Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= Dr_sW_005_J10
(950 letters)
Database: Non-redundant SwissProt sequences
184,735 sequences; 68,354,980 total letters
Score E
Sequences producing significant alignments: (bits) Value
sp|Q8CBE3|WDR37_MOUSE WD-repeat protein 37 188 2e-47
sp|Q9Y2I8|WD37_HUMAN WD-repeat protein 37 186 8e-47
sp|Q8YRI1|YY46_ANASP Hypothetical WD-repeat protein alr3466 75 3e-13
sp|P56093|TUP1_CANAL Transcriptional repressor TUP1 74 6e-13
sp|Q91WQ5|TAF5L_MOUSE TAF5-like RNA polymerase II p300/CBP-... 73 1e-12
sp|P49027|GBLP_ORYSA Guanine nucleotide-binding protein bet... 72 2e-12
sp|O18640|GBLP_DROME Guanine nucleotide-binding protein bet... 71 5e-12
sp|O75529|TAF5L_HUMAN TAF5-like RNA polymerase II p300/CBP-... 70 9e-12
sp|Q7KNS3|LIS1_DROME Lissencephaly-1 homolog (Lissencephaly... 69 1e-11
sp|P38129|TAF5_YEAST Transcription initiation factor TFIID ... 69 1e-11
>sp|Q8CBE3|WDR37_MOUSE WD-repeat protein 37
Length = 496
Score = 188 bits (477), Expect = 2e-47
Identities = 105/213 (49%), Positives = 136/213 (63%), Gaps = 3/213 (1%)
Frame = +3
Query: 156 AADFLLNRDQLVTASWDRLGRIYDIATGSEVASLTGHDLPLTDVRTNPVADHALAVTASR 335
AAD+L+ Q+VTASWDR +YD+ T V SLTGHD LT T+P L VT+SR
Sbjct: 288 AADWLVGGKQVVTASWDRTANLYDVETSELVHSLTGHDQELTHCCTHPT--QRLVVTSSR 345
Query: 336 DCTFRLWDFRCSSTE-VHVQQGHNGIVSSVSFVGNSSEKLVSAGADRACKIWDLRNSRNP 512
D TFRLWDFR S V+V QGH V+S F + +VS DR K+WDL+N R+P
Sbjct: 346 DTTFRLWDFRDPSIHSVNVFQGHTDTVTSAVFT--VGDNVVSGSDDRTVKVWDLKNMRSP 403
Query: 513 LHVIRTDSPINRLAVHPHGKIVALPMDNRSVKVFDLNLGTRIARLPRNSNQSHTRIVTSI 692
+ IRTDS INR+ V KI+ALP DNR V++FD++ G R+ARLPR+S Q H R+V
Sbjct: 404 IATIRTDSAINRINVCVGQKIIALPHDNRQVRLFDMS-GVRLARLPRSSRQGHRRMVCCS 462
Query: 693 AWNADGGGKP--NFYSAGFDQQLIAWHLQLPTL 785
AW+ D P N ++ GFD+Q I W++ +P L
Sbjct: 463 AWSED---HPICNLFTCGFDRQAIGWNINIPAL 492
>sp|Q9Y2I8|WD37_HUMAN WD-repeat protein 37
Length = 494
Score = 186 bits (472), Expect = 8e-47
Identities = 103/211 (48%), Positives = 134/211 (63%), Gaps = 1/211 (0%)
Frame = +3
Query: 156 AADFLLNRDQLVTASWDRLGRIYDIATGSEVASLTGHDLPLTDVRTNPVADHALAVTASR 335
A+D+L+ Q VTASWDR +YD+ T V SLTGHD LT T+P L VT+SR
Sbjct: 286 ASDWLVGGKQAVTASWDRTANLYDVETSELVHSLTGHDQELTHCCTHPT--QRLVVTSSR 343
Query: 336 DCTFRLWDFRCSSTE-VHVQQGHNGIVSSVSFVGNSSEKLVSAGADRACKIWDLRNSRNP 512
D TFRLWDFR S V+V QGH V+S F + +VS DR K+WDL+N R+P
Sbjct: 344 DTTFRLWDFRDPSIHSVNVFQGHTDTVTSAVFT--VGDNVVSGSDDRTVKVWDLKNMRSP 401
Query: 513 LHVIRTDSPINRLAVHPHGKIVALPMDNRSVKVFDLNLGTRIARLPRNSNQSHTRIVTSI 692
+ IRTDS INR+ V KI+ALP DNR V++FD++ G R+ARLPR+S Q H R+V
