Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= Dr_sW_005_P08
(933 letters)
Database: Non-redundant SwissProt sequences
184,735 sequences; 68,354,980 total letters
Score E
Sequences producing significant alignments: (bits) Value
sp|Q94887|NRX4_DROME Neurexin-4 precursor (Neurexin IV) 173 7e-43
sp|Q99P47|CNTP4_MOUSE Contactin-associated protein-like 4 p... 120 5e-27
sp|Q9C0A0|CNTP4_HUMAN Contactin-associated protein-like 4 p... 115 1e-25
sp|Q9BZ76|CNTP3_HUMAN Contactin-associated protein-like 3 p... 112 2e-24
sp|Q9CPW0|CNTP2_MOUSE Contactin-associated protein-like 2 p... 109 1e-23
sp|Q9UHC6|CNTP2_HUMAN Contactin-associated protein-like 2 p... 105 1e-22
sp|Q5RD64|CNTP2_PONPY Contactin-associated protein-like 2 p... 105 2e-22
sp|P97846|CNTP1_RAT Contactin-associated protein 1 precurso... 102 2e-21
sp|P78357|CNTP1_HUMAN Contactin-associated protein 1 precur... 102 2e-21
sp|O54991|CNTP1_MOUSE Contactin-associated protein 1 precur... 99 1e-20
>sp|Q94887|NRX4_DROME Neurexin-4 precursor (Neurexin IV)
Length = 1284
Score = 173 bits (438), Expect = 7e-43
Identities = 98/274 (35%), Positives = 141/274 (51%), Gaps = 2/274 (0%)
Frame = +3
Query: 3 GPLRCTGDSLFDNTITFTKHDAVINLPPLFAENEFDMIFLFKTTVANAVILQSVSKLNGQ 182
GPLRC GD LF N +TF DA INLPP + D+ F+TT N+VI + +
Sbjct: 784 GPLRCEGDDLFSNVVTFRIADASINLPPFDMGHSGDIYLEFRTTQENSVIFHATGPTD-- 841
Query: 183 FFEVRIREGFTLRVTFXXXXXXXXXXXXXXXXX-DNFWHVVRFERNRKESRLILDENAPV 359
+ ++ + G L+ + DN WH V ERNRKE+RL++D +
Sbjct: 842 YIKLSLNGGNKLQFQYQAGSGPLGVNVGTSYHLNDNNWHTVSVERNRKEARLVVDGSIKA 901
Query: 360 THSEDPDRPFTTFNFDSDLLLGSSQSFTDGYVGCFSNLIVNGVVQDLKS-AITDYYGISN 536
E P P + SDL++G++ + DGYVGC L++NG + DLK + YGIS
Sbjct: 902 EVREPPG-PVRALHLTSDLVIGATTEYRDGYVGCIRALLLNGKMVDLKEYSKRGLYGIST 960
Query: 537 GCNPKCNSKPCLNRGECYEMYSGYYCECGLTPYRGYVCGREVGASFIDGSALEIKLDYFD 716
GC +C S PCLN G C E Y GY C+C + ++G +C E+G + S I+ ++
Sbjct: 961 GCVGRCESNPCLNNGTCIERYDGYSCDCRWSAFKGPICADEIGVNLRSSSI--IRYEFEG 1018
Query: 717 QKISTLEEYIEIGFKRKINKGHYYKLAAMITKVY 818
ST+ E I +GF I KG ++ +T Y
Sbjct: 1019 SFRSTIAENIRVGFTTTIPKGFLLGFSSNLTGEY 1052
Score = 47.0 bits (110), Expect = 8e-05
Identities = 51/217 (23%), Positives = 83/217 (38%), Gaps = 15/217 (6%)
Frame = +3
Query: 45 ITFTKHDAVINLPPLFAENEFDMIFLFKTTVANAVILQSVSKLNGQFFEVRIREGFTLRV 224
+TFT + + L ++ F F+T V+L +G + +V + G
Sbjct: 377 VTFTTRSSFVRLKGYENSQRLNVSFYFRTYEETGVMLHH-DFYSGGYLKVFLEFGKVKID 435
Query: 225 TFXXXXXXXXXXXXXXXXXDNFWH--VVRFERNRKESRLILDENAPVTHSEDPDRPFTTF 398
D WH V+ E+NR LIL+ + RP TT
Sbjct: 436 LKVKDKARIILDNYDDQFNDGKWHSFVISIEKNR----LILNID---------QRPMTTT 482
Query: 399 NFDSDLLLGSSQSFT-----DGYVGCFSNLIVNG---VVQDLKSAITDYYG---ISNGCN 545
+ G+ +G+VGC + V+G + QD G + + C
