Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= Dr_sW_006_C18
(736 letters)
Database: Non-redundant SwissProt sequences
184,735 sequences; 68,354,980 total letters
Score E
Sequences producing significant alignments: (bits) Value
sp|Q5G268|NETR_HYLLE Neurotrypsin precursor 190 3e-48
sp|Q5G265|NETR_SAGLB Neurotrypsin precursor 190 4e-48
sp|Q5G266|NETR_TRAPH Neurotrypsin precursor 189 5e-48
sp|Q5G267|NETR_MACMU Neurotrypsin precursor 189 5e-48
sp|P56730|NETR_HUMAN Neurotrypsin precursor (Motopsin) (Ley... 189 9e-48
sp|Q9JIQ8|TMPS2_MOUSE Transmembrane protease, serine 2 (Epi... 187 2e-47
sp|Q5G270|NETR_GORGO Neurotrypsin precursor 187 2e-47
sp|Q5G269|NETR_PONPY Neurotrypsin precursor 187 3e-47
sp|Q5G271|NETR_PANTR Neurotrypsin precursor 186 7e-47
sp|O15393|TMPS2_HUMAN Transmembrane protease, serine 2 prec... 185 9e-47
>sp|Q5G268|NETR_HYLLE Neurotrypsin precursor
Length = 875
Score = 190 bits (483), Expect = 3e-48
Identities = 97/251 (38%), Positives = 152/251 (60%), Gaps = 8/251 (3%)
Frame = +2
Query: 8 CGKKPITQRRGRVVGGFETIYGAFPWQVGVRHRMSDYDVHW-CGGSILSEDWILSAAHCY 184
CG + + +R+ R++GG ++ G +PWQV +R + S D CG ++LS W+L+AAHC+
Sbjct: 619 CGLRLLHRRQKRIIGGKNSLRGGWPWQVSLRLKSSHGDGRLLCGATLLSSCWVLTAAHCF 678
Query: 185 ERPKNQ---YFVRTGDWNNNELDIYEQTFEVEELFINPKYQGPPTYDYDMAIIKIKRING 355
+R N Y VR GD++ + +E+ V+++ I+ +Y+ P + DYD+A+++++
Sbjct: 679 KRYGNSTRNYAVRVGDYHTLVPEEFEEEIGVQQIVIHREYR-PDSSDYDIALVRLQGPEE 737
Query: 356 VGIMFNDHVQPVCLPNPEMVPD-LKTKCLVSGWGDTLSERTEKLLAAEVPLIKSERCNEF 532
F+ HV P CLP P + C ++GWGDT + L A +PL+ C E
Sbjct: 738 QCARFSSHVLPACLPLWRERPQKTASNCYITGWGDTGRAYSRTLQQAAIPLLPKRFCEER 797
Query: 533 YKGRITDRMQCAG--YEHGGIDTCQGDSGGPLVCQVNG-IYTIFGATSWGDGCAVPRSPG 703
YKGR T RM CAG +EH +D+CQGDSGGPL+C+ G + ++G TSWG GC V SPG
Sbjct: 798 YKGRFTGRMLCAGNLHEHKRVDSCQGDSGGPLMCERPGESWVVYGVTSWGHGCGVKDSPG 857
Query: 704 VYARTASMLDY 736
VY + ++ + +
Sbjct: 858 VYTKVSAFVPW 868
>sp|Q5G265|NETR_SAGLB Neurotrypsin precursor
Length = 875
Score = 190 bits (482), Expect = 4e-48
Identities = 98/251 (39%), Positives = 151/251 (60%), Gaps = 8/251 (3%)
Frame = +2
Query: 8 CGKKPITQRRGRVVGGFETIYGAFPWQVGVRHRMSDYDVHW-CGGSILSEDWILSAAHCY 184
