Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= Dr_sW_005_N23
(484 letters)
Database: Non-redundant SwissProt sequences
184,735 sequences; 68,354,980 total letters
Score E
Sequences producing significant alignments: (bits) Value
sp|P18298|METK_RAT S-adenosylmethionine synthetase gamma fo... 218 8e-57
sp|P13444|METL_RAT S-adenosylmethionine synthetase alpha an... 217 1e-56
sp|Q00266|METL_HUMAN S-adenosylmethionine synthetase alpha ... 217 1e-56
sp|P31153|METK_HUMAN S-adenosylmethionine synthetase gamma ... 215 4e-56
sp|P40320|METK_DROME S-adenosylmethionine synthetase (Methi... 203 1e-52
sp|P10659|METK_YEAST S-adenosylmethionine synthetase 1 (Met... 203 2e-52
sp|P19358|METL_YEAST S-adenosylmethionine synthetase 2 (Met... 202 3e-52
sp|P50305|METK_CAEEL Probable S-adenosylmethionine syntheta... 202 4e-52
sp|P50306|METL_CAEEL Probable S-adenosylmethionine syntheta... 199 4e-51
sp|P48466|METK_NEUCR S-adenosylmethionine synthetase (Methi... 196 3e-50
>sp|P18298|METK_RAT S-adenosylmethionine synthetase gamma form (Methionine
adenosyltransferase) (AdoMet synthetase) (MAT-II)
Length = 395
Score = 218 bits (554), Expect = 8e-57
Identities = 106/150 (70%), Positives = 118/150 (78%)
Frame = +3
Query: 6 PSGRFVIGGPQGDAGLTGRKIIVDTYXXXXXXXXXXXXXKDYTKVDRSGAYAARWVAKSL 185
PSGRFVIGGPQGDAGLTGRKIIVDTY KDYTKVDRS AYAARWVAKSL
Sbjct: 246 PSGRFVIGGPQGDAGLTGRKIIVDTYGGWGAHGGGAFSGKDYTKVDRSAAYAARWVAKSL 305
Query: 186 VKAGLCKRILVQLSYAIGIAAPLSIFVDSYGTSSMPDSKLLEIINNNFDLRPGHIEKDLD 365
VK GLC+R+LVQ+SYAIG++ PLSI + YGTS + +LLEI+ NNFDLRPG I +DLD
Sbjct: 306 VKGGLCRRVLVQVSYAIGVSHPLSISIFHYGTSQKSERELLEIVKNNFDLRPGVIVRDLD 365
Query: 366 LRKPIYRRTACYGHFGRSEFTWEQPKLLKY 455
L+KPIY+RTA YGHFGR F WE PK LKY
Sbjct: 366 LKKPIYQRTAAYGHFGRDSFPWEVPKKLKY 395
>sp|P13444|METL_RAT S-adenosylmethionine synthetase alpha and beta forms (Methionine
adenosyltransferase) (AdoMet synthetase) (MAT-I/III)
Length = 397
Score = 217 bits (553), Expect = 1e-56
Identities = 106/151 (70%), Positives = 122/151 (80%), Gaps = 1/151 (0%)
Frame = +3
Query: 6 PSGRFVIGGPQGDAGLTGRKIIVDTYXXXXXXXXXXXXXKDYTKVDRSGAYAARWVAKSL 185
PSGRFVIGGPQGDAG+TGRKIIVDTY KDYTKVDRS AYAARWVAKSL
Sbjct: 247 PSGRFVIGGPQGDAGVTGRKIIVDTYGGWGAHGGGAFSGKDYTKVDRSAAYAARWVAKSL 306
Query: 186 VKAGLCKRILVQLSYAIGIAAPLSIFVDSYGTSSMPD-SKLLEIINNNFDLRPGHIEKDL 362
VKAGLC+R+LVQ+SYAIG+A PLSI + +YGTS + +LLE++N NFDLRPG I +DL
Sbjct: 307 VKAGLCRRVLVQVSYAIGVAEPLSISIFTYGTSKKTERDELLEVVNKNFDLRPGVIVRDL 366
