Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= Dr_sW_005_P18
(682 letters)
Database: Non-redundant SwissProt sequences
184,735 sequences; 68,354,980 total letters
Score E
Sequences producing significant alignments: (bits) Value
sp|Q9FZ36|M3K2_ARATH Mitogen-activated protein kinase kinas... 123 4e-28
sp|O22040|M3K1_ARATH Mitogen-activated protein kinase kinas... 121 2e-27
sp|O22042|M3K3_ARATH Mitogen-activated protein kinase kinas... 118 1e-26
sp|Q13153|PAK1_HUMAN Serine/threonine-protein kinase PAK 1 ... 111 2e-24
sp|Q62829|PAK3_RAT Serine/threonine-protein kinase PAK 3 (p... 111 2e-24
sp|Q99759|M3K3_HUMAN Mitogen-activated protein kinase kinas... 111 2e-24
sp|O75914|PAK3_HUMAN Serine/threonine-protein kinase PAK 3 ... 111 2e-24
sp|Q61036|PAK3_MOUSE Serine/threonine-protein kinase PAK 3 ... 111 2e-24
sp|Q9Y2U5|M3K2_HUMAN Mitogen-activated protein kinase kinas... 110 3e-24
sp|Q61084|M3K3_MOUSE Mitogen-activated protein kinase kinas... 110 3e-24
>sp|Q9FZ36|M3K2_ARATH Mitogen-activated protein kinase kinase kinase 2 (Arabidospsis
NPK1-related protein kinase 2)
Length = 651
Score = 123 bits (309), Expect = 4e-28
Identities = 75/198 (37%), Positives = 108/198 (54%), Gaps = 1/198 (0%)
Frame = +3
Query: 9 GFFRSGKASYIKLDYMANGSLRSWLHKNGAQKEPSIIRFSKQILEALDFLHSQNILHRDL 188
G R + I L+++ GS+ S L K GA E + ++ Q+L L++LH+ I+HRD+
Sbjct: 138 GTVREDETLNILLEFVPGGSISSLLEKFGAFPESVVRTYTNQLLLGLEYLHNHAIMHRDI 197
Query: 189 KGPKILLDNNLDIKLCGFMSAKMFPDASSETFRNHVAESNHGTANWTAPEVINGEGYGSS 368
KG IL+DN IKL F ++K + ++ + A+S GT W APEVI G+ S
Sbjct: 198 KGANILVDNQGCIKLADFGASKQVAELATIS----GAKSMKGTPYWMAPEVILQTGHSFS 253
Query: 369 ADIWSFGAVMVELITGKAPLF-FLASFQAIYRLGTQKKIEFAYPLRCSDALKSFVDPCLD 545
ADIWS G ++E++TGKAP AI+ +GT K P S F+ CL
Sbjct: 254 ADIWSVGCTVIEMVTGKAPWSQQYKEIAAIFHIGTTKS-HPPIPDNISSDANDFLLKCLQ 312
Query: 546 PEPLNRPTVKDLMKHEFL 599
EP RPT +L+KH F+
Sbjct: 313 QEPNLRPTASELLKHPFV 330
>sp|O22040|M3K1_ARATH Mitogen-activated protein kinase kinase kinase 1 (Arabidospsis
NPK1-related protein kinase 1)
Length = 666
Score = 121 bits (303), Expect = 2e-27
Identities = 76/198 (38%), Positives = 108/198 (54%), Gaps = 1/198 (0%)
Frame = +3
Query: 9 GFFRSGKASYIKLDYMANGSLRSWLHKNGAQKEPSIIRFSKQILEALDFLHSQNILHRDL 188
G R I L+++ GS+ S L K G E + +++Q+L L++LH+ I+HRD+
