Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= Dr_sW_006_C04
(923 letters)
Database: Non-redundant SwissProt sequences
184,735 sequences; 68,354,980 total letters
Score E
Sequences producing significant alignments: (bits) Value
sp|Q9Y6P5|SESN1_HUMAN Sestrin-1 (p53-regulated protein PA26) 143 8e-34
sp|Q9CYP7|SESN3_MOUSE Sestrin-3 139 1e-32
sp|P58006|SESN1_MOUSE Sestrin-1 (p53-regulated protein PA26) 139 1e-32
sp|P58004|SESN2_HUMAN Sestrin-2 (Hi95) 138 2e-32
sp|P58005|SESN3_HUMAN Sestrin-3 137 6e-32
sp|P58043|SESN2_MOUSE Sestrin-2 131 2e-30
sp|P58003|SESN1_XENLA Sestrin-1 (p53-regulated protein PA26... 130 5e-30
sp|Q9W1K5|SEST_DROME Putative sestrin 129 9e-30
sp|Q9N4D6|SEST_CAEEL Putative sestrin 69 2e-11
sp|Q9Y7J8|YGL1_SCHPO Hypothetical protein C216.01c in chrom... 38 0.035
>sp|Q9Y6P5|SESN1_HUMAN Sestrin-1 (p53-regulated protein PA26)
Length = 492
Score = 143 bits (360), Expect = 8e-34
Identities = 91/313 (29%), Positives = 153/313 (48%), Gaps = 14/313 (4%)
Frame = +3
Query: 15 RFYLAIMAAAQMHCKELIYRFITEFIAAGGDPNWLQGLHKAPSRFRPLAVLNQHLCHQPW 194
R Y+ IMAAA+ C L+ + +F+ GGDP WL GL AP + + L LN+ L H+PW
Sbjct: 117 RHYIGIMAAARHQCSYLVNLHVNDFLHVGGDPKWLNGLENAPQKLQNLGELNKVLAHRPW 176
Query: 195 QIEPKNIQQLIHSPKGLFHISMSQLMQAVVIMTHVYSLSSFILVCGINSEID-------H 353
I ++I+ L+ + + + S+++L+ AVV++TH +SL+SF CGI+ EI
Sbjct: 177 LITKEHIEGLLKAEEHSW--SLAELVHAVVLLTHYHSLASFTFGCGISPEIHCDGGHTFR 234
Query: 354 PPALLWY---NSTNSDSSNSLRNTHSTENISLSNSNDVXXXXXXXXXXXXXXXXXXXXQS 524
PP++ Y + TN + S +S EN+S+S+S
Sbjct: 235 PPSVSNYCICDITNGNHSVDEMPVNSAENVSVSDS------------------------- 269
Query: 525 ETDDDKSDENHEDYPLDVLMERLRLAQXXXXXXXXXXXXKMFLSVEKENETIIKNQNHPK 704
+ ++ LME++R Q ++ E++ + +
Sbjct: 270 ------------FFEVEALMEKMRQLQECRDEEEASQEEMASRFEIEKRESMFVFSSDDE 317
Query: 705 EVNP--LIERFIEDPNFTYISYNSNNAEV--LRMQEYSWSDEACCLADRFYTDIGKALED 872
EV P + R ED ++ Y ++ + V R+Q+Y W D L +R Y D+G+ +++
Sbjct: 318 EVTPARAVSRHFEDTSYGYKDFSRHGMHVPTFRVQDYCWEDHGYSLVNRLYPDVGQLIDE 377
Query: 873 KFNCSYDLTYNTM 911
KF+ +Y+LTYNTM
Sbjct: 378 KFHIAYNLTYNTM 390
>sp|Q9CYP7|SESN3_MOUSE Sestrin-3
Length = 492