Query: 363 DLRKPIYRRTACYGHFGRSEFTWEQPKLLKY 455
DL+KPIY++TACYGHFGRSEF WE PK L +
Sbjct: 367 DLKKPIYQKTACYGHFGRSEFPWEVPKKLVF 397
>sp|Q00266|METL_HUMAN S-adenosylmethionine synthetase alpha and beta forms (Methionine
adenosyltransferase) (AdoMet synthetase) (MAT-I/III)
Length = 395
Score = 217 bits (553), Expect = 1e-56
Identities = 103/150 (68%), Positives = 122/150 (81%)
Frame = +3
Query: 6 PSGRFVIGGPQGDAGLTGRKIIVDTYXXXXXXXXXXXXXKDYTKVDRSGAYAARWVAKSL 185
PSGRFVIGGPQGDAG+TGRKIIVDTY KDYTKVDRS AYAARWVAKSL
Sbjct: 246 PSGRFVIGGPQGDAGVTGRKIIVDTYGGWGAHGGGAFSGKDYTKVDRSAAYAARWVAKSL 305
Query: 186 VKAGLCKRILVQLSYAIGIAAPLSIFVDSYGTSSMPDSKLLEIINNNFDLRPGHIEKDLD 365
VKAGLC+R+LVQ+SYAIG+A PLSI + +YGTS + +LL++++ NFDLRPG I +DLD
Sbjct: 306 VKAGLCRRVLVQVSYAIGVAEPLSISIFTYGTSQKTERELLDVVHKNFDLRPGVIVRDLD 365
Query: 366 LRKPIYRRTACYGHFGRSEFTWEQPKLLKY 455
L+KPIY++TACYGHFGRSEF WE P+ L +
Sbjct: 366 LKKPIYQKTACYGHFGRSEFPWEVPRKLVF 395
>sp|P31153|METK_HUMAN S-adenosylmethionine synthetase gamma form (Methionine
adenosyltransferase) (AdoMet synthetase) (MAT-II)
Length = 395
Score = 215 bits (548), Expect = 4e-56
Identities = 105/150 (70%), Positives = 117/150 (78%)
Frame = +3
Query: 6 PSGRFVIGGPQGDAGLTGRKIIVDTYXXXXXXXXXXXXXKDYTKVDRSGAYAARWVAKSL 185
PSGRFVIGGPQGDAGLTGRKIIVDTY KDYTKVDRS AYAARWVAKSL
Sbjct: 246 PSGRFVIGGPQGDAGLTGRKIIVDTYGGWGAHGGGAFSGKDYTKVDRSAAYAARWVAKSL 305
Query: 186 VKAGLCKRILVQLSYAIGIAAPLSIFVDSYGTSSMPDSKLLEIINNNFDLRPGHIEKDLD 365
VK GLC+R+LVQ+SYAIG++ PLSI + YGTS + +LLEI+ NFDLRPG I +DLD
Sbjct: 306 VKGGLCRRVLVQVSYAIGVSHPLSISIFHYGTSQKSERELLEIVKKNFDLRPGVIVRDLD 365
Query: 366 LRKPIYRRTACYGHFGRSEFTWEQPKLLKY 455
L+KPIY+RTA YGHFGR F WE PK LKY
Sbjct: 366 LKKPIYQRTAAYGHFGRDSFPWEVPKKLKY 395
>sp|P40320|METK_DROME S-adenosylmethionine synthetase (Methionine adenosyltransferase)
(AdoMet synthetase)
Length = 408
Score = 203 bits (517), Expect = 1e-52
Identities = 102/150 (68%), Positives = 115/150 (76%)
Frame = +3
Query: 3 NPSGRFVIGGPQGDAGLTGRKIIVDTYXXXXXXXXXXXXXKDYTKVDRSGAYAARWVAKS 182
NP G FVIGGP GDAGLTGRKIIVDTY KD+TKVDRS AYAARWVAKS
Sbjct: 256 NPCGLFVIGGPMGDAGLTGRKIIVDTYGGWGAHGGGAFSGKDFTKVDRSAAYAARWVAKS 315
Query: 183 LVKAGLCKRILVQLSYAIGIAAPLSIFVDSYGTSSMPDSKLLEIINNNFDLRPGHIEKDL 362
LVKAGLCKR LVQ+SYAIG+A PLSI V YGTS +LL+II NFDLRPG I KDL
Sbjct: 316 LVKAGLCKRCLVQVSYAIGLAEPLSITVFDYGTSHKSQKELLDIIRRNFDLRPGKIVKDL 375
Query: 363 DLRKPIYRRTACYGHFGRSEFTWEQPKLLK 452
+LR+PIY+RT+ YGHFGR+ F+WE+ K L+
