Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= Dr_sW_005_P10
(752 letters)
Database: Non-redundant SwissProt sequences
184,735 sequences; 68,354,980 total letters
Score E
Sequences producing significant alignments: (bits) Value
sp|Q13614|MTMR2_HUMAN Myotubularin-related protein 2 259 7e-69
sp|Q9Z2D1|MTMR2_MOUSE Myotubularin-related protein 2 258 1e-68
sp|Q9Z2C4|MTMR1_MOUSE Myotubularin-related protein 1 245 8e-65
sp|Q9Z2C5|MTM1_MOUSE Myotubularin 244 1e-64
sp|Q13496|MTM1_HUMAN Myotubularin 244 2e-64
sp|Q13613|MTMR1_HUMAN Myotubularin-related protein 1 243 3e-64
sp|Q9Z2C9|MTMR7_MOUSE Myotubularin-related protein 7 197 2e-50
sp|Q9Y217|MTMR6_HUMAN Myotubularin-related protein 6 194 2e-49
sp|Q22712|YW91_CAEEL Hypothetical protein T24A11.1 in chrom... 176 6e-44
sp|Q9Y216|MTMR7_HUMAN Myotubularin-related protein 7 169 6e-42
>sp|Q13614|MTMR2_HUMAN Myotubularin-related protein 2
Length = 643
Score = 259 bits (661), Expect = 7e-69
Identities = 120/230 (52%), Positives = 169/230 (73%), Gaps = 1/230 (0%)
Frame = +1
Query: 1 FQRQLIESNNWRISKVNHNYEVCETYPDEVAVPKDVSDETITNACQFRTKNRFPVLCWIH 180
++RQ I + +WRI+K+N YE+C+TYP + VP ++ DE + FR++ R PVL WIH
Sbjct: 215 YRRQGIPNESWRITKINERYELCDTYPALLVVPANIPDEELKRVASFRSRGRIPVLSWIH 274
Query: 181 PDTKATLTRSSQPATGLTWKRNESDERYLKAIKDANAYNNLLTIIDARPMINARANMARG 360
P+++AT+TR SQP G++ KR++ DE+YL+AI D+NA ++ + I DARP +NA AN A+G
Sbjct: 275 PESQATITRCSQPMVGVSGKRSKEDEKYLQAIMDSNAQSHKIFIFDARPSVNAVANKAKG 334
Query: 361 GGIESQNIYTSISYDFLNIPNIHVMRESMRKLADLCYPKPDNNNWNKALEETKWLNYIRQ 540
GG ES++ Y + FL+I NIHVMRES+RKL ++ YP + +W LE T WL +I+
Sbjct: 335 GGYESEDAYQNAELVFLDIHNIHVMRESLRKLKEIVYPNIEETHWLSNLESTHWLEHIKL 394
Query: 541 ILLGSLMVAEKINS-QRSVLVHCSDGWDRTAQITSLPQLMLDPYFRTIRG 687
IL G+L +A+K+ S + SV+VHCSDGWDRTAQ+TSL LMLD Y+RTIRG
Sbjct: 395 ILAGALRIADKVESGKTSVVVHCSDGWDRTAQLTSLAMLMLDGYYRTIRG 444
>sp|Q9Z2D1|MTMR2_MOUSE Myotubularin-related protein 2
Length = 643
Score = 258 bits (659), Expect = 1e-68
Identities = 120/230 (52%), Positives = 169/230 (73%), Gaps = 1/230 (0%)
Frame = +1
Query: 1 FQRQLIESNNWRISKVNHNYEVCETYPDEVAVPKDVSDETITNACQFRTKNRFPVLCWIH 180
++RQ I + +WRI+K+N YE+C+TYP + VP ++ DE + FR++ R PVL WIH
Sbjct: 215 YRRQGIPNESWRITKINERYELCDTYPALLVVPANIPDEELKRVASFRSRGRIPVLSWIH 274
Query: 181 PDTKATLTRSSQPATGLTWKRNESDERYLKAIKDANAYNNLLTIIDARPMINARANMARG 360
P+++AT+TR SQP G++ KR++ DE+YL+AI D+NA ++ + I DARP +NA AN A+G
Sbjct: 275 PESQATVTRCSQPMVGVSGKRSKEDEKYLQAIMDSNAQSHKIFIFDARPSVNAVANKAKG 334
Query: 361 GGIESQNIYTSISYDFLNIPNIHVMRESMRKLADLCYPKPDNNNWNKALEETKWLNYIRQ 540
GG ES++ Y + FL+I NIHVMRES+RKL ++ YP + +W LE T WL +I+
Sbjct: 335 GGYESEDAYQNAELVFLDIHNIHVMRESLRKLKEIVYPTIEETHWLSNLESTHWLEHIKL 394
Query: 541 ILLGSLMVAEKINS-QRSVLVHCSDGWDRTAQITSLPQLMLDPYFRTIRG 687
IL G+L +A+K+ S + SV+VHCSDGWDRTAQ+TSL LMLD Y+RTIRG
Sbjct: 395 ILAGALRIADKVESGKTSVVVHCSDGWDRTAQLTSLAMLMLDGYYRTIRG 444
>sp|Q9Z2C4|MTMR1_MOUSE Myotubularin-related protein 1
Length = 669
Score = 245 bits (626), Expect = 8e-65
Identities = 116/230 (50%), Positives = 161/230 (70%), Gaps = 1/230 (0%)
Frame = +1
Query: 1 FQRQLIESNNWRISKVNHNYEVCETYPDEVAVPKDVSDETITNACQFRTKNRFPVLCWIH 180
++RQ + + +W+ISK+N NYE C+TYP + VP V D+ ++ FR K R PVL WIH
Sbjct: 240 YKRQGLPNESWKISKINSNYEFCDTYPAIIVVPTSVKDDDLSKVAAFRAKGRVPVLSWIH 299
Query: 181 PDTKATLTRSSQPATGLTWKRNESDERYLKAIKDANAYNNLLTIIDARPMINARANMARG 360
P+++AT+TR SQP G KR + DE+YL+ I DANA ++ LTI DAR A N A+G
Sbjct: 300 PESQATITRCSQPLVGPNDKRCKEDEKYLQTIMDANAQSHKLTIFDARQNSVADTNKAKG 359
Query: 361 GGIESQNIYTSISYDFLNIPNIHVMRESMRKLADLCYPKPDNNNWNKALEETKWLNYIRQ 540
GG E+++ Y + FL I NIHVMRES+RKL ++ YP D ++W ++ T WL YIR
Sbjct: 360 GGYENESAYPNAELIFLEIHNIHVMRESLRKLKEIVYPSIDESHWLSNVDGTHWLEYIRV 419
Query: 541 ILLGSLMVAEKINS-QRSVLVHCSDGWDRTAQITSLPQLMLDPYFRTIRG 687
+L G++ +A+KI S + SV++HCSDGWDRT+Q+TSL LMLD Y+RTI+G
Sbjct: 420 LLAGAVRIADKIESGKTSVVIHCSDGWDRTSQLTSLAMLMLDSYYRTIKG 469
>sp|Q9Z2C5|MTM1_MOUSE Myotubularin
Length = 603
Score = 244 bits (624), Expect = 1e-64
Identities = 114/230 (49%), Positives = 161/230 (70%), Gaps = 1/230 (0%)
Frame = +1
Query: 1 FQRQLIESNNWRISKVNHNYEVCETYPDEVAVPKDVSDETITNACQFRTKNRFPVLCWIH 180
++RQ + +++WRIS +N YE+CETYP + VP SD+ + FR++NR PVL WIH
Sbjct: 173 YRRQGLPNHHWRISFINKCYELCETYPALLVVPYRTSDDDLRRIATFRSRNRLPVLSWIH 232
Query: 181 PDTKATLTRSSQPATGLTWKRNESDERYLKAIKDANAYNNLLTIIDARPMINARANMARG 360
P+ K + R SQP G++ KRN+ DE+YL I++ N + L I DARP +NA AN A G
Sbjct: 233 PENKMVIMRCSQPLVGMSGKRNKDDEKYLDVIRETNKQTSKLMIYDARPSVNAVANKATG 292
Query: 361 GGIESQNIYTSISYDFLNIPNIHVMRESMRKLADLCYPKPDNNNWNKALEETKWLNYIRQ 540
GG ES + Y + FL+I NIHVMRES++K+ D+ YP + ++W +LE T WL +I+
Sbjct: 293 GGYESDDAYQNSELSFLDIHNIHVMRESLKKVKDIVYPNIEESHWLSSLESTHWLEHIKL 352
Query: 541 ILLGSLMVAEKINS-QRSVLVHCSDGWDRTAQITSLPQLMLDPYFRTIRG 687
+L G++ VA++++S + SVLVHCSDGWDRTAQ+TSL LMLD ++RTI G
Sbjct: 353 VLTGAIQVADQVSSGKSSVLVHCSDGWDRTAQLTSLAMLMLDSFYRTIEG 402
>sp|Q13496|MTM1_HUMAN Myotubularin
Length = 603
Score = 244 bits (622), Expect = 2e-64
Identities = 113/230 (49%), Positives = 162/230 (70%), Gaps = 1/230 (0%)
Frame = +1
Query: 1 FQRQLIESNNWRISKVNHNYEVCETYPDEVAVPKDVSDETITNACQFRTKNRFPVLCWIH 180
++RQ + +++WRI+ +N YE+C+TYP + VP SD+ + FR++NR PVL WIH
Sbjct: 173 YRRQGLPNHHWRITFINKCYELCDTYPALLVVPYRASDDDLRRVATFRSRNRIPVLSWIH 232
Query: 181 PDTKATLTRSSQPATGLTWKRNESDERYLKAIKDANAYNNLLTIIDARPMINARANMARG 360
P+ K + R SQP G++ KRN+ DE+YL I++ N + LTI DARP +NA AN A G
Sbjct: 233 PENKTVIVRCSQPLVGMSGKRNKDDEKYLDVIRETNKQISKLTIYDARPSVNAVANKATG 292
Query: 361 GGIESQNIYTSISYDFLNIPNIHVMRESMRKLADLCYPKPDNNNWNKALEETKWLNYIRQ 540
GG ES + Y + FL+I NIHVMRES++K+ D+ YP + ++W +LE T WL +I+
Sbjct: 293 GGYESDDAYHNAELFFLDIHNIHVMRESLKKVKDIVYPNVEESHWLSSLESTHWLEHIKL 352
Query: 541 ILLGSLMVAEKINS-QRSVLVHCSDGWDRTAQITSLPQLMLDPYFRTIRG 687
+L G++ VA+K++S + SVLVHCSDGWDRTAQ+TSL LMLD ++R+I G
Sbjct: 353 VLTGAIQVADKVSSGKSSVLVHCSDGWDRTAQLTSLAMLMLDSFYRSIEG 402
>sp|Q13613|MTMR1_HUMAN Myotubularin-related protein 1
Length = 665
Score = 243 bits (621), Expect = 3e-64
Identities = 117/230 (50%), Positives = 157/230 (68%), Gaps = 1/230 (0%)
Frame = +1
Query: 1 FQRQLIESNNWRISKVNHNYEVCETYPDEVAVPKDVSDETITNACQFRTKNRFPVLCWIH 180
++RQ + + +W+ISK+N NYE C+TYP + VP V D+ ++ FR K R PVL WIH
Sbjct: 236 YKRQGLPNESWKISKINSNYEFCDTYPAIIVVPTSVKDDDLSKVAAFRAKGRVPVLSWIH 295
Query: 181 PDTKATLTRSSQPATGLTWKRNESDERYLKAIKDANAYNNLLTIIDARPMINARANMARG 360
P+++AT+TR SQP G KR + DE+YL+ I DANA ++ L I DAR A N +G
Sbjct: 296 PESQATITRCSQPLVGPNDKRCKEDEKYLQTIMDANAQSHKLIIFDARQNSVADTNKTKG 355
Query: 361 GGIESQNIYTSISYDFLNIPNIHVMRESMRKLADLCYPKPDNNNWNKALEETKWLNYIRQ 540
GG ES++ Y + FL I NIHVMRES+RKL ++ YP D W ++ T WL YIR
Sbjct: 356 GGYESESAYPNAELVFLEIHNIHVMRESLRKLKEIVYPSIDEARWLSNVDGTHWLEYIRM 415
Query: 541 ILLGSLMVAEKINS-QRSVLVHCSDGWDRTAQITSLPQLMLDPYFRTIRG 687
+L G++ +A+KI S + SV+VHCSDGWDRTAQ+TSL LMLD Y+RTI+G
Sbjct: 416 LLAGAVRIADKIESGKTSVVVHCSDGWDRTAQLTSLAMLMLDSYYRTIKG 465
>sp|Q9Z2C9|MTMR7_MOUSE Myotubularin-related protein 7
Length = 660
Score = 197 bits (502), Expect = 2e-50
Identities = 94/231 (40%), Positives = 156/231 (67%), Gaps = 2/231 (0%)
Frame = +1
Query: 1 FQRQLIESNNWRISKVNHNYEVCETYPDEVAVPKDVSDETITNACQFRTKNRFPVLCWIH 180
++R + N W++S VN +Y VC++YP E+ VP+ + I + +FR++ RFP L +
Sbjct: 136 YKRMGLPDNYWQLSDVNRDYRVCDSYPTELYVPRSATAHIIVGSSKFRSRRRFPALSYYC 195
Query: 181 PDTKATLTRSSQPATGLTWKRNESDERYLKAIKDANAYNNLLTIIDARPMINARANMARG 360
D+ A++ RSSQP +G + + E DE+ L+AI+ AN ++ + ++D RP +NA AN A G
Sbjct: 196 KDSHASICRSSQPLSGFSARCLE-DEQMLQAIRKANPGSDFIYVVDTRPKLNAMANRAAG 254
Query: 361 GGIESQNIYTSISYDFLNIPNIHVMRESMRKLADLCYPK-PDNNNWNKALEETKWLNYIR 537
G E+++ Y++I + F+ I NIHVMR S++K+ ++C K P +++ LE + WL +I+
Sbjct: 255 KGYENEDNYSNIKFQFIGIENIHVMRNSLQKMLEVCELKSPSMSDFLWGLENSGWLRHIK 314
Query: 538 QILLGSLMVAEKINSQ-RSVLVHCSDGWDRTAQITSLPQLMLDPYFRTIRG 687
I+ + +A+ ++ + SVLVHCSDGWDRTAQ+ S+ L+LDPY+RT++G
Sbjct: 315 AIMDAGIFIAKAVSEEGASVLVHCSDGWDRTAQVCSVASLLLDPYYRTLKG 365
>sp|Q9Y217|MTMR6_HUMAN Myotubularin-related protein 6
Length = 621
Score = 194 bits (493), Expect = 2e-49
Identities = 97/231 (41%), Positives = 151/231 (65%), Gaps = 2/231 (0%)
Frame = +1
Query: 1 FQRQLIESNNWRISKVNHNYEVCETYPDEVAVPKDVSDETITNACQFRTKNRFPVLCWIH 180
++R + +++W++S N +Y++CETYP E+ VP+ S I + +FR+K RFPVL + H
Sbjct: 134 YKRMGVPNSHWQLSDANRDYKICETYpreLYVPRIASKPIIVGSSKFRSKGRFPVLSYYH 193
Query: 181 PDTKATLTRSSQPATGLTWKRNESDERYLKAIKDANAYNNLLTIIDARPMINARANMARG 360
D +A + R SQP +G + R DE L+AI AN N + ++D RP +NA AN A G
Sbjct: 194 QDKEAAICRCSQPLSGFS-ARCLEDEHLLQAISKANPVNRYMYVMDTRPKLNAMANRAAG 252
Query: 361 GGIESQNIYTSISYDFLNIPNIHVMRESMRKLADLCYPKP-DNNNWNKALEETKWLNYIR 537
G E+++ Y++I + F+ I NIHVMR S++KL ++ K N++ LE + WL +I+
Sbjct: 253 KGYENEDNYSNIRFQFVGIENIHVMRSSLQKLLEVNGTKGLSVNDFYSGLESSGWLRHIK 312
Query: 538 QILLGSLMVAEKINSQR-SVLVHCSDGWDRTAQITSLPQLMLDPYFRTIRG 687
++ ++ +A+ I + SVLVHCSDGWDRT+Q+ SL L+LD Y+RTI+G
Sbjct: 313 AVMDAAVFLAKAITVENASVLVHCSDGWDRTSQVCSLGSLLLDSYYRTIKG 363
>sp|Q22712|YW91_CAEEL Hypothetical protein T24A11.1 in chromosome III
Length = 938
Score = 176 bits (446), Expect = 6e-44
Identities = 88/226 (38%), Positives = 132/226 (58%), Gaps = 4/226 (1%)
Frame = +1
Query: 22 SNNWRISKVNHNYEVCETYPDEVAVPKDVSDETITNACQFRTKNRFPVLCWIHPDTKATL 201
S +++IS VN N+EVC TYP+++ VPK ++D+ I +R+ RFP + W T+A L
Sbjct: 261 SEHFQISSVNENFEVCPTYPEKIIVPKGITDDDIRKGAPYRSIGRFPAVIWRCRKTRAVL 320
Query: 202 TRSSQPATGLTWKRNESDERYL----KAIKDANAYNNLLTIIDARPMINARANMARGGGI 369
RSSQP G+ RN +DE+ + KA + I+DAR +A AN AR GG
Sbjct: 321 MRSSQPQVGILSWRNPTDEKIIEEAVKASRIEGEEKKQFIIMDARGYTSAFANRARSGGF 380
Query: 370 ESQNIYTSISYDFLNIPNIHVMRESMRKLADLCYPKPDNNNWNKALEETKWLNYIRQILL 549
E+ Y +FL +PNIH +R S + + + N +L+ T WL + +L+
Sbjct: 381 ENTEYYQQAKLEFLGLPNIHAVRGSFNNVRTMLHNLGPNEQLLTSLQTTGWLLNLSNLLV 440
Query: 550 GSLMVAEKINSQRSVLVHCSDGWDRTAQITSLPQLMLDPYFRTIRG 687
+ A+ ++ SVLVHCSDGWDRT Q+T+L ++MLD Y+RT++G
Sbjct: 441 NAANCADHLSKGHSVLVHCSDGWDRTTQVTTLAKIMLDEYYRTVKG 486
>sp|Q9Y216|MTMR7_HUMAN Myotubularin-related protein 7
Length = 391
Score = 169 bits (429), Expect = 6e-42
Identities = 83/200 (41%), Positives = 136/200 (68%), Gaps = 2/200 (1%)
Frame = +1
Query: 94 VPKDVSDETITNACQFRTKNRFPVLCWIHPDTKATLTRSSQPATGLTWKRNESDERYLKA 273
VPK + I + +FR++ RFPVL + + D A++ RSSQP +G + + E DE+ L+A
Sbjct: 3 VPKSATAHIIVGSSKFRSRRRFPVLSYYYKDNHASICRSSQPLSGFSARCLE-DEQMLQA 61
Query: 274 IKDANAYNNLLTIIDARPMINARANMARGGGIESQNIYTSISYDFLNIPNIHVMRESMRK 453
I+ AN ++ + ++D RP +NA AN A G G E+++ Y++I + F+ I NIHVMR S++K
Sbjct: 62 IRKANPGSDFVYVVDTRPKLNAMANRAAGKGYENEDNYSNIKFQFIGIENIHVMRNSLQK 121
Query: 454 LADLCYPK-PDNNNWNKALEETKWLNYIRQILLGSLMVAEKINSQ-RSVLVHCSDGWDRT 627
+ ++C K P +++ LE + WL +I+ I+ + +A+ ++ + SVLVHCSDGWDRT
Sbjct: 122 MLEVCELKSPSMSDFLWGLENSGWLRHIKAIMDAGIFIAKAVSEEGASVLVHCSDGWDRT 181
Query: 628 AQITSLPQLMLDPYFRTIRG 687
AQ+ S+ L+LDP++RT++G
Sbjct: 182 AQVCSVASLLLDPHYRTLKG 201
Database: Non-redundant SwissProt sequences
Posted date: Dec 6, 2005 7:40 AM
Number of letters in database: 68,354,980
Number of sequences in database: 184,735
Database: swissprot.01
Posted date: Dec 6, 2005 8:18 AM
Number of letters in database: 66,202,850
Number of sequences in database: 184,431
Lambda K H
0.318 0.134 0.401
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 81,945,446
Number of Sequences: 369166
Number of extensions: 1555339
Number of successful extensions: 3905
Number of sequences better than 10.0: 10
Number of HSP's better than 10.0 without gapping: 3785
Number of HSP's successfully gapped in prelim test: 0
Number of HSP's that attempted gapping in prelim test: 0
Number of HSP's gapped (non-prelim): 3875
length of database: 68,354,980
effective HSP length: 108
effective length of database: 48,403,600
effective search space used: 6873311200
frameshift window, decay const: 40, 0.1
T: 12
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)