Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= Dr_sW_005_M13
(843 letters)
Database: Non-redundant SwissProt sequences
184,735 sequences; 68,354,980 total letters
Score E
Sequences producing significant alignments: (bits) Value
sp|Q24940|CATLP_FASHE Cathepsin L-like proteinase precursor 162 8e-40
sp|O60911|CATL2_HUMAN Cathepsin L2 precursor (Cathepsin V) ... 149 9e-36
sp|P07711|CATL_HUMAN Cathepsin L precursor (Major excreted ... 139 7e-33
sp|P06797|CATL_MOUSE Cathepsin L precursor (Major excreted ... 139 1e-32
sp|Q8HY82|CATS_SAIBB Cathepsin S precursor 137 3e-32
sp|Q95029|CATL_DROME Cathepsin L precursor (Cysteine protei... 137 4e-32
sp|P07154|CATL_RAT Cathepsin L precursor (Major excreted pr... 137 5e-32
sp|Q9R014|CATJ_MOUSE Cathepsin J precursor (Cathepsin P) (C... 136 8e-32
sp|Q9GL24|CATL_CANFA Cathepsin L precursor [Contains: Cathe... 135 1e-31
sp|Q26636|CATL_SARPE Cathepsin L precursor [Contains: Cathe... 135 2e-31
>sp|Q24940|CATLP_FASHE Cathepsin L-like proteinase precursor
Length = 326
Score = 162 bits (411), Expect = 8e-40
Identities = 84/231 (36%), Positives = 126/231 (54%), Gaps = 6/231 (2%)
Frame = +2
Query: 86 WEDYKTIFNKKYSDETDLIRRNIWEENMEFIKQHNLQFDLGKTKFSVGLNEFSDMNQIEF 265
W +K ++NK+Y+ D RRNIWE+N++ I++HNL+ DLG +++GLN+F+DM EF
Sbjct: 21 WHQWKRMYNKEYNGADDQHRRNIWEKNVKHIQEHNLRHDLGLVTYTLGLNQFTDMTFEEF 80
Query: 266 QSNILSVXXXXXXXXXXXXXXXXXXLSRNDFITT------PNNIKLPDSWDWREKGAVSP 427
++ L+ +SR I + NN +PD DWRE G V+
Sbjct: 81 KAKYLT------------------EMSRASDILSHGVPYEANNRAVPDKIDWRESGYVTE 122
Query: 428 VGNQRNNSCGYAFAAAGALEGQNFNLTKTLEILSKQQIIDCSVYYGNSGCYGGILSKAYA 607
V +Q N +AF+ G +EGQ +T S+QQ++DCS +GN+GC GG++ AY
Sbjct: 123 VKDQGNCGSCWAFSTTGTMEGQYMKNERTSISFSEQQLVDCSGPWGNNGCSGGLMENAYQ 182
Query: 608 YLADYGSELDEDYPFVKCNSNCKYDKSLATVKPYGFKYVSRGKEADLMNAV 760
YL +G E + YP+ C+Y+K L K G+ V G E +L N V
Sbjct: 183 YLKQFGLETESSYPYTAVEGQCRYNKQLGVAKVTGYYTVHSGSEVELKNLV 233
>sp|O60911|CATL2_HUMAN Cathepsin L2 precursor (Cathepsin V) (Cathepsin U)
Length = 334
Score = 149 bits (376), Expect = 9e-36
Identities = 83/250 (33%), Positives = 128/250 (51%), Gaps = 1/250 (0%)
Frame = +2
Query: 29 VKQSLRRIDSNVNSQLNKDWEDYKTIFNKKYSDETDLIRRNIWEENMEFIKQHNLQFDLG 208
