Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= Dr_sW_006_H01
(852 letters)
Database: Non-redundant SwissProt sequences
184,735 sequences; 68,354,980 total letters
Score E
Sequences producing significant alignments: (bits) Value
sp|P20060|HEXB_MOUSE Beta-hexosaminidase beta chain precurs... 86 2e-16
sp|P49614|HEXB_FELCA Beta-hexosaminidase beta chain precurs... 83 1e-15
sp|Q29548|HEXB_PIG Beta-hexosaminidase beta chain precursor... 82 2e-15
sp|P07686|HEXB_HUMAN Beta-hexosaminidase beta chain precurs... 77 8e-14
sp|P29416|HEXA_MOUSE Beta-hexosaminidase alpha chain precur... 76 1e-13
sp|Q22492|HEXA_CAEEL Probable beta-hexosaminidase A precurs... 71 4e-12
sp|P06865|HEXA_HUMAN Beta-hexosaminidase alpha chain precur... 67 6e-11
sp|P13723|HEXA_DICDI Beta-hexosaminidase A precursor (N-ace... 64 7e-10
sp|P49009|HEXA_ENTHI Beta-hexosaminidase alpha chain precur... 55 2e-07
sp|Q86M34|HEXB_ENTHI Beta-hexosaminidase beta chain precurs... 54 4e-07
>sp|P20060|HEXB_MOUSE Beta-hexosaminidase beta chain precursor
(N-acetyl-beta-glucosaminidase)
(Beta-N-acetylhexosaminidase) (Hexosaminidase B)
Length = 536
Score = 85.5 bits (210), Expect = 2e-16
Identities = 41/100 (41%), Positives = 57/100 (57%)
Frame = +2
Query: 5 YGAQWLNHYQCDPGDEYGNQMVMNDYSNVPVNENWRDNILGGEAAMWMEFLDAENVLPRI 184
YG W N+Y+ +P N +E + ++GGEA +W EF+DA N+ PR+
Sbjct: 435 YGQDWKNYYKVEP-------------LNFEGSEKQKQLVIGGEACLWGEFVDATNLTPRL 481
Query: 185 WPLASAAAERLWSPNFINNAEKAAPRLEELRCRMLARSIS 304
WP ASA ERLWSP + + E A RL RCRM++R I+
Sbjct: 482 WPRASAVGERLWSPKTVTDLENAYKRLAVHRCRMVSRGIA 521
>sp|P49614|HEXB_FELCA Beta-hexosaminidase beta chain precursor
(N-acetyl-beta-glucosaminidase)
(Beta-N-acetylhexosaminidase) (Hexosaminidase B)
Length = 499
Score = 82.8 bits (203), Expect = 1e-15
Identities = 43/100 (43%), Positives = 55/100 (55%)
Frame = +2
Query: 5 YGAQWLNHYQCDPGDEYGNQMVMNDYSNVPVNENWRDNILGGEAAMWMEFLDAENVLPRI 184
YG W N+Y+ DP G+Q + ++GGEA +W EF+DA N+ PR+
Sbjct: 398 YGQDWRNYYKVDPLHFDGSQ-------------EQKKLVIGGEACLWGEFVDATNLTPRL 444
Query: 185 WPLASAAAERLWSPNFINNAEKAAPRLEELRCRMLARSIS 304
WP ASA ERLWSP I + A RL RCRM+ R IS
Sbjct: 445 WPRASAVGERLWSPEDITSVGNAYNRLTVHRCRMVRRGIS 484
>sp|Q29548|HEXB_PIG Beta-hexosaminidase beta chain precursor
(N-acetyl-beta-glucosaminidase)
(Beta-N-acetylhexosaminidase) (Hexosaminidase B) (65 kDa
epididymal boar protein)
Length = 531
Score = 81.6 bits (200), Expect = 2e-15
Identities = 40/100 (40%), Positives = 55/100 (55%)
Frame = +2
Query: 5 YGAQWLNHYQCDPGDEYGNQMVMNDYSNVPVNENWRDNILGGEAAMWMEFLDAENVLPRI 184
YG W N+Y+ +P D P ++ R +LGGEA +W E++DA N+ PR+
Sbjct: 430 YGQDWKNYYEVEPQD-------------FPGSDKERKRVLGGEACLWGEYVDATNLTPRL 476
Query: 185 WPLASAAAERLWSPNFINNAEKAAPRLEELRCRMLARSIS 304
