Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= Dr_sW_005_F06
(907 letters)
Database: Non-redundant SwissProt sequences
184,735 sequences; 68,354,980 total letters
Score E
Sequences producing significant alignments: (bits) Value
sp|Q7TMR0|PCP_MOUSE Lysosomal Pro-X carboxypeptidase precur... 212 1e-54
sp|Q5RBU7|PCP_PONPY Lysosomal Pro-X carboxypeptidase precur... 202 8e-52
sp|P42785|PCP_HUMAN Lysosomal Pro-X carboxypeptidase precur... 202 1e-51
sp|P34676|YO26_CAEEL Putative serine protease Z688.6 precursor 180 6e-45
sp|Q9EPB1|DPP2_RAT Dipeptidyl-peptidase II precursor (DPP I... 180 6e-45
sp|Q9UHL4|DPP2_HUMAN Dipeptidyl-peptidase II precursor (DPP... 178 2e-44
sp|Q9ET22|DPP2_MOUSE Dipeptidyl-peptidase II precursor (DPP... 174 4e-43
sp|P34610|PCP1_CAEEL Putative serine protease pcp-1 precursor 158 2e-38
sp|Q9NQE7|TSSP_HUMAN Thymus-specific serine protease precursor 90 8e-18
sp|Q9QXE5|TSSP_MOUSE Thymus-specific serine protease precursor 88 4e-17
>sp|Q7TMR0|PCP_MOUSE Lysosomal Pro-X carboxypeptidase precursor (Prolylcarboxypeptidase)
(PRCP) (Proline carboxypeptidase)
Length = 491
Score = 212 bits (539), Expect = 1e-54
Identities = 105/223 (47%), Positives = 149/223 (66%), Gaps = 2/223 (0%)
Frame = +3
Query: 186 QYETKYFPTYLDHFTYKNDSNKFLMKYLISTKNFV-DGNPILFYCGNEGSIELFANNSGF 362
+Y YF +DHF + D F +YL++ K++ +G ILFY GNEG I F NN+GF
Sbjct: 45 KYSVLYFEQKVDHFGFA-DMRTFKQRYLVADKHWQRNGGSILFYTGNEGDIVWFCNNTGF 103
Query: 363 VWELGEQLSAIVVFAEHRFYGSTLPFGKKSYDSAQYFGYLNSEQALADYADLLRHLKYNI 542
+W++ E+L A++VFAEHR+YG +LPFG+ S+ +Q+ +L SEQALAD+A+L+RHL+ I
Sbjct: 104 MWDVAEELKAMLVFAEHRYYGESLPFGQDSFKDSQHLNFLTSEQALADFAELIRHLEKTI 163
Query: 543 SGASHSPVIAFGGSYGGMLAAWFRQKYPNIVAGSLAASAPVLMVGNIENCSYPFQVLTKA 722
GA PVIA GGSYGGMLAAWFR KYP+IV G+LAASAP+ + + C +++T
Sbjct: 164 PGAQGQPVIAIGGSYGGMLAAWFRMKYPHIVVGALAASAPIWQLDGMVPCGEFMKIVTND 223
Query: 723 YQTKGSDACVSNVRNVWPVIQQMNDS-LHLVNLSRIFHTCQPL 848
++ K C ++R W VI +++ S L +L+ I H C PL
Sbjct: 224 FR-KSGPYCSESIRKSWNVIDKLSGSGSGLQSLTNILHLCSPL 265
>sp|Q5RBU7|PCP_PONPY Lysosomal Pro-X carboxypeptidase precursor (Prolylcarboxypeptidase)
(PRCP) (Proline carboxypeptidase)
Length = 496
Score = 202 bits (515), Expect = 8e-52
Identities = 101/226 (44%), Positives = 145/226 (64%), Gaps = 2/226 (0%)
Frame = +3
Query: 189 YETKYFPTYLDHFTYKNDSNKFLMKYLISTKNFV-DGNPILFYCGNEGSIELFANNSGFV 365
