Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= Dr_sW_005_I22
(900 letters)
Database: Non-redundant SwissProt sequences
184,735 sequences; 68,354,980 total letters
Score E
Sequences producing significant alignments: (bits) Value
sp|O14427|CLA4_CANAL Serine/threonine-protein kinase CLA4 108 3e-23
sp|P38692|KIC1_YEAST Serine/threonine-protein kinase KIC1 (... 102 1e-21
sp|Q9VXE5|PAKM_DROME Serine/threonine-protein kinase PAK mb... 102 1e-21
sp|Q10056|SHK2_SCHPO Serine/threonine-protein kinase shk2 101 2e-21
sp|Q17850|PAK1_CAEEL Serine/threonine-protein kinase pak-1 ... 100 4e-21
sp|Q64303|PAK2_RAT Serine/threonine-protein kinase PAK 2 (p... 100 4e-21
sp|Q8CIN4|PAK2_MOUSE Serine/threonine-protein kinase PAK 2 ... 100 4e-21
sp|Q13177|PAK2_HUMAN Serine/threonine-protein kinase PAK 2 ... 100 4e-21
sp|Q29502|PAK2_RABIT Serine/threonine-protein kinase PAK 2 ... 100 4e-21
sp|P35465|PAK1_RAT Serine/threonine-protein kinase PAK 1 (p... 100 6e-21
>sp|O14427|CLA4_CANAL Serine/threonine-protein kinase CLA4
Length = 971
Score = 108 bits (269), Expect = 3e-23
Identities = 65/223 (29%), Positives = 114/223 (51%), Gaps = 10/223 (4%)
Frame = +1
Query: 253 LKKLSEGAFGQIYF-------NAEIVLKKPLRKNDEEIESLYRDISMNSMFKYLNSLERY 411
++K +GA G +Y N +I +K+ E + +I + ++ N +
Sbjct: 683 VEKAGQGASGNVYLAEMIKDNNRKIAIKQMDLDAQPRKELIINEILVMKDSQHKNIVNFL 742
Query: 412 INLALENETVCLVMKYLSGGSLRAHIEKSKI-IQEREISKICFQLLKQIKDIHALNIIHR 588
+ + + + ++M+Y+ GGSL IE + + E++I+ ICF+ LK ++ +H +IIHR
Sbjct: 743 DSYLIGDNELWVIMEYMQGGSLTEIIENNDFKLNEKQIATICFETLKGLQHLHKKHIIHR 802
Query: 589 DINCDNIVLDQYGNARIIDYGISKCINEASAVQLKEDLSKK--IFGNIRYCAPEYLAAKA 762
DI DN++LD YGN +I D+G +L + +K+ + G + APE + K
Sbjct: 803 DIKSDNVLLDAYGNVKITDFGF--------CAKLTDQRNKRATMVGTPYWMAPEVVKQKE 854
Query: 763 YTKRIDIWSLGAVVITMATGKEPYYGNNDVVAARKIVETKTIK 891
Y +++D+WSLG + I M G+ PY + A I T K
Sbjct: 855 YDEKVDVWSLGIMTIEMIEGEPPYLNEEPLKALYLIATNGTPK 897
>sp|P38692|KIC1_YEAST Serine/threonine-protein kinase KIC1 (Kinase that interacts with
CDC31) (N-rich kinase 1)
Length = 1080
Score = 102 bits (255), Expect = 1e-21
Identities = 61/215 (28%), Positives = 113/215 (52%), Gaps = 8/215 (3%)
Frame = +1
Query: 262 LSEGAFGQIYFNAEIVLKKP-------LRKNDEEIESLYRDISMNSMFKYLNSLERYINL 420
+ G FG +Y + + L + +E+E + R+I + K ++++ RY
Sbjct: 29 IGRGKFGVVYKGYNVKTGRVYAIKVLNLDSDSDEVEDVQREIQFLASLKQISNITRYYGS 88
