Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= Dr_sW_006_F15
(534 letters)
Database: Non-redundant SwissProt sequences
184,735 sequences; 68,354,980 total letters
Score E
Sequences producing significant alignments: (bits) Value
sp|Q00610|CLH1_HUMAN Clathrin heavy chain 1 (CLH-17) 279 3e-75
sp|P11442|CLH_RAT Clathrin heavy chain 279 3e-75
sp|Q68FD5|CLH_MOUSE Clathrin heavy chain 279 3e-75
sp|P49951|CLH_BOVIN Clathrin heavy chain 279 3e-75
sp|P29742|CLH_DROME Clathrin heavy chain 266 2e-71
sp|P53675|CLH2_HUMAN Clathrin heavy chain 2 (CLH-22) 255 5e-68
sp|P34574|CLH_CAEEL Probable clathrin heavy chain 250 1e-66
sp|P25870|CLH_DICDI Clathrin heavy chain 212 5e-55
sp|Q10161|CLH_SCHPO Probable clathrin heavy chain 189 3e-48
sp|P22137|CLH_YEAST Clathrin heavy chain 166 3e-41
>sp|Q00610|CLH1_HUMAN Clathrin heavy chain 1 (CLH-17)
Length = 1675
Score = 279 bits (714), Expect = 3e-75
Identities = 133/176 (75%), Positives = 156/176 (88%)
Frame = +2
Query: 5 SQLALAQLSEGFIKEAVDSYLKAGDPSQYMKVVEAGKRENNYEDLVRYLQMARKKARETF 184
SQLA AQL +G +KEA+DSY+KA DPS YM+VV+A N+E+LV+YLQMARKKARE++
Sbjct: 1109 SQLAKAQLQKGMVKEAIDSYIKADDPSSYMEVVQAANTSGNWEELVKYLQMARKKARESY 1168
Query: 185 IETELAYACAKTNRLADLEEFISGPNHANVTQVADRCFDEKLYDAAKLLYNNVSNYARLA 364
+ETEL +A AKTNRLA+LEEFI+GPN+A++ QV DRC+DEK+YDAAKLLYNNVSN+ RLA
Sbjct: 1169 VETELIFALAKTNRLAELEEFINGPNNAHIQQVGDRCYDEKMYDAAKLLYNNVSNFGRLA 1228
Query: 365 ITLVHLGEYHAAVDSARKANSTRTWKEVCFACVDNEEFRLAQMSGMHIVVHADELE 532
TLVHLGEY AAVD ARKANSTRTWKEVCFACVD +EFRLAQM G+HIVVHADELE
Sbjct: 1229 STLVHLGEYQAAVDGARKANSTRTWKEVCFACVDGKEFRLAQMCGLHIVVHADELE 1284
>sp|P11442|CLH_RAT Clathrin heavy chain
Length = 1675
Score = 279 bits (714), Expect = 3e-75
Identities = 133/176 (75%), Positives = 156/176 (88%)
Frame = +2
Query: 5 SQLALAQLSEGFIKEAVDSYLKAGDPSQYMKVVEAGKRENNYEDLVRYLQMARKKARETF 184
SQLA AQL +G +KEA+DSY+KA DPS YM+VV+A N+E+LV+YLQMARKKARE++
Sbjct: 1109 SQLAKAQLQKGMVKEAIDSYIKADDPSSYMEVVQAANTSGNWEELVKYLQMARKKARESY 1168
Query: 185 IETELAYACAKTNRLADLEEFISGPNHANVTQVADRCFDEKLYDAAKLLYNNVSNYARLA 364
+ETEL +A AKTNRLA+LEEFI+GPN+A++ QV DRC+DEK+YDAAKLLYNNVSN+ RLA
Sbjct: 1169 VETELIFALAKTNRLAELEEFINGPNNAHIQQVGDRCYDEKMYDAAKLLYNNVSNFGRLA 1228
Query: 365 ITLVHLGEYHAAVDSARKANSTRTWKEVCFACVDNEEFRLAQMSGMHIVVHADELE 532
TLVHLGEY AAVD ARKANSTRTWKEVCFACVD +EFRLAQM G+HIVVHADELE
Sbjct: 1229 STLVHLGEYQAAVDGARKANSTRTWKEVCFACVDGKEFRLAQMCGLHIVVHADELE 1284
>sp|Q68FD5|CLH_MOUSE Clathrin heavy chain
Length = 1675
Score = 279 bits (714), Expect = 3e-75
Identities = 133/176 (75%), Positives = 156/176 (88%)