Sbjct: 402 IATIRTDSAINRINVCVGQKIIALPHDNRQVRLFDMS-GVRLARLPRSSRQGHRRMVCCS 460
Query: 693 AWNADGGGKPNFYSAGFDQQLIAWHLQLPTL 785
AW+ D N ++ GFD+Q I W++ +P L
Sbjct: 461 AWSED-HPVCNLFTCGFDRQAIGWNINIPAL 490
>sp|Q8YRI1|YY46_ANASP Hypothetical WD-repeat protein alr3466
Length = 1526
Score = 75.1 bits (183), Expect = 3e-13
Identities = 57/202 (28%), Positives = 101/202 (50%)
Frame = +3
Query: 165 FLLNRDQLVTASWDRLGRIYDIATGSEVASLTGHDLPLTDVRTNPVADHALAVTASRDCT 344
F N L S D++ R++DI++ + +L GH + V +P D A + S D T
Sbjct: 1124 FSPNGVTLANGSSDQIVRLWDISSKKCLYTLQGHTNWVNAVAFSP--DGATLASGSGDQT 1181
Query: 345 FRLWDFRCSSTEVHVQQGHNGIVSSVSFVGNSSEKLVSAGADRACKIWDLRNSRNPLHVI 524
RLWD SS +++ QGH V+SV F + S L S +D+ ++W++ +S+
Sbjct: 1182 VRLWDI-SSSKCLYILQGHTSWVNSVVFNPDGS-TLASGSSDQTVRLWEINSSKCLCTFQ 1239
Query: 525 RTDSPINRLAVHPHGKIVALPMDNRSVKVFDLNLGTRIARLPRNSNQSHTRIVTSIAWNA 704
S +N + +P G ++A +++V+++D++ + ++ Q HT V S+A+N
Sbjct: 1240 GHTSWVNSVVFNPDGSMLASGSSDKTVRLWDISSSKCL-----HTFQGHTNWVNSVAFNP 1294
Query: 705 DGGGKPNFYSAGFDQQLIAWHL 770
DG S DQ + W +
Sbjct: 1295 DGS---MLASGSGDQTVRLWEI 1313
Score = 70.1 bits (170), Expect = 9e-12
Identities = 54/207 (26%), Positives = 101/207 (48%)
Frame = +3
Query: 150 LSAADFLLNRDQLVTASWDRLGRIYDIATGSEVASLTGHDLPLTDVRTNPVADHALAVTA 329
+++ F + L + S D+ R++DI++G + + GH + V +P + + +
Sbjct: 909 VNSVGFSQDGKMLASGSDDQTVRLWDISSGQCLKTFKGHTSRVRSVVFSP--NSLMLASG 966
Query: 330 SRDCTFRLWDFRCSSTEVHVQQGHNGIVSSVSFVGNSSEKLVSAGADRACKIWDLRNSRN 509
S D T RLWD S +++ QGH G V SV+F + S L + D+ ++WD+ +S+
Sbjct: 967 SSDQTVRLWDI-SSGECLYIFQGHTGWVYSVAFNLDGS-MLATGSGDQTVRLWDISSSQC 1024
Query: 510 PLHVIRTDSPINRLAVHPHGKIVALPMDNRSVKVFDLNLGTRIARLPRNSNQSHTRIVTS 689
S + + G ++A D+++V+++D++ G + L Q HT V S
Sbjct: 1025 FYIFQGHTSCVRSVVFSSDGAMLASGSDDQTVRLWDISSGNCLYTL-----QGHTSCVRS 1079
Query: 690 IAWNADGGGKPNFYSAGFDQQLIAWHL 770
+ ++ DG S G DQ + W +
Sbjct: 1080 VVFSPDGA---MLASGGDDQIVRLWDI 1103
Score = 68.6 bits (166), Expect = 3e-11
Identities = 55/204 (26%), Positives = 105/204 (51%), Gaps = 1/204 (0%)
Frame = +3
Query: 150 LSAADFLLNRDQLVTASWDRLGRIYDIATGSEVASLTGHDLPLTDVRTNPVADHALAVTA 329
++A F + L + S D+ R++DI++ + L GH + V NP D + +
Sbjct: 1161 VNAVAFSPDGATLASGSGDQTVRLWDISSSKCLYILQGHTSWVNSVVFNP--DGSTLASG 1218
Query: 330 SRDCTFRLWDFRCSSTEVHVQQGHNGIVSSVSFVGNSSEKLVSAGADRACKIWDLRNSRN 509
S D T RLW+ SS + QGH V+SV F + S L S +D+ ++WD+ +S+
Sbjct: 1219 SSDQTVRLWEIN-SSKCLCTFQGHTSWVNSVVFNPDGS-MLASGSSDKTVRLWDISSSK- 1275
Query: 510 PLHVIRTDSP-INRLAVHPHGKIVALPMDNRSVKVFDLNLGTRIARLPRNSNQSHTRIVT 686
