Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= Dr_sW_005_K03
(705 letters)
Database: Non-redundant SwissProt sequences
184,735 sequences; 68,354,980 total letters
Score E
Sequences producing significant alignments: (bits) Value
sp|P42687|SPK1_DUGTI Tyrosine-protein kinase SPK-1 339 4e-93
sp|Q07014|LYN_RAT Tyrosine-protein kinase Lyn 192 6e-49
sp|P25911|LYN_MOUSE Tyrosine-protein kinase Lyn 192 7e-49
sp|P07948|LYN_HUMAN Tyrosine-protein kinase Lyn 191 2e-48
sp|Q95KR7|LCK_SAISC Proto-oncogene tyrosine-protein kinase ... 191 2e-48
sp|P50545|HCK_RAT Tyrosine-protein kinase HCK (p56-HCK) (He... 190 4e-48
sp|P08103|HCK_MOUSE Tyrosine-protein kinase HCK (p56-HCK/p5... 190 4e-48
sp|P08631|HCK_HUMAN Tyrosine-protein kinase HCK (p59-HCK/p6... 188 1e-47
sp|P42683|LCK_CHICK Proto-oncogene tyrosine-protein kinase ... 188 1e-47
sp|P00526|SRC_RSVP Tyrosine-protein kinase transforming pro... 187 2e-47
>sp|P42687|SPK1_DUGTI Tyrosine-protein kinase SPK-1
Length = 497
Score = 339 bits (870), Expect = 4e-93
Identities = 164/210 (78%), Positives = 183/210 (87%)
Frame = +3
Query: 3 MPMIIIVEFMKNGSLKEYLKSEDGKQIILSQMIHMMAEISEGMAYLEGEKVVHRDLRADN 182
MPM+IIVE+MKNGSLKEYLK+ DGK+ L+QM+HMMAEISEGMAYLE EKVVHRDLRADN
Sbjct: 288 MPMLIIVEYMKNGSLKEYLKTPDGKKTNLNQMVHMMAEISEGMAYLESEKVVHRDLRADN 347
Query: 183 ILVADDLTVKVADFGLTELTEGNNDSQEKKNLRFPYKWTAPEAAKTKIFTSKSDVWSFGI 362
ILVA+DLT KVADFGLTELT+G+ QEKK LRFPYKWTAPEAAK+K+FTSKSDVWS+GI
Sbjct: 348 ILVANDLTRKVADFGLTELTDGSLGDQEKKTLRFPYKWTAPEAAKSKVFTSKSDVWSYGI 407
Query: 363 VMYEILTWASPPYPDTPAKEVIDKVSSGYRMPNPEKFIPGARCPDEIYKIMLNCWNVLPE 542
VM+EILTWAS PYPD PAKEVI+KVS GYRMPNPEKFI G CPDEIYKIM+ CW+ PE
Sbjct: 408 VMFEILTWASSPYPDIPAKEVIEKVSKGYRMPNPEKFITGVCCPDEIYKIMIWCWDANPE 467
Query: 543 ERPTFASLQEQMDTLIVDNTGSGTYYSQSK 632
+RPTF LQE+MD LIVD + YYS SK
Sbjct: 468 KRPTFLVLQEKMDLLIVDTLTNNAYYSHSK 497
>sp|Q07014|LYN_RAT Tyrosine-protein kinase Lyn
Length = 512
Score = 192 bits (489), Expect = 6e-49
Identities = 95/200 (47%), Positives = 129/200 (64%)
Frame = +3
Query: 6 PMIIIVEFMKNGSLKEYLKSEDGKQIILSQMIHMMAEISEGMAYLEGEKVVHRDLRADNI 185
P+ II EFM GSL ++LKS++G +++L ++I A+I+EGMAY+E + +HRDLRA N+
