Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= Dr_sW_006_G11
(937 letters)
Database: Non-redundant SwissProt sequences
184,735 sequences; 68,354,980 total letters
Score E
Sequences producing significant alignments: (bits) Value
sp|Q24020|FLII_DROME Flightless-I protein 275 1e-73
sp|Q13045|FLII_HUMAN Flightless-I protein homolog 236 5e-62
sp|Q9JJ28|FLII_MOUSE Flightless I protein homolog 234 3e-61
sp|P34268|FLII_CAEEL Flightless-I protein homolog 208 2e-53
sp|Q6UWE0|LRSM1_HUMAN Ubiquitin ligase protein LRSAM1 (Leuc... 59 3e-08
sp|Q96RT1|LAP2_HUMAN LAP2 protein (Erbb2-interacting protei... 57 7e-08
sp|P10733|SEVE_DICDI Severin 57 1e-07
sp|Q9V780|LAP1_DROME Lap1 protein 57 1e-07
sp|Q01730|RSU1_MOUSE Ras suppressor protein 1 (Rsu-1) (RSP-1) 56 1e-07
sp|Q15404|RSU1_HUMAN Ras suppressor protein 1 (Rsu-1) (RSP-1) 56 1e-07
>sp|Q24020|FLII_DROME Flightless-I protein
Length = 1256
Score = 275 bits (704), Expect = 1e-73
Identities = 154/315 (48%), Positives = 201/315 (63%), Gaps = 4/315 (1%)
Frame = +3
Query: 3 ELSGLVDCWPNLEVXXXXXXXXXXXXXFITRLSKLKKLYVDENNLTFNGIPPGIGKLTNL 182
EL+ V+ W LE + +L KL++L V++N L F GIP GIGKL L
Sbjct: 256 ELTAGVELWQRLESLNLSRNQLVALPAALCKLPKLRRLLVNDNKLNFEGIPSGIGKLGAL 315
Query: 183 EVFSASENLLENIPEGLCRCGQLKHLNLKMNKLVTLPDAINVLIESLKTFNIENNPHLKM 362
EVFSA+ NLLE +PEGLCRCG LK LNL N+L+TLPDAI+ L+E L ++ NNP L M
Sbjct: 316 EVFSAANNLLEMVPEGLCRCGALKQLNLSCNRLITLPDAIH-LLEGLDQLDLRNNPELVM 374
Query: 363 PPKLEENDSKSKYSFYNIDFSLETQMQLARGAPVKTSVQNVTQKDTASRIRRLRRKKIDE 542
PPK E + FYNIDFSL+TQ++LA A + + T KD+ +R RLRR E
Sbjct: 375 PPKPSEASKATSLEFYNIDFSLQTQLRLAGAAVPPSMPSSATPKDSTARKIRLRRGPRSE 434
Query: 543 KNEKSDSKRVLEGMQKVAKDKD----AVMEDQEKETIKSAKRWQDAIAKPNLDYSRVFDD 710
++ D+ +VL+GM+ VAKDKD AV ED + E++K KRW +++ KP LDYS+ F+
Sbjct: 435 GDQ--DAAKVLKGMKDVAKDKDNEAGAVPEDGKPESLK-PKRWDESLEKPQLDYSKFFEK 491
Query: 711 DIGTEPGIEIWDIDEFYPRKITEEVPVGTFYNGDCYIILHTRQDEKNHNSLIHSIYYWIG 890
D G PG+ IW+I+ F P KI EEV G FY GDCYI+L T+ D+ L I++WIG
Sbjct: 492 DDGQLPGLTIWEIENFLPNKI-EEVVHGKFYEGDCYIVLKTKFDDL--GLLDWEIFFWIG 548
Query: 891 NIATLDKVTSAAVHA 935
N ATLDK AA+HA
Sbjct: 549 NEATLDKRACAAIHA 563
Score = 54.7 bits (130), Expect = 4e-07
Identities = 31/95 (32%), Positives = 50/95 (52%)
Frame = +3