LH + + +N +A +P G ++A +++V++++++ + ++ Q HT V+
Sbjct: 1276 CLHTFQGHTNWVNSVAFNPDGSMLASGSGDQTVRLWEISSSKCL-----HTFQGHTSWVS 1330
Query: 687 SIAWNADGGGKPNFYSAGFDQQLI 758
S+ ++ DG ++G D Q +
Sbjct: 1331 SVTFSPDG----TMLASGSDDQTV 1350
Score = 62.4 bits (150), Expect = 2e-09
Identities = 51/196 (26%), Positives = 96/196 (48%), Gaps = 1/196 (0%)
Frame = +3
Query: 186 LVTASWDRLGRIYDIATGSEVASLTGHDLPLTDVRTNPVADHALAVTASRDCTFRLWDFR 365
L + S D+ R++DI++G+ + +L GH + V +P D A+ + D RLWD
Sbjct: 1047 LASGSDDQTVRLWDISSGNCLYTLQGHTSCVRSVVFSP--DGAMLASGGDDQIVRLWDI- 1103
Query: 366 CSSTEVHVQQGHNGIVSSVSFVGNSSEKLVSAGADRACKIWDLRNSRNPLHVIRTDSP-I 542
S ++ QG+ V + F N L + +D+ ++WD+ +S+ L+ ++ + +
Sbjct: 1104 SSGNCLYTLQGYTSWVRFLVFSPN-GVTLANGSSDQIVRLWDI-SSKKCLYTLQGHTNWV 1161
Query: 543 NRLAVHPHGKIVALPMDNRSVKVFDLNLGTRIARLPRNSNQSHTRIVTSIAWNADGGGKP 722
N +A P G +A +++V+++D++ + L Q HT V S+ +N DG
Sbjct: 1162 NAVAFSPDGATLASGSGDQTVRLWDISSSKCLYIL-----QGHTSWVNSVVFNPDGS--- 1213
Query: 723 NFYSAGFDQQLIAWHL 770
S DQ + W +
Sbjct: 1214 TLASGSSDQTVRLWEI 1229
Score = 54.7 bits (130), Expect = 4e-07
Identities = 47/182 (25%), Positives = 88/182 (48%), Gaps = 1/182 (0%)
Frame = +3
Query: 216 RIYDIATGSEVASLTGHDLPLTDVRTNPVADHALAVTASRDCTFRLWDFRCSSTEVHVQQ 395
R ++ ATG E+ + GH+ + V + D + + S D T RLWD S + +
Sbjct: 889 RFWEAATGKELLTCKGHNSWVNSVGFS--QDGKMLASGSDDQTVRLWDI-SSGQCLKTFK 945
Query: 396 GHNGIVSSVSFVGNSSEKLVSAGADRACKIWDLRNSRNPLHVIRTDSP-INRLAVHPHGK 572
GH V SV F NS L S +D+ ++WD+ +S L++ + + + +A + G
Sbjct: 946 GHTSRVRSVVFSPNSL-MLASGSSDQTVRLWDI-SSGECLYIFQGHTGWVYSVAFNLDGS 1003
Query: 573 IVALPMDNRSVKVFDLNLGTRIARLPRNSNQSHTRIVTSIAWNADGGGKPNFYSAGFDQQ 752
++A +++V+++D++ Q HT V S+ +++DG ++G D Q
Sbjct: 1004 MLATGSGDQTVRLWDISSSQCFYIF-----QGHTSCVRSVVFSSDGA----MLASGSDDQ 1054
Query: 753 LI 758
+
Sbjct: 1055 TV 1056
>sp|P56093|TUP1_CANAL Transcriptional repressor TUP1
Length = 514
Score = 73.9 bits (180), Expect = 6e-13
Identities = 55/213 (25%), Positives = 98/213 (46%), Gaps = 16/213 (7%)
Frame = +3
Query: 183 QLVTASWDRLGRIYDIATGSEVASLTGH--------------DLPLTDVRTNPVADHALA 320
+ + ++ +++++ TG VA L DL + V +P D L
Sbjct: 215 KFIATGCNKTTQVFNVTTGELVAKLIDESSNENKDDNTTASGDLYIRSVCFSP--DGKLL 272
Query: 321 VTASRDCTFRLWDFRCSSTEVHVQQGHNGIVSSVSFVGNSSEKLVSAGADRACKIWDLRN 500
T + D R+WD + + +GH + S+ F + ++LVS DR+ +IWDLR
Sbjct: 273 ATGAEDKLIRIWDLSTKRI-IKILRGHEQDIYSLDFFPDG-DRLVSGSGDRSVRIWDLRT 330
Query: 501 SRNPLHVIRTDSPINRLAVHPHGKIVALPMDNRSVKVFDLNLGTRIARLP--RNSNQSHT 674
S+ L + + + +AV P GK++A +R+V+V+D G + RL + H