Sbjct: 314 PIYIITEFMAKGSLLDFLKSDEGSKVLLPKLIDFSAQIAEGMAYIERKNYIHRDLRAANV 373
Query: 186 LVADDLTVKVADFGLTELTEGNNDSQEKKNLRFPYKWTAPEAAKTKIFTSKSDVWSFGIV 365
LV++ L K+ADFGL + E +N+ ++ +FP KWTAPEA FT KSDVWSFGI+
Sbjct: 374 LVSESLMCKIADFGLARVIE-DNEYTAREGAKFPIKWTAPEAINFGCFTIKSDVWSFGIL 432
Query: 366 MYEILTWASPPYPDTPAKEVIDKVSSGYRMPNPEKFIPGARCPDEIYKIMLNCWNVLPEE 545
+YEI+T+ PYP +V+ +S GYRMP E CPDE+Y IM CW EE
Sbjct: 433 LYEIVTYGKIPYPGRTNADVMTALSQGYRMPRME------NCPDELYDIMKMCWKESAEE 486
Query: 546 RPTFASLQEQMDTLIVDNTG 605
RPTF LQ +D G
Sbjct: 487 RPTFDYLQSVLDDFYTATEG 506
>sp|P25911|LYN_MOUSE Tyrosine-protein kinase Lyn
Length = 512
Score = 192 bits (488), Expect = 7e-49
Identities = 95/200 (47%), Positives = 129/200 (64%)
Frame = +3
Query: 6 PMIIIVEFMKNGSLKEYLKSEDGKQIILSQMIHMMAEISEGMAYLEGEKVVHRDLRADNI 185
P+ II EFM GSL ++LKS++G +++L ++I A+I+EGMAY+E + +HRDLRA N+
Sbjct: 314 PIYIITEFMAKGSLLDFLKSDEGGKVLLPKLIDFSAQIAEGMAYIERKNYIHRDLRAANV 373
Query: 186 LVADDLTVKVADFGLTELTEGNNDSQEKKNLRFPYKWTAPEAAKTKIFTSKSDVWSFGIV 365
LV++ L K+ADFGL + E +N+ ++ +FP KWTAPEA FT KSDVWSFGI+
Sbjct: 374 LVSESLMCKIADFGLARVIE-DNEYTAREGAKFPIKWTAPEAINFGCFTIKSDVWSFGIL 432
Query: 366 MYEILTWASPPYPDTPAKEVIDKVSSGYRMPNPEKFIPGARCPDEIYKIMLNCWNVLPEE 545
+YEI+T+ PYP +V+ +S GYRMP E CPDE+Y IM CW EE
Sbjct: 433 LYEIVTYGKIPYPGRTNADVMSALSQGYRMPRME------NCPDELYDIMKMCWKEKAEE 486
Query: 546 RPTFASLQEQMDTLIVDNTG 605
RPTF LQ +D G
Sbjct: 487 RPTFDYLQSVLDDFYTATEG 506
>sp|P07948|LYN_HUMAN Tyrosine-protein kinase Lyn
Length = 512
Score = 191 bits (484), Expect = 2e-48
Identities = 94/200 (47%), Positives = 129/200 (64%)
Frame = +3
Query: 6 PMIIIVEFMKNGSLKEYLKSEDGKQIILSQMIHMMAEISEGMAYLEGEKVVHRDLRADNI 185
P+ II E+M GSL ++LKS++G +++L ++I A+I+EGMAY+E + +HRDLRA N+
Sbjct: 314 PIYIITEYMAKGSLLDFLKSDEGGKVLLPKLIDFSAQIAEGMAYIERKNYIHRDLRAANV 373
Query: 186 LVADDLTVKVADFGLTELTEGNNDSQEKKNLRFPYKWTAPEAAKTKIFTSKSDVWSFGIV 365
LV++ L K+ADFGL + E +N+ ++ +FP KWTAPEA FT KSDVWSFGI+
Sbjct: 374 LVSESLMCKIADFGLARVIE-DNEYTAREGAKFPIKWTAPEAINFGCFTIKSDVWSFGIL 432
Query: 366 MYEILTWASPPYPDTPAKEVIDKVSSGYRMPNPEKFIPGARCPDEIYKIMLNCWNVLPEE 545
+YEI+T+ PYP +V+ +S GYRMP E CPDE+Y IM CW EE
Sbjct: 433 LYEIVTYGKIPYPGRTNADVMTALSQGYRMPRVE------NCPDELYDIMKMCWKEKAEE 486