Score = 139 bits (350), Expect = 1e-32
Identities = 97/308 (31%), Positives = 146/308 (47%), Gaps = 5/308 (1%)
Frame = +3
Query: 3 PYVDRFYLAIMAAAQMHCKELIYRFITEFIAAGGDPNWLQGLHKAPSRFRPLAVLNQHLC 182
P DR Y+AIMAAA+ C LI + EF+ GG WL GL P R R L +N+ L
Sbjct: 104 PLPDRHYIAIMAAARHQCSYLINMHVDEFLKTGGIAEWLNGLEYVPQRLRNLNEINKLLA 163
Query: 183 HQPWQIEPKNIQQLIHSPKGLFHISMSQLMQAVVIMTHVYSLSSFILVCGINSEIDHPPA 362
H+PW I ++IQ+L+ + G + S+ +L+ AVV++ H ++L+SF+ GIN E D P
Sbjct: 164 HRPWLITKEHIQKLVKT--GENNWSLPELVHAVVLLAHYHALASFVFGSGINPERD-PGI 220
Query: 363 LLWYN--STNSDSSNSLRNTHSTENISLSNSNDVXXXXXXXXXXXXXXXXXXXXQSETDD 536
+ S +S L N +S EN SL+ SN Q + +D
Sbjct: 221 ANGFRLISVSSFCVCDLANDNSIENTSLAGSN--FGIVDSLGELEALMERMKRLQEDRED 278
Query: 537 DKSDENHEDYPLDVLMERLRLAQXXXXXXXXXXXXKMFLSVEKENETIIKNQNHPKEVNP 716
D++ + + R + F + E++ I+
Sbjct: 279 DETTR-------EEMTTRFEKEKKESLFVVPGETLHAFPHSDFEDDVIVTAD-------- 323
Query: 717 LIERFIEDPNFTYISYNSNNAEVL---RMQEYSWSDEACCLADRFYTDIGKALEDKFNCS 887
+ R+IEDP+F Y + E L R Q+Y+W + L +R Y+DIG L++KF
Sbjct: 324 -VSRYIEDPSFGYEDFARRGEEHLPTFRAQDYTWENHGFSLVNRLYSDIGHLLDEKFRMV 382
Query: 888 YDLTYNTM 911
Y+LTYNTM
Sbjct: 383 YNLTYNTM 390
>sp|P58006|SESN1_MOUSE Sestrin-1 (p53-regulated protein PA26)
Length = 492
Score = 139 bits (349), Expect = 1e-32
Identities = 90/313 (28%), Positives = 150/313 (47%), Gaps = 14/313 (4%)
Frame = +3
Query: 15 RFYLAIMAAAQMHCKELIYRFITEFIAAGGDPNWLQGLHKAPSRFRPLAVLNQHLCHQPW 194
R Y+ IMAAA+ C L+ +++F+ GGDP WL GL AP + + L LN+ L H+PW
Sbjct: 117 RHYIGIMAAARHQCSYLVNLHVSDFLHVGGDPKWLNGLENAPQKLQNLGELNKVLAHRPW 176
Query: 195 QIEPKNIQQLIHSPKGLFHISMSQLMQAVVIMTHVYSLSSFILVCGINSEID-------H 353
I ++I+ L+ + + + S+++L+ AVV++TH +SL+SF CGI+ EI
Sbjct: 177 LITKEHIEGLLKAEEHSW--SLAELVHAVVLLTHYHSLASFTFGCGISPEIHCDGGHTFR 234
Query: 354 PPALLWY---NSTNSDSSNSLRNTHSTENISLSNSNDVXXXXXXXXXXXXXXXXXXXXQS 524
PP++ Y + TN + S +S N S+S+S
Sbjct: 235 PPSVSNYCICDITNGNHSVDEMQVNSAGNASVSDS------------------------- 269
Query: 525 ETDDDKSDENHEDYPLDVLMERLRLAQXXXXXXXXXXXXKMFLSVEKENETIIKNQNHPK 704
+ ++ LME++R Q ++ E++ +
Sbjct: 270 ------------FFEVEALMEKMRQLQECREEEEASQEEMASRFEMEKRESMFVFSSDDD 317
