|MRCKB_HUMAN Serine/threonine-protein kinase MRCK ... 33 1.4
>sp|Q9UNH7|SNX6_HUMAN Sorting nexin-6 (TRAF4-associated factor 2)
Length = 406
Score = 191 bits (486), Expect = 2e-48
Identities = 95/196 (48%), Positives = 144/196 (73%)
Frame = +1
Query: 58 FFLNEKVYLVDYYLAVREATMKADKMTRQHKTMSDGYIAVSTSLEDAVQPHTGDLGLSST 237
FF +E+ +L++Y+ V++A+ K+D+MTR HK+ +D Y + +SL + D+
Sbjct: 209 FFEHERTFLLEYHNRVKDASAKSDRMTRSHKSAADDYNRIGSSLYALGTQDSTDI--CKF 266
Query: 238 FLALSKVFEEVRKLENRIATDEDLKLSDTLRYYQNDSQAAKALLYRRSRALADYDSASKA 417
FL +S++F++ RK+E R++ DEDLKLSD L+YY +SQAAK LLYRRSR+L DY++A+KA
Sbjct: 267 FLKVSELFDKTRKIEARVSADEDLKLSDLLKYYLRESQAAKDLLYRRSRSLVDYENANKA 326
Query: 418 VEKARIKGKEVAAAEGTQSISYDKFKKISESAKTQIMDFKQRRIAYFKKNLTELTKLQLK 597
++KAR K K+V AE +Q + KF+KISESAK +++DFK RR+A F+KNL EL +L+LK
Sbjct: 327 LDKARAKNKDVLQAETSQQLCCQKFEKISESAKQELIDFKTRRVAAFRKNLVELAELELK 386
Query: 598 HARSHIQVLRTALNAL 645
HA+ ++Q+L+ L L
Sbjct: 387 HAKGNLQLLQNCLAVL 402
>sp|Q5R613|SNX6_PONPY Sorting nexin-6
Length = 406
Score = 191 bits (486), Expect = 2e-48
Identities = 95/196 (48%), Positives = 144/196 (73%)
Frame = +1
Query: 58 FFLNEKVYLVDYYLAVREATMKADKMTRQHKTMSDGYIAVSTSLEDAVQPHTGDLGLSST 237
FF +E+ +L++Y+ V++A+ K+D+MTR HK+ +D Y + +SL + D+
Sbjct: 209 FFEHERTFLLEYHNRVKDASAKSDRMTRSHKSAADDYNRIGSSLYALGTQDSTDI--CKF 266
Query: 238 FLALSKVFEEVRKLENRIATDEDLKLSDTLRYYQNDSQAAKALLYRRSRALADYDSASKA 417
FL +S++F++ RK+E R++ DEDLKLSD L+YY +SQAAK LLYRRSR+L DY++A+KA
Sbjct: 267 FLKVSELFDKTRKIEARVSADEDLKLSDLLKYYLRESQAAKDLLYRRSRSLVDYENANKA 326
Query: 418 VEKARIKGKEVAAAEGTQSISYDKFKKISESAKTQIMDFKQRRIAYFKKNLTELTKLQLK 597
++KAR K K+V AE +Q + KF+KISESAK +++DFK RR+A F+KNL EL +L+LK
Sbjct: 327 LDKARAKNKDVLQAETSQQLCCQKFEKISESAKQELIDFKTRRVAAFRKNLVELAELELK 386
Query: 598 HARSHIQVLRTALNAL 645
HA+ ++Q+L+ L L
Sbjct: 387 HAKGNLQLLQNCLAVL 402
>sp|Q9Y5X3|SNX5_HUMAN Sorting nexin-5
Length = 404
Score = 178 bits (451), Expect = 2e-44
Identities = 86/203 (42%), Positives = 149/203 (73%), Gaps = 1/203 (0%)
Frame = +1
Query: 43 KKKYSFFLNEKVYLVDYYLAVREATMKADKMTRQHKTMSDGYIAVSTSLED-AVQPHTGD 219
K+ FF EK +L++YY ++++ +KADKMTR HK ++D YI + L A++ T
Sbjct: 203 KEVDDFFEQEKNFLINYYNRIKDSCVKADKMTRSHKNVADDYIHTAACLHSLALEEPTV- 261
Query: 220 LGLSSTFLALSKVFEEVRKLENRIATDEDLKLSDTLRYYQNDSQAAKALLYRRSRALADY 399
+ L ++++FE++RK+E R+++DEDLKL++ LRYY + +AAK LLYRR++AL DY
Sbjct: 262 --IKKYLLKVAELFEKLRKVEGRVSSDEDLKLTELLRYYMLNIEAAKDLLYRRTKALIDY 319
Query: 400 DSASKAVEKARIKGKEVAAAEGTQSISYDKFKKISESAKTQIMDFKQRRIAYFKKNLTEL 579
++++KA++KAR+K K+V AE Q KF+++SESAK ++++FK++R+A F+KNL E+
Sbjct: 320 ENSNKALDKARLKSKDVKLAEAHQQECCQKFEQLSESAKEELINFKRKRVAAFRKNLIEM 379
Query: 580 TKLQLKHARSHIQVLRTALNALK 648
++L++KHAR+++ +L++ ++ K
Sbjct: 380 SELEIKHARNNVSLLQSCIDLFK 402
>sp|Q9D8U8|SNX5_MOUSE Sorting nexin-5
Length = 404
Score = 176 bits (447), Expect = 6e-44
Identities = 86/203 (42%), Positives = 148/203 (72%), Gaps = 1/203 (0%)
