Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= Dr_sW_006_A21
(623 letters)
Database: Non-redundant SwissProt sequences
184,735 sequences; 68,354,980 total letters
Score E
Sequences producing significant alignments: (bits) Value
sp|P54612|2AAA_PIG Serine/threonine protein phosphatase 2A,... 234 1e-61
sp|P30153|2AAA_HUMAN Serine/threonine protein phosphatase 2... 234 1e-61
sp|P54613|2AAB_PIG Serine/threonine protein phosphatase 2A,... 233 3e-61
sp|P30154|2AAB_HUMAN Serine/threonine protein phosphatase 2... 232 7e-61
sp|P36179|2AAA_DROME Protein phosphatase PP2A, 65 kDa regul... 222 7e-58
sp|Q9UT08|2AAA_SCHPO Protein phosphatase PP2A regulatory su... 203 3e-52
sp|Q09543|2AAA_CAEEL Probable protein phosphatase PP2A regu... 199 6e-51
sp|P36875|2AAA_PEA Protein phosphatase PP2A regulatory subu... 191 2e-48
sp|P31383|2AAA_YEAST Protein phosphatase PP2A regulatory su... 168 9e-42
sp|Q8VI02|PP4R1_RAT Serine/threonine phosphatase 4 regulato... 43 6e-04
>sp|P54612|2AAA_PIG Serine/threonine protein phosphatase 2A, 65 kDa regulatory subunit
A, alpha isoform (PP2A, subunit A, PR65-alpha isoform)
(PP2A, subunit A, R1-alpha isoform)
sp|Q76MZ3|2AAA_MOUSE Serine/threonine protein phosphatase 2A, 65 kDa regulatory subunit
A, alpha isoform (PP2A, subunit A, PR65-alpha isoform)
(PP2A, subunit A, R1-alpha isoform)
Length = 589
Score = 234 bits (598), Expect = 1e-61
Identities = 118/206 (57%), Positives = 154/206 (74%)
Frame = +1
Query: 4 NCHVKSSLATSVMGLAPFIGKQDTITHLLPIFIQQLKDENSEVRGKIISSIEQVHNVLGF 183
N HVKS+LA+ +MGL+P +GK +TI HLLP+F+ QLKDE EVR IIS+++ V+ V+G
Sbjct: 338 NQHVKSALASVIMGLSPILGKDNTIEHLLPLFLAQLKDECPEVRLNIISNLDCVNEVIGI 397
Query: 184 EQLSMNLLPTIVELSADSKWRVRLAIIENFPLLASQLGRKFFDDQLKTGCLSWLVDHVYA 363
QLS +LLP IVEL+ D+KWRVRLAIIE PLLA QLG +FFD++L + C++WLVDHVYA
Sbjct: 398 RQLSQSLLPAIVELAEDAKWRVRLAIIEYMPLLAGQLGVEFFDEKLNSLCMAWLVDHVYA 457
Query: 364 IREAAVKNLTRLTEIFGVEWAESVIVPRMVQLSKDTNYLHRMIGLRCIS*LAPLLGPILT 543
IREAA NL +L E FG EWA + I+P+++ +S D NYLHRM L CI+ L+ + G +T
Sbjct: 458 IREAATSNLKKLVEKFGKEWAHATIIPKVLAMSGDPNYLHRMTTLFCINVLSEVCGQDIT 517
Query: 544 EEKFLPTVLCMRDDEGANVRFKTAQT 621
+ LPTVL M D ANVRF A++
Sbjct: 518 TKHMLPTVLRMAGDPVANVRFNVAKS 543
Score = 62.8 bits (151), Expect = 7e-10
Identities = 49/201 (24%), Positives = 84/201 (41%), Gaps = 4/201 (1%)
Frame = +1
Query: 13 VKSSLATSVMGLAPFIGKQDTITHLLPIFIQQLKDENSEVRGKIISSIEQVHNVLGFEQL 192
V+ + A+ + A + + + ++P+F DE VR + + + +L E L
Sbjct: 181 VRRAAASKLGEFAKVLELDNVKSEIIPMFSNLASDEQDSVRLLAVEACVNIAQLLPQEDL 240
Query: 193 SMNLLPTIVELSADSKWRVRLAIIENFPLLASQLGRKFFDDQLKTGCLSWLVDHVYAIRE 372
++PT+ + + D WRVR + + F L +G + L + + D +R
Sbjct: 241 EALVMPTLRQAAEDKSWRVRYMVADKFTELQKAVGPEITKTDLVPAFQNLMKDCEAEVRA 300
Query: 373 AAVKNLTRLTEIFGVEWAESV----IVPRMVQLSKDTNYLHRMIGLRCIS*LAPLLGPIL 540
AA + E + E+V I+P + +L D N + I L+P+LG
Sbjct: 301 AASHKVKEFCENLSADCRENVIMTQILPCIKELVSDANQHVKSALASVIMGLSPILGKDN 360
Query: 541 TEEKFLPTVLCMRDDEGANVR 603
T E LP L DE VR
Sbjct: 361 TIEHLLPLFLAQLKDECPEVR 381
Score = 38.9 bits (89), Expect = 0.011
Identities = 38/198 (19%), Positives = 77/198 (38%)
Frame = +1
Query: 22 SLATSVMGLAPFIGKQDTITHLLPIFIQQLKDENSEVRGKIISSIEQVHNVLGFEQLSMN 201
+LA + +G + + LLP E + VR K + S+ + + L +
Sbjct: 68 ALAEQLGTFTTLVGGPEYVHCLLPPLESLATVEETVVRDKAVESLRAISHEHSPSDLEAH 127
