Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= Dr_sW_006_B14
(953 letters)
Database: Non-redundant SwissProt sequences
184,735 sequences; 68,354,980 total letters
Score E
Sequences producing significant alignments: (bits) Value
sp|Q25464|FP2_MYTGA Adhesive plaque matrix protein 2 precur... 65 2e-10
sp|P07207|NOTCH_DROME Neurogenic locus Notch protein precursor 62 2e-09
sp|P24014|SLIT_DROME Slit protein precursor [Contains: Slit... 60 1e-08
sp|P13508|GLP1_CAEEL Glp-1 protein precursor 59 2e-08
sp|P46530|NOTC1_BRARE Neurogenic locus notch homolog protei... 59 3e-08
sp|P21783|NOTCH_XENLA Neurogenic locus notch protein homolo... 58 3e-08
sp|P18168|SERR_DROME Serrate protein precursor (Beaded prot... 58 3e-08
sp|Q63722|JAG1_RAT Jagged-1 precursor (Jagged1) 57 6e-08
sp|Q9QXX0|JAG1_MOUSE Jagged-1 precursor (Jagged1) 57 8e-08
sp|P14585|LIN12_CAEEL Lin-12 protein precursor 55 3e-07
>sp|Q25464|FP2_MYTGA Adhesive plaque matrix protein 2 precursor (Foot protein 2) (MGFP2)
(MGFP-2)
Length = 473
Score = 65.5 bits (158), Expect = 2e-10
Identities = 48/158 (30%), Positives = 68/158 (43%), Gaps = 7/158 (4%)
Frame = +3
Query: 303 ECEPNYYPPKQCTTFCFP--IENEYSC--DGFGNKICREGLYYNAQESKCLKNNCISSNI 470
EC P Y+ P+ C P +N C DG G CR Y+ C N C +
Sbjct: 218 ECRPGYFGPECERYVCAPNPCKNGGICSSDGSGGYRCRCKGGYSGPT--CKVNVCKPT-- 273
Query: 471 QCQNNGYCINNGLTYECKCLDSYIGKLCEKXXXXXXXXXXXXGKCFVQNHGDKLYACSCS 650
C+N+G C+N G +Y C C Y G C + G+C+ N D + C C
Sbjct: 274 PCKNSGRCVNKGSSYNCICKGGYSGPTCGE-NVCKPNPCQNRGRCYPDNSDDG-FKCRCV 331
Query: 651 EGFTGEKCDLRIYQPC---ICPKNMKCNYSESGALFSC 755
G+ G C+ + PC C KCNY +G +++C
Sbjct: 332 GGYKGPTCEDK-PNPCNTKPCKNGGKCNY--NGKIYTC 366
Score = 65.1 bits (157), Expect = 3e-10
Identities = 41/126 (32%), Positives = 56/126 (44%), Gaps = 1/126 (0%)
Frame = +3
Query: 348 CFPIENEYSCDGFGNKICREGLY-YNAQESKCLKNNCISSNIQCQNNGYCINNGLTYECK 524
C P Y C C+ G Y YN LKN C + QC+N C+ G T++C
Sbjct: 60 CKPRGGSYKC------FCKGGYYGYNCN----LKNACKPN--QCKNKSRCVPVGKTFKCV 107
Query: 525 CLDSYIGKLCEKXXXXXXXXXXXXGKCFVQNHGDKLYACSCSEGFTGEKCDLRIYQPCIC 704
C + G+LCEK GKC G Y C+CS G+TG +C++ +P C
Sbjct: 108 CRNGNFGRLCEK-NVCSPNPCKNNGKC--SPLGKTGYKCTCSGGYTGPRCEVHACKPNPC 164
Query: 705 PKNMKC 722
+C
Sbjct: 165 KNKGRC 170
Score = 58.2 bits (139), Expect = 3e-08
Identities = 43/147 (29%), Positives = 60/147 (40%), Gaps = 8/147 (5%)
Frame = +3
Query: 306 CEPNYYPPKQCTTFC--FPIENEYSCDGFG---NKICREGLYYNAQESKCLKNNCISSNI 470
C+ Y P C P +N C G N IC+ G C +N C +
Sbjct: 256 CKGGYSGPTCKVNVCKPTPCKNSGRCVNKGSSYNCICKGGY----SGPTCGENVCKPN-- 309
Query: 471 QCQNNGYCI--NNGLTYECKCLDSYIGKLCE-KXXXXXXXXXXXXGKCFVQNHGDKLYAC 641
CQN G C N+ ++C+C+ Y G CE K GKC N+ K+Y C
Sbjct: 310 PCQNRGRCYPDNSDDGFKCRCVGGYKGPTCEDKPNPCNTKPCKNGGKC---NYNGKIYTC 366
Query: 642 SCSEGFTGEKCDLRIYQPCICPKNMKC 722
C+ G+ G C + Y+P C + C
Sbjct: 367 KCAYGWRGRHCTDKAYKPNPCVVSKPC 393
Score = 57.4 bits (137), Expect = 6e-08
Identities = 42/149 (28%), Positives = 57/149 (38%), Gaps = 4/149 (2%)
Frame = +3
Query: 306 CEPNYYPPKQCTTF--CFPI-ENEYSCDGFGNKICREGLYYNAQESKCLKNNCISSNIQC 476
CE N P C C P+ + Y C C G E K N C
Sbjct: 117 CEKNVCSPNPCKNNGKCSPLGKTGYKCT------CSGGYTGPRCEVHACKPN------PC 164
Query: 477 QNNGYCINNGLT-YECKCLDSYIGKLCEKXXXXXXXXXXXXGKCFVQNHGDKLYACSCSE 653
+N G C +G T Y+C+C+D Y G C++ G C GD Y+C C
Sbjct: 165 KNKGRCFPDGKTGYKCRCVDGYSGPTCQENACKPNPCSNG-GTCSADKFGD--YSCECRP 221
Query: 654 GFTGEKCDLRIYQPCICPKNMKCNYSESG 740
G+ G +C+ + P C C+ SG
Sbjct: 222 GYFGPECERYVCAPNPCKNGGICSSDGSG 250
Score = 55.1 bits (131), Expect = 3e-07
Identities = 39/127 (30%), Positives = 51/127 (40%), Gaps = 8/127 (6%)
Frame = +3
Query: 327 PKQCTTFCFPIENEYSCDGFGNKI----CREGLYYNAQESKCLKNNCISSNIQCQNNGYC 494
P C T P +N C+ + KI C G K K N + C+N G C
Sbjct: 343 PNPCNTK--PCKNGGKCN-YNGKIYTCKCAYGWRGRHCTDKAYKPNPCVVSKPCKNRGKC 399
Query: 495 INNGLTYECKCLDSYIGKLCE----KXXXXXXXXXXXXGKCFVQNHGDKLYACSCSEGFT 662
I NG Y CKC Y G+ C K GKC + +G Y C C+ G++
Sbjct: 400 IWNGKAYRCKCAYGYGGRHCTKKSYKKNPCASRPCKNRGKCTDKGNG---YVCKCARGYS 456
Query: 663 GEKCDLR 683
G C L+
Sbjct: 457 GRYCSLK 463
Score = 44.7 bits (104), Expect = 4e-04
Identities = 25/93 (26%), Positives = 34/93 (36%)
Frame = +3
Query: 447 NNCISSNIQCQNNGYCINNGLTYECKCLDSYIGKLCEKXXXXXXXXXXXXGKCFVQNHGD 626
N C+ C+ NG C G +Y+C C Y G C +C
Sbjct: 47 NPCLKK--PCKYNGVCKPRGGSYKCFCKGGYYGYNCNLKNACKPNQCKNKSRCVPVG--- 101
Query: 627 KLYACSCSEGFTGEKCDLRIYQPCICPKNMKCN 725
K + C C G G C+ + P C N KC+
Sbjct: 102 KTFKCVCRNGNFGRLCEKNVCSPNPCKNNGKCS 134
>sp|P07207|NOTCH_DROME Neurogenic locus Notch protein precursor
Length = 2703
Score = 62.4 bits (150), Expect = 2e-09
Identities = 53/198 (26%), Positives = 77/198 (38%), Gaps = 5/198 (2%)
Frame = +3
Query: 354 PIENEYSC-DGFGNKICREGLYYNAQESKCLKNNCISSNIQCQNNGYCINNGLTYECKCL 530
P NE C DG IC Y + + + C S+ CQ+ G C + + C+C+
Sbjct: 761 PCVNEGRCEDGINEFICHCPPGYTGKRCELDIDECSSN--PCQHGGTCYDKLNAFSCQCM 818
Query: 531 DSYIGKLCE-KXXXXXXXXXXXXGKCFVQNHGDKLYACSCSEGFTGEKCDLRIYQPCI-- 701
Y G+ CE G C + +G Y C C FTG C+ ++ PC
Sbjct: 819 PGYTGQKCETNIDDCVTNPCGNGGTCIDKVNG---YKCVCKVPFTGRDCESKM-DPCASN 874
Query: 702 -CPKNMKCNYSESGALFSCTSENEADSSNPKSDYSNRKVKQNWKDVSLSTTIVAAVGCMT 878
C KC S + FSCT K Y+ R ++ + SLS+ C+
Sbjct: 875 RCKNEAKCTPSSNFLDFSCTC---------KLGYTGRYCDEDIDECSLSSPCRNGASCLN 925
Query: 879 ILISIGVSIYVCHRTRSY 932
+ S Y C T+ Y
Sbjct: 926 VPGS-----YRCLCTKGY 938
Score = 56.6 bits (135), Expect = 1e-07
Identities = 38/124 (30%), Positives = 48/124 (38%)
Frame = +3
Query: 303 ECEPNYYPPKQCTTFCFPIENEYSCDGFGNKICREGLYYNAQESKCLKNNCISSNIQCQN 482
EC+ N P + C Y C +C G Y ++ C S CQN
Sbjct: 220 ECQSN---PCKYGGTCVNTHGSYQC------MCPTG--YTGKDCDTKYKPCSPS--PCQN 266
Query: 483 NGYCINNGLTYECKCLDSYIGKLCEKXXXXXXXXXXXXGKCFVQNHGDKLYACSCSEGFT 662
G C +NGL+YECKC + GK CE+ G + D Y C C FT
Sbjct: 267 GGICRSNGLSYECKCPKGFEGKNCEQNYDDCLGHLCQNGGTCIDGISD--YTCRCPPNFT 324
Query: 663 GEKC 674
G C
Sbjct: 325 GRFC 328
Score = 50.1 bits (118), Expect = 9e-06
Identities = 39/152 (25%), Positives = 57/152 (37%), Gaps = 5/152 (3%)
Frame = +3
Query: 366 EYSCDGFGNKICREGLYYNAQESKCLKNNCISSNIQCQNNGYC--INNGLTYECKCLDSY 539
EY+C C G Y + + KN C SS C+N C + ++ C C +
Sbjct: 161 EYTC------ACANG--YTGERCET-KNLCASS--PCRNGATCTALAGSSSFTCSCPPGF 209
Query: 540 IGKLCEKXXXXXXXXXXXXGKCFVQNHGDKLYACSCSEGFTGEKCDLRIYQPCI---CPK 710
G C G V HG Y C C G+TG+ CD + Y+PC C
Sbjct: 210 TGDTCSYDIEECQSNPCKYGGTCVNTHGS--YQCMCPTGYTGKDCDTK-YKPCSPSPCQN 266
Query: 711 NMKCNYSESGALFSCTSENEADSSNPKSDYSN 806
C +G + C + N + +Y +
Sbjct: 267 GGICR--SNGLSYECKCPKGFEGKNCEQNYDD 296
Score = 49.7 bits (117), Expect = 1e-05
Identities = 32/109 (29%), Positives = 45/109 (41%), Gaps = 2/109 (1%)
Frame = +3
Query: 354 PIENEYSCDGFGNKI-CREGLYYNAQESKCLKNNCISSNIQCQNNGYCINNGLTYECKCL 530
P +N +C + N C L ++ + +C S+ C N G CI+ Y C CL
Sbjct: 992 PCQNGATCSQYVNSYTCTCPLGFSGINCQTNDEDCTESS--CLNGGSCIDGINGYNCSCL 1049
Query: 531 DSYIGKLCE-KXXXXXXXXXXXXGKCFVQNHGDKLYACSCSEGFTGEKC 674
Y G C+ K C QN+ Y C C GFTG++C
Sbjct: 1050 AGYSGANCQYKLNKCDSNPCLNGATCHEQNNE---YTCHCPSGFTGKQC 1095
Score = 49.7 bits (117), Expect = 1e-05
Identities = 35/120 (29%), Positives = 44/120 (36%)
Frame = +3
Query: 339 TTFCFPIENEYSCDGFGNKICREGLYYNAQESKCLKNNCISSNIQCQNNGYCINNGLTYE 518
T C + N Y C+ CR G E K + C S CQN G C +
Sbjct: 1311 TLDCVQLVNNYHCN------CRPGHMGRHCEHKV--DFCAQS--PCQNGGNCNIRQSGHH 1360
Query: 519 CKCLDSYIGKLCEKXXXXXXXXXXXXGKCFVQNHGDKLYACSCSEGFTGEKCDLRIYQPC 698
C C + + GK CE G C V + G Y C C G GE C++ C
Sbjct: 1361 CICNNGFYGKNCELSGQDCDSNPCRVGNCVVADEGFG-YRCECPRGTLGEHCEIDTLDEC 1419
Score = 48.5 bits (114), Expect = 3e-05
Identities = 30/109 (27%), Positives = 43/109 (39%)
Frame = +3
Query: 348 CFPIENEYSCDGFGNKICREGLYYNAQESKCLKNNCISSNIQCQNNGYCINNGLTYECKC 527
C + Y C +C +G Y ++ ++C S CQN G C++ Y C C
Sbjct: 923 CLNVPGSYRC------LCTKG--YEGRDCAINTDDCAS--FPCQNGGTCLDGIGDYSCLC 972
Query: 528 LDSYIGKLCEKXXXXXXXXXXXXGKCFVQNHGDKLYACSCSEGFTGEKC 674
+D + GK CE G Q Y C+C GF+G C
Sbjct: 973 VDGFDGKHCETDINECLSQPCQNGATCSQYVNS--YTCTCPLGFSGINC 1019
Score = 48.1 bits (113), Expect = 4e-05
Identities = 37/148 (25%), Positives = 61/148 (41%), Gaps = 18/148 (12%)
Frame = +3
Query: 297 EHECE-PNYYPPKQCTTF--------------CFPIENEYSCD---GFGNKICREGLYYN 422
E+ C P+ + KQC+ + C +++++SC G+ K+C + +
Sbjct: 1081 EYTCHCPSGFTGKQCSEYVDWCGQSPCENGATCSQMKHQFSCKCSAGWTGKLC-DVQTIS 1139
Query: 423 AQESKCLKNNCISSNIQCQNNGYCINNGLTYECKCLDSYIGKLCEKXXXXXXXXXXXXGK 602
Q++ K + Q NNG C + G ++ C C Y G C+K G
Sbjct: 1140 CQDAADRKGLSLR---QLCNNGTCKDYGNSHVCYCSQGYAGSYCQKEIDECQSQPCQNGG 1196