+ ++ + D N++++ W +K + Y + RR +WE+NM+ I+ HN ++ G
Sbjct: 14 IASAVPKFDQNLDTK----WYQWKATHRRLYGANEEGWRRAVWEKNMKMIELHNGEYSQG 69
Query: 209 KTKFSVGLNEFSDMNQIEFQSNILSVXXXXXXXXXXXXXXXXXXLSRNDFITTPNNIKLP 388
K F++ +N F DM EF+ + + P + LP
Sbjct: 70 KHGFTMAMNAFGDMTNEEFRQMM--------------GCFRNQKFRKGKVFREPLFLDLP 115
Query: 389 DSWDWREKGAVSPVGNQRNNSCGYAFAAAGALEGQNFNLTKTLEILSKQQIIDCSVYYGN 568
S DWR+KG V+PV NQ+ +AF+A GALEGQ F T L LS+Q ++DCS GN
Sbjct: 116 KSVDWRKKGYVTPVKNQKQCGSCWAFSATGALEGQMFRKTGKLVSLSEQNLVDCSRPQGN 175
Query: 569 SGCYGGILSKAYAYLADYGS-ELDEDYPFVKCNSNCKYDKSLATVKPYGFKYVSRGKEAD 745
GC GG +++A+ Y+ + G + +E YP+V + CKY + GF V+ GKE
Sbjct: 176 QGCNGGFMARAFQYVKENGGLDSEESYPYVAVDEICKYRPENSVANDTGFTVVAPGKEKA 235
Query: 746 LMNAVYNIGP 775
LM AV +GP
Sbjct: 236 LMKAVATVGP 245
Score = 30.4 bits (67), Expect = 6.4
Identities = 13/21 (61%), Positives = 17/21 (80%)
Frame = +3
Query: 774 PISAAIDASPTSFKQYKTGIY 836
PIS A+DA +SF+ YK+GIY
Sbjct: 245 PISVAMDAGHSSFQFYKSGIY 265
>sp|P07711|CATL_HUMAN Cathepsin L precursor (Major excreted protein) (MEP) [Contains:
Cathepsin L heavy chain; Cathepsin L light chain]
Length = 333
Score = 139 bits (351), Expect = 7e-33
Identities = 80/235 (34%), Positives = 118/235 (50%), Gaps = 1/235 (0%)
Frame = +2
Query: 74 LNKDWEDYKTIFNKKYSDETDLIRRNIWEENMEFIKQHNLQFDLGKTKFSVGLNEFSDMN 253
L W +K + N+ Y + RR +WE+NM+ I+ HN ++ GK F++ +N F DM
Sbjct: 25 LEAQWTKWKAMHNRLYGMNEEGWRRAVWEKNMKMIELHNQEYREGKHSFTMAMNAFGDMT 84
Query: 254 QIEFQSNILSVXXXXXXXXXXXXXXXXXXLSRNDFITTPNNIKLPDSWDWREKGAVSPVG 433
EF+ + + P + P S DWREKG V+PV
Sbjct: 85 SEEFRQVMNGFQNRKPR--------------KGKVFQEPLFYEAPRSVDWREKGYVTPVK 130
Query: 434 NQRNNSCGYAFAAAGALEGQNFNLTKTLEILSKQQIIDCSVYYGNSGCYGGILSKAYAYL 613
NQ +AF+A GALEGQ F T L LS+Q ++DCS GN GC GG++ A+ Y+
Sbjct: 131 NQGQCGSCWAFSATGALEGQMFRKTGRLISLSEQNLVDCSGPQGNEGCNGGLMDYAFQYV 190
Query: 614 ADYGS-ELDEDYPFVKCNSNCKYDKSLATVKPYGFKYVSRGKEADLMNAVYNIGP 775
D G + +E YP+ +CKY+ + GF + + ++A LM AV +GP
Sbjct: 191 QDNGGLDSEESYPYEATEESCKYNPKYSVANDTGFVDIPKQEKA-LMKAVATVGP 244
>sp|P06797|CATL_MOUSE Cathepsin L precursor (Major excreted protein) (MEP) (p39 cysteine
proteinase) [Contains: Cathepsin L heavy chain;
Cathepsin L light chain]
Length = 334
Score = 139 bits (350), Expect = 1e-32