CG + + +R+ R++GG ++ G +PWQV +R + S D CG ++LS W+L+AAHC+
Sbjct: 619 CGLRLLHRRQKRIIGGKNSLRGGWPWQVSLRLKSSHRDGRLLCGATLLSSCWVLTAAHCF 678
Query: 185 ERPKNQ---YFVRTGDWNNNELDIYEQTFEVEELFINPKYQGPPTYDYDMAIIKIKRING 355
+R N Y VR GD++ + +E+ V+E+ I+ +Y+ P + DYD+A+++++
Sbjct: 679 KRYGNSTRNYAVRVGDYHTLVPEEFEEEIGVQEIVIHREYR-PDSSDYDIALVRLQGPEE 737
Query: 356 VGIMFNDHVQPVCLPNPEMVPD-LKTKCLVSGWGDTLSERTEKLLAAEVPLIKSERCNEF 532
FN HV P CLP P + C ++GWGDT + L A + L+ C E
Sbjct: 738 QCARFNSHVLPACLPLWRERPQKTASNCYITGWGDTGQAYSRTLQQAAIHLLPKRFCEER 797
Query: 533 YKGRITDRMQCAG--YEHGGIDTCQGDSGGPLVCQVNG-IYTIFGATSWGDGCAVPRSPG 703
YKGR T RM CAG +EH +D+CQGDSGGPL+C+ G + ++G TSWG GC V SPG
Sbjct: 798 YKGRFTGRMLCAGNLHEHKHVDSCQGDSGGPLMCERPGESWVVYGVTSWGYGCGVKDSPG 857
Query: 704 VYARTASMLDY 736
VY + ++ + +
Sbjct: 858 VYTKVSAFVPW 868
>sp|Q5G266|NETR_TRAPH Neurotrypsin precursor
Length = 875
Score = 189 bits (481), Expect = 5e-48
Identities = 97/251 (38%), Positives = 152/251 (60%), Gaps = 8/251 (3%)
Frame = +2
Query: 8 CGKKPITQRRGRVVGGFETIYGAFPWQVGVRHRMSDYDVHW-CGGSILSEDWILSAAHCY 184
CG + + +R+ R++GG ++ G +PWQV +R + S D CG ++LS W+L+AAHC+
Sbjct: 619 CGLRLLHRRQKRIIGGKNSLRGGWPWQVSLRLKSSHGDGRLLCGATLLSSCWVLTAAHCF 678
Query: 185 ERPKNQ---YFVRTGDWNNNELDIYEQTFEVEELFINPKYQGPPTYDYDMAIIKIKRING 355
+R N Y VR GD++ + +E+ V+++ I+ +Y+ P + DYD+A+++++
Sbjct: 679 KRYGNSTRNYAVRVGDYHTLVPEEFEEEIGVQQIVIHREYR-PDSSDYDIALVRLQGPEE 737
Query: 356 VGIMFNDHVQPVCLPNPEMVPD-LKTKCLVSGWGDTLSERTEKLLAAEVPLIKSERCNEF 532
F+ HV P CLP P + C ++GWGDT + L A +PL+ C E
Sbjct: 738 QCARFSSHVLPACLPFWRERPQKTASNCYITGWGDTGRAYSRTLQQAAIPLLPKRFCEER 797
Query: 533 YKGRITDRMQCAG--YEHGGIDTCQGDSGGPLVCQVNG-IYTIFGATSWGDGCAVPRSPG 703
YKGR T RM CAG +EH +D+CQGDSGGPL+C+ G + ++G TSWG GC V SPG
Sbjct: 798 YKGRFTGRMLCAGNLHEHKRVDSCQGDSGGPLMCERPGESWAVYGVTSWGYGCGVKDSPG 857
Query: 704 VYARTASMLDY 736
VY + ++ + +
Sbjct: 858 VYTKVSAFVPW 868
>sp|Q5G267|NETR_MACMU Neurotrypsin precursor
Length = 875
Score = 189 bits (481), Expect = 5e-48
Identities = 97/251 (38%), Positives = 152/251 (60%), Gaps = 8/251 (3%)
Frame = +2
Query: 8 CGKKPITQRRGRVVGGFETIYGAFPWQVGVRHRMSDYDVHW-CGGSILSEDWILSAAHCY 184