Frame = +2
Query: 5 SQLALAQLSEGFIKEAVDSYLKAGDPSQYMKVVEAGKRENNYEDLVRYLQMARKKARETF 184
SQLA AQL +G +KEA+DSY+KA DPS YM+VV+A N+E+LV+YLQMARKKARE++
Sbjct: 1109 SQLAKAQLQKGMVKEAIDSYIKADDPSSYMEVVQAANASGNWEELVKYLQMARKKARESY 1168
Query: 185 IETELAYACAKTNRLADLEEFISGPNHANVTQVADRCFDEKLYDAAKLLYNNVSNYARLA 364
+ETEL +A AKTNRLA+LEEFI+GPN+A++ QV DRC+DEK+YDAAKLLYNNVSN+ RLA
Sbjct: 1169 VETELIFALAKTNRLAELEEFINGPNNAHIQQVGDRCYDEKMYDAAKLLYNNVSNFGRLA 1228
Query: 365 ITLVHLGEYHAAVDSARKANSTRTWKEVCFACVDNEEFRLAQMSGMHIVVHADELE 532
TLVHLGEY AAVD ARKANSTRTWKEVCFACVD +EFRLAQM G+HIVVHADELE
Sbjct: 1229 STLVHLGEYQAAVDGARKANSTRTWKEVCFACVDGKEFRLAQMCGLHIVVHADELE 1284
>sp|P49951|CLH_BOVIN Clathrin heavy chain
Length = 1675
Score = 279 bits (714), Expect = 3e-75
Identities = 133/176 (75%), Positives = 156/176 (88%)
Frame = +2
Query: 5 SQLALAQLSEGFIKEAVDSYLKAGDPSQYMKVVEAGKRENNYEDLVRYLQMARKKARETF 184
SQLA AQL +G +KEA+DSY+KA DPS YM+VV+A N+E+LV+YLQMARKKARE++
Sbjct: 1109 SQLAKAQLQKGMVKEAIDSYIKADDPSSYMEVVQAANTSGNWEELVKYLQMARKKARESY 1168
Query: 185 IETELAYACAKTNRLADLEEFISGPNHANVTQVADRCFDEKLYDAAKLLYNNVSNYARLA 364
+ETEL +A AKTNRLA+LEEFI+GPN+A++ QV DRC+DEK+YDAAKLLYNNVSN+ RLA
Sbjct: 1169 VETELIFALAKTNRLAELEEFINGPNNAHIQQVGDRCYDEKMYDAAKLLYNNVSNFGRLA 1228
Query: 365 ITLVHLGEYHAAVDSARKANSTRTWKEVCFACVDNEEFRLAQMSGMHIVVHADELE 532
TLVHLGEY AAVD ARKANSTRTWKEVCFACVD +EFRLAQM G+HIVVHADELE
Sbjct: 1229 STLVHLGEYQAAVDGARKANSTRTWKEVCFACVDGKEFRLAQMCGLHIVVHADELE 1284
>sp|P29742|CLH_DROME Clathrin heavy chain
Length = 1678
Score = 266 bits (680), Expect = 2e-71
Identities = 128/176 (72%), Positives = 153/176 (86%)
Frame = +2
Query: 5 SQLALAQLSEGFIKEAVDSYLKAGDPSQYMKVVEAGKRENNYEDLVRYLQMARKKARETF 184
SQLA AQL +G +KEA+DSY+KA DPS Y+ VV+ + +++DLVRYLQMARKKARE++
Sbjct: 1110 SQLAKAQLQQGLVKEAIDSYIKADDPSAYVDVVDVASKVESWDDLVRYLQMARKKARESY 1169
Query: 185 IETELAYACAKTNRLADLEEFISGPNHANVTQVADRCFDEKLYDAAKLLYNNVSNYARLA 364
IE+EL YA A+T RLADLEEFISGPNHA++ ++ +RCF + +YDAAKLLYNNVSN+ARLA
Sbjct: 1170 IESELIYAYARTGRLADLEEFISGPNHADIQKIGNRCFSDGMYDAAKLLYNNVSNFARLA 1229
Query: 365 ITLVHLGEYHAAVDSARKANSTRTWKEVCFACVDNEEFRLAQMSGMHIVVHADELE 532
ITLV+L E+ AVDSARKANSTRTWKEVCFACVD EEFRLAQM G+HIVVHADELE
Sbjct: 1230 ITLVYLKEFQGAVDSARKANSTRTWKEVCFACVDAEEFRLAQMCGLHIVVHADELE 1285
>sp|P53675|CLH2_HUMAN Clathrin heavy chain 2 (CLH-22)
Length = 1640
Score = 255 bits (651), Expect = 5e-68
Identities = 116/176 (65%), Positives = 155/176 (88%)
Frame = +2
Query: 5 SQLALAQLSEGFIKEAVDSYLKAGDPSQYMKVVEAGKRENNYEDLVRYLQMARKKARETF 184
SQLA AQL + +KEA++SY++ DPS Y++VV++ R NN+EDLV++LQMARKK RE++