Query: 202 LLPTIVELSADSKWRVRLAIIENFPLLASQLGRKFFDDQLKTGCLSWLVDHVYAIREAAV 381
+P + L+ + R + F + ++ +L+ + D +R AA
Sbjct: 128 FVPLVKRLAGGDWFTSRTSACGLFSVCYPRVSSAV-KAELRQYFRNLCSDDTPMVRRAAA 186
Query: 382 KNLTRLTEIFGVEWAESVIVPRMVQLSKDTNYLHRMIGLRCIS*LAPLLGPILTEEKFLP 561
L ++ ++ +S I+P L+ D R++ + +A LL E +P
Sbjct: 187 SKLGEFAKVLELDNVKSEIIPMFSNLASDEQDSVRLLAVEACVNIAQLLPQEDLEALVMP 246
Query: 562 TVLCMRDDEGANVRFKTA 615
T+ +D+ VR+ A
Sbjct: 247 TLRQAAEDKSWRVRYMVA 264
>sp|P30153|2AAA_HUMAN Serine/threonine protein phosphatase 2A, 65 kDa regulatory subunit
A, alpha isoform (PP2A, subunit A, PR65-alpha isoform)
(PP2A, subunit A, R1-alpha isoform) (Medium tumor
antigen-associated 61 kDa protein)
Length = 589
Score = 234 bits (598), Expect = 1e-61
Identities = 118/206 (57%), Positives = 154/206 (74%)
Frame = +1
Query: 4 NCHVKSSLATSVMGLAPFIGKQDTITHLLPIFIQQLKDENSEVRGKIISSIEQVHNVLGF 183
N HVKS+LA+ +MGL+P +GK +TI HLLP+F+ QLKDE EVR IIS+++ V+ V+G
Sbjct: 338 NQHVKSALASVIMGLSPILGKDNTIEHLLPLFLAQLKDECPEVRLNIISNLDCVNEVIGI 397
Query: 184 EQLSMNLLPTIVELSADSKWRVRLAIIENFPLLASQLGRKFFDDQLKTGCLSWLVDHVYA 363
QLS +LLP IVEL+ D+KWRVRLAIIE PLLA QLG +FFD++L + C++WLVDHVYA
Sbjct: 398 RQLSQSLLPAIVELAEDAKWRVRLAIIEYMPLLAGQLGVEFFDEKLNSLCMAWLVDHVYA 457
Query: 364 IREAAVKNLTRLTEIFGVEWAESVIVPRMVQLSKDTNYLHRMIGLRCIS*LAPLLGPILT 543
IREAA NL +L E FG EWA + I+P+++ +S D NYLHRM L CI+ L+ + G +T
Sbjct: 458 IREAATSNLKKLVEKFGKEWAHATIIPKVLAMSGDPNYLHRMTTLFCINVLSEVCGQDIT 517
Query: 544 EEKFLPTVLCMRDDEGANVRFKTAQT 621
+ LPTVL M D ANVRF A++
Sbjct: 518 TKHMLPTVLRMAGDPVANVRFNVAKS 543
Score = 60.5 bits (145), Expect = 3e-09
Identities = 48/201 (23%), Positives = 83/201 (41%), Gaps = 4/201 (1%)
Frame = +1
Query: 13 VKSSLATSVMGLAPFIGKQDTITHLLPIFIQQLKDENSEVRGKIISSIEQVHNVLGFEQL 192
V+ + A+ + A + + + ++P+F DE VR + + + +L E L
Sbjct: 181 VRRAAASKLGEFAKVLELDNVKSEIIPMFSNLASDEQDSVRLLAVEACVNIAQLLPQEDL 240
Query: 193 SMNLLPTIVELSADSKWRVRLAIIENFPLLASQLGRKFFDDQLKTGCLSWLVDHVYAIRE 372
++PT+ + + D W VR + + F L +G + L + + D +R
Sbjct: 241 EALVMPTLRQAAEDKSWAVRYMVADKFTELQKAVGPEITKTDLVPAFQNLMKDCEAEVRA 300
Query: 373 AAVKNLTRLTEIFGVEWAESV----IVPRMVQLSKDTNYLHRMIGLRCIS*LAPLLGPIL 540
AA + E + E+V I+P + +L D N + I L+P+LG
Sbjct: 301 AASHKVKEFCENLSADCRENVIMSQILPCIKELVSDANQHVKSALASVIMGLSPILGKDN 360
Query: 541 TEEKFLPTVLCMRDDEGANVR 603
T E LP L DE VR
Sbjct: 361 TIEHLLPLFLAQLKDECPEVR 381
Score = 38.1 bits (87), Expect = 0.018
Identities = 38/198 (19%), Positives = 77/198 (38%)
Frame = +1
Query: 22 SLATSVMGLAPFIGKQDTITHLLPIFIQQLKDENSEVRGKIISSIEQVHNVLGFEQLSMN 201
+LA + +G + + LLP E + VR K + S+ + + L +
Sbjct: 68 ALAEQLGTFTTLVGGPEYVHCLLPPLESLATVEETVVRDKAVESLRAISHEHSPSDLEAH 127
Query: 202 LLPTIVELSADSKWRVRLAIIENFPLLASQLGRKFFDDQLKTGCLSWLVDHVYAIREAAV 381
+P + L+ + R + F + ++ +L+ + D +R AA
Sbjct: 128 FVPLVKRLAGGDWFTSRTSACGLFSVCYPRVSSAV-KAELRQYFRNLCSDDTPMVRRAAA 186
Query: 382 KNLTRLTEIFGVEWAESVIVPRMVQLSKDTNYLHRMIGLRCIS*LAPLLGPILTEEKFLP 561
L ++ ++ +S I+P L+ D R++ + +A LL E +P
Sbjct: 187 SKLGEFAKVLELDNVKSEIIPMFSNLASDEQDSVRLLAVEACVNIAQLLPQEDLEALVMP 246
Query: 562 TVLCMRDDEGANVRFKTA 615
T+ +D+ VR+ A
Sbjct: 247 TLRQAAEDKSWAVRYMVA 264
>sp|P54613|2AAB_PIG Serine/threonine protein phosphatase 2A, 65 kDa regulatory subunit
A, beta isoform (PP2A, subunit A, PR65-beta isoform)
(PP2A, subunit A, R1-beta isoform)
Length = 602
Score = 233 bits (594), Expect = 3e-61
