Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= Dr_sW_006_H07
(726 letters)
Database: Non-redundant SwissProt sequences
184,735 sequences; 68,354,980 total letters
Score E
Sequences producing significant alignments: (bits) Value
sp|O00291|HIP1_HUMAN Huntingtin interacting protein 1 (HIP-I) 162 1e-39
sp|O75146|HIP1R_HUMAN Huntingtin-interacting protein 1-rela... 145 1e-34
sp|Q02328|SLAP2_CAEEL Protein SLA2 homolog 144 3e-34
sp|Q9JKY5|HIP1R_MOUSE Huntingtin interacting protein 1 rela... 143 4e-34
sp|Q9P6L5|SLA2_SCHPO Endocytosis protein end4 (SLA2 protein... 112 1e-24
sp|P33338|SLA2_YEAST Protein SLA2 (Transmembrane protein MOP2) 81 2e-15
sp|P54633|TALA_DICDI Filopodin (Talin homolog) 74 4e-13
sp|Q9Y490|TLN1_HUMAN Talin-1 63 9e-10
sp|Q9Y4G6|TLN2_HUMAN Talin-2 62 1e-09
sp|P26039|TLN1_MOUSE Talin-1 62 2e-09
>sp|O00291|HIP1_HUMAN Huntingtin interacting protein 1 (HIP-I)
Length = 1030
Score = 162 bits (409), Expect = 1e-39
Identities = 86/163 (52%), Positives = 111/163 (68%)
Frame = +1
Query: 1 KGTGSVTEFYKKHHKWTEGLISAAKAVGGGATWLCEAADNLLSKDGKFEELVICSREITA 180
+GT S EFY K+ +WTEGLISA+KAVG GAT + +AAD ++ GKFEEL++CS EI A
Sbjct: 846 RGTASPKEFYAKNSRWTEGLISASKAVGWGATVMVDAADLVVQGRGKFEELMVCSHEIAA 905
Query: 181 STTQLVVSSRVKANLSSQNFQNLSQASKGVSDATGKVIANAKNAMKVLEEQGSYNFSNLT 360
ST QLV +S+VKA+ S N L QAS+GV+ AT V+A+ + +EE + +FS++T
Sbjct: 906 STAQLVAASKVKADKDSPNLAQLQQASRGVNQATAGVVASTISGKSQIEETDNMDFSSMT 965
Query: 361 LTQAKRLEMDSQVRVLELENDXXXXXXXXXXXXXXHYQLAGDA 489
LTQ KR EMDSQVRVLELEN+ HY+LAG A
Sbjct: 966 LTQIKRQEMDSQVRVLELENELQKERQKLGELRKKHYELAGVA 1008
>sp|O75146|HIP1R_HUMAN Huntingtin-interacting protein 1-related protein (Hip1-related) (Hip
12)
Length = 1068
Score = 145 bits (366), Expect = 1e-34
Identities = 74/170 (43%), Positives = 108/170 (63%)
Frame = +1
Query: 1 KGTGSVTEFYKKHHKWTEGLISAAKAVGGGATWLCEAADNLLSKDGKFEELVICSREITA 180
+G + EFY K+ +WTEGLISA+KAVG GAT L EAAD ++ GK+EEL++CS EI A
Sbjct: 853 RGAATQQEFYAKNSRWTEGLISASKAVGWGATQLVEAADKVVLHTGKYEELIVCSHEIAA 912
Query: 181 STTQLVVSSRVKANLSSQNFQNLSQASKGVSDATGKVIANAKNAMKVLEEQGSYNFSNLT 360
ST QLV +S+VKAN S + L + S+ V++ V+A+ K+ + +E++ + +FS L+
Sbjct: 913 STAQLVAASKVKANKHSPHLSRLQECSRTVNERAANVVASTKSGQEQIEDRDTMDFSGLS 972
Query: 361 LTQAKRLEMDSQVRVLELENDXXXXXXXXXXXXXXHYQLAGDAADQNDEL 510
L + K+ EM++QVRVLELE HY LAG + +E+
Sbjct: 973 LIKLKKQEMETQVRVLELEKTLEAERMRLGELRKQHYVLAGASGSPGEEV 1022
>sp|Q02328|SLAP2_CAEEL Protein SLA2 homolog
Length = 927
Score = 144 bits (362), Expect = 3e-34
Identities = 78/169 (46%), Positives = 106/169 (62%)
Frame = +1
Query: 1 KGTGSVTEFYKKHHKWTEGLISAAKAVGGGATWLCEAADNLLSKDGKFEELVICSREITA 180
K GS EFYK++H+WTEGL+SAAKAVG A L E+AD +++ GKFE L++ ++EI A
Sbjct: 755 KAGGSPAEFYKRNHQWTEGLLSAAKAVGVAARVLVESADGVVTGKGKFEHLIVAAQEIAA 814
Query: 181 STTQLVVSSRVKANLSSQNFQNLSQASKGVSDATGKVIANAKNAMKVLEEQGSYNFSNLT 360