CG + + +R+ R++GG ++ G +PWQV +R + S D CG ++LS W+L+AAHC+
Sbjct: 619 CGLRLLHRRQKRIIGGKNSLRGGWPWQVSLRLKSSHGDGRLLCGATLLSSCWVLTAAHCF 678
Query: 185 ERPKNQ---YFVRTGDWNNNELDIYEQTFEVEELFINPKYQGPPTYDYDMAIIKIKRING 355
+R N Y VR GD++ + +E+ V+++ I+ +Y+ P + DYD+A+++++
Sbjct: 679 KRYGNSTRNYAVRVGDYHTLVPEEFEEEIGVQQIVIHREYR-PDSSDYDIALVRLQGPEE 737
Query: 356 VGIMFNDHVQPVCLPNPEMVPD-LKTKCLVSGWGDTLSERTEKLLAAEVPLIKSERCNEF 532
F+ HV P CLP P + C ++GWGDT + L A +PL+ C E
Sbjct: 738 QCARFSSHVLPACLPFWRERPQKTASNCYITGWGDTGRAYSRTLQQAAIPLLPKRFCEER 797
Query: 533 YKGRITDRMQCAG--YEHGGIDTCQGDSGGPLVCQVNG-IYTIFGATSWGDGCAVPRSPG 703
YKGR T RM CAG +EH +D+CQGDSGGPL+C+ G + ++G TSWG GC V SPG
Sbjct: 798 YKGRFTGRMLCAGNLHEHKRVDSCQGDSGGPLMCERPGESWAVYGVTSWGYGCGVKDSPG 857
Query: 704 VYARTASMLDY 736
VY + ++ + +
Sbjct: 858 VYTKVSAFVPW 868
>sp|P56730|NETR_HUMAN Neurotrypsin precursor (Motopsin) (Leydin)
Length = 875
Score = 189 bits (479), Expect = 9e-48
Identities = 97/251 (38%), Positives = 151/251 (60%), Gaps = 8/251 (3%)
Frame = +2
Query: 8 CGKKPITQRRGRVVGGFETIYGAFPWQVGVRHRMSDYDVHW-CGGSILSEDWILSAAHCY 184
CG + + +R+ R++GG ++ G +PWQV +R + S D CG ++LS W+L+AAHC+
Sbjct: 619 CGLRLLHRRQKRIIGGKNSLRGGWPWQVSLRLKSSHGDGRLLCGATLLSSCWVLTAAHCF 678
Query: 185 ERPKNQ---YFVRTGDWNNNELDIYEQTFEVEELFINPKYQGPPTYDYDMAIIKIKRING 355
+R N Y VR GD++ + +E+ V+++ I+ +Y+ P DYD+A+++++
Sbjct: 679 KRYGNSTRSYAVRVGDYHTLVPEEFEEEIGVQQIVIHREYR-PDRSDYDIALVRLQGPEE 737
Query: 356 VGIMFNDHVQPVCLPNPEMVPD-LKTKCLVSGWGDTLSERTEKLLAAEVPLIKSERCNEF 532
F+ HV P CLP P + C ++GWGDT + L A +PL+ C E
Sbjct: 738 QCARFSSHVLPACLPLWRERPQKTASNCYITGWGDTGRAYSRTLQQAAIPLLPKRFCEER 797
Query: 533 YKGRITDRMQCAG--YEHGGIDTCQGDSGGPLVCQVNG-IYTIFGATSWGDGCAVPRSPG 703
YKGR T RM CAG +EH +D+CQGDSGGPL+C+ G + ++G TSWG GC V SPG
Sbjct: 798 YKGRFTGRMLCAGNLHEHKRVDSCQGDSGGPLMCERPGESWVVYGVTSWGYGCGVKDSPG 857
Query: 704 VYARTASMLDY 736
VY + ++ + +
Sbjct: 858 VYTKVSAFVPW 868
>sp|Q9JIQ8|TMPS2_MOUSE Transmembrane protease, serine 2 (Epitheliasin) (Plasmic
transmembrane protein X) [Contains: Transmembrane
protease, serine 2 non-catalytic chain; Transmembrane
