Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= Dr_sW_005_P07
(885 letters)
Database: Non-redundant SwissProt sequences
184,735 sequences; 68,354,980 total letters
Score E
Sequences producing significant alignments: (bits) Value
sp|Q16254|E2F4_HUMAN Transcription factor E2F4 (E2F-4) 173 5e-43
sp|Q15329|E2F5_HUMAN Transcription factor E2F5 (E2F-5) 171 3e-42
sp|Q61502|E2F5_MOUSE Transcription factor E2F5 (E2F-5) 170 4e-42
sp|Q62814|E2F5_RAT Transcription factor E2F5 (E2F-5) 168 2e-41
sp|O35261|E2F3_MOUSE Transcription factor E2F3 (E2F-3) 107 3e-23
sp|O00716|E2F3_HUMAN Transcription factor E2F3 (E2F-3) 107 6e-23
sp|P56931|E2F2_MOUSE Transcription factor E2F2 (E2F-2) 103 8e-22
sp|Q14209|E2F2_HUMAN Transcription factor E2F2 (E2F-2) 100 5e-21
sp|O54917|E2F6_MOUSE Transcription factor E2F6 (E2F-6) (E2F... 98 3e-20
sp|O75461|E2F6_HUMAN Transcription factor E2F6 (E2F-6) 96 1e-19
>sp|Q16254|E2F4_HUMAN Transcription factor E2F4 (E2F-4)
Length = 413
Score = 173 bits (439), Expect = 5e-43
Identities = 92/188 (48%), Positives = 125/188 (66%)
Frame = -2
Query: 884 DGSLDLKIAAEYLAVRQKRRIYDITNVLEGIGLIEKKTKNSIQWKGGSAATNSPDMQQRQ 705
DG LDLK+AA+ LAVRQKRRIYDITNVLEGIGLIEKK+KNSIQWKG N+ ++ +
Sbjct: 38 DGVLDLKLAADTLAVRQKRRIYDITNVLEGIGLIEKKSKNSIQWKGVGPGCNTREIADKL 97
Query: 704 TQLKSEVEYLDNLINKVEEHKNKLKQSIANVTEDLDNQEYAYLTHTDLINMFENKTMLVI 525
+LK+E+E L ++++HK ++QSI NVTED+ N AY+TH D+ F T+L I
Sbjct: 98 IELKAEIEELQQREQELDQHKVWVQQSIRNVTEDVQNSCLAYVTHEDICRCFAGDTLLAI 157
Query: 524 KAPQGTDVSVPLPEDPSASDAPRSLFSLKKSFQVHLKSHTTPISVLLVKQDELTSQPKLR 345
+AP GT + VP+PE + +K +Q+HLKS + PI VLLV ++ +S P
Sbjct: 158 RAPSGTSLEVPIPEGLNG----------QKKYQIHLKSVSGPIEVLLVNKEAWSSPPVAV 207
Query: 344 NVPFVDDI 321
VP +D+
Sbjct: 208 PVPPPEDL 215
Score = 33.9 bits (76), Expect = 0.62
Identities = 13/22 (59%), Positives = 17/22 (77%)
Frame = -2
Query: 173 DGDYLLILDETEGACDMFDIGV 108
D DY+ LDE+EG CD+FD+ V
Sbjct: 389 DHDYIYNLDESEGVCDLFDVPV 410
>sp|Q15329|E2F5_HUMAN Transcription factor E2F5 (E2F-5)
Length = 346
Score = 171 bits (432), Expect = 3e-42
Identities = 92/197 (46%), Positives = 128/197 (64%)
Frame = -2
Query: 884 DGSLDLKIAAEYLAVRQKRRIYDITNVLEGIGLIEKKTKNSIQWKGGSAATNSPDMQQRQ 705
DG LDLK AA+ LAVRQKRRIYDITNVLEGI LIEKK+KNSIQWKG A N+ ++ R
Sbjct: 71 DGVLDLKAAADTLAVRQKRRIYDITNVLEGIDLIEKKSKNSIQWKGVGAGCNTKEVIDRL 130
Query: 704 TQLKSEVEYLDNLINKVEEHKNKLKQSIANVTEDLDNQEYAYLTHTDLINMFENKTMLVI 525
LK+E+E L+ ++++ K L+QSI NV +D N ++Y+TH D+ N F T+L I
Sbjct: 131 RYLKAEIEDLELKERELDQQKLWLQQSIKNVMDDSINNRFSYVTHEDICNCFNGDTLLAI 190
Query: 524 KAPQGTDVSVPLPEDPSASDAPRSLFSLKKSFQVHLKSHTTPISVLLVKQDELTSQPKLR 345
+AP GT + VP+PE +K +Q++LKSH+ PI VLL+ ++ +S+P +