WP ASA ERLWS + + A RL RCRM+ R I+
Sbjct: 477 WPRASAVGERLWSHKDVRDIHDAYSRLTIHRCRMVRRGIA 516
>sp|P07686|HEXB_HUMAN Beta-hexosaminidase beta chain precursor
(N-acetyl-beta-glucosaminidase)
(Beta-N-acetylhexosaminidase) (Hexosaminidase B)
(Cervical cancer proto-oncogene 7) (HCC-7) [Contains:
Beta-hexosaminidase beta-B chain; Beta-hexosaminidase
beta-A chain]
Length = 556
Score = 76.6 bits (187), Expect = 8e-14
Identities = 38/100 (38%), Positives = 53/100 (53%)
Frame = +2
Query: 5 YGAQWLNHYQCDPGDEYGNQMVMNDYSNVPVNENWRDNILGGEAAMWMEFLDAENVLPRI 184
YG W +Y+ +P D G Q + +GGEA +W E++DA N+ PR+
Sbjct: 456 YGQDWRKYYKVEPLDFGGTQ-------------KQKQLFIGGEACLWGEYVDATNLTPRL 502
Query: 185 WPLASAAAERLWSPNFINNAEKAAPRLEELRCRMLARSIS 304
WP ASA ERLWS + + + A RL RCRM+ R I+
Sbjct: 503 WPRASAVGERLWSSKDVRDMDDAYDRLTRHRCRMVERGIA 542
>sp|P29416|HEXA_MOUSE Beta-hexosaminidase alpha chain precursor
(N-acetyl-beta-glucosaminidase)
(Beta-N-acetylhexosaminidase) (Hexosaminidase A)
Length = 528
Score = 76.3 bits (186), Expect = 1e-13
Identities = 41/118 (34%), Positives = 60/118 (50%)
Frame = +2
Query: 2 EYGAQWLNHYQCDPGDEYGNQMVMNDYSNVPVNENWRDNILGGEAAMWMEFLDAENVLPR 181
+YG W + Y+ +P +G + ++GGEA MW E++D+ N++PR
Sbjct: 425 KYGPDWKDMYKVEPLAFHGTP-------------EQKALVIGGEACMWGEYVDSTNLVPR 471
Query: 182 IWPLASAAAERLWSPNFINNAEKAAPRLEELRCRMLARSISTGVASGAGDCGQISERS 355
+WP A A AERLWS N N + A RL RC ++ R I S G C Q E++
Sbjct: 472 LWPRAGAVAERLWSSNLTTNIDFAFKRLSHFRCELVRRGIQAQPIS-VGYCEQEFEQT 528
>sp|Q22492|HEXA_CAEEL Probable beta-hexosaminidase A precursor
(N-acetyl-beta-glucosaminidase)
(Beta-N-acetylhexosaminidase)
Length = 555
Score = 70.9 bits (172), Expect = 4e-12
Identities = 42/110 (38%), Positives = 57/110 (51%), Gaps = 12/110 (10%)
Frame = +2
Query: 2 EYGAQWLN-----------HYQCDPGDEYGNQMVMNDYSNVPVNENWRDNILGGEAAMWM 148
+YGA W + +Y CDP + G ++ + GG AA+W
Sbjct: 432 KYGADWRDEIRGTAPSNSRYYYCDPTNFNGTVAQ-------------KELVWGGIAAIWG 478
Query: 149 EFLDAENVLPRIWPLASAAAERLWSP-NFINNAEKAAPRLEELRCRMLAR 295
E +D N+ R+WP ASAAAERLWSP AE A PR+ ELRCR+++R
Sbjct: 479 ELVDNTNIEARLWPRASAAAERLWSPAEKTQRAEDAWPRMHELRCRLVSR 528
>sp|P06865|HEXA_HUMAN Beta-hexosaminidase alpha chain precursor
(N-acetyl-beta-glucosaminidase)
(Beta-N-acetylhexosaminidase) (Hexosaminidase A)
Length = 529
Score = 67.0 bits (162), Expect = 6e-11
Identities = 32/79 (40%), Positives = 46/79 (58%)
Frame = +2
Query: 119 ILGGEAAMWMEFLDAENVLPRIWPLASAAAERLWSPNFINNAEKAAPRLEELRCRMLARS 298
++GGEA MW E++D N++PR+WP A A AERLWS ++ A RL RC +L R
Sbjct: 452 VIGGEACMWGEYVDNTNLVPRLWPRAGAVAERLWSNKLTSDLTFAYERLSHFRCELLRRG 511
Query: 299 ISTGVASGAGDCGQISERS 355
+ + G C Q E++
Sbjct: 512 VQAQPLN-VGFCEQEFEQT 529