Query: 705 EVNPL--IERFIEDPNFTYISYNSNNAEV--LRMQEYSWSDEACCLADRFYTDIGKALED 872
EV P + R ED ++ Y ++ + V R+Q+Y W D L +R Y D+G+ +++
Sbjct: 318 EVTPARDVSRHFEDTSYGYKDFSRHGMHVPTFRVQDYCWEDHGYSLVNRLYPDVGQLIDE 377
Query: 873 KFNCSYDLTYNTM 911
KF+ Y+LTYNTM
Sbjct: 378 KFHIPYNLTYNTM 390
>sp|P58004|SESN2_HUMAN Sestrin-2 (Hi95)
Length = 480
Score = 138 bits (347), Expect = 2e-32
Identities = 96/308 (31%), Positives = 146/308 (47%), Gaps = 9/308 (2%)
Frame = +3
Query: 15 RFYLAIMAAAQMHCKELIYRFITEFIAAGGDPNWLQGLHKAPSRFRPLAVLNQHLCHQPW 194
R Y+AIMAAA+ C L+ + EF+ GGDP WL GLH+AP + R L+ +N+ L H+PW
Sbjct: 112 RHYIAIMAAARHQCSYLVGSHMAEFLQTGGDPEWLLGLHRAPEKLRKLSEINKLLAHRPW 171
Query: 195 QIEPKNIQQLIHSPKGLFHISMSQLMQAVVIMTHVYSLSSFILVCGI--NSEIDHPPALL 368
I ++IQ L+ + G S+++L+QA+V++TH +SLSSF+ CGI + D PA
Sbjct: 172 LITKEHIQALLKT--GEHTWSLAELIQALVLLTHCHSLSSFVFGCGILPEGDADGSPAPQ 229
Query: 369 WYNSTNSDSSNSLRNTHSTENISLSNSNDVXXXXXXXXXXXXXXXXXXXXQSETDDDKSD 548
+ SS R+ L+NS +S D
Sbjct: 230 APTPPSEQSSPPSRD-------PLNNSG--------------------GFESARD----- 257
Query: 549 ENHEDYPLDVLMERLRLAQXXXXXXXXXXXXKM--FLSVEKENETIIKNQNHPKEVNPLI 722
++ LMER++ Q +M +EK ++ E +P
Sbjct: 258 -------VEALMERMQQLQESLLRDEGTSQEEMESRFELEKSESLLVTPSADILEPSPHP 310
Query: 723 ER--FIEDPNFTYISYNSNNAE---VLRMQEYSWSDEACCLADRFYTDIGKALEDKFNCS 887
+ F+EDP F Y + A+ R Q+Y+W D L R Y + G+ L++KF +
Sbjct: 311 DMLCFVEDPTFGYEDFTRRGAQAPPTFRAQDYTWEDHGYSLIQRLYPEGGQLLDEKFQAA 370
Query: 888 YDLTYNTM 911
Y LTYNT+
Sbjct: 371 YSLTYNTI 378
>sp|P58005|SESN3_HUMAN Sestrin-3
Length = 492
Score = 137 bits (344), Expect = 6e-32
Identities = 97/308 (31%), Positives = 147/308 (47%), Gaps = 5/308 (1%)
Frame = +3
Query: 3 PYVDRFYLAIMAAAQMHCKELIYRFITEFIAAGGDPNWLQGLHKAPSRFRPLAVLNQHLC 182
PY R Y+AIMAAA+ C LI + EF+ GG WL GL P R + L +N+ L
Sbjct: 106 PY--RHYIAIMAAARHQCSYLINMHVDEFLKTGGIAEWLNGLEYVPQRLKNLNEINKLLA 163
Query: 183 HQPWQIEPKNIQQLIHSPKGLFHISMSQLMQAVVIMTHVYSLSSFILVCGINSEIDHPPA 362
H+PW I ++IQ+L+ + G + S+ +L+ AVV++ H ++L+SF+ GIN E D P
Sbjct: 164 HRPWLITKEHIQKLVKT--GENNWSLPELVHAVVLLAHYHALASFVFGSGINPERD-PEI 220
Query: 363 LLWYN--STNSDSSNSLRNTHSTENISLSNSNDVXXXXXXXXXXXXXXXXXXXXQSETDD 536