Query: 546 RPTFASLQEQMDTLIVDNTG 605
RPTF LQ +D G
Sbjct: 487 RPTFDYLQSVLDDFYTATEG 506
>sp|Q95KR7|LCK_SAISC Proto-oncogene tyrosine-protein kinase LCK (p56-LCK) (Lymphocyte
cell-specific protein-tyrosine kinase)
Length = 509
Score = 191 bits (484), Expect = 2e-48
Identities = 93/200 (46%), Positives = 130/200 (65%)
Frame = +3
Query: 6 PMIIIVEFMKNGSLKEYLKSEDGKQIILSQMIHMMAEISEGMAYLEGEKVVHRDLRADNI 185
P+ II E+M+NGSL ++LK+ G ++ +++++ M A+I EGMA+LE +HRDLRA NI
Sbjct: 311 PIYIITEYMENGSLVDFLKTPSGIKLTINKLLDMAAQIVEGMAFLEERNYIHRDLRAANI 370
Query: 186 LVADDLTVKVADFGLTELTEGNNDSQEKKNLRFPYKWTAPEAAKTKIFTSKSDVWSFGIV 365
LV+D L+ K+ADFGL L E +N+ ++ +FP KWTAPEA FT KSDVWSFGI+
Sbjct: 371 LVSDTLSCKIADFGLARLIE-DNEYTAREGAKFPIKWTAPEAINYGTFTIKSDVWSFGIL 429
Query: 366 MYEILTWASPPYPDTPAKEVIDKVSSGYRMPNPEKFIPGARCPDEIYKIMLNCWNVLPEE 545
M EI+T PYP EVI + GYRMP P+ CP+E+YK+M+ CW P++
Sbjct: 430 MTEIVTHGRIPYPGMTNPEVIQNLERGYRMPRPD------NCPEELYKLMMQCWRERPDD 483
Query: 546 RPTFASLQEQMDTLIVDNTG 605
RPTF L+ ++ G
Sbjct: 484 RPTFDYLRSVLEDFFTATEG 503
>sp|P50545|HCK_RAT Tyrosine-protein kinase HCK (p56-HCK) (Hemopoietic cell kinase)
Length = 503
Score = 190 bits (482), Expect = 4e-48
Identities = 94/192 (48%), Positives = 125/192 (65%)
Frame = +3
Query: 6 PMIIIVEFMKNGSLKEYLKSEDGKQIILSQMIHMMAEISEGMAYLEGEKVVHRDLRADNI 185
P+ I+ EFM GSL ++LKSE+G + L ++I A+ISEGMA++E +HRDLRA NI
Sbjct: 305 PIFIVTEFMAKGSLLDFLKSEEGSKQPLPKLIDFSAQISEGMAFIEQRNYIHRDLRAANI 364
Query: 186 LVADDLTVKVADFGLTELTEGNNDSQEKKNLRFPYKWTAPEAAKTKIFTSKSDVWSFGIV 365
LV+ L K+ADFGL + E +N+ ++ +FP KWTAPEA FT KSDVWSFGI+
Sbjct: 365 LVSASLVCKIADFGLARIIE-DNEYTAREGAKFPIKWTAPEAINFGSFTIKSDVWSFGIL 423
Query: 366 MYEILTWASPPYPDTPAKEVIDKVSSGYRMPNPEKFIPGARCPDEIYKIMLNCWNVLPEE 545
+ EI+T+ PYP EVI + GYRMP P+ CP+E+Y IM+ CW PEE
Sbjct: 424 LMEIVTYGRIPYPGMSNPEVIRALEHGYRMPRPD------NCPEELYSIMIRCWKNRPEE 477
Query: 546 RPTFASLQEQMD 581
RPTF +Q +D
Sbjct: 478 RPTFEYIQSVLD 489
>sp|P08103|HCK_MOUSE Tyrosine-protein kinase HCK (p56-HCK/p59-HCK) (Hemopoietic cell
kinase) (B-cell/myeloid kinase) (BMK)
Length = 524
Score = 190 bits (482), Expect = 4e-48
Identities = 94/192 (48%), Positives = 125/192 (65%)
Frame = +3