Query: 421 ALENETVCLVMKYLSGGSLRAHIEKSKIIQEREISKICFQLLKQIKDIHALNIIHRDINC 600
L++ ++ ++M++ +GGSLR+ + KI E+ I I +LL +K IH N+IHRDI
Sbjct: 89 YLKDTSLWIIMEHCAGGSLRSLLRPGKI-DEKYIGVIMRELLVALKCIHKDNVIHRDIKA 147
Query: 601 DNIVLDQYGNARIIDYGISKCINEASAVQLKEDLSKKIFGNIRYCAPEYLAAKA-YTKRI 777
N+++ GN ++ D+G++ +N+ S + + + G + APE + Y ++
Sbjct: 148 ANVLITNEGNVKLCDFGVAAQVNQTSLRR------QTMAGTPYWMAPEVIMEGVYYDTKV 201
Query: 778 DIWSLGAVVITMATGKEPYYGNNDVVAARKIVETK 882
DIWSLG +ATG PY + A + I+++K
Sbjct: 202 DIWSLGITTYEIATGNPPYCDVEALRAMQLIIKSK 236
>sp|Q9VXE5|PAKM_DROME Serine/threonine-protein kinase PAK mbt (p21-activated kinase
related protein) (Mushroom bodies tiny protein)
Length = 639
Score = 102 bits (255), Expect = 1e-21
Identities = 61/219 (27%), Positives = 114/219 (52%), Gaps = 8/219 (3%)
Frame = +1
Query: 238 DRYDELKKLSEGAFGQIYF------NAEIVLKKPLRKNDEEIESLYRDISMNSMFKYLNS 399
+ D K+ EG+ G + ++ +KK + + E L+ ++ + + + N
Sbjct: 366 ENLDHFNKIGEGSTGTVCIATDKSTGRQVAVKKMDLRKQQRRELLFNEVVIMRDYHHPNI 425
Query: 400 LERYINLALENETVCLVMKYLSGGSLRAHIEKSKIIQEREISKICFQLLKQIKDIHALNI 579
+E Y + L N+ + +VM+YL GG+L + S++ E +I+ +C Q LK + +H+ +
Sbjct: 426 VETYSSF-LVNDELWVVMEYLEGGALTDIVTHSRM-DEEQIATVCKQCLKALAYLHSQGV 483
Query: 580 IHRDINCDNIVLDQYGNARIIDYGISKCINEASAVQLKEDLSKK--IFGNIRYCAPEYLA 753
IHRDI D+I+L G ++ D+G Q+ ++L K+ + G + +PE ++
Sbjct: 484 IHRDIKSDSILLAADGRVKLSDFGF--------CAQVSQELPKRKSLVGTPYWMSPEVIS 535
Query: 754 AKAYTKRIDIWSLGAVVITMATGKEPYYGNNDVVAARKI 870
Y +DIWSLG +VI M G+ P++ + A R+I
Sbjct: 536 RLPYGPEVDIWSLGIMVIEMVDGEPPFFNEPPLQAMRRI 574
>sp|Q10056|SHK2_SCHPO Serine/threonine-protein kinase shk2
Length = 589
Score = 101 bits (252), Expect = 2e-21
Identities = 73/223 (32%), Positives = 116/223 (52%), Gaps = 14/223 (6%)
Frame = +1
Query: 259 KLSEGAFGQIYFNAEIVLKKPLRKNDE-EIESL------YRDISMNSMFKYLNSLERYIN 417
KL +GA G +Y A++V K L D I+S+ +++ +N + S+ I
Sbjct: 314 KLGQGASGSVYL-AKVVGGKQLGIFDSVAIKSIDLQCQTRKELILNEITVMRESIHPNIV 372
Query: 418 LALENETV-----CLVMKYLSGGSLRAHIEKSKIIQEREISKICFQLLKQIKDIHALNII 582
L++ V +VM+Y++ GSL IEKSK+ E +I++IC + K I+ +HA NII
Sbjct: 373 TYLDSFLVRERHLWVVMEYMNAGSLTDIIEKSKLT-EAQIARICLETCKGIQHLHARNII 431
Query: 583 HRDINCDNIVLDQYGNARIIDYGISKCINEASAVQLKEDLSKKI--FGNIRYCAPEYLAA 756
HRDI DN++LD GN +I D+G +L +K++ G + APE +
Sbjct: 432 HRDIKSDNVLLDNSGNIKITDFGF--------CARLSNRTNKRVTMVGTPYWMAPEVVKQ 483
Query: 757 KAYTKRIDIWSLGAVVITMATGKEPYYGNNDVVAARKIVETKT 885