Y YF +DHF + N F +YL++ K + +G ILFY GNEG I F NN+GF+
Sbjct: 48 YSVLYFQQKVDHFGF-NTVKTFNQRYLVADKYWKKNGGSILFYTGNEGDIIWFCNNTGFM 106
Query: 366 WELGEQLSAIVVFAEHRFYGSTLPFGKKSYDSAQYFGYLNSEQALADYADLLRHLKYNIS 545
W++ E+L A++VFAEHR+YG +LPFG ++ +++ +L SEQALAD+A+L++HLK I
Sbjct: 107 WDVAEELKAMLVFAEHRYYGESLPFGDNTFKDSRHLNFLTSEQALADFAELIKHLKRTIP 166
Query: 546 GASHSPVIAFGGSYGGMLAAWFRQKYPNIVAGSLAASAPVLMVGNIENCSYPFQVLTKAY 725
GA + PVIA GGSYGGMLAAWFR KYP++V G+LAASAP+ ++ C +++T +
Sbjct: 167 GAENQPVIAIGGSYGGMLAAWFRMKYPHMVVGALAASAPIWQFEDLVPCGVFMKIVTTDF 226
Query: 726 QTKGSDACVSNVRNVWPVIQQM-NDSLHLVNLSRIFHTCQPLKNVD 860
+ G C ++R W I ++ N L L+ H C PL + D
Sbjct: 227 RKSGPH-CSESIRRSWDAINRLSNTGSGLQWLTGALHLCSPLTSQD 271
>sp|P42785|PCP_HUMAN Lysosomal Pro-X carboxypeptidase precursor (Prolylcarboxypeptidase)
(PRCP) (Proline carboxypeptidase) (Angiotensinase C)
(Lysosomal carboxypeptidase C)
Length = 496
Score = 202 bits (513), Expect = 1e-51
Identities = 101/226 (44%), Positives = 144/226 (63%), Gaps = 2/226 (0%)
Frame = +3
Query: 189 YETKYFPTYLDHFTYKNDSNKFLMKYLISTKNFV-DGNPILFYCGNEGSIELFANNSGFV 365
Y YF +DHF + N F +YL++ K + +G ILFY GNEG I F NN+GF+
Sbjct: 48 YSVLYFQQKVDHFGF-NTVKTFNQRYLVADKYWKKNGGSILFYTGNEGDIIWFCNNTGFM 106
Query: 366 WELGEQLSAIVVFAEHRFYGSTLPFGKKSYDSAQYFGYLNSEQALADYADLLRHLKYNIS 545
W++ E+L A++VFAEHR+YG +LPFG S+ +++ +L SEQALAD+A+L++HLK I
Sbjct: 107 WDVAEELKAMLVFAEHRYYGESLPFGDNSFKDSRHLNFLTSEQALADFAELIKHLKRTIP 166
Query: 546 GASHSPVIAFGGSYGGMLAAWFRQKYPNIVAGSLAASAPVLMVGNIENCSYPFQVLTKAY 725
GA + PVIA GGSYGGMLAAWFR KYP++V G+LAASAP+ ++ C +++T +
Sbjct: 167 GAENQPVIAIGGSYGGMLAAWFRMKYPHMVVGALAASAPIWQFEDLVPCGVFMKIVTTDF 226
Query: 726 QTKGSDACVSNVRNVWPVIQQM-NDSLHLVNLSRIFHTCQPLKNVD 860
+ G C ++ W I ++ N L L+ H C PL + D
Sbjct: 227 RKSGPH-CSESIHRSWDAINRLSNTGSGLQWLTGALHLCSPLTSQD 271
>sp|P34676|YO26_CAEEL Putative serine protease Z688.6 precursor
Length = 507
Score = 180 bits (456), Expect = 6e-45
Identities = 100/235 (42%), Positives = 143/235 (60%), Gaps = 6/235 (2%)
Frame = +3
Query: 180 EFQYETKYFPTYLDHFTYKNDSNKFLMKYLISTKNFVDGNPILFYCGNEGSIELFANNSG 359
+++YE Y +D F + ND +F ++Y ++ ++ G PILFY GNEGS+E FA N+G
Sbjct: 38 KYKYEEGYLKAPIDPFAFTNDL-EFDLRYFLNIDHYETGGPILFYTGNEGSLEAFAENTG 96
Query: 360 FVWELGEQLSAIVVFAEHRFYGSTLPFGKKSYDSAQYFGYLNSEQALADYADLLRHLK-Y 536
F+W+L +L A VVF EHRFYG + PF +SY ++ GYL+S+QALAD+A ++ K