Identities = 116/207 (56%), Positives = 156/207 (75%)
Frame = +1
Query: 1 TNCHVKSSLATSVMGLAPFIGKQDTITHLLPIFIQQLKDENSEVRGKIISSIEQVHNVLG 180
TN HVKS+LA+ +MGL+ +GK++TI HLLP+F+ QLKDE EVR IIS+++ V+ V+G
Sbjct: 350 TNQHVKSALASVIMGLSTILGKENTIEHLLPLFLAQLKDECPEVRLNIISNLDCVNEVIG 409
Query: 181 FEQLSMNLLPTIVELSADSKWRVRLAIIENFPLLASQLGRKFFDDQLKTGCLSWLVDHVY 360
QLS +LLP IVEL+ D+KWRVRLAIIE PLLA QLG +FFD++L + C++WLVDHVY
Sbjct: 410 IRQLSQSLLPAIVELAEDAKWRVRLAIIEYMPLLAGQLGVEFFDEKLNSLCMAWLVDHVY 469
Query: 361 AIREAAVKNLTRLTEIFGVEWAESVIVPRMVQLSKDTNYLHRMIGLRCIS*LAPLLGPIL 540
AIREAA NL +L + FG EWA++ IVP+++ ++ D NYLHRM L CI+ L+ G +
Sbjct: 470 AIREAATNNLMKLVQKFGTEWAQNTIVPKVLVMANDPNYLHRMTTLFCINVLSEACGQEI 529
Query: 541 TEEKFLPTVLCMRDDEGANVRFKTAQT 621
T ++ LP VL M D+ ANVRF A++
Sbjct: 530 TTKQMLPIVLKMAGDQVANVRFNVAKS 556
Score = 65.9 bits (159), Expect = 8e-11
Identities = 51/201 (25%), Positives = 86/201 (42%), Gaps = 4/201 (1%)
Frame = +1
Query: 13 VKSSLATSVMGLAPFIGKQDTITHLLPIFIQQLKDENSEVRGKIISSIEQVHNVLGFEQL 192
V+ + A+ + A + + ++P+F DE VR + + + +L + L
Sbjct: 194 VRRAAASKLGEFAKVLELDSVKSEIVPLFTNLASDEQDSVRLLAVEACVSIAQLLSQDDL 253
Query: 193 SMNLLPTIVELSADSKWRVRLAIIENFPLLASQLGRKFFDDQLKTGCLSWLVDHVYAIRE 372
++PT+ + + D WRVR + + F L +G K + L + L D +R
Sbjct: 254 EALVMPTLRQAAEDKSWRVRYMVADKFSELQRAVGPKITLNDLIPAFQNLLKDCEAEVRA 313
Query: 373 AAVKNLTRLTEIFGVEWAESV----IVPRMVQLSKDTNYLHRMIGLRCIS*LAPLLGPIL 540
AA + L E +E E++ I+P + +L DTN + I L+ +LG
Sbjct: 314 AAAHKVKELCENLPIEGRETIIMNQILPCIKELVSDTNQHVKSALASVIMGLSTILGKEN 373
Query: 541 TEEKFLPTVLCMRDDEGANVR 603
T E LP L DE VR
Sbjct: 374 TIEHLLPLFLAQLKDECPEVR 394
Score = 42.0 bits (97), Expect = 0.001
Identities = 41/198 (20%), Positives = 76/198 (38%)
Frame = +1
Query: 22 SLATSVMGLAPFIGKQDTITHLLPIFIQQLKDENSEVRGKIISSIEQVHNVLGFEQLSMN 201
+LA + +G D LLP E + VR K + S+ Q+ L +
Sbjct: 81 ALAEQLGNFTGLVGGPDFAHCLLPPLESLATVEETVVRDKAVESLRQISQEHTPVALEAH 140
Query: 202 LLPTIVELSADSKWRVRLAIIENFPLLASQLGRKFFDDQLKTGCLSWLVDHVYAIREAAV 381
+P + L++ + R + F + + +++ S D +R AA
Sbjct: 141 FVPLVKRLASGDWFTSRTSACGLFSVCYPRASNAV-KAEIRQHFRSLCSDDTPMVRRAAA 199
Query: 382 KNLTRLTEIFGVEWAESVIVPRMVQLSKDTNYLHRMIGLRCIS*LAPLLGPILTEEKFLP 561
L ++ ++ +S IVP L+ D R++ + +A LL E +P
Sbjct: 200 SKLGEFAKVLELDSVKSEIVPLFTNLASDEQDSVRLLAVEACVSIAQLLSQDDLEALVMP 259
Query: 562 TVLCMRDDEGANVRFKTA 615
T+ +D+ VR+ A
Sbjct: 260 TLRQAAEDKSWRVRYMVA 277
>sp|P30154|2AAB_HUMAN Serine/threonine protein phosphatase 2A, 65 kDa regulatory subunit
A, beta isoform (PP2A, subunit A, PR65-beta isoform)
(PP2A, subunit A, R1-beta isoform)
Length = 601
Score = 232 bits (591), Expect = 7e-61
Identities = 115/207 (55%), Positives = 156/207 (75%)
Frame = +1
Query: 1 TNCHVKSSLATSVMGLAPFIGKQDTITHLLPIFIQQLKDENSEVRGKIISSIEQVHNVLG 180
TN HVKS+LA+ +MGL+ +GK++TI HLLP+F+ QLKDE +VR IIS+++ V+ V+G
Sbjct: 349 TNQHVKSALASVIMGLSTILGKENTIEHLLPLFLAQLKDECPDVRLNIISNLDCVNEVIG 408
Query: 181 FEQLSMNLLPTIVELSADSKWRVRLAIIENFPLLASQLGRKFFDDQLKTGCLSWLVDHVY 360
QLS +LLP IVEL+ D+KWRVRLAIIE PLLA QLG +FFD++L + C++WLVDHVY
Sbjct: 409 IRQLSQSLLPAIVELAEDAKWRVRLAIIEYMPLLAGQLGVEFFDEKLNSLCMAWLVDHVY 468
Query: 361 AIREAAVKNLTRLTEIFGVEWAESVIVPRMVQLSKDTNYLHRMIGLRCIS*LAPLLGPIL 540
AIREAA NL +L + FG EWA++ IVP+++ ++ D NYLHRM L CI+ L+ G +
Sbjct: 469 AIREAATNNLMKLVQKFGTEWAQNTIVPKVLVMANDPNYLHRMTTLFCINALSEACGQEI 528
Query: 541 TEEKFLPTVLCMRDDEGANVRFKTAQT 621