Y ++DIWSLG ++I M + PY + + A I + T
Sbjct: 484 NEYGTKVDIWSLGIMIIEMIENEPPYLREDPIRALYLIAKNGT 526
>sp|Q17850|PAK1_CAEEL Serine/threonine-protein kinase pak-1 (p21-activated kinase 1)
(PAK1) (CePAK)
Length = 572
Score = 100 bits (250), Expect = 4e-21
Identities = 61/214 (28%), Positives = 116/214 (54%), Gaps = 8/214 (3%)
Frame = +1
Query: 241 RYDELKKLSEGAFGQIYF------NAEIVLKKPLRKNDEEIESLYRDISMNSMFKYLNSL 402
+Y ++ K+ GA G +Y AE+ +K+ K+ + E + +I + K+ N +
Sbjct: 294 KYRKVDKIGSGASGSVYTAIEISTEAEVAIKQMNLKDQPKKELIINEILVMRENKHAN-I 352
Query: 403 ERYINLALENETVCLVMKYLSGGSLRAHIEKSKIIQEREISKICFQLLKQIKDIHALNII 582
Y++ L + + +VM+YL+GGSL + + ++ ++ I+ +C ++L+ ++ +H+ ++I
Sbjct: 353 VNYLDSYLVCDELWVVMEYLAGGSLTDVVTECQM-EDGIIAAVCREVLQALEFLHSRHVI 411
Query: 583 HRDINCDNIVLDQYGNARIIDYGISKCINEASAVQLKEDLSKK--IFGNIRYCAPEYLAA 756
HRDI DNI+L G+ ++ D+G QL + K+ + G + APE +
Sbjct: 412 HRDIKSDNILLGMDGSVKLTDFGF--------CAQLSPEQRKRTTMVGTPYWMAPEVVTR 463
Query: 757 KAYTKRIDIWSLGAVVITMATGKEPYYGNNDVVA 858
K Y ++D+WSLG + I M G+ PY N + A
Sbjct: 464 KQYGPKVDVWSLGIMAIEMVEGEPPYLNENPLRA 497
>sp|Q64303|PAK2_RAT Serine/threonine-protein kinase PAK 2 (p21-activated kinase 2)
(PAK-2) (Gamma-PAK) (p62-PAK)
Length = 524
Score = 100 bits (250), Expect = 4e-21
Identities = 62/223 (27%), Positives = 115/223 (51%), Gaps = 8/223 (3%)
Frame = +1
Query: 241 RYDELKKLSEGAFGQIY------FNAEIVLKKPLRKNDEEIESLYRDISMNSMFKYLNSL 402
+Y +K+ +GA G ++ E+ +K+ + + E + +I + K N +
Sbjct: 248 KYTRYEKIGQGASGTVFTATDVALGQEVAIKQINLQKQPKKELIINEILVMKELKNPN-I 306
Query: 403 ERYINLALENETVCLVMKYLSGGSLRAHIEKSKIIQEREISKICFQLLKQIKDIHALNII 582
+++ L + + +VM+YL+GGSL + ++ + E +I+ +C + L+ ++ +HA +I
Sbjct: 307 VNFLDSYLVGDELFVVMEYLAGGSLTDVVTET-CMDEAQIAAVCRECLQALEFLHANQVI 365
Query: 583 HRDINCDNIVLDQYGNARIIDYGISKCINEASAVQLKEDLSKK--IFGNIRYCAPEYLAA 756
HRDI DN++L G+ ++ D+G Q+ + SK+ + G + APE +
Sbjct: 366 HRDIKSDNVLLGMEGSVKLTDFGF--------CAQITPEQSKRSTMVGTPYWMAPEVVTR 417
Query: 757 KAYTKRIDIWSLGAVVITMATGKEPYYGNNDVVAARKIVETKT 885
KAY ++DIWSLG + I M G+ PY N + A I T
Sbjct: 418 KAYGPKVDIWSLGIMAIEMVEGEPPYLNENPLRALYLIATNGT 460
>sp|Q8CIN4|PAK2_MOUSE Serine/threonine-protein kinase PAK 2 (p21-activated kinase 2)
(PAK-2)
Length = 524
Score = 100 bits (250), Expect = 4e-21
Identities = 62/223 (27%), Positives = 115/223 (51%), Gaps = 8/223 (3%)
Frame = +1
Query: 241 RYDELKKLSEGAFGQIY------FNAEIVLKKPLRKNDEEIESLYRDISMNSMFKYLNSL 402