Sbjct: 139 GTVREDDTLNILLEFVPGGSISSLLEKFGPFPESVVRTYTRQLLLGLEYLHNHAIMHRDI 198
Query: 189 KGPKILLDNNLDIKLCGFMSAKMFPDASSETFRNHVAESNHGTANWTAPEVINGEGYGSS 368
KG IL+DN IKL F ++K + ++ T A+S GT W APEVI G+ S
Sbjct: 199 KGANILVDNKGCIKLADFGASKQVAELATMT----GAKSMKGTPYWMAPEVILQTGHSFS 254
Query: 369 ADIWSFGAVMVELITGKAPLF-FLASFQAIYRLGTQKKIEFAYPLRCSDALKSFVDPCLD 545
ADIWS G ++E++TGKAP AI+ +GT K SDA K F+ CL
Sbjct: 255 ADIWSVGCTVIEMVTGKAPWSQQYKEVAAIFFIGTTKSHPPIPDTLSSDA-KDFLLKCLQ 313
Query: 546 PEPLNRPTVKDLMKHEFL 599
P RPT +L+KH F+
Sbjct: 314 EVPNLRPTASELLKHPFV 331
>sp|O22042|M3K3_ARATH Mitogen-activated protein kinase kinase kinase 3 (Arabidospsis
NPK1-related protein kinase 3)
Length = 651
Score = 118 bits (296), Expect = 1e-26
Identities = 72/198 (36%), Positives = 109/198 (55%), Gaps = 1/198 (0%)
Frame = +3
Query: 9 GFFRSGKASYIKLDYMANGSLRSWLHKNGAQKEPSIIRFSKQILEALDFLHSQNILHRDL 188
G R + I ++++ GS+ S L K G+ EP II ++KQ+L L++LH+ I+HRD+
Sbjct: 138 GTVRESDSLNILMEFVPGGSISSLLEKFGSFPEPVIIMYTKQLLLGLEYLHNNGIMHRDI 197
Query: 189 KGPKILLDNNLDIKLCGFMSAKMFPDASSETFRNHVAESNHGTANWTAPEVINGEGYGSS 368
KG IL+DN I+L F ++K + ++ + A+S GT W APEVI G+ S
Sbjct: 198 KGANILVDNKGCIRLADFGASKKVVELATV----NGAKSMKGTPYWMAPEVILQTGHSFS 253
Query: 369 ADIWSFGAVMVELITGKAPLF-FLASFQAIYRLGTQKKIEFAYPLRCSDALKSFVDPCLD 545
ADIWS G ++E+ TGK P F A+ +G + K P S K F+ CL
Sbjct: 254 ADIWSVGCTVIEMATGKPPWSEQYQQFAAVLHIG-RTKAHPPIPEDLSPEAKDFLMKCLH 312
Query: 546 PEPLNRPTVKDLMKHEFL 599
EP R + +L++H F+
Sbjct: 313 KEPSLRLSATELLQHPFV 330
>sp|Q13153|PAK1_HUMAN Serine/threonine-protein kinase PAK 1 (p21-activated kinase 1)
(PAK-1) (P65-PAK) (Alpha-PAK)
Length = 545
Score = 111 bits (278), Expect = 2e-24
Identities = 63/196 (32%), Positives = 103/196 (52%), Gaps = 1/196 (0%)
Frame = +3
Query: 24 GKASYIKLDYMANGSLRSWLHKNGAQKEPSIIRFSKQILEALDFLHSQNILHRDLKGPKI 203
G ++ ++Y+A GSL + + E I ++ L+AL+FLHS ++HRD+K I
Sbjct: 337 GDELWVVMEYLAGGSLTDVVTET-CMDEGQIAAVCRECLQALEFLHSNQVIHRDIKSDNI 395
Query: 204 LLDNNLDIKLCGF-MSAKMFPDASSETFRNHVAESNHGTANWTAPEVINGEGYGSSADIW 380
LL + +KL F A++ P+ S + + GT W APEV+ + YG DIW
Sbjct: 396 LLGMDGSVKLTDFGFCAQITPEQSKRS-------TMVGTPYWMAPEVVTRKAYGPKVDIW 448
Query: 381 SFGAVMVELITGKAPLFFLASFQAIYRLGTQKKIEFAYPLRCSDALKSFVDPCLDPEPLN 560
S G + +E+I G+ P +A+Y + T E P + S + F++ CLD +