T ++ LP VL M D+ ANVRF A++
Sbjct: 529 TTKQMLPIVLKMAGDQVANVRFNVAKS 555
Score = 66.2 bits (160), Expect = 6e-11
Identities = 51/201 (25%), Positives = 87/201 (43%), Gaps = 4/201 (1%)
Frame = +1
Query: 13 VKSSLATSVMGLAPFIGKQDTITHLLPIFIQQLKDENSEVRGKIISSIEQVHNVLGFEQL 192
V+ + A+ + A + + ++P+F DE VR + + + +L + L
Sbjct: 193 VRRAAASKLGEFAKVLELDSVKSEIVPLFTSLASDEQDSVRLLAVEACVSIAQLLSQDDL 252
Query: 193 SMNLLPTIVELSADSKWRVRLAIIENFPLLASQLGRKFFDDQLKTGCLSWLVDHVYAIRE 372
++PT+ + + D WRVR + + F L +G K + L + L D +R
Sbjct: 253 ETLVMPTLRQAAEDKSWRVRYMVADRFSELQKAMGPKITLNDLIPAFQNLLKDCEAEVRA 312
Query: 373 AAVKNLTRLTEIFGVEWAESV----IVPRMVQLSKDTNYLHRMIGLRCIS*LAPLLGPIL 540
AA + L E +E E++ I+P + +L DTN + I L+ +LG
Sbjct: 313 AAAHKVKELGENLPIEDRETIIMNQILPYIKELVSDTNQHVKSALASVIMGLSTILGKEN 372
Query: 541 TEEKFLPTVLCMRDDEGANVR 603
T E LP L DE +VR
Sbjct: 373 TIEHLLPLFLAQLKDECPDVR 393
Score = 41.6 bits (96), Expect = 0.002
Identities = 44/201 (21%), Positives = 77/201 (38%), Gaps = 3/201 (1%)
Frame = +1
Query: 22 SLATSVMGLAPFIGKQDTITHLLPIFIQQLKDENSEVRGKIISSIEQVHNVLGFEQLSMN 201
+LA + +G D LLP E + VR K + S+ Q+ L
Sbjct: 80 ALAEQLGNFTGLVGGPDFAHCLLPPLENLATVEETVVRDKAVESLRQISQEHTPVALEAY 139
Query: 202 LLPTIVELSADSKWRVRLAIIENFPLL---ASQLGRKFFDDQLKTGCLSWLVDHVYAIRE 372
+P + L++ + R + F + AS + Q ++ C D +R
Sbjct: 140 FVPLVKRLASGDWFTSRTSACGLFSVCYPRASNAVKAETRQQFRSLCS----DDTPMVRR 195
Query: 373 AAVKNLTRLTEIFGVEWAESVIVPRMVQLSKDTNYLHRMIGLRCIS*LAPLLGPILTEEK 552
AA L ++ ++ +S IVP L+ D R++ + +A LL E
Sbjct: 196 AAASKLGEFAKVLELDSVKSEIVPLFTSLASDEQDSVRLLAVEACVSIAQLLSQDDLETL 255
Query: 553 FLPTVLCMRDDEGANVRFKTA 615
+PT+ +D+ VR+ A
Sbjct: 256 VMPTLRQAAEDKSWRVRYMVA 276
>sp|P36179|2AAA_DROME Protein phosphatase PP2A, 65 kDa regulatory subunit (Protein
phosphatase PP2A regulatory subunit A) (PR65)
Length = 591
Score = 222 bits (565), Expect = 7e-58
Identities = 112/206 (54%), Positives = 149/206 (72%)
Frame = +1
Query: 4 NCHVKSSLATSVMGLAPFIGKQDTITHLLPIFIQQLKDENSEVRGKIISSIEQVHNVLGF 183
N HVKS+LA+ +MGL+P +G T+ LLP+F+ QLKDE EVR IIS+++ V++V+G
Sbjct: 340 NPHVKSALASVIMGLSPMLGAYQTVEQLLPLFLIQLKDECPEVRLNIISNLDCVNDVIGI 399
Query: 184 EQLSMNLLPTIVELSADSKWRVRLAIIENFPLLASQLGRKFFDDQLKTGCLSWLVDHVYA 363
+QLS +LLP IVEL+ DSKWRVRLAIIE P LA QLG++FFD +L+ C+ WL DHVYA
Sbjct: 400 QQLSQSLLPAIVELAEDSKWRVRLAIIEYMPALAGQLGQEFFDQKLRGLCMGWLNDHVYA 459
Query: 364 IREAAVKNLTRLTEIFGVEWAESVIVPRMVQLSKDTNYLHRMIGLRCIS*LAPLLGPILT 543
IREAA N+ +L E FG WAE I+P ++ +S++ NYLHRM L C++ LA + G +T
Sbjct: 460 IREAATLNMKKLVEQFGAPWAEQAIIPMILVMSRNKNYLHRMTCLFCLNVLAEVCGTDIT 519
Query: 544 EEKFLPTVLCMRDDEGANVRFKTAQT 621
+ LPTVL + D ANVRF A+T
Sbjct: 520 TKLLLPTVLLLAADPVANVRFNVAKT 545
Score = 58.2 bits (139), Expect = 2e-08
Identities = 51/201 (25%), Positives = 85/201 (42%), Gaps = 4/201 (1%)
Frame = +1
Query: 13 VKSSLATSVMGLAPFIGKQDTITHLLPIFIQQLKDENSEVRGKIISSIEQVHNVLGFEQL 192
V+ + A + A + + + L+P F+Q +D+ VR + + +L + +
Sbjct: 183 VRRAAANKLGEFAKVVETEYLKSDLIPNFVQLAQDDQDSVRLLAVEACVTSAQLLPQDDV 242
Query: 193 SMNLLPTIVELSADSKWRVRLAIIENFPLLASQLGRKFFDDQLKTGCLSWLVDHVYAIRE 372
+LPT+ + ++DS WRVR + E F L +G + L L D +R
Sbjct: 243 EHLVLPTLRQCASDSSWRVRYMVAEKFVDLQKAVGPEITRVDLVPAFQYLLKDAEAEVRA 302
Query: 373 AAVKNL----TRLTEIFGVEWAESVIVPRMVQLSKDTNYLHRMIGLRCIS*LAPLLGPIL 540
A + L ++ V+ S I+P + L D N + I L+P+LG
Sbjct: 303 AVATKVKDFCANLDKVNQVQIILSSILPYVRDLVSDPNPHVKSALASVIMGLSPMLGAYQ 362