Query: 603 CFVQNHGDKLYACSCSEGFTGEKCDLRI 686
G Y C C +GF G+ C+L I
Sbjct: 1197 TCRDLIG--AYECQCRQGFQGQNCELNI 1222
Score = 47.8 bits (112), Expect = 5e-05
Identities = 38/144 (26%), Positives = 53/144 (36%), Gaps = 10/144 (6%)
Frame = +3
Query: 354 PIENEYSCD---GFGNKICREGLYYNAQESKCLKNNCISSNIQCQNNGYCINNGLTYECK 524
PI Y+C G+ C E + Q S C ++NG C+N +Y C
Sbjct: 428 PINGSYACSCATGYKGVDCSEDIDECDQGSPC------------EHNGICVNTPGSYRCN 475
Query: 525 CLDSYIGKLCEKXXXXXXXXXXXXGKCFVQNHGDKL-----YACSCSEGFTGEKCDLRI- 686
C + G CE QN G L + C C GFTG +C++ I
Sbjct: 476 CSQGFTGPRCETNINECESHP-------CQNEGSCLDDPGTFRCVCMPGFTGTQCEIDID 528
Query: 687 -YQPCICPKNMKCNYSESGALFSC 755
Q C + C+ +G SC
Sbjct: 529 ECQSNPCLNDGTCHDKINGFKCSC 552
Score = 45.4 bits (106), Expect = 2e-04
Identities = 25/82 (30%), Positives = 35/82 (42%), Gaps = 3/82 (3%)
Frame = +3
Query: 462 SNIQCQNNGYCIN--NGLTYECKCLDSYIGKLCEKXXXXXXXXXXXXGKCFVQ-NHGDKL 632
+++ CQN G C+ NG TY C C Y+G CE G C V +G
Sbjct: 63 TSVGCQNGGTCVTQLNGKTY-CACDSHYVGDYCEHRNPCNSMRCQNGGTCQVTFRNGRPG 121
Query: 633 YACSCSEGFTGEKCDLRIYQPC 698
+C C GF C++ + C
Sbjct: 122 ISCKCPLGFDESLCEIAVPNAC 143
Score = 45.1 bits (105), Expect = 3e-04
Identities = 38/139 (27%), Positives = 53/139 (38%), Gaps = 5/139 (3%)
Frame = +3
Query: 300 HECEPNYYPPKQCTTFCFPIENEYSCDGFGNKICREGLYYNAQESKCLKNNCISSNIQCQ 479
+ECE N P Q C Y C C+ G + + + N C S+ C
Sbjct: 641 NECESN---PCQFDGHCQDRVGSYYCQ------CQAGT--SGKNCEVNVNECHSN--PCN 687
Query: 480 NNGYCINNGLTYECKCLDSYIGKLCEK-XXXXXXXXXXXXGKCFVQNHGDKLYACSCSEG 656
N CI+ +Y+C+C+ + G+ CEK G C Q +G Y C C G
Sbjct: 688 NGATCIDGINSYKCQCVPGFTGQHCEKNVDECISSPCANNGVCIDQVNG---YKCECPRG 744
Query: 657 FTGEKC----DLRIYQPCI 701
F C D PC+
Sbjct: 745 FYDAHCLSDVDECASNPCV 763
Score = 45.1 bits (105), Expect = 3e-04
Identities = 34/123 (27%), Positives = 49/123 (39%), Gaps = 6/123 (4%)
Frame = +3
Query: 348 CFPIEN--EYSCDGFGNKICREGLYYNAQESKCLKNNCISSNIQCQNNGYCINNGLTYEC 521
C P N ++SC K+ G Y + +C S + C+N C+N +Y C
Sbjct: 882 CTPSSNFLDFSCTC---KLGYTGRYCDEDIDEC------SLSSPCRNGASCLNVPGSYRC 932
Query: 522 KCLDSYIGKLCEKXXXXXXXXXXXXGKCFVQNHGDKLYACSCSEGFTGEKCDLRI----Y 689
C Y G+ C G + GD Y+C C +GF G+ C+ I
Sbjct: 933 LCTKGYEGRDCAINTDDCASFPCQNGGTCLDGIGD--YSCLCVDGFDGKHCETDINECLS 990
Query: 690 QPC 698
QPC
Sbjct: 991 QPC 993
Score = 44.3 bits (103), Expect = 5e-04
Identities = 32/104 (30%), Positives = 40/104 (38%), Gaps = 4/104 (3%)
Frame = +3
Query: 429 ESKC---LKNNCISSNIQCQNNGYCINNGLT-YECKCLDSYIGKLCEKXXXXXXXXXXXX 596
ES C + N C ++ C N G C L Y C C + Y G+ CE
Sbjct: 132 ESLCEIAVPNAC--DHVTCLNGGTCQLKTLEEYTCACANGYTGERCETKNLCASSPCRNG 189
Query: 597 GKCFVQNHGDKLYACSCSEGFTGEKCDLRIYQPCICPKNMKCNY 728
C G + CSC GFTG+ C I + C N C Y
Sbjct: 190 ATCTALA-GSSSFTCSCPPGFTGDTCSYDIEE---CQSN-PCKY 228
Score = 44.3 bits (103), Expect = 5e-04
Identities = 36/131 (27%), Positives = 46/131 (35%), Gaps = 10/131 (7%)
Frame = +3
Query: 312 PNYYPPKQCTTFCFPIENEYSCDGFGNKICRE-GLYYNAQESKCLKNNCISSNIQ----- 473
P Y K C T P C G ICR GL Y + K + N
Sbjct: 244 PTGYTGKDCDTKYKPCSPS-PCQNGG--ICRSNGLSYECKCPKGFEGKNCEQNYDDCLGH 300
Query: 474 -CQNNGYCINNGLTYECKCLDSYIGKLCE---KXXXXXXXXXXXXGKCFVQNHGDKLYAC 641
CQN G CI+ Y C+C ++ G+ C+ G HG Y+C
Sbjct: 301 LCQNGGTCIDGISDYTCRCPPNFTGRFCQDDVDECAQRDHPVCQNGATCTNTHGS--YSC 358
Query: 642 SCSEGFTGEKC 674
C G+ G C
Sbjct: 359 ICVNGWAGLDC 369
Score = 43.1 bits (100), Expect = 0.001
Identities = 31/120 (25%), Positives = 46/120 (38%), Gaps = 5/120 (4%)
Frame = +3
Query: 354 PIENEYSC-DGFGNKICREGLYYNAQESKCLKNNCISSNIQCQNNGYCINNGLTYECKCL 530
P N+ +C D C L + + ++C S C+N G C ++ Y C+C
Sbjct: 534 PCLNDGTCHDKINGFKCSCALGFTGARCQINIDDCQSQ--PCRNRGICHDSIAGYSCECP 591
Query: 531 DSYIGKLCEKXXXXXXXXXXXXGKCFVQNHGDKLYACSCSEGFTGEKCDLRIYQ----PC 698
Y G CE GKC + + C C G+TG C +I + PC
Sbjct: 592 PGYTGTSCEININDCDSNPCHRGKCIDDVNS---FKCLCDPGYTGYICQKQINECESNPC 648
Score = 43.1 bits (100), Expect = 0.001
Identities = 30/109 (27%), Positives = 41/109 (37%), Gaps = 2/109 (1%)
Frame = +3
Query: 363 NEYSC-DGFGNKICREGLYYNAQESKCLKNNCISSNIQCQNNGYCINNGLTYECKCLDSY 539
N SC DG C Y+ + N C S+ C N C Y C C +
Sbjct: 1033 NGGSCIDGINGYNCSCLAGYSGANCQYKLNKCDSN--PCLNGATCHEQNNEYTCHCPSGF 1090
Query: 540 IGKLCEKXXXXXXXXXXXXG-KCFVQNHGDKLYACSCSEGFTGEKCDLR 683
GK C + G C H ++C CS G+TG+ CD++
Sbjct: 1091 TGKQCSEYVDWCGQSPCENGATCSQMKH---QFSCKCSAGWTGKLCDVQ 1136
Score = 41.6 bits (96), Expect = 0.003
Identities = 28/110 (25%), Positives = 45/110 (40%), Gaps = 5/110 (4%)
Frame = +3
Query: 444 KNNCISSNIQCQNNGYC---INNGLT-YECKCLDSYIGKLCEKXXXXXXXXXXXXGKCFV 611
+N C ++++CQN G C NG CKC + LCE
Sbjct: 97 RNPC--NSMRCQNGGTCQVTFRNGRPGISCKCPLGFDESLCEIAVPNACDHVTCLNGGTC 154
Query: 612 QNHGDKLYACSCSEGFTGEKCDLR-IYQPCICPKNMKCNYSESGALFSCT 758
Q + Y C+C+ G+TGE+C+ + + C C + F+C+
Sbjct: 155 QLKTLEEYTCACANGYTGERCETKNLCASSPCRNGATCTALAGSSSFTCS 204
Score = 41.6 bits (96), Expect = 0.003
Identities = 24/81 (29%), Positives = 36/81 (44%), Gaps = 3/81 (3%)
Frame = +3
Query: 447 NNCISSNIQCQNNGY--CINNGLTYECKCLDSYIGKLCE-KXXXXXXXXXXXXGKCFVQN 617
N C+S+ C N G C+ Y C C ++G+ CE K G C ++
Sbjct: 1299 NECLSN--PCSNAGTLDCVQLVNNYHCNCRPGHMGRHCEHKVDFCAQSPCQNGGNCNIRQ 1356
Query: 618 HGDKLYACSCSEGFTGEKCDL 680
G + C C+ GF G+ C+L
Sbjct: 1357 SG---HHCICNNGFYGKNCEL 1374
Score = 40.8 bits (94), Expect = 0.006
Identities = 44/172 (25%), Positives = 57/172 (33%), Gaps = 13/172 (7%)
Frame = +3
Query: 303 ECEPNYYPPKQCTTFCFPIENEYSCDGFGNKICREGLYYNAQESKCLKNNCISSNIQCQN 482
EC +P Q C YSC IC G C N C
Sbjct: 334 ECAQRDHPVCQNGATCTNTHGSYSC------ICVNGW----AGLDCSNNTDDCKQAACFY 383
Query: 483 NGYCINNGLTYECKCLDSYIGKLCEKXXXXXXXXXXXXGKCFVQNHGDKLYACSCSEGFT 662
CI+ ++ C+C G LC C YACSC+ G+
Sbjct: 384 GATCIDGVGSFYCQCTKGKTGLLCHLDDACTSNPCHADAICDTSPINGS-YACSCATGYK 442
Query: 663 GEKCDLRIYQ-----PC----IC---PKNMKCNYSESGALFSC-TSENEADS 779
G C I + PC IC P + +CN S+ C T+ NE +S
Sbjct: 443 GVDCSEDIDECDQGSPCEHNGICVNTPGSYRCNCSQGFTGPRCETNINECES 494
Score = 40.0 bits (92), Expect = 0.010
Identities = 24/98 (24%), Positives = 34/98 (34%), Gaps = 2/98 (2%)
Frame = +3
Query: 474 CQNNGYCINNGLTYECKCLDSYIGKLCEKXXXXXXXXXXXXGKCFVQNHGDKLYACSCSE 653
C NNG CI+ +EC C ++G CE Y C+C
Sbjct: 1268 CHNNGSCIDRVGGFECVCQPGFVGARCEGDINECLSNPCSNAGTLDCVQLVNNYHCNCRP 1327
Query: 654 GFTGEKCDLRI--YQPCICPKNMKCNYSESGALFSCTS 761
G G C+ ++ C CN +SG C +
Sbjct: 1328 GHMGRHCEHKVDFCAQSPCQNGGNCNIRQSGHHCICNN 1365
Score = 39.7 bits (91), Expect = 0.013
Identities = 35/128 (27%), Positives = 48/128 (37%), Gaps = 8/128 (6%)
Frame = +3
Query: 363 NEYSCDGFGNK---ICREGLYYNAQESKCLKNNCISSNIQCQNNGYCINNGLTYECKCLD 533
N +C +GN C +G S C K + CQN G C + YEC+C
Sbjct: 1156 NNGTCKDYGNSHVCYCSQGY----AGSYCQKEIDECQSQPCQNGGTCRDLIGAYECQCRQ 1211
Query: 534 SYIGKLCE-KXXXXXXXXXXXXGKCF--VQNHGDKLYACSCSEGFTGEKCDLR--IYQPC 698
+ G+ CE G C V N ++CSC G G C++ +P
Sbjct: 1212 GFQGQNCELNIDDCAPNPCQNGGTCHDRVMN-----FSCSCPPGTMGIICEINKDDCKPG 1266
Query: 699 ICPKNMKC 722
C N C
Sbjct: 1267 ACHNNGSC 1274
Score = 35.4 bits (80), Expect = 0.24
Identities = 31/120 (25%), Positives = 46/120 (38%), Gaps = 15/120 (12%)
Frame = +3
Query: 366 EYSCDGFGNKICREGLYYNAQES--KCLKNN------CISSNIQCQNN----GYCI--NN 503
E+ D C+ G N ++S C+ NN C S C +N G C+ +
Sbjct: 1335 EHKVDFCAQSPCQNGGNCNIRQSGHHCICNNGFYGKNCELSGQDCDSNPCRVGNCVVADE 1394
Query: 504 GLTYECKCLDSYIGKLCE-KXXXXXXXXXXXXGKCFVQNHGDKLYACSCSEGFTGEKCDL 680
G Y C+C +G+ CE G GD Y C C + G++CD+
Sbjct: 1395 GFGYRCECPRGTLGEHCEIDTLDECSPNPCAQGAACEDLLGD--YECLCPSKWKGKRCDI 1452
>sp|P24014|SLIT_DROME Slit protein precursor [Contains: Slit protein N-product; Slit
protein C-product]
Length = 1504
Score = 59.7 bits (143), Expect = 1e-08
Identities = 38/133 (28%), Positives = 49/133 (36%), Gaps = 9/133 (6%)
Frame = +3
Query: 306 CEPNYYPPKQCTTFCFPIENEYSCDGFGNKICREGLYYNAQESKCLKNNCISSNIQCQNN 485
C P + P C YSCD C+ G + + C N N CQN
Sbjct: 1052 CSPEFNPCANGAK-CMDHFTHYSCD------CQAGFH----GTNCTDNIDDCQNHMCQNG 1100
Query: 486 GYCINNGLTYECKCLDSYIGKLCE---------KXXXXXXXXXXXXGKCFVQNHGDKLYA 638
G C++ Y+C+C D Y GK CE G CF N Y
Sbjct: 1101 GTCVDGINDYQCRCPDDYTGKYCEGHNMISMMYPQTSPCQNHECKHGVCFQPNAQGSDYL 1160
Query: 639 CSCSEGFTGEKCD 677
C C G+TG+ C+
Sbjct: 1161 CRCHPGYTGKWCE 1173
Score = 48.1 bits (113), Expect = 4e-05
Identities = 40/160 (25%), Positives = 64/160 (40%), Gaps = 14/160 (8%)
Frame = +3
Query: 261 SITLENLVKMTVEHECEPNYYPPKQCTTFCFPI-ENEYSCDGFGNKICREGLYYNAQESK 437
S V+ + +C + P Q C + + EY C +C+ G Y+ + +
Sbjct: 917 SFVCRGRVRNDILAKCNACFEQPCQNQAQCVALPQREYQC------LCQPG--YHGKHCE 968