Frame = +1
Query: 43 KKKYSFFLNEKVYLVDYYLAVREATMKADKMTRQHKTMSDGYIAVSTSLED-AVQPHTGD 219
K+ FF EK +L++YY ++++ KADKMTR HK ++D YI + L A++ T
Sbjct: 203 KEVDDFFEQEKNFLINYYNRIKDSCAKADKMTRSHKNVADDYIHTAACLHSLALEEPTV- 261
Query: 220 LGLSSTFLALSKVFEEVRKLENRIATDEDLKLSDTLRYYQNDSQAAKALLYRRSRALADY 399
+ L ++++FE++RK+E R+++DEDLKL++ LRYY + +AAK LLYRR++AL DY
Sbjct: 262 --IKKYLLKVAELFEKLRKVEGRVSSDEDLKLTELLRYYMLNIEAAKDLLYRRTKALIDY 319
Query: 400 DSASKAVEKARIKGKEVAAAEGTQSISYDKFKKISESAKTQIMDFKQRRIAYFKKNLTEL 579
++++KA++KAR+K K+V AE Q KF+++SESAK ++++FK++R+A F+KNL E+
Sbjct: 320 ENSNKALDKARLKSKDVKLAETHQQECCQKFEQLSESAKEELINFKRKRVAAFRKNLIEM 379
Query: 580 TKLQLKHARSHIQVLRTALNALK 648
++L++KHAR+++ +L++ ++ K
Sbjct: 380 SELEIKHARNNVSLLQSCIDLFK 402
>sp|P25343|RV161_YEAST Reduced viability upon starvation protein 161
Length = 265
Score = 37.7 bits (86), Expect = 0.042
Identities = 31/147 (21%), Positives = 65/147 (44%), Gaps = 6/147 (4%)
Frame = +1
Query: 175 VSTSLEDAVQPHTGDLGLSSTFLALSKVF--EEVRKLENRIATDEDLKLSDTLRYYQNDS 348
+S +D+ G + + +L + F E V++L+ + ++ Y++
Sbjct: 72 ISNLYDDSKYVAGGGYNVGNYYLQCVQDFDSETVKQLDGPLRETVLDPITKFSTYFKEIE 131
Query: 349 QAAKALLYRRSRALADYDSAS----KAVEKARIKGKEVAAAEGTQSISYDKFKKISESAK 516
+A K +R D+D+A + V+K ++ AE S++ D F+ ++ K
Sbjct: 132 EAIK----KRDHKKQDFDAAKAKVRRLVDKPAKDASKLPRAEKELSLAKDIFENLNNQLK 187
Query: 517 TQIMDFKQRRIAYFKKNLTELTKLQLK 597
T++ R+ YF + L K+QL+
Sbjct: 188 TELPQLVSLRVPYFDPSFEALIKIQLR 214
>sp|P30199|EPIP_STAEP Epidermin leader peptide-processing serine protease epiP precursor
Length = 461
Score = 35.4 bits (80), Expect = 0.21
Identities = 22/59 (37%), Positives = 30/59 (50%)
Frame = +1
Query: 331 YYQNDSQAAKALLYRRSRALADYDSASKAVEKARIKGKEVAAAEGTQSISYDKFKKISE 507
Y D+Q K L R DYD+ KA+ A+ KG V AA G I+ K K+I++
Sbjct: 255 YLIKDNQNKKKL---RDDEKVDYDALQKAINYAQKKGSIVVAAVGNDGINVKKVKEINK 310
>sp|Q8NDV3|SM1L2_HUMAN Structural maintenance of chromosome 1-like 2 protein (SMC1beta
protein)
Length = 1235
Score = 35.4 bits (80), Expect = 0.21
Identities = 32/128 (25%), Positives = 59/128 (46%), Gaps = 11/128 (8%)
Frame = +1
Query: 301 EDLKLSDTLRYYQNDSQAAKALLYRRSRALADYDSASKAVEKARIKGKEVAAAEGTQSIS 480
E +K + +YQ SQ LL S+ + S+ +++ + + KE E +
Sbjct: 720 EMIKKKHLVAFYQEQSQLQSELLNIESQCIM----LSEGIKERQRRIKEFQ--EKIDKVE 773
Query: 481 YDKFKKISESAKTQ-IMDFKQRRIA----------YFKKNLTELTKLQLKHARSHIQVLR 627
D F+ E + I +F+ + + ++KK LT L +QL+++RSH++
Sbjct: 774 DDIFQHFCEEIGVENIREFENKHVKRQQEIDQKRYFYKKMLTRLN-VQLEYSRSHLKKKL 832
Query: 628 TALNALKE 651
+N LKE
Sbjct: 833 NKINTLKE 840
>sp|P50478|AMPH_CHICK Amphiphysin
Length = 682
Score = 33.5 bits (75), Expect = 0.79
Identities = 24/97 (24%), Positives = 43/97 (44%), Gaps = 5/97 (5%)
Frame = +1
Query: 322 TLRYYQNDSQAAKALLYRRSRALADYDSASKAVE-----KARIKGKEVAAAEGTQSISYD 486
TL Y K + +RSR L DYDSA +E K + +G+ A E Q +
Sbjct: 120 TLDTYLGQFPDIKTRIAKRSRKLVDYDSARHHLEALQSSKRKDEGRITKAEEEFQK-AQK 178