Identities = 79/232 (34%), Positives = 118/232 (50%), Gaps = 1/232 (0%)
Frame = +2
Query: 83 DWEDYKTIFNKKYSDETDLIRRNIWEENMEFIKQHNLQFDLGKTKFSVGLNEFSDMNQIE 262
+W +K+ + Y + RR IWE+NM I+ HN ++ G+ FS+ +N F DM E
Sbjct: 28 EWHQWKSTHRRLYGTNEEEWRRAIWEKNMRMIQLHNGEYSNGQHGFSMEMNAFGDMTNEE 87
Query: 263 FQSNILSVXXXXXXXXXXXXXXXXXXLSRNDFITTPNNIKLPDSWDWREKGAVSPVGNQR 442
F+ + + P +K+P S DWREKG V+PV NQ
Sbjct: 88 FRQVVNGYRHQKH--------------KKGRLFQEPLMLKIPKSVDWREKGCVTPVKNQG 133
Query: 443 NNSCGYAFAAAGALEGQNFNLTKTLEILSKQQIIDCSVYYGNSGCYGGILSKAYAYLADY 622
+AF+A+G LEGQ F T L LS+Q ++DCS GN GC GG++ A+ Y+ +
Sbjct: 134 QCGSCWAFSASGCLEGQMFLKTGKLISLSEQNLVDCSHAQGNQGCNGGLMDFAFQYIKEN 193
Query: 623 GS-ELDEDYPFVKCNSNCKYDKSLATVKPYGFKYVSRGKEADLMNAVYNIGP 775
G + +E YP+ + +CKY A GF + + ++A LM AV +GP
Sbjct: 194 GGLDSEESYPYEAKDGSCKYRAEFAVANDTGFVDIPQQEKA-LMKAVATVGP 244
>sp|Q8HY82|CATS_SAIBB Cathepsin S precursor
Length = 330
Score = 137 bits (346), Expect = 3e-32
Identities = 86/258 (33%), Positives = 128/258 (49%), Gaps = 8/258 (3%)
Frame = +2
Query: 56 SNVNSQLNKD------WEDYKTIFNKKYSDETD-LIRRNIWEENMEFIKQHNLQFDLGKT 214
S+ +QL+KD W +K + K+Y ++ + +RR IWE+N++F+ HNL+ +G
Sbjct: 12 SSAVTQLHKDPTLDHHWNLWKKTYGKQYKEKNEEAVRRLIWEKNLKFVMLHNLEHSMGMH 71
Query: 215 KFSVGLNEFSDMNQIEFQSNILSVXXXXXXXXXXXXXXXXXXLSRNDFITTPNNIKLPDS 394
+ +G+N DM E S + S+ RN + N LPDS
Sbjct: 72 SYDLGMNHLGDMTSEEVMSLMSSLRVPNQW-------------QRNITYKSNPNQMLPDS 118
Query: 395 WDWREKGAVSPVGNQRNNSCGYAFAAAGALEGQNFNLTKTLEILSKQQIIDCSVYYGNSG 574
DWREKG V+ V Q + +AF+A GALE Q T L LS Q ++DCS YGN G
Sbjct: 119 VDWREKGCVTEVKYQGSCGACWAFSAVGALEAQLKLKTGKLVSLSAQNLVDCSEKYGNKG 178
Query: 575 CYGGILSKAYAYLAD-YGSELDEDYPFVKCNSNCKYDKSLATVKPYGFKYVSRGKEADLM 751
C GG +++A+ Y+ D G + + YP+ + C+YD + + G+E L
Sbjct: 179 CNGGFMTEAFQYIIDNKGIDSEASYPYKATDQKCQYDSKYRAATCSKYTELPYGREDVLK 238
Query: 752 NAVYNIGPNICSDRCKSH 805
AV N GP +C SH
Sbjct: 239 EAVANKGP-VCVGVDASH 255
>sp|Q95029|CATL_DROME Cathepsin L precursor (Cysteine proteinase 1) [Contains: Cathepsin
L heavy chain; Cathepsin L light chain]
Length = 341
Score = 137 bits (345), Expect = 4e-32
Identities = 76/234 (32%), Positives = 122/234 (52%), Gaps = 2/234 (0%)
Frame = +2
Query: 80 KDWEDYKTIFNKKYSDETD-LIRRNIWEENMEFIKQHNLQFDLGKTKFSVGLNEFSDMNQ 256
