Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= Dr_sW_006_F01
(776 letters)
Database: Non-redundant SwissProt sequences
184,735 sequences; 68,354,980 total letters
Score E
Sequences producing significant alignments: (bits) Value
sp|Q9Y4K3|TRAF6_HUMAN TNF receptor-associated factor 6 (Int... 64 4e-10
sp|P70196|TRAF6_MOUSE TNF receptor-associated factor 6 61 4e-09
sp|P70191|TRAF5_MOUSE TNF receptor-associated factor 5 57 7e-08
sp|O00463|TRAF5_HUMAN TNF receptor-associated factor 5 (RIN... 52 2e-06
sp|P39429|TRAF2_MOUSE TNF receptor-associated factor 2 51 3e-06
sp|Q12933|TRAF2_HUMAN TNF receptor-associated factor 2 (Tum... 49 2e-05
sp|Q9BUZ4|TRAF4_HUMAN TNF receptor-associated factor 4 (Cys... 46 1e-04
sp|Q91187|RAG1_ONCMY V(D)J recombination-activating protein... 45 2e-04
sp|Q61382|TRAF4_MOUSE TNF receptor-associated factor 4 (Cys... 45 3e-04
sp|O13033|RAG1_BRARE V(D)J recombination-activating protein... 44 6e-04
>sp|Q9Y4K3|TRAF6_HUMAN TNF receptor-associated factor 6 (Interleukin 1 signal transducer)
(RING finger protein 85)
Length = 522
Score = 64.3 bits (155), Expect = 4e-10
Identities = 40/117 (34%), Positives = 61/117 (52%), Gaps = 1/117 (0%)
Frame = +1
Query: 133 KCVIWKEILVNAQQSLCGCHFCQICI-KNYQNSGSKNCPGNTDECKSENLTNIFPDRGTN 309
+C I L A Q+ CG FC+ CI K+ +++G K CP + +E EN +FPD
Sbjct: 69 ECPICLMALREAVQTPCGHRFCKACIIKSIRDAGHK-CPVD-NEILLEN--QLFPDNFAK 124
Query: 310 KRISNLIARCPHESCSHECRLIEMEDHMRFCSTRNVNCPFNNVGCEHEEMNIDKLDD 480
+ I +L+ +CP+E C H+ L +EDH C ++CP + +NI L D
Sbjct: 125 REILSLMVKCPNEGCLHKMELRHLEDHQAHCEFALMDCPQCQRPFQKFHINIHILKD 181
Score = 34.3 bits (77), Expect = 0.39
Identities = 31/123 (25%), Positives = 53/123 (43%), Gaps = 12/123 (9%)
Frame = +1
Query: 235 KNCPGNTDECKSENLTNIFPDR---GTNKRISNLIARCPHESCSHECRLIEMEDHMRF-C 402
K+CP C + + F D+ N ++N+I E C+ +M +H C
Sbjct: 180 KDCPRRQVSCDNCAASMAFEDKEIHDQNCPLANVIC----EYCNTILIREQMPNHYDLDC 235
Query: 403 STRNVNCPFNNVGCEHEEMNIDKLDDHMLLEIVNHNKILIDIIGNLR--------SDVRE 558
T + C F+ GC HE+M + L H+ +H ++L + +L S+VR
Sbjct: 236 PTAPIPCTFSTFGC-HEKMQRNHLARHLQENTQSHMRMLAQAVHSLSVIPDSGYISEVRN 294
Query: 559 LKE 567
+E
Sbjct: 295 FQE 297
>sp|P70196|TRAF6_MOUSE TNF receptor-associated factor 6
Length = 530
Score = 60.8 bits (146), Expect = 4e-09
Identities = 36/99 (36%), Positives = 53/99 (53%), Gaps = 1/99 (1%)
Frame = +1
Query: 133 KCVIWKEILVNAQQSLCGCHFCQICI-KNYQNSGSKNCPGNTDECKSENLTNIFPDRGTN 309
+C I L A Q+ CG FC+ CI K+ +++G K CP + +E EN +FPD
Sbjct: 69 ECPICLMALREAVQTPCGHRFCKACIIKSIRDAGHK-CPVD-NEILLEN--QLFPDNFAK 124
Query: 310 KRISNLIARCPHESCSHECRLIEMEDHMRFCSTRNVNCP 426