Sbjct: 191 QAPSGTQLEVPIPEMGQNG---------QKKYQINLKSHSGPIHVLLINKESSSSKPVVF 241
Query: 344 NVPFVDDINTNNDIKMT 294
VP DD+ + +T
Sbjct: 242 PVPPPDDLTQPSSQSLT 258
>sp|Q61502|E2F5_MOUSE Transcription factor E2F5 (E2F-5)
Length = 335
Score = 170 bits (431), Expect = 4e-42
Identities = 92/188 (48%), Positives = 125/188 (66%)
Frame = -2
Query: 884 DGSLDLKIAAEYLAVRQKRRIYDITNVLEGIGLIEKKTKNSIQWKGGSAATNSPDMQQRQ 705
DG LDLK AA+ LAVRQKRRIYDITNVLEGI LIEKK+KNSIQWKG A N+ ++ R
Sbjct: 61 DGVLDLKAAADTLAVRQKRRIYDITNVLEGIDLIEKKSKNSIQWKGVGAGCNTKEVIDRL 120
Query: 704 TQLKSEVEYLDNLINKVEEHKNKLKQSIANVTEDLDNQEYAYLTHTDLINMFENKTMLVI 525
LK+E+E L+ ++++ K L+QSI NV ED N ++Y+TH D+ N F T+L I
Sbjct: 121 RCLKAEIEDLELKERELDQQKLWLQQSIKNVMEDSINNRFSYVTHEDICNCFHGDTLLAI 180
Query: 524 KAPQGTDVSVPLPEDPSASDAPRSLFSLKKSFQVHLKSHTTPISVLLVKQDELTSQPKLR 345
+AP GT + VP+PE +K +Q++LKSH+ PI VLL+ ++ +S+P +
Sbjct: 181 QAPSGTQLEVPIPEMGQNG---------QKKYQINLKSHSGPIHVLLINKESSSSKPVVF 231
Query: 344 NVPFVDDI 321
VP DD+
Sbjct: 232 PVPPPDDL 239
>sp|Q62814|E2F5_RAT Transcription factor E2F5 (E2F-5)
Length = 300
Score = 168 bits (425), Expect = 2e-41
Identities = 91/188 (48%), Positives = 125/188 (66%)
Frame = -2
Query: 884 DGSLDLKIAAEYLAVRQKRRIYDITNVLEGIGLIEKKTKNSIQWKGGSAATNSPDMQQRQ 705
DG LDLK AA+ LAVRQKRRIYDITNVLEGI LIEKK+KNSIQWKG A N+ ++ R
Sbjct: 26 DGVLDLKAAADTLAVRQKRRIYDITNVLEGIDLIEKKSKNSIQWKGVGAGCNTKEVIDRL 85
Query: 704 TQLKSEVEYLDNLINKVEEHKNKLKQSIANVTEDLDNQEYAYLTHTDLINMFENKTMLVI 525
LK+E+E L+ ++++ K L+QSI NV ED N ++Y+TH D+ + F T+L I
Sbjct: 86 RCLKAEIEDLELKERELDQQKLWLQQSIKNVMEDSINNRFSYVTHEDICSCFNGDTLLAI 145
Query: 524 KAPQGTDVSVPLPEDPSASDAPRSLFSLKKSFQVHLKSHTTPISVLLVKQDELTSQPKLR 345
+AP GT + VP+PE +K +Q++LKSH+ PI VLL+ ++ +S+P +
Sbjct: 146 QAPSGTQLEVPIPEMGQNG---------QKKYQINLKSHSGPIHVLLINKESNSSKPVVF 196
Query: 344 NVPFVDDI 321
VP DD+
Sbjct: 197 PVPPPDDL 204
>sp|O35261|E2F3_MOUSE Transcription factor E2F3 (E2F-3)
Length = 457
Score = 107 bits (268), Expect = 3e-23
Identities = 92/271 (33%), Positives = 127/271 (46%), Gaps = 15/271 (5%)
Frame = -2
Query: 884 DGSLDLKIAAEYLAVRQKRRIYDITNVLEGIGLIEKKTKNSIQWKGGSAATNSPDMQQRQ 705
DG LDL AAE L V QKRRIYDITNVLEGI LI+KK+KN++QW G S + + + Q Q
Sbjct: 191 DGVLDLNKAAEVLKV-QKRRIYDITNVLEGIHLIKKKSKNNVQWMGCSLSEDGGMLAQCQ 249
Query: 704 TQLKSEVEYLDNLINKVEEHKNKLKQSIANVTEDLDNQEYAYLTHTDL--INMFENKTML 531
L EV L K++E + +TED +NQ AY+T+ D+ I+ +++T++
Sbjct: 250 -GLSKEVTELSQEEKKLDELIQSCTLDLKLLTEDSENQRLAYVTYQDIRKISGLKDQTVI 308
Query: 530 VIKAPQGTDVSVPLPEDPSASDAPRSLFSLKKSFQVHLKSHTTPISVLLVKQDELTSQPK 351
V+KAP T + VP D+ SL Q+HL S PI V L ++ T +P
Sbjct: 309 VVKAPPETRLEVP--------DSIESL-------QIHLASTQGPIEVYLCPEETETHRPM 353