Sbjct: 376 NLRQPIYQRTSTYGHFGRAGFSWEEAKPLE 405
>sp|P10659|METK_YEAST S-adenosylmethionine synthetase 1 (Methionine adenosyltransferase
1) (AdoMet synthetase 1)
Length = 382
Score = 203 bits (516), Expect = 2e-52
Identities = 98/150 (65%), Positives = 115/150 (76%)
Frame = +3
Query: 6 PSGRFVIGGPQGDAGLTGRKIIVDTYXXXXXXXXXXXXXKDYTKVDRSGAYAARWVAKSL 185
PSGRFVIGGPQGDAGLTGRKIIVD Y KDY+KVDRS AYAARWVAKSL
Sbjct: 233 PSGRFVIGGPQGDAGLTGRKIIVDAYGGASSVGGGAFSGKDYSKVDRSAAYAARWVAKSL 292
Query: 186 VKAGLCKRILVQLSYAIGIAAPLSIFVDSYGTSSMPDSKLLEIINNNFDLRPGHIEKDLD 365
V AGLCKR+ VQ SYAIGIA PLS+ VD+YGT++ D ++++II+ NFDLRPG + K+LD
Sbjct: 293 VAAGLCKRVQVQFSYAIGIAEPLSLHVDTYGTATKSDEEIIDIISKNFDLRPGVLVKELD 352
Query: 366 LRKPIYRRTACYGHFGRSEFTWEQPKLLKY 455
L +PIY TA YGHF E+ WE+PK LK+
Sbjct: 353 LARPIYLPTASYGHFTNQEYPWEKPKTLKF 382
>sp|P19358|METL_YEAST S-adenosylmethionine synthetase 2 (Methionine adenosyltransferase
2) (AdoMet synthetase 2)
Length = 384
Score = 202 bits (515), Expect = 3e-52
Identities = 98/150 (65%), Positives = 115/150 (76%)
Frame = +3
Query: 6 PSGRFVIGGPQGDAGLTGRKIIVDTYXXXXXXXXXXXXXKDYTKVDRSGAYAARWVAKSL 185
PSGRFVIGGPQGDAGLTGRKIIVD Y KDY+KVDRS AYAARWVAKSL
Sbjct: 235 PSGRFVIGGPQGDAGLTGRKIIVDAYGGASSVGGGAFSGKDYSKVDRSAAYAARWVAKSL 294
Query: 186 VKAGLCKRILVQLSYAIGIAAPLSIFVDSYGTSSMPDSKLLEIINNNFDLRPGHIEKDLD 365
V AGLCKR+ VQ SYAIGIA PLS+ VD+YGT++ D +++EII NFDLRPG + K+LD
Sbjct: 295 VAAGLCKRVQVQFSYAIGIAEPLSLHVDTYGTATKSDDEIIEIIKKNFDLRPGVLVKELD 354
Query: 366 LRKPIYRRTACYGHFGRSEFTWEQPKLLKY 455
L +PIY TA YGHF E++WE+PK L++
Sbjct: 355 LARPIYLPTASYGHFTNQEYSWEKPKKLEF 384
>sp|P50305|METK_CAEEL Probable S-adenosylmethionine synthetase C06E7.1 (Methionine
adenosyltransferase) (AdoMet synthetase)
Length = 404
Score = 202 bits (513), Expect = 4e-52
Identities = 99/150 (66%), Positives = 117/150 (78%)
Frame = +3
Query: 3 NPSGRFVIGGPQGDAGLTGRKIIVDTYXXXXXXXXXXXXXKDYTKVDRSGAYAARWVAKS 182
NP G F+IGGP GDAGLTGRKIIVDTY KD TKVDRS AYAARWVAKS
Sbjct: 233 NPCGSFIIGGPMGDAGLTGRKIIVDTYGGWGAHGGGAFSGKDPTKVDRSAAYAARWVAKS 292
Query: 183 LVKAGLCKRILVQLSYAIGIAAPLSIFVDSYGTSSMPDSKLLEIINNNFDLRPGHIEKDL 362
LVK+GLC+R LVQ+SYAIG+A PLS+ V S+GTS++ + +LL+I+N+NFDLRPG I KDL
Sbjct: 293 LVKSGLCRRCLVQVSYAIGVAKPLSVMVFSFGTSALNEGELLKIVNDNFDLRPGMIIKDL 352
Query: 363 DLRKPIYRRTACYGHFGRSEFTWEQPKLLK 452
DL+KPIY TA GHFG +EF WEQP+ L+
Sbjct: 353 DLKKPIYEPTAENGHFGHNEFPWEQPRHLQ 382
>sp|P50306|METL_CAEEL Probable S-adenosylmethionine synthetase C06E7.3 (Methionine