Sbjct: 1109 SQLAQAQLQKDLVKEAINSYIRGDDPSSYLEVVQSASRSNNWEDLVKFLQMARKKGRESY 1168
Query: 185 IETELAYACAKTNRLADLEEFISGPNHANVTQVADRCFDEKLYDAAKLLYNNVSNYARLA 364
IETEL +A AKT+R+++LE+FI+GPN+A++ QV DRC++E +Y+AAKLLY+NVSN+ARLA
Sbjct: 1169 IETELIFALAKTSRVSELEDFINGPNNAHIQQVGDRCYEEGMYEAAKLLYSNVSNFARLA 1228
Query: 365 ITLVHLGEYHAAVDSARKANSTRTWKEVCFACVDNEEFRLAQMSGMHIVVHADELE 532
TLVHLGEY AAVD++RKA+STRTWKEVCFAC+D +EFR AQ+ G+HIV+HADELE
Sbjct: 1229 STLVHLGEYQAAVDNSRKASSTRTWKEVCFACMDGQEFRFAQLCGLHIVIHADELE 1284
Score = 29.6 bits (65), Expect = 4.8
Identities = 15/73 (20%), Positives = 33/73 (45%), Gaps = 1/73 (1%)
Frame = +2
Query: 242 EFISGPNHANVTQVADRCFDEKLYDAAKLLYNNVS-NYARLAITLVHLGEYHAAVDSARK 418
E+IS ++ + +A LY+ A +++ N + + + + H+G A + A +
Sbjct: 1042 EYISRLDNYDALDIASIAVSSALYEEAFTVFHKFDMNASAIQVLIEHIGNLDRAYEFAER 1101
Query: 419 ANSTRTWKEVCFA 457
N W ++ A
Sbjct: 1102 CNEPAVWSQLAQA 1114
>sp|P34574|CLH_CAEEL Probable clathrin heavy chain
Length = 1681
Score = 250 bits (639), Expect = 1e-66
Identities = 116/176 (65%), Positives = 148/176 (84%)
Frame = +2
Query: 5 SQLALAQLSEGFIKEAVDSYLKAGDPSQYMKVVEAGKRENNYEDLVRYLQMARKKARETF 184
+ LA AQL + +KEAVDS++KA DP YM+VV + ++EDLVRYLQMARKK+RE++
Sbjct: 1111 ASLAKAQLQQNLVKEAVDSFIKADDPGAYMEVVNKCSQTEHWEDLVRYLQMARKKSRESY 1170
Query: 185 IETELAYACAKTNRLADLEEFISGPNHANVTQVADRCFDEKLYDAAKLLYNNVSNYARLA 364
IETEL +A AKT RL +LEEFI+GPNHA + Q+ DRCFD ++D+AK+L+NNVSN+A+L+
Sbjct: 1171 IETELVFALAKTGRLTELEEFIAGPNHAQIGQIGDRCFDNGMFDSAKILFNNVSNFAKLS 1230
Query: 365 ITLVHLGEYHAAVDSARKANSTRTWKEVCFACVDNEEFRLAQMSGMHIVVHADELE 532
+TLV LGEY AVD+ARKANST+TWK+VCF+CV+N EFRLAQM G+HIVVHADELE
Sbjct: 1231 VTLVRLGEYQGAVDAARKANSTKTWKQVCFSCVENGEFRLAQMCGLHIVVHADELE 1286
>sp|P25870|CLH_DICDI Clathrin heavy chain
Length = 1694
Score = 212 bits (539), Expect = 5e-55
Identities = 99/176 (56%), Positives = 137/176 (77%)
Frame = +2
Query: 5 SQLALAQLSEGFIKEAVDSYLKAGDPSQYMKVVEAGKRENNYEDLVRYLQMARKKARETF 184
S+L +AQL +KE ++S++KA D Y +VV A +R++ YEDLV++LQM RKK +E
Sbjct: 1110 SKLGVAQLKAEMVKECIESFIKANDTEHYQEVVAAAERKDEYEDLVKFLQMCRKKIKEPA 1169
Query: 185 IETELAYACAKTNRLADLEEFISGPNHANVTQVADRCFDEKLYDAAKLLYNNVSNYARLA 364
IE+EL +A AK N+LA++E+FI+ PN A++ V DRCF+ LY+AAK+LY N+SN++RL
Sbjct: 1170 IESELIFAYAKVNKLAEMEDFINSPNSAHIQVVGDRCFENGLYEAAKVLYTNISNFSRLT 1229
Query: 365 ITLVHLGEYHAAVDSARKANSTRTWKEVCFACVDNEEFRLAQMSGMHIVVHADELE 532
LV LG+Y AAVD+ARKANST+TWKEV AC+D +EFRLAQ+ G++I+VH DELE
Sbjct: 1230 SCLVKLGQYQAAVDAARKANSTKTWKEVSAACIDAKEFRLAQVCGINIIVHGDELE 1285
>sp|Q10161|CLH_SCHPO Probable clathrin heavy chain