Query: 438 CLKNNCISSNIQCQNNGYC--INNGLTYECKCLDSYIGKLCEKXXXXXXXXXXXXGKCFV 611
+ + C + C+NN C + G + C+C Y G CE G+
Sbjct: 969 FMIDACYGN--PCRNNATCTVLEEG-RFSCQCAPGYTGARCETNIDDCL------GEIKC 1019
Query: 612 QNH-----GDKLYACSCSEGFTGEKCDLRI------YQPC 698
QN+ G + Y C C GF+GE CD +I + PC
Sbjct: 1020 QNNATCIDGVESYKCECQPGFSGEFCDTKIQFCSPEFNPC 1059
Score = 47.4 bits (111), Expect = 6e-05
Identities = 35/133 (26%), Positives = 55/133 (41%), Gaps = 10/133 (7%)
Frame = +3
Query: 306 CEPNYYPPKQCTTF---CF--PIENEYSCDGF--GNKICREGLYYNAQESKCLKNNCISS 464
C+P Y+ K C C+ P N +C G C+ Y + ++C+
Sbjct: 958 CQPGYHG-KHCEFMIDACYGNPCRNNATCTVLEEGRFSCQCAPGYTGARCETNIDDCLGE 1016
Query: 465 NIQCQNNGYCINNGLTYECKCLDSYIGKLCE---KXXXXXXXXXXXXGKCFVQNHGDKLY 635
I+CQNN CI+ +Y+C+C + G+ C+ + KC +H Y
Sbjct: 1017 -IKCQNNATCIDGVESYKCECQPGFSGEFCDTKIQFCSPEFNPCANGAKC--MDHFTH-Y 1072
Query: 636 ACSCSEGFTGEKC 674
+C C GF G C
Sbjct: 1073 SCDCQAGFHGTNC 1085
>sp|P13508|GLP1_CAEEL Glp-1 protein precursor
Length = 1295
Score = 59.3 bits (142), Expect = 2e-08
Identities = 37/144 (25%), Positives = 57/144 (39%), Gaps = 7/144 (4%)
Frame = +3
Query: 348 CFPIENEYSC---DGFGNKICREGLYYNAQESKCLKNNCISSNIQCQNNGYCINNGLTYE 518
C+P + C +G+G C EG+ + AQ +C C+N+ Y
Sbjct: 131 CYPFYGGFQCICNNGYGGSYCEEGIDHCAQN-------------ECAEGSTCVNSVYNYY 177
Query: 519 CKCLDSYIGKLCEKXXXXXXXXXXXXGKCFVQNHGDKLYACSCSEGFTGEKCDLRIYQPC 698
C C G+ CE+ G+C DK + C C G+ GE C+ + C
Sbjct: 178 CDCPIGKSGRYCERTECALMGNICNHGRCIPNRDEDKNFRCVCDSGYEGEFCN-KDKNEC 236
Query: 699 I----CPKNMKCNYSESGALFSCT 758
+ C N C ++ G F+CT
Sbjct: 237 LIEETCVNNSTC-FNLHGD-FTCT 258
Score = 47.4 bits (111), Expect = 6e-05
Identities = 26/93 (27%), Positives = 41/93 (44%), Gaps = 1/93 (1%)
Frame = +3
Query: 405 EGLYYNAQESKCLKNNCISSNIQCQNNGYCINNGLTYECKCLDSYIGKLCEK-XXXXXXX 581
EG + N +++CL C NN C N + C C Y GK CE+
Sbjct: 225 EGEFCNKDKNECLIEET------CVNNSTCFNLHGDFTCTCKPGYAGKYCEEAIDMCKDY 278
Query: 582 XXXXXGKCFVQNHGDKLYACSCSEGFTGEKCDL 680
G C + +++ C C +GFTG++C++
Sbjct: 279 VCQNDGYC--AHDSNQMPICYCEQGFTGQRCEI 309
Score = 40.0 bits (92), Expect = 0.010
Identities = 24/78 (30%), Positives = 34/78 (43%), Gaps = 3/78 (3%)
Frame = +3
Query: 474 CQNNGYCI---NNGLTYECKCLDSYIGKLCEKXXXXXXXXXXXXGKCFVQNHGDKLYACS 644
C NN CI N+G Y C C + G CE+ G C N + C+
Sbjct: 378 CVNNATCIDLKNSG--YSCHCPLGFYGLNCEQHLLCTPTTCANGGTCEGVNG---VIRCN 432
Query: 645 CSEGFTGEKCDLRIYQPC 698
C GF+G+ C+++ Q C
Sbjct: 433 CPNGFSGDYCEIKDRQLC 450
Score = 38.5 bits (88), Expect = 0.028
Identities = 30/102 (29%), Positives = 37/102 (36%), Gaps = 11/102 (10%)
Frame = +3
Query: 450 NCISSNIQCQNNGYCINNGLTYECKCLDSYIGKLCE---KXXXXXXXXXXXXGKCF---- 608
+C SN C N+G CIN C C YIG CE K C
Sbjct: 328 HCSRSNGTCYNDGRCING----FCVCEPDYIGDRCEINRKDFKFPDIQSCKYNPCVNNAT 383
Query: 609 ---VQNHGDKLYACSCSEGFTGEKCDLRIY-QPCICPKNMKC 722
++N G Y+C C GF G C+ + P C C
Sbjct: 384 CIDLKNSG---YSCHCPLGFYGLNCEQHLLCTPTTCANGGTC 422
Score = 33.5 bits (75), Expect = 0.90
Identities = 24/100 (24%), Positives = 38/100 (38%)
Frame = +3
Query: 378 DGFGNKICREGLYYNAQESKCLKNNCISSNIQCQNNGYCINNGLTYECKCLDSYIGKLCE 557
+G+G C+ L+ + C + C NNG C ++C C + Y G CE
Sbjct: 103 EGYGGPDCKTPLFSGV--NPCDSDPC--------NNGLCYPFYGGFQCICNNGYGGSYCE 152
Query: 558 KXXXXXXXXXXXXGKCFVQNHGDKLYACSCSEGFTGEKCD 677
+ G V + + Y C C G +G C+
Sbjct: 153 EGIDHCAQNECAEGSTCVNSVYN--YYCDCPIGKSGRYCE 190
Score = 32.3 bits (72), Expect = 2.0
Identities = 28/121 (23%), Positives = 40/121 (33%), Gaps = 2/121 (1%)
Frame = +3
Query: 321 YPPKQCTTFCFPIENE-YSCDGFGNKICREGLY-YNAQESKCLKNNCISSNIQCQNNGYC 494
Y P C ++N YSC C G Y N ++ + + + C N G C
Sbjct: 375 YNPCVNNATCIDLKNSGYSCH------CPLGFYGLNCEQ------HLLCTPTTCANGGTC 422
Query: 495 INNGLTYECKCLDSYIGKLCEKXXXXXXXXXXXXGKCFVQNHGDKLYACSCSEGFTGEKC 674
C C + + G CE +N G C C G+TG C
Sbjct: 423 EGVNGVIRCNCPNGFSGDYCEIKDRQLCSRHPCKNGGVCKNTG----YCECQYGYTGPTC 478
Query: 675 D 677
+
Sbjct: 479 E 479
Score = 31.6 bits (70), Expect = 3.4
Identities = 21/69 (30%), Positives = 30/69 (43%), Gaps = 3/69 (4%)
Frame = +3
Query: 363 NEYSCDGFGNKI---CREGLYYNAQESKCLKNNCISSNIQCQNNGYCINNGLTYECKCLD 533
N +C+G I C G + E +K+ + S C+N G C N G C+C
Sbjct: 418 NGGTCEGVNGVIRCNCPNGFSGDYCE---IKDRQLCSRHPCKNGGVCKNTGY---CECQY 471
Query: 534 SYIGKLCEK 560
Y G CE+
Sbjct: 472 GYTGPTCEE 480
>sp|P46530|NOTC1_BRARE Neurogenic locus notch homolog protein 1 precursor
Length = 2437
Score = 58.5 bits (140), Expect = 3e-08
Identities = 34/109 (31%), Positives = 46/109 (42%), Gaps = 1/109 (0%)
Frame = +3
Query: 354 PIENEYSCDGF-GNKICREGLYYNAQESKCLKNNCISSNIQCQNNGYCINNGLTYECKCL 530
P N C F + IC ++ Q + N C S C+N G CIN +Y C+C
Sbjct: 147 PCANGGQCSAFESHYICTCPPNFHGQTCRQDVNECAVSPSPCRNGGTCINEVGSYLCRCP 206
Query: 531 DSYIGKLCEKXXXXXXXXXXXXGKCFVQNHGDKLYACSCSEGFTGEKCD 677
Y G C++ G VQ D + CSC GFTG+ C+
Sbjct: 207 PEYTGPHCQRLYQPCLPSPCRSGGTCVQT-SDTTHTCSCLPGFTGQTCE 254
Score = 55.1 bits (131), Expect = 3e-07
Identities = 37/143 (25%), Positives = 53/143 (37%), Gaps = 6/143 (4%)
Frame = +3
Query: 348 CFPIENEYSCDGFGNKICREGLYYNAQESKCLKNNCISSNIQCQNNGYCI---NNGLTYE 518
C + N++ C+ CR G Y + + + N C + C+N G C N Y
Sbjct: 1282 CVQLINDFRCE------CRTG--YTGKRCETVFNGC--KDTPCKNGGTCAVASNTKHGYI 1331
Query: 519 CKCLDSYIGKLCEKXXXXXXXXXXXXGKCFVQNHGDKLYACSCSEGFTGEKCDLRIYQPC 698
CKC Y G CE G V H C C+ GF+G +C R+ PC
Sbjct: 1332 CKCQPGYSGSSCEYDSQSCGSLRCRNGATCVSGHLSP--RCLCAPGFSGHECQTRMDSPC 1389
Query: 699 I---CPKNMKCNYSESGALFSCT 758
+ C C + C+
Sbjct: 1390 LVNPCYNGGTCQPISDAPFYRCS 1412
Score = 53.1 bits (126), Expect = 1e-06
Identities = 36/143 (25%), Positives = 62/143 (43%), Gaps = 13/143 (9%)
Frame = +3
Query: 399 CREGLYYNAQESKCLKNNCISSNIQCQNNGYCINNGLTYECKCLDSYIGKLCEKXXXXXX 578
CR G ++ + N C S+ C N G CI++ ++C C+ Y G++CE
Sbjct: 777 CRAG--FSGPNCQMNINECASN--PCLNQGSCIDDVAGFKCNCMLPYTGEVCENVLAPCS 832
Query: 579 XXXXXXGKCFVQNHGDKLYACSCSEGFTGEKCDLRIYQ----PC----ICPK-----NMK 719
G ++ + ++C+C G+ G+ C++ I + PC +C +
Sbjct: 833 PRPCKNGGVCRESEDFQSFSCNCPAGWQGQTCEVDINECVRNPCTNGGVCENLRGGFQCR 892
Query: 720 CNYSESGALFSCTSENEADSSNP 788
CN +GAL EN+ D P
Sbjct: 893 CNPGFTGAL----CENDIDDCEP 911
Score = 50.4 bits (119), Expect = 7e-06
Identities = 38/144 (26%), Positives = 57/144 (39%), Gaps = 10/144 (6%)
Frame = +3
Query: 354 PIENEYSC-DGFGNKIC-----REGLYYNAQESKCLKNNCISSNIQCQNNGYCINNGLTY 515
P +N+ +C D G C EG++ C C+ NG CI+ ++
Sbjct: 459 PCQNDATCLDQIGGFHCICMPGYEGVFCQINSDDCASQPCL--------NGKCIDKINSF 510
Query: 516 ECKCLDSYIGKLCEKXXXXXXXXXXXXG-KCFVQNHGDKLYACSCSEGFTGEKCDLRIYQ 692
C+C + G LC+ G KC G Y C C+ GF+G C+L I +
Sbjct: 511 HCECPKGFSGSLCQVDVDECASTPCKNGAKC---TDGPNKYTCECTPGFSGIHCELDINE 567
Query: 693 PCICPKNMKCNYS---ESGALFSC 755
P C+Y + A F+C
Sbjct: 568 CASSP----CHYGVCRDGVASFTC 587
Score = 49.3 bits (116), Expect = 2e-05
Identities = 42/134 (31%), Positives = 53/134 (39%), Gaps = 9/134 (6%)
Frame = +3
Query: 303 ECEPNYYPPKQCTTFCFPIENEYSCDGFGNKICREGLYYNAQESKCLKNNCISSNIQCQN 482
EC+PN P Q C YSC+ C G Y+ SK + N C+S CQN
Sbjct: 1146 ECQPN---PCQNGATCTDYLGGYSCE------CVPG-YHGMNCSKEI-NECLSQ--PCQN 1192
Query: 483 NGYCINNGLTYECKCLDSYIGKLCE---------KXXXXXXXXXXXXGKCFVQNHGDKLY 635
G CI+ TY+C C G CE G+C + G Y
Sbjct: 1193 GGTCIDLVNTYKCSCPRGTQGVHCEIDIDDCSPSVDPLTGEPRCFNGGRCVDRVGG---Y 1249
Query: 636 ACSCSEGFTGEKCD 677
C C GF GE+C+
Sbjct: 1250 GCVCPAGFVGERCE 1263
Score = 48.9 bits (115), Expect = 2e-05
Identities = 38/151 (25%), Positives = 57/151 (37%), Gaps = 11/151 (7%)
Frame = +3
Query: 369 YSCDGFGNKICREGLYYNAQESKCLKNNCISSNIQCQNNGYCINNGLTYECKCLDSYIGK 548
++CD CR G Y + + N C+S C+N G C + Y C C G
Sbjct: 585 FTCD------CRPG--YTGRLCETNINECLSQ--PCRNGGTCQDRENAYICTCPKGTTGV 634
Query: 549 LCEKXXXXXXXXXXXXGKCFVQNHGDKLYACSCSEGFTGEKCDLRIYQPCICP------- 707
CE GKC + +G Y C C G++G C++ I + P
Sbjct: 635 NCEINIDDCKRKPCDYGKCIDKING---YECVCEPGYSGSMCNINIDDCALNPCHNGGTC 691
Query: 708 ----KNMKCNYSESGALFSCTSENEADSSNP 788
+ C + +C S++ SSNP
Sbjct: 692 IDGVNSFTCLCPDGFRDATCLSQHNECSSNP 722
Score = 47.0 bits (110), Expect = 8e-05
Identities = 36/142 (25%), Positives = 48/142 (33%), Gaps = 6/142 (4%)
Frame = +3
Query: 348 CFPIENEYSC---DGFGNKICREGLYYNAQESKCLKNNCISSNIQCQNNGYCINNGLTYE 518
C N Y C G+ +C N C N C N G CI+ ++
Sbjct: 653 CIDKINGYECVCEPGYSGSMC------NINIDDCALN-------PCHNGGTCIDGVNSFT 699
Query: 519 CKCLDSYIGKLCEKXXXXXXXXXXXXGKCFVQNHGDKLYACSCSEGFTGEKCDLRIYQPC 698
C C D + C G C Q + Y C C G+ G CD+ I + C
Sbjct: 700 CLCPDGFRDATCLSQHNECSSNPCIHGSCLDQINS---YRCVCEAGWMGRNCDININE-C 755
Query: 699 I---CPKNMKCNYSESGALFSC 755
+ C C SG L +C