adenosyltransferase) (AdoMet synthetase)
Length = 404
Score = 199 bits (505), Expect = 4e-51
Identities = 98/150 (65%), Positives = 114/150 (76%)
Frame = +3
Query: 3 NPSGRFVIGGPQGDAGLTGRKIIVDTYXXXXXXXXXXXXXKDYTKVDRSGAYAARWVAKS 182
NP G F+IGGP GDAGLTGRKIIVDTY KD TKVDRS AYAARWVAKS
Sbjct: 233 NPCGSFIIGGPMGDAGLTGRKIIVDTYGGWGAHGGGAFSGKDPTKVDRSAAYAARWVAKS 292
Query: 183 LVKAGLCKRILVQLSYAIGIAAPLSIFVDSYGTSSMPDSKLLEIINNNFDLRPGHIEKDL 362
LVKAGLC+R LVQ+SYAIG+A PLS+ V S+GTS++ + LL I+N+NFDLRPG I K+L
Sbjct: 293 LVKAGLCRRCLVQVSYAIGVAKPLSVMVFSFGTSALSEEDLLTIVNDNFDLRPGKIIKNL 352
Query: 363 DLRKPIYRRTACYGHFGRSEFTWEQPKLLK 452
DL++PIY TA GHFG + F WEQP+ LK
Sbjct: 353 DLKRPIYEPTAENGHFGHNNFPWEQPRNLK 382
>sp|P48466|METK_NEUCR S-adenosylmethionine synthetase (Methionine adenosyltransferase)
(AdoMet synthetase)
Length = 395
Score = 196 bits (497), Expect = 3e-50
Identities = 98/151 (64%), Positives = 115/151 (76%), Gaps = 1/151 (0%)
Frame = +3
Query: 6 PSGRFVIGGPQGDAGLTGRKIIVDTYXXXXXXXXXXXXXKDYTKVDRSGAYAARWVAKSL 185
PSG FVIGGPQGDAGLTGRKIIVDTY KD++KVDRS AY RW+AKSL
Sbjct: 245 PSGLFVIGGPQGDAGLTGRKIIVDTYGGWGAHGGGAFSGKDFSKVDRSAAYVGRWIAKSL 304
Query: 186 VKAGLCKRILVQLSYAIGIAAPLSIFVDSYGTSSMPDSKLLEIINNNFDLRPGHIEKDLD 365
V AGL +R LVQLSYAIG+A PLSI+VD+YGTS +L++II NNFDLRPG I K+LD
Sbjct: 305 VAAGLARRALVQLSYAIGVAEPLSIYVDTYGTSDKTSEELVQIIRNNFDLRPGVIVKELD 364
Query: 366 LRKPIYRRTACYGHFGRSE-FTWEQPKLLKY 455
L KPIY +TA GHFG ++ F+WE+PK LK+
Sbjct: 365 LAKPIYLQTAKNGHFGTNQSFSWEKPKALKF 395
Database: Non-redundant SwissProt sequences
Posted date: Dec 6, 2005 7:40 AM
Number of letters in database: 68,354,980
Number of sequences in database: 184,735
Database: swissprot.01
Posted date: Dec 6, 2005 8:18 AM
Number of letters in database: 66,202,850
Number of sequences in database: 184,431
Lambda K H
0.318 0.134 0.401
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 60,314,718
Number of Sequences: 369166
Number of extensions: 1229448
Number of successful extensions: 3102
Number of sequences better than 10.0: 10
Number of HSP's better than 10.0 without gapping: 2928
Number of HSP's successfully gapped in prelim test: 0
Number of HSP's that attempted gapping in prelim test: 0
Number of HSP's gapped (non-prelim): 3050
length of database: 68,354,980
effective HSP length: 102
effective length of database: 49,512,010
effective search space used: 2871696580
frameshift window, decay const: 40, 0.1
T: 12
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)