Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= Dr_sW_005_F24
(941 letters)
Database: Non-redundant SwissProt sequences
184,735 sequences; 68,354,980 total letters
Score E
Sequences producing significant alignments: (bits) Value
sp|Q62433|NDRG1_MOUSE NDRG1 protein (N-myc downstream regul... 110 4e-24
sp|Q92597|NDRG1_HUMAN NDRG1 protein (N-myc downstream regul... 109 1e-23
sp|Q9Z2L9|NDRG4_RAT NDRG4 protein (Brain development-relate... 104 3e-22
sp|Q8BTG7|NDRG4_MOUSE NDRG4 protein 104 3e-22
sp|Q9ULP0|NDRG4_HUMAN NDRG4 protein (Brain development-rela... 104 3e-22
sp|Q9UGV2|NDRG3_HUMAN NDRG3 protein 103 5e-22
sp|Q9QYF9|NDRG3_MOUSE NDRG3 protein (Ndr3 protein) 103 7e-22
sp|Q9QYG0|NDRG2_MOUSE NDRG2 protein (Ndr2 protein) 94 4e-19
sp|Q9UN36|NDRG2_HUMAN NDRG2 protein (Syld709613 protein) 92 2e-18
sp|O02485|YDJ1_CAEEL Hypothetical protein ZK1073.1 in chrom... 92 2e-18
>sp|Q62433|NDRG1_MOUSE NDRG1 protein (N-myc downstream regulated gene 1 protein) (Protein
Ndr1)
Length = 394
Score = 110 bits (276), Expect = 4e-24
Identities = 71/226 (31%), Positives = 119/226 (52%), Gaps = 2/226 (0%)
Frame = +3
Query: 54 YPSMAELADIVADVVDHFHIKYFLGFGMGAGCNVLTRYGLLYPNKLLGLFLMNPDDTTTG 233
YPSM +LA+++ V+ F +K +G G GAG +LTR+ L P + GL LMN + G
Sbjct: 112 YPSMDQLAEMLPGVLHQFGLKSVIGMGTGAGAYILTRFALNNPEMVEGLVLMNVNPCAEG 171
Query: 234 YYPWTRAIWSDIPYLKSGVVTDWIQNWLLDHWFG-SCTERNMDLEHSYLQ-LLGELNPVA 407
+ W + K T + + ++ H FG N+++ H+Y Q +L ++NP
Sbjct: 172 WMDWAAS--------KISGWTQALPDMVVSHLFGKEEIHNNVEVVHTYRQHILNDMNPSN 223
Query: 408 VAGYIESYMNRTALGMTRPINSLDTNTSTLKVDAFLVTGEMATDLSRAMVEMNGNMDPTK 587
+ +I +Y +R L + RP+ T+T TL+ A LV G+ + + A+VE N +DPTK
Sbjct: 224 LHLFISAYNSRRDLEIERPMPG--THTVTLQCPALLVVGDNSPAVD-AVVECNSKLDPTK 280
Query: 588 TQFISVIDATGAVMDETPDKLSVLFLNYLRNLGIMVTVTPEKLQRA 725
T + + D G P KL+ F +++ +G M + + +L R+
Sbjct: 281 TTLLKMADCGGLPQISQPAKLAEAFKYFVQGMGYMPSASMTRLMRS 326
>sp|Q92597|NDRG1_HUMAN NDRG1 protein (N-myc downstream regulated gene 1 protein)
(Differentiation-related gene 1 protein) (DRG1)
(Reducing agents and tunicamycin-responsive protein)
(RTP) (Nickel-specific induction protein Cap43) (Rit42)
Length = 394
Score = 109 bits (272), Expect = 1e-23
Identities = 69/226 (30%), Positives = 120/226 (53%), Gaps = 2/226 (0%)
Frame = +3
Query: 54 YPSMAELADIVADVVDHFHIKYFLGFGMGAGCNVLTRYGLLYPNKLLGLFLMNPDDTTTG 233
YPSM +LA+++ V+ F +K +G G GAG +LTR+ L P + GL L+N + G
