Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= Dr_sW_005_F05
(874 letters)
Database: Non-redundant SwissProt sequences
184,735 sequences; 68,354,980 total letters
Score E
Sequences producing significant alignments: (bits) Value
sp|Q9JHI0|MMP19_MOUSE Matrix metalloproteinase-19 precursor... 114 3e-25
sp|P79287|MMP20_PIG Matrix metalloproteinase-20 precursor (... 113 6e-25
sp|O18767|MMP20_BOVIN Matrix metalloproteinase-20 precursor... 113 8e-25
sp|O60882|MMP20_HUMAN Matrix metalloproteinase-20 precursor... 112 1e-24
sp|P57748|MMP20_MOUSE Matrix metalloproteinase-20 precursor... 109 9e-24
sp|O62806|MMP13_RABIT Collagenase 3 precursor (Matrix metal... 108 1e-23
sp|P33435|MMP13_MOUSE Collagenase 3 precursor (Matrix metal... 108 2e-23
sp|O77656|MMP13_BOVIN Collagenase 3 precursor (Matrix metal... 108 3e-23
sp|P22757|HE_PARLI Hatching enzyme precursor (HE) (HEZ) (En... 107 6e-23
sp|O18927|MMP13_HORSE Collagenase 3 precursor (Matrix metal... 107 6e-23
>sp|Q9JHI0|MMP19_MOUSE Matrix metalloproteinase-19 precursor (MMP-19) (Matrix
metalloproteinase RASI)
Length = 527
Score = 114 bits (286), Expect = 3e-25
Identities = 88/282 (31%), Positives = 127/282 (45%), Gaps = 15/282 (5%)
Frame = +1
Query: 1 KGTTYRFYIHDERHPTTMTLGEIQRALMIGLSYWSTAGDIYFAKVSNKQGSMFSLSFADA 180
K T+R + P+T++L ++ AL YWS+ + F +V + LSF
Sbjct: 108 KNLTFRIF----NVPSTLSLPRVRAALHQAFKYWSSVAPLTFREVKAGWADI-RLSFHGR 162
Query: 181 EHVQYDVHNNFVESRDPYPLDNVPGGVLAHAFFPRNGNLHFDSAEEWTEGKEDGINLRLV 360
+ + N F + PG VLAHA P G++HFD E WTEG G+NLR++
Sbjct: 163 QSLYCS--NTF----------DGPGKVLAHADIPELGSIHFDKDELWTEGTYQGVNLRII 210
Query: 361 AAHEMGHAIGLFHSNDPNALMAPWYGGYISENDFKLPDDDSQGAAFIYGTKN-------- 516
AAHE+GHA+GL HS ALMAP Y GY + FKL DD G +YG ++
Sbjct: 211 AAHEVGHALGLGHSRYTQALMAPVYAGY--QPFFKLHPDDVAGIQALYGKRSPETRDEEE 268
Query: 517 -------GKVFVRSNKKREQSANEKELCNITNINSAFQYSDDNIYVVTDKNKVFRIIHSN 675
V + + E + + + + D ++ VTD
Sbjct: 269 ETEMLTVSPVTAKPGPMPNPCSGEVDAMVLGPRGKTYAFKGDYVWTVTDSG-------PG 321
Query: 676 NSFRVDASFKTLQLPNQLFDSDALFYDYSGRRFVFFKGNRVF 801
F++ A ++ LP L DA Y RR FFKGN+V+
Sbjct: 322 PLFQISALWE--GLPGNL---DAAVYSPRTRRTHFFKGNKVW 358
>sp|P79287|MMP20_PIG Matrix metalloproteinase-20 precursor (MMP-20) (Enamel
metalloproteinase) (Enamelysin)
Length = 483
Score = 113 bits (283), Expect = 6e-25
Identities = 89/278 (32%), Positives = 129/278 (46%), Gaps = 6/278 (2%)
Frame = +1
Query: 10 TYRFYIHDERHPTTMTLGEIQRALMIGLSYWSTAGDIYFAKVSNKQGSMFSLSFADAEHV 189
TYR ++ +MT E+ +A+ + L WS+A + F +V+ + + +SF +H
Sbjct: 123 TYRI----SKYTPSMTPAEVDKAMEMALQAWSSAVPLSFVRVNAGEADIM-ISFETGDH- 176