ST QL VSSRVKA+ S LS A+K V+ T +V+A KN L ++GS +FS L+
Sbjct: 815 STAQLFVSSRVKADKDSSKLDALSVAAKAVNQNTAQVVAAVKNGQTTLNDEGSLDFSYLS 874
Query: 361 LTQAKRLEMDSQVRVLELENDXXXXXXXXXXXXXXHYQLAGDAADQNDE 507
L AK+ EM+SQV++LELE HY +A A++ E
Sbjct: 875 LHAAKKEEMESQVKMLELEQSLNQERAKLAALRKQHYHMAQLVANKEGE 923
>sp|Q9JKY5|HIP1R_MOUSE Huntingtin interacting protein 1 related (Hip1-related)
Length = 1068
Score = 143 bits (361), Expect = 4e-34
Identities = 73/169 (43%), Positives = 108/169 (63%)
Frame = +1
Query: 1 KGTGSVTEFYKKHHKWTEGLISAAKAVGGGATWLCEAADNLLSKDGKFEELVICSREITA 180
+G + EFY K+ +WTEGLISA+KAVG GAT L E+AD ++ GK+EEL++CS EI A
Sbjct: 853 RGAATQQEFYAKNSRWTEGLISASKAVGWGATQLVESADKVVLHMGKYEELIVCSHEIAA 912
Query: 181 STTQLVVSSRVKANLSSQNFQNLSQASKGVSDATGKVIANAKNAMKVLEEQGSYNFSNLT 360
ST QLV +S+VKAN +S + L + S+ V++ V+A+ K+ + +E++ + +FS L+
Sbjct: 913 STAQLVAASKVKANKNSPHLSRLQECSRTVNERAANVVASTKSGQEQIEDRDTMDFSGLS 972
Query: 361 LTQAKRLEMDSQVRVLELENDXXXXXXXXXXXXXXHYQLAGDAADQNDE 507
L + K+ EM++QVRVLELE HY LAG ++E
Sbjct: 973 LIKLKKQEMETQVRVLELEKTLEAERVRLGELRKQHYVLAGGMGTPSEE 1021
>sp|Q9P6L5|SLA2_SCHPO Endocytosis protein end4 (SLA2 protein homolog)
Length = 1092
Score = 112 bits (279), Expect = 1e-24
Identities = 57/141 (40%), Positives = 91/141 (64%)
Frame = +1
Query: 1 KGTGSVTEFYKKHHKWTEGLISAAKAVGGGATWLCEAADNLLSKDGKFEELVICSREITA 180
+G+ S FYKKH++WTEGLISAAKAV T L E AD +++ FE L++ ++A
Sbjct: 931 RGSSSRGAFYKKHNRWTEGLISAAKAVARATTTLIETADGVVNGTSSFEHLIVACNGVSA 990
Query: 181 STTQLVVSSRVKANLSSQNFQNLSQASKGVSDATGKVIANAKNAMKVLEEQGSYNFSNLT 360
+T QLV +SRVKAN +S+ +L A+K V++A ++ ++ +E +FS+L
Sbjct: 991 ATAQLVAASRVKANFASKVQDHLEDAAKAVTEACKALVRQVESVALKAKEVQHEDFSSLG 1050
Query: 361 LTQAKRLEMDSQVRVLELEND 423
+ + +R E++ QV++L+LEND
Sbjct: 1051 VHEYRRKEIEQQVQILKLEND 1071
>sp|P33338|SLA2_YEAST Protein SLA2 (Transmembrane protein MOP2)
Length = 968
Score = 81.3 bits (199), Expect = 2e-15
Identities = 51/143 (35%), Positives = 77/143 (53%), Gaps = 9/143 (6%)
Frame = +1
Query: 16 VTEFYKKHHKWTEGLISAAKAVGGGATWLCEAADNLLSKDGKF----EELVICSREITAS 183
+ +FY K+ +WTEGLISAAKAV G L A L++ + E+ ++ S+E+ AS
Sbjct: 805 LNQFYLKNSRWTEGLISAAKAVAGATNVLITTASKLITSEDNENTSPEQFIVASKEVAAS 864
Query: 184 TTQLVVSSRVKANLSSQNFQNLSQASKGVSDATGKVIANAKNAMKVLEEQGSYNFSNLTL 363
T QLV +SRVK ++ S+ L SK V+DA + + M ++E+ S + L
Sbjct: 865 TIQLVAASRVKTSIHSKAQDKLEHCSKDVTDACRSL---GNHVMGMIEDDHSTSQQQQPL 921
Query: 364 T-----QAKRLEMDSQVRVLELE 417
K EM+ QV +L+LE
Sbjct: 922 DFTSEHTLKTAEMEQQVEILKLE 944
>sp|P54633|TALA_DICDI Filopodin (Talin homolog)
Length = 2492
Score = 73.9 bits (180), Expect = 4e-13
Identities = 50/142 (35%), Positives = 76/142 (53%), Gaps = 3/142 (2%)
Frame = +1
Query: 7 TGSVTEFYKKHHKWTEGLISAAKAVGGGATWLCEAADNLLSKDGKFEELVICSREITAST 186
+GSV YK W+ GLISAAK VG L EAA + + EEL+ +R + A+T