++W +K K Y DET+ R I+ EN I +HN +F GK F + +N+++D+
Sbjct: 27 EEWHTFKLEHRKNYQDETEERFRLKIFNENKHKIAKHNQRFAEGKVSFKLAVNKYADLLH 86
Query: 257 IEFQSNILSVXXXXXXXXXXXXXXXXXXLSRNDFITTPNNIKLPDSWDWREKGAVSPVGN 436
EF+ + FI+ P ++ LP S DWR KGAV+ V +
Sbjct: 87 HEFRQ----LMNGFNYTLHKQLRAADESFKGVTFIS-PAHVTLPKSVDWRTKGAVTAVKD 141
Query: 437 QRNNSCGYAFAAAGALEGQNFNLTKTLEILSKQQIIDCSVYYGNSGCYGGILSKAYAYLA 616
Q + +AF++ GALEGQ+F + L LS+Q ++DCS YGN+GC GG++ A+ Y+
Sbjct: 142 QGHCGSCWAFSSTGALEGQHFRKSGVLVSLSEQNLVDCSTKYGNNGCNGGLMDNAFRYIK 201
Query: 617 DYGS-ELDEDYPFVKCNSNCKYDKSLATVKPYGFKYVSRGKEADLMNAVYNIGP 775
D G + ++ YP+ + +C ++K GF + +G E + AV +GP
Sbjct: 202 DNGGIDTEKSYPYEAIDDSCHFNKGTVGATDRGFTDIPQGDEKKMAEAVATVGP 255
Score = 30.0 bits (66), Expect = 8.3
Identities = 12/23 (52%), Positives = 17/23 (73%)
Frame = +3
Query: 774 PISAAIDASPTSFKQYKTGIYDD 842
P+S AIDAS SF+ Y G+Y++
Sbjct: 255 PVSVAIDASHESFQFYSEGVYNE 277
>sp|P07154|CATL_RAT Cathepsin L precursor (Major excreted protein) (MEP) (Cyclic
protein 2) (CP-2) [Contains: Cathepsin L heavy chain;
Cathepsin L light chain]
Length = 334
Score = 137 bits (344), Expect = 5e-32
Identities = 77/234 (32%), Positives = 118/234 (50%), Gaps = 1/234 (0%)
Frame = +2
Query: 77 NKDWEDYKTIFNKKYSDETDLIRRNIWEENMEFIKQHNLQFDLGKTKFSVGLNEFSDMNQ 256
N W +K+ + Y + RR +WE+NM I+ HN ++ GK F++ +N F DM
Sbjct: 26 NAQWHQWKSTHRRLYGTNEEEWRRAVWEKNMRMIQLHNGEYSNGKHGFTMEMNAFGDMTN 85
Query: 257 IEFQSNILSVXXXXXXXXXXXXXXXXXXLSRNDFITTPNNIKLPDSWDWREKGAVSPVGN 436
EF+ + + P +++P + DWREKG V+PV N
Sbjct: 86 EEFRQIVNGYRHQKH--------------KKGRLFQEPLMLQIPKTVDWREKGCVTPVKN 131
Query: 437 QRNNSCGYAFAAAGALEGQNFNLTKTLEILSKQQIIDCSVYYGNSGCYGGILSKAYAYLA 616
Q +AF+A+G LEGQ F T L LS+Q ++DCS GN GC GG++ A+ Y+
Sbjct: 132 QGQCGSCWAFSASGCLEGQMFLKTGKLISLSEQNLVDCSHDQGNQGCNGGLMDFAFQYIK 191
Query: 617 DYGS-ELDEDYPFVKCNSNCKYDKSLATVKPYGFKYVSRGKEADLMNAVYNIGP 775
+ G + +E YP+ + +CKY A GF + + ++A LM AV +GP
Sbjct: 192 ENGGLDSEESYPYEAKDGSCKYRAEYAVANDTGFVDIPQQEKA-LMKAVATVGP 244
>sp|Q9R014|CATJ_MOUSE Cathepsin J precursor (Cathepsin P) (Catlrp-p)
Length = 333
Score = 136 bits (342), Expect = 8e-32
Identities = 87/241 (36%), Positives = 125/241 (51%), Gaps = 6/241 (2%)
Frame = +2