protease, serine 2 catalytic chain]
Length = 490
Score = 187 bits (476), Expect = 2e-47
Identities = 102/251 (40%), Positives = 145/251 (57%), Gaps = 6/251 (2%)
Frame = +2
Query: 2 VSCGKKPITQRRGRVVGGFETIYGAFPWQVGVRHRMSDYDVHWCGGSILSEDWILSAAHC 181
+ CG + + +R+ R+VGG G +PWQV + + VH CGGSI++ +WI++AAHC
Sbjct: 241 IECGVRSV-KRQSRIVGGLNASPGDWPWQVSLHVQ----GVHVCGGSIITPEWIVTAAHC 295
Query: 182 YERPKN--QYFVRTGDWNNNELDIYEQTFEVEELFINPKYQGPPTYDYDMAIIKIKRING 355
E P + +Y+ L Y +VE++ +P Y T + D+A++K++
Sbjct: 296 VEEPLSGPRYWTAFAGILRQSLMFYGSRHQVEKVISHPNYDSK-TKNNDIALMKLQ---- 350
Query: 356 VGIMFNDHVQPVCLPNPEMVPDLKTKCLVSGWGDTLSE--RTEKLLAAEVPLIKSERCNE 529
+ FND V+PVCLPNP M+ DL +C +SGWG T + ++ L AA VPLI+ +CN
Sbjct: 351 TPLAFNDLVKPVCLPNPGMMLDLDQECWISGWGATYEKGKTSDVLNAAMVPLIEPSKCNS 410
Query: 530 --FYKGRITDRMQCAGYEHGGIDTCQGDSGGPLVCQVNGIYTIFGATSWGDGCAVPRSPG 703
Y IT M CAG+ G +D+CQGDSGGPLV NGI+ + G TSWG GCA PG
Sbjct: 411 KYIYNNLITPAMICAGFLQGSVDSCQGDSGGPLVTLKNGIWWLIGDTSWGSGCAKALRPG 470
Query: 704 VYARTASMLDY 736
VY D+
Sbjct: 471 VYGNVTVFTDW 481
>sp|Q5G270|NETR_GORGO Neurotrypsin precursor
Length = 876
Score = 187 bits (475), Expect = 2e-47
Identities = 96/251 (38%), Positives = 151/251 (60%), Gaps = 8/251 (3%)
Frame = +2
Query: 8 CGKKPITQRRGRVVGGFETIYGAFPWQVGVRHRMSDYDVHW-CGGSILSEDWILSAAHCY 184
CG + + +R+ R++GG ++ G +PWQV +R + D CG ++LS W+L+AAHC+
Sbjct: 620 CGLRLLHRRQKRIIGGKNSLRGGWPWQVSLRLKSYHGDGRLLCGATLLSSCWVLTAAHCF 679
Query: 185 ERPKNQ---YFVRTGDWNNNELDIYEQTFEVEELFINPKYQGPPTYDYDMAIIKIKRING 355
+R N Y VR GD++ + +E+ V+++ I+ +Y+ P + DYD+A+++++
Sbjct: 680 KRYGNSTRNYAVRVGDYHTLVPEEFEEEIGVQQIVIHREYR-PDSSDYDIALVRLQGPEE 738
Query: 356 VGIMFNDHVQPVCLPNPEMVPD-LKTKCLVSGWGDTLSERTEKLLAAEVPLIKSERCNEF 532
F+ HV P CLP P + C ++GWGDT + L A +PL+ C E
Sbjct: 739 QCARFSSHVLPACLPLWRERPQKTASNCYITGWGDTGRAYSRTLQQAAIPLLPKRFCEER 798
Query: 533 YKGRITDRMQCAG--YEHGGIDTCQGDSGGPLVCQVNG-IYTIFGATSWGDGCAVPRSPG 703
YKGR T RM CAG +EH +D+CQGDSGGPL+C+ G + ++G TSWG GC V SPG
Sbjct: 799 YKGRFTGRMLCAGNLHEHKRVDSCQGDSGGPLMCERPGESWVVYGVTSWGYGCGVKDSPG 858
Query: 704 VYARTASMLDY 736
VY + ++ + +
Sbjct: 859 VYTKVSAFVPW 869
>sp|Q5G269|NETR_PONPY Neurotrypsin precursor