Query: 350 LRN---------VPFVDDINTNN----DIKMTXXXXXXXXXXXXXXXXXXXEMEINXXXX 210
N P D+ +NN D ++ ++ N
Sbjct: 354 KTNNQDHNGNIPKPTSKDLASNNSGHSDCSVSTANLSPLASPANLLQQTEDQIPSN---L 410
Query: 209 XXXXXXXXXXPCDGDYLLILDETEGACDMFD 117
DYLL L E EG D+FD
Sbjct: 411 EGPFVNLLPPLLQEDYLLSLGEEEGISDLFD 441
>sp|O00716|E2F3_HUMAN Transcription factor E2F3 (E2F-3)
Length = 465
Score = 107 bits (266), Expect = 6e-23
Identities = 75/183 (40%), Positives = 102/183 (55%), Gaps = 2/183 (1%)
Frame = -2
Query: 884 DGSLDLKIAAEYLAVRQKRRIYDITNVLEGIGLIEKKTKNSIQWKGGSAATNSPDMQQRQ 705
DG LDL AAE L V QKRRIYDITNVLEGI LI+KK+KN++QW G S + + + Q Q
Sbjct: 199 DGVLDLNKAAEVLKV-QKRRIYDITNVLEGIHLIKKKSKNNVQWMGCSLSEDGGMLAQCQ 257
Query: 704 TQLKSEVEYLDNLINKVEEHKNKLKQSIANVTEDLDNQEYAYLTHTDL--INMFENKTML 531
L EV L K++E + +TED +NQ AY+T+ D+ I+ +++T++
Sbjct: 258 -GLSKEVTELSQEEKKLDELIQSCTLDLKLLTEDSENQRLAYVTYQDIRKISGLKDQTVI 316
Query: 530 VIKAPQGTDVSVPLPEDPSASDAPRSLFSLKKSFQVHLKSHTTPISVLLVKQDELTSQPK 351
V+KAP T + VP D+ SL Q+HL S PI V L ++ T P
Sbjct: 317 VVKAPPETRLEVP--------DSIESL-------QIHLASTQGPIEVYLCPEETETHSPM 361
Query: 350 LRN 342
N
Sbjct: 362 KTN 364
>sp|P56931|E2F2_MOUSE Transcription factor E2F2 (E2F-2)
Length = 443
Score = 103 bits (256), Expect = 8e-22
Identities = 68/173 (39%), Positives = 96/173 (55%), Gaps = 2/173 (1%)
Frame = -2
Query: 884 DGSLDLKIAAEYLAVRQKRRIYDITNVLEGIGLIEKKTKNSIQWKGGSAATNSPDMQQRQ 705
DG LDL AAE L V QKRRIYDITNVLEGI LI KK+KN+IQW G P RQ
Sbjct: 152 DGVLDLNWAAEVLDV-QKRRIYDITNVLEGIQLIRKKSKNNIQWV-GRELFEDPTRPSRQ 209
Query: 704 TQLKSEVEYLDNLINKVEEHKNKLKQSIANVTEDLDNQEYAYLTHTDL--INMFENKTML 531
QL E++ L N +++ S ++TED N++ AY+T+ D+ + F+ +T++
Sbjct: 210 QQLGQELKELMNAEQTLDQLIQSCSLSFKHLTEDNANKKLAYVTYQDIRAVGNFKEQTVI 269
Query: 530 VIKAPQGTDVSVPLPEDPSASDAPRSLFSLKKSFQVHLKSHTTPISVLLVKQD 372
+KAP T + VP +++ Q++LKS PI V L ++
Sbjct: 270 AVKAPPQTRLEVP--------------DRAEENLQIYLKSTQGPIEVYLCPEE 308
>sp|Q14209|E2F2_HUMAN Transcription factor E2F2 (E2F-2)
Length = 437
Score = 100 bits (249), Expect = 5e-21
Identities = 67/173 (38%), Positives = 93/173 (53%), Gaps = 2/173 (1%)
Frame = -2
Query: 884 DGSLDLKIAAEYLAVRQKRRIYDITNVLEGIGLIEKKTKNSIQWKGGSAATNSPDMQQRQ 705
DG LDL AAE L V QKRRIYDITNVLEGI LI KK KN+IQW G P +Q
Sbjct: 150 DGVLDLNWAAEVLDV-QKRRIYDITNVLEGIQLIRKKAKNNIQWV-GRGMFEDPTRPGKQ 207
Query: 704 TQLKSEVEYLDNLINKVEEHKNKLKQSIANVTEDLDNQEYAYLTHTDL--INMFENKTML 531
QL E++ L N +++ S ++TED N+ AY+T+ D+ + F+ +T++
Sbjct: 208 QQLGQELKELMNTEQALDQLIQSCSLSFKHLTEDKANKRLAYVTYQDIRAVGNFKEQTVI 267
Query: 530 VIKAPQGTDVSVPLPEDPSASDAPRSLFSLKKSFQVHLKSHTTPISVLLVKQD 372
+KAP T + VP + + Q++LKS PI V L ++
Sbjct: 268 AVKAPPQTRLEVP--------------DRTEDNLQIYLKSTQGPIEVYLCPEE 306
