Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= Dr_sW_005_O18
(620 letters)
Database: Non-redundant SwissProt sequences
184,735 sequences; 68,354,980 total letters
Score E
Sequences producing significant alignments: (bits) Value
sp|P07688|CATB_BOVIN Cathepsin B precursor [Contains: Cathe... 293 3e-79
sp|P07858|CATB_HUMAN Cathepsin B precursor (Cathepsin B1) (... 290 2e-78
sp|P00787|CATB_RAT Cathepsin B precursor (Cathepsin B1) (RS... 285 9e-77
sp|P10605|CATB_MOUSE Cathepsin B precursor (Cathepsin B1) [... 280 2e-75
sp|P43233|CATB_CHICK Cathepsin B precursor (Cathepsin B1) [... 270 3e-72
sp|P43157|CYSP_SCHJA Cathepsin B-like cysteine proteinase p... 261 1e-69
sp|P25792|CYSP_SCHMA Cathepsin B-like cysteine proteinase p... 251 8e-67
sp|P43510|CPR6_CAEEL Cathepsin B-like cysteine proteinase 6... 237 2e-62
sp|P43509|CPR5_CAEEL Cathepsin B-like cysteine proteinase 5... 228 7e-60
sp|P25793|CYSP2_HAECO Cathepsin B-like cysteine proteinase ... 221 9e-58
>sp|P07688|CATB_BOVIN Cathepsin B precursor [Contains: Cathepsin B light chain; Cathepsin
B heavy chain]
Length = 335
Score = 293 bits (749), Expect = 3e-79
Identities = 127/185 (68%), Positives = 147/185 (79%)
Frame = +2
Query: 5 CGDGCNGGFPSGAWHYWVTDGLVTGGEYGAHLGCQDYAFPKCSHHVIGPYPNCTGEFPTP 184
CGDGCNGGFPSGAW++W GLV+GG Y +H+GC+ Y+ P C HHV G P CTGE TP
Sbjct: 146 CGDGCNGGFPSGAWNFWTKKGLVSGGLYNSHVGCRPYSIPPCEHHVNGSRPPCTGEGDTP 205
Query: 185 KCKKACQAGYSKTYAEDKQYGKSSYSVDSNQQAIMQEILTNGPVEAAFSVYADFPNYKSG 364
KC K C+ GYS +Y EDK +G SSYSV +N++ IM EI NGPVE AFSVY+DF YKSG
Sbjct: 206 KCNKTCEPGYSPSYKEDKHFGCSSYSVANNEKEIMAEIYKNGPVEGAFSVYSDFLLYKSG 265
Query: 365 VYQHVSGGMLGGHAIKILGWGVENNTPYWLVANSWNPTWGDNGYFKILRGSDECGIEDEV 544
VYQHVSG ++GGHAI+ILGWGVEN TPYWLV NSWN WGDNG+FKILRG D CGIE E+
Sbjct: 266 VYQHVSGEIMGGHAIRILGWGVENGTPYWLVGNSWNTDWGDNGFFKILRGQDHCGIESEI 325
Query: 545 VAGIP 559
VAG+P
Sbjct: 326 VAGMP 330
>sp|P07858|CATB_HUMAN Cathepsin B precursor (Cathepsin B1) (APP secretase) (APPS)
[Contains: Cathepsin B light chain; Cathepsin B heavy
chain]
Length = 339
Score = 290 bits (742), Expect = 2e-78
Identities = 126/186 (67%), Positives = 148/186 (79%)
Frame = +2
Query: 5 CGDGCNGGFPSGAWHYWVTDGLVTGGEYGAHLGCQDYAFPKCSHHVIGPYPNCTGEFPTP 184