Query: 541 TEEKFLPTVLCMRDDEGANVR 603
T E+ LP L DE VR
Sbjct: 363 TVEQLLPLFLIQLKDECPEVR 383
Score = 49.7 bits (117), Expect = 6e-06
Identities = 42/199 (21%), Positives = 81/199 (40%)
Frame = +1
Query: 22 SLATSVMGLAPFIGKQDTITHLLPIFIQQLKDENSEVRGKIISSIEQVHNVLGFEQLSMN 201
+LA + +G + +L+P E + VR K + S+ V + L ++
Sbjct: 70 ALADQLGNFTSLVGGPEFAMYLIPPLESLATVEETVVRDKAVESLRTVAAEHSAQDLEIH 129
Query: 202 LLPTIVELSADSKWRVRLAIIENFPLLASQLGRKFFDDQLKTGCLSWLVDHVYAIREAAV 381
++PT+ L + + R + F + ++ + +L+ D +R AA
Sbjct: 130 VVPTLQRLVSGDWFTSRTSACGLFSVCYPRVTQPV-KAELRANFRKLCQDETPMVRRAAA 188
Query: 382 KNLTRLTEIFGVEWAESVIVPRMVQLSKDTNYLHRMIGLRCIS*LAPLLGPILTEEKFLP 561
L ++ E+ +S ++P VQL++D R++ + A LL E LP
Sbjct: 189 NKLGEFAKVVETEYLKSDLIPNFVQLAQDDQDSVRLLAVEACVTSAQLLPQDDVEHLVLP 248
Query: 562 TVLCMRDDEGANVRFKTAQ 618
T+ D VR+ A+
Sbjct: 249 TLRQCASDSSWRVRYMVAE 267
>sp|Q9UT08|2AAA_SCHPO Protein phosphatase PP2A regulatory subunit A (PR65) (Protein
phosphatase 2A 65 kDa regulatory subunit)
Length = 590
Score = 203 bits (517), Expect = 3e-52
Identities = 101/203 (49%), Positives = 144/203 (70%)
Frame = +1
Query: 10 HVKSSLATSVMGLAPFIGKQDTITHLLPIFIQQLKDENSEVRGKIISSIEQVHNVLGFEQ 189
HV+++L ++ LAP +GK+ T +LLP+F++ LKDEN EVR IIS +E V+ V+G E
Sbjct: 338 HVRAALGMNIGALAPQLGKEKTTEYLLPMFLELLKDENPEVRLNIISKLEVVNKVVGIEL 397
Query: 190 LSMNLLPTIVELSADSKWRVRLAIIENFPLLASQLGRKFFDDQLKTGCLSWLVDHVYAIR 369
LS +LLP IV L+ D +WRVRLAII+ PLLA QLG +FF++++ C+SWL DHVY+IR
Sbjct: 398 LSQSLLPAIVTLAEDKQWRVRLAIIDYIPLLAQQLGVEFFNEKMGNLCMSWLEDHVYSIR 457
Query: 370 EAAVKNLTRLTEIFGVEWAESVIVPRMVQLSKDTNYLHRMIGLRCIS*LAPLLGPILTEE 549
EAA+KNL +LTEIFG+EWA I+P+ + + NYL+RM + IS +AP L + E+
Sbjct: 458 EAAIKNLRKLTEIFGLEWATETIIPKFLAMRSHPNYLYRMTTIFAISEIAPALNAEVIEK 517
Query: 550 KFLPTVLCMRDDEGANVRFKTAQ 618
+ LPT+ + +D N+RF A+
Sbjct: 518 QILPTLEQLVNDPIPNIRFNVAK 540
Score = 60.5 bits (145), Expect = 3e-09
Identities = 53/206 (25%), Positives = 83/206 (40%), Gaps = 7/206 (3%)
Frame = +1
Query: 7 CH-----VKSSLATSVMGLAPFIGKQDTITHLLPIFIQQLKDENSEVRGKIISSIEQVHN 171
CH V+ AT+ + KQ+ I +P+F D+ VR + +
Sbjct: 175 CHDEAPMVRRPAATNCAKFVFLVTKQEAIDEFIPLFNSLSNDDQDSVRLLSFDIMVSLAE 234
Query: 172 VLGFE-QLSMNLLPTIVELSADSKWRVRLAIIENFPLLASQLGRKFFDDQLKTGCLSWLV 348
VL + ++ LL + +DS WR R + NF LA +G D+L + +
Sbjct: 235 VLKSDSEIRHYLLQPLRSFVSDSSWRTRYMVAANFVKLAKVVGPSLIKDELIKPFVLLMK 294
Query: 349 DHVYAIREAAVKNLTRLTEIFGVEWAESVIVPRMVQLSKD-TNYLHRMIGLRCIS*LAPL 525
D +R A + E+ I+P + +L D ++ +G+ I LAP
Sbjct: 295 DTEQEVRRAIATQIPGFCELLDKRIVLEEIIPVIQELINDPAQHVRAALGMN-IGALAPQ 353
Query: 526 LGPILTEEKFLPTVLCMRDDEGANVR 603
LG T E LP L + DE VR
Sbjct: 354 LGKEKTTEYLLPMFLELLKDENPEVR 379
Score = 59.7 bits (143), Expect = 6e-09
Identities = 50/193 (25%), Positives = 84/193 (43%)
Frame = +1
Query: 25 LATSVMGLAPFIGKQDTITHLLPIFIQQLKDENSEVRGKIISSIEQVHNVLGFEQLSMNL 204
+A + + LA +G L+ F+ +KD EVR I + I +L + +
Sbjct: 265 VAANFVKLAKVVGPSLIKDELIKPFVLLMKDTEQEVRRAIATQIPGFCELLDKRIVLEEI 324
Query: 205 LPTIVELSADSKWRVRLAIIENFPLLASQLGRKFFDDQLKTGCLSWLVDHVYAIREAAVK 384
+P I EL D VR A+ N LA QLG++ + L L L D +R +
Sbjct: 325 IPVIQELINDPAQHVRAALGMNIGALAPQLGKEKTTEYLLPMFLELLKDENPEVRLNIIS 384
Query: 385 NLTRLTEIFGVEWAESVIVPRMVQLSKDTNYLHRMIGLRCIS*LAPLLGPILTEEKFLPT 564
L + ++ G+E ++P +V L++D + R+ + I LA LG EK
Sbjct: 385 KLEVVNKVVGIELLSQSLLPAIVTLAEDKQWRVRLAIIDYIPLLAQQLGVEFFNEKMGNL 444