Length = 877
Score = 187 bits (474), Expect = 3e-47
Identities = 96/251 (38%), Positives = 151/251 (60%), Gaps = 8/251 (3%)
Frame = +2
Query: 8 CGKKPITQRRGRVVGGFETIYGAFPWQVGVRHRMSDYDVHW-CGGSILSEDWILSAAHCY 184
CG + + +R+ R++GG ++ G +PWQV +R + S D CG ++LS W+L+AAHC+
Sbjct: 621 CGLRLLHRRQKRIIGGKNSLRGGWPWQVSLRLKSSHGDGRLLCGATLLSSCWVLTAAHCF 680
Query: 185 ERPKNQ---YFVRTGDWNNNELDIYEQTFEVEELFINPKYQGPPTYDYDMAIIKIKRING 355
+R N Y VR GD++ + +E+ V+++ I+ +Y+ P + DYD+A+++++
Sbjct: 681 KRYGNSTRNYAVRVGDYHTLVPEEFEEEVGVQQIVIHREYR-PDSSDYDIALVRLQGPEE 739
Query: 356 VGIMFNDHVQPVCLPNPEMVPD-LKTKCLVSGWGDTLSERTEKLLAAEVPLIKSERCNEF 532
F+ HV P CLP P + C ++GWGDT + L A +PL+ C E
Sbjct: 740 QCARFSSHVLPACLPLWRERPQKTASNCYITGWGDTGRAYSRTLQQAAIPLLPKRFCEER 799
Query: 533 YKGRITDRMQCAG--YEHGGIDTCQGDSGGPLVCQVNG-IYTIFGATSWGDGCAVPRSPG 703
YKG T RM CAG +EH +D+CQGDSGGPL+C+ G + ++G TSWG GC V SPG
Sbjct: 800 YKGXFTGRMLCAGNLHEHKRVDSCQGDSGGPLMCERPGESWVVYGVTSWGYGCGVKDSPG 859
Query: 704 VYARTASMLDY 736
VY + ++ + +
Sbjct: 860 VYTKVSAFVPW 870
>sp|Q5G271|NETR_PANTR Neurotrypsin precursor
Length = 875
Score = 186 bits (471), Expect = 7e-47
Identities = 96/251 (38%), Positives = 150/251 (59%), Gaps = 8/251 (3%)
Frame = +2
Query: 8 CGKKPITQRRGRVVGGFETIYGAFPWQVGVRHRMSDYDVHW-CGGSILSEDWILSAAHCY 184
CG + + +R+ R++GG ++ G +PWQV +R + S D CG ++LS W+L+AAHC+
Sbjct: 619 CGLRLLHRRQKRIIGGKNSLRGGWPWQVSLRLKSSHGDGRLLCGATLLSSCWVLTAAHCF 678
Query: 185 ERPKNQ---YFVRTGDWNNNELDIYEQTFEVEELFINPKYQGPPTYDYDMAIIKIKRING 355
+R N Y VR GD++ + +E+ V+++ I+ +Y+ P DYD+A+++++
Sbjct: 679 KRYGNSTRSYAVRVGDYHTLVPEEFEEEIGVQQIVIHREYR-PDRSDYDIALVRLQGPEE 737
Query: 356 VGIMFNDHVQPVCLPNPEMVPD-LKTKCLVSGWGDTLSERTEKLLAAEVPLIKSERCNEF 532
F+ HV P CLP P + C ++GWGDT + L A +PL+ C E
Sbjct: 738 QCARFSSHVLPACLPLWRERPQKTASNCYITGWGDTGRAYSRTLQQAAIPLLPKRFCEER 797
Query: 533 YKGRITDRMQCAG--YEHGGIDTCQGDSGGPLVCQVNG-IYTIFGATSWGDGCAVPRSPG 703
YK R T RM CAG +EH +D+CQGDSGGPL+C+ G + ++G TSWG GC V SPG
Sbjct: 798 YKRRFTGRMLCAGNLHEHKRVDSCQGDSGGPLMCERPGESWVVYGVTSWGYGCGVKDSPG 857
Query: 704 VYARTASMLDY 736
VY + ++ + +
Sbjct: 858 VYTKVSAFVPW 868