Query: 487 KFKKISESAKTQIMDFKQRRIAYFKKNLTELTKLQLK 597
F++ + + ++ RR+ ++ ++ L+ K
Sbjct: 179 VFEEFNTDLQEELPSLWSRRVGFYVNTFKNVSSLEAK 215
>sp|P32908|SMC1_YEAST Structural maintenance of chromosome 1 (DA-box protein SMC1)
Length = 1225
Score = 33.1 bits (74), Expect = 1.0
Identities = 39/201 (19%), Positives = 86/201 (42%), Gaps = 27/201 (13%)
Frame = +1
Query: 130 KMTRQHKTMSDGYIAV---STSLEDAVQPHTGDLGLSSTFLALSK--VFEEVRKLENRIA 294
++T+Q +++ + + + + +E +QP +L L +K + +E L+N I
Sbjct: 730 QVTQQKRSLDENRLEIKYHNDLIEKEIQPKITELKKKLDDLENTKDNLVKEKEALQNNIF 789
Query: 295 TDEDLKLSDTLRYYQNDS------------QAAKALLY----------RRSRALADYDSA 408
+ K+ T++ Y+N S Q K +L R S Y+ A
Sbjct: 790 KEFTSKIGFTIKEYENHSGELMRQQSKELQQLQKQILTVENKLQFETDRLSTTQRRYEKA 849
Query: 409 SKAVEKARIKGKEVAAAEGTQSISYDKFKKISESAKTQIMDFKQRRIAYFKKNLTELTKL 588
K +E A+++ K + E + + E K + + +++ + K++ ++
Sbjct: 850 QKDLENAQVEMKSLEEQEYAIEMKIGSIESKLEEHKNHLDELQKKFVT--KQSELNSSED 907
Query: 589 QLKHARSHIQVLRTALNALKE 651
L+ S++QVL+ + +KE
Sbjct: 908 ILEDMNSNLQVLKRERDGIKE 928
>sp|Q9Y5S2|MRCKB_HUMAN Serine/threonine-protein kinase MRCK beta (CDC42-binding protein
kinase beta) (Myotonic dystrophy kinase-related
CDC42-binding kinase beta) (Myotonic dystrophy protein
kinase-like beta) (MRCK beta) (DMPK-like beta)
Length = 1711
Score = 32.7 bits (73), Expect = 1.4
Identities = 32/148 (21%), Positives = 70/148 (47%), Gaps = 15/148 (10%)
Frame = +1
Query: 109 EATMKADKMTRQHKTMSDGYIAVSTSLEDAVQP----HTGDLGLSSTFL--ALSKVFEEV 270
E +++ + R+ + + + +S L+++ Q H LS++ + K+ EE+
Sbjct: 435 EHSLQMEAYERRIRRLEQEKLELSRKLQESTQTVQSLHGSSRALSNSNRDKEIKKLNEEI 494
Query: 271 RKLENRIATDEDL--KLSDT--LRYYQNDSQAAKALLYRRSRALAD-----YDSASKAVE 423
+L+N+IA L +L DT LR + DS L ++ R + + +A E
Sbjct: 495 ERLKNKIADSNRLERQLEDTVALRQEREDSTQRLRGLEKQHRVVRQEKEELHKQLVEASE 554
Query: 424 KARIKGKEVAAAEGTQSISYDKFKKISE 507
+ + + KE+ A + ++ +F +++E
Sbjct: 555 RLKSQAKELKDAHQQRKLALQEFSELNE 582
Database: Non-redundant SwissProt sequences
Posted date: Dec 6, 2005 7:40 AM
Number of letters in database: 68,354,980
Number of sequences in database: 184,735
Database: swissprot.01
Posted date: Dec 6, 2005 8:18 AM
Number of letters in database: 66,202,850
Number of sequences in database: 184,431
Lambda K H
0.318 0.134 0.401
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 84,269,691
Number of Sequences: 369166
Number of extensions: 1462749
Number of successful extensions: 4264
Number of sequences better than 10.0: 10
Number of HSP's better than 10.0 without gapping: 4112
Number of HSP's successfully gapped in prelim test: 0
Number of HSP's that attempted gapping in prelim test: 0
Number of HSP's gapped (non-prelim): 4247
length of database: 68,354,980
effective HSP length: 110
effective length of database: 48,034,130
effective search space used: 8646143400
frameshift window, decay const: 40, 0.1
T: 12
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)