Sbjct: 331 SQCSL-TLSIEDGVTTVAVSPDGKLIAAGSLDRTVRVWDSTTGFLVERLDSGNENGNGHE 389
Query: 675 RIVTSIAWNADGGGKPNFYSAGFDQQLIAWHLQ 773
V S+A++ +G S D+ + WHL+
Sbjct: 390 DSVYSVAFSNNG---EQIASGSLDRTVKLWHLE 419
Score = 56.6 bits (135), Expect = 1e-07
Identities = 57/207 (27%), Positives = 89/207 (42%), Gaps = 14/207 (6%)
Frame = +3
Query: 162 DFLLNRDQLVTASWDRLGRIYDIATGSEVASLTGHDLPLTDVRTNPVADHALAVTASRDC 341
DF + D+LV+ S DR RI+D+ T +L+ D +T V +P D L S D
Sbjct: 306 DFFPDGDRLVSGSGDRSVRIWDLRTSQCSLTLSIED-GVTTVAVSP--DGKLIAAGSLDR 362
Query: 342 TFRLWDFRCSSTEVHVQQ---------GHNGIVSSVSFVGNSSEKLVSAGADRACKIWDL 494
T R+WD S+T V++ GH V SV+F N+ E++ S DR K+W L
Sbjct: 363 TVRVWD---STTGFLVERLDSGNENGNGHEDSVYSVAF-SNNGEQIASGSLDRTVKLWHL 418
Query: 495 -----RNSRNPLHVIRTDSPINRLAVHPHGKIVALPMDNRSVKVFDLNLGTRIARLPRNS 659
+ S + I + + P + + +R V +D G + L
Sbjct: 419 EGKSDKKSTCEVTYIGHKDFVLSVCCTPDNEYILSGSKDRGVIFWDQASGNPLLML---- 474
Query: 660 NQSHTRIVTSIAWNADGGGKPNFYSAG 740
Q H V S+A + + G ++ G
Sbjct: 475 -QGHRNSVISVAVSLNSKGTEGIFATG 500
>sp|Q91WQ5|TAF5L_MOUSE TAF5-like RNA polymerase II p300/CBP-associated factor-associated
factor 65 kDa subunit 5L (PCAF-associated factor 65
beta) (PAF65-beta)
Length = 589
Score = 72.8 bits (177), Expect = 1e-12
Identities = 55/214 (25%), Positives = 97/214 (45%)
Frame = +3
Query: 147 PLSAADFLLNRDQLVTASWDRLGRIYDIATGSEVASLTGHDLPLTDVRTNPVADHALAVT 326
P+ + FL + L++ S D R +D+ + + GH P+ DV +P + + +
Sbjct: 344 PVYSTRFLADSSGLLSCSEDMSIRYWDLGSFTNTVLYQGHAYPVWDVDISPFSLYF--AS 401
Query: 327 ASRDCTFRLWDFRCSSTEVHVQQGHNGIVSSVSFVGNSSEKLVSAGADRACKIWDLRNSR 506
S D T RLW F + + + GH V V F NS+ L + D+ ++W +
Sbjct: 402 GSHDRTARLWSFD-RTYPLRIYAGHLADVDCVKFHPNSNY-LATGSTDKTVRLWSAQQGN 459
Query: 507 NPLHVIRTDSPINRLAVHPHGKIVALPMDNRSVKVFDLNLGTRIARLPRNSNQSHTRIVT 686
+ P+ L+ P+GK +A +++ +K++DL GT L + HT +T
Sbjct: 460 SVRLFTGHRGPVLSLSFSPNGKYLASAGEDQRLKLWDLASGTLFKEL-----RGHTDSIT 514
Query: 687 SIAWNADGGGKPNFYSAGFDQQLIAWHLQLPTLN 788
S+A++ D G SA D + W ++ N
Sbjct: 515 SLAFSPDSG---LIASASMDNSVRVWDIRSTCCN 545
>sp|P49027|GBLP_ORYSA Guanine nucleotide-binding protein beta subunit-like protein
(GPB-LR) (RWD)
Length = 334
Score = 72.4 bits (176), Expect = 2e-12
Identities = 50/163 (30%), Positives = 82/163 (50%), Gaps = 6/163 (3%)
Frame = +3
Query: 189 VTASWDRLGRIYDIATGSEVASLTGHDLPLTDVRTNPVADHALAVTASRDCTFRLWDF-- 362
++ SWD R++D++TG GHD + V + D+ V+ASRD T +LW+
Sbjct: 91 LSGSWDGELRLWDLSTGVTTRRFVGHDKDVLSVAFS--VDNRQIVSASRDRTIKLWNTLG 148
Query: 363 RCSST---EVHVQQGHNGIVSSVSFVGNSSEKLVSAGA-DRACKIWDLRNSRNPLHVIRT 530
C T ++ +GHNG VS V F N+ + + +G+ DR K+W+L N + ++