Sbjct: 449 SLGIMAIEMIEGEPPYLNENPLRALYLIATNGTPELQNPEKLSAIFRDFLNRCLDMDVEK 508
Query: 561 RPTVKDLMKHEFLNSA 608
R + K+L++H+FL A
Sbjct: 509 RGSAKELLQHQFLKIA 524
>sp|Q62829|PAK3_RAT Serine/threonine-protein kinase PAK 3 (p21-activated kinase 3)
(PAK-3) (Beta-PAK) (p65-PAK)
Length = 544
Score = 111 bits (277), Expect = 2e-24
Identities = 63/196 (32%), Positives = 102/196 (52%), Gaps = 1/196 (0%)
Frame = +3
Query: 24 GKASYIKLDYMANGSLRSWLHKNGAQKEPSIIRFSKQILEALDFLHSQNILHRDLKGPKI 203
G ++ ++Y+A GSL + + E I ++ L+ALDFLHS ++HRD+K I
Sbjct: 335 GDELWVVMEYLAGGSLTDVVTET-CMDEGQIAAVCRECLQALDFLHSNQVIHRDIKSDNI 393
Query: 204 LLDNNLDIKLCGF-MSAKMFPDASSETFRNHVAESNHGTANWTAPEVINGEGYGSSADIW 380
LL + +KL F A++ P+ S + + GT W APEV+ + YG DIW
Sbjct: 394 LLGMDGSVKLTDFGFCAQITPEQSKRS-------TMVGTPYWMAPEVVTRKAYGPKVDIW 446
Query: 381 SFGAVMVELITGKAPLFFLASFQAIYRLGTQKKIEFAYPLRCSDALKSFVDPCLDPEPLN 560
S G + +E++ G+ P +A+Y + T E P R S + F++ CL+ +
Sbjct: 447 SLGIMAIEMVEGEPPYLNENPLRALYLIATNGTPELQNPERLSAVFRDFLNRCLEMDVDR 506
Query: 561 RPTVKDLMKHEFLNSA 608
R + K+L++H FL A
Sbjct: 507 RGSAKELLQHPFLKLA 522
>sp|Q99759|M3K3_HUMAN Mitogen-activated protein kinase kinase kinase 3 (MAPK/ERK kinase
kinase 3) (MEK kinase 3) (MEKK 3)
Length = 626
Score = 111 bits (277), Expect = 2e-24
Identities = 69/194 (35%), Positives = 105/194 (54%), Gaps = 1/194 (0%)
Frame = +3
Query: 18 RSGKASYIKLDYMANGSLRSWLHKNGAQKEPSIIRFSKQILEALDFLHSQNILHRDLKGP 197
R+ K I ++YM GS++ L GA E ++++QILE + +LHS I+HRD+KG
Sbjct: 434 RAEKTLTIFMEYMPGGSVKDQLKAYGALTESVTRKYTRQILEGMSYLHSNMIVHRDIKGA 493
Query: 198 KILLDNNLDIKLCGFMSAKMFPD-ASSETFRNHVAESNHGTANWTAPEVINGEGYGSSAD 374
IL D+ ++KL F ++K S T V GT W +PEVI+GEGYG AD
Sbjct: 494 NILRDSAGNVKLGDFGASKRLQTICMSGTGMRSVT----GTPYWMSPEVISGEGYGRKAD 549
Query: 375 IWSFGAVMVELITGKAPLFFLASFQAIYRLGTQKKIEFAYPLRCSDALKSFVDPCLDPEP 554
+WS G +VE++T K P + AI+++ TQ P S+ + F+ + E
Sbjct: 550 VWSLGCTVVEMLTEKPPWAEYEAMAAIFKIATQ-PTNPQLPSHISEHGRDFLRR-IFVEA 607
Query: 555 LNRPTVKDLMKHEF 596
RP+ ++L+ H F
Sbjct: 608 RQRPSAEELLTHHF 621
>sp|O75914|PAK3_HUMAN Serine/threonine-protein kinase PAK 3 (p21-activated kinase 3)
(PAK-3) (Beta-PAK) (Oligophrenin-3)
sp|Q7YQL3|PAK3_PONPY Serine/threonine-protein kinase PAK 3 (p21-activated kinase 3)
(PAK-3)
sp|Q7YQL4|PAK3_PANTR Serine/threonine-protein kinase PAK 3 (p21-activated kinase 3)