>sp|O54917|E2F6_MOUSE Transcription factor E2F6 (E2F-6) (E2F-binding site-modulating
activity protein) (EMA)
Length = 272
Score = 98.2 bits (243), Expect = 3e-20
Identities = 62/179 (34%), Positives = 99/179 (55%), Gaps = 2/179 (1%)
Frame = -2
Query: 881 GSLDLKIAAEYLAVRQKRRIYDITNVLEGIGLIEKKTKNSIQWKGGSAATNSPDMQQRQT 702
G LDL A L+VR KRR+YDITNVL+GI L+EKK+KN I+W G N+ +Q
Sbjct: 85 GILDLNKVATKLSVR-KRRVYDITNVLDGIELVEKKSKNHIRWIGSD--LNNFGAAPQQK 141
Query: 701 QLKSEVEYLDNLINKVEEHKNKLKQSIANVTEDLDNQEYAYLTHTDL--INMFENKTMLV 528
+L++E+ L + + ++E Q + +T+D +N+ AY+T+ D+ I F + ++
Sbjct: 142 KLQAELSDLSAMEDALDELIKDCAQQLLELTDDKENERLAYVTYQDIHGIQAFHEQIVIA 201
Query: 527 IKAPQGTDVSVPLPEDPSASDAPRSLFSLKKSFQVHLKSHTTPISVLLVKQDELTSQPK 351
+KAP+ T + VP P + S + VH++S PI V L + ++ S K
Sbjct: 202 VKAPEETRLDVPApreDSIT--------------VHIRSTKGPIDVYLCEVEQNHSNGK 246
>sp|O75461|E2F6_HUMAN Transcription factor E2F6 (E2F-6)
Length = 281
Score = 95.9 bits (237), Expect = 1e-19
Identities = 60/173 (34%), Positives = 94/173 (54%), Gaps = 2/173 (1%)
Frame = -2
Query: 881 GSLDLKIAAEYLAVRQKRRIYDITNVLEGIGLIEKKTKNSIQWKGGSAATNSPDMQQRQT 702
G LDL A L VR KRR+YDITNVL+GI L+EKK+KN I+W G + QQ+
Sbjct: 85 GILDLNKVATKLGVR-KRRVYDITNVLDGIDLVEKKSKNHIRWIGSDLSNFGAVPQQK-- 141
Query: 701 QLKSEVEYLDNLINKVEEHKNKLKQSIANVTEDLDNQEYAYLTHTDL--INMFENKTMLV 528
+L+ E+ L + + ++E Q + +T+D +N+ AY+T+ D+ I F + ++
Sbjct: 142 KLQEELSDLSAMEDALDELIKDCAQQLFELTDDKENERLAYVTYQDIHSIQAFHEQIVIA 201
Query: 527 IKAPQGTDVSVPLPEDPSASDAPRSLFSLKKSFQVHLKSHTTPISVLLVKQDE 369
+KAP T + VP P + S + VH++S PI V L + ++
Sbjct: 202 VKAPAETRLDVPApreDSIT--------------VHIRSTNGPIDVYLCEVEQ 240
Database: Non-redundant SwissProt sequences
Posted date: Dec 6, 2005 7:40 AM
Number of letters in database: 68,354,980
Number of sequences in database: 184,735
Database: swissprot.01
Posted date: Dec 6, 2005 8:18 AM
Number of letters in database: 66,202,850
Number of sequences in database: 184,431
Lambda K H
0.318 0.134 0.401
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 88,216,110
Number of Sequences: 369166
Number of extensions: 1660213
Number of successful extensions: 5317
Number of sequences better than 10.0: 10
Number of HSP's better than 10.0 without gapping: 5030
Number of HSP's successfully gapped in prelim test: 0
Number of HSP's that attempted gapping in prelim test: 0
Number of HSP's gapped (non-prelim): 5290
length of database: 68,354,980
effective HSP length: 110
effective length of database: 48,034,130
effective search space used: 8838279920
frameshift window, decay const: 40, 0.1
T: 12
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)