Query: 87 ITRLSKLKKLYVDENNLTFNGIPPGIGKLTNLEVFSASENLLENIPEGLCRCGQLKHLNL 266
+T LS L+ L + N L +GIPP + L L S N L+ +PEGL R L LNL
Sbjct: 71 LTELSCLRSLDLRHNQLKNSGIPPELFHLEELTTLDLSHNKLKEVPEGLERAKNLIVLNL 130
Query: 267 KMNKLVTLPDAINVLIESLKTFNIENNPHLKMPPK 371
N++ ++P + + + L ++ +N +PP+
Sbjct: 131 SNNQIESIPTPLFIHLTDLLFLDLSHNRLETLPPQ 165
>sp|Q13045|FLII_HUMAN Flightless-I protein homolog
Length = 1269
Score = 236 bits (603), Expect = 5e-62
Identities = 136/316 (43%), Positives = 185/316 (58%), Gaps = 5/316 (1%)
Frame = +3
Query: 3 ELSGLVDCWPNLEVXXXXXXXXXXXXXFITRLSKLKKLYVDENNLTFNGIPPGIGKLTNL 182
ELS +D W ++E I +LSKLKKLY++ N L F+G+P GIGKLTNL
Sbjct: 260 ELSLCIDQWVHVETLNLSRNQLTSLPSAICKLSKLKKLYLNSNKLDFDGLPSGIGKLTNL 319
Query: 183 EVFSASENLLENIPEGLCRCGQLKHLNLKMNKLVTLPDAINVLIESLKTFNIENNPHLKM 362
E F A+ N LE +PE LCRC +L+ L L N LVTLP+AI+ L E ++ ++ NP+L M
Sbjct: 320 EEFMAANNNLELVPESLCRCPKLRKLVLNKNHLVTLPEAIHFLTE-IEVLDVRENPNLVM 378
Query: 363 PPKLEENDSKSKYSFYNIDFSLETQMQLARGAPVKTSVQNVT---QKDTASRIRRLRRKK 533
PPK + ++ +YNIDFSL+ Q++LA +P + KD +R RLRR+K
Sbjct: 379 PPKPADRAAE----WYNIDFSLQNQLRLAGASPATVAAAAAAGSGPKDPMARKMRLRRRK 434
Query: 534 IDEKNEKSDSKRVLEGMQKVAKDKDAVMEDQEKETIKSAK--RWQDAIAKPNLDYSRVFD 707
+ + +K+VL+GM VA++K+ E+ S K RW + KP LDYS F
Sbjct: 435 --DSAQDDQAKQVLKGMSDVAQEKNKKQEESADARAPSGKVRRWDQGLEKPRLDYSEFFT 492
Query: 708 DDIGTEPGIEIWDIDEFYPRKITEEVPVGTFYNGDCYIILHTRQDEKNHNSLIHSIYYWI 887
+D+G PG+ IW I+ F P + EE G FY DCYI+L T D+ SL IYYWI
Sbjct: 493 EDVGQLPGLTIWQIENFVP-VLVEEAFHGKFYEADCYIVLKTFLDDS--GSLNWEIYYWI 549
Query: 888 GNIATLDKVTSAAVHA 935
G ATLDK +A+HA
Sbjct: 550 GGEATLDKKACSAIHA 565
Score = 46.2 bits (108), Expect = 1e-04
Identities = 26/96 (27%), Positives = 46/96 (47%)
Frame = +3
Query: 87 ITRLSKLKKLYVDENNLTFNGIPPGIGKLTNLEVFSASENLLENIPEGLCRCGQLKHLNL 266
++ L L+ + N+L +G+P I KL +L V S N L P L + LNL
Sbjct: 75 LSSLPSLRAIVARANSLKNSGVPDDIFKLDDLSVLDLSHNQLTECpreLENAKNMLVLNL 134
Query: 267 KMNKLVTLPDAINVLIESLKTFNIENNPHLKMPPKL 374
N + T+P+ + + + L ++ N +PP++
Sbjct: 135 SHNSIDTIPNQLFINLTDLLYLDLSENRLESLPPQM 170
Score = 37.4 bits (85), Expect = 0.061
Identities = 24/90 (26%), Positives = 43/90 (47%)
Frame = +3
Query: 96 LSKLKKLYVDENNLTFNGIPPGIGKLTNLEVFSASENLLENIPEGLCRCGQLKHLNLKMN 275
++ L+ L++ T + +P + L+NL S N L +PE L L+ LNL N
Sbjct: 197 MTALQTLHLRSTQRTQSNLPTSLEGLSNLADVDLSCNDLTRVPECLYTLPSLRRLNLSSN 256
Query: 276 KLVTLPDAINVLIESLKTFNIENNPHLKMP 365
++ L I+ + ++T N+ N +P
Sbjct: 257 QITELSLCIDQWVH-VETLNLSRNQLTSLP 285
>sp|Q9JJ28|FLII_MOUSE Flightless I protein homolog
Length = 1271
Score = 234 bits (596), Expect = 3e-61
Identities = 136/316 (43%), Positives = 184/316 (58%), Gaps = 5/316 (1%)
Frame = +3
Query: 3 ELSGLVDCWPNLEVXXXXXXXXXXXXXFITRLSKLKKLYVDENNLTFNGIPPGIGKLTNL 182
ELS +D W +LE I +L+KLKKLY++ N L F+G+P GIGKLT+L
Sbjct: 260 ELSLCIDQWVHLETLNLSRNQLTSLPSAICKLTKLKKLYLNSNKLDFDGLPSGIGKLTSL 319
Query: 183 EVFSASENLLENIPEGLCRCGQLKHLNLKMNKLVTLPDAINVLIESLKTFNIENNPHLKM 362
E F A+ N LE IPE LCRC +LK L L N+LVTLP+AI+ L E ++ ++ NP L M
Sbjct: 320 EEFMAANNNLELIPESLCRCPKLKKLVLNKNRLVTLPEAIHFLTE-IQVLDVRENPSLVM 378
Query: 363 PPKLEENDSKSKYSFYNIDFSLETQMQLARGAPVKTSVQNVT---QKDTASRIRRLRRKK 533
PPK + ++ +YNIDFSL+ Q++LA +P + KD +R RLRR+K
Sbjct: 379 PPKPADRTAE----WYNIDFSLQNQLRLAGASPATVAAAAAVGSGSKDPLARKMRLRRRK 434
Query: 534 IDEKNEKSDSKRVLEGMQKVAKDKDAVMEDQEKETIKSAK--RWQDAIAKPNLDYSRVFD 707
+ + +K+VL+GM VA++K+ E+ K RW + KP LDYS F
Sbjct: 435 --DSAQDVQAKQVLKGMSDVAQEKNKNQEESIDARAPGGKVRRWDQGLEKPRLDYSEFFT 492
Query: 708 DDIGTEPGIEIWDIDEFYPRKITEEVPVGTFYNGDCYIILHTRQDEKNHNSLIHSIYYWI 887
+D+G PG+ IW I+ F P + EE G FY DCYI+L T D+ SL IYYWI
Sbjct: 493 EDVGQLPGLTIWQIENFVP-VLVEEAFHGKFYEADCYIVLKTFLDDS--GSLNWEIYYWI 549
Query: 888 GNIATLDKVTSAAVHA 935
G ATLDK +A+HA
Sbjct: 550 GGEATLDKKACSAIHA 565
Score = 43.9 bits (102), Expect = 7e-04
Identities = 25/96 (26%), Positives = 46/96 (47%)
Frame = +3
Query: 87 ITRLSKLKKLYVDENNLTFNGIPPGIGKLTNLEVFSASENLLENIPEGLCRCGQLKHLNL 266
++ L L+ + N+L +G+P I KL +L V S N L P L + LNL
Sbjct: 75 LSSLPSLRAIVARANSLKNSGVPDDIFKLDDLSVLDLSHNQLTECpreLENAKNMLVLNL 134
Query: 267 KMNKLVTLPDAINVLIESLKTFNIENNPHLKMPPKL 374
N + ++P+ + + + L ++ N +PP++
Sbjct: 135 SHNGIDSIPNQLFINLTDLLYLDLSENRLESLPPQM 170
Score = 38.1 bits (87), Expect = 0.036
Identities = 25/87 (28%), Positives = 41/87 (47%)
Frame = +3
Query: 105 LKKLYVDENNLTFNGIPPGIGKLTNLEVFSASENLLENIPEGLCRCGQLKHLNLKMNKLV 284
L+ L++ T + +P + L+NL S N L +PE L L+ LNL N++
Sbjct: 200 LQTLHLRNTQRTQSNLPTSLEGLSNLSDVDLSCNDLTRVPECLYTLPSLRRLNLSSNQIA 259
Query: 285 TLPDAINVLIESLKTFNIENNPHLKMP 365
L I+ + L+T N+ N +P
Sbjct: 260 ELSLCIDQWVH-LETLNLSRNQLTSLP 285
>sp|P34268|FLII_CAEEL Flightless-I protein homolog
Length = 1257
Score = 208 bits (530), Expect = 2e-53
Identities = 122/315 (38%), Positives = 186/315 (59%), Gaps = 12/315 (3%)
Frame = +3
Query: 27 WPNLEVXXXXXXXXXXXXXFITRLSKLKKLYVDENNLTFNGIPPGIGKLTNLEVFSASEN 206
W NLE + +L++L KLY N LTF GIP GIGKL L V S N
Sbjct: 267 WENLETLNMSHNQLTVLPDCVVKLTRLTKLYAANNQLTFEGIPSGIGKLIQLTVLHLSYN 326
Query: 207 LLENIPEGLCRCGQLKHLNLKMNKLVTLPDAINVLIESLKTFNIENNPHLKMPPKLEEND 386
LE +PEG+ RC +L+ L L N+L+TLP+ I+ L+ LK ++ N +L MPPK ND
Sbjct: 327 KLELVPEGISRCVKLQKLKLDHNRLITLPEGIH-LLPDLKVLDLHENENLVMPPK--PND 383
Query: 387 SKSKYSFYNIDFSLETQMQLA-RGAPVKTSVQNV----TQKDTASRIRRLRRKKIDEKNE 551
++ K +FYNIDFSLE Q ++A + +S+ +V ++D +R + R++ + ++
Sbjct: 384 ARKKLAFYNIDFSLEHQRKIAGQMTSPSSSISSVHSGGARQDALARRKEFIRRRKQQADQ 443
Query: 552 KSDSKRVLEGMQKVAKDKDAVMEDQEKE-----TIKSAKRWQDAIAK--PNLDYSRVFDD 710
+S K V++GM K+A A+ E Q++E KSA W+ I K ++DYS +FD+
Sbjct: 444 QSADK-VIQGMSKIAGVGAALTEKQQEEEERQLEAKSAVNWKKNIEKNRRHIDYSDIFDE 502
Query: 711 DIGTEPGIEIWDIDEFYPRKITEEVPVGTFYNGDCYIILHTRQDEKNHNSLIHSIYYWIG 890
D+G++ G+ +W+I+ FYP I +E G FY+ D Y++L T ++ L H+I+YW+G
Sbjct: 503 DVGSDEGMWVWEIENFYP-SIMDEAFHGQFYDADAYLVLKTTREAS--GQLRHAIFYWLG 559
Query: 891 NIATLDKVTSAAVHA 935
A+LDK +AVHA
Sbjct: 560 EHASLDKGMCSAVHA 574
Score = 48.9 bits (115), Expect = 2e-05
Identities = 27/96 (28%), Positives = 49/96 (51%)
Frame = +3
Query: 87 ITRLSKLKKLYVDENNLTFNGIPPGIGKLTNLEVFSASENLLENIPEGLCRCGQLKHLNL 266
++ L +L+ + V +NNL GIP I ++ +L + S N L +P L LNL
Sbjct: 74 LSDLPRLRSVIVRDNNLKTAGIPTDIFRMKDLTIIDLSRNQLREVPTNLEYAKGSIVLNL 133
Query: 267 KMNKLVTLPDAINVLIESLKTFNIENNPHLKMPPKL 374
N + T+P+++ + L ++ NN +PP++
Sbjct: 134 SYNNIETIPNSVCANLIDLLFLDLSNNKLDMLPPQI 169
Score = 47.0 bits (110), Expect = 8e-05
Identities = 29/90 (32%), Positives = 46/90 (51%)
Frame = +3
Query: 96 LSKLKKLYVDENNLTFNGIPPGIGKLTNLEVFSASENLLENIPEGLCRCGQLKHLNLKMN 275
++ L L++ N T + IPP + + NL SEN L +PE L + L+ LNL N
Sbjct: 196 MTSLSVLHMSNTNRTLDNIPPTLDDMHNLRDVDFSENNLPIVPEALFKLRNLRKLNLSGN 255
Query: 276 KLVTLPDAINVLIESLKTFNIENNPHLKMP 365
K+ L + E+L+T N+ +N +P
Sbjct: 256 KIEKL-NMTEGEWENLETLNMSHNQLTVLP 284
Score = 37.7 bits (86), Expect = 0.047
Identities = 19/84 (22%), Positives = 42/84 (50%)
Frame = +3
Query: 96 LSKLKKLYVDENNLTFNGIPPGIGKLTNLEVFSASENLLENIPEGLCRCGQLKHLNLKMN 275
L +K + N+ + + P + ++T + +++ LE +P+ L RC L+HL + N
Sbjct: 6 LQFVKGIDFSGNDFSGDRFPHDVEQMTQMTWLKLNDSKLEQVPDELSRCANLEHLQMAHN 65
Query: 276 KLVTLPDAINVLIESLKTFNIENN 347
+L+++ ++ L +NN
Sbjct: 66 QLISVHGELSDLPRLRSVIVRDNN 89
>sp|Q6UWE0|LRSM1_HUMAN Ubiquitin ligase protein LRSAM1 (Leucine-rich repeat and sterile
alpha motif containing 1) (Tsg101-associated ligase)
(hTAL)
Length = 723
Score = 58.5 bits (140), Expect = 3e-08
Identities = 35/93 (37%), Positives = 52/93 (55%)
Frame = +3
Query: 96 LSKLKKLYVDENNLTFNGIPPGIGKLTNLEVFSASENLLENIPEGLCRCGQLKHLNLKMN 275
L+ +K L + +N LT +P +G+LT L+V + N L +P + QL+ LN+K N
Sbjct: 80 LATIKVLDLHDNQLT--ALPDDLGQLTALQVLNVERNQLMQLPRSIGNLTQLQTLNVKDN 137
Query: 276 KLVTLPDAINVLIESLKTFNIENNPHLKMPPKL 374
KL LPD + L SL+T NI N ++P L
Sbjct: 138 KLKELPDTVGEL-RSLRTLNISGNEIQRLPQML 169
>sp|Q96RT1|LAP2_HUMAN LAP2 protein (Erbb2-interacting protein) (Erbin) (Densin-180-like
protein)
Length = 1412
Score = 57.0 bits (136), Expect = 7e-08
Identities = 34/96 (35%), Positives = 52/96 (54%)
Frame = +3
Query: 87 ITRLSKLKKLYVDENNLTFNGIPPGIGKLTNLEVFSASENLLENIPEGLCRCGQLKHLNL 266
+ +LS LK+ ++D N LTF IP IG L L S+N +E + EG+ C L+ L L
Sbjct: 203 LEQLSGLKEFWMDANRLTF--IPGFIGSLKQLTYLDVSKNNIEMVEEGISTCENLQDLLL 260
Query: 267 KMNKLVTLPDAINVLIESLKTFNIENNPHLKMPPKL 374
N L LP+ I L +++ T I+ N + +P +
Sbjct: 261 SSNSLQQLPETIGSL-KNITTLKIDENQLMYLPDSI 295
Score = 48.5 bits (114), Expect = 3e-05
Identities = 29/85 (34%), Positives = 46/85 (54%), Gaps = 3/85 (3%)
Frame = +3
Query: 120 VDENNLTFN---GIPPGIGKLTNLEVFSASENLLENIPEGLCRCGQLKHLNLKMNKLVTL 290
V+E + +FN +P IG+LTNL F+A N L+ +P + + L L NKL TL
Sbjct: 301 VEELDCSFNEVEALPSSIGQLTNLRTFAADHNYLQQLPPEIGSWKNITVLFLHSNKLETL 360
Query: 291 PDAINVLIESLKTFNIENNPHLKMP 365
P+ + + + LK N+ +N +P
Sbjct: 361 PEEMGDM-QKLKVINLSDNRLKNLP 384
Score = 46.2 bits (108), Expect = 1e-04
Identities = 32/104 (30%), Positives = 51/104 (49%)
Frame = +3
Query: 87 ITRLSKLKKLYVDENNLTFNGIPPGIGKLTNLEVFSASENLLENIPEGLCRCGQLKHLNL 266
I +L+ L+ D N L +PP IG N+ V N LE +PE + +LK +NL
Sbjct: 318 IGQLTNLRTFAADHNYL--QQLPPEIGSWKNITVLFLHSNKLETLPEEMGDMQKLKVINL 375
Query: 267 KMNKLVTLPDAINVLIESLKTFNIENNPHLKMPPKLEENDSKSK 398
N+L LP + L + L + +N + P +E DS+++
Sbjct: 376 SDNRLKNLPFSFTKL-QQLTAMWLSDNQSKPLIPLQKETDSETQ 418
Score = 39.3 bits (90), Expect = 0.016
Identities = 22/70 (31%), Positives = 35/70 (50%)
Frame = +3
Query: 105 LKKLYVDENNLTFNGIPPGIGKLTNLEVFSASENLLENIPEGLCRCGQLKHLNLKMNKLV 284
L KL + +N+LT +P I L NL S+N ++ PE + C L + +N +
Sbjct: 71 LHKLSLPDNDLTT--LPASIANLINLRELDVSKNGIQEFPENIKNCKVLTIVEASVNPIS 128
Query: 285 TLPDAINVLI 314
LPD + L+
Sbjct: 129 KLPDGFSQLL 138
Score = 35.8 bits (81), Expect = 0.18
Identities = 24/73 (32%), Positives = 35/73 (47%)
Frame = +3
Query: 93 RLSKLKKLYVDENNLTFNGIPPGIGKLTNLEVFSASENLLENIPEGLCRCGQLKHLNLKM 272
RL+KL+ L + EN L +P + +LT LE N +PE L + LK +
Sbjct: 159 RLTKLQILELRENQLKM--LPKTMNRLTQLERLDLGSNEFTEVPEVLEQLSGLKEFWMDA 216
Query: 273 NKLVTLPDAINVL 311
N+L +P I L
Sbjct: 217 NRLTFIPGFIGSL 229
>sp|P10733|SEVE_DICDI Severin
Length = 362
Score = 56.6 bits (135), Expect = 1e-07
Identities = 30/71 (42%), Positives = 42/71 (59%)
Frame = +3
Query: 714 IGTEPGIEIWDIDEFYPRKITEEVPVGTFYNGDCYIILHTRQDEKNHNSLIHSIYYWIGN 893
+G PG++IW I+ F + E G FY+GD YIILHT K NSL H I++++G
Sbjct: 39 VGQAPGLKIWRIENFKVVPVPES-SYGKFYDGDSYIILHT---FKEGNSLKHDIHFFLGT 94
Query: 894 IATLDKVTSAA 926
T D+ +AA
Sbjct: 95 FTTQDEAGTAA 105
>sp|Q9V780|LAP1_DROME Lap1 protein
Length = 849
Score = 56.6 bits (135), Expect = 1e-07
Identities = 31/70 (44%), Positives = 40/70 (57%)
Frame = +3
Query: 105 LKKLYVDENNLTFNGIPPGIGKLTNLEVFSASENLLENIPEGLCRCGQLKHLNLKMNKLV 284
L+ L+V+ NNL IP IG L L+ + NL+ N+PE + C L HL+L N L
Sbjct: 65 LRVLHVNSNNL--ESIPQAIGSLRQLQHLDLNRNLIVNVPEEIKSCKHLTHLDLSCNSLQ 122
Query: 285 TLPDAINVLI 314
LPDAI LI
Sbjct: 123 RLPDAITSLI 132
Score = 53.1 bits (126), Expect = 1e-06
Identities = 39/129 (30%), Positives = 60/129 (46%), Gaps = 11/129 (8%)
Frame = +3
Query: 87 ITRLSKLKKLYVDENNLTFNGIPPGIGKLTNLEVFSASENLLENIPEGLCRCGQLKHLNL 266
I+ L +L++L + N L +P IG L +L A +N L +P+ LC C QL L++
Sbjct: 289 ISYLEQLEELVLSHNKLI--RLPSTIGMLRSLRFLFADDNQLRQLPDELCSCQQLSVLSV 346
Query: 267 KMNKLVTLPDAINVLIESLKTFNIENNPHLKMPPK-----------LEENDSKSKYSFYN 413
N+L LP I L +K N+ NN +P L +N S+
Sbjct: 347 ANNQLSALPQNIGNL-SKMKVLNVVNNYINALPVSMLNLVNLTSMWLSDNQSQPLVPLQY 405
Query: 414 IDFSLETQM 440
+D S +TQ+
Sbjct: 406 LDASTKTQL 414
Score = 49.3 bits (116), Expect = 2e-05
Identities = 29/96 (30%), Positives = 53/96 (55%)
Frame = +3
Query: 87 ITRLSKLKKLYVDENNLTFNGIPPGIGKLTNLEVFSASENLLENIPEGLCRCGQLKHLNL 266
+ L L++L++D N + + IGKL +L+ F A+ NLL+ +P L ++ L++
Sbjct: 197 VGELKSLRELWIDFNQI--RRVSANIGKLRDLQHFEANGNLLDTLPSELSNWRNVEVLSI 254
Query: 267 KMNKLVTLPDAINVLIESLKTFNIENNPHLKMPPKL 374
N L P ++ +L +SL TF E+N ++P +
Sbjct: 255 CSNSLEAFPFSVGML-KSLVTFKCESNGLTELPDSI 289
Score = 41.2 bits (95), Expect = 0.004
Identities = 22/66 (33%), Positives = 36/66 (54%)
Frame = +3
Query: 105 LKKLYVDENNLTFNGIPPGIGKLTNLEVFSASENLLENIPEGLCRCGQLKHLNLKMNKLV 284
L++LY+ L +PP + L V + N LE+IP+ + QL+HL+L N +V
Sbjct: 42 LEELYLSTTRL--QALPPQLFYCQGLRVLHVNSNNLESIPQAIGSLRQLQHLDLNRNLIV 99
Query: 285 TLPDAI 302
+P+ I
Sbjct: 100 NVPEEI 105
>sp|Q01730|RSU1_MOUSE Ras suppressor protein 1 (Rsu-1) (RSP-1)
Length = 277
Score = 56.2 bits (134), Expect = 1e-07
Identities = 32/87 (36%), Positives = 51/87 (58%), Gaps = 2/87 (2%)
Frame = +3
Query: 96 LSKLKKLYVDENNLTFNGIPPGIGKLTNLEVFSASENLLENIPEGLCRCGQLKHLNLKMN 275
L+ L+ LY+ +N+ F +PP IGKLT L++ S +N L ++P+ + QLK L+++ N
Sbjct: 133 LTTLRALYLSDND--FEILPPDIGKLTKLQILSLRDNDLISLPKEIGELTQLKELHIQGN 190
Query: 276 KLVTLPDAIN--VLIESLKTFNIENNP 350
+L LP + L + F ENNP
Sbjct: 191 RLTVLPPELGNLDLTGQKQVFKAENNP 217
Score = 52.4 bits (124), Expect = 2e-06
Identities = 27/66 (40%), Positives = 40/66 (60%)
Frame = +3
Query: 96 LSKLKKLYVDENNLTFNGIPPGIGKLTNLEVFSASENLLENIPEGLCRCGQLKHLNLKMN 275
L+ + +L + N LT +PP + +L NLEV + N +E +P + +LKHLNL MN
Sbjct: 39 LAHITQLVLSHNKLTT--VPPNVAELKNLEVLNFFNNQIEELPTQISSLQKLKHLNLGMN 96
Query: 276 KLVTLP 293
+L TLP
Sbjct: 97 RLNTLP 102
Score = 45.8 bits (107), Expect = 2e-04
Identities = 30/94 (31%), Positives = 49/94 (52%)
Frame = +3
Query: 105 LKKLYVDENNLTFNGIPPGIGKLTNLEVFSASENLLENIPEGLCRCGQLKHLNLKMNKLV 284
L+ L + NNL + +P LT L S+N E +P + + +L+ L+L+ N L+
Sbjct: 111 LEVLELTYNNLNEHSLPGNFFYLTTLRALYLSDNDFEILPPDIGKLTKLQILSLRDNDLI 170
Query: 285 TLPDAINVLIESLKTFNIENNPHLKMPPKLEEND 386
+LP I L + LK +I+ N +PP+L D
Sbjct: 171 SLPKEIGELTQ-LKELHIQGNRLTVLPPELGNLD 203
>sp|Q15404|RSU1_HUMAN Ras suppressor protein 1 (Rsu-1) (RSP-1)
Length = 277
Score = 56.2 bits (134), Expect = 1e-07
Identities = 32/87 (36%), Positives = 51/87 (58%), Gaps = 2/87 (2%)
Frame = +3
Query: 96 LSKLKKLYVDENNLTFNGIPPGIGKLTNLEVFSASENLLENIPEGLCRCGQLKHLNLKMN 275
L+ L+ LY+ +N+ F +PP IGKLT L++ S +N L ++P+ + QLK L+++ N
Sbjct: 133 LTTLRALYLSDND--FEILPPDIGKLTKLQILSLRDNDLISLPKEIGELTQLKELHIQGN 190
Query: 276 KLVTLPDAIN--VLIESLKTFNIENNP 350
+L LP + L + F ENNP
Sbjct: 191 RLTVLPPELGNLDLTGQKQVFKAENNP 217
Score = 54.7 bits (130), Expect = 4e-07
Identities = 29/66 (43%), Positives = 40/66 (60%)
Frame = +3
Query: 96 LSKLKKLYVDENNLTFNGIPPGIGKLTNLEVFSASENLLENIPEGLCRCGQLKHLNLKMN 275
LS + +L + N LT +PP I +L NLEV + N +E +P + +LKHLNL MN
Sbjct: 39 LSHITQLVLSHNKLTM--VPPNIAELKNLEVLNFFNNQIEELPTQISSLQKLKHLNLGMN 96
Query: 276 KLVTLP 293
+L TLP
Sbjct: 97 RLNTLP 102
Score = 48.5 bits (114), Expect = 3e-05
Identities = 32/97 (32%), Positives = 51/97 (52%)
Frame = +3
Query: 96 LSKLKKLYVDENNLTFNGIPPGIGKLTNLEVFSASENLLENIPEGLCRCGQLKHLNLKMN 275
L L+ L + NNL+ N +P LT L S+N E +P + + +L+ L+L+ N
Sbjct: 108 LPALEVLDLTYNNLSENSLPGNFFYLTTLRALYLSDNDFEILPPDIGKLTKLQILSLRDN 167
Query: 276 KLVTLPDAINVLIESLKTFNIENNPHLKMPPKLEEND 386
L++LP I L + LK +I+ N +PP+L D
Sbjct: 168 DLISLPKEIGELTQ-LKELHIQGNRLTVLPPELGNLD 203
Database: Non-redundant SwissProt sequences
Posted date: Dec 6, 2005 7:40 AM
Number of letters in database: 68,354,980
Number of sequences in database: 184,735
Database: swissprot.01
Posted date: Dec 6, 2005 8:18 AM
Number of letters in database: 66,202,850
Number of sequences in database: 184,431
Lambda K H
0.318 0.134 0.401
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 94,319,483
Number of Sequences: 369166
Number of extensions: 1810851
Number of successful extensions: 6664
Number of sequences better than 10.0: 10
Number of HSP's better than 10.0 without gapping: 5884
Number of HSP's successfully gapped in prelim test: 0
Number of HSP's that attempted gapping in prelim test: 0
Number of HSP's gapped (non-prelim): 6551
length of database: 68,354,980
effective HSP length: 110
effective length of database: 48,034,130
effective search space used: 9654860130
frameshift window, decay const: 40, 0.1
T: 12
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)