Query: 565 VLCMRDDEGANVR 603
+ +D ++R
Sbjct: 445 CMSWLEDHVYSIR 457
>sp|Q09543|2AAA_CAEEL Probable protein phosphatase PP2A regulatory subunit (Protein
phosphatase PP2A regulatory subunit A)
Length = 590
Score = 199 bits (505), Expect = 6e-51
Identities = 102/203 (50%), Positives = 144/203 (70%)
Frame = +1
Query: 13 VKSSLATSVMGLAPFIGKQDTITHLLPIFIQQLKDENSEVRGKIISSIEQVHNVLGFEQL 192
VKS LA +MGLAP IGK+ T++ LLPI++Q L D+ EVR IISS+++V+ V+G QL
Sbjct: 343 VKSELAGVIMGLAPLIGKEQTVSELLPIYMQLLNDQTPEVRLNIISSLDKVNEVIGAAQL 402
Query: 193 SMNLLPTIVELSADSKWRVRLAIIENFPLLASQLGRKFFDDQLKTGCLSWLVDHVYAIRE 372
S +LLP IV L+ D KWRVRLAI++ PLLASQLG++FFD++L CL+WL DHV++IRE
Sbjct: 403 STSLLPAIVGLAEDGKWRVRLAIVQFMPLLASQLGQEFFDEKLLPLCLNWLTDHVFSIRE 462
Query: 373 AAVKNLTRLTEIFGVEWAESVIVPRMVQLSKDTNYLHRMIGLRCIS*LAPLLGPILTEEK 552
A+ + LT+ FG +WA + IVP+M +L KDTNYL RM L C++ L+ + ++
Sbjct: 463 ASTLIMKELTQKFGGQWASTNIVPKMQKLQKDTNYLQRMTCLFCLNTLSEAMTQEQILKE 522
Query: 553 FLPTVLCMRDDEGANVRFKTAQT 621
+P V + +D+ NVRF A++
Sbjct: 523 IMPIVKDLVEDDVPNVRFNAAKS 545
Score = 43.9 bits (102), Expect = 3e-04
Identities = 41/167 (24%), Positives = 67/167 (40%), Gaps = 4/167 (2%)
Frame = +1
Query: 115 DENSEVRGKIISSIEQVHNVLGFEQLSMNLLPTIVELSADSKWRVRLAIIENFPLLASQL 294
DE VR + S +L + P ++EL D WRVR + E + + L
Sbjct: 217 DEQDSVRLLTVESAIAFGTLLDKANKKKLIEPILIELFDDKSWRVRYMVAEKLIEIQNVL 276
Query: 295 GRKFFDDQLKTGCLSWLVDHVYAIREAAVKNLTRLTEIFGVEWAESVIVPRMVQLSK--- 465
G L + L D +R AA + L + +++I ++ ++K
Sbjct: 277 GEDMDTTHLVNMYTNLLKDPEGEVRCAATQRLQEFALNLPEDKRQNIICNSLLNVAKELV 336
Query: 466 -DTNYLHRMIGLRCIS*LAPLLGPILTEEKFLPTVLCMRDDEGANVR 603
D N L + I LAPL+G T + LP + + +D+ VR
Sbjct: 337 TDGNQLVKSELAGVIMGLAPLIGKEQTVSELLPIYMQLLNDQTPEVR 383
>sp|P36875|2AAA_PEA Protein phosphatase PP2A regulatory subunit A (PR65)
Length = 395
Score = 191 bits (484), Expect = 2e-48
Identities = 103/204 (50%), Positives = 135/204 (66%), Gaps = 1/204 (0%)
Frame = +1
Query: 10 HVKSSLATSVMGLAPFIGKQDTITHLLPIFIQQLKDENSEVRGKIISSIEQVHNVLGFEQ 189
HV+S+LA+ +MG+AP +GK TI LLPIF+ LKDE +VR IIS ++QV+ V+G +
Sbjct: 141 HVRSALASVIMGMAPVLGKDATIEQLLPIFLSLLKDEFPDVRLNIISKLDQVNQVIGIDL 200
Query: 190 LSMNLLPTIVELSADSKWRVRLAIIENFPLLASQLGRKFFDDQLKTGCLSWLVDHVYAIR 369
LS +LLP IVEL+ D WRVRLAIIE PLLASQLG FFDD+L + WL D Y+IR
Sbjct: 201 LSQSLLPAIVELAEDRHWRVRLAIIEYIPLLASQLGVGFFDDKLGALIMQWLKDKEYSIR 260
Query: 370 EAAVKNLTRL-TEIFGVEWAESVIVPRMVQLSKDTNYLHRMIGLRCIS*LAPLLGPILTE 546
AA N+ RL E FG EWA I+P+++ + D +YL+RM L IS LAP+LG +T
Sbjct: 261 NAAANNVKRLAAEEFGPEWAMQHIIPQVLDMINDPHYLYRMTILHAISLLAPVLGSEITS 320
Query: 547 EKFLPTVLCMRDDEGANVRFKTAQ 618
LP V+ D N++F A+
Sbjct: 321 TNLLPLVVNASKDRVPNIKFNVAK 344
Score = 74.7 bits (182), Expect = 2e-13
Identities = 50/197 (25%), Positives = 95/197 (48%)
Frame = +1
Query: 13 VKSSLATSVMGLAPFIGKQDTITHLLPIFIQQLKDENSEVRGKIISSIEQVHNVLGFEQL 192
V+ +A + L +G T T L+P +++ L+D +EVR + + +L E
Sbjct: 64 VRYMVANQLYELCEAVGPDSTKTELVPAYVRLLRDNVAEVRIAAAGKVSKFSRILSPELA 123
Query: 193 SMNLLPTIVELSADSKWRVRLAIIENFPLLASQLGRKFFDDQLKTGCLSWLVDHVYAIRE 372
++LP + ELS DS VR A+ +A LG+ +QL LS L D +R
Sbjct: 124 IQHILPCVKELSTDSSQHVRSALASVIMGMAPVLGKDATIEQLLPIFLSLLKDEFPDVRL 183
Query: 373 AAVKNLTRLTEIFGVEWAESVIVPRMVQLSKDTNYLHRMIGLRCIS*LAPLLGPILTEEK 552
+ L ++ ++ G++ ++P +V+L++D ++ R+ + I LA LG ++K
Sbjct: 184 NIISKLDQVNQVIGIDLLSQSLLPAIVELAEDRHWRVRLAIIEYIPLLASQLGVGFFDDK 243