(PAK-3)
Length = 559
Score = 111 bits (277), Expect = 2e-24
Identities = 63/196 (32%), Positives = 102/196 (52%), Gaps = 1/196 (0%)
Frame = +3
Query: 24 GKASYIKLDYMANGSLRSWLHKNGAQKEPSIIRFSKQILEALDFLHSQNILHRDLKGPKI 203
G ++ ++Y+A GSL + + E I ++ L+ALDFLHS ++HRD+K I
Sbjct: 350 GDELWVVMEYLAGGSLTDVVTET-CMDEGQIAAVCRECLQALDFLHSNQVIHRDIKSDNI 408
Query: 204 LLDNNLDIKLCGF-MSAKMFPDASSETFRNHVAESNHGTANWTAPEVINGEGYGSSADIW 380
LL + +KL F A++ P+ S + + GT W APEV+ + YG DIW
Sbjct: 409 LLGMDGSVKLTDFGFCAQITPEQSKRS-------TMVGTPYWMAPEVVTRKAYGPKVDIW 461
Query: 381 SFGAVMVELITGKAPLFFLASFQAIYRLGTQKKIEFAYPLRCSDALKSFVDPCLDPEPLN 560
S G + +E++ G+ P +A+Y + T E P R S + F++ CL+ +
Sbjct: 462 SLGIMAIEMVEGEPPYLNENPLRALYLIATNGTPELQNPERLSAVFRDFLNRCLEMDVDR 521
Query: 561 RPTVKDLMKHEFLNSA 608
R + K+L++H FL A
Sbjct: 522 RGSAKELLQHPFLKLA 537
>sp|Q61036|PAK3_MOUSE Serine/threonine-protein kinase PAK 3 (p21-activated kinase 3)
(PAK-3) (Beta-PAK) (CDC42/RAC effector kinase PAK-B)
Length = 559
Score = 111 bits (277), Expect = 2e-24
Identities = 63/196 (32%), Positives = 102/196 (52%), Gaps = 1/196 (0%)
Frame = +3
Query: 24 GKASYIKLDYMANGSLRSWLHKNGAQKEPSIIRFSKQILEALDFLHSQNILHRDLKGPKI 203
G ++ ++Y+A GSL + + E I ++ L+ALDFLHS ++HRD+K I
Sbjct: 350 GDELWVVMEYLAGGSLTDVVTET-CMDEGQIAAVCRECLQALDFLHSNQVIHRDIKSDNI 408
Query: 204 LLDNNLDIKLCGF-MSAKMFPDASSETFRNHVAESNHGTANWTAPEVINGEGYGSSADIW 380
LL + +KL F A++ P+ S + + GT W APEV+ + YG DIW
Sbjct: 409 LLGMDGSVKLTDFGFCAQITPEQSKRS-------TMVGTPYWMAPEVVTRKAYGPKVDIW 461
Query: 381 SFGAVMVELITGKAPLFFLASFQAIYRLGTQKKIEFAYPLRCSDALKSFVDPCLDPEPLN 560
S G + +E++ G+ P +A+Y + T E P R S + F++ CL+ +
Sbjct: 462 SLGIMAIEMVEGEPPYLNENPLRALYLIATNGTPELQNPERLSAVFRDFLNRCLEMDVDR 521
Query: 561 RPTVKDLMKHEFLNSA 608
R + K+L++H FL A
Sbjct: 522 RGSAKELLQHPFLKLA 537
>sp|Q9Y2U5|M3K2_HUMAN Mitogen-activated protein kinase kinase kinase 2 (MAPK/ERK kinase
kinase 2) (MEK kinase 2) (MEKK 2)
Length = 618
Score = 110 bits (276), Expect = 3e-24
Identities = 67/192 (34%), Positives = 103/192 (53%)
Frame = +3
Query: 27 KASYIKLDYMANGSLRSWLHKNGAQKEPSIIRFSKQILEALDFLHSQNILHRDLKGPKIL 206
K I ++YM GS++ L GA E ++++QILE + +LHS ILHRD+KG IL
Sbjct: 430 KTLSIFMEYMPGGSIKDQLKAYGALTENGTRKYTRQILEGVHYLHSNMILHRDIKGANIL 489
Query: 207 LDNNLDIKLCGFMSAKMFPDASSETFRNHVAESNHGTANWTAPEVINGEGYGSSADIWSF 386