CGDGCNGG+P+ AW++W GLV+GG Y +H+GC+ Y+ P C HHV G P CTGE TP
Sbjct: 146 CGDGCNGGYPAEAWNFWTRKGLVSGGLYESHVGCRPYSIPPCEHHVNGSRPPCTGEGDTP 205
Query: 185 KCKKACQAGYSKTYAEDKQYGKSSYSVDSNQQAIMQEILTNGPVEAAFSVYADFPNYKSG 364
KC K C+ GYS TY +DK YG +SYSV ++++ IM EI NGPVE AFSVY+DF YKSG
Sbjct: 206 KCSKICEPGYSPTYKQDKHYGYNSYSVSNSEKDIMAEIYKNGPVEGAFSVYSDFLLYKSG 265
Query: 365 VYQHVSGGMLGGHAIKILGWGVENNTPYWLVANSWNPTWGDNGYFKILRGSDECGIEDEV 544
VYQHV+G M+GGHAI+ILGWGVEN TPYWLVANSWN WGDNG+FKILRG D CGIE EV
Sbjct: 266 VYQHVTGEMMGGHAIRILGWGVENGTPYWLVANSWNTDWGDNGFFKILRGQDHCGIESEV 325
Query: 545 VAGIPK 562
VAGIP+
Sbjct: 326 VAGIPR 331
>sp|P00787|CATB_RAT Cathepsin B precursor (Cathepsin B1) (RSG-2) [Contains: Cathepsin B
light chain; Cathepsin B heavy chain]
Length = 339
Score = 285 bits (728), Expect = 9e-77
Identities = 120/187 (64%), Positives = 146/187 (78%)
Frame = +2
Query: 2 RCGDGCNGGFPSGAWHYWVTDGLVTGGEYGAHLGCQDYAFPKCSHHVIGPYPNCTGEFPT 181
+CGDGCNGG+PSGAW++W GLV+GG Y +H+GC Y P C HHV G P CTGE T
Sbjct: 145 QCGDGCNGGYPSGAWNFWTRKGLVSGGVYNSHIGCLPYTIPPCEHHVNGSRPPCTGEGDT 204
Query: 182 PKCKKACQAGYSKTYAEDKQYGKSSYSVDSNQQAIMQEILTNGPVEAAFSVYADFPNYKS 361
PKC K C+AGYS +Y EDK YG +SYSV +++ IM EI NGPVE AF+V++DF YKS
Sbjct: 205 PKCNKMCEAGYSTSYKEDKHYGYTSYSVSDSEKEIMAEIYKNGPVEGAFTVFSDFLTYKS 264
Query: 362 GVYQHVSGGMLGGHAIKILGWGVENNTPYWLVANSWNPTWGDNGYFKILRGSDECGIEDE 541
GVY+H +G ++GGHAI+ILGWG+EN PYWLVANSWN WGDNG+FKILRG + CGIE E
Sbjct: 265 GVYKHEAGDVMGGHAIRILGWGIENGVPYWLVANSWNVDWGDNGFFKILRGENHCGIESE 324
Query: 542 VVAGIPK 562
+VAGIP+
Sbjct: 325 IVAGIPR 331
>sp|P10605|CATB_MOUSE Cathepsin B precursor (Cathepsin B1) [Contains: Cathepsin B light
chain; Cathepsin B heavy chain]
Length = 339
Score = 280 bits (717), Expect = 2e-75
Identities = 119/187 (63%), Positives = 145/187 (77%)
Frame = +2
Query: 2 RCGDGCNGGFPSGAWHYWVTDGLVTGGEYGAHLGCQDYAFPKCSHHVIGPYPNCTGEFPT 181
+CGDGCNGG+PSGAW +W GLV+GG Y +H+GC Y P C HHV G P CTGE T
Sbjct: 145 QCGDGCNGGYPSGAWSFWTKKGLVSGGVYNSHVGCLPYTIPPCEHHVNGSRPPCTGEGDT 204
Query: 182 PKCKKACQAGYSKTYAEDKQYGKSSYSVDSNQQAIMQEILTNGPVEAAFSVYADFPNYKS 361
P+C K+C+AGYS +Y EDK +G +SYSV ++ + IM EI NGPVE AF+V++DF YKS
Sbjct: 205 PRCNKSCEAGYSPSYKEDKHFGYTSYSVSNSVKEIMAEIYKNGPVEGAFTVFSDFLTYKS 264
Query: 362 GVYQHVSGGMLGGHAIKILGWGVENNTPYWLVANSWNPTWGDNGYFKILRGSDECGIEDE 541