+Y +K+ +GA G ++ E+ +K+ + + E + +I + K N +
Sbjct: 248 KYTRYEKIGQGASGTVFTATDVALGQEVAIKQINLQKQPKKELIINEILVMKELKNPN-I 306
Query: 403 ERYINLALENETVCLVMKYLSGGSLRAHIEKSKIIQEREISKICFQLLKQIKDIHALNII 582
+++ L + + +VM+YL+GGSL + ++ + E +I+ +C + L+ ++ +HA +I
Sbjct: 307 VNFLDSYLVGDELFVVMEYLAGGSLTDVVTET-CMDEAQIAAVCRECLQALEFLHANQVI 365
Query: 583 HRDINCDNIVLDQYGNARIIDYGISKCINEASAVQLKEDLSKK--IFGNIRYCAPEYLAA 756
HRDI DN++L G+ ++ D+G Q+ + SK+ + G + APE +
Sbjct: 366 HRDIKSDNVLLGMEGSVKLTDFGF--------CAQITPEQSKRSTMVGTPYWMAPEVVTR 417
Query: 757 KAYTKRIDIWSLGAVVITMATGKEPYYGNNDVVAARKIVETKT 885
KAY ++DIWSLG + I M G+ PY N + A I T
Sbjct: 418 KAYGPKVDIWSLGIMAIEMVEGEPPYLNENPLRALYLIATNGT 460
>sp|Q13177|PAK2_HUMAN Serine/threonine-protein kinase PAK 2 (p21-activated kinase 2)
(PAK-2) (PAK65) (Gamma-PAK) (S6/H4 kinase)
Length = 524
Score = 100 bits (250), Expect = 4e-21
Identities = 62/223 (27%), Positives = 115/223 (51%), Gaps = 8/223 (3%)
Frame = +1
Query: 241 RYDELKKLSEGAFGQIY------FNAEIVLKKPLRKNDEEIESLYRDISMNSMFKYLNSL 402
+Y +K+ +GA G ++ E+ +K+ + + E + +I + K N +
Sbjct: 248 KYTRYEKIGQGASGTVFTATDVALGQEVAIKQINLQKQPKKELIINEILVMKELKNPN-I 306
Query: 403 ERYINLALENETVCLVMKYLSGGSLRAHIEKSKIIQEREISKICFQLLKQIKDIHALNII 582
+++ L + + +VM+YL+GGSL + ++ + E +I+ +C + L+ ++ +HA +I
Sbjct: 307 VNFLDSYLVGDELFVVMEYLAGGSLTDVVTET-CMDEAQIAAVCRECLQALEFLHANQVI 365
Query: 583 HRDINCDNIVLDQYGNARIIDYGISKCINEASAVQLKEDLSKK--IFGNIRYCAPEYLAA 756
HRDI DN++L G+ ++ D+G Q+ + SK+ + G + APE +
Sbjct: 366 HRDIKSDNVLLGMEGSVKLTDFGF--------CAQITPEQSKRSTMVGTPYWMAPEVVTR 417
Query: 757 KAYTKRIDIWSLGAVVITMATGKEPYYGNNDVVAARKIVETKT 885
KAY ++DIWSLG + I M G+ PY N + A I T
Sbjct: 418 KAYGPKVDIWSLGIMAIEMVEGEPPYLNENPLRALYLIATNGT 460
>sp|Q29502|PAK2_RABIT Serine/threonine-protein kinase PAK 2 (p21-activated kinase 2)
(PAK-2) (Gamma-PAK) (p21-activated protein kinase I)
(PAKI)
Length = 524
Score = 100 bits (250), Expect = 4e-21
Identities = 62/223 (27%), Positives = 115/223 (51%), Gaps = 8/223 (3%)
Frame = +1
Query: 241 RYDELKKLSEGAFGQIY------FNAEIVLKKPLRKNDEEIESLYRDISMNSMFKYLNSL 402
+Y +K+ +GA G ++ E+ +K+ + + E + +I + K N +
Sbjct: 248 KYTRYEKIGQGASGTVFTATDVALGQEVAIKQINLQKQPKKELIINEILVMKELKNPN-I 306
Query: 403 ERYINLALENETVCLVMKYLSGGSLRAHIEKSKIIQEREISKICFQLLKQIKDIHALNII 582
+++ L + + +VM+YL+GGSL + ++ + E +I+ +C + L+ ++ +HA +I
Sbjct: 307 VNFLDSYLVGDELFVVMEYLAGGSLTDVVTET-CMDEAQIAAVCRECLQALEFLHANQVI 365