+ I +L +CP++ C + L +EDH C VNCP
Sbjct: 125 REILSLTVKCPNKGCLQKMELRHLEDHQVHCEFALVNCP 163
>sp|P70191|TRAF5_MOUSE TNF receptor-associated factor 5
Length = 558
Score = 56.6 bits (135), Expect = 7e-08
Identities = 34/126 (26%), Positives = 57/126 (45%), Gaps = 2/126 (1%)
Frame = +1
Query: 97 KFTIINEINEDLKCVIWKEILVNAQQSLCGCHFCQICIKNYQNSGS-KNCPGNTDECKSE 273
++ + ++ E KC +L N Q+ CG FCQ CI++ + S CP + + K +
Sbjct: 32 EYQFVEQLEERYKCAFCHSVLHNPHQTGCGHRFCQQCIRSLRELNSVPICPVDKEVIKPQ 91
Query: 274 NLTNIFPDRGTNKRISNLIARCPH-ESCSHECRLIEMEDHMRFCSTRNVNCPFNNVGCEH 450
+F D + + NL C + C+ L +DH++ CS + V CP N C
Sbjct: 92 ---EVFKDNCCKREVLNLHVYCKNAPGCNARIILGRFQDHLQHCSFQAVPCP--NESCRE 146
Query: 451 EEMNID 468
+ D
Sbjct: 147 AMLRKD 152
Score = 33.1 bits (74), Expect = 0.87
Identities = 24/88 (27%), Positives = 36/88 (40%), Gaps = 10/88 (11%)
Frame = +1
Query: 337 CPHESCSHECRLIEMEDHMRFCSTRNVNCPFNNVGC----------EHEEMNIDKLDDHM 486
CP+ C + +H+ C +CPF + GC EHE L DHM
Sbjct: 195 CPNR-CVQTIPRARVNEHLTVCPEAEQDCPFKHYGCTVKGKRGNLLEHERA---ALQDHM 250
Query: 487 LLEIVNHNKILIDIIGNLRSDVRELKEK 570
LL ++ N L I +L + + + K
Sbjct: 251 LL-VLEKNYQLEQRISDLYQSLEQKESK 277
>sp|O00463|TRAF5_HUMAN TNF receptor-associated factor 5 (RING finger protein 84)
Length = 557
Score = 51.6 bits (122), Expect = 2e-06
Identities = 34/132 (25%), Positives = 60/132 (45%), Gaps = 2/132 (1%)
Frame = +1
Query: 97 KFTIINEINEDLKCVIWKEILVNAQQSLCGCHFCQICIKNYQNSGS-KNCPGNTDECKSE 273
++ + + E KC +L N Q+ CG FCQ CI + + + CP + + KS+
Sbjct: 32 EYQFVERLEERYKCAFCHSVLHNPHQTGCGHRFCQHCILSLRELNTVPICPVDKEVIKSQ 91
Query: 274 NLTNIFPDRGTNKRISNLIARCPH-ESCSHECRLIEMEDHMRFCSTRNVNCPFNNVGCEH 450
+F D + + NL C + C+ + L +DH++ C + V C +N C
Sbjct: 92 ---EVFKDNCCKREVLNLYVYCSNAPGCNAKVILGRYQDHLQQCLFQPVQC--SNEKCRE 146
Query: 451 EEMNIDKLDDHM 486
+ D L +H+
Sbjct: 147 PVLRKD-LKEHL 157
Score = 32.3 bits (72), Expect = 1.5
Identities = 22/88 (25%), Positives = 40/88 (45%), Gaps = 10/88 (11%)
Frame = +1
Query: 337 CPHESCSHECRLIEMEDHMRFCSTRNVNCPFNNVGC----------EHEEMNIDKLDDHM 486
CP+ +C+ E+++H+ C +CPF + GC +HE L +HM
Sbjct: 195 CPN-NCAKIILKTEVDEHLAVCPEAEQDCPFKHYGCAVTDKRRNLQQHEH---SALREHM 250
Query: 487 LLEIVNHNKILIDIIGNLRSDVRELKEK 570
L ++ N L + I +L + + + K
Sbjct: 251 RL-VLEKNVQLEEQISDLHKSLEQKESK 277
>sp|P39429|TRAF2_MOUSE TNF receptor-associated factor 2
Length = 501
Score = 51.2 bits (121), Expect = 3e-06
Identities = 31/104 (29%), Positives = 45/104 (43%), Gaps = 7/104 (6%)
Frame = +1
Query: 136 CVIWKEILVNAQQSLCGCHFCQICIKNYQNSGSKNCPGNTDECKSENLTNI------FPD 297
C K IL Q+ CG +C C+ + +SG +NC E E +I FPD