Query: 190 QYDVHNNFVESRDPYPLDNVPGGVLAHAFFPRNG---NLHFDSAEEWTEGKEDGINLRLV 360
D YP D P G LAHAF P G + HFD+AE+WT G +G NL V
Sbjct: 177 -----------GDSYPFDG-PRGTLAHAFAPGEGLGGDTHFDNAEKWTMGM-NGFNLFTV 223
Query: 361 AAHEMGHAIGLFHSNDPNALMAPWYGGYISENDFKLPDDDSQGAAFIYG---TKNGKVFV 531
AAHE GHA+GL HS DP+ALM P Y Y + F LP DD +G +YG T GK V
Sbjct: 224 AAHEFGHALGLAHSTDPSALMYPTY-KYQNPYGFHLPKDDVKGIQALYGPRKTFTGKPTV 282
Query: 532 RSNKKREQSANEKELCNITNINSAFQYSDDNIYVVTDKNKVFRIIHSNNSFRVDASFKTL 711
S ++C+ ++ A + D+ R +H + R S T
Sbjct: 283 PHGPPHNPSL--PDICDSSSSFDAVTMLGKELLFFRDRIFWRRQVHLMSGIR--PSTITS 338
Query: 712 QLPNQLFDSDALFYDYSGRRFVFFKGNRVFSANGVKLE 825
P + + DA + FFKG + G +++
Sbjct: 339 SFPQLMSNVDAAYEVADRGMAYFFKGPHYWITRGFQMQ 376
>sp|O18767|MMP20_BOVIN Matrix metalloproteinase-20 precursor (MMP-20) (Enamel
metalloproteinase) (Enamelysin)
Length = 481
Score = 113 bits (282), Expect = 8e-25
Identities = 88/278 (31%), Positives = 129/278 (46%), Gaps = 6/278 (2%)
Frame = +1
Query: 10 TYRFYIHDERHPTTMTLGEIQRALMIGLSYWSTAGDIYFAKVSNKQGSMFSLSFADAEHV 189
TYR ++ +MT E+ RA+ + L WS+A + F +++ + + +SF +H
Sbjct: 121 TYRI----SKYTPSMTPAEVDRAMEMALRAWSSAVPLNFVRINAGEADIM-ISFETGDH- 174
Query: 190 QYDVHNNFVESRDPYPLDNVPGGVLAHAFFPRNG---NLHFDSAEEWTEGKEDGINLRLV 360
D YP D P G LAHAF P G + HFD+AE+WT G +G NL V
Sbjct: 175 -----------GDSYPFDG-PRGTLAHAFAPGEGLGGDTHFDNAEKWTMGT-NGFNLFTV 221
Query: 361 AAHEMGHAIGLFHSNDPNALMAPWYGGYISENDFKLPDDDSQGAAFIYGTK---NGKVFV 531
AAHE GHA+GL HS DP+ALM P Y Y + F+LP DD +G +YG + +GK
Sbjct: 222 AAHEFGHALGLAHSTDPSALMFPTY-KYQNPYGFRLPKDDVKGIQALYGPRRAFSGKPTA 280
Query: 532 RSNKKREQSANEKELCNITNINSAFQYSDDNIYVVTDKNKVFRIIHSNNSFRVDASFKTL 711
S +LC+ A + + D+ R +H + R S T
Sbjct: 281 PHGPPHNPSI--PDLCDSNLSFDAVTMLGKELLLFRDRIFWRRQVHLMSGIR--PSTITS 336
Query: 712 QLPNQLFDSDALFYDYSGRRFVFFKGNRVFSANGVKLE 825
P + + DA + FFKG + G +++
Sbjct: 337 SFPQLMSNVDAAYEVAERGTAYFFKGPHYWITRGFQMQ 374
>sp|O60882|MMP20_HUMAN Matrix metalloproteinase-20 precursor (MMP-20) (Enamel
metalloproteinase) (Enamelysin)
Length = 483
Score = 112 bits (281), Expect = 1e-24
Identities = 86/278 (30%), Positives = 132/278 (47%), Gaps = 6/278 (2%)
Frame = +1
Query: 10 TYRFYIHDERHPTTMTLGEIQRALMIGLSYWSTAGDIYFAKVSNKQGSMFSLSFADAEHV 189
TYR ++ +M+ E+ +A+ + L WS+A + F ++++ + + +SF + +H
Sbjct: 123 TYRI----SKYTPSMSSVEVDKAVEMALQAWSSAVPLSFVRINSGEADIM-ISFENGDH- 176
Query: 190 QYDVHNNFVESRDPYPLDNVPGGVLAHAFFPRNG---NLHFDSAEEWTEGKEDGINLRLV 360
D YP D P G LAHAF P G + HFD+AE+WT G +G NL V
Sbjct: 177 -----------GDSYPFDG-PRGTLAHAFAPGEGLGGDTHFDNAEKWTMGT-NGFNLFTV 223
Query: 361 AAHEMGHAIGLFHSNDPNALMAPWYGGYISENDFKLPDDDSQGAAFIYGTKNGKVFVRS- 537