Query: 553 FLPTVLCMRDDEGANVR 603
++ D+ ++R
Sbjct: 244 LGALIMQWLKDKEYSIR 260
Score = 65.9 bits (159), Expect = 8e-11
Identities = 47/175 (26%), Positives = 78/175 (44%)
Frame = +1
Query: 79 THLLPIFIQQLKDENSEVRGKIISSIEQVHNVLGFEQLSMNLLPTIVELSADSKWRVRLA 258
T ++ +F +D+ R + + +L + ++LP IV S D WRVR
Sbjct: 8 TDIMSVFDDLTQDDQDSFRFLAVEGCAALGKLLEPQDCLAHILPVIVNFSQDKSWRVRYM 67
Query: 259 IIENFPLLASQLGRKFFDDQLKTGCLSWLVDHVYAIREAAVKNLTRLTEIFGVEWAESVI 438
+ L +G +L + L D+V +R AA +++ + I E A I
Sbjct: 68 VANQLYELCEAVGPDSTKTELVPAYVRLLRDNVAEVRIAAAGKVSKFSRILSPELAIQHI 127
Query: 439 VPRMVQLSKDTNYLHRMIGLRCIS*LAPLLGPILTEEKFLPTVLCMRDDEGANVR 603
+P + +LS D++ R I +AP+LG T E+ LP L + DE +VR
Sbjct: 128 LPCVKELSTDSSQHVRSALASVIMGMAPVLGKDATIEQLLPIFLSLLKDEFPDVR 182
Score = 37.4 bits (85), Expect = 0.031
Identities = 19/69 (27%), Positives = 35/69 (50%)
Frame = +1
Query: 46 LAPFIGKQDTITHLLPIFIQQLKDENSEVRGKIISSIEQVHNVLGFEQLSMNLLPTIVEL 225
LAP +G + T T+LLP+ + KD ++ + ++ + ++ + + P +VEL
Sbjct: 310 LAPVLGSEITSTNLLPLVVNASKDRVPNIKFNVAKVLQSLIPIVDESVVESTIRPCLVEL 369
Query: 226 SADSKWRVR 252
S D VR
Sbjct: 370 SEDPDVDVR 378
>sp|P31383|2AAA_YEAST Protein phosphatase PP2A regulatory subunit A (PR65)
Length = 635
Score = 168 bits (426), Expect = 9e-42
Identities = 90/205 (43%), Positives = 130/205 (63%), Gaps = 2/205 (0%)
Frame = +1
Query: 13 VKSSLATSVMGLAPFIGKQDTITHLLPIFIQQLKDENSEVRGKIISSIEQVHNVLGFEQL 192
V+S+LA+ + + + K I + LPI + L+DE +VR II+S++ V++V+G E L
Sbjct: 376 VRSALASKITNIVLLLNKDQVINNFLPILLNMLRDEFPDVRLNIIASLKVVNDVIGIELL 435
Query: 193 SMNLLPTIVELSADSKWRVRLAIIENFPLLASQLGRKFFDDQLKTGCLSWLVDHVYAIRE 372
S +LLP I EL+ D WRVR+AIIE P+LA QLG +FFD QL CLSWL D VY+IRE
Sbjct: 436 SDSLLPAITELAKDVNWRVRMAIIEYIPILAEQLGMQFFDQQLSDLCLSWLWDTVYSIRE 495
Query: 373 AAVKNLTRLTEIFGVEWAESVIVPRMVQ--LSKDTNYLHRMIGLRCIS*LAPLLGPILTE 546
AAV NL RLTEIFG +W I+ R+++ L N++ R L ++ L P++ +
Sbjct: 496 AAVNNLKRLTEIFGSDWCRDEIISRLLKFDLQLLENFVSRFTILSALTTLVPVVSLDVVT 555
Query: 547 EKFLPTVLCMRDDEGANVRFKTAQT 621
E+ LP + + DD N+RF A++
Sbjct: 556 EQLLPFISHLADDGVPNIRFNVAKS 580
Score = 50.1 bits (118), Expect = 5e-06
Identities = 49/180 (27%), Positives = 78/180 (43%), Gaps = 2/180 (1%)
Frame = +1
Query: 70 DTITHLLPIFIQQLKDENSEVRGKIISSIEQVHNVLGFEQLSMNLLPTIVELSADSKWRV 249
D I+++ I +D + + SI + N G E + +LL + V+L D WRV
Sbjct: 237 DYISNIFQKIINDNQDSVKFLAVDCLISILKFFNAKGDESHTQDLLNSAVKLIGDEAWRV 296
Query: 250 RLAIIENFPLLASQL-GRKFFDDQLKTGCLSWLVDHVYAIREAAVKNLTRLTEIFG-VEW 423
R + F LASQ + + D+L L+ D+ +REA K ++ +
Sbjct: 297 RYMAADRFSDLASQFSSNQAYIDELVQPFLNLCEDNEGDVREAVAKQVSGFAKFLNDPSI 356
Query: 424 AESVIVPRMVQLSKDTNYLHRMIGLRCIS*LAPLLGPILTEEKFLPTVLCMRDDEGANVR 603
+ I+P + LS D + R I+ + LL FLP +L M DE +VR
Sbjct: 357 ILNKILPAVQNLSMDESETVRSALASKITNIVLLLNKDQVINNFLPILLNMLRDEFPDVR 416
Score = 36.2 bits (82), Expect = 0.070
Identities = 33/132 (25%), Positives = 56/132 (42%), Gaps = 4/132 (3%)
Frame = +1
Query: 25 LATSVMGLAPFIGKQDTITHLLPIFIQQLKDENSEVRGKIISSIEQVHNVLGFEQLSMNL 204
LA + P+IG T LLP+ E + VR K + S+ V L EQL +
Sbjct: 96 LAEQLGKFVPYIGGPQYATILLPVLEILASAEETLVREKAVDSLNNVAQELSQEQLFSDF 155
Query: 205 LPTIVELSADSKWRVRLAIIENFPLLASQLGRKFFDDQLKTGCLSWLV----DHVYAIRE 372
+P I L+ + +++ F + ++ DD L+ L+ + D ++
Sbjct: 156 VPLIEHLATADWFSSKVSACGLFKSVIVRIK----DDSLRKNILALYLQLAQDDTPMVKR 211
Query: 373 AAVKNLTRLTEI 408