>sp|O15393|TMPS2_HUMAN Transmembrane protease, serine 2 precursor [Contains: Transmembrane
protease, serine 2 non-catalytic chain; Transmembrane
protease, serine 2 catalytic chain]
Length = 492
Score = 185 bits (470), Expect = 9e-47
Identities = 100/251 (39%), Positives = 147/251 (58%), Gaps = 6/251 (2%)
Frame = +2
Query: 2 VSCGKKPITQRRGRVVGGFETIYGAFPWQVGVRHRMSDYDVHWCGGSILSEDWILSAAHC 181
++CG + R+ R+VGG + GA+PWQV + + +VH CGGSI++ +WI++AAHC
Sbjct: 242 IACGVNLNSSRQSRIVGGESALPGAWPWQVSLHVQ----NVHVCGGSIITPEWIVTAAHC 297
Query: 182 YERPKNQ--YFVRTGDWNNNELDIYEQTFEVEELFINPKYQGPPTYDYDMAIIKIKRING 355
E+P N ++ Y ++VE++ +P Y T + D+A++K+++
Sbjct: 298 VEKPLNNPWHWTAFAGILRQSFMFYGAGYQVEKVISHPNYDSK-TKNNDIALMKLQK--- 353
Query: 356 VGIMFNDHVQPVCLPNPEMVPDLKTKCLVSGWGDT--LSERTEKLLAAEVPLIKSERCNE 529
+ FND V+PVCLPNP M+ + C +SGWG T + +E L AA+V LI+++RCN
Sbjct: 354 -PLTFNDLVKPVCLPNPGMMLQPEQLCWISGWGATEEKGKTSEVLNAAKVLLIETQRCNS 412
Query: 530 --FYKGRITDRMQCAGYEHGGIDTCQGDSGGPLVCQVNGIYTIFGATSWGDGCAVPRSPG 703
Y IT M CAG+ G +D+CQGDSGGPLV N I+ + G TSWG GCA PG
Sbjct: 413 RYVYDNLITPAMICAGFLQGNVDSCQGDSGGPLVTSKNNIWWLIGDTSWGSGCAKAYRPG 472
Query: 704 VYARTASMLDY 736
VY D+
Sbjct: 473 VYGNVMVFTDW 483
Database: Non-redundant SwissProt sequences
Posted date: Dec 6, 2005 7:40 AM
Number of letters in database: 68,354,980
Number of sequences in database: 184,735
Database: swissprot.01
Posted date: Dec 6, 2005 8:18 AM
Number of letters in database: 66,202,850
Number of sequences in database: 184,431
Lambda K H
0.318 0.134 0.401
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 98,015,731
Number of Sequences: 369166
Number of extensions: 2264584
Number of successful extensions: 8424
Number of sequences better than 10.0: 10
Number of HSP's better than 10.0 without gapping: 6763
Number of HSP's successfully gapped in prelim test: 0
Number of HSP's that attempted gapping in prelim test: 0
Number of HSP's gapped (non-prelim): 7131
length of database: 68,354,980
effective HSP length: 108
effective length of database: 48,403,600
effective search space used: 6582889600
frameshift window, decay const: 40, 0.1
T: 12
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)