Sbjct: 483 K-SMQVATGAQYYIAGGKDKNGFVGCMRLISVDGNYKLPQDWVKGEEVCCGDDVVVDACQ 541
Query: 546 --PKCNSKPCLNRGECYEMYSGYYCECGLTPYRGYVC 650
+CN PC ++G C++ ++C+CG T Y G VC
Sbjct: 542 MIDRCNPNPCQHKGLCHQNSREFFCDCGHTGYAGAVC 578
Score = 42.4 bits (98), Expect = 0.002
Identities = 31/123 (25%), Positives = 50/123 (40%), Gaps = 6/123 (4%)
Frame = +3
Query: 123 FKTTVANAVILQSVSKLNGQFFEVRIREGFTLRVTFXXXXXXXXXXXXXXXXXDNFWHVV 302
F TT+ +L S L G++ ++I LR F +H +
Sbjct: 1032 FTTTIPKGFLLGFSSNLTGEYLTIQISNSGHLRCVFDFGFERQEIIFPKKHFGLGQYHDM 1091
Query: 303 RFERNRKESRLIL--DENAPVTHSED----PDRPFTTFNFDSDLLLGSSQSFTDGYVGCF 464
F R S ++L D PV ++ D D F + + +G ++S TDG+VGC
Sbjct: 1092 HFMRKNGGSTVVLKVDNYEPVEYNFDIKASADAQFNNIQY---MYIGKNESMTDGFVGCV 1148
Query: 465 SNL 473
S +
Sbjct: 1149 SRV 1151
Score = 35.4 bits (80), Expect = 0.23
Identities = 34/159 (21%), Positives = 64/159 (40%), Gaps = 6/159 (3%)
Frame = +3
Query: 24 DSLFDNTITFTKHDAVINLPPLFAENEFDMIFLFKTTVANAVILQSVSKLNGQFFEVRIR 203
++L+ N ++D + P+ + E + F FKT AN V++ S G ++ ++++
Sbjct: 190 ENLYFNGTGLVRYD--LRREPITSTKE-SIRFRFKTAFANGVMMYSRGT-QGDYYALQLK 245
Query: 204 EGFTLRVTFXXXXXXXXXXXXXXXXXDNFWHVVRFERNRKESRLILDENAPVTHSEDPDR 383
+ + + DN WH V RN+++ +D V
Sbjct: 246 DN-KMVLNLDLGSRVMTSLSVGSLLDDNVWHDVVISRNQRDIIFSVDR---VIVRGRIQG 301
Query: 384 PFTTFNFDSDLLLGSSQSFTDGYV------GCFSNLIVN 482
FT N + +L LG + +G + GC N+ N
Sbjct: 302 EFTRLNLNRELYLGGVPNVQEGLIVQQNFSGCLENIYFN 340
>sp|Q99P47|CNTP4_MOUSE Contactin-associated protein-like 4 precursor (Cell recognition
molecule Caspr4)
Length = 1310
Score = 120 bits (301), Expect = 5e-27
Identities = 72/233 (30%), Positives = 111/233 (47%), Gaps = 3/233 (1%)
Frame = +3
Query: 3 GPLRCTGDSLFDNTITFTKHDAVINLPPLFAENEFDMIFLFKTTVANAVILQSVSKLNGQ 182
GPL C GD F N +F + ++ P E D+ F FKTT + V L+++ +
Sbjct: 783 GPLLCRGDRPFWNAASFNTEASYLHFPTFHGELSADVSFFFKTTALSGVFLENLGITD-- 840
Query: 183 FFEVRIREGFTLRVTFXXXXXXXXXXXXXXXXX-DNFWHVVRFERNRKESRLILDENAPV 359
F + +R T+ +F DN WH VR ERN KE+ L +DE P
Sbjct: 841 FIRIELRSPTTVTFSFDVGNGPFELSVHSPTHFNDNQWHHVRVERNMKEASLRVDELPPK 900
Query: 360 THSEDPDRPFTTFNFDSDLLLGSSQSFTDGYVGCFSNLIVNGVVQDLKSAITDYYGISNG 539
+ D +S L +G + + G++GC +L +NG+ DL+ T G+ G
Sbjct: 901 IQAAPTDG-HVLLQLNSQLFVGGTATRQRGFLGCIRSLQLNGMALDLEERATVTPGVQPG 959
Query: 540 CNPKCNS--KPCLNRGECYEMYSGYYCECGLTPYRGYVCGREVGASFIDGSAL 692
C C S K C + G+C E SG++C+C + + G C +E+ A F GS++
Sbjct: 960 CRGHCGSYGKLCRHGGKCREKPSGFFCDCSSSAFAGPFCSKEISAYFGSGSSV 1012
Score = 48.1 bits (113), Expect = 3e-05
Identities = 50/219 (22%), Positives = 88/219 (40%), Gaps = 13/219 (5%)
Frame = +3
Query: 45 ITFTKHDAVINLPPLFAENEFDMIFLFKTTVANAVILQSVSKLNGQFFEVRIREGFTLRV 224
+TF + + LP E F F+T ++L S +L + + +G L++