Sbjct: 756 LSNPCVNGGTCKDMTSGYLCTC 777
Score = 45.8 bits (107), Expect = 2e-04
Identities = 32/126 (25%), Positives = 51/126 (40%), Gaps = 8/126 (6%)
Frame = +3
Query: 348 CFPIENEYSC---DGFGNKICREGLYYNAQESKCLKNNCISSNIQCQNNGYCINNGLTYE 518
C N ++C DGF + C +Q ++C N CI +G C++ +Y
Sbjct: 691 CIDGVNSFTCLCPDGFRDATCL------SQHNECSSNPCI--------HGSCLDQINSYR 736
Query: 519 CKCLDSYIGKLCE-KXXXXXXXXXXXXGKCFVQNHGDKLYACSCSEGFTGEKCDLRIYQ- 692
C C ++G+ C+ G C G Y C+C GF+G C + I +
Sbjct: 737 CVCEAGWMGRNCDININECLSNPCVNGGTCKDMTSG---YLCTCRAGFSGPNCQMNINEC 793
Query: 693 ---PCI 701
PC+
Sbjct: 794 ASNPCL 799
Score = 45.1 bits (105), Expect = 3e-04
Identities = 26/104 (25%), Positives = 41/104 (39%), Gaps = 7/104 (6%)
Frame = +3
Query: 408 GLYYNAQESKC---LKNNCISSNIQCQNNGYCINNGLTYECKCLDSYIGKLCEKXXXXXX 578
G+Y + C + +S + C++ G C++ G T+ C+C Y G C++
Sbjct: 1089 GIYCDVPSVSCEVAARQQGVSVAVLCRHAGQCVDAGNTHLCRCQAGYTGSYCQEQVDECQ 1148
Query: 579 XXXXXXGKCFVQNHGDKLYACSCSEGFTGEKCDLRI----YQPC 698
G G Y+C C G+ G C I QPC
Sbjct: 1149 PNPCQNGATCTDYLGG--YSCECVPGYHGMNCSKEINECLSQPC 1190
Score = 44.7 bits (104), Expect = 4e-04
Identities = 33/138 (23%), Positives = 47/138 (34%), Gaps = 2/138 (1%)
Frame = +3
Query: 348 CFPIENEYSCDGFGNKICREGLYYNAQESKCLKNNCISSNIQCQNNGYCINNGLTYECKC 527
C N Y+C C G C N + C N G C++ ++ C C
Sbjct: 958 CTDCVNSYTCS------CPAGF----SGINCEINTPDCTESSCFNGGTCVDGISSFSCVC 1007
Query: 528 LDSYIGKLCEKXXXXXXXXXXXXGKCFVQNHGDKLYACSCSEGFTGEKCD--LRIYQPCI 701
L + G C+ G +G Y C+C G+TG C +R
Sbjct: 1008 LPGFTGNYCQHDVNECDSRPCQNGGSCQDGYG--TYKCTCPHGYTGLNCQSLVRWCDSSP 1065
Query: 702 CPKNMKCNYSESGALFSC 755
C C + GA F+C
Sbjct: 1066 CKNGGSC--WQQGASFTC 1081
Score = 42.7 bits (99), Expect = 0.001
Identities = 32/133 (24%), Positives = 52/133 (39%), Gaps = 4/133 (3%)
Frame = +3
Query: 348 CFPIENEYSCD---GFGNKICREGLYYNAQESKCLKNNCISSNIQCQNNGYCINNGLTYE 518
C N+Y+C+ GF G++ ++C + C + G C + ++
Sbjct: 541 CTDGPNKYTCECTPGFS------GIHCELDINECASSPC--------HYGVCRDGVASFT 586
Query: 519 CKCLDSYIGKLCE-KXXXXXXXXXXXXGKCFVQNHGDKLYACSCSEGFTGEKCDLRIYQP 695
C C Y G+LCE G C + Y C+C +G TG C++ I
Sbjct: 587 CDCRPGYTGRLCETNINECLSQPCRNGGTC---QDRENAYICTCPKGTTGVNCEINI-DD 642
Query: 696 CICPKNMKCNYSE 734
C K C+Y +
Sbjct: 643 C---KRKPCDYGK 652
Score = 42.7 bits (99), Expect = 0.001
Identities = 25/79 (31%), Positives = 33/79 (41%), Gaps = 1/79 (1%)
Frame = +3
Query: 447 NNCISSNIQCQNNGYCINNGLTYECKCLDSYIGKLCEK-XXXXXXXXXXXXGKCFVQNHG 623
N C S CQN G C + TY+C C Y G C+ G C+ Q
Sbjct: 1021 NECDSR--PCQNGGSCQDGYGTYKCTCPHGYTGLNCQSLVRWCDSSPCKNGGSCWQQGAS 1078
Query: 624 DKLYACSCSEGFTGEKCDL 680
+ C C+ G+TG CD+
Sbjct: 1079 ---FTCQCASGWTGIYCDV 1094
Score = 42.7 bits (99), Expect = 0.001
Identities = 28/122 (22%), Positives = 44/122 (36%), Gaps = 8/122 (6%)
Frame = +3
Query: 336 CTTFCFPIENEYSCDGFGNKICREGLY-------YNAQESKCLKNNCISSNIQCQNNGYC 494
C+ P+ E C G + R G Y + + + N C+S + C
Sbjct: 1223 CSPSVDPLTGEPRCFNGGRCVDRVGGYGCVCPAGFVGERCEGDVNECLSDPCDPSGSYNC 1282
Query: 495 INNGLTYECKCLDSYIGKLCEK-XXXXXXXXXXXXGKCFVQNHGDKLYACSCSEGFTGEK 671
+ + C+C Y GK CE G C V ++ Y C C G++G
Sbjct: 1283 VQLINDFRCECRTGYTGKRCETVFNGCKDTPCKNGGTCAVASNTKHGYICKCQPGYSGSS 1342
Query: 672 CD 677
C+
Sbjct: 1343 CE 1344
Score = 42.4 bits (98), Expect = 0.002
Identities = 34/131 (25%), Positives = 47/131 (35%), Gaps = 8/131 (6%)
Frame = +3
Query: 354 PIENEYSCDG---FGNKICREGLYYNAQESKCLKNNCISSNIQCQNNGYCINNGLTYECK 524
P + +CD G IC Y + C C++ G C+N +++CK
Sbjct: 379 PCQKGSNCDTNPVSGKAICTCPPGYTGSACNQDIDECSLGANPCEHGGRCLNTKGSFQCK 438
Query: 525 CLDSYIGKLCE-KXXXXXXXXXXXXGKCFVQNHGDKLYACSCSEGFTGEKCDLR----IY 689
CL Y G CE C Q G + C C G+ G C +
Sbjct: 439 CLQGYEGPRCEMDVNECKSNPCQNDATCLDQIGG---FHCICMPGYEGVFCQINSDDCAS 495
Query: 690 QPCICPKNMKC 722
QPC+ N KC
Sbjct: 496 QPCL---NGKC 503
Score = 40.4 bits (93), Expect = 0.007
Identities = 34/127 (26%), Positives = 47/127 (37%), Gaps = 3/127 (2%)
Frame = +3
Query: 303 ECEPNYYPPKQCTTFCFPIENEYSC---DGFGNKICREGLYYNAQESKCLKNNCISSNIQ 473
+CEPN P C N + C GF + C E + + C+S+
Sbjct: 908 DCEPN---PCSNGGVCQDRVNGFVCVCLAGFRGERCAEDI-----------DECVSA--P 951
Query: 474 CQNNGYCINNGLTYECKCLDSYIGKLCEKXXXXXXXXXXXXGKCFVQNHGDKLYACSCSE 653
C+N G C + +Y C C + G CE G V G ++C C
Sbjct: 952 CRNGGNCTDCVNSYTCSCPAGFSGINCEINTPDCTESSCFNGGTCVD--GISSFSCVCLP 1009
Query: 654 GFTGEKC 674
GFTG C
Sbjct: 1010 GFTGNYC 1016
Score = 39.3 bits (90), Expect = 0.016
Identities = 36/147 (24%), Positives = 55/147 (37%), Gaps = 12/147 (8%)
Frame = +3
Query: 303 ECE-PNYYPPKQCTT--FCFPI----ENEYSCD---GFGNKICREGLYYNAQESKCLKNN 452
+C+ PN P C C P E CD GF +++C + N
Sbjct: 55 QCQFPNPCNPSPCRNGGVCRPQMQGNEVGVKCDCVLGFSDRLCLTPV------------N 102
Query: 453 CISSNIQCQNNGYCINNGL-TYECKCLDSYIGKLCEKXXXXXXXXXXXXGKCFV-QNHGD 626
N C+N G C L T+ C+C + GK C+ G+C ++H
Sbjct: 103 HACMNSPCRNGGTCSLLTLDTFTCRCQPGWSGKTCQLADPCASNPCANGGQCSAFESH-- 160
Query: 627 KLYACSCSEGFTGEKCDLRIYQPCICP 707
Y C+C F G+ C + + + P
Sbjct: 161 --YICTCPPNFHGQTCRQDVNECAVSP 185
Score = 39.3 bits (90), Expect = 0.016
Identities = 36/150 (24%), Positives = 48/150 (32%), Gaps = 4/150 (2%)
Frame = +3
Query: 360 ENEYSC-DGFGNKICREGLYYNAQESKCLKNNCISSNIQCQNNGYCINNGLTYECKCLDS 536
EN C DG C ++ Q + C S CQN G C N + C C++
Sbjct: 266 ENGGPCIDGINTYNCHCDKHWTGQYCTEDVDECELSPNACQNGGTCHNTIGGFHCVCVNG 325
Query: 537 YIGKLCEKXXXXXXXXXXXXGKCFVQNHGDKLYACSCSEGFTGEKC---DLRIYQPCICP 707
+ G C + G + C C G TG C D I PC
Sbjct: 326 WTGDDCSENIDDCASAACSHGATCHDRVAS--FFCECPHGRTGLLCHLDDACISNPCQKG 383
Query: 708 KNMKCNYSESGALFSCTSENEADSSNPKSD 797
N N A+ +C + N D
Sbjct: 384 SNCDTNPVSGKAICTCPPGYTGSACNQDID 413
Score = 38.1 bits (87), Expect = 0.037
Identities = 28/108 (25%), Positives = 36/108 (33%), Gaps = 5/108 (4%)
Frame = +3
Query: 378 DGFGNKICR-----EGLYYNAQESKCLKNNCISSNIQCQNNGYCINNGLTYECKCLDSYI 542
D +CR G Y Q +C N CQN C + Y C+C+ Y
Sbjct: 1122 DAGNTHLCRCQAGYTGSYCQEQVDECQPN-------PCQNGATCTDYLGGYSCECVPGYH 1174
Query: 543 GKLCEKXXXXXXXXXXXXGKCFVQNHGDKLYACSCSEGFTGEKCDLRI 686
G C K G + Y CSC G G C++ I
Sbjct: 1175 GMNCSKEINECLSQPCQNGGTCIDLVNT--YKCSCPRGTQGVHCEIDI 1220
Score = 38.1 bits (87), Expect = 0.037
Identities = 34/149 (22%), Positives = 54/149 (36%), Gaps = 11/149 (7%)
Frame = +3
Query: 276 NLVKMTVEHECEPNY-YPPKQCTTFC-----FPIENEYSCDGFGNK----ICREGLYYNA 425
N V++ + CE Y K+C T P +N +C N IC+ Y+
Sbjct: 1281 NCVQLINDFRCECRTGYTGKRCETVFNGCKDTPCKNGGTCAVASNTKHGYICKCQPGYSG 1340
Query: 426 QESKCLKNNCISSNIQCQNNGYCINNGLTYECKCLDSYIGKLCEKXXXXXXXXXXXXGKC 605
+ +C +++C+N C++ L+ C C + G C+
Sbjct: 1341 SSCEYDSQSC--GSLRCRNGATCVSGHLSPRCLCAPGFSGHECQTRMDSPCLVNPCYNGG 1398
Query: 606 FVQNHGDK-LYACSCSEGFTGEKCDLRIY 689
Q D Y CSC F G C + Y
Sbjct: 1399 TCQPISDAPFYRCSCPANFNGLLCHILDY 1427
Score = 35.4 bits (80), Expect = 0.24
Identities = 21/74 (28%), Positives = 29/74 (39%), Gaps = 3/74 (4%)
Frame = +3
Query: 474 CQNNGYCINNGLTYECKCLDSYIGKLCEK---XXXXXXXXXXXXGKCFVQNHGDKLYACS 644
C+N G CI+ TY C C + G+ C + G C G + C
Sbjct: 265 CENGGPCIDGINTYNCHCDKHWTGQYCTEDVDECELSPNACQNGGTCHNTIGG---FHCV 321
Query: 645 CSEGFTGEKCDLRI 686
C G+TG+ C I
Sbjct: 322 CVNGWTGDDCSENI 335
>sp|P21783|NOTCH_XENLA Neurogenic locus notch protein homolog precursor (XOTCH protein)
Length = 2524
Score = 58.2 bits (139), Expect = 3e-08
Identities = 38/156 (24%), Positives = 61/156 (39%), Gaps = 6/156 (3%)
Frame = +3
Query: 348 CFPIENEYSCD---GFGNKICREGLYYNAQESKCLKNNCISSNIQCQNNGYCINNGLTYE 518
C NE+ CD GF +C+ + C S+ C+N C++ +Y
Sbjct: 504 CIDKINEFRCDCPTGFSGNLCQHDF-----------DECTST--PCKNGAKCLDGPNSYT 550
Query: 519 CKCLDSYIGKLCEKXXXXXXXXXXXXGKCFVQNHGDKLYACSCSEGFTGEKCDLRIYQPC 698
C+C + + G+ CE+ G C G + C C G+TG CD I + C
Sbjct: 551 CQCTEGFTGRHCEQDINECIPDPCHYGTC---KDGIATFTCLCRPGYTGRLCDNDINE-C 606
Query: 699 I---CPKNMKCNYSESGALFSCTSENEADSSNPKSD 797
+ C +C E+G + +C + K D
Sbjct: 607 LSKPCLNGGQCTDRENGYICTCPKGTTGVNCETKID 642
Score = 57.0 bits (136), Expect = 8e-08
Identities = 36/125 (28%), Positives = 51/125 (40%), Gaps = 3/125 (2%)
Frame = +3
Query: 348 CFPIENEYSCD---GFGNKICREGLYYNAQESKCLKNNCISSNIQCQNNGYCINNGLTYE 518
C P E +Y C GF C++ + N C S C+N G CIN +Y
Sbjct: 156 CLPFEIQYICKCPPGFHGATCKQDI-----------NEC--SQNPCKNGGQCINEFGSYR 202
Query: 519 CKCLDSYIGKLCEKXXXXXXXXXXXXGKCFVQNHGDKLYACSCSEGFTGEKCDLRIYQPC 698
C C + + G+ C++ G Q D Y C+C GF+G+ C+ I
Sbjct: 203 CTCQNRFTGRNCDEPYVPCNPSPCLNGGTCRQT-DDTSYDCTCLPGFSGQNCEENIDD-- 259
Query: 699 ICPKN 713
CP N
Sbjct: 260 -CPSN 263
Score = 56.2 bits (134), Expect = 1e-07
Identities = 43/144 (29%), Positives = 59/144 (40%), Gaps = 10/144 (6%)