+ S N+ L N ++ EN SLS SN Q E +D
Sbjct: 221 SNGFRLISVNNFCVCDLANDNNIENASLSGSN--FGIVDSLSELEALMERMKRLQEERED 278
Query: 537 DKSDENHEDYPLDVLMERLRLAQXXXXXXXXXXXXKMFLSVEKENETIIKNQNHPKEVNP 716
+++ + + + R + F + E++ II +
Sbjct: 279 EEASQ-------EEMSTRFEKEKKESLFVVSGDTFHSFPHSDFEDDMIITSD-------- 323
Query: 717 LIERFIEDPNFTYISYNSNNAEVL---RMQEYSWSDEACCLADRFYTDIGKALEDKFNCS 887
+ R+IEDP F Y + E L R Q+Y+W + L +R Y+DIG L++KF
Sbjct: 324 -VSRYIEDPGFGYEDFARRGEEHLPTFRAQDYTWENHGFSLVNRLYSDIGHLLDEKFRMV 382
Query: 888 YDLTYNTM 911
Y+LTYNTM
Sbjct: 383 YNLTYNTM 390
>sp|P58043|SESN2_MOUSE Sestrin-2
Length = 480
Score = 131 bits (330), Expect = 2e-30
Identities = 94/306 (30%), Positives = 148/306 (48%), Gaps = 7/306 (2%)
Frame = +3
Query: 15 RFYLAIMAAAQMHCKELIYRFITEFIAAGGDPNWLQGLHKAPSRFRPLAVLNQHLCHQPW 194
R Y+AIMAAA+ C L+ +TEF+ GGDP WL GLH+AP + R L+ +N+ L H+PW
Sbjct: 112 RHYIAIMAAARHQCSYLVGSHMTEFLQTGGDPEWLLGLHRAPEKLRKLSEVNKLLAHRPW 171
Query: 195 QIEPKNIQQLIHSPKGLFHISMSQLMQAVVIMTHVYSLSSFILVCGINSEIDHPPALLWY 374
I ++IQ L+ + G S+++L+QA+V++TH +SL+SF+ CGI E D +
Sbjct: 172 LITKEHIQALLKT--GEHSWSLAELIQALVLLTHCHSLASFVFGCGILPEGDAEGS---- 225
Query: 375 NSTNSDSSNSLRNTHSTENISLSNSNDVXXXXXXXXXXXXXXXXXXXXQSETDDDKSDEN 554
++ + S S + T + + L+NS ++ D
Sbjct: 226 PASQAPSPPSEQGTPPSGD-PLNNSG--------------------GFEAARD------- 257
Query: 555 HEDYPLDVLMERLRLAQXXXXXXXXXXXXKM--FLSVEKENETIIKNQNHPKEVNPL--I 722
++ LMER+R Q +M +EK ++ E +P I
Sbjct: 258 -----VEALMERMRQLQESLLRDEGASQEEMENRFELEKSESLLVTPSADILEPSPHPDI 312
Query: 723 ERFIEDPNFTYISYNSNNAE---VLRMQEYSWSDEACCLADRFYTDIGKALEDKFNCSYD 893
F+EDP F Y + + R Q+Y+W D L R Y + G+ L++KF +
Sbjct: 313 LCFVEDPAFGYEDFTRRGTQAPPTFRAQDYTWEDHGYSLIQRLYPEGGQLLDEKFQVACS 372
Query: 894 LTYNTM 911
LTYNT+
Sbjct: 373 LTYNTI 378
>sp|P58003|SESN1_XENLA Sestrin-1 (p53-regulated protein PA26) (XPA26)
Length = 481
Score = 130 bits (327), Expect = 5e-30
Identities = 86/306 (28%), Positives = 140/306 (45%), Gaps = 9/306 (2%)
Frame = +3
Query: 21 YLAIMAAAQMHCKELIYRFITEFIAAGGDPNWLQGLHKAPSRFRPLAVLNQHLCHQPWQI 200
Y+ IMAA++ C L+ + +FI GGD WL GL AP + R L LN+ L H+PW I