Sbjct: 112 YPSMDQLAEMLPGVLQQFGLKSIIGMGTGAGAYILTRFALNNPEMVEGLVLINVNPCAEG 171
Query: 234 YYPWTRAIWSDIPYLKSGVVTDWIQNWLLDHWFG-SCTERNMDLEHSYLQ-LLGELNPVA 407
+ W + K T + + ++ H FG + N+++ H+Y Q ++ ++NP
Sbjct: 172 WMDWAAS--------KISGWTQALPDMVVSHLFGKEEMQSNVEVVHTYRQHIVNDMNPGN 223
Query: 408 VAGYIESYMNRTALGMTRPINSLDTNTSTLKVDAFLVTGEMATDLSRAMVEMNGNMDPTK 587
+ +I +Y +R L + RP+ T+T TL+ A LV G+ + + A+VE N +DPTK
Sbjct: 224 LHLFINAYNSRRDLEIERPMPG--THTVTLQCPALLVVGDSSPAVD-AVVECNSKLDPTK 280
Query: 588 TQFISVIDATGAVMDETPDKLSVLFLNYLRNLGIMVTVTPEKLQRA 725
T + + D G P KL+ F +++ +G M + + +L R+
Sbjct: 281 TTLLKMADCGGLPQISQPAKLAEAFKYFVQGMGYMPSASMTRLMRS 326
>sp|Q9Z2L9|NDRG4_RAT NDRG4 protein (Brain development-related molecule 1)
Length = 352
Score = 104 bits (260), Expect = 3e-22
Identities = 71/234 (30%), Positives = 110/234 (47%), Gaps = 2/234 (0%)
Frame = +3
Query: 54 YPSMAELADIVADVVDHFHIKYFLGFGMGAGCNVLTRYGLLYPNKLLGLFLMNPDDTTTG 233
+PSM +LA ++ +VV HF KY +G G+GAG VL ++ L++P+ + GL LMN D G
Sbjct: 86 FPSMEQLATMLPNVVQHFGFKYVIGIGVGAGAYVLAKFALIFPDLVEGLVLMNIDPNGKG 145
Query: 234 YYPWTRAIWSDIPYLKSGVVTDWIQNWLLDHWFG-SCTERNMDLEHSYLQLLGE-LNPVA 407
+ W K +T + + +L H F N +L SY Q + +N
Sbjct: 146 WIDWAAT--------KLSGLTSTLPDTVLSHLFSQEELVNNTELVQSYRQQISSVVNQAN 197
Query: 408 VAGYIESYMNRTALGMTRPINSLDTNTSTLKVDAFLVTGEMATDLSRAMVEMNGNMDPTK 587
+ + Y +R L + RP N TL+ LV G+ A +VE N +DPT
Sbjct: 198 LQLFWNMYNSRRDLDINRP--GTVPNAKTLRCPVMLVVGDNA-PAEDGVVECNSKLDPTT 254
Query: 588 TQFISVIDATGAVMDETPDKLSVLFLNYLRNLGIMVTVTPEKLQRAAVEQQIQT 749
T F+ + D+ G P KL+ F +L+ +G + + +L AV T
Sbjct: 255 TTFLKMADSGGLPQVTQPGKLTEAFKYFLQGMGYIAHLKDRRLSGGAVPSASMT 308
>sp|Q8BTG7|NDRG4_MOUSE NDRG4 protein
Length = 352
Score = 104 bits (260), Expect = 3e-22
Identities = 71/234 (30%), Positives = 109/234 (46%), Gaps = 2/234 (0%)
Frame = +3
Query: 54 YPSMAELADIVADVVDHFHIKYFLGFGMGAGCNVLTRYGLLYPNKLLGLFLMNPDDTTTG 233
+PSM +LA ++ VV HF KY +G G+GAG VL ++ L++P+ + GL LMN D G
Sbjct: 86 FPSMEQLAAMLPSVVQHFGFKYVIGIGVGAGAYVLAKFALIFPDLVEGLVLMNIDPNGKG 145
Query: 234 YYPWTRAIWSDIPYLKSGVVTDWIQNWLLDHWFG-SCTERNMDLEHSYLQLLGE-LNPVA 407
+ W K +T + + +L H F N +L SY Q + +N
Sbjct: 146 WIDWAAT--------KLSGLTSTLPDTVLSHLFSQEELVNNTELVQSYRQQISNVVNQAN 197
Query: 408 VAGYIESYMNRTALGMTRPINSLDTNTSTLKVDAFLVTGEMATDLSRAMVEMNGNMDPTK 587
+ + Y +R L + RP N TL+ LV G+ A +VE N +DPT
Sbjct: 198 LQLFWNMYNSRRDLDINRP--GTVPNAKTLRCPVMLVVGDNA-PAEEGVVECNSKLDPTT 254