Sbjct: 149 ECKYTIGGDLGGGEGHNGWVSCVRFSPNTFQPTIVSGSWDRTVKVWNLTNCKLRCNLEGH 208
Query: 531 DSPINRLAVHPHGKIVALPMDNRSVKVFDLNLGTRIARLPRNS 659
+N +AV P G + A + ++DL G R+ L S
Sbjct: 209 GGYVNAVAVSPDGSLCASGGKDGVTLLWDLAEGKRLYSLDAGS 251
Score = 39.3 bits (90), Expect = 0.017
Identities = 29/121 (23%), Positives = 56/121 (46%)
Frame = +3
Query: 186 LVTASWDRLGRIYDIATGSEVASLTGHDLPLTDVRTNPVADHALAVTASRDCTFRLWDFR 365
+V+ SWDR +++++ +L GH + V +P D +L + +D LWD
Sbjct: 182 IVSGSWDRTVKVWNLTNCKLRCNLEGHGGYVNAVAVSP--DGSLCASGGKDGVTLLWDLA 239
Query: 366 CSSTEVHVQQGHNGIVSSVSFVGNSSEKLVSAGADRACKIWDLRNSRNPLHVIRTDSPIN 545
+ G I+ S+ F N + A + KIWDL S++ + ++ + P++
Sbjct: 240 EGKRLYSLDAG--SIIHSLCFSPN--RYWLCAATQDSIKIWDL-ESKHIVQDLKPEIPVS 294
Query: 546 R 548
+
Sbjct: 295 K 295
Score = 38.9 bits (89), Expect = 0.022
Identities = 35/144 (24%), Positives = 64/144 (44%), Gaps = 17/144 (11%)
Frame = +3
Query: 387 VQQGHNGIVSSVSFVGNSSEKLVSAGADRACKIWDLRNSRNPLHVIRTDS-------PIN 545
V GHN +V++++ ++S +VS+ D++ +WDL NP+ + + P
Sbjct: 13 VMHGHNDVVTAIATPIDNSPFIVSSSRDKSLLVWDL---TNPVQNVGEGAGASEYGVPFR 69
Query: 546 RLAVHPH-GKIVALPMDNR---------SVKVFDLNLGTRIARLPRNSNQSHTRIVTSIA 695
RL H H + V L D + ++++DL+ G R H + V S+A
Sbjct: 70 RLTGHSHFVQDVVLSSDGQFALSGSWDGELRLWDLSTGVTTRRF-----VGHDKDVLSVA 124
Query: 696 WNADGGGKPNFYSAGFDQQLIAWH 767
++ D SA D+ + W+
Sbjct: 125 FSVD---NRQIVSASRDRTIKLWN 145
Score = 30.8 bits (68), Expect = 5.9
Identities = 37/193 (19%), Positives = 78/193 (40%), Gaps = 15/193 (7%)
Frame = +3
Query: 261 GHDLPLTDVRTNPVADHALAVTASRDCTFRLWDFR---------CSSTEVHVQ----QGH 401
GH+ +T + T P+ + V++SRD + +WD ++E V GH
Sbjct: 16 GHNDVVTAIAT-PIDNSPFIVSSSRDKSLLVWDLTNPVQNVGEGAGASEYGVPFRRLTGH 74
Query: 402 NGIVSSVSFVGNSSEKLVSAGADRACKIWDLRNSRNPLHVIRTDSPINRLAVHPHGKIVA 581
+ V V + + + +S D ++WDL + D + +A + +
Sbjct: 75 SHFVQDV-VLSSDGQFALSGSWDGELRLWDLSTGVTTRRFVGHDKDVLSVAFSVDNRQIV 133
Query: 582 LPMDNRSVKVFDLNLGTRIARL--PRNSNQSHTRIVTSIAWNADGGGKPNFYSAGFDQQL 755
+R++K+++ LG + + H V+ + ++ + +P S +D+ +
Sbjct: 134 SASRDRTIKLWN-TLGECKYTIGGDLGGGEGHNGWVSCVRFSPN-TFQPTIVSGSWDRTV 191
Query: 756 IAWHLQLPTLNIN 794
W+L L N
Sbjct: 192 KVWNLTNCKLRCN 204
>sp|O18640|GBLP_DROME Guanine nucleotide-binding protein beta subunit-like protein
(Receptor of activated protein kinase C homolog)
Length = 318
Score = 70.9 bits (172), Expect = 5e-12
Identities = 49/169 (28%), Positives = 78/169 (46%), Gaps = 3/169 (1%)
Frame = +3
Query: 159 ADFLLNRD--QLVTASWDRLGRIYDIATGSEVASLTGHDLPLTDVRTNPVADHALAVTAS 332
+D +L+ D ++ SWD+ R++D+A G GH + V + AD+ V+ S