Frame = +3
Query: 354 PIENEYSC-DGFGNKIC-----REGLYYNAQESKCLKNNCISSNIQCQNNGYCINNGLTY 515
P +N+ +C D G C EGLY +C N C+ +NG CI+ +
Sbjct: 459 PCQNDSTCLDQIGEFQCICMPGYEGLYCETNIDECASNPCL-------HNGKCIDKINEF 511
Query: 516 ECKCLDSYIGKLCEKXXXXXXXXXXXXG-KCFVQNHGDKLYACSCSEGFTGEKCDLRIYQ 692
C C + G LC+ G KC G Y C C+EGFTG C+ I +
Sbjct: 512 RCDCPTGFSGNLCQHDFDECTSTPCKNGAKCL---DGPNSYTCQCTEGFTGRHCEQDINE 568
Query: 693 PCICPKNMKCNY---SESGALFSC 755
CI C+Y + A F+C
Sbjct: 569 -CIPD---PCHYGTCKDGIATFTC 588
Score = 54.7 bits (130), Expect = 4e-07
Identities = 44/179 (24%), Positives = 75/179 (41%), Gaps = 1/179 (0%)
Frame = +3
Query: 300 HECEPNYYPPKQCTTFCFPIENEYSC-DGFGNKICREGLYYNAQESKCLKNNCISSNIQC 476
+ECE N P N +C D G IC ++ + N C S+ C
Sbjct: 754 NECESN------------PCMNGGTCKDMTGAYICTCKAGFSGPNCQTNINECSSN--PC 799
Query: 477 QNNGYCINNGLTYECKCLDSYIGKLCEKXXXXXXXXXXXXGKCFVQNHGDKLYACSCSEG 656
N+G CI++ Y+C C+ Y G +CE G ++ + ++C C G
Sbjct: 800 LNHGTCIDDVAGYKCNCMLPYTGAICEAVLAPCAGSPCKNGGRCKESEDFETFSCECPPG 859
Query: 657 FTGEKCDLRIYQPCICPKNMKCNYSESGALFSCTSENEADSSNPKSDYSNRKVKQNWKD 833
+ G+ C++ + + C+ N C +GA +C + N + N K Y+ R + + D
Sbjct: 860 WQGQTCEIDMNE-CV---NRPC---RNGA--TCQNTNGSYKCNCKPGYTGRNCEMDIDD 909
Score = 51.6 bits (122), Expect = 3e-06
Identities = 37/146 (25%), Positives = 53/146 (36%), Gaps = 7/146 (4%)
Frame = +3
Query: 339 TTFCFPIENEYSCDGFGNKICREGLYYNAQESKCLKNNCISSNIQCQNNGYCI---NNGL 509
T C + N+Y C+ CR+G + + + + + C + C+N G C N
Sbjct: 1280 TQNCIQLVNDYRCE------CRQG--FTGRRCESVVDGC--KGMPCRNGGTCAVASNTER 1329
Query: 510 TYECKCLDSYIGKLCE-KXXXXXXXXXXXXGKCFVQNHGDKLYACSCSEGFTGEKCDLRI 686
+ CKC + G CE G C K C CSEG+TG C +
Sbjct: 1330 GFICKCPPGFDGATCEYDSRTCSNLRCQNGGTCISVLTSSK---CVCSEGYTGATCQYPV 1386
Query: 687 YQPCI---CPKNMKCNYSESGALFSC 755
PC C C + F C
Sbjct: 1387 ISPCASHPCYNGGTCQFFAEEPFFQC 1412
Score = 50.1 bits (118), Expect = 9e-06
Identities = 29/107 (27%), Positives = 45/107 (42%), Gaps = 1/107 (0%)
Frame = +3
Query: 447 NNCISSNIQCQNNGYCINNGLTYECKCLDSYIGKLCEKXXXXXXXXXXXXG-KCFVQNHG 623
N C+ N C+N C N +Y+C C Y G+ CE G C + G
Sbjct: 870 NECV--NRPCRNGATCQNTNGSYKCNCKPGYTGRNCEMDIDDCQPNPCHNGGSC---SDG 924
Query: 624 DKLYACSCSEGFTGEKCDLRIYQPCICPKNMKCNYSESGALFSCTSE 764
++ C+C GF G KC+ I + P N ++ ++CT +
Sbjct: 925 INMFFCNCPAGFRGPKCEEDINECASNPCKNGANCTDCVNSYTCTCQ 971
Score = 48.5 bits (114), Expect = 3e-05
Identities = 42/136 (30%), Positives = 52/136 (38%), Gaps = 11/136 (8%)
Frame = +3
Query: 303 ECEPNYYPPKQCTTFCFPIENEYSCD---GFGNKICREGLYYNAQESKCLKNNCISSNIQ 473
EC PN P Q C YSC+ G+ C E + N C+S
Sbjct: 1147 ECSPN---PCQNGATCTDYLGGYSCECVAGYHGVNCSEEI-----------NECLSH--P 1190
Query: 474 CQNNGYCINNGLTYECKCLDSYIGKLCE---KXXXXXXXXXXXXGKCFVQNHGDKL---- 632
CQN G CI+ TY+C C G CE KCF N+G +
Sbjct: 1191 CQNGGTCIDLINTYKCSCPRGTQGVHCEINVDDCTPFYDSFTLEPKCF--NNGKCIDRVG 1248
Query: 633 -YACSCSEGFTGEKCD 677
Y C C GF GE+C+
Sbjct: 1249 GYNCICPPGFVGERCE 1264
Score = 48.1 bits (113), Expect = 4e-05
Identities = 32/127 (25%), Positives = 48/127 (37%), Gaps = 10/127 (7%)
Frame = +3
Query: 348 CFPIENEYSCDGFGNKICREG---LYYNAQESKC---LKNNCISSNIQCQNNGYCINNGL 509
C+ N Y C+ C+ G +Y + C K + C+N+G C++ G
Sbjct: 1073 CWQTNNFYRCE------CKSGWTGVYCDVPSVSCEVAAKQQGVDIVHLCRNSGMCVDTGN 1126
Query: 510 TYECKCLDSYIGKLCEKXXXXXXXXXXXXGKCFVQNHGDKLYACSCSEGFTGEKCDLRIY 689
T+ C+C Y G CE+ G G Y+C C G+ G C I
Sbjct: 1127 THFCRCQAGYTGSYCEEQVDECSPNPCQNGATCTDYLGG--YSCECVAGYHGVNCSEEIN 1184
Query: 690 Q----PC 698
+ PC
Sbjct: 1185 ECLSHPC 1191
Score = 47.8 bits (112), Expect = 5e-05
Identities = 45/171 (26%), Positives = 65/171 (38%), Gaps = 15/171 (8%)
Frame = +3
Query: 333 QCTTF--CFPIENEYSCD-------GFGNKICREGLYYNAQESKCLKNNCISSNIQCQNN 485
QC F C P+ + D GF +K+C + N C+ N C+N
Sbjct: 67 QCMNFGTCEPVLQGNAIDFICHCPVGFTDKVCLTPV----------DNACV--NNPCRNG 114
Query: 486 GYC--INNGLTYECKCLDSYIGKLCEKXXXXXXXXXXXXGKCFVQNHGDKLYACSCSEGF 659
G C +N+ Y+C+C + G C++ GKC + Y C C GF
Sbjct: 115 GTCELLNSVTEYKCRCPPGWTGDSCQQADPCASNPCANGGKCL---PFEIQYICKCPPGF 171
Query: 660 TGEKCDLRIYQ----PCICPKNMKCNYSESGALFSCTSENEADSSNPKSDY 800
G C I + PC KN +E G+ + CT +N N Y
Sbjct: 172 HGATCKQDINECSQNPC---KNGGQCINEFGS-YRCTCQNRFTGRNCDEPY 218
Score = 47.0 bits (110), Expect = 8e-05
Identities = 31/105 (29%), Positives = 42/105 (40%), Gaps = 4/105 (3%)
Frame = +3
Query: 396 ICREGLYYNAQESKCLKNNCISSNIQCQNNGYCINNGLTYECKCLDSYIGKLCEKXXXXX 575
+CR G Y + N C+S C N G C + Y C C G CE
Sbjct: 589 LCRPG--YTGRLCDNDINECLSK--PCLNGGQCTDRENGYICTCPKGTTGVNCETKIDDC 644
Query: 576 XXXXXXXGKCFVQNHGDKLYACSCSEGFTGEKCDLRIYQ----PC 698
GKC + G Y C+C G+TG+ C++ I + PC
Sbjct: 645 ASNLCDNGKCIDKIDG---YECTCEPGYTGKLCNININECDSNPC 686
Score = 46.6 bits (109), Expect = 1e-04
Identities = 37/147 (25%), Positives = 54/147 (36%), Gaps = 8/147 (5%)
Frame = +3
Query: 306 CEPNYYPPKQCTTFCFPIENEYSCDGFGNKICREGLY-------YNAQESKCLKNNCISS 464
CE N CT F E C G I R G Y + + + N C+S+
Sbjct: 1217 CEINV---DDCTPFYDSFTLEPKCFNNGKCIDRVGGYNCICPPGFVGERCEGDVNECLSN 1273
Query: 465 NIQCQNNGYCINNGLTYECKCLDSYIGKLCEK-XXXXXXXXXXXXGKCFVQNHGDKLYAC 641
+ CI Y C+C + G+ CE G C V ++ ++ + C
Sbjct: 1274 PCDSRGTQNCIQLVNDYRCECRQGFTGRRCESVVDGCKGMPCRNGGTCAVASNTERGFIC 1333
Query: 642 SCSEGFTGEKCDLRIYQPCICPKNMKC 722
C GF G C+ Y C N++C
Sbjct: 1334 KCPPGFDGATCE---YDSRTC-SNLRC 1356
Score = 46.2 bits (108), Expect = 1e-04
Identities = 49/191 (25%), Positives = 72/191 (37%), Gaps = 24/191 (12%)
Frame = +3
Query: 306 CEPNYYP--PKQCT---TFCFPIENEYSCD---GFGNKICREGLYYNAQESKCLKNNCIS 461
C+ Y P P C T + Y C GF + C E + ++C S
Sbjct: 214 CDEPYVPCNPSPCLNGGTCRQTDDTSYDCTCLPGFSGQNCEENI-----------DDCPS 262
Query: 462 SNIQCQNNGYCINNGLTYECKCLDSYIGKLCEK---XXXXXXXXXXXXGKCFVQNHGDKL 632
+N C+N G C++ TY C+C + G+ C + G C G
Sbjct: 263 NN--CRNGGTCVDGVNTYNCQCPPDWTGQYCTEDVDECQLMPNACQNGGTCHNTYGG--- 317
Query: 633 YACSCSEGFTGEKCDLRI--------YQPCICPKNM-----KCNYSESGALFSCTSENEA 773
Y C C G+TGE C I + C + +C + +G L C +N A
Sbjct: 318 YNCVCVNGWTGEDCSENIDDCANAACHSGATCHDRVASFYCECPHGRTGLL--CHLDN-A 374
Query: 774 DSSNPKSDYSN 806
SNP ++ SN
Sbjct: 375 CISNPCNEGSN 385
Score = 46.2 bits (108), Expect = 1e-04
Identities = 35/146 (23%), Positives = 55/146 (37%), Gaps = 5/146 (3%)
Frame = +3
Query: 300 HECEPNYYPPKQCTTFCFPIENEYSCD---GFGNKICREGLYYNAQESKCLKNNCISSNI 470
+EC N P + C N Y+C GF G++ + C +++C
Sbjct: 946 NECASN---PCKNGANCTDCVNSYTCTCQPGFS------GIHCESNTPDCTESSCF---- 992
Query: 471 QCQNNGYCINNGLTYECKCLDSYIGKLCEKXXXXXXXXXXXXGKCFVQNHGDKLYACSCS 650
N G CI+ T+ C+C + G C+ G ++G Y C+C
Sbjct: 993 ---NGGTCIDGINTFTCQCPPGFTGSYCQHDINECDSKPCLNGGTCQDSYG--TYKCTCP 1047
Query: 651 EGFTGEKCD--LRIYQPCICPKNMKC 722
+G+TG C +R C KC
Sbjct: 1048 QGYTGLNCQNLVRWCDSSPCKNGGKC 1073
Score = 45.1 bits (105), Expect = 3e-04
Identities = 26/87 (29%), Positives = 36/87 (41%)
Frame = +3
Query: 438 CLKNNCISSNIQCQNNGYCINNGLTYECKCLDSYIGKLCEKXXXXXXXXXXXXGKCFVQN 617
C + + +SN C N G C+ + Y CKC + G C++ G +
Sbjct: 139 CQQADPCASN-PCANGGKCLPFEIQYICKCPPGFHGATCKQDINECSQNPCKNGGQCINE 197
Query: 618 HGDKLYACSCSEGFTGEKCDLRIYQPC 698
G Y C+C FTG CD Y PC
Sbjct: 198 FGS--YRCTCQNRFTGRNCD-EPYVPC 221
Score = 43.9 bits (102), Expect = 7e-04
Identities = 38/140 (27%), Positives = 47/140 (33%), Gaps = 4/140 (2%)
Frame = +3
Query: 348 CFPIENEYSCDGFGNKICREGLYYNAQESKCLKNNCISSNIQCQNNGYCINNGLTYECKC 527
C N Y CD C G S C NN + C N G C + Y C C
Sbjct: 729 CHDGVNGYKCD------CEAGW----SGSNCDINNNECESNPCMNGGTCKDMTGAYICTC 778
Query: 528 LDSYIGKLCE-KXXXXXXXXXXXXGKCFVQNHGDKLYACSCSEGFTGEKCDLRIYQPCI- 701
+ G C+ G C G Y C+C +TG C+ + PC
Sbjct: 779 KAGFSGPNCQTNINECSSNPCLNHGTCIDDVAG---YKCNCMLPYTGAICE-AVLAPCAG 834
Query: 702 --CPKNMKCNYSESGALFSC 755
C +C SE FSC
Sbjct: 835 SPCKNGGRCKESEDFETFSC 854
Score = 43.5 bits (101), Expect = 9e-04
Identities = 44/161 (27%), Positives = 58/161 (36%), Gaps = 14/161 (8%)
Frame = +3
Query: 348 CFPIENEYSCDGFGNKICREGLYYNAQESK---CLKNNCISSNIQCQNNGYCINNGLTYE 518
C EN Y C C +G E+K C N C +NG CI+ YE
Sbjct: 617 CTDRENGYICT------CPKGTTGVNCETKIDDCASNLC--------DNGKCIDKIDGYE 662
Query: 519 CKCLDSYIGKLCE-KXXXXXXXXXXXXGKCFVQNHGDKLYACSCSEGFTGEKCDLRIYQ- 692
C C Y GKLC G C Q +G + C C +G+ C + +
Sbjct: 663 CTCEPGYTGKLCNININECDSNPCRNGGTCKDQING---FTCVCPDGYHDHMCLSEVNEC 719
Query: 693 ---PCI---CPKNM---KCNYSESGALFSCTSENEADSSNP 788
PCI C + KC+ + +C N SNP
Sbjct: 720 NSNPCIHGACHDGVNGYKCDCEAGWSGSNCDINNNECESNP 760
Score = 42.7 bits (99), Expect = 0.001
Identities = 30/99 (30%), Positives = 42/99 (42%), Gaps = 3/99 (3%)
Frame = +3
Query: 471 QCQNNGYCINNGLTYECKCLDSYIGKLCE---KXXXXXXXXXXXXGKCFVQNHGDKLYAC 641