Sbjct: 97 FMWDLAPELKAAVVFVEHRFYGKSQPFKNESYTDIRHLGYLSSQQALADFALSVQFFKNE 156
Query: 537 NISGASHSPVIAFGGSYGGMLAAWFRQKYPNIVAGSLAASAPVLMV--GNIENCSYPFQV 710
I GA S VIAFGGSYGGML+AWFR KYP+IV G++AASAPV NI Y F +
Sbjct: 157 KIKGAQKSAVIAFGGSYGGMLSAWFRIKYPHIVDGAIAASAPVFWFTDSNIPEDVYDF-I 215
Query: 711 LTKAYQTKGSDACVSNVRNVWPVIQQMNDSLHLVNLSRIFHTCQP---LKNVDDL 866
+T+A+ G + + W + ++ S + + P L+N DD+
Sbjct: 216 VTRAFLDAGCNR--KAIEKGWIALDELAKSDSGRQYLNVLYKLDPKSKLENKDDI 268
>sp|Q9EPB1|DPP2_RAT Dipeptidyl-peptidase II precursor (DPP II) (Dipeptidyl
aminopeptidase II) (Quiescent cell proline dipeptidase)
(Dipeptidyl peptidase 7)
Length = 500
Score = 180 bits (456), Expect = 6e-45
Identities = 106/234 (45%), Positives = 146/234 (62%), Gaps = 2/234 (0%)
Frame = +3
Query: 171 SNLEFQYETKYFPTYLDHFTYKNDSNK-FLMKYLISTKNFVDGN-PILFYCGNEGSIELF 344
S L+ + YF Y+DHF +++ SNK F ++L+S K + G PI FY GNEG I
Sbjct: 35 SVLDPDFRENYFEQYMDHFNFESFSNKTFGQRFLVSDKFWKMGEGPIFFYTGNEGDIWSL 94
Query: 345 ANNSGFVWELGEQLSAIVVFAEHRFYGSTLPFGKKSYDSAQYFGYLNSEQALADYADLLR 524
ANNSGF+ EL Q A++VFAEHR+YG +LPFG +S Y L EQALAD+A LL+
Sbjct: 95 ANNSGFIVELAAQQEALLVFAEHRYYGKSLPFGVQSTQRG-YTQLLTVEQALADFAVLLQ 153
Query: 525 HLKYNISGASHSPVIAFGGSYGGMLAAWFRQKYPNIVAGSLAASAPVLMVGNIENCSYPF 704
L++N+ G +P IAFGGSYGGML+A+ R KYP++VAG+LAASAPV+ V + N F
Sbjct: 154 ALRHNL-GVQDAPTIAFGGSYGGMLSAYMRMKYPHLVAGALAASAPVIAVAGLGNPDQFF 212
Query: 705 QVLTKAYQTKGSDACVSNVRNVWPVIQQMNDSLHLVNLSRIFHTCQPLKNVDDL 866
+ +T + + S C VR+ + I+ + +S+ F TCQ L + DL
Sbjct: 213 RDVTADFYGQ-SPKCAQAVRDAFQQIKDLFLQGAYDTISQNFGTCQSLSSPKDL 265
>sp|Q9UHL4|DPP2_HUMAN Dipeptidyl-peptidase II precursor (DPP II) (Dipeptidyl
aminopeptidase II) (Quiescent cell proline dipeptidase)
(Dipeptidyl peptidase 7)
Length = 492
Score = 178 bits (451), Expect = 2e-44
Identities = 102/228 (44%), Positives = 145/228 (63%), Gaps = 2/228 (0%)
Frame = +3
Query: 189 YETKYFPTYLDHFTYKNDSNK-FLMKYLISTKNFVDGN-PILFYCGNEGSIELFANNSGF 362
++ ++F LDHF ++ NK F ++L+S + +V G PI FY GNEG + FANNSGF
Sbjct: 31 FQERFFQQRLDHFNFERFGNKTFPQRFLVSDRFWVRGEGPIFFYTGNEGDVWAFANNSGF 90
Query: 363 VWELGEQLSAIVVFAEHRFYGSTLPFGKKSYDSAQYFGYLNSEQALADYADLLRHLKYNI 542
V EL + A++VFAEHR+YG +LPFG +S + L EQALAD+A+LLR L+ ++
Sbjct: 91 VAELAAERGALLVFAEHRYYGKSLPFGAQSTQRG-HTELLTVEQALADFAELLRALRRDL 149
Query: 543 SGASHSPVIAFGGSYGGMLAAWFRQKYPNIVAGSLAASAPVLMVGNIENCSYPFQVLTKA 722