Sbjct: 68 SDVVLSSDGNYALSGSWDQTLRLWDLAAGKTTRRFEGHTKDVLSVAFS--ADNRQIVSGS 125
Query: 333 RDCTFRLWDFRCSSTEVHVQQGHNGIVSSVSFVGNSSEK-LVSAGADRACKIWDLRNSRN 509
RD T +LW+ + GH VS V F N S +VS G DR K+W+L N +
Sbjct: 126 RDKTIKLWNTLAECKFTIQEDGHTDWVSCVRFSPNHSNPIIVSCGWDRTVKVWNLANCKL 185
Query: 510 PLHVIRTDSPINRLAVHPHGKIVALPMDNRSVKVFDLNLGTRIARLPRN 656
+ + +N + V P G + + ++DLN G + L N
Sbjct: 186 KNNHHGHNGYLNTVTVSPDGSLCTSGGKDSKALLWDLNDGKNLYTLEHN 234
Score = 35.8 bits (81), Expect = 0.18
Identities = 27/114 (23%), Positives = 49/114 (42%), Gaps = 10/114 (8%)
Frame = +3
Query: 396 GHNGIVSSVSFVGNSSEKLVSAGADRACKIWDLRNSRNPLHVIRTDSPINRLAVHPH--- 566
GHNG V+ ++ + ++SA D+ +W L + + P RL H H
Sbjct: 13 GHNGWVTQIATNPKDPDTIISASRDKTLIVWKLTRDEDTNY----GYPQKRLYGHSHFIS 68
Query: 567 -------GKIVALPMDNRSVKVFDLNLGTRIARLPRNSNQSHTRIVTSIAWNAD 707
G +++++++DL G R + HT+ V S+A++AD
Sbjct: 69 DVVLSSDGNYALSGSWDQTLRLWDLAAGKTTRRF-----EGHTKDVLSVAFSAD 117
>sp|O75529|TAF5L_HUMAN TAF5-like RNA polymerase II p300/CBP-associated factor-associated
factor 65 kDa subunit 5L (PCAF-associated factor 65
beta) (PAF65-beta)
Length = 589
Score = 70.1 bits (170), Expect = 9e-12
Identities = 53/209 (25%), Positives = 95/209 (45%)
Frame = +3
Query: 147 PLSAADFLLNRDQLVTASWDRLGRIYDIATGSEVASLTGHDLPLTDVRTNPVADHALAVT 326
P+ + FL + L++ S D R +D+ + + GH P+ D+ +P + + +
Sbjct: 344 PVYSTRFLADSSGLLSCSEDMSIRYWDLGSFTNTVLYQGHAYPVWDLDISPYSLYF--AS 401
Query: 327 ASRDCTFRLWDFRCSSTEVHVQQGHNGIVSSVSFVGNSSEKLVSAGADRACKIWDLRNSR 506
S D T RLW F + + + GH V V F NS+ L + D+ ++W +
Sbjct: 402 GSHDRTARLWSFD-RTYPLRIYAGHLADVDCVKFHPNSNY-LATGSTDKTVRLWSAQQGN 459
Query: 507 NPLHVIRTDSPINRLAVHPHGKIVALPMDNRSVKVFDLNLGTRIARLPRNSNQSHTRIVT 686
+ P+ LA P+GK +A +++ +K++DL GT L + HT +T
Sbjct: 460 SVRLFTGHRGPVLSLAFSPNGKYLASAGEDQRLKLWDLASGTLYKEL-----RGHTDNIT 514
Query: 687 SIAWNADGGGKPNFYSAGFDQQLIAWHLQ 773
S+ ++ D G SA D + W ++
Sbjct: 515 SLTFSPDSG---LIASASMDNSVRVWDIR 540
Score = 55.8 bits (133), Expect = 2e-07
Identities = 42/154 (27%), Positives = 72/154 (46%), Gaps = 11/154 (7%)
Frame = +3
Query: 75 NPNSMY-------QTASLYSSFGSYTYK----DSAPLSAADFLLNRDQLVTASWDRLGRI 221
+P S+Y +TA L+S +Y + A + F N + L T S D+ R+
Sbjct: 393 SPYSLYFASGSHDRTARLWSFDRTYPLRIYAGHLADVDCVKFHPNSNYLATGSTDKTVRL 452
Query: 222 YDIATGSEVASLTGHDLPLTDVRTNPVADHALAVTASRDCTFRLWDFRCSSTEVHVQQGH 401
+ G+ V TGH P+ + +P + +A D +LWD S T +GH
Sbjct: 453 WSAQQGNSVRLFTGHRGPVLSLAFSPNGKYL--ASAGEDQRLKLWDL-ASGTLYKELRGH 509
Query: 402 NGIVSSVSFVGNSSEKLVSAGADRACKIWDLRNS 503
++S++F +S + SA D + ++WD+RN+