Query: 6 PMIIIVEFMKNGSLKEYLKSEDGKQIILSQMIHMMAEISEGMAYLEGEKVVHRDLRADNI 185
P+ I+ EFM GSL ++LKSE+G + L ++I A+ISEGMA++E +HRDLRA NI
Sbjct: 326 PIFIVTEFMAKGSLLDFLKSEEGSKQPLPKLIDFSAQISEGMAFIEQRNYIHRDLRAANI 385
Query: 186 LVADDLTVKVADFGLTELTEGNNDSQEKKNLRFPYKWTAPEAAKTKIFTSKSDVWSFGIV 365
LV+ L K+ADFGL + E +N+ ++ +FP KWTAPEA FT KSDVWSFGI+
Sbjct: 386 LVSASLVCKIADFGLARIIE-DNEYTAREGAKFPIKWTAPEAINFGSFTIKSDVWSFGIL 444
Query: 366 MYEILTWASPPYPDTPAKEVIDKVSSGYRMPNPEKFIPGARCPDEIYKIMLNCWNVLPEE 545
+ EI+T+ PYP EVI + GYRMP P+ CP+E+Y IM+ CW PEE
Sbjct: 445 LMEIVTYGRIPYPGMSNPEVIRALEHGYRMPRPD------NCPEELYNIMIRCWKNRPEE 498
Query: 546 RPTFASLQEQMD 581
RPTF +Q +D
Sbjct: 499 RPTFEYIQSVLD 510
>sp|P08631|HCK_HUMAN Tyrosine-protein kinase HCK (p59-HCK/p60-HCK) (Hemopoietic cell
kinase)
Length = 526
Score = 188 bits (478), Expect = 1e-47
Identities = 94/192 (48%), Positives = 125/192 (65%)
Frame = +3
Query: 6 PMIIIVEFMKNGSLKEYLKSEDGKQIILSQMIHMMAEISEGMAYLEGEKVVHRDLRADNI 185
P+ II EFM GSL ++LKS++G + L ++I A+I+EGMA++E +HRDLRA NI
Sbjct: 328 PIYIITEFMAKGSLLDFLKSDEGSKQPLPKLIDFSAQIAEGMAFIEQRNYIHRDLRAANI 387
Query: 186 LVADDLTVKVADFGLTELTEGNNDSQEKKNLRFPYKWTAPEAAKTKIFTSKSDVWSFGIV 365
LV+ L K+ADFGL + E +N+ ++ +FP KWTAPEA FT KSDVWSFGI+
Sbjct: 388 LVSASLVCKIADFGLARVIE-DNEYTAREGAKFPIKWTAPEAINFGSFTIKSDVWSFGIL 446
Query: 366 MYEILTWASPPYPDTPAKEVIDKVSSGYRMPNPEKFIPGARCPDEIYKIMLNCWNVLPEE 545
+ EI+T+ PYP EVI + GYRMP PE CP+E+Y IM+ CW PEE
Sbjct: 447 LMEIVTYGRIPYPGMSNPEVIRALERGYRMPRPE------NCPEELYNIMMRCWKNRPEE 500
Query: 546 RPTFASLQEQMD 581
RPTF +Q +D
Sbjct: 501 RPTFEYIQSVLD 512
>sp|P42683|LCK_CHICK Proto-oncogene tyrosine-protein kinase LCK (Protein-tyrosine kinase
C-TKL) (p56tk1)
Length = 508
Score = 188 bits (477), Expect = 1e-47
Identities = 89/200 (44%), Positives = 131/200 (65%)
Frame = +3
Query: 6 PMIIIVEFMKNGSLKEYLKSEDGKQIILSQMIHMMAEISEGMAYLEGEKVVHRDLRADNI 185
P+ II E+M+ GSL ++LK+ +G ++ +++++ M A+I+EGMA++E + +HRDLRA NI
Sbjct: 310 PIYIITEYMEKGSLVDFLKTSEGIKLSINKLLDMAAQIAEGMAFIEAKNYIHRDLRAANI 369
Query: 186 LVADDLTVKVADFGLTELTEGNNDSQEKKNLRFPYKWTAPEAAKTKIFTSKSDVWSFGIV 365
LV++ L K+ADFGL L E +N+ ++ +FP KWTAPEA FT KSDVWSFGI+
Sbjct: 370 LVSEALCCKIADFGLARLIE-DNEYTAREGAKFPIKWTAPEAINYGTFTIKSDVWSFGIL 428