GA +P IAFGGSYGGML+A+ R KYP++VAG+LAASAPVL V + + + F+ +T
Sbjct: 150 -GAQDAPAIAFGGSYGGMLSAYLRMKYPHLVAGALAASAPVLAVAGLGDSNQFFRDVTAD 208
Query: 723 YQTKGSDACVSNVRNVWPVIQQMNDSLHLVNLSRIFHTCQPLKNVDDL 866
++ + S C VR + I+ + + F TCQPL + DL
Sbjct: 209 FEGQ-SPKCTQGVREAFRQIKDLFLQGAYDTVRWEFGTCQPLSDEKDL 255
>sp|Q9ET22|DPP2_MOUSE Dipeptidyl-peptidase II precursor (DPP II) (Dipeptidyl
aminopeptidase II) (Quiescent cell proline dipeptidase)
(Dipeptidyl peptidase 7)
Length = 506
Score = 174 bits (440), Expect = 4e-43
Identities = 103/232 (44%), Positives = 144/232 (62%), Gaps = 2/232 (0%)
Frame = +3
Query: 177 LEFQYETKYFPTYLDHFTYKNDSNK-FLMKYLISTKNFVDGN-PILFYCGNEGSIELFAN 350
L+ + YF Y+DHF +++ NK F ++L+S K + G PI FY GNEG I FAN
Sbjct: 37 LDPDFHENYFEQYMDHFNFESFGNKTFGQRFLVSDKFWKMGEGPIFFYTGNEGDIWSFAN 96
Query: 351 NSGFVWELGEQLSAIVVFAEHRFYGSTLPFGKKSYDSAQYFGYLNSEQALADYADLLRHL 530
NSGF+ EL Q A++VFAEHR+YG +LPFG +S Y L EQALAD+A LL+ L
Sbjct: 97 NSGFMVELAAQQEALLVFAEHRYYGKSLPFGVQSTQRG-YTQLLTVEQALADFAVLLQAL 155
Query: 531 KYNISGASHSPVIAFGGSYGGMLAAWFRQKYPNIVAGSLAASAPVLMVGNIENCSYPFQV 710
+ ++ G +P IAFGGSYGGML+A+ R KYP++VAG+LAASAPV+ V + + F+
Sbjct: 156 RQDL-GVHDAPTIAFGGSYGGMLSAYMRMKYPHLVAGALAASAPVVAVAGLGDSYQFFRD 214
Query: 711 LTKAYQTKGSDACVSNVRNVWPVIQQMNDSLHLVNLSRIFHTCQPLKNVDDL 866
+T + + S C VR+ + I+ + +S+ F TCQ L + DL
Sbjct: 215 VTADFYGQ-SPKCAQAVRDAFQQIKDLFLQGAYDTISQNFGTCQSLSSPKDL 265
>sp|P34610|PCP1_CAEEL Putative serine protease pcp-1 precursor
Length = 565
Score = 158 bits (400), Expect = 2e-38
Identities = 84/193 (43%), Positives = 122/193 (63%), Gaps = 7/193 (3%)
Frame = +3
Query: 216 LDHFTYKNDSNKFLMKYLISTKNFVDGNPILFYCGNEGSIELFANNSGFVWELGEQLSAI 395
LDHFT+ D+ F M+ + + + G PI FY GNEG +E F +G +++L +A
Sbjct: 51 LDHFTW-GDTRTFDMRVMWNNTFYKPGGPIFFYTGNEGGLESFVTATGMMFDLAPMFNAS 109
Query: 396 VVFAEHRFYGSTLPFGKKSYDSAQYFGYLNSEQALADYADLLRHLK-----YNISGASHS 560
++FAEHRFYG T PFG +SY S GYL SEQALADYA+LL LK + ++ + +
Sbjct: 110 IIFAEHRFYGQTQPFGNQSYASLANVGYLTSEQALADYAELLTELKRDNNQFKMTFPAAT 169
Query: 561 PVIAFGGSYGGMLAAWFRQKYPNIVAGSLAASAPVLMV--GNIENCSYPFQVLTKAYQTK 734
VI+FGGSYGGML+AWFRQKYP+IV G+ A SAP++ + G ++ ++ + ++ Y
Sbjct: 170 QVISFGGSYGGMLSAWFRQKYPHIVKGAWAGSAPLIYMNGGGVDPGAFD-HITSRTYIDN 228
Query: 735 GSDACVSNVRNVW 773
G + + + N W
Sbjct: 229 GCNRFI--LANAW 239
>sp|Q9NQE7|TSSP_HUMAN Thymus-specific serine protease precursor
Length = 514
Score = 90.1 bits (222), Expect = 8e-18