+C NNG CI+ Y C C ++G+ CE C +Q D Y C
Sbjct: 1236 KCFNNGKCIDRVGGYNCICPPGFVGERCEGDVNECLSNPCDSRGTQNC-IQLVND--YRC 1292
Query: 642 SCSEGFTGEKCDLRIYQPCICPKNMKCNYSESGALFSCT 758
C +GFTG +C+ + C K M C + A+ S T
Sbjct: 1293 ECRQGFTGRRCE-SVVDGC---KGMPCRNGGTCAVASNT 1327
Score = 41.6 bits (96), Expect = 0.003
Identities = 34/138 (24%), Positives = 48/138 (34%), Gaps = 5/138 (3%)
Frame = +3
Query: 303 ECEPNYYPPKQCTTFCFPIENEYSC-DGFGNKICREGLYYNAQESKCLKNNCISSNIQCQ 479
+C+PN P N SC DG C + + + N C S+ C+
Sbjct: 909 DCQPN------------PCHNGGSCSDGINMFFCNCPAGFRGPKCEEDINECASN--PCK 954
Query: 480 NNGYCINNGLTYECKCLDSYIGKLCEKXXXXXXXXXXXXGKCFVQNHGDKLYACSCSEGF 659
N C + +Y C C + G CE G + G + C C GF
Sbjct: 955 NGANCTDCVNSYTCTCQPGFSGIHCESNTPDCTESSCFNGGTCID--GINTFTCQCPPGF 1012
Query: 660 TGEKCDLRIYQ----PCI 701
TG C I + PC+
Sbjct: 1013 TGSYCQHDINECDSKPCL 1030
Score = 39.3 bits (90), Expect = 0.016
Identities = 35/147 (23%), Positives = 50/147 (34%), Gaps = 11/147 (7%)
Frame = +3
Query: 354 PIENEYSC-DGFGNKICREGLYYNAQESKCLKNNCISSNIQCQNNGYCINNGLTYECKCL 530
P N +C D +G C Y + L C SS C+N G C Y C+C
Sbjct: 1028 PCLNGGTCQDSYGTYKCTCPQGYTGLNCQNLVRWCDSS--PCKNGGKCWQTNNFYRCECK 1085
Query: 531 DSYIGKLCEKXXXXXXXXXXXXGKCFV---QNHG-----DKLYACSCSEGFTGEKCDLRI 686
+ G C+ G V +N G + C C G+TG C+ ++
Sbjct: 1086 SGWTGVYCDVPSVSCEVAAKQQGVDIVHLCRNSGMCVDTGNTHFCRCQAGYTGSYCEEQV 1145
Query: 687 YQ--PCICPKNMKCNYSESGALFSCTS 761
+ P C C G C +
Sbjct: 1146 DECSPNPCQNGATCTDYLGGYSCECVA 1172
Score = 38.9 bits (89), Expect = 0.021
Identities = 21/86 (24%), Positives = 36/86 (41%), Gaps = 1/86 (1%)
Frame = +3
Query: 438 CLKNNCISSNIQCQNNGYCINNGLTYECKCLDSYIGKLCEKXXXXXXXXXXXXGKCFVQN 617
C ++ SN++CQN G CI+ + +C C + Y G C+ Q
Sbjct: 1344 CEYDSRTCSNLRCQNGGTCISVLTSSKCVCSEGYTGATCQYPVISPCASHPCYNGGTCQF 1403
Query: 618 HGDK-LYACSCSEGFTGEKCDLRIYQ 692
++ + C C + F G C + Y+
Sbjct: 1404 FAEEPFFQCFCPKNFNGLFCHILDYE 1429
Score = 37.0 bits (84), Expect = 0.082
Identities = 22/87 (25%), Positives = 34/87 (39%), Gaps = 4/87 (4%)
Frame = +3
Query: 474 CQNNGYCINNGLTYECKCLDSYIGKLCEKXXXXXXXXXXXXGKCFVQNHGDKLYACSCSE 653
C++ G C N +++C C Y G CE + G+ + C C
Sbjct: 422 CEHGGRCTNTLGSFQCNCPQGYAGPRCEIDVNECLSNPCQNDSTCLDQIGE--FQCICMP 479
Query: 654 GFTGEKCDLRIYQ----PCICPKNMKC 722
G+ G C+ I + PC+ N KC
Sbjct: 480 GYEGLYCETNIDECASNPCL--HNGKC 504
Score = 32.7 bits (73), Expect = 1.5
Identities = 18/80 (22%), Positives = 28/80 (35%)
Frame = +3
Query: 438 CLKNNCISSNIQCQNNGYCINNGLTYECKCLDSYIGKLCEKXXXXXXXXXXXXGKCFVQN 617
C +N +N C + C + ++ C+C G LC C
Sbjct: 331 CSENIDDCANAACHSGATCHDRVASFYCECPHGRTGLLCHLDNACISNPCNEGSNCDTNP 390
Query: 618 HGDKLYACSCSEGFTGEKCD 677
K C+C G+TG C+
Sbjct: 391 VNGKAI-CTCPPGYTGPACN 409
>sp|P18168|SERR_DROME Serrate protein precursor (Beaded protein)
Length = 1404
Score = 58.2 bits (139), Expect = 3e-08
Identities = 42/162 (25%), Positives = 66/162 (40%), Gaps = 27/162 (16%)
Frame = +3
Query: 294 VEHECEPNYYPPKQCTTFCFPIENE---YSCDGFGNKICREGLY-YNAQESKCLKNNCIS 461
V +C YY CTTFC P +++ Y+C G K+C G N +E+ C K C
Sbjct: 233 VRVQCAVTYYNTT-CTTFCRPRDDQFGHYACGSEGQKLCLNGWQGVNCEEAIC-KAGCDP 290
Query: 462 SNIQCQNNGYC-----------------------INNGLTYECKCLDSYIGKLCEKXXXX 572
+ +C G C NG ++C C ++ G LC++
Sbjct: 291 VHGKCDRPGECECRPGWRGPLCNECMVYPGCKHGSCNGSAWKCVCDTNWGGILCDQDLNF 350
Query: 573 XXXXXXXXGKCFVQNHGDKLYACSCSEGFTGEKCDLRIYQPC 698
+N Y C+C+EG +GE+C++ + PC
Sbjct: 351 CGTHEPCKHGGTCENTAPDKYRCTCAEGLSGEQCEI-VEHPC 391
Score = 53.5 bits (127), Expect = 8e-07
Identities = 52/231 (22%), Positives = 82/231 (35%), Gaps = 30/231 (12%)
Frame = +3
Query: 300 HECEPNYYPPKQCTTFCFPIENEYSCD---GFGNKICREGLYYNAQESKCLKNNCISSNI 470
+EC PN P + C + +++C+ G+ K C E C +
Sbjct: 797 NECSPN---PCRNGGICLDGDGDFTCECMSGWTGKRCSERA-----------TGCYAG-- 840
Query: 471 QCQNNGYCI----NNGLTYECKCLDSYIGKLC-EKXXXXXXXXXXXXGKCFVQNHGDKLY 635
QCQN G C+ + L C+C + G C E G C G +
Sbjct: 841 QCQNGGTCMPGAPDKALQPHCRCAPGWTGLFCAEAIDQCRGQPCHNGGTC---ESGAGWF 897
Query: 636 ACSCSEGFTGEKCDLRIYQ-------------------PCICP---KNMKCNYSESGALF 749
C C++GF+G C + + + CICP ++C S
Sbjct: 898 RCVCAQGFSGPDCRINVNECSPQPCQGGATCIDGIGGYSCICPPGRHGLRCEILLSDPKS 957
Query: 750 SCTSENEADSSNPKSDYSNRKVKQNWKDVSLSTTIVAAVGCMTILISIGVS 902
+C ++SN S Y+ QNW D++L+ C + G S
Sbjct: 958 AC-----QNASNTISPYTALNRSQNWLDIALTGRTEDDENCNACVCENGTS 1003
Score = 42.4 bits (98), Expect = 0.002
Identities = 28/113 (24%), Positives = 41/113 (36%), Gaps = 3/113 (2%)
Frame = +3
Query: 348 CFPIENEYSC---DGFGNKICREGLYYNAQESKCLKNNCISSNIQCQNNGYCINNGLTYE 518
C + N+Y C GF + C + + C +S C+N G C++ +
Sbjct: 621 CIDLVNDYRCACASGFKGRDCETDI-----------DECATS--PCRNGGECVDMVGKFN 667
Query: 519 CKCLDSYIGKLCEKXXXXXXXXXXXXGKCFVQNHGDKLYACSCSEGFTGEKCD 677
C C Y G LCE+ G C G Y C C G+ C+
Sbjct: 668 CICPLGYSGSLCEEAKENCTPSPCLEGHCLNTPEG---YYCHCPPDRAGKHCE 717
Score = 40.4 bits (93), Expect = 0.007
Identities = 20/74 (27%), Positives = 30/74 (40%)
Frame = +3
Query: 462 SNIQCQNNGYCINNGLTYECKCLDSYIGKLCEKXXXXXXXXXXXXGKCFVQNHGDKLYAC 641
S + C +G C + + CKC + G CE G + GD + C
Sbjct: 762 SGLPCSGHGSCEMSDVGTFCKCHVGHTGTFCEHNLNECSPNPCRNGGICLDGDGD--FTC 819
Query: 642 SCSEGFTGEKCDLR 683
C G+TG++C R
Sbjct: 820 ECMSGWTGKRCSER 833
Score = 37.4 bits (85), Expect = 0.063
Identities = 25/100 (25%), Positives = 38/100 (38%)
Frame = +3
Query: 378 DGFGNKICREGLYYNAQESKCLKNNCISSNIQCQNNGYCINNGLTYECKCLDSYIGKLCE 557
+G+G C E L ++C+ QC+N CI+ Y C C + G+ CE
Sbjct: 597 EGWGGVTCAENL-----------DDCVG---QCRNGATCIDLVNDYRCACASGFKGRDCE 642
Query: 558 KXXXXXXXXXXXXGKCFVQNHGDKLYACSCSEGFTGEKCD 677
G V G + C C G++G C+
Sbjct: 643 TDIDECATSPCRNGGECVDMVGK--FNCICPLGYSGSLCE 680
Score = 31.6 bits (70), Expect = 3.4
Identities = 26/111 (23%), Positives = 38/111 (34%), Gaps = 13/111 (11%)
Frame = +3
Query: 474 CQNNGYCINNGLTYECKCLDSYIGKLCEKXXXXXXXXXXXXGKCFVQNHGDKLYACSCSE 653
C N C N ++ C C + + G C + C + Y C+C+
Sbjct: 578 CINAKECRNQPGSFACICKEGWGGVTCAENLDDCVGQCRNGATCIDLVND---YRCACAS 634
Query: 654 GFTGEKCDLRIYQ----PC---------ICPKNMKCNYSESGALFSCTSEN 767
GF G C+ I + PC + N C SG+L EN
Sbjct: 635 GFKGRDCETDIDECATSPCRNGGECVDMVGKFNCICPLGYSGSLCEEAKEN 685
Score = 30.4 bits (67), Expect = 7.6
Identities = 24/77 (31%), Positives = 30/77 (38%), Gaps = 1/77 (1%)
Frame = +3
Query: 333 QCTTFCFPIENEYSC-DGFGNKICREGLYYNAQESKCLKNNCISSNIQCQNNGYCINNGL 509
+C T P N C D G C L Y+ + K NC S G+C+N
Sbjct: 647 ECATS--PCRNGGECVDMVGKFNCICPLGYSGSLCEEAKENCTPSPCL---EGHCLNTPE 701
Query: 510 TYECKCLDSYIGKLCEK 560
Y C C GK CE+
Sbjct: 702 GYYCHCPPDRAGKHCEQ 718
>sp|Q63722|JAG1_RAT Jagged-1 precursor (Jagged1)
Length = 1219
Score = 57.4 bits (137), Expect = 6e-08
Identities = 42/175 (24%), Positives = 67/175 (38%), Gaps = 25/175 (14%)
Frame = +3
Query: 306 CEPNYYPPKQCTTFCFPIEN---EYSCDGFGNKICREGLYYNAQESKCLKNNCISSNIQC 476
C+ +YY C FC P ++ Y+CD GNK C EG + C + C
Sbjct: 187 CDDHYYG-FGCNKFCRPRDDFFGHYACDQNGNKTCMEGWMGPECNKAICRQGCSPKHGSC 245
Query: 477 QNNGYCINN----GL------------------TYECKCLDSYIGKLCEKXXXXXXXXXX 590
+ G C GL ++C C ++ G+LC+K
Sbjct: 246 KLPGDCRCQYGWQGLYCDKCIPHPGCVHGTCNEPWQCLCETNWGGQLCDKDLNYCGTHQP 305
Query: 591 XXGKCFVQNHGDKLYACSCSEGFTGEKCDLRIYQPCICPKNMKCNYSESGALFSC 755
+ N G Y CSC EG++G C++ + P + + + E+ + F C
Sbjct: 306 CLNRGTCSNTGPDKYQCSCPEGYSGPNCEIAEHACLSDPCHNRGSCKETSSGFEC 360
Score = 50.1 bits (118), Expect = 9e-06
Identities = 29/97 (29%), Positives = 40/97 (41%), Gaps = 5/97 (5%)
Frame = +3
Query: 423 AQESKCLKNNCISSNIQCQNNGYCINNGLTYECKCLDSYIGKLC-EKXXXXXXXXXXXXG 599
A+ S CL N C N G C+ NG ++ C C + + G +C + G
Sbjct: 743 ARNSSCLPN-------PCHNGGTCVVNGDSFTCVCKEGWEGPICTQNTNDCSPHPCYNSG 795
Query: 600 KCFVQNHGDKLYACSCSEGFTGEKCDLRIYQ----PC 698
C GD Y C C+ GF G C + I + PC
Sbjct: 796 TCV---DGDNWYRCECAPGFAGPDCRININECQSSPC 829
Score = 45.1 bits (105), Expect = 3e-04
Identities = 32/120 (26%), Positives = 47/120 (39%), Gaps = 2/120 (1%)
Frame = +3
Query: 447 NNCISSNIQCQNNGYCINNGLTYECKCLDSYIGKLCEKXXXXXXXXXXXXGKCFVQNHGD 626
N+C+ QCQN+ C + Y C C Y G CE+ G QN +
Sbjct: 452 NDCLG---QCQNDASCRDLVNGYRCICPPGYAGDHCERDIDECASNPCLNGG-HCQNEIN 507
Query: 627 KLYACSCSEGFTGEKCDLRI--YQPCICPKNMKCNYSESGALFSCTSENEADSSNPKSDY 800
+ + C C GF+G C L I +P C +C S C + E + + D+
Sbjct: 508 R-FQCLCPTGFSGNLCQLDIDYCEPNPCQNGAQCYNRASDYFCKCPEDYEGKNCSHLKDH 566
Score = 40.8 bits (94), Expect = 0.006
Identities = 31/120 (25%), Positives = 46/120 (38%), Gaps = 4/120 (3%)
Frame = +3
Query: 354 PIENEYSCDGFGNK---ICREGLYYNAQESKCLKNNCISSNIQCQNNGYCINNGLTYECK 524
P N +C G+ +C+EG + C +N S C N+G C++ Y C+