AAHE GHA+GL HS DP+ALM P Y Y + F LP DD +G +YG + KVF+
Sbjct: 224 AAHEFGHALGLAHSTDPSALMYPTY-KYKNPYGFHLPKDDVKGIQALYGPR--KVFLGKP 280
Query: 538 --NKKREQSANEKELCNITNINSAFQYSDDNIYVVTDKNKVFRIIHSNNSFRVDASFKTL 711
+ +LC+ ++ A + + D+ R +H R S T
Sbjct: 281 TLPHAPHHKPSIPDLCDSSSSFDAVTMLGKELLLFKDRIFWRRQVHLRTGIR--PSTITS 338
Query: 712 QLPNQLFDSDALFYDYSGRRFVFFKGNRVFSANGVKLE 825
P + + DA + FFKG + G +++
Sbjct: 339 SFPQLMSNVDAAYEVAERGTAYFFKGPHYWITRGFQMQ 376
>sp|P57748|MMP20_MOUSE Matrix metalloproteinase-20 precursor (MMP-20) (Enamel
metalloproteinase) (Enamelysin)
Length = 482
Score = 109 bits (273), Expect = 9e-24
Identities = 87/278 (31%), Positives = 129/278 (46%), Gaps = 6/278 (2%)
Frame = +1
Query: 10 TYRFYIHDERHPTTMTLGEIQRALMIGLSYWSTAGDIYFAKVSNKQGSMFSLSFADAEHV 189
TYR ++ +M+ E+ +A+ + L WSTA + F ++++ + + +SF +H
Sbjct: 122 TYRI----SKYTPSMSPTEVDKAIQMALHAWSTAVPLNFVRINSGEADIM-ISFETGDH- 175
Query: 190 QYDVHNNFVESRDPYPLDNVPGGVLAHAFFPRNG---NLHFDSAEEWTEGKEDGINLRLV 360
D YP D P G LAHAF P G + HFD+AE+WT G +G NL V
Sbjct: 176 -----------GDSYPFDG-PRGTLAHAFAPGEGLGGDTHFDNAEKWTMGT-NGFNLFTV 222
Query: 361 AAHEMGHAIGLFHSNDPNALMAPWYGGYISENDFKLPDDDSQGAAFIYGTKN---GKVFV 531
AAHE GHA+GL HS DP+ALM P Y Y + F LP DD +G +YG + GK +
Sbjct: 223 AAHEFGHALGLGHSTDPSALMYPTY-KYQNPYRFHLPKDDVKGIQALYGPRKIFPGKPTM 281
Query: 532 RSNKKREQSANEKELCNITNINSAFQYSDDNIYVVTDKNKVFRIIHSNNSFRVDASFKTL 711
+ S +LC+ ++ A + D+ R +H R S T
Sbjct: 282 PHIPPHKPSI--PDLCDSSSSFDAVTMLGKELLFFKDRIFWRRQVHLPTGIR--PSTITS 337
Query: 712 QLPNQLFDSDALFYDYSGRRFVFFKGNRVFSANGVKLE 825
P + + DA + FFKG + G ++
Sbjct: 338 SFPQLMSNVDAAYEVAERGIAFFFKGPHYWVTRGFHMQ 375
>sp|O62806|MMP13_RABIT Collagenase 3 precursor (Matrix metalloproteinase-13) (MMP-13)
Length = 471
Score = 108 bits (271), Expect = 1e-23
Identities = 82/258 (31%), Positives = 119/258 (46%), Gaps = 4/258 (1%)
Frame = +1
Query: 52 MTLGEIQRALMIGLSYWSTAGDIYFAKVSNKQGSMFSLSFADAEHVQYDVHNNFVESRDP 231
+T E+++A WS + F ++ N + +SF EH +
Sbjct: 129 LTHSEVEKAFKKAFKVWSDVTPLNFTRIHNGTADIM-ISFGTKEHGDF------------ 175
Query: 232 YPLDNVPGGVLAHAFFPR---NGNLHFDSAEEWTEGKEDGINLRLVAAHEMGHAIGLFHS 402
YP D P G+LAHAF P G+ HFD E WT + G NL LVAAHE GH++GL HS
Sbjct: 176 YPFDG-PSGLLAHAFPPGPNYGGDAHFDDDETWTSSSK-GYNLFLVAAHEFGHSLGLDHS 233
Query: 403 NDPNALMAPWYGGYISENDFKLPDDDSQGAAFIYGTKNGKVFVRSNKKREQSANEKELCN 582
DP ALM P Y Y ++ F LPDDD QG +YG + + K ++ L
Sbjct: 234 KDPGALMFPIY-TYTGKSHFMLPDDDVQGIQSLYGPGDEDPNPKHPKTPDKCDPSLSLDA 292
Query: 583 ITNINSAFQYSDDNIYVVTDKNKVFRIIHSNNSFRVDASFKTLQLPNQLFDSDALFYDYS 762
IT++ D + +V + SF +LPN++ DA Y++
Sbjct: 293 ITSLRGETMIFKDRFFWRLHPQQVDAELFLTKSF-------WPELPNRI---DAA-YEHP 341
Query: 763