GVY+H +G M+GGHAI+ILGWGVEN PYWL ANSWN WGDNG+FKILRG + CGIE E
Sbjct: 265 GVYKHEAGDMMGGHAIRILGWGVENGVPYWLAANSWNLDWGDNGFFKILRGENHCGIESE 324
Query: 542 VVAGIPK 562
+VAGIP+
Sbjct: 325 IVAGIPR 331
>sp|P43233|CATB_CHICK Cathepsin B precursor (Cathepsin B1) [Contains: Cathepsin B light
chain; Cathepsin B heavy chain]
Length = 340
Score = 270 bits (689), Expect = 3e-72
Identities = 119/188 (63%), Positives = 139/188 (73%), Gaps = 1/188 (0%)
Frame = +2
Query: 5 CGDGCNGGFPSGAWHYWVTDGLVTGGEYGAHLGCQDYAFPKCSHHVIGPYPNCTGEF-PT 181
CG GCNGG+PSGAW YW GLV+GG Y +H+GC+ Y P C HHV G P CTGE T
Sbjct: 146 CGMGCNGGYPSGAWRYWTERGLVSGGLYDSHVGCRAYTIPPCEHHVNGSRPPCTGEGGET 205
Query: 182 PKCKKACQAGYSKTYAEDKQYGKSSYSVDSNQQAIMQEILTNGPVEAAFSVYADFPNYKS 361
P+C + C+ GYS +Y EDK YG +SY V +++ IM EI NGPVE AF VY DF YKS
Sbjct: 206 PRCSRHCEPGYSPSYKEDKHYGITSYGVPRSEKEIMAEIYKNGPVEGAFIVYEDFLMYKS 265
Query: 362 GVYQHVSGGMLGGHAIKILGWGVENNTPYWLVANSWNPTWGDNGYFKILRGSDECGIEDE 541
GVYQHVSG +GGHAI+ILGWGVEN TPYWL ANSWN WG G+FKILRG D CGIE E
Sbjct: 266 GVYQHVSGEQVGGHAIRILGWGVENGTPYWLAANSWNTDWGITGFFKILRGEDHCGIESE 325
Query: 542 VVAGIPKL 565
+VAG+P++
Sbjct: 326 IVAGVPRM 333
>sp|P43157|CYSP_SCHJA Cathepsin B-like cysteine proteinase precursor (Antigen Sj31)
Length = 342
Score = 261 bits (667), Expect = 1e-69
Identities = 111/187 (59%), Positives = 137/187 (73%), Gaps = 1/187 (0%)
Frame = +2
Query: 5 CGDGCNGGFPSGAWHYWVTDGLVTGGEYGAHLGCQDYAFPKCSHHVIGPYPNC-TGEFPT 181
CGDGC GGFP AW YWV G+VTGG H GCQ Y FPKC HH G YP C T + T
Sbjct: 155 CGDGCQGGFPGVAWDYWVKRGIVTGGSKENHTGCQPYPFPKCEHHTKGKYPACGTKIYKT 214
Query: 182 PKCKKACQAGYSKTYAEDKQYGKSSYSVDSNQQAIMQEILTNGPVEAAFSVYADFPNYKS 361
P+CK+ CQ GY Y +DK YG SY+V +N++ I ++I+ GPVEAAF VY DF NYKS
Sbjct: 215 PQCKQTCQKGYKTPYEQDKHYGDESYNVQNNEKVIQRDIMMYGPVEAAFDVYEDFLNYKS 274
Query: 362 GVYQHVSGGMLGGHAIKILGWGVENNTPYWLVANSWNPTWGDNGYFKILRGSDECGIEDE 541
G+Y+HV+G ++GGHAI+I+GWGVE TPYWL+ANSWN WG+ G F+++RG DEC IE +
Sbjct: 275 GIYRHVTGSIVGGHAIRIIGWGVEKRTPYWLIANSWNEDWGEKGLFRMVRGRDECSIESD 334
Query: 542 VVAGIPK 562
VVAG+ K
Sbjct: 335 VVAGLIK 341
>sp|P25792|CYSP_SCHMA Cathepsin B-like cysteine proteinase precursor (Antigen Sm31)
Length = 340
Score = 251 bits (642), Expect = 8e-67