Query: 588 TQFISVIDATGAVMDETPDKLSVLFLNYLRNLGIMVTVTPEKLQRAAVEQQIQT 749
T F+ + D+ G P KL+ F +L+ +G + + +L AV T
Sbjct: 255 TTFLKMADSGGLPQVTQPGKLTEAFKYFLQGMGYIAHLKDRRLSGGAVPSASMT 308
>sp|Q9ULP0|NDRG4_HUMAN NDRG4 protein (Brain development-related molecule 1) (Vascular
smooth muscle cell associated protein 8) (SMAP-8)
Length = 352
Score = 104 bits (260), Expect = 3e-22
Identities = 71/234 (30%), Positives = 110/234 (47%), Gaps = 2/234 (0%)
Frame = +3
Query: 54 YPSMAELADIVADVVDHFHIKYFLGFGMGAGCNVLTRYGLLYPNKLLGLFLMNPDDTTTG 233
+PSM +LA ++ VV HF KY +G G+GAG VL ++ L++P+ + GL L+N D G
Sbjct: 86 FPSMEQLAAMLPSVVQHFGFKYVIGIGVGAGAYVLAKFALIFPDLVEGLVLVNIDPNGKG 145
Query: 234 YYPWTRAIWSDIPYLKSGVVTDWIQNWLLDHWFG-SCTERNMDLEHSYLQLLGE-LNPVA 407
+ W K +T + + +L H F N +L SY Q +G +N
Sbjct: 146 WIDWAAT--------KLSGLTSTLPDTVLSHLFSQEELVNNTELVQSYRQQIGNVVNQAN 197
Query: 408 VAGYIESYMNRTALGMTRPINSLDTNTSTLKVDAFLVTGEMATDLSRAMVEMNGNMDPTK 587
+ + Y +R L + RP N TL+ LV G+ A +VE N +DPT
Sbjct: 198 LQLFWNMYNSRRDLDINRP--GTVPNAKTLRCPVMLVVGDNA-PAEDGVVECNSKLDPTT 254
Query: 588 TQFISVIDATGAVMDETPDKLSVLFLNYLRNLGIMVTVTPEKLQRAAVEQQIQT 749
T F+ + D+ G P KL+ F +L+ +G + + +L AV T
Sbjct: 255 TTFLKMADSGGLPQVTQPGKLTEAFKYFLQGMGYIAYLKDRRLSGGAVPSASMT 308
>sp|Q9UGV2|NDRG3_HUMAN NDRG3 protein
Length = 375
Score = 103 bits (258), Expect = 5e-22
Identities = 68/243 (27%), Positives = 121/243 (49%), Gaps = 2/243 (0%)
Frame = +3
Query: 54 YPSMAELADIVADVVDHFHIKYFLGFGMGAGCNVLTRYGLLYPNKLLGLFLMNPDDTTTG 233
YP+M ELA+++ V+ H +K +G G+GAG +L+R+ L +P + GL L+N D G
Sbjct: 110 YPTMDELAEMLPPVLTHLSLKSIIGIGVGAGAYILSRFALNHPELVEGLVLINVDPCAKG 169
Query: 234 YYPWTRAIWSDIPYLKSGVVTDWIQNWLLDHWFGSCTERNMDLEHSY-LQLLGELNPVAV 410
+ W + SG+ T+ + L H+ + N+DL +Y + + ++N +
Sbjct: 170 WIDWAAS-------KLSGLTTNVVDIILAHHFGQEELQANLDLIQTYRMHIAQDINQDNL 222
Query: 411 AGYIESYMNRTALGMTRPI-NSLDTNTSTLKVDAFLVTGEMATDLSRAMVEMNGNMDPTK 587
++ SY R L + RPI D + TLK LV G+ + + A+VE N ++P
Sbjct: 223 QLFLNSYNGRRDLEIERPILGQNDNKSKTLKCSTLLVVGDNSPAV-EAVVECNSRLNPIN 281
Query: 588 TQFISVIDATGAVMDETPDKLSVLFLNYLRNLGIMVTVTPEKLQRAAVEQQIQTAREMQT 767
T + + D G P KL+ F +L+ +G + + + +L R+ T+ + +
Sbjct: 282 TTLLKMADCGGLPQVVQPGKLTEAFKYFLQGMGYIPSASMTRLARSRTH---STSSSLGS 338
Query: 768 GDS 776
G+S
Sbjct: 339 GES 341
>sp|Q9QYF9|NDRG3_MOUSE NDRG3 protein (Ndr3 protein)
Length = 375
Score = 103 bits (257), Expect = 7e-22