Length = 1666
Score = 189 bits (481), Expect = 3e-48
Identities = 92/175 (52%), Positives = 127/175 (72%)
Frame = +2
Query: 5 SQLALAQLSEGFIKEAVDSYLKAGDPSQYMKVVEAGKRENNYEDLVRYLQMARKKARETF 184
S+LA AQL I +A++SYLKA DPS Y +V+E R YE+L++YL MAR K E
Sbjct: 1105 SRLAKAQLDGIRIPDAIESYLKADDPSNYSEVIELASRAGKYEELIKYLLMARSKMHEPD 1164
Query: 185 IETELAYACAKTNRLADLEEFISGPNHANVTQVADRCFDEKLYDAAKLLYNNVSNYARLA 364
+++ L A AKTN+L ++E F+ G N A+V V D CF+ K Y+AAKL+Y+++SN++ LA
Sbjct: 1165 VDSALLIAYAKTNQLTEMETFLIGSNVADVKAVGDECFESKNYEAAKLMYSSISNWSMLA 1224
Query: 365 ITLVHLGEYHAAVDSARKANSTRTWKEVCFACVDNEEFRLAQMSGMHIVVHADEL 529
TLV+LGEY AVD ARKANS + WK+V AC+D EFRLAQ+ G++++VHA+EL
Sbjct: 1225 TTLVYLGEYQGAVDCARKANSIKVWKQVGTACIDKREFRLAQICGLNLIVHAEEL 1279
>sp|P22137|CLH_YEAST Clathrin heavy chain
Length = 1653
Score = 166 bits (421), Expect = 3e-41
Identities = 80/176 (45%), Positives = 125/176 (71%)
Frame = +2
Query: 5 SQLALAQLSEGFIKEAVDSYLKAGDPSQYMKVVEAGKRENNYEDLVRYLQMARKKARETF 184
SQ+ AQL I +A++SY+KA DPS Y V++ ++ YE+L+ +L MARK +E
Sbjct: 1115 SQIGTAQLDGLRIPDAIESYIKAEDPSNYENVIDIAEQAGKYEELIPFLLMARKTLKEPK 1174
Query: 185 IETELAYACAKTNRLADLEEFISGPNHANVTQVADRCFDEKLYDAAKLLYNNVSNYARLA 364
I+ L A A+ N++ ++E ++G N AN+ V D+ F+ K Y AA+L Y+ VSNY++LA
Sbjct: 1175 IDGALILAYAELNKIHEIENLLAGSNVANLDHVGDKLFENKEYKAARLCYSAVSNYSKLA 1234
Query: 365 ITLVHLGEYHAAVDSARKANSTRTWKEVCFACVDNEEFRLAQMSGMHIVVHADELE 532
TLV+LG+Y AAVD+ARKA++ + WK V AC++ +EF+LAQ+ G++++VHA+EL+
Sbjct: 1235 STLVYLGDYQAAVDTARKASNIKVWKLVNDACIEKKEFKLAQICGLNLIVHAEELD 1290
Database: Non-redundant SwissProt sequences
Posted date: Dec 6, 2005 7:40 AM
Number of letters in database: 68,354,980
Number of sequences in database: 184,735
Database: swissprot.01
Posted date: Dec 6, 2005 8:18 AM
Number of letters in database: 66,202,850
Number of sequences in database: 184,431
Lambda K H
0.318 0.134 0.401
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 54,717,421
Number of Sequences: 369166
Number of extensions: 947441
Number of successful extensions: 2362
Number of sequences better than 10.0: 10
Number of HSP's better than 10.0 without gapping: 2313
Number of HSP's successfully gapped in prelim test: 0
Number of HSP's that attempted gapping in prelim test: 0
Number of HSP's gapped (non-prelim): 2362
length of database: 68,354,980
effective HSP length: 103
effective length of database: 49,327,275
effective search space used: 3650218350
frameshift window, decay const: 40, 0.1
T: 12
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)