Identities = 107/184 (58%), Positives = 135/184 (73%), Gaps = 1/184 (0%)
Frame = +2
Query: 5 CGDGCNGGFPSGAWHYWVTDGLVTGGEYGAHLGCQDYAFPKCSHHVIGPYPNCTGE-FPT 181
CG GC GG AW YWV +G+VT H GC+ Y FPKC HH G YP C + + T
Sbjct: 154 CGLGCEGGILGPAWDYWVKEGIVTASSKENHTGCEPYPFPKCEHHTKGKYPPCGSKIYNT 213
Query: 182 PKCKKACQAGYSKTYAEDKQYGKSSYSVDSNQQAIMQEILTNGPVEAAFSVYADFPNYKS 361
P+CK+ CQ Y Y +DK GKSSY+V ++++AI +EI+ GPVEA+F+VY DF NYKS
Sbjct: 214 PRCKQTCQRKYKTPYTQDKHRGKSSYNVKNDEKAIQKEIMKYGPVEASFTVYEDFLNYKS 273
Query: 362 GVYQHVSGGMLGGHAIKILGWGVENNTPYWLVANSWNPTWGDNGYFKILRGSDECGIEDE 541
G+Y+H++G LGGHAI+I+GWGVEN TPYWL+ANSWN WG+NGYF+I+RG DEC IE E
Sbjct: 274 GIYKHITGEALGGHAIRIIGWGVENKTPYWLIANSWNEDWGENGYFRIVRGRDECSIESE 333
Query: 542 VVAG 553
V+AG
Sbjct: 334 VIAG 337
>sp|P43510|CPR6_CAEEL Cathepsin B-like cysteine proteinase 6 precursor (Cysteine
protease-related 6)
Length = 379
Score = 237 bits (604), Expect = 2e-62
Identities = 106/192 (55%), Positives = 135/192 (70%), Gaps = 5/192 (2%)
Frame = +2
Query: 5 CGDGCNGGFPSGAWHYWVTDGLVTGGEYGAHLGCQDYAFPKCSHHV----IGPYPNCTGE 172
CG GCNGG P AW YWV DG+VTG Y A+ GC+ Y FP C HH P P+
Sbjct: 170 CGFGCNGGDPLAAWRYWVKDGIVTGSNYTANNGCKPYPFPPCEHHSKKTHFDPCPHDL-- 227
Query: 173 FPTPKCKKACQAGYS-KTYAEDKQYGKSSYSVDSNQQAIMQEILTNGPVEAAFSVYADFP 349
+PTPKC+K C + Y+ KTY+EDK +G S+Y V + +AI +E++T+GP+E AF VY DF
Sbjct: 228 YPTPKCEKKCVSDYTDKTYSEDKFFGASAYGVKDDVEAIQKELMTHGPLEIAFEVYEDFL 287
Query: 350 NYKSGVYQHVSGGMLGGHAIKILGWGVENNTPYWLVANSWNPTWGDNGYFKILRGSDECG 529
NY GVY H G + GGHA+K++GWG+++ PYW VANSWN WG++G+F+ILRG DECG
Sbjct: 288 NYDGGVYVHTGGKLGGGHAVKLIGWGIDDGIPYWTVANSWNTDWGEDGFFRILRGVDECG 347
Query: 530 IEDEVVAGIPKL 565
IE VV GIPKL
Sbjct: 348 IESGVVGGIPKL 359
>sp|P43509|CPR5_CAEEL Cathepsin B-like cysteine proteinase 5 precursor (Cysteine
protease-related 5)
Length = 344
Score = 228 bits (582), Expect = 7e-60
Identities = 103/191 (53%), Positives = 129/191 (67%), Gaps = 4/191 (2%)
Frame = +2
Query: 5 CGDGCNGGFPSGAWHYWVTDGLVTGGEYGAHLGCQDYAFPKCSHHVIG-PYPNCTGEF-P 178
CG+GC GG+P AW +WV GLVTGG Y GC+ Y+ C V G +P C + P
Sbjct: 150 CGNGCEGGYPIQAWKWWVKHGLVTGGSYETQFGCKPYSIAPCGETVNGVKWPACPEDTEP 209
Query: 179 TPKCKKACQA--GYSKTYAEDKQYGKSSYSVDSNQQAIMQEILTNGPVEAAFSVYADFPN 352
TPKC +C + Y+ Y +DK +G ++Y+V + I EILTNGP+E AF+VY DF