Query: 71 QLNKDWEDYKTIFNKKYSDETDLIRRNIWEENMEFIKQHNLQFDLGKTKFSVGLNEFSDM 250
+L+ +W+D+KT + K YS E + +RR +WEENM IK HN + LGK F++ +N+F D
Sbjct: 24 KLDAEWKDWKTKYAKSYSPE-EALRRAVWEENMRMIKLHNKENSLGKNNFTMKMNKFGDQ 82
Query: 251 NQIEFQSNILSVXXXXXXXXXXXXXXXXXXLSRNDFITTPN-----NIKLPDSWDWREKG 415
EF+ +I ++ +T P+ +I LPD DWRE+G
Sbjct: 83 TSEEFRKSIDNIPIPAA-------------------MTDPHAQNHVSIGLPDYKDWREEG 123
Query: 416 AVSPVGNQRNNSCGYAFAAAGALEGQNFNLTKTLEILSKQQIIDCSVYYGNSGCYGGILS 595
V+PV NQ +AFAAAGA+EGQ F T L LS Q ++DCS GN GC G
Sbjct: 124 YVTPVRNQGKCGSCWAFAAAGAIEGQMFWKTGNLTPLSVQNLLDCSKTVGNKGCQSGTAH 183
Query: 596 KAYAY-LADYGSELDEDYPFVKCNSNCKYDKSLATVKPYGFKYVSRGKEADLMNAVYNIG 772
+A+ Y L + G E + YP+ + C+Y A+ + + E L AV +IG
Sbjct: 184 QAFEYVLKNKGLEAEATYPYEGKDGPCRYRSENASANITDYVNLP-PNELYLWVAVASIG 242
Query: 773 P 775
P
Sbjct: 243 P 243
Score = 30.8 bits (68), Expect = 4.9
Identities = 14/21 (66%), Positives = 16/21 (76%)
Frame = +3
Query: 774 PISAAIDASPTSFKQYKTGIY 836
P+SAAIDAS SF+ Y GIY
Sbjct: 243 PVSAAIDASHDSFRFYNGGIY 263
>sp|Q9GL24|CATL_CANFA Cathepsin L precursor [Contains: Cathepsin L heavy chain; Cathepsin
L light chain]
Length = 333
Score = 135 bits (341), Expect = 1e-31
Identities = 79/239 (33%), Positives = 117/239 (48%), Gaps = 2/239 (0%)
Frame = +2
Query: 65 NSQLNKDWEDYKTIFNKKYSDETDLIRRNIWEENMEFIKQHNLQFDLGKTKFSVGLNEFS 244
+ LN W +K + Y + RR +WE+NM+ I+ HN ++ GK F++ +N F
Sbjct: 22 DQSLNAQWYQWKATHRRLYGMNEEGWRRAVWEKNMKMIELHNREYSQGKHGFTMAMNAFG 81
Query: 245 DMNQIEFQSNILSVXXXXXXXXXXXXXXXXXXLSRNDFITTPNNIKLPDSWDWREKGAVS 424
DM EF+ + + P ++P S DWREKG V+
Sbjct: 82 DMTNEEFRQVMNGFQNQKH--------------KKGKMFQEPLFAEIPKSVDWREKGYVT 127
Query: 425 PVGNQRNNSCGYAFAAAGALEGQNFNLTKTLEILSKQQIIDCSVYYGNSGCYGGILSKAY 604
PV NQ +AF+A GALEGQ F T L LS+Q ++DCS GN GC GG++ A+
Sbjct: 128 PVKNQGQCGSCWAFSATGALEGQMFRKTGKLVSLSEQNLVDCSRAQGNEGCNGGLMDNAF 187
Query: 605 AYLADYGS-ELDEDYPFV-KCNSNCKYDKSLATVKPYGFKYVSRGKEADLMNAVYNIGP 775
Y+ D G + +E YP++ + C Y + GF + + +E LM AV +GP
Sbjct: 188 RYVKDNGGLDSEESYPYLGRDTETCNYKPECSAANDTGFVDLPQ-REKALMKAVATLGP 245
Score = 32.0 bits (71), Expect = 2.2
Identities = 15/23 (65%), Positives = 17/23 (73%)
Frame = +3
Query: 774 PISAAIDASPTSFKQYKTGIYDD 842
PIS AIDA SF+ YK+GIY D
Sbjct: 245 PISVAIDAGHQSFQFYKSGIYFD 267