Sbjct: 111 YIGIMAASRHQCSYLVNLHVNDFIHHGGDQKWLNGLENAPQKLRNLGELNKMLAHRPWLI 170
Query: 201 EPKNIQQLIHSPKGLFHISMSQLMQAVVIMTHVYSLSSFILVCGINSEID-------HPP 359
++I+QL+ + G S+++L+ A+V++ H +SL+SF CGIN EI PP
Sbjct: 171 TKEHIKQLLKA--GEHSWSLAELIHAIVLLAHYHSLASFTFGCGINPEIHSNGGHTFRPP 228
Query: 360 ALLWYNSTNSDSSNSLRNTHSTENISLSNSNDVXXXXXXXXXXXXXXXXXXXXQSETDDD 539
++ Y + + N H I + + + +
Sbjct: 229 SVSNYCICDITNGNHGTEGHLPVGIVMPTDS------------TCEVEALMVKMKQLQEG 276
Query: 540 KSDENHEDYPLDVLMERLRLAQXXXXXXXXXXXXKMFLSVEKENETIIKNQNHPKEVNPL 719
+ +E + ER + M S E E+ P +++
Sbjct: 277 RDEEEASQEEMATRFEREK-------------TESMVFSTEDEDP--------PPDID-- 313
Query: 720 IERFIEDPNFTYISYNSNNAEV--LRMQEYSWSDEACCLADRFYTDIGKALEDKFNCSYD 893
+ R ED ++ Y ++ V R+Q+YSW D L +R Y D+G+ L++KF+ +Y+
Sbjct: 314 VSRHFEDTSYGYKDFSRRGMHVPTFRVQDYSWEDHGYSLVNRLYPDVGQLLDEKFHIAYN 373
Query: 894 LTYNTM 911
LTYNTM
Sbjct: 374 LTYNTM 379
>sp|Q9W1K5|SEST_DROME Putative sestrin
Length = 497
Score = 129 bits (325), Expect = 9e-30
Identities = 90/327 (27%), Positives = 148/327 (45%), Gaps = 27/327 (8%)
Frame = +3
Query: 15 RFYLAIMAAAQMHCKELIYRFITEFIAAGGDPNWLQGLHKAPSRFRPLAVLNQHLCHQPW 194
R+YLAI+AAA+ C L+ R+ EFI GGD WL GL P++ R + +N+ L H+PW
Sbjct: 73 RYYLAIIAAARHQCPYLVKRYEKEFINQGGDSAWLGGLDFIPAKLRAIYDINKILAHRPW 132
Query: 195 QIEPKNIQQLIHSPKGLFHISMSQLMQAVVIMTHVYSLSSFILVCGINSEID-------- 350
+ ++I++L KG S+S+++ A+V+++H +SLSSF+ CG+ ++D
Sbjct: 133 LLRKEHIERL---TKGKNSWSLSEVVHAMVLLSHFHSLSSFVFSCGLTQKLDGLSSPKLK 189
Query: 351 HPPALLWYNS-----TNSDSSNSLRNTHSTENISLSNSNDVXXXXXXXXXXXXXXXXXXX 515
PPA + + T + + + ISL+N+N
Sbjct: 190 SPPAAVAALAPTILITPTSPTEPQKGKPVLAEISLNNANPDYDSQTAASSNGGAPPDSAN 249
Query: 516 XQSETDDDKSDENH----------EDYPLDVLMERLRLAQXXXXXXXXXXXXKMFLSVEK 665
++ D + + ++ LMER+++ F VE+
Sbjct: 250 AVADGPDATTLNGYLATAQQLPQQHGISVETLMERMKVLSQKQDECSEAELSSRFQKVEQ 309
Query: 666 EN-ETIIKNQNHPKEVNPLIERFIEDPNFTYISYNSNNAE---VLRMQEYSWSDEACCLA 833
+ E V + +++D NF Y + E R+Q+YSW D L
Sbjct: 310 QTAELAAVTPEAAVGVPTNLSHYVDDANFIYQDFARRGTESINTFRIQDYSWEDHGYSLV 369
Query: 834 DRFYTDIGKALEDKFNCSYDLTYNTMG 914
D Y D+G L+ KF +Y+LTY TMG
Sbjct: 370 DGLYNDVGIFLDAKFRAAYNLTYCTMG 396