Sbjct: 210 TPKCVDSCTSKNNYATPYLQDKHFGSTAYAVGKKVEQIQTEILTNGPIEVAFTVYEDFYQ 269
Query: 353 YKSGVYQHVSGGMLGGHAIKILGWGVENNTPYWLVANSWNPTWGDNGYFKILRGSDECGI 532
Y +GVY H +G LGGHA+KILGWGV+N TPYWLVANSWN WG+ GYF+I+RG +ECGI
Sbjct: 270 YTTGVYVHTAGASLGGHAVKILGWGVDNGTPYWLVANSWNVAWGEKGYFRIIRGLNECGI 329
Query: 533 EDEVVAGIPKL 565
E VAGIP L
Sbjct: 330 EHSAVAGIPDL 340
>sp|P25793|CYSP2_HAECO Cathepsin B-like cysteine proteinase 2 precursor
Length = 342
Score = 221 bits (564), Expect = 9e-58
Identities = 97/186 (52%), Positives = 129/186 (69%), Gaps = 1/186 (0%)
Frame = +2
Query: 2 RCGDGCNGGFPSGAWHYWVTDGLVTGGEYGAHLGCQDYAFPKCSHHVIGPY-PNCTGEFP 178
+CGDGC GG+P AW Y++ DG+V+GGEY C+ Y C HH Y C G P
Sbjct: 151 QCGDGCEGGWPIEAWKYFIYDGVVSGGEYLTKDVCRPYPIHPCGHHGNDTYYGECRGTAP 210
Query: 179 TPKCKKACQAGYSKTYAEDKQYGKSSYSVDSNQQAIMQEILTNGPVEAAFSVYADFPNYK 358
TP CK+ C+ G K Y DK+YGK +Y V + +AI EIL NGPV A+F+VY DF +YK
Sbjct: 211 TPPCKRKCRPGVRKMYRIDKRYGKDAYIVKQSVKAIQSEILKNGPVVASFAVYEDFRHYK 270
Query: 359 SGVYQHVSGGMLGGHAIKILGWGVENNTPYWLVANSWNPTWGDNGYFKILRGSDECGIED 538
SG+Y+H +G + G HA+K++GWG ENNT +WL+ANSW+ WG+ GYF+I+RGS++CGIE
Sbjct: 271 SGIYKHTAGELRGYHAVKMIGWGNENNTDFWLIANSWHNDWGEKGYFRIVRGSNDCGIEG 330
Query: 539 EVVAGI 556
+ AGI
Sbjct: 331 TIAAGI 336
Database: Non-redundant SwissProt sequences
Posted date: Dec 6, 2005 7:40 AM
Number of letters in database: 68,354,980
Number of sequences in database: 184,735
Database: swissprot.01
Posted date: Dec 6, 2005 8:18 AM
Number of letters in database: 66,202,850
Number of sequences in database: 184,431
Lambda K H
0.318 0.134 0.401
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 81,590,436
Number of Sequences: 369166
Number of extensions: 1922576
Number of successful extensions: 5806
Number of sequences better than 10.0: 10
Number of HSP's better than 10.0 without gapping: 5398
Number of HSP's successfully gapped in prelim test: 0
Number of HSP's that attempted gapping in prelim test: 0
Number of HSP's gapped (non-prelim): 5717
length of database: 68,354,980
effective HSP length: 106
effective length of database: 48,773,070
effective search space used: 4877307000
frameshift window, decay const: 40, 0.1
T: 12
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)