Sbjct: 34 CSACKNILRRPFQAQCGHRYCSFCLTSILSSGPQNCAACVYEGLYEEGISILESSSAFPD 93
Query: 298 RGTNKRISNLIARCPHESCSHECRLIEMED-HMRFCSTRNVNCP 426
+ + +L A CP++ C+ + L E E H C CP
Sbjct: 94 NAARREVESLPAVCPNDGCTWKGTLKEYESCHEGLCPFLLTECP 137
>sp|Q12933|TRAF2_HUMAN TNF receptor-associated factor 2 (Tumor necrosis factor type 2
receptor-associated protein 3)
Length = 501
Score = 48.9 bits (115), Expect = 2e-05
Identities = 29/104 (27%), Positives = 44/104 (42%), Gaps = 7/104 (6%)
Frame = +1
Query: 136 CVIWKEILVNAQQSLCGCHFCQICIKNYQNSGSKNCPGNTDECKSENLTNI------FPD 297
C + +L Q+ CG +C C+ + +SG +NC E E +I FPD
Sbjct: 34 CSACRNVLRRPFQAQCGHRYCSFCLASILSSGPQNCAACVHEGIYEEGISILESSSAFPD 93
Query: 298 RGTNKRISNLIARCPHESCSHECRLIEMED-HMRFCSTRNVNCP 426
+ + +L A CP + C+ + L E E H C CP
Sbjct: 94 NAARREVESLPAVCPSDGCTWKGTLKEYESCHEGRCPLMLTECP 137
>sp|Q9BUZ4|TRAF4_HUMAN TNF receptor-associated factor 4 (Cysteine-rich domain associated
with RING and Traf domains protein 1) (Malignant 62)
(RING finger protein 83)
Length = 470
Score = 46.2 bits (108), Expect = 1e-04
Identities = 25/88 (28%), Positives = 39/88 (44%), Gaps = 2/88 (2%)
Frame = +1
Query: 169 QQSLCGCHFCQICIKNYQNSGSKNCPGNTDECKSENLTNIFPDRGTNKRISNLIARCPH- 345
Q S CG FC C++ + + G CP ++ + I+PD ++ L RC H
Sbjct: 30 QVSTCGHRFCDTCLQEFLSEGVFKCP---EDQLPLDYAKIYPDPELEVQVLGLPIRCIHS 86
Query: 346 -ESCSHECRLIEMEDHMRFCSTRNVNCP 426
E C L ++ H+ CS + CP
Sbjct: 87 EEGCRWSGPLRHLQGHLNTCSFNVIPCP 114
Score = 36.6 bits (83), Expect = 0.079
Identities = 27/137 (19%), Positives = 59/137 (43%), Gaps = 2/137 (1%)
Frame = +1
Query: 172 QSLCGCHFCQICIKNYQNSGSKNCPGNTDECKSENLTNIFPDRGTNK-RISNLIARCPHE 348
++ CG + + + S CP T C +F +++ + L CP++
Sbjct: 168 ENKCGARMMRRLLAQHATS---ECPKRTQPCTYCTKEFVFDTIQSHQYQCPRLPVACPNQ 224
Query: 349 SCSHECRLIEMEDHMR-FCSTRNVNCPFNNVGCEHEEMNIDKLDDHMLLEIVNHNKILID 525
++ H++ C+T V CPF + GC+H + + H+ + H ++
Sbjct: 225 CGVGTVAREDLPGHLKDSCNTALVLCPFKDSGCKHRCPKL-AMARHVEESVKPHLAMMCA 283
Query: 526 IIGNLRSDVRELKEKEE 576
++ R +++EL+ + E
Sbjct: 284 LVSRQRQELQELRRELE 300
>sp|Q91187|RAG1_ONCMY V(D)J recombination-activating protein 1 (RAG-1)
Length = 1073
Score = 45.4 bits (106), Expect = 2e-04
Identities = 28/85 (32%), Positives = 37/85 (43%)
Frame = +1
Query: 136 CVIWKEILVNAQQSLCGCHFCQICIKNYQNSGSKNCPGNTDECKSENLTNIFPDRGTNKR 315
C + +L QS C FC+ CI Y S +CP T C +LT P +G
Sbjct: 310 CQVCDHLLSEPVQSPCRHLFCRSCIAKYIYSLGPHCPACTLPCGPADLT--APAKGFLGV 367
Query: 316 ISNLIARCPHESCSHECRLIEMEDH 390
+ +L CP ESC + RL H
Sbjct: 368 LHSLPLLCpreSCGEQVRLDSFRAH 392
>sp|Q61382|TRAF4_MOUSE TNF receptor-associated factor 4 (Cysteine-rich motif associated to