Query: 366 MYEILTWASPPYPDTPAKEVIDKVSSGYRMPNPEKFIPGARCPDEIYKIMLNCWNVLPEE 545
+ EI+T+ PYP EVI + GYRMP P+ CP E+Y++M+ CW PEE
Sbjct: 429 LTEIVTYGRIPYPGMTNPEVIQNLERGYRMPQPD------NCPQELYELMMQCWKEQPEE 482
Query: 546 RPTFASLQEQMDTLIVDNTG 605
RPTF ++ ++ G
Sbjct: 483 RPTFEYMKSVLEDFFTATEG 502
>sp|P00526|SRC_RSVP Tyrosine-protein kinase transforming protein Src (p60-Src) (v-Src)
(pp60v-src)
Length = 526
Score = 187 bits (476), Expect = 2e-47
Identities = 95/191 (49%), Positives = 126/191 (65%)
Frame = +3
Query: 6 PMIIIVEFMKNGSLKEYLKSEDGKQIILSQMIHMMAEISEGMAYLEGEKVVHRDLRADNI 185
P+ I++E+M GSL ++LK E GK + L Q++ M A+I+ GMAY+E VHRDLRA NI
Sbjct: 333 PIYIVIEYMSKGSLLDFLKGEMGKYLRLPQLVDMAAQIASGMAYVERMNYVHRDLRAANI 392
Query: 186 LVADDLTVKVADFGLTELTEGNNDSQEKKNLRFPYKWTAPEAAKTKIFTSKSDVWSFGIV 365
LV ++L KVADFGL L E +N+ ++ +FP KWTAPEAA FT KSDVWSFGI+
Sbjct: 393 LVGENLVCKVADFGLARLIE-DNEYTARQGAKFPIKWTAPEAALYGRFTIKSDVWSFGIL 451
Query: 366 MYEILTWASPPYPDTPAKEVIDKVSSGYRMPNPEKFIPGARCPDEIYKIMLNCWNVLPEE 545
+ E+ T PYP +EV+D+V GYRMP P + CP+ ++ +M CW PEE
Sbjct: 452 LTELTTKGRVPYPGMVNREVLDQVERGYRMPCPPE------CPESLHDLMCQCWRKDPEE 505
Query: 546 RPTFASLQEQM 578
RPTF LQ Q+
Sbjct: 506 RPTFKYLQAQL 516
Database: Non-redundant SwissProt sequences
Posted date: Dec 6, 2005 7:40 AM
Number of letters in database: 68,354,980
Number of sequences in database: 184,735
Database: swissprot.01
Posted date: Dec 6, 2005 8:18 AM
Number of letters in database: 66,202,850
Number of sequences in database: 184,431
Lambda K H
0.318 0.134 0.401
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 80,591,189
Number of Sequences: 369166
Number of extensions: 1656809
Number of successful extensions: 8090
Number of sequences better than 10.0: 10
Number of HSP's better than 10.0 without gapping: 6066
Number of HSP's successfully gapped in prelim test: 0
Number of HSP's that attempted gapping in prelim test: 0
Number of HSP's gapped (non-prelim): 6303
length of database: 68,354,980
effective HSP length: 107
effective length of database: 48,588,335
effective search space used: 6170718545
frameshift window, decay const: 40, 0.1
T: 12
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)