Sbjct: 752 PCHNGGTCVVNGDSFTCVCKEGW----EGPICTQNTNDCSPHPCYNSGTCVDGDNWYRCE 807
Query: 525 CLDSYIGKLCEKXXXXXXXXXXXXGK-CFVQNHGDKLYACSCSEGFTGEKCDLRIYQPCI 701
C + G C G C + +G Y C C G +G KC + CI
Sbjct: 808 CAPGFAGPDCRININECQSSPCAFGATCVDEING---YQCICPPGHSGAKCHEVSGRSCI 864
Score = 40.4 bits (93), Expect = 0.007
Identities = 29/114 (25%), Positives = 46/114 (40%), Gaps = 5/114 (4%)
Frame = +3
Query: 348 CFPIENEYSCD---GFGNKICREGLYYNAQESKCLKNNCISSNIQCQNNGYCINNGLTYE 518
C + N++ CD G+ K C ++++S+C C N G C + T++
Sbjct: 682 CRDLVNDFYCDCKNGWKGKTC------HSRDSQC-------DEATCNNGGTCYDEVDTFK 728
Query: 519 CKCLDSYIGKLCE--KXXXXXXXXXXXXGKCFVQNHGDKLYACSCSEGFTGEKC 674
C C + G C + G C V +GD + C C EG+ G C
Sbjct: 729 CMCPGGWEGTTCNIARNSSCLPNPCHNGGTCVV--NGDS-FTCVCKEGWEGPIC 779
Score = 40.0 bits (92), Expect = 0.010
Identities = 36/168 (21%), Positives = 52/168 (30%), Gaps = 32/168 (19%)
Frame = +3
Query: 348 CFPIENEYSC---DGFGNKICREGLYYNAQESKCLKNNCISSNIQCQNNGYCINNGLTYE 518
C + N Y C G+ C + +C N C+ N G+C N ++
Sbjct: 464 CRDLVNGYRCICPPGYAGDHCERDI------DECASNPCL-------NGGHCQNEINRFQ 510
Query: 519 CKCLDSYIGKLCEKXXXXXXXXXXXXGKCFVQNHGDKLYACSCSEGFTGEKCD------- 677
C C + G LC+ G D Y C C E + G+ C
Sbjct: 511 CLCPTGFSGNLCQLDIDYCEPNPCQNGAQCYNRASD--YFCKCPEDYEGKNCSHLKDHCR 568
Query: 678 ----------------------LRIYQPCICPKNMKCNYSESGALFSC 755
+R +C + KC SESG F+C
Sbjct: 569 TTPCEVIDSCTVAMASNDTPEGVRYISSNVCGPHGKCK-SESGGKFTC 615
Score = 40.0 bits (92), Expect = 0.010
Identities = 28/109 (25%), Positives = 41/109 (37%), Gaps = 3/109 (2%)
Frame = +3
Query: 366 EYSCD---GFGNKICREGLYYNAQESKCLKNNCISSNIQCQNNGYCINNGLTYECKCLDS 536
+++CD GF C E + N+C + C N G CI+ +Y+C C D
Sbjct: 612 KFTCDCNKGFTGTYCHENI-----------NDCEGN--PCTNGGTCIDGVNSYKCICSDG 658
Query: 537 YIGKLCEKXXXXXXXXXXXXGKCFVQNHGDKLYACSCSEGFTGEKCDLR 683
+ G CE G D + C C G+ G+ C R
Sbjct: 659 WEGAHCENNINDCSQNPCHYGGTCRDLVND--FYCDCKNGWKGKTCHSR 705
Score = 39.3 bits (90), Expect = 0.016
Identities = 43/178 (24%), Positives = 67/178 (37%), Gaps = 27/178 (15%)
Frame = +3
Query: 276 NLVKMTVEHECEPNYYPPKQCTTFCFPIENEYSCDGFGNKICREGLYYNAQESKCLKNNC 455
NL ++ +++ CEPN P Q C+ ++Y C C E Y + LK++C
Sbjct: 520 NLCQLDIDY-CEPN---PCQNGAQCYNRASDYFCK------CPED--YEGKNCSHLKDHC 567
Query: 456 --------------------------ISSNIQCQNNGYCIN-NGLTYECKCLDSYIGKLC 554
ISSN+ C +G C + +G + C C + G C
Sbjct: 568 RTTPCEVIDSCTVAMASNDTPEGVRYISSNV-CGPHGKCKSESGGKFTCDCNKGFTGTYC 626
Query: 555 EKXXXXXXXXXXXXGKCFVQNHGDKLYACSCSEGFTGEKCDLRIYQPCICPKNMKCNY 728
+ G + G Y C CS+G+ G C+ I C +N C+Y
Sbjct: 627 HENINDCEGNPCTNGGTCID--GVNSYKCICSDGWEGAHCENNIND---CSQN-PCHY 678
Score = 37.7 bits (86), Expect = 0.048
Identities = 29/124 (23%), Positives = 47/124 (37%), Gaps = 5/124 (4%)
Frame = +3
Query: 363 NEYSCDGFGNKICREGLYYNAQESKCLKNNCISSNIQCQNNGYCINNGLTYECKCLDSYI 542
++Y C C EG Y+ + ++ C+S C N G C +EC+C +
Sbjct: 318 DKYQCS------CPEG--YSGPNCEIAEHACLSD--PCHNRGSCKETSSGFECECSPGWT 367
Query: 543 GKLCE-KXXXXXXXXXXXXGKCFVQNHGDKLYACSCSEGFTGEKCDLRIYQ----PCICP 707
G C G C +G + C C +TG+ C L + PC+
Sbjct: 368 GPTCSTNIDDCSPNNCSHGGTCQDLVNG---FKCVCPPQWTGKTCQLDANECEAKPCVNA 424
Query: 708 KNMK 719
++ K
Sbjct: 425 RSCK 428
Score = 35.8 bits (81), Expect = 0.18
Identities = 34/144 (23%), Positives = 52/144 (36%), Gaps = 9/144 (6%)
Frame = +3
Query: 297 EHECEPNYYPPKQCTTF--CFPIENEY--SCDGFGNKI-CREGLYYNAQESKCLKNNCIS 461
E EC P + P T C P + +C N C + + + N C +
Sbjct: 359 ECECSPGWTGPTCSTNIDDCSPNNCSHGGTCQDLVNGFKCVCPPQWTGKTCQLDANECEA 418
Query: 462 SNIQCQNNGYCINNGLTYECKCLDSYIGKLCEKXXXXXXXXXXXXGKCFVQNHGDKLYAC 641
C N C N +Y C CL ++G+ C+ C +G Y C
Sbjct: 419 K--PCVNARSCKNLIASYYCDCLPGWMGQNCDININDCLGQCQNDASCRDLVNG---YRC 473
Query: 642 SCSEGFTGEKCDLRIYQ----PCI 701
C G+ G+ C+ I + PC+
Sbjct: 474 ICPPGYAGDHCERDIDECASNPCL 497
Score = 33.5 bits (75), Expect = 0.90
Identities = 31/137 (22%), Positives = 48/137 (35%), Gaps = 3/137 (2%)
Frame = +3
Query: 300 HECEPNYYPPKQCTT--FCFPIENEYSCDGFGNKICREGLYYNAQESKCLKNNCISSNIQ 473
++CE N CT C N Y C IC +G + + C N S
Sbjct: 631 NDCEGN-----PCTNGGTCIDGVNSYKC------ICSDGW----EGAHCENNINDCSQNP 675
Query: 474 CQNNGYCINNGLTYECKCLDSYIGKLCE-KXXXXXXXXXXXXGKCFVQNHGDKLYACSCS 650
C G C + + C C + + GK C + G C+ + + C C
Sbjct: 676 CHYGGTCRDLVNDFYCDCKNGWKGKTCHSRDSQCDEATCNNGGTCYDEVD---TFKCMCP 732
Query: 651 EGFTGEKCDLRIYQPCI 701
G+ G C++ C+
Sbjct: 733 GGWEGTTCNIARNSSCL 749
>sp|Q9QXX0|JAG1_MOUSE Jagged-1 precursor (Jagged1)
Length = 1218
Score = 57.0 bits (136), Expect = 8e-08
Identities = 42/175 (24%), Positives = 67/175 (38%), Gaps = 25/175 (14%)
Frame = +3
Query: 306 CEPNYYPPKQCTTFCFPIEN---EYSCDGFGNKICREGLYYNAQESKCLKNNCISSNIQC 476
C+ +YY C FC P ++ Y+CD GNK C EG + C + C
Sbjct: 187 CDDHYYG-FGCNKFCRPRDDFFGHYACDQNGNKTCMEGWMGPDCNKAICRQGCSPKHGSC 245
Query: 477 QNNGYCINN----GL------------------TYECKCLDSYIGKLCEKXXXXXXXXXX 590
+ G C GL ++C C ++ G+LC+K
Sbjct: 246 KLPGDCRCQYGWQGLYCDKCIPHPGCVHGTCNEPWQCLCETNWGGQLCDKDLNYCGTHQP 305
Query: 591 XXGKCFVQNHGDKLYACSCSEGFTGEKCDLRIYQPCICPKNMKCNYSESGALFSC 755
+ N G Y CSC EG++G C++ + P + + + E+ + F C
Sbjct: 306 CLNRGTCSNTGPDKYQCSCPEGYSGPNCEIAEHACLSDPCHNRGSCKETSSGFEC 360
Score = 50.1 bits (118), Expect = 9e-06
Identities = 29/97 (29%), Positives = 40/97 (41%), Gaps = 5/97 (5%)
Frame = +3
Query: 423 AQESKCLKNNCISSNIQCQNNGYCINNGLTYECKCLDSYIGKLC-EKXXXXXXXXXXXXG 599
A+ S CL N C N G C+ NG ++ C C + + G +C + G
Sbjct: 743 ARNSSCLPN-------PCHNGGTCVVNGDSFTCVCKEGWEGPICTQNTNDCSPHPCYNSG 795
Query: 600 KCFVQNHGDKLYACSCSEGFTGEKCDLRIYQ----PC 698
C GD Y C C+ GF G C + I + PC
Sbjct: 796 TCV---DGDNWYRCECAPGFAGPDCRININECQSSPC 829
Score = 45.1 bits (105), Expect = 3e-04
Identities = 32/120 (26%), Positives = 47/120 (39%), Gaps = 2/120 (1%)
Frame = +3
Query: 447 NNCISSNIQCQNNGYCINNGLTYECKCLDSYIGKLCEKXXXXXXXXXXXXGKCFVQNHGD 626
N+C+ QCQN+ C + Y C C Y G CE+ G QN +
Sbjct: 452 NDCLG---QCQNDASCRDLVNGYRCICPPGYAGDHCERDIDECASNPCLNGG-HCQNEIN 507
Query: 627 KLYACSCSEGFTGEKCDLRI--YQPCICPKNMKCNYSESGALFSCTSENEADSSNPKSDY 800
+ + C C GF+G C L I +P C +C S C + E + + D+
Sbjct: 508 R-FQCLCPTGFSGNLCQLDIDYCEPNPCQNGAQCYNRASDYFCKCPEDYEGKNCSHLKDH 566
Score = 42.4 bits (98), Expect = 0.002
Identities = 29/109 (26%), Positives = 43/109 (39%), Gaps = 3/109 (2%)
Frame = +3
Query: 366 EYSCD---GFGNKICREGLYYNAQESKCLKNNCISSNIQCQNNGYCINNGLTYECKCLDS 536
+++CD GF C E + N+C S+ C+N G CI+ +Y+C C D
Sbjct: 612 KFTCDCNKGFTGTYCHENI-----------NDCESN--PCKNGGTCIDGVNSYKCICSDG 658
Query: 537 YIGKLCEKXXXXXXXXXXXXGKCFVQNHGDKLYACSCSEGFTGEKCDLR 683
+ G CE G D + C C G+ G+ C R
Sbjct: 659 WEGAHCENNINDCSQNPCHYGGTCRDLVND--FYCDCKNGWKGKTCHSR 705
Score = 41.6 bits (96), Expect = 0.003
Identities = 34/135 (25%), Positives = 43/135 (31%), Gaps = 31/135 (22%)
Frame = +3
Query: 363 NEYSC---DGFGNKICREGLYYNAQESKCLKNNCISSNIQCQNNGYCINNGLTYECKCLD 533
N + C GF +C+ + Y C N CQN C N Y CKC +
Sbjct: 507 NRFQCLCPTGFSGNLCQLDIDY------CEPN-------PCQNGAQCYNRASDYFCKCPE 553
Query: 534 SYIGKLC----------------------------EKXXXXXXXXXXXXGKCFVQNHGDK 629
Y GK C E GKC Q+ G
Sbjct: 554 DYEGKNCSHLKDHCRTTTCEVIDSCTVAMASNDTPEGVRYISSNVCGPHGKCKSQSGGK- 612
Query: 630 LYACSCSEGFTGEKC 674
+ C C++GFTG C
Sbjct: 613 -FTCDCNKGFTGTYC 626
Score = 40.8 bits (94), Expect = 0.006
Identities = 31/120 (25%), Positives = 46/120 (38%), Gaps = 4/120 (3%)
Frame = +3
Query: 354 PIENEYSCDGFGNK---ICREGLYYNAQESKCLKNNCISSNIQCQNNGYCINNGLTYECK 524
P N +C G+ +C+EG + C +N S C N+G C++ Y C+
Sbjct: 752 PCHNGGTCVVNGDSFTCVCKEGW----EGPICTQNTNDCSPHPCYNSGTCVDGDNWYRCE 807
Query: 525 CLDSYIGKLCEKXXXXXXXXXXXXGK-CFVQNHGDKLYACSCSEGFTGEKCDLRIYQPCI 701
C + G C G C + +G Y C C G +G KC + CI
Sbjct: 808 CAPGFAGPDCRININECQSSPCAFGATCVDEING---YQCICPPGHSGAKCHEVSGRSCI 864
Score = 40.4 bits (93), Expect = 0.007
Identities = 29/114 (25%), Positives = 46/114 (40%), Gaps = 5/114 (4%)
Frame = +3
Query: 348 CFPIENEYSCD---GFGNKICREGLYYNAQESKCLKNNCISSNIQCQNNGYCINNGLTYE 518
C + N++ CD G+ K C ++++S+C C N G C + T++
Sbjct: 682 CRDLVNDFYCDCKNGWKGKTC------HSRDSQC-------DEATCNNGGTCYDEVDTFK 728
Query: 519 CKCLDSYIGKLCE--KXXXXXXXXXXXXGKCFVQNHGDKLYACSCSEGFTGEKC 674
C C + G C + G C V +GD + C C EG+ G C
Sbjct: 729 CMCPGGWEGTTCNIARNSSCLPNPCHNGGTCVV--NGDS-FTCVCKEGWEGPIC 779
Score = 39.3 bits (90), Expect = 0.016
Identities = 26/112 (23%), Positives = 38/112 (33%), Gaps = 3/112 (2%)
Frame = +3
Query: 348 CFPIENEYSC---DGFGNKICREGLYYNAQESKCLKNNCISSNIQCQNNGYCINNGLTYE 518
C + N Y C G+ C + +C N C+ N G+C N ++
Sbjct: 464 CRDLVNGYRCICPPGYAGDHCERDI------DECASNPCL-------NGGHCQNEINRFQ 510