Identities = 70/243 (28%), Positives = 119/243 (48%), Gaps = 2/243 (0%)
Frame = +3
Query: 54 YPSMAELADIVADVVDHFHIKYFLGFGMGAGCNVLTRYGLLYPNKLLGLFLMNPDDTTTG 233
YP+M ELA+++ V+ H +K +G G+GAG +L+R+ L +P + GL L+N D G
Sbjct: 110 YPTMDELAEMLPPVLTHLSMKSIIGIGVGAGAYILSRFALNHPELVEGLVLINIDPCAKG 169
Query: 234 YYPWTRAIWSDIPYLKSGVVTDWIQNWLLDHWFGSCTERNMDLEHSY-LQLLGELNPVAV 410
+ W + SG T+ + L H+ + N+DL +Y L + ++N +
Sbjct: 170 WIDWAAS-------KLSGFTTNIVDIILAHHFGQEELQANLDLIQTYRLHIAQDINQENL 222
Query: 411 AGYIESYMNRTALGMTRPI-NSLDTNTSTLKVDAFLVTGEMATDLSRAMVEMNGNMDPTK 587
++ SY R L + RPI D TLK LV G+ + + A+VE N +DP
Sbjct: 223 QLFLGSYNGRRDLEIERPILGQNDNRLKTLKCSTLLVVGDNSPAV-EAVVECNSRLDPIN 281
Query: 588 TQFISVIDATGAVMDETPDKLSVLFLNYLRNLGIMVTVTPEKLQRAAVEQQIQTAREMQT 767
T + + D G P KL+ F +L+ +G + + + +L R+ T+ + +
Sbjct: 282 TTLLKMADCGGLPQVVQPGKLTEAFKYFLQGMGYIPSASMTRLARSRTH---STSSSIGS 338
Query: 768 GDS 776
G+S
Sbjct: 339 GES 341
>sp|Q9QYG0|NDRG2_MOUSE NDRG2 protein (Ndr2 protein)
Length = 371
Score = 94.4 bits (233), Expect = 4e-19
Identities = 67/226 (29%), Positives = 107/226 (47%), Gaps = 2/226 (0%)
Frame = +3
Query: 54 YPSMAELADIVADVVDHFHIKYFLGFGMGAGCNVLTRYGLLYPNKLLGLFLMNPDDTTTG 233
YPS+ +LAD++ ++ + + +G G+GAG +L+RY L +P+ + GL L+N D G
Sbjct: 118 YPSLDQLADMIPCILQYLNFSTIIGVGVGAGAYILSRYALNHPDTVEGLVLINIDPNAKG 177
Query: 234 YYPWTRAIWSDIPYLKSGVVTDWIQNWLLDHWFG-SCTERNMDLEHSYLQLLGEL-NPVA 407
+ W K +T I + +L H F N +L Y ++ N
Sbjct: 178 WMDWAAH--------KLTGLTSSIPDMILGHLFSQEELSGNSELIQKYRGIIQHAPNLEN 229
Query: 408 VAGYIESYMNRTALGMTRPINSLDTNTSTLKVDAFLVTGEMATDLSRAMVEMNGNMDPTK 587
+ Y SY NR R +N +TLK LV G+ A A+VE N +DPT+
Sbjct: 230 IELYWNSYNNR------RDLNFERGGETTLKCPVMLVVGDQAPH-EDAVVECNSKLDPTQ 282
Query: 588 TQFISVIDATGAVMDETPDKLSVLFLNYLRNLGIMVTVTPEKLQRA 725
T F+ + D+ G P KL+ F +L+ +G M + +L R+
Sbjct: 283 TSFLKMADSGGQPQLTQPGKLTEAFKYFLQGMGYMASSCMTRLSRS 328
>sp|Q9UN36|NDRG2_HUMAN NDRG2 protein (Syld709613 protein)
Length = 371
Score = 92.0 bits (227), Expect = 2e-18
Identities = 67/226 (29%), Positives = 104/226 (46%), Gaps = 2/226 (0%)
Frame = +3
Query: 54 YPSMAELADIVADVVDHFHIKYFLGFGMGAGCNVLTRYGLLYPNKLLGLFLMNPDDTTTG 233
YPS+ +LAD++ V+ + + +G G+GAG +L RY L +P+ + GL L+N D G
Sbjct: 118 YPSLDQLADMIPCVLQYLNFSTIIGVGVGAGAYILARYALNHPDTVEGLVLINIDPNAKG 177
Query: 234 YYPWTRAIWSDIPYLKSGVVTDWIQNWLLDHWFG-SCTERNMDLEHSYLQLLGEL-NPVA 407
+ W K +T I +L H F N +L Y ++ N