RING and Traf domains protein 1)
Length = 470
Score = 44.7 bits (104), Expect = 3e-04
Identities = 24/90 (26%), Positives = 40/90 (44%), Gaps = 2/90 (2%)
Frame = +1
Query: 163 NAQQSLCGCHFCQICIKNYQNSGSKNCPGNTDECKSENLTNIFPDRGTNKRISNLIARCP 342
+ + S CG +C C++ + + G CP ++ + I+PD ++ L RC
Sbjct: 28 SVEVSTCGHRYCDNCLQEFLSEGVFKCP---EDQLPLDYAKIYPDPELEVQVLGLAIRCI 84
Query: 343 H--ESCSHECRLIEMEDHMRFCSTRNVNCP 426
H E C L ++ H+ CS V CP
Sbjct: 85 HSEEGCRWSGPLRHLQGHLNTCSFNVVPCP 114
Score = 34.3 bits (77), Expect = 0.39
Identities = 26/137 (18%), Positives = 57/137 (41%), Gaps = 2/137 (1%)
Frame = +1
Query: 172 QSLCGCHFCQICIKNYQNSGSKNCPGNTDECKSENLTNIFPDRGTNK-RISNLIARCPHE 348
++ CG + + + S CP T C ++ +++ + L CP++
Sbjct: 168 ENKCGARMMRRLLAQHATS---ECPKRTQPCAYCTKEFVYDTIQSHQYQCPRLPVPCPNQ 224
Query: 349 SCSHECRLIEMEDHMR-FCSTRNVNCPFNNVGCEHEEMNIDKLDDHMLLEIVNHNKILID 525
++ H++ C T V CPF GC+H + + H+ + H ++
Sbjct: 225 CGVGTVAREDLPTHLKDSCRTAFVLCPFKESGCKHRCPKL-AMGRHVEESVKPHLAMMCA 283
Query: 526 IIGNLRSDVRELKEKEE 576
++ R +++EL+ + E
Sbjct: 284 LVSRQRQELQELRRELE 300
>sp|O13033|RAG1_BRARE V(D)J recombination-activating protein 1 (RAG-1)
Length = 1057
Score = 43.5 bits (101), Expect = 6e-04
Identities = 26/85 (30%), Positives = 38/85 (44%)
Frame = +1
Query: 136 CVIWKEILVNAQQSLCGCHFCQICIKNYQNSGSKNCPGNTDECKSENLTNIFPDRGTNKR 315
C + +L + QS C FC++CI Y ++ NCP +L I P +
Sbjct: 296 CQVCDHLLSDPVQSPCRHLFCRLCIIRYTHALGPNCPTCNQHLNPSHL--IKPAKFFLAT 353
Query: 316 ISNLIARCPHESCSHECRLIEMEDH 390
+S+L CP E CS RL +H
Sbjct: 354 LSSLPLLCPSEECSDWVRLDSFREH 378
Database: Non-redundant SwissProt sequences
Posted date: Dec 6, 2005 7:40 AM
Number of letters in database: 68,354,980
Number of sequences in database: 184,735
Database: swissprot.01
Posted date: Dec 6, 2005 8:18 AM
Number of letters in database: 66,202,850
Number of sequences in database: 184,431
Lambda K H
0.318 0.134 0.401
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 71,321,126
Number of Sequences: 369166
Number of extensions: 1350339
Number of successful extensions: 3974
Number of sequences better than 10.0: 10
Number of HSP's better than 10.0 without gapping: 3805
Number of HSP's successfully gapped in prelim test: 0
Number of HSP's that attempted gapping in prelim test: 0
Number of HSP's gapped (non-prelim): 3961
length of database: 68,354,980
effective HSP length: 108
effective length of database: 48,403,600
effective search space used: 7260540000
frameshift window, decay const: 40, 0.1
T: 12
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)