Sbjct: 374 LTFLSPRSYLVLPASTKEEAISASFQFRTWNKAGLLLFSELQLVSGSLLLLLSDG-KLKL 432
Query: 225 TFXXXXXXXXXXXXXXXXXDNFWHVVRFERNRKESRLILDEN-APVTHSEDPDRPFT--T 395
T D WH V R +++D + +P + P++ +
Sbjct: 433 TLYQPGKSPSDITAGAGLGDGQWHSVSLSAKRNHLSVVVDGHISPASPWLGPEQVNSGGV 492
Query: 396 FNFDS--DLLLGSS-QSFTDGYVGCFSNLIVNGVVQDL----KSAITDYYGI---SNGCN 545
F F D GS +S G+ GC + +N + DL + A+ ++ + S G +
Sbjct: 493 FYFGGCPDKGFGSKCKSPLGGFQGCMRLISINNKMVDLIAVQQGALGNFSDLQIDSCGIS 552
Query: 546 PKCNSKPCLNRGECYEMYSGYYCECGLTPYRGYVCGREV 662
+C C + GEC + +S ++C C T Y G C V
Sbjct: 553 DRCLPNSCEHGGECSQSWSTFHCNCTNTGYTGATCHSSV 591
>sp|Q9C0A0|CNTP4_HUMAN Contactin-associated protein-like 4 precursor (Cell recognition
molecule Caspr4)
Length = 1308
Score = 115 bits (289), Expect = 1e-25
Identities = 70/233 (30%), Positives = 108/233 (46%), Gaps = 3/233 (1%)
Frame = +3
Query: 3 GPLRCTGDSLFDNTITFTKHDAVINLPPLFAENEFDMIFLFKTTVANAVILQSVSKLNGQ 182
GPL C GD F N+ +F + ++ P E D+ F FKTT ++ V L+++
Sbjct: 781 GPLLCRGDRSFWNSASFDTEASYLHFPTFHGELSADVSFFFKTTASSGVFLENLG--IAD 838
Query: 183 FFEVRIREGFTLRVTF-XXXXXXXXXXXXXXXXXDNFWHVVRFERNRKESRLILDENAPV 359
F + +R + +F DN WH VR ERN KE+ L +D+ P
Sbjct: 839 FIRIELRSPTVVTFSFDVGNGPFEISVQSPTHFNDNQWHHVRVERNMKEASLQVDQLTPK 898
Query: 360 THSEDPDRPFTTFNFDSDLLLGSSQSFTDGYVGCFSNLIVNGVVQDLKSAITDYYGISNG 539
T D +S L +G + + G++GC +L +NG+ DL+ + G
Sbjct: 899 TQPAPAD-GHVLLQLNSQLFVGGTATRQRGFLGCIRSLQLNGMTLDLEERAQVTPEVQPG 957
Query: 540 CNPKCNS--KPCLNRGECYEMYSGYYCECGLTPYRGYVCGREVGASFIDGSAL 692
C C+S K C N G+C E G++C+C + Y G C E+ A F GS++
Sbjct: 958 CRGHCSSYGKLCRNGGKCRERPIGFFCDCTFSAYTGPFCSNEISAYFGSGSSV 1010
Score = 52.0 bits (123), Expect = 2e-06
Identities = 51/219 (23%), Positives = 85/219 (38%), Gaps = 13/219 (5%)
Frame = +3
Query: 45 ITFTKHDAVINLPPLFAENEFDMIFLFKTTVANAVILQSVSKLNGQFFEVRIREGFTLRV 224
+TF + + LP E E F F+T ++L S +L + + +G L+
Sbjct: 372 VTFLSSRSYLALPDFSGEEEVSATFQFRTWNKAGLLLFSELQLISGGILLFLSDG-KLKS 430
Query: 225 TFXXXXXXXXXXXXXXXXXDNFWHVVRFERNRKESRLILD-ENAPVTHSEDPDRPFT--T 395
D WH V + + +D + A P++ ++ T
Sbjct: 431 NLYQPGKLPSDITAGVELNDGQWHSVSLSAKKNHLSVAVDGQMASAAPLLGPEQIYSGGT 490
Query: 396 FNFDS--DLLLGSS-QSFTDGYVGCFSNLIVNGVVQDLKSA-------ITDYYGISNGCN 545
+ F D GS +S G+ GC + ++G V DL S +D S G +
Sbjct: 491 YYFGGCPDKSFGSKCKSPLGGFQGCMRLISISGKVVDLISVQQGSLGNFSDLQIDSCGIS 550
Query: 546 PKCNSKPCLNRGECYEMYSGYYCECGLTPYRGYVCGREV 662
+C C + GEC + +S ++C C T YRG C +
Sbjct: 551 DRCLPNYCEHGGECSQSWSTFHCNCTNTGYRGATCHNSI 589
Score = 32.0 bits (71), Expect = 2.6
Identities = 23/76 (30%), Positives = 31/76 (40%), Gaps = 7/76 (9%)
Frame = +3
Query: 282 DNFWHVVRFERNRKESRLILDENAPVTHSEDPDRPFTTFNFDSDLLL------GSSQSFT 443
D WH V +R K+ +DE+ H+ F N D ++ G S SF