A KNL L ++
Sbjct: 212 AVGKNLPILIDL 223
Score = 29.6 bits (65), Expect = 6.5
Identities = 18/86 (20%), Positives = 41/86 (47%)
Frame = +1
Query: 46 LAPFIGKQDTITHLLPIFIQQLKDENSEVRGKIISSIEQVHNVLGFEQLSMNLLPTIVEL 225
+A +G + T L+P + +D+ EV + + + +G Q + LLP + L
Sbjct: 64 IALALGPERTRNELIPFLTEVAQDDEDEVFAVLAEQLGKFVPYIGGPQYATILLPVLEIL 123
Query: 226 SADSKWRVRLAIIENFPLLASQLGRK 303
++ + VR +++ +A +L ++
Sbjct: 124 ASAEETLVREKAVDSLNNVAQELSQE 149
>sp|Q8VI02|PP4R1_RAT Serine/threonine phosphatase 4 regulatory subunit 1
Length = 951
Score = 43.1 bits (100), Expect = 6e-04
Identities = 33/131 (25%), Positives = 61/131 (46%), Gaps = 1/131 (0%)
Frame = +1
Query: 1 TNCHVKSSLATSVMGLAPFIGKQDTITHLLPIFIQQLKD-ENSEVRGKIISSIEQVHNVL 177
+N VK+ + +AP +GK T +LP F + D VR ++ + +V+
Sbjct: 185 SNDDVKTEAVAIMCKMAPMVGKDITERLILPRFCEMCCDCRMFHVRKVCAANFGDICSVV 244
Query: 178 GFEQLSMNLLPTIVELSADSKWRVRLAIIENFPLLASQLGRKFFDDQLKTGCLSWLVDHV 357
G + LLP +L +D+ W VR A E F ++ ++ +L ++ + D
Sbjct: 245 GQQATEEMLLPRFFQLCSDNVWGVRKACAECFMAVSCATCQEIRRTKLSALFINLISDPS 304
Query: 358 YAIREAAVKNL 390
+R+AA ++L
Sbjct: 305 RWVRQAAFQSL 315
Score = 40.0 bits (92), Expect = 0.005
Identities = 40/152 (26%), Positives = 66/152 (43%), Gaps = 10/152 (6%)
Frame = +1
Query: 13 VKSSLATSVMGLAPFIGKQDTITHLLPIFIQQLKDENSEVRGKIISSIEQVHNVLGFEQL 192
V+ +LA S+ LA +G Q T L+PIF LKD + EVR ++ + +L ++
Sbjct: 680 VRRTLAFSIHELAVILGDQLTAADLVPIFNGFLKDLD-EVRIGVLKHLHDFLKLLHIDKR 738
Query: 193 SMNLLPTIVELSADS--KWRVRLAIIENFPLLASQLGRKFFDDQLKTGCLSWLVDHVYAI 366
L L D+ WR R + E LL + D L+ L+ D V ++
Sbjct: 739 REYLYQLQEFLVTDNSRNWRFRAELAEQLILLLELYSPRDVYDYLRPIALNLCADKVSSV 798
Query: 367 REAAVKNLTRLTE--------IFGVEWAESVI 438
R + K ++ + + FGVE ++
Sbjct: 799 RWISYKLVSEMVKKLHMATPPTFGVELINELV 830
Score = 39.7 bits (91), Expect = 0.006
Identities = 29/135 (21%), Positives = 64/135 (47%), Gaps = 6/135 (4%)
Frame = +1
Query: 82 HLLPIFIQQLKDENSEVR----GKIISSIEQVHNVLGFEQLSMNLLPTIVELSA-DSKWR 246
+LLPI ++ L D+N++VR +++ +EQ ++ + + P +++L+A DS
Sbjct: 131 YLLPIVVRYLADQNNQVRKTSQAALLALLEQ--ELIERLDVETKVCPVLIDLTAPDSNDD 188
Query: 247 VRLAIIENFPLLASQLGRKFFDDQLKTGCLSWLVD-HVYAIREAAVKNLTRLTEIFGVEW 423
V+ + +A +G+ + + D ++ +R+ N + + G +
Sbjct: 189 VKTEAVAIMCKMAPMVGKDITERLILPRFCEMCCDCRMFHVRKVCAANFGDICSVVGQQA 248
Query: 424 AESVIVPRMVQLSKD 468
E +++PR QL D
Sbjct: 249 TEEMLLPRFFQLCSD 263
Database: Non-redundant SwissProt sequences
Posted date: Dec 6, 2005 7:40 AM
Number of letters in database: 68,354,980
Number of sequences in database: 184,735
Database: swissprot.01
Posted date: Dec 6, 2005 8:18 AM
Number of letters in database: 66,202,850
Number of sequences in database: 184,431
Lambda K H
0.318 0.134 0.401
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 70,208,611
Number of Sequences: 369166
Number of extensions: 1344003
Number of successful extensions: 3390
Number of sequences better than 10.0: 10
Number of HSP's better than 10.0 without gapping: 3252
Number of HSP's successfully gapped in prelim test: 0
Number of HSP's that attempted gapping in prelim test: 0
Number of HSP's gapped (non-prelim): 3358
length of database: 68,354,980
effective HSP length: 106
effective length of database: 48,773,070
effective search space used: 4926080070
frameshift window, decay const: 40, 0.1
T: 12
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)