>sp|Q9N4D6|SEST_CAEEL Putative sestrin
Length = 517
Score = 68.9 bits (167), Expect = 2e-11
Identities = 41/119 (34%), Positives = 62/119 (52%), Gaps = 3/119 (2%)
Frame = +3
Query: 3 PYVDRFYLAIMAAAQMHCKELIYRFITEFIAAGGDPNWLQGLHKAPSRFRPLAVLNQHLC 182
P R YLA+MAA++ C L+ +F+ GG WL G+ + +FR L LN+ LC
Sbjct: 115 PASARHYLALMAASRHRCLSLMDHHRRKFLEKGGQQMWLLGIDWSYMKFRKLDYLNRMLC 174
Query: 183 HQPWQIEPKNIQQLI--HSPK-GLFHISMSQLMQAVVIMTHVYSLSSFILVCGINSEID 350
H+PW I KN+ L +P G S+ L AV IM+ +++ + I G+ +D
Sbjct: 175 HRPWMIHWKNLAVLFARRTPDGGPAFFSVCSLHHAVGIMSMTHAMCTVICCIGLERRVD 233
>sp|Q9Y7J8|YGL1_SCHPO Hypothetical protein C216.01c in chromosome II
Length = 836
Score = 38.1 bits (87), Expect = 0.035
Identities = 33/94 (35%), Positives = 46/94 (48%), Gaps = 16/94 (17%)
Frame = +3
Query: 213 IQQLIHSPKGLFHISMSQLMQAVV----------IMTH----VYSLSSFILVCGINSEID 350
IQQ+ + KGL S S L V M+H V + S ILV S ID
Sbjct: 373 IQQVCNIAKGLQFQSCSALFATFVKFNLLKALDYAMSHENNSVRNAGSDILV----SIID 428
Query: 351 HPPALLW--YNSTNSDSSNSLRNTHSTENISLSN 446
H PA++W ++ D+S+SL N H +++ LSN
Sbjct: 429 HEPAIVWQKFDQDRKDASSSLSNAHVSQHSLLSN 462
Database: Non-redundant SwissProt sequences
Posted date: Dec 6, 2005 7:40 AM
Number of letters in database: 68,354,980
Number of sequences in database: 184,735
Database: swissprot.01
Posted date: Dec 6, 2005 8:18 AM
Number of letters in database: 66,202,850
Number of sequences in database: 184,431
Lambda K H
0.318 0.134 0.401
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 87,638,311
Number of Sequences: 369166
Number of extensions: 1610795
Number of successful extensions: 4300
Number of sequences better than 10.0: 10
Number of HSP's better than 10.0 without gapping: 4047
Number of HSP's successfully gapped in prelim test: 0
Number of HSP's that attempted gapping in prelim test: 0
Number of HSP's gapped (non-prelim): 4283
length of database: 68,354,980
effective HSP length: 110
effective length of database: 48,034,130
effective search space used: 9462723610
frameshift window, decay const: 40, 0.1
T: 12
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)