Sbjct: 510 TDNITSLTFSPDSG-LIASASMDNSVRVWDIRNT 542
Score = 47.8 bits (112), Expect = 5e-05
Identities = 48/188 (25%), Positives = 81/188 (43%), Gaps = 1/188 (0%)
Frame = +3
Query: 225 DIATGSEVASLTGHDLPLTDVRTNPVADHALAVTASRDCTFRLWDFRCSSTEVHVQQGHN 404
D G+E+ L GH P+ R +AD + ++ S D + R WD S T + QGH
Sbjct: 328 DDNAGTEMKILRGHCGPVYSTRF--LADSSGLLSCSEDMSIRYWDLG-SFTNTVLYQGHA 384
Query: 405 GIVSSVSFVGNSSEKLVSAGADRACKIWDLRNSRNPLHVIRTD-SPINRLAVHPHGKIVA 581
V + + S S DR ++W + PL + + ++ + HP+ +A
Sbjct: 385 YPVWDLD-ISPYSLYFASGSHDRTARLWSFDRTY-PLRIYAGHLADVDCVKFHPNSNYLA 442
Query: 582 LPMDNRSVKVFDLNLGTRIARLPRNSNQSHTRIVTSIAWNADGGGKPNFYSAGFDQQLIA 761
+++V+++ G + H V S+A++ +G SAG DQ+L
Sbjct: 443 TGSTDKTVRLWSAQQGNSVRLFT-----GHRGPVLSLAFSPNG---KYLASAGEDQRLKL 494
Query: 762 WHLQLPTL 785
W L TL
Sbjct: 495 WDLASGTL 502
>sp|Q7KNS3|LIS1_DROME Lissencephaly-1 homolog (Lissencephaly1) (Dlis1) (DLis-1)
Length = 411
Score = 69.3 bits (168), Expect = 1e-11
Identities = 54/189 (28%), Positives = 86/189 (45%)
Frame = +3
Query: 186 LVTASWDRLGRIYDIATGSEVASLTGHDLPLTDVRTNPVADHALAVTASRDCTFRLWDFR 365
+V+AS D RI+D TG SL GH + DV + A L + S D + +LWDF+
Sbjct: 123 MVSASEDATIRIWDFETGEYERSLKGHTDSVQDVAFD--AQGKLLASCSADLSIKLWDFQ 180
Query: 366 CSSTEVHVQQGHNGIVSSVSFVGNSSEKLVSAGADRACKIWDLRNSRNPLHVIRTDSPIN 545
S + GH+ VSSV+FV + + ++SA DR K+W++ +
Sbjct: 181 QSYECIKTMHGHDHNVSSVAFV-PAGDYVLSASRDRTIKMWEVATGYCVKTYTGHREWVR 239
Query: 546 RLAVHPHGKIVALPMDNRSVKVFDLNLGTRIARLPRNSNQSHTRIVTSIAWNADGGGKPN 725
+ VH G I A ++++++V+ N L + H V IAW +
Sbjct: 240 MVRVHIEGSIFATCSNDQTIRVWLTNSKDCKVEL-----RDHEHTVECIAWAPEAAASAI 294
Query: 726 FYSAGFDQQ 752
+AG D +
Sbjct: 295 NEAAGADNK 303
Score = 61.6 bits (148), Expect = 3e-09
Identities = 42/130 (32%), Positives = 66/130 (50%), Gaps = 1/130 (0%)
Frame = +3
Query: 243 EVASLTGHDLPLTDVRTNPVADHALAVTASRDCTFRLWDFRCSSTEVHVQQGHNGIVSSV 422
E SLTGH +T V +P+ AL V+AS D T R+WDF E + +GH V V
Sbjct: 100 EKFSLTGHRASITRVIFHPI--FALMVSASEDATIRIWDFETGEYERSL-KGHTDSVQDV 156
Query: 423 SFVGNSSEKLVSAGADRACKIWDLRNSRNPLHVIR-TDSPINRLAVHPHGKIVALPMDNR 599
+F + L S AD + K+WD + S + + D ++ +A P G V +R
Sbjct: 157 AF-DAQGKLLASCSADLSIKLWDFQQSYECIKTMHGHDHNVSSVAFVPAGDYVLSASRDR 215
Query: 600 SVKVFDLNLG 629
++K++++ G
Sbjct: 216 TIKMWEVATG 225
Score = 60.1 bits (144), Expect = 9e-09
Identities = 53/223 (23%), Positives = 98/223 (43%), Gaps = 18/223 (8%)
Frame = +3
Query: 150 LSAADFLLNRDQLVTASWDRLGRIYDIATGSEVASLTGHDLPLTDVRTNPVADHALAVTA 329
+S+ F+ D +++AS DR +++++ATG V + TGH + VR + + ++ T
Sbjct: 196 VSSVAFVPAGDYVLSASRDRTIKMWEVATGYCVKTYTGHREWVRMVRVH--IEGSIFATC 253