Query: 519 CKCLDSYIGKLCEKXXXXXXXXXXXXGKCFVQNHGDKLYACSCSEGFTGEKC 674
C C + G LC+ G D Y C C E + G+ C
Sbjct: 511 CLCPTGFSGNLCQLDIDYCEPNPCQNGAQCYNRASD--YFCKCPEDYEGKNC 560
Score = 39.3 bits (90), Expect = 0.016
Identities = 43/178 (24%), Positives = 67/178 (37%), Gaps = 27/178 (15%)
Frame = +3
Query: 276 NLVKMTVEHECEPNYYPPKQCTTFCFPIENEYSCDGFGNKICREGLYYNAQESKCLKNNC 455
NL ++ +++ CEPN P Q C+ ++Y C C E Y + LK++C
Sbjct: 520 NLCQLDIDY-CEPN---PCQNGAQCYNRASDYFCK------CPED--YEGKNCSHLKDHC 567
Query: 456 --------------------------ISSNIQCQNNGYCIN-NGLTYECKCLDSYIGKLC 554
ISSN+ C +G C + +G + C C + G C
Sbjct: 568 RTTTCEVIDSCTVAMASNDTPEGVRYISSNV-CGPHGKCKSQSGGKFTCDCNKGFTGTYC 626
Query: 555 EKXXXXXXXXXXXXGKCFVQNHGDKLYACSCSEGFTGEKCDLRIYQPCICPKNMKCNY 728
+ G + G Y C CS+G+ G C+ I C +N C+Y
Sbjct: 627 HENINDCESNPCKNGGTCID--GVNSYKCICSDGWEGAHCENNIND---CSQN-PCHY 678
Score = 37.7 bits (86), Expect = 0.048
Identities = 29/124 (23%), Positives = 47/124 (37%), Gaps = 5/124 (4%)
Frame = +3
Query: 363 NEYSCDGFGNKICREGLYYNAQESKCLKNNCISSNIQCQNNGYCINNGLTYECKCLDSYI 542
++Y C C EG Y+ + ++ C+S C N G C +EC+C +
Sbjct: 318 DKYQCS------CPEG--YSGPNCEIAEHACLSD--PCHNRGSCKETSSGFECECSPGWT 367
Query: 543 GKLCE-KXXXXXXXXXXXXGKCFVQNHGDKLYACSCSEGFTGEKCDLRIYQ----PCICP 707
G C G C +G + C C +TG+ C L + PC+
Sbjct: 368 GPTCSTNIDDCSPNNCSHGGTCQDLVNG---FKCVCPPQWTGKTCQLDANECEAKPCVNA 424
Query: 708 KNMK 719
++ K
Sbjct: 425 RSCK 428
Score = 35.8 bits (81), Expect = 0.18
Identities = 34/144 (23%), Positives = 52/144 (36%), Gaps = 9/144 (6%)
Frame = +3
Query: 297 EHECEPNYYPPKQCTTF--CFPIENEY--SCDGFGNKI-CREGLYYNAQESKCLKNNCIS 461
E EC P + P T C P + +C N C + + + N C +
Sbjct: 359 ECECSPGWTGPTCSTNIDDCSPNNCSHGGTCQDLVNGFKCVCPPQWTGKTCQLDANECEA 418
Query: 462 SNIQCQNNGYCINNGLTYECKCLDSYIGKLCEKXXXXXXXXXXXXGKCFVQNHGDKLYAC 641
C N C N +Y C CL ++G+ C+ C +G Y C
Sbjct: 419 K--PCVNARSCKNLIASYYCDCLPGWMGQNCDININDCLGQCQNDASCRDLVNG---YRC 473
Query: 642 SCSEGFTGEKCDLRIYQ----PCI 701
C G+ G+ C+ I + PC+
Sbjct: 474 ICPPGYAGDHCERDIDECASNPCL 497
Score = 34.7 bits (78), Expect = 0.41
Identities = 32/135 (23%), Positives = 49/135 (36%), Gaps = 1/135 (0%)
Frame = +3
Query: 300 HECEPNYYPPKQCTTFCFPIENEYSCDGFGNKICREGLYYNAQESKCLKNNCISSNIQCQ 479
++CE N P K T C N Y C IC +G + + C N S C
Sbjct: 631 NDCESN--PCKNGGT-CIDGVNSYKC------ICSDGW----EGAHCENNINDCSQNPCH 677
Query: 480 NNGYCINNGLTYECKCLDSYIGKLCE-KXXXXXXXXXXXXGKCFVQNHGDKLYACSCSEG 656
G C + + C C + + GK C + G C+ + + C C G
Sbjct: 678 YGGTCRDLVNDFYCDCKNGWKGKTCHSRDSQCDEATCNNGGTCYDEVD---TFKCMCPGG 734
Query: 657 FTGEKCDLRIYQPCI 701
+ G C++ C+
Sbjct: 735 WEGTTCNIARNSSCL 749
>sp|P14585|LIN12_CAEEL Lin-12 protein precursor
Length = 1429
Score = 55.1 bits (131), Expect = 3e-07
Identities = 39/143 (27%), Positives = 52/143 (36%), Gaps = 3/143 (2%)
Frame = +3
Query: 258 HSITLENLVKMTVEHECEPNYYPPKQCTTFCFPIENEYSC---DGFGNKICREGLYYNAQ 428
H T E L K E C N C +F + C DG+ C+EG
Sbjct: 241 HGSTCELLEK---EDSCASNPCSHGVCISF----SGGFQCICDDGYSGSYCQEG------ 287
Query: 429 ESKCLKNNCISSNIQCQNNGYCINNGLTYECKCLDSYIGKLCEKXXXXXXXXXXXXGKCF 608
K+NC+ N +C+ CIN +Y C C G CEK G C
Sbjct: 288 -----KDNCV--NNKCEAGSKCINGVNSYFCDCPPERTGPYCEKMDCSAIPDICNHGTCI 340
Query: 609 VQNHGDKLYACSCSEGFTGEKCD 677
+K + C C G+ G C+
Sbjct: 341 DSPLSEKAFECQCEPGYEGILCE 363
Score = 49.7 bits (117), Expect = 1e-05
Identities = 26/79 (32%), Positives = 36/79 (45%), Gaps = 1/79 (1%)
Frame = +3
Query: 444 KNNCISSNIQCQNNGYCINNGLTYECKCLDSYIGKLC-EKXXXXXXXXXXXXGKCFVQNH 620
KN C+S N+ C NNG C+N ++ C C + GK C E G C +
Sbjct: 366 KNECLSENM-CLNNGTCVNLPGSFRCDCARGFGGKWCDEPLNMCQDFHCENDGTC--MHT 422
Query: 621 GDKLYACSCSEGFTGEKCD 677
D C C GF G++C+
Sbjct: 423 SDHSPVCQCKNGFIGKRCE 441
Score = 47.8 bits (112), Expect = 5e-05
Identities = 48/185 (25%), Positives = 70/185 (37%), Gaps = 32/185 (17%)
Frame = +3
Query: 279 LVKMTVEHECEPNY------YPPKQCTT--------FCFPIENEYSCD---GFGNKICRE 407
L + E +CEP Y +C + C + + CD GFG K C E
Sbjct: 344 LSEKAFECQCEPGYEGILCEQDKNECLSENMCLNNGTCVNLPGSFRCDCARGFGGKWCDE 403
Query: 408 GLYYNAQESKCLKNNCISSNIQCQNNGYCINNG-LTYECKCLDSYIGKLCEK-------- 560
L N C + C+N+G C++ + C+C + +IGK CEK
Sbjct: 404 PL-----------NMC--QDFHCENDGTCMHTSDHSPVCQCKNGFIGKRCEKECPIGFGG 450
Query: 561 ----XXXXXXXXXXXXGKCFVQNHGDKLYA--CSCSEGFTGEKCDLRIYQPCICPKNMKC 722
GKCF +G K + C C FTG +C++ KN K
Sbjct: 451 VRCDLRLEIGICSRQGGKCF---NGGKCLSGFCVCPPDFTGNQCEVN-------RKNGKS 500
Query: 723 NYSES 737
+ SE+
Sbjct: 501 SLSEN 505
Score = 44.3 bits (103), Expect = 5e-04
Identities = 31/111 (27%), Positives = 43/111 (38%), Gaps = 5/111 (4%)
Frame = +3
Query: 369 YSC---DGFGNKICREGLYYNAQESKCLKNNCISSNIQCQNNGYCINNGLTYECKCLDSY 539
Y+C GF IC + CL+N C N G C + ++ C C +
Sbjct: 527 YACICKQGFEGDICER------HKDLCLEN-------PCSNGGVCHQHRESFSCDCPPGF 573
Query: 540 IGKLC--EKXXXXXXXXXXXXGKCFVQNHGDKLYACSCSEGFTGEKCDLRI 686
G C EK G C N +K C CS GF+G +C+ +I
Sbjct: 574 YGNGCEQEKMFRCLKSTCQNGGVCI--NEEEKGRKCECSYGFSGARCEEKI 622
Score = 40.8 bits (94), Expect = 0.006
Identities = 30/116 (25%), Positives = 45/116 (38%), Gaps = 6/116 (5%)
Frame = +3
Query: 429 ESKCLKNNCISSNIQCQNNGYCINNG--LTYECKCLDSYIGKLCEKXXXXXXXXXXXXGK 602
+S +N C+S C NN CI+ + Y C C + G +CE+ G
Sbjct: 499 KSSLSENLCLSD--PCMNNATCIDVDAHIGYACICKQGFEGDICERHKDLCLENPCSNGG 556
Query: 603 CFVQNHGDKLYACSCSEGFTGEKCDLRIYQPCI---CPKNMKC-NYSESGALFSCT 758
Q+ + ++C C GF G C+ C+ C C N E G C+
Sbjct: 557 VCHQHR--ESFSCDCPPGFYGNGCEQEKMFRCLKSTCQNGGVCINEEEKGRKCECS 610
Score = 38.1 bits (87), Expect = 0.037
Identities = 36/147 (24%), Positives = 54/147 (36%), Gaps = 24/147 (16%)
Frame = +3
Query: 312 PNYYPPKQCTT--FCFP--IENEYSCDGFGNKI---CREGLYYNAQESKCLKNNCISSNI 470
P+ Y C T +C+P N C G GN+ C +G + + + N C +
Sbjct: 104 PSGYGGDDCKTQGWCYPSVCMNGGQCIGAGNRAKCACPDG--FKGERCELDVNECEENKN 161
Query: 471 QCQNNGYCINNGLTYECKCLDSYIGKLCEKXXXXXXXXXXXXGKCFVQ---NH--GDKLY 635
C N C+N TY C C ++ C K CF++ +H G +Y
Sbjct: 162 ACGNRSTCMNTLGTYICVCPQGFLPPDCLKPGNTSTVEFKQP-VCFLEISADHPDGRSMY 220
Query: 636 A------------CSCSEGFTGEKCDL 680
C C G+ G C+L
Sbjct: 221 CQNGGFCDKASSKCQCPPGYHGSTCEL 247
Score = 37.4 bits (85), Expect = 0.063
Identities = 24/100 (24%), Positives = 33/100 (33%)
Frame = +3
Query: 375 CDGFGNKICREGLYYNAQESKCLKNNCISSNIQCQNNGYCINNGLTYECKCLDSYIGKLC 554
CD GN + + C ++ C N G CI G +C C D + G+ C
Sbjct: 91 CDINGNSLLKPSCPSGYGGDDCKTQGWCYPSV-CMNGGQCIGAGNRAKCACPDGFKGERC 149
Query: 555 EKXXXXXXXXXXXXGKCFVQNHGDKLYACSCSEGFTGEKC 674
E G + Y C C +GF C
Sbjct: 150 ELDVNECEENKNACGNRSTCMNTLGTYICVCPQGFLPPDC 189
Score = 37.0 bits (84), Expect = 0.082
Identities = 30/119 (25%), Positives = 44/119 (36%), Gaps = 6/119 (5%)
Frame = +3
Query: 375 CD-GFGNKICREGLYYNAQESKC-LKNNCISSNIQCQNNGYC----INNGLTYECKCLDS 536
CD GFG + C + SKC C+ C IN + C
Sbjct: 51 CDEGFGGEYCEQ----QCDVSKCGADEKCVFDKDYRMETCVCKDCDINGNSLLKPSCPSG 106
Query: 537 YIGKLCEKXXXXXXXXXXXXGKCFVQNHGDKLYACSCSEGFTGEKCDLRIYQPCICPKN 713
Y G C+ G+C + K C+C +GF GE+C+L + + C +N
Sbjct: 107 YGGDDCKTQGWCYPSVCMNGGQCIGAGNRAK---CACPDGFKGERCELDVNE---CEEN 159
Score = 31.2 bits (69), Expect = 4.5
Identities = 26/114 (22%), Positives = 44/114 (38%), Gaps = 20/114 (17%)
Frame = +3
Query: 474 CQNNGYC----INNGLT-YECKCLDSYIGKLCEKXXXXXXXXXXXXGKCFVQN------- 617
C NG+C +N T Y C+C + + G+ CE+ KC
Sbjct: 29 CGRNGHCHAGPVNGTQTSYWCRCDEGFGGEYCEQQCDVSKCGADE--KCVFDKDYRMETC 86
Query: 618 -------HGDKLYACSCSEGFTGEKCDLRIY-QPCICPKNMKCNYSESGALFSC 755
+G+ L SC G+ G+ C + + P +C +C + + A +C
Sbjct: 87 VCKDCDINGNSLLKPSCPSGYGGDDCKTQGWCYPSVCMNGGQCIGAGNRAKCAC 140
Database: Non-redundant SwissProt sequences
Posted date: Dec 6, 2005 7:40 AM
Number of letters in database: 68,354,980
Number of sequences in database: 184,735
Database: swissprot.01
Posted date: Dec 6, 2005 8:18 AM
Number of letters in database: 66,202,850
Number of sequences in database: 184,431
Lambda K H
0.318 0.134 0.401
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 100,242,148
Number of Sequences: 369166
Number of extensions: 2048097
Number of successful extensions: 8994
Number of sequences better than 10.0: 10
Number of HSP's better than 10.0 without gapping: 5778
Number of HSP's successfully gapped in prelim test: 0
Number of HSP's that attempted gapping in prelim test: 0
Number of HSP's gapped (non-prelim): 7730
length of database: 68,354,980
effective HSP length: 111
effective length of database: 47,849,395
effective search space used: 9856975370
frameshift window, decay const: 40, 0.1
T: 12
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)