Sbjct: 269 DQHWHSVLIQRLGKQVNFTVDEHRHHFHARG---EFNLMNLDYEISFGGIPAPGKSVSFP 325
Query: 444 D-GYVGCFSNLIVNGV 488
+ GC NL NGV
Sbjct: 326 HRNFHGCLENLYYNGV 341
>sp|Q9BZ76|CNTP3_HUMAN Contactin-associated protein-like 3 precursor (Cell recognition
molecule Caspr3)
Length = 1288
Score = 112 bits (279), Expect = 2e-24
Identities = 74/249 (29%), Positives = 112/249 (44%), Gaps = 3/249 (1%)
Frame = +3
Query: 3 GPLRCTGDSLFDNTITFTKHDAVINLPPLFAENEFDMIFLFKTTVANAVILQSVSKLNGQ 182
GPL C GD F N+ +F + ++ P E D+ F FKTTV++ V ++++ +
Sbjct: 781 GPLLCRGDQSFWNSASFNTETSYLHFPAFHGELTADVCFFFKTTVSSGVFMENLGITD-- 838
Query: 183 FFEVRIREGFTLRVTF-XXXXXXXXXXXXXXXXXDNFWHVVRFERNRKESRLILDENAPV 359
F + +R + +F DN WH VR ERN K + L +D+ P
Sbjct: 839 FIRIELRAPTEVTFSFDVGNGPCEVTVQSPTPFNDNQWHHVRAERNVKGASLQVDQ-LPQ 897
Query: 360 THSEDPDRPFTTFNFDSDLLLGSSQSFTDGYVGCFSNLIVNGVVQDLKSAITDYYGISNG 539
P +S L +G + + G++GC +L +NGV DL+ T G+ G
Sbjct: 898 KMQPAPADGHVRLQLNSQLFIGGTATRQRGFLGCIRSLQLNGVALDLEERATVTPGVEPG 957
Query: 540 CNPKCNS--KPCLNRGECYEMYSGYYCECGLTPYRGYVCGREVGASFIDGSALEIKLDYF 713
C C++ C N G C E G C+C + Y G C E+ A F GS+ + Y
Sbjct: 958 CAGHCSTYGHLCRNGGRCREKRRGVTCDCAFSAYDGPFCSNEISAYFATGSS----MTYH 1013
Query: 714 DQKISTLEE 740
Q+ TL E
Sbjct: 1014 FQEHYTLSE 1022
Score = 41.6 bits (96), Expect = 0.003
Identities = 45/220 (20%), Positives = 78/220 (35%), Gaps = 18/220 (8%)
Frame = +3
Query: 45 ITFTKHDAVINLPPLFAENEFDMIFLFKTTVANAVILQSVSKLNGQFFEVRIREGFTLRV 224
+TF + + LP E++ + F F+T +L + F + +++G L++
Sbjct: 372 VTFLSSRSYLALPGNSGEDKVSVTFQFRTWNRAGHLLFGELRRGSGSFVLFLKDG-KLKL 430
Query: 225 TFXXXXXXXXXXXXXXXXXDNFWHVVRFERNRKESRLILDENAPVTHSEDPDRPFTTFNF 404
+ D WH V F +++D++ V +P
Sbjct: 431 SLFQPGQSPRNVTAGAGLNDGQWHSVSFSAKWSHMNVVVDDDTAV-------QPLVAVLI 483
Query: 405 DS----------DLLLGSS-QSFTDGYVGCFSNLIVNG-------VVQDLKSAITDYYGI 530
DS D GS +S G+ GC + + V Q + D
Sbjct: 484 DSGDTYYFGGCLDNSSGSGCKSPLGGFQGCLRLITIGDKAVDPILVQQGALGSFRDLQID 543
Query: 531 SNGCNPKCNSKPCLNRGECYEMYSGYYCECGLTPYRGYVC 650
S G +C C + GEC + + + C+C T Y G C
Sbjct: 544 SCGITDRCLPSYCEHGGECSQSWDTFSCDCLGTGYTGETC 583
>sp|Q9CPW0|CNTP2_MOUSE Contactin-associated protein-like 2 precursor (Cell recognition
molecule Caspr2)
Length = 1332
Score = 109 bits (273), Expect = 1e-23
Identities = 69/230 (30%), Positives = 104/230 (45%), Gaps = 3/230 (1%)
Frame = +3
Query: 3 GPLRCTGDSLFDNTITFTKHDAVINLPPLFAENEFDMIFLFKTTVANAVILQSVSKLNGQ 182
GPLRC GD + N +F + ++ E D+ F FKT + V L+++ N
Sbjct: 787 GPLRCQGDRNYWNAASFPNPSSYLHFSTFQGETSADISFYFKTLIPRGVFLENLG--NTD 844
Query: 183 FFEVRIREGFTLRVTFXXXXXXXXXXXXXXXXX-DNFWHVVRFERNRKESRLILDENAPV 359
F ++ ++ + +F D+ WH V ERN K++ L +D P
Sbjct: 845 FIKLELKSATEVSFSFDVGNGPVEIVVRSPSPLNDDQWHRVTAERNVKQASLQVDR-LPQ 903