>sp|P13723|HEXA_DICDI Beta-hexosaminidase A precursor (N-acetyl-beta-glucosaminidase)
(Beta-N-acetylhexosaminidase)
Length = 532
Score = 63.5 bits (153), Expect = 7e-10
Identities = 35/103 (33%), Positives = 49/103 (47%)
Frame = +2
Query: 2 EYGAQWLNHYQCDPGDEYGNQMVMNDYSNVPVNENWRDNILGGEAAMWMEFLDAENVLPR 181
E+ W + Y DP + N+ N +NI+GGEA MW E ++ N R
Sbjct: 411 EWQDTWQDFYAADPTN------------NISTNA---ENIIGGEATMWAEQINQVNWDVR 455
Query: 182 IWPLASAAAERLWSPNFINNAEKAAPRLEELRCRMLARSISTG 310
+WP A AERLWS +N+ A PR+ C + R I +G
Sbjct: 456 VWPRAIGIAERLWSAQSVNSVSLALPRIGHFTCDLSRRGIQSG 498
>sp|P49009|HEXA_ENTHI Beta-hexosaminidase alpha chain precursor
(N-acetyl-beta-glucosaminidase) (Beta-GlcNAcase)
(Beta-N-acetylhexosaminidase)
Length = 564
Score = 55.1 bits (131), Expect = 2e-07
Identities = 32/98 (32%), Positives = 47/98 (47%), Gaps = 3/98 (3%)
Frame = +2
Query: 80 YSNVPV---NENWRDNILGGEAAMWMEFLDAENVLPRIWPLASAAAERLWSPNFINNAEK 250
Y N PV + + ++N+LGGE W E D +N R++ SA AERLWS + + E
Sbjct: 467 YDNDPVKSLSSSEKENVLGGEGCSWGESTDEQNFFDRVFQRYSAIAERLWSKESVVDKES 526
Query: 251 AAPRLEELRCRMLARSISTGVASGAGDCGQISERSSNN 364
R LRC + R I G Q+ ++ +N
Sbjct: 527 HEVRANYLRCLDVRRDIMKGTGPLYHSFCQLPKKEKSN 564
>sp|Q86M34|HEXB_ENTHI Beta-hexosaminidase beta chain precursor
(N-acetyl-beta-glucosaminidase) (Beta-GlcNAcase)
(Beta-N-acetylhexosaminidase)
Length = 565
Score = 54.3 bits (129), Expect = 4e-07
Identities = 30/80 (37%), Positives = 40/80 (50%), Gaps = 3/80 (3%)
Frame = +2
Query: 80 YSNVPVNE---NWRDNILGGEAAMWMEFLDAENVLPRIWPLASAAAERLWSPNFINNAEK 250
Y N P+ E + N+LGGEA W E +D +N R++ SA AER WS I + E
Sbjct: 471 YRNDPIKELDYATKQNVLGGEACSWDESVDEQNFFDRVFQRFSAVAERFWSSEDITDPES 530
Query: 251 AAPRLEELRCRMLARSISTG 310
R +RC L R+ G
Sbjct: 531 HEVRANYVRCLGLRRNFLKG 550
Database: Non-redundant SwissProt sequences
Posted date: Dec 6, 2005 7:40 AM
Number of letters in database: 68,354,980
Number of sequences in database: 184,735
Database: swissprot.01
Posted date: Dec 6, 2005 8:18 AM
Number of letters in database: 66,202,850
Number of sequences in database: 184,431
Lambda K H
0.318 0.134 0.401
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 87,683,588
Number of Sequences: 369166
Number of extensions: 1614703
Number of successful extensions: 4048
Number of sequences better than 10.0: 10
Number of HSP's better than 10.0 without gapping: 3853
Number of HSP's successfully gapped in prelim test: 0
Number of HSP's that attempted gapping in prelim test: 0
Number of HSP's gapped (non-prelim): 4032
length of database: 68,354,980
effective HSP length: 109
effective length of database: 48,218,865
effective search space used: 8390082510
frameshift window, decay const: 40, 0.1
T: 12
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)