Sbjct: 178 WMDWAAH--------KLTGLTSSIPEMILGHLFSQEELSGNSELIQKYRNIITHAPNLDN 229
Query: 408 VAGYIESYMNRTALGMTRPINSLDTNTSTLKVDAFLVTGEMATDLSRAMVEMNGNMDPTK 587
+ Y SY NR R +N TL+ LV G+ A A+VE N +DPT+
Sbjct: 230 IELYWNSYNNR------RDLNFERGGDITLRCPVMLVVGDQAPH-EDAVVECNSKLDPTQ 282
Query: 588 TQFISVIDATGAVMDETPDKLSVLFLNYLRNLGIMVTVTPEKLQRA 725
T F+ + D+ G P KL+ F +L+ +G M + +L R+
Sbjct: 283 TSFLKMADSGGQPQLTQPGKLTEAFKYFLQGMGYMASSCMTRLSRS 328
>sp|O02485|YDJ1_CAEEL Hypothetical protein ZK1073.1 in chromosome X
Length = 325
Score = 92.0 bits (227), Expect = 2e-18
Identities = 62/225 (27%), Positives = 117/225 (52%), Gaps = 1/225 (0%)
Frame = +3
Query: 51 NYPSMAELADIVADVVDHFHIKYFLGFGMGAGCNVLTRYGLLYPNKLLGLFLMNPDDTTT 230
++P++ + D ++ V+D F +K + FG G G N++ R+ + +PN+++G+ L++ TT
Sbjct: 85 DFPTLDGIGDDLSAVLDKFEVKSAIAFGEGVGANIICRFAMGHPNRIMGIVLVHCTSTTA 144
Query: 231 GYYPWTRAIWSDIPYLKSGVVTDWIQNWLLDHWFGSCTERNMDLEHSYL-QLLGELNPVA 407
G + + ++ L++ +++D ++LL H FG ++ + YL +L LNP
Sbjct: 145 GIIEYCKEKVMNM-RLENSIMSDGAWDYLLAHKFGGESKSRQE----YLEELKATLNPKN 199
Query: 408 VAGYIESYMNRTALGMTRPINSLDTNTSTLKVDAFLVTGEMATDLSRAMVEMNGNMDPTK 587
++ Y+ ++ RT L T T VDA LVTG A+ L + + +M+ K
Sbjct: 200 LSKYLVAFTKRTDLSST-------IGTKLETVDALLVTGSKASHL-HTVYTTHKSMNKKK 251
Query: 588 TQFISVIDATGAVMDETPDKLSVLFLNYLRNLGIMVTVTPEKLQR 722
T + V+D VM E PDKL+ + + G++ V ++R
Sbjct: 252 TTLL-VVDNVADVMQEAPDKLARSLILLCKGCGVLSGVAIPGMER 295
Database: Non-redundant SwissProt sequences
Posted date: Dec 6, 2005 7:40 AM
Number of letters in database: 68,354,980
Number of sequences in database: 184,735
Database: swissprot.01
Posted date: Dec 6, 2005 8:18 AM
Number of letters in database: 66,202,850
Number of sequences in database: 184,431
Lambda K H
0.318 0.134 0.401
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 119,711,508
Number of Sequences: 369166
Number of extensions: 2720826
Number of successful extensions: 7225
Number of sequences better than 10.0: 10
Number of HSP's better than 10.0 without gapping: 6741
Number of HSP's successfully gapped in prelim test: 0
Number of HSP's that attempted gapping in prelim test: 0
Number of HSP's gapped (non-prelim): 7216
length of database: 68,354,980
effective HSP length: 110
effective length of database: 48,034,130
effective search space used: 9750928390
frameshift window, decay const: 40, 0.1
T: 12
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)