Query: 330 SRDCTFRLWDFRCSSTEVHVQQGHNGI----------VSSVSFVGNSSEK--------LV 455
S D T R+W +V ++ + + S+++ + K L
Sbjct: 254 SNDQTIRVWLTNSKDCKVELRDHEHTVECIAWAPEAAASAINEAAGADNKKGHHQGPFLA 313
Query: 456 SAGADRACKIWDLRNSRNPLHVIRTDSPINRLAVHPHGKIVALPMDNRSVKVFDLNLGTR 635
S D+ +IWD+ L + D+ + LA HP GK + D+++++V+DL
Sbjct: 314 SGSRDKTIRIWDVSVGLCLLTLSGHDNWVRGLAFHPGGKYLVSASDDKTIRVWDLRNKRC 373
Query: 636 IARLPRNSNQSHTRIVTSIAWNADGGGKPNFYSAGFDQQLIAW 764
+ L +H TSI ++ P S DQ + W
Sbjct: 374 MKTL-----YAHQHFCTSIDFHK---AHPYVISGSVDQTVKVW 408
>sp|P38129|TAF5_YEAST Transcription initiation factor TFIID subunit 5 (TBP-associated
factor 5) (TBP-associated factor 90 kDa) (TAFII-90)
Length = 798
Score = 69.3 bits (168), Expect = 1e-11
Identities = 51/215 (23%), Positives = 102/215 (47%), Gaps = 1/215 (0%)
Frame = +3
Query: 141 SAPLSAADFLLNRDQLVTASWDRLGRIYDIATGSEVASLTGHDLPLTDVRTNPVADHALA 320
S + + F + L++ S D+ R++ + T + + S GH+ P+ DV +P+ +
Sbjct: 525 SGTVYSTSFSPDNKYLLSGSEDKTVRLWSMDTHTALVSYKGHNHPVWDVSFSPLGHYF-- 582
Query: 321 VTASRDCTFRLWDFRCSST-EVHVQQGHNGIVSSVSFVGNSSEKLVSAGADRACKIWDLR 497
TAS D T RLW C + + GH V VSF N + + +D+ C++WD+
Sbjct: 583 ATASHDQTARLWS--CDHIYPLRIFAGHLNDVDCVSFHPNGCY-VFTGSSDKTCRMWDVS 639
Query: 498 NSRNPLHVIRTDSPINRLAVHPHGKIVALPMDNRSVKVFDLNLGTRIARLPRNSNQSHTR 677
+ + +P+ +AV P G+ ++ ++ + V+D+ G R+ ++ + +
Sbjct: 640 TGDSVRLFLGHTAPVISIAVCPDGRWLSTGSEDGIINVWDIGTGKRLKQMRGHGKNA--- 696
Query: 678 IVTSIAWNADGGGKPNFYSAGFDQQLIAWHLQLPT 782
+ S++++ +G S G D + W L+ T
Sbjct: 697 -IYSLSYSKEGN---VLISGGADHTVRVWDLKKAT 727
Database: Non-redundant SwissProt sequences
Posted date: Dec 6, 2005 7:40 AM
Number of letters in database: 68,354,980
Number of sequences in database: 184,735
Database: swissprot.01
Posted date: Dec 6, 2005 8:18 AM
Number of letters in database: 66,202,850
Number of sequences in database: 184,431
Lambda K H
0.318 0.134 0.401
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 107,917,484
Number of Sequences: 369166
Number of extensions: 2143811
Number of successful extensions: 6880
Number of sequences better than 10.0: 10
Number of HSP's better than 10.0 without gapping: 5540
Number of HSP's successfully gapped in prelim test: 0
Number of HSP's that attempted gapping in prelim test: 0
Number of HSP's gapped (non-prelim): 6322
length of database: 68,354,980
effective HSP length: 110
effective length of database: 48,034,130
effective search space used: 9895030780
frameshift window, decay const: 40, 0.1
T: 12
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)