>sp|Q26636|CATL_SARPE Cathepsin L precursor [Contains: Cathepsin L heavy chain; Cathepsin
L light chain]
Length = 339
Score = 135 bits (339), Expect = 2e-31
Identities = 76/236 (32%), Positives = 122/236 (51%), Gaps = 2/236 (0%)
Frame = +2
Query: 74 LNKDWEDYKTIFNKKYSDETD-LIRRNIWEENMEFIKQHNLQFDLGKTKFSVGLNEFSDM 250
+ ++W YK K Y++E + R I+ EN I +HN F GK + +GLN+++DM
Sbjct: 24 IKEEWHTYKLQHRKNYANEVEERFRMKIFNENRHKIAKHNQLFAQGKVSYKLGLNKYADM 83
Query: 251 NQIEFQSNILSVXXXXXXXXXXXXXXXXXXLSRNDFITTPNNIKLPDSWDWREKGAVSPV 430
EF+ + L +I P ++ +P S DWRE GAV+ V
Sbjct: 84 LHHEFKETM-----NGYNHTLRQLMRERTGLVGATYI-PPAHVTVPKSVDWREHGAVTGV 137
Query: 431 GNQRNNSCGYAFAAAGALEGQNFNLTKTLEILSKQQIIDCSVYYGNSGCYGGILSKAYAY 610
+Q + +AF++ GALEGQ+F L LS+Q ++DCS YGN+GC GG++ A+ Y
Sbjct: 138 KDQGHCGSCWAFSSTGALEGQHFRKAGVLVSLSEQNLVDCSTKYGNNGCNGGLMDNAFRY 197
Query: 611 LADYGS-ELDEDYPFVKCNSNCKYDKSLATVKPYGFKYVSRGKEADLMNAVYNIGP 775
+ D G + ++ YP+ + +C ++K+ GF + G E + AV +GP
Sbjct: 198 IKDNGGIDTEKSYPYEGIDDSCHFNKATIGATDTGFVDIPEGDEEKMKKAVATMGP 253
Score = 30.4 bits (67), Expect = 6.4
Identities = 12/23 (52%), Positives = 17/23 (73%)
Frame = +3
Query: 774 PISAAIDASPTSFKQYKTGIYDD 842
P+S AIDAS SF+ Y G+Y++
Sbjct: 253 PVSVAIDASHESFQLYSEGVYNE 275
Database: Non-redundant SwissProt sequences
Posted date: Dec 6, 2005 7:40 AM
Number of letters in database: 68,354,980
Number of sequences in database: 184,735
Database: swissprot.01
Posted date: Dec 6, 2005 8:18 AM
Number of letters in database: 66,202,850
Number of sequences in database: 184,431
Lambda K H
0.318 0.134 0.401
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 82,187,540
Number of Sequences: 369166
Number of extensions: 1462418
Number of successful extensions: 4617
Number of sequences better than 10.0: 10
Number of HSP's better than 10.0 without gapping: 4176
Number of HSP's successfully gapped in prelim test: 0
Number of HSP's that attempted gapping in prelim test: 0
Number of HSP's gapped (non-prelim): 4417
length of database: 68,354,980
effective HSP length: 109
effective length of database: 48,218,865
effective search space used: 8245425915
frameshift window, decay const: 40, 0.1
T: 12
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)