D+ ++KL F ++K + +S GT W +PEVI+G+GYG ADIWS
Sbjct: 490 RDSTGNVKLGDFGASKRL---QTICLSGTGMKSVTGTPYWMSPEVISGQGYGRKADIWSV 546
Query: 387 GAVMVELITGKAPLFFLASFQAIYRLGTQKKIEFAYPLRCSDALKSFVDPCLDPEPLNRP 566
+VE++T K P + AI+++ TQ P SD + F+ L RP
Sbjct: 547 ACTVVEMLTEKPPWAEFEAMAAIFKIATQ-PTNPKLPPHVSDYTRDFLKRIFVEAKL-RP 604
Query: 567 TVKDLMKHEFLN 602
+ +L++H F++
Sbjct: 605 SADELLRHMFVH 616
>sp|Q61084|M3K3_MOUSE Mitogen-activated protein kinase kinase kinase 3 (MAPK/ERK kinase
kinase 3) (MEK kinase 3) (MEKK 3)
Length = 626
Score = 110 bits (275), Expect = 3e-24
Identities = 67/193 (34%), Positives = 104/193 (53%)
Frame = +3
Query: 18 RSGKASYIKLDYMANGSLRSWLHKNGAQKEPSIIRFSKQILEALDFLHSQNILHRDLKGP 197
R+ K I ++YM GS++ L GA E ++++QILE + +LHS I+HRD+KG
Sbjct: 434 RAEKILTIFMEYMPGGSVKDQLKAYGALTESVTRKYTRQILEGMSYLHSNMIVHRDIKGA 493
Query: 198 KILLDNNLDIKLCGFMSAKMFPDASSETFRNHVAESNHGTANWTAPEVINGEGYGSSADI 377
IL D+ ++KL F ++K + S GT W +PEVI+GEGYG AD+
Sbjct: 494 NILRDSAGNVKLGDFGASKRL---QTICMSGTGIRSVTGTPYWMSPEVISGEGYGRKADV 550
Query: 378 WSFGAVMVELITGKAPLFFLASFQAIYRLGTQKKIEFAYPLRCSDALKSFVDPCLDPEPL 557
WS G +VE++T K P + AI+++ TQ P S+ + F+ + E
Sbjct: 551 WSLGCTVVEMLTEKPPWAEYEAMAAIFKIATQ-PTNPQLPSHISEHGRDFLRR-IFVEAR 608
Query: 558 NRPTVKDLMKHEF 596
RP+ ++L+ H F
Sbjct: 609 QRPSAEELLTHHF 621
Database: Non-redundant SwissProt sequences
Posted date: Dec 6, 2005 7:40 AM
Number of letters in database: 68,354,980
Number of sequences in database: 184,735
Database: swissprot.01
Posted date: Dec 6, 2005 8:18 AM
Number of letters in database: 66,202,850
Number of sequences in database: 184,431
Lambda K H
0.318 0.134 0.401
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 86,599,404
Number of Sequences: 369166
Number of extensions: 1804103
Number of successful extensions: 7975
Number of sequences better than 10.0: 10
Number of HSP's better than 10.0 without gapping: 6106
Number of HSP's successfully gapped in prelim test: 0
Number of HSP's that attempted gapping in prelim test: 0
Number of HSP's gapped (non-prelim): 6455
length of database: 68,354,980
effective HSP length: 107
effective length of database: 48,588,335
effective search space used: 5782011865
frameshift window, decay const: 40, 0.1
T: 12
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)