Identities = 61/155 (39%), Positives = 86/155 (55%), Gaps = 2/155 (1%)
Frame = +3
Query: 216 LDHFTYKNDSNKFLMKYLISTKNFV--DGNPILFYCGNEGSIELFANNSGFVWELGEQLS 389
LD F +D FL +Y ++ +++V DG PI + G EGS+ + G L
Sbjct: 66 LDPFNV-SDRRSFLQRYWVNDQHWVGQDG-PIFLHLGGEGSLGPGSVMRGHPAALAPAWG 123
Query: 390 AIVVFAEHRFYGSTLPFGKKSYDSAQYFGYLNSEQALADYADLLRHLKYNISGASHSPVI 569
A+V+ EHRFYG ++P G + AQ +L+S ALAD L + +S SP I
Sbjct: 124 ALVISLEHRFYGLSIPAG--GLEMAQ-LRFLSSRLALADVVSARLALSRLFNISSSSPWI 180
Query: 570 AFGGSYGGMLAAWFRQKYPNIVAGSLAASAPVLMV 674
FGGSY G LAAW R K+P+++ S+A+SAPV V
Sbjct: 181 CFGGSYAGSLAAWARLKFPHLIFASVASSAPVRAV 215
>sp|Q9QXE5|TSSP_MOUSE Thymus-specific serine protease precursor
Length = 509
Score = 87.8 bits (216), Expect = 4e-17
Identities = 57/154 (37%), Positives = 85/154 (55%), Gaps = 1/154 (0%)
Frame = +3
Query: 216 LDHFTYKNDSNKFLMKYLISTKNFVDGN-PILFYCGNEGSIELFANNSGFVWELGEQLSA 392
LD F +D FL +Y ++ ++ + P+ + G EGS+ + +G L A
Sbjct: 65 LDPFN-ASDRRTFLQRYWVNDQHRTGQDVPVFLHIGGEGSLGPGSVMAGHPAALAPAWGA 123
Query: 393 IVVFAEHRFYGSTLPFGKKSYDSAQYFGYLNSEQALADYADLLRHLKYNISGASHSPVIA 572
+V+ EHRFYG ++P G D A YL+S ALAD A + L ++ +S SP I
Sbjct: 124 LVISLEHRFYGLSMPAG--GLDLA-LLRYLSSRHALADVASARQALSGLLNVSSSSPWIC 180
Query: 573 FGGSYGGMLAAWFRQKYPNIVAGSLAASAPVLMV 674
FGGSY G LA W R K+P++V ++A+SAP+ V
Sbjct: 181 FGGSYAGSLATWARLKFPHLVFAAVASSAPLSAV 214
Database: Non-redundant SwissProt sequences
Posted date: Dec 6, 2005 7:40 AM
Number of letters in database: 68,354,980
Number of sequences in database: 184,735
Database: swissprot.01
Posted date: Dec 6, 2005 8:18 AM
Number of letters in database: 66,202,850
Number of sequences in database: 184,431
Lambda K H
0.318 0.134 0.401
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 95,222,549
Number of Sequences: 369166
Number of extensions: 1912318
Number of successful extensions: 5126
Number of sequences better than 10.0: 10
Number of HSP's better than 10.0 without gapping: 4961
Number of HSP's successfully gapped in prelim test: 0
Number of HSP's that attempted gapping in prelim test: 0
Number of HSP's gapped (non-prelim): 5106
length of database: 68,354,980
effective HSP length: 110
effective length of database: 48,034,130
effective search space used: 9174518830
frameshift window, decay const: 40, 0.1
T: 12
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)