Sbjct: 2335 SGSV---YKADPTWSNGLISAAKGVGAATHRLVEAAMKSATGKAEEEELIATARSVAAAT 2391
Query: 187 TQLVVSSRVKANLSSQN---FQNLSQASKGVSDATGKVIANAKNAMKVLEEQGSYNFSNL 357
LV +SR K+ Q+ +LS A++ V+ AT ++A AK A E+Q
Sbjct: 2392 ALLVSASRAKSGDDYQSQAAHSHLSTAARQVASATSDLVAAAKAATIFDEQQQEEEQEQF 2451
Query: 358 TLTQAKRLEMDSQVRVLELEND 423
T +K E++ Q+++L+LE +
Sbjct: 2452 NFTGSKVKELEQQMKILKLEKE 2473
>sp|Q9Y490|TLN1_HUMAN Talin-1
Length = 2541
Score = 62.8 bits (151), Expect = 9e-10
Identities = 32/97 (32%), Positives = 56/97 (57%)
Frame = +1
Query: 43 KWTEGLISAAKAVGGGATWLCEAADNLLSKDGKFEELVICSREITASTTQLVVSSRVKAN 222
+W++GLISAA+ V LCEAA+ + E+L+ ++++ AST QL+V+ +VKA+
Sbjct: 2388 QWSQGLISAARMVAAATNNLCEAANAAVQGHASQEKLISSAKQVAASTAQLLVACKVKAD 2447
Query: 223 LSSQNFQNLSQASKGVSDATGKVIANAKNAMKVLEEQ 333
S+ + L A V A+ ++ A+ A E++
Sbjct: 2448 QDSEAMKRLQAAGNAVKRASDNLVKAAQKAAAFEEQE 2484
>sp|Q9Y4G6|TLN2_HUMAN Talin-2
Length = 2542
Score = 62.4 bits (150), Expect = 1e-09
Identities = 33/101 (32%), Positives = 57/101 (56%)
Frame = +1
Query: 10 GSVTEFYKKHHKWTEGLISAAKAVGGGATWLCEAADNLLSKDGKFEELVICSREITASTT 189
GS+ +W++GLISAA+ V + LCEAA+ + E+L+ ++++ AST
Sbjct: 2378 GSIPANAADDGQWSQGLISAARMVAAATSSLCEAANASVQGHASEEKLISSAKQVAASTA 2437
Query: 190 QLVVSSRVKANLSSQNFQNLSQASKGVSDATGKVIANAKNA 312
QL+V+ +VKA+ S+ + L A V A+ ++ A+ A
Sbjct: 2438 QLLVACKVKADQDSEAMRRLQAAGNAVKRASDNLVRAAQKA 2478
>sp|P26039|TLN1_MOUSE Talin-1
Length = 2541
Score = 61.6 bits (148), Expect = 2e-09
Identities = 31/90 (34%), Positives = 53/90 (58%)
Frame = +1
Query: 43 KWTEGLISAAKAVGGGATWLCEAADNLLSKDGKFEELVICSREITASTTQLVVSSRVKAN 222
+W++GLISAA+ V LCEAA+ + E+L+ ++++ AST QL+V+ +VKA+
Sbjct: 2388 QWSQGLISAARMVAAATNNLCEAANAAVQGHASQEKLISSAKQVAASTAQLLVACKVKAD 2447
Query: 223 LSSQNFQNLSQASKGVSDATGKVIANAKNA 312
S+ + L A V A+ ++ A+ A
Sbjct: 2448 QDSEAMKRLQAAGNAVKRASDNLVKAAQKA 2477
Database: Non-redundant SwissProt sequences
Posted date: Dec 6, 2005 7:40 AM
Number of letters in database: 68,354,980
Number of sequences in database: 184,735
Database: swissprot.01
Posted date: Dec 6, 2005 8:18 AM
Number of letters in database: 66,202,850
Number of sequences in database: 184,431
Lambda K H
0.318 0.134 0.401
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 75,245,110
Number of Sequences: 369166
Number of extensions: 1372079
Number of successful extensions: 3838
Number of sequences better than 10.0: 10
Number of HSP's better than 10.0 without gapping: 3740
Number of HSP's successfully gapped in prelim test: 0
Number of HSP's that attempted gapping in prelim test: 0
Number of HSP's gapped (non-prelim): 3836
length of database: 68,354,980
effective HSP length: 107
effective length of database: 48,588,335
effective search space used: 6510836890
frameshift window, decay const: 40, 0.1
T: 12
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)