Query: 583 HRDINCDNIVLDQYGNARIIDYGISKCINEASAVQLKEDLSKK--IFGNIRYCAPEYLAA 756
HRDI DN++L G+ ++ D+G Q+ + SK+ + G + APE +
Sbjct: 366 HRDIKSDNVLLGMEGSVKLTDFGF--------CAQITPEQSKRSTMVGTPYWMAPEVVTR 417
Query: 757 KAYTKRIDIWSLGAVVITMATGKEPYYGNNDVVAARKIVETKT 885
KAY ++DIWSLG + I M G+ PY N + A I T
Sbjct: 418 KAYGPKVDIWSLGIMAIEMVEGEPPYLNENPLRALYLIATNGT 460
>sp|P35465|PAK1_RAT Serine/threonine-protein kinase PAK 1 (p21-activated kinase 1)
(PAK-1) (P68-PAK) (Alpha-PAK) (Protein kinase MUK2)
Length = 544
Score = 100 bits (249), Expect = 6e-21
Identities = 64/223 (28%), Positives = 115/223 (51%), Gaps = 8/223 (3%)
Frame = +1
Query: 241 RYDELKKLSEGAFGQIYF------NAEIVLKKPLRKNDEEIESLYRDISMNSMFKYLNSL 402
+Y +K+ +GA G +Y E+ +K+ + + E + +I + K N +
Sbjct: 268 KYTRFEKIGQGASGTVYTAMDVATGQEVAIKQMNLQQQPKKELIINEILVMRENKNPN-I 326
Query: 403 ERYINLALENETVCLVMKYLSGGSLRAHIEKSKIIQEREISKICFQLLKQIKDIHALNII 582
Y++ L + + +VM+YL+GGSL + ++ + E +I+ +C + L+ ++ +H+ +I
Sbjct: 327 VNYLDSYLVGDELWVVMEYLAGGSLTDVVTET-CMDEGQIAAVCRECLQALEFLHSNQVI 385
Query: 583 HRDINCDNIVLDQYGNARIIDYGISKCINEASAVQLKEDLSKK--IFGNIRYCAPEYLAA 756
HRDI DNI+L G+ ++ D+G Q+ + SK+ + G + APE +
Sbjct: 386 HRDIKSDNILLGMDGSVKLTDFGF--------CAQITPEQSKRSTMVGTPYWMAPEVVTR 437
Query: 757 KAYTKRIDIWSLGAVVITMATGKEPYYGNNDVVAARKIVETKT 885
KAY ++DIWSLG + I M G+ PY N + A I T
Sbjct: 438 KAYGPKVDIWSLGIMAIEMIEGEPPYLNENPLRALYLIATNGT 480
Database: Non-redundant SwissProt sequences
Posted date: Dec 6, 2005 7:40 AM
Number of letters in database: 68,354,980
Number of sequences in database: 184,735
Database: swissprot.01
Posted date: Dec 6, 2005 8:18 AM
Number of letters in database: 66,202,850
Number of sequences in database: 184,431
Lambda K H
0.318 0.134 0.401
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 101,517,912
Number of Sequences: 369166
Number of extensions: 2082777
Number of successful extensions: 9526
Number of sequences better than 10.0: 10
Number of HSP's better than 10.0 without gapping: 7512
Number of HSP's successfully gapped in prelim test: 0
Number of HSP's that attempted gapping in prelim test: 0
Number of HSP's gapped (non-prelim): 7857
length of database: 68,354,980
effective HSP length: 110
effective length of database: 48,034,130
effective search space used: 9078450570
frameshift window, decay const: 40, 0.1
T: 12
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)