Query: 360 THSEDPDRPFTTFNFDSDLLLGSSQSFTDGYVGCFSNLIVNGVVQDLKSAITDYYGISNG 539
+ P T S L +G + G++GC +L +NGV DL+ G +G
Sbjct: 904 QIRKAPTEGHTRLELYSQLFVGGAGG-QQGFLGCIRSLRMNGVTLDLEERAKVTSGFKSG 962
Query: 540 CNPKCNS--KPCLNRGECYEMYSGYYCECGLTPYRGYVCGREVGASFIDG 683
C+ C S C N G+C E Y GY C+C T Y G C ++VGA F +G
Sbjct: 963 CSGHCTSYGANCENGGKCIEKYHGYSCDCSNTAYDGTFCNKDVGAFFEEG 1012
Score = 30.8 bits (68), Expect = 5.7
Identities = 29/144 (20%), Positives = 50/144 (34%), Gaps = 17/144 (11%)
Frame = +3
Query: 282 DNFWHVVRFERNRKESRLILD-ENAPVTHSEDP-----DRPFTTFNFDSDLLLGSSQSFT 443
D WH VRF + L +D + A + P + F + + S +
Sbjct: 455 DGQWHEVRFLAKENFAVLTIDGDEASAVRTNSPLQVKTGEKYFFGGFLNHMNNASYSALQ 514
Query: 444 DGYVGCFSNLIVNGVVQDL-----------KSAITDYYGISNGCNPKCNSKPCLNRGECY 590
+ GC + V+ + +L + D I + C P C + G+C
Sbjct: 515 PSFQGCMQLIQVDDQLVNLYEVAQRKPGSFANVTIDMCAIIDRCVPN----HCEHGGKCS 570
Query: 591 EMYSGYYCECGLTPYRGYVCGREV 662
+ + + C C T Y G C +
Sbjct: 571 QTWDSFKCTCDETGYSGATCHNSI 594
>sp|Q9UHC6|CNTP2_HUMAN Contactin-associated protein-like 2 precursor (Cell recognition
molecule Caspr2)
Length = 1331
Score = 105 bits (263), Expect = 1e-22
Identities = 69/230 (30%), Positives = 104/230 (45%), Gaps = 3/230 (1%)
Frame = +3
Query: 3 GPLRCTGDSLFDNTITFTKHDAVINLPPLFAENEFDMIFLFKTTVANAVILQSVSKLNGQ 182
GPLRC GD + N +F + ++ E D+ F FKT V L+++ K +
Sbjct: 787 GPLRCQGDRNYWNAASFPNPSSYLHFSTFQGETSADISFYFKTLTPWGVFLENMGKED-- 844
Query: 183 FFEVRIREGFTLRVTFXXXXXXXXXXXXXXXXX-DNFWHVVRFERNRKESRLILDENAPV 359
F ++ ++ + +F D+ WH V ERN K++ L +D P
Sbjct: 845 FIKLELKSATEVSFSFDVGNGPVEIVVRSPTPLNDDQWHRVTAERNVKQASLQVDR-LPQ 903
Query: 360 THSEDPDRPFTTFNFDSDLLLGSSQSFTDGYVGCFSNLIVNGVVQDLKSAITDYYGISNG 539
+ P T S L +G + G++GC +L +NGV DL+ G +G
Sbjct: 904 QIRKAPTEGHTRLELYSQLFVGGAGG-QQGFLGCIRSLRMNGVTLDLEERAKVTSGFISG 962
Query: 540 CNPKCNS--KPCLNRGECYEMYSGYYCECGLTPYRGYVCGREVGASFIDG 683
C+ C S C N G+C E Y GY C+C T Y G C ++VGA F +G
Sbjct: 963 CSGHCTSYGTNCENGGKCLERYHGYSCDCSNTAYDGTFCNKDVGAFFEEG 1012
Score = 30.8 bits (68), Expect = 5.7
Identities = 38/218 (17%), Positives = 72/218 (33%), Gaps = 14/218 (6%)
Frame = +3
Query: 51 FTKHDAVINLPPLFAENEFDMIFLFKTTVANAVILQSVSKLNGQFFEVRIREGFT-LRVT 227
F + + +P ++ F + F F+T N +++ S N E+ + E + +
Sbjct: 377 FFNATSYLEVPGRLNQDLFSVSFQFRTWNPNGLLVFSHFADNLGNVEIDLTESKVGVHIN 436
Query: 228 FXXXXXXXXXXXXXXXXXDNFWHVVRFERNRKESRLILD-ENAPVTHSEDP-----DRPF 389
D WH VRF + L +D + A + P +
Sbjct: 437 ITQTKMSQIDISSGSGLNDGQWHEVRFLAKENFAILTIDGDEASAVRTNSPLQVKTGEKY 496
Query: 390 TTFNFDSDLLLGSSQSFTDGYVGCFSNLIVNGVVQDLKSAITDYYGISNGCN-------P 548
F + + S + GC + V+ + +L G +
Sbjct: 497 FFGGFLNQMNNSSHSVLQPSFQGCMQLIQVDDQLVNLYEVAQRKPGSFANVSIDMCAIID 556
Query: 549 KCNSKPCLNRGECYEMYSGYYCECGLTPYRGYVCGREV 662
+C C + G+C + + + C C T Y G C +
Sbjct: 557 RCVPNHCEHGGKCSQTWDSFKCTCDETGYSGATCHNSI 594
>sp|Q5RD64|CNTP2_PONPY Contactin-associated protein-like 2 precursor
Length = 1331
Score = 105 bits (262), Expect = 2e-22
Identities = 68/230 (29%), Positives = 104/230 (45%), Gaps = 3/230 (1%)
Frame = +3
Query: 3 GPLRCTGDSLFDNTITFTKHDAVINLPPLFAENEFDMIFLFKTTVANAVILQSVSKLNGQ 182
GPLRC GD + N +F + ++ E D+ F FKT V L+++ K +
Sbjct: 787 GPLRCQGDRNYWNAASFPNPSSYLHFSTFQGETSADISFYFKTLTPWGVFLENMGKED-- 844
Query: 183 FFEVRIREGFTLRVTFXXXXXXXXXXXXXXXXX-DNFWHVVRFERNRKESRLILDENAPV 359
F ++ ++ + +F D+ WH + ERN K++ L +D P
Sbjct: 845 FIKLELKSATEVSFSFDVGNGPVEIVVRSPTPLNDDQWHRITAERNVKQASLQVDR-LPQ 903
Query: 360 THSEDPDRPFTTFNFDSDLLLGSSQSFTDGYVGCFSNLIVNGVVQDLKSAITDYYGISNG 539
+ P T S L +G + G++GC +L +NGV DL+ G +G
Sbjct: 904 QIRKAPTEGHTRLELYSQLFVGGAGG-QQGFLGCIRSLRMNGVTLDLEERAKVTSGFISG 962
Query: 540 CNPKCNS--KPCLNRGECYEMYSGYYCECGLTPYRGYVCGREVGASFIDG 683
C+ C S C N G+C E Y GY C+C T Y G C ++VGA F +G
Sbjct: 963 CSGHCTSYGTNCENGGKCLERYHGYSCDCSNTAYDGTFCNKDVGAFFEEG 1012
Score = 30.4 bits (67), Expect = 7.4
Identities = 38/218 (17%), Positives = 71/218 (32%), Gaps = 14/218 (6%)
Frame = +3
Query: 51 FTKHDAVINLPPLFAENEFDMIFLFKTTVANAVILQSVSKLNGQFFEVRIREGFT-LRVT 227
F + + +P ++ F + F F+T N +++ S N E+ + E + +
Sbjct: 377 FFNATSYLEVPGRLNQDLFSVSFQFRTWNPNGLLVFSHFADNLGNVEIDLTESKVGVHIN 436
Query: 228 FXXXXXXXXXXXXXXXXXDNFWHVVRFERNRKESRLILD-ENAPVTHSEDP-----DRPF 389
D WH VRF + L +D + A + P +
Sbjct: 437 ITQTKMSQIDISSGSGLNDGQWHEVRFLAKENFAILTIDGDEASAVRTNSPLQVKTGEKY 496
Query: 390 TTFNFDSDLLLGSSQSFTDGYVGCFSNLIVNGVVQDLKSAITDYYGISNGCN-------P 548
F + + S + GC + V+ + +L G +
Sbjct: 497 FFGGFLNQMNNSSHSVLQPSFQGCMQLIQVDDQLVNLYEVAQRKPGSFANVSIDMCAIID 556
Query: 549 KCNSKPCLNRGECYEMYSGYYCECGLTPYRGYVCGREV 662
+C C G+C + + + C C T Y G C +
Sbjct: 557 RCVPNHCERGGKCSQTWDSFKCTCDETGYTGATCHNSI 594
>sp|P97846|CNTP1_RAT Contactin-associated protein 1 precursor (Caspr) (Caspr1) (Neurexin
4) (Neurexin IV) (p190) (Paranodin)
Length = 1381
Score = 102 bits (254), Expect = 2e-21
Identities = 71/244 (29%), Positives = 109/244 (44%), Gaps = 11/244 (4%)
Frame = +3
Query: 6 PLRCTGDSLFDNTITFTKHDAVINLPPLFAENEFDMIFLFKTTVANAVILQSVSKLNGQF 185
PLRC GD NTI+F + A + PP+ A + D+ F F+T+ + V L++ + G F
Sbjct: 776 PLRCYGDRNSWNTISF-RTGAALRFPPIRANHSLDVSFYFRTSAPSGVFLEN---MGGPF 831
Query: 186 FE-----VRIREGFTLRVTFXXXXXXXXXXXXXXXXX----DNFWHVVRFERNRKESRLI 338
+ VR+ + V F D+ WH+VR E N K++RL
Sbjct: 832 CQWRRPYVRVELNTSRDVVFAFDIGNGDENLTVHSDDFEFNDDEWHLVRAEINVKQARLR 891
Query: 339 LDENAPVTHSEDPDRPFTTFNFDSDLLLGSSQSFTDGYVGCFSNLIVNGVVQDLKSAITD 518
+D P P + + +D L +GS++ +VGC + +NGV +L+
Sbjct: 892 VDHR-PWVLRPMPLQTYIWLEYDQPLYVGSAELKRRPFVGCLRAMRLNGVTLNLEGRANA 950
Query: 519 YYGISNGCNPKCNSK--PCLNRGECYEMYSGYYCECGLTPYRGYVCGREVGASFIDGSAL 692
G C C PC + G C E YS Y C+C LT + G C ++G F G+ +
Sbjct: 951 SEGTFPNCTGHCTHPRFPCFHGGRCVERYSYYTCDCDLTAFDGPYCNHDIGGFFETGTWM 1010
Query: 693 EIKL 704
L
Sbjct: 1011 RYNL 1014
Score = 43.9 bits (102), Expect = 7e-04
Identities = 35/149 (23%), Positives = 55/149 (36%), Gaps = 26/149 (17%)
Frame = +3
Query: 282 DNFWHVVRFERNRKESRLILDENAPVTHSEDPDRPFTTFNFDSDLLLGSSQSF------- 440
D FWH V F + EN V +D + ++ + G+S F
Sbjct: 442 DGFWHEVNF---------VAQENHAVISIDDVEGAEVRVSYPLLIRTGTSYFFGGCPKPA 492
Query: 441 --------TDGYVGCFSNLIVNGVVQDLK-----------SAITDYYGISNGCNPKCNSK 563
+ GC L V+G + +L + D GI++ C+P
Sbjct: 493 SRWGCHSNQTAFHGCMELLKVDGQLVNLTLVEFRKLGYFAEVLFDTCGITDRCSPNM--- 549
Query: 564 PCLNRGECYEMYSGYYCECGLTPYRGYVC 650
C + G CY+ + + C C LT Y+G C
Sbjct: 550 -CEHDGRCYQSWDDFICYCELTGYKGVTC 577
>sp|P78357|CNTP1_HUMAN Contactin-associated protein 1 precursor (Caspr) (Caspr1) (Neurexin
4) (Neurexin IV) (p190)
Length = 1384
Score = 102 bits (253), Expect = 2e-21
Identities = 71/241 (29%), Positives = 108/241 (44%), Gaps = 8/241 (3%)
Frame = +3
Query: 6 PLRCTGDSLFDNTITFTKHDAVINLPPLFAENEFDMIFLFKTTVANAVILQSVSKLNGQF 185
PLRC GD NTI+F A + PP+ A + D+ F F+T+ + V L+++ Q+
Sbjct: 775 PLRCYGDRNSWNTISFHT-GAALRFPPIRANHSLDVSFYFRTSAPSGVFLENMGGPYCQW 833
Query: 186 FE--VRIREGFTLRVTFXXXXXXXXXXXXXXXXX----DNFWHVVRFERNRKESRLILDE 347
VR+ + V F D+ WH+VR E N K++RL +D
Sbjct: 834 RRPYVRVELNTSRDVVFAFDVGNGDENLTVHSDDFEFNDDEWHLVRAEINVKQARLRVDH 893
Query: 348 NAPVTHSEDPDRPFTTFNFDSDLLLGSSQSFTDGYVGCFSNLIVNGVVQDLKSAITDYYG 527
P P + + +D L +GS++ +VGC + +NGV +L+ G
Sbjct: 894 R-PWVLRPMPLQTYIWMEYDQPLYVGSAELKRRPFVGCLRAMRLNGVTLNLEGRANASEG 952
Query: 528 ISNGCNPKCNSK--PCLNRGECYEMYSGYYCECGLTPYRGYVCGREVGASFIDGSALEIK 701
S C C PC + G C E YS Y C+C LT + G C ++G F G+ +
Sbjct: 953 TSPNCTGHCAHPRLPCFHGGRCVERYSYYTCDCDLTAFDGPYCNHDIGGFFEPGTWMRYN 1012
Query: 702 L 704
L
Sbjct: 1013 L 1013
Score = 43.5 bits (101), Expect = 9e-04
Identities = 35/149 (23%), Positives = 55/149 (36%), Gaps = 26/149 (17%)
Frame = +3
Query: 282 DNFWHVVRFERNRKESRLILDENAPVTHSEDPDRPFTTFNFDSDLLLGSSQSF------- 440
D FWH V F + EN V +D + ++ + G+S F
Sbjct: 441 DGFWHEVNF---------VAQENHAVISIDDVEGAEVRVSYPLLIRTGTSYFFGGCPKPA 491
Query: 441 --------TDGYVGCFSNLIVNGVVQDLK-----------SAITDYYGISNGCNPKCNSK 563
+ GC L V+G + +L + D GI++ C+P
Sbjct: 492 SRWDCHSNQTAFHGCMELLKVDGQLVNLTLVEGRRLGFYAEVLFDTCGITDRCSPNM--- 548
Query: 564 PCLNRGECYEMYSGYYCECGLTPYRGYVC 650
C + G CY+ + + C C LT Y+G C
Sbjct: 549 -CEHDGRCYQSWDDFICYCELTGYKGETC 576
>sp|O54991|CNTP1_MOUSE Contactin-associated protein 1 precursor (Caspr) (Caspr1) (Neurexin
4) (Neurexin IV) (Paranodin) (NCP1) (MHDNIV)
Length = 1385
Score = 99.4 bits (246), Expect = 1e-20
Identities = 71/244 (29%), Positives = 107/244 (43%), Gaps = 11/244 (4%)
Frame = +3
Query: 6 PLRCTGDSLFDNTITFTKHDAVINLPPLFAENEFDMIFLFKTTVANAVILQSVSKLNGQF 185
PLRC GD NTI+F A + PP+ A + D+ F F+T+ + V L++ + G F
Sbjct: 776 PLRCYGDRNSWNTISFHT-GAALRFPPIRANHSLDVSFYFRTSAPSGVFLEN---MGGPF 831
Query: 186 FE-----VRIREGFTLRVTFXXXXXXXXXXXXXXXXX----DNFWHVVRFERNRKESRLI 338
VR+ + V F D+ WH+VR E N K++RL
Sbjct: 832 CRWRRPYVRVELNTSRDVVFAFDIGNGDENLTVHSDDFEFNDDEWHLVRAEINVKQARLR 891
Query: 339 LDENAPVTHSEDPDRPFTTFNFDSDLLLGSSQSFTDGYVGCFSNLIVNGVVQDLKSAITD 518
+D P P + + +D L +GS++ +VGC + +NGV +L+
Sbjct: 892 VDHR-PWVLRPMPLQTYIWLVYDQPLYVGSAELKRRPFVGCLRAMRLNGVTLNLEGRANA 950
Query: 519 YYGISNGCNPKCNSK--PCLNRGECYEMYSGYYCECGLTPYRGYVCGREVGASFIDGSAL 692
G C C PC + G C E YS Y C+C LT + G C ++G F G+ +
Sbjct: 951 SEGTFPNCTGHCTHPRFPCFHGGRCVERYSYYTCDCDLTAFDGPYCNHDIGGFFETGTWM 1010
Query: 693 EIKL 704
L
Sbjct: 1011 RYNL 1014
Score = 43.9 bits (102), Expect = 7e-04
Identities = 35/149 (23%), Positives = 55/149 (36%), Gaps = 26/149 (17%)
Frame = +3
Query: 282 DNFWHVVRFERNRKESRLILDENAPVTHSEDPDRPFTTFNFDSDLLLGSSQSF------- 440
D FWH V F + EN V +D + ++ + G+S F
Sbjct: 442 DGFWHEVNF---------VAQENHAVISIDDVEGAEVRVSYPLLIRTGTSYFFGGCPKPA 492
Query: 441 --------TDGYVGCFSNLIVNGVVQDLK-----------SAITDYYGISNGCNPKCNSK 563
+ GC L V+G + +L + D GI++ C+P
Sbjct: 493 SRWGCHSNQTAFHGCMELLKVDGQLVNLTLVEFRKLGYFAEVLFDTCGITDRCSPNM--- 549
Query: 564 PCLNRGECYEMYSGYYCECGLTPYRGYVC 650
C + G CY+ + + C C LT Y+G C
Sbjct: 550 -CEHDGRCYQSWDDFICYCELTGYKGVTC 577
Database: Non-redundant SwissProt sequences
Posted date: Dec 6, 2005 7:40 AM
Number of letters in database: 68,354,980
Number of sequences in database: 184,735
Database: swissprot.01
Posted date: Dec 6, 2005 8:18 AM
Number of letters in database: 66,202,850
Number of sequences in database: 184,431
Lambda K H
0.318 0.134 0.401
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 99,112,840
Number of Sequences: 369166
Number of extensions: 1920139
Number of successful extensions: 5915
Number of sequences better than 10.0: 10
Number of HSP's better than 10.0 without gapping: 4655
Number of HSP's successfully gapped in prelim test: 0
Number of HSP's that attempted gapping in prelim test: 0
Number of HSP's gapped (non-prelim): 5815
length of database: 68,354,980
effective HSP length: 110
effective length of database: 48,034,130
effective search space used: 9606826000
frameshift window, decay const: 40, 0.1
T: 12
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)