Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= Dr_sW_006_F17
(894 letters)
Database: Non-redundant SwissProt sequences
184,735 sequences; 68,354,980 total letters
Score E
Sequences producing significant alignments: (bits) Value
sp|Q16222|UAP1_HUMAN UDP-N-acetylhexosamine pyrophosphoryla... 275 2e-73
sp|Q91YN5|UAP1_MOUSE UDP-N-acetylhexosamine pyrophosphoryla... 270 3e-72
sp|O64765|UAP1_ARATH Probable UDP-N-acetylglucosamine pyrop... 235 1e-61
sp|O74933|UAP1_CANAL UDP-N-acetylglucosamine pyrophosphorylase 229 8e-60
sp|P43123|UAP1_YEAST UDP-N-acetylglucosamine pyrophosphorylase 224 2e-58
sp|O94617|UAP1_SCHPO Probable UDP-N-acetylglucosamine pyrop... 202 1e-51
sp|Q18493|UAP1_CAEEL Probable UDP-N-acetylglucosamine pyrop... 186 1e-46
sp|P78811|UGPA1_SCHPO Probable UTP--glucose-1-phosphate uri... 42 0.003
sp|Q9LKG7|UGPA_ASTME UTP--glucose-1-phosphate uridylyltrans... 42 0.003
sp|Q43772|UGPA_HORVU UTP--glucose-1-phosphate uridylyltrans... 41 0.004
>sp|Q16222|UAP1_HUMAN UDP-N-acetylhexosamine pyrophosphorylase (Antigen X) (AGX)
(Sperm-associated antigen 2) [Includes:
UDP-N-acetylgalactosamine pyrophosphorylase (AGX-1);
UDP-N-acetylglucosamine pyrophosphorylase (AGX-2)]
Length = 522
Score = 275 bits (702), Expect = 2e-73
Identities = 146/279 (52%), Positives = 188/279 (67%), Gaps = 1/279 (0%)
Frame = +1
Query: 19 YGKTAPISWYIMTSDCTADATMEYFKDNNYFGLSPDQIIFFEQFTLPVVGCNGKIILETK 198
YG I WYIMTS T ++T E+F + YFGL + +IFF+Q LP + +GKIILE K
Sbjct: 154 YGNKCIIPWYIMTSGRTMESTKEFFTKHKYFGLKKENVIFFQQGMLPAMSFDGKIILEEK 213
Query: 199 CKISKSPDGNGGLYRALYNYKLVDDMKSRGIKYALVYGVDNILVKIVDPVFLGFCVEKGA 378
K+S +PDGNGGLYRAL +V+DM+ RGI VY VDNILVK+ DP F+GFC++KGA
Sbjct: 214 NKVSMAPDGNGGLYRALAAQNIVEDMEQRGIWSIHVYCVDNILVKVADPRFIGFCIQKGA 273
Query: 379 ECAAKVVEKVHPKEAVGIVGKVNGCYQVIEYSEISLETATMRDIKNDKLLYRCGSICTHL 558
+C AKVVEK +P E VG+V +V+G YQV+EYSEISL TA R + +LL+ G+I H
Sbjct: 274 DCGAKVVEKTNPTEPVGVVCRVDGVYQVVEYSEISLATAQKRS-SDGRLLFNAGNIANHF 332
Query: 559 FSVDFLSRFCQNNVNNLLLQHIAIKKVPFINIQTGILEIPEKENAIKMEKFVFDVFPLAK 738
F+V FL R N L H+A KK+P+++ Q G L P+K N IKMEKFVFD+F AK
Sbjct: 333 FTVPFL-RDVVNVYEPQLQHHVAQKKIPYVDTQ-GQLIKPDKPNGIKMEKFVFDIFQFAK 390
Query: 739 TFAIWEVERNREFSALKNAPGSQ-SDCPETAKNDLLAYH 852
F ++EV R EFS LKNA D P TA++ L++ H
Sbjct: 391 KFVVYEVLREDEFSPLKNADSQNGKDNPTTARHALMSLH 429
>sp|Q91YN5|UAP1_MOUSE UDP-N-acetylhexosamine pyrophosphorylase [Includes:
UDP-N-acetylgalactosamine pyrophosphorylase ;
UDP-N-acetylglucosamine pyrophosphorylase ]
Length = 522
Score = 270 bits (691), Expect = 3e-72
Identities = 143/284 (50%), Positives = 189/284 (66%), Gaps = 1/284 (0%)
Frame = +1
Query: 4 LALMKYGKTAPISWYIMTSDCTADATMEYFKDNNYFGLSPDQIIFFEQFTLPVVGCNGKI 183
LA +G I WYIMTS T ++T E+F + +FGL + ++FF+Q LP + +GKI
Sbjct: 149 LAEKHHGNKCTIPWYIMTSGRTMESTKEFFTKHKFFGLKKENVVFFQQGMLPAMSFDGKI 208
Query: 184 ILETKCKISKSPDGNGGLYRALYNYKLVDDMKSRGIKYALVYGVDNILVKIVDPVFLGFC 363
ILE K K+S +PDGNGGLYRAL +V+DM+ RGI VY VDNILVK+ DP F+GFC
Sbjct: 209 ILEEKNKVSMAPDGNGGLYRALAAQNIVEDMEQRGICSIHVYCVDNILVKVADPRFIGFC 268
Query: 364 VEKGAECAAKVVEKVHPKEAVGIVGKVNGCYQVIEYSEISLETATMRDIKNDKLLYRCGS 543
++KGA+C AKVVEK +P E VG+V +V+G YQV+EYSEISL TA R + +LL+ G+
Sbjct: 269 IQKGADCGAKVVEKTNPTEPVGVVCRVDGVYQVVEYSEISLATAQRRS-SDGRLLFNAGN 327
Query: 544 ICTHLFSVDFLSRFCQNNVNNLLLQHIAIKKVPFINIQTGILEIPEKENAIKMEKFVFDV 723
I H F+V FL + N L H+A KK+P+++ Q G P+K N IKMEKFVFD+
Sbjct: 328 IANHFFTVPFL-KDVVNVYEPQLQHHVAQKKIPYVDSQ-GYFIKPDKPNGIKMEKFVFDI 385
Query: 724 FPLAKTFAIWEVERNREFSALKNAPGSQ-SDCPETAKNDLLAYH 852
F AK F ++EV R EFS LKNA D P TA++ L++ H
Sbjct: 386 FQFAKKFVVYEVLREDEFSPLKNADSQNGKDNPTTARHALMSLH 429
>sp|O64765|UAP1_ARATH Probable UDP-N-acetylglucosamine pyrophosphorylase
Length = 502
Score = 235 bits (599), Expect = 1e-61
Identities = 124/287 (43%), Positives = 183/287 (63%), Gaps = 5/287 (1%)
Frame = +1
Query: 7 ALMKYGKTAPIS--WYIMTSDCTADATMEYFKDNNYFGLSPDQIIFFEQFTLPVVGCNGK 180
A+ + T P++ WYIMTS T + T ++FK + YFGL PDQ+ FF+Q TLP + +GK
Sbjct: 175 AMSEASPTRPVTIQWYIMTSPFTHEPTQKFFKSHKYFGLEPDQVTFFQQGTLPCISKDGK 234
Query: 181 IILETKCKISKSPDGNGGLYRALYNYKLVDDMKSRGIKYALVYGVDNILVKIVDPVFLGF 360
I+ET +SK+PDGNGG+Y AL + +L++DM SRGIKY YGVDN+LV++ DP FLG+
Sbjct: 235 FIMETPFSLSKAPDGNGGVYTALKSSRLLEDMASRGIKYVDCYGVDNVLVRVADPTFLGY 294
Query: 361 CVEKGAECAAKVVEKVHPKEAVGIV---GKVNGCYQVIEYSEISLETATMRDIKNDKLLY 531
++K A AAKVV K +P+E VG+ GK G V+EY+E+ A+ + + +L Y
Sbjct: 295 FIDKSAASAAKVVRKAYPQEKVGVFVRRGK-GGPLTVVEYTELDQSMASATNQQTGRLQY 353
Query: 532 RCGSICTHLFSVDFLSRFCQNNVNNLLLQHIAIKKVPFINIQTGILEIPEKENAIKMEKF 711
++C H+F++DFL++ N + + H+A KK+P IN +K+E+F
Sbjct: 354 CWSNVCLHMFTLDFLNQVA-NGLEKDSVYHLAEKKIPSINGDI---------VGLKLEQF 403
Query: 712 VFDVFPLAKTFAIWEVERNREFSALKNAPGSQSDCPETAKNDLLAYH 852
+FD FP A + A++EV R EF+ +KNA GS D PE+A+ +L H
Sbjct: 404 IFDCFPYAPSTALFEVLREEEFAPVKNANGSNYDTPESARLLVLRLH 450
>sp|O74933|UAP1_CANAL UDP-N-acetylglucosamine pyrophosphorylase
Length = 486
Score = 229 bits (584), Expect = 8e-60
Identities = 130/285 (45%), Positives = 182/285 (63%), Gaps = 8/285 (2%)
Frame = +1
Query: 13 MKYGKTAPISWYIMTSDCTADATMEYFKDNNYFGLSPDQIIFFEQFTLPVVGCNG-KIIL 189
+K K I+WYIMTS T +AT +F +NNYFGL+ Q+IFF Q TLP G KI+L
Sbjct: 155 LKSTKKPIINWYIMTSGPTRNATESFFIENNYFGLNSHQVIFFNQGTLPCFNLQGNKILL 214
Query: 190 ETKCKISKSPDGNGGLYRALYNYKLVDDMKSRGIKYALVYGVDNILVKIVDPVFLGFCVE 369
E+K I +SPDGNGGLY+AL + ++DD+ S+GIK+ +Y VDN LVK+ DP+F+GF +
Sbjct: 215 ESKNSICQSPDGNGGLYKALKDNGILDDLNSKGIKHIHMYCVDNCLVKVADPIFIGFAIA 274
Query: 370 KGAECAAKVVEKVHPKEAVGIV--GKVNGCYQVIEYSEISLETATMRDIK-NDKLLYRCG 540
K + A KVV K E+VG++ + N VIEYSEIS E A +D + + KL R
Sbjct: 275 KKFDLATKVVRKRDANESVGLIVLDQDNQKPCVIEYSEISQELANKKDPQDSSKLFLRAA 334
Query: 541 SICTHLFSVDFLSRFCQNNVNN--LLLQHIAIKKVPFINIQTGILEIPEKENAIKMEKFV 714
+I H +SV+FL++ +++ L HIA KK+P +N++ G P + N IK+E+F+
Sbjct: 335 NIVNHYYSVEFLNKMIPKWISSQKYLPFHIAKKKIPSLNLENGEFYKPTEPNGIKLEQFI 394
Query: 715 FDVFPLAK--TFAIWEVERNREFSALKNAPGSQSDCPETAKNDLL 843
FDVFP + F EV+R EFS LKNA G+++D P T +N L
Sbjct: 395 FDVFPSVELNKFGCLEVDRLDEFSPLKNADGAKNDTPTTCRNHYL 439
>sp|P43123|UAP1_YEAST UDP-N-acetylglucosamine pyrophosphorylase
Length = 477
Score = 224 bits (572), Expect = 2e-58
Identities = 134/283 (47%), Positives = 174/283 (61%), Gaps = 8/283 (2%)
Frame = +1
Query: 25 KTAPISWYIMTSDCTADATMEYFKDNNYFGLSPDQIIFFEQFTLPVVGCNGK-IILETKC 201
K I WYIMTS T AT YF+++NYFGL+ +QI FF Q TLP GK +++
Sbjct: 154 KKVEIPWYIMTSGPTRAATEAYFQEHNYFGLNKEQITFFNQGTLPAFDLTGKHFLMKDPV 213
Query: 202 KISKSPDGNGGLYRALYNYKLVDDMKSRGIKYALVYGVDNILVKIVDPVFLGFCVEKGAE 381
+S+SPDGNGGLYRA+ KL +D RGIK+ +Y VDN+L KI DPVF+GF ++ G E
Sbjct: 214 NLSQSPDGNGGLYRAIKENKLNEDFDRRGIKHVYMYCVDNVLSKIADPVFIGFAIKHGFE 273
Query: 382 CAAKVVEKVHPKEAVGIVGKVNGCYQVIEYSEISLETATMRDIKNDKLLYRCGSICTHLF 561
A K V K E+VG++ N VIEYSEIS E A +D K+ L R G+I H +
Sbjct: 274 LATKAVRKRDAHESVGLIATKNEKPCVIEYSEISNELAEAKD-KDGLLKLRAGNIVNHYY 332
Query: 562 SVDFLSR----FCQNNVNNLLLQHIAIKKVPFINIQTGILEIPEKENAIKMEKFVFDVF- 726
VD L R +C+N + HIA KK+P + TG P + N IK+E+F+FDVF
Sbjct: 333 LVDLLKRDLDQWCEN-----MPYHIAKKKIPAYDSVTGKYTKPTEPNGIKLEQFIFDVFD 387
Query: 727 --PLAKTFAIWEVERNREFSALKNAPGSQSDCPETAKNDLLAY 849
PL K F EV+R +EFS LKN PGS++D PET++ LAY
Sbjct: 388 TVPLNK-FGCLEVDRCKEFSPLKNGPGSKNDNPETSR---LAY 426
>sp|O94617|UAP1_SCHPO Probable UDP-N-acetylglucosamine pyrophosphorylase
Length = 475
Score = 202 bits (513), Expect = 1e-51
Identities = 108/274 (39%), Positives = 162/274 (59%), Gaps = 4/274 (1%)
Frame = +1
Query: 37 ISWYIMTSDCTADATMEYFKDNNYFGLSPDQIIFFEQFTLPVVGCNGKIILETKCKISKS 216
I WYIM S+CT++ T+ +FK+N++FG+ + FF+Q LP + +G+++ E+ ++ +
Sbjct: 158 IPWYIMVSECTSEETISFFKENDFFGIDKKDVFFFQQGVLPCLDISGRVLFESDSSLAWA 217
Query: 217 PDGNGGLYRALYNYKLVDDMKSRGIKYALVYGVDNILVKIVDPVFLGFCVEKGAECAAKV 396
P+GNGG+Y AL + ++DM RGI + Y VDN+LV VDPVF+G K E A K
Sbjct: 218 PNGNGGIYEALLSSGALNDMNRRGILHITAYSVDNVLVLPVDPVFIGMATTKKLEVATKT 277
Query: 397 VEKVHPKEAVGIVGKVNGCYQVIEYSEISLET--ATMRDIKNDKLLYRCGSICTHLFSVD 570
VEK+ P E VG++ + V+EYSEIS E AT + LL R +I H FS D
Sbjct: 278 VEKIDPAEKVGLLVSSHNHPCVVEYSEISDEACKATENVDGHKHLLLRAANIAYHYFSFD 337
Query: 571 FLSRFCQNNVNNLLLQHIAIKKVPFINIQTGILEIPEKENAIKMEKFVFDVFP--LAKTF 744
FL + + ++ L H+A KK+PF ++ + P N K+E F+FD+FP + F
Sbjct: 338 FLQKASLH--SSTLPIHLACKKIPFYDVTSHHYTTPLNPNGYKLESFIFDLFPSVSVENF 395
Query: 745 AIWEVERNREFSALKNAPGSQSDCPETAKNDLLA 846
++V R FS LKN+ S +D ET ND+L+
Sbjct: 396 GCFQVPRRTSFSPLKNSSKSPNDNHETCVNDILS 429
>sp|Q18493|UAP1_CAEEL Probable UDP-N-acetylglucosamine pyrophosphorylase
Length = 484
Score = 186 bits (471), Expect = 1e-46
Identities = 114/270 (42%), Positives = 157/270 (58%), Gaps = 2/270 (0%)
Frame = +1
Query: 37 ISWYIMTSDCTADATMEYFKD-NNYFGLSPD-QIIFFEQFTLPVVGCNGKIILETKCKIS 210
I W +MTS T +AT E+ K + G D QI F Q + G +L TK +
Sbjct: 162 IHWAVMTSPGTEEATREHVKKLAAHHGFDFDEQITIFSQDEIAAYDEQGNFLLGTKGSVV 221
Query: 211 KSPDGNGGLYRALYNYKLVDDMKSRGIKYALVYGVDNILVKIVDPVFLGFCVEKGAECAA 390
+P+GNGGLY A+ + + ++++GIKY VY VDNIL K+ DP F+GF + A+ A
Sbjct: 222 AAPNGNGGLYSAISAH--LPRLRAKGIKYFHVYCVDNILCKVADPHFIGFAISNEADVAT 279
Query: 391 KVVEKVHPKEAVGIVGKVNGCYQVIEYSEISLETATMRDIKNDKLLYRCGSICTHLFSVD 570
K V K E VG V G +V+EYSE+ E A + + K L+ GSI H F++D
Sbjct: 280 KCVPK-QKGELVGSVCLDRGLPRVVEYSELGAELAEQKT-PDGKYLFGAGSIANHFFTMD 337
Query: 571 FLSRFCQNNVNNLLLQHIAIKKVPFINIQTGILEIPEKENAIKMEKFVFDVFPLAKTFAI 750
F+ R C + ++ L H A KK+ ++N Q I++ PEK N IK+E+F+FDVF L+K F I
Sbjct: 338 FMDRVC--SPSSRLPYHRAHKKISYVNEQGTIVK-PEKPNGIKLEQFIFDVFELSKRFFI 394
Query: 751 WEVERNREFSALKNAPGSQSDCPETAKNDL 840
WEV RN EFS LKNA +DC T + DL
Sbjct: 395 WEVARNEEFSPLKNAQSVGTDCLSTCQRDL 424
>sp|P78811|UGPA1_SCHPO Probable UTP--glucose-1-phosphate uridylyltransferase (UDP-glucose
pyrophosphorylase) (UDPGP) (UGPase)
Length = 506
Score = 41.6 bits (96), Expect = 0.003
Identities = 37/161 (22%), Positives = 68/161 (42%)
Frame = +1
Query: 217 PDGNGGLYRALYNYKLVDDMKSRGIKYALVYGVDNILVKIVDPVFLGFCVEKGAECAAKV 396
P G+G ++ AL N ++D + ++G +Y V +DN L +VD L VE AE ++
Sbjct: 219 PPGHGDVFEALTNSGIIDTLIAQGKEYLFVSNIDN-LGAVVDLNILNHMVETNAEYLMEL 277
Query: 397 VEKVHPKEAVGIVGKVNGCYQVIEYSEISLETATMRDIKNDKLLYRCGSICTHLFSVDFL 576
K G + +G +++E +++ + H+ +
Sbjct: 278 TNKTKADVKGGTLIDYDGNVRLLEIAQVPPQ---------------------HVEEFKSI 316
Query: 577 SRFCQNNVNNLLLQHIAIKKVPFINIQTGILEIPEKENAIK 699
+F N NNL ++K+V +N +EI + IK
Sbjct: 317 KKFKYFNTNNLWFHLPSVKRV--VNNHELSMEIIPNKKTIK 355
>sp|Q9LKG7|UGPA_ASTME UTP--glucose-1-phosphate uridylyltransferase (UDP-glucose
pyrophosphorylase) (UDPGP) (UGPase)
Length = 471
Score = 41.6 bits (96), Expect = 0.003
Identities = 57/236 (24%), Positives = 98/236 (41%), Gaps = 7/236 (2%)
Frame = +1
Query: 16 KYGKTAPISWYIMTSDCTADAT---MEYFKDNNYFGLSPDQIIFFEQFTLPVVGCNGKII 186
KYG P+ +M S T D T +E ++++N +I F Q P + + +
Sbjct: 126 KYGSNVPL--LLMNSFNTHDDTQTIVEKYQNSNI------EIHTFNQSQYPRLVVDDFLP 177
Query: 187 LETKCKISKS---PDGNGGLYRALYNYKLVDDMKSRGIKYALVYGVDNILVKIVDPVFLG 357
L +K + K P G+G ++ +L N +D + S+G +Y V DN L IVD L
Sbjct: 178 LPSKGRTDKDGWYPPGHGSMFPSLSNSGKLDALISQGKEYVFVANSDN-LGAIVDLKILN 236
Query: 358 FCVEKGAECAAKVVEKVHPKEAVGIVGKVNGCYQVIEYSEISLETATMRDIKNDKLLYRC 537
V E +V K G + G Q++E +++ E
Sbjct: 237 HLVAHKNEYCMEVTPKTLADVKGGTLISYEGRVQLLEIAQVPDE---------------- 280
Query: 538 GSICTHLFSVDFLSRFCQNNVNNLLLQHIAIKK-VPFINIQTGILEIPEKENAIKM 702
H+ + +F N NNL + AIK+ V ++ I+ P++ + +K+
Sbjct: 281 -----HVGEFKSIEKFKIFNTNNLWVNLKAIKRLVEADALKMEIIPNPKEVDGVKV 331
>sp|Q43772|UGPA_HORVU UTP--glucose-1-phosphate uridylyltransferase (UDP-glucose
pyrophosphorylase) (UDPGP) (UGPase)
Length = 473
Score = 41.2 bits (95), Expect = 0.004
Identities = 55/233 (23%), Positives = 95/233 (40%), Gaps = 4/233 (1%)
Frame = +1
Query: 16 KYGKTAPISWYIMTSDCTADATMEYFKDNNYFGLSPDQIIFFEQFTLPVVGCNGKIILET 195
KYG + P+ +M S T D T + + + S +I F Q P + + L +
Sbjct: 128 KYGCSVPL--LLMNSFNTHDDTQKIVEK---YSNSNIEIHTFNQSQYPRIVTEDFLPLPS 182
Query: 196 KCKISKS---PDGNGGLYRALYNYKLVDDMKSRGIKYALVYGVDNILVKIVDPVFLGFCV 366
K + K P G+G ++ +L N +D + S+G +Y V DN L IVD L +
Sbjct: 183 KGQTGKDGWYPPGHGDVFPSLNNSGKLDTLLSQGKEYVFVANSDN-LGAIVDIKILNHLI 241
Query: 367 EKGAECAAKVVEKVHPKEAVGIVGKVNGCYQVIEYSEISLETATMRDIKNDKLLYRCGSI 546
E +V K G + G Q++E +++ E
Sbjct: 242 HNQNEYCMEVTPKTLADVKGGTLISYEGRVQLLEIAQVPDE------------------- 282
Query: 547 CTHLFSVDFLSRFCQNNVNNLLLQHIAIKK-VPFINIQTGILEIPEKENAIKM 702
H+ + +F N NNL + AIK+ V ++ I+ P++ + +K+
Sbjct: 283 --HVDEFKSIEKFKIFNTNNLWVNLKAIKRLVDAEALKMEIIPNPKEVDGVKV 333
Database: Non-redundant SwissProt sequences
Posted date: Dec 6, 2005 7:40 AM
Number of letters in database: 68,354,980
Number of sequences in database: 184,735
Database: swissprot.01
Posted date: Dec 6, 2005 8:18 AM
Number of letters in database: 66,202,850
Number of sequences in database: 184,431
Lambda K H
0.318 0.134 0.401
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 97,060,570
Number of Sequences: 369166
Number of extensions: 1914338
Number of successful extensions: 5127
Number of sequences better than 10.0: 10
Number of HSP's better than 10.0 without gapping: 4914
Number of HSP's successfully gapped in prelim test: 0
Number of HSP's that attempted gapping in prelim test: 0
Number of HSP's gapped (non-prelim): 5105
length of database: 68,354,980
effective HSP length: 110
effective length of database: 48,034,130
effective search space used: 8982382310
frameshift window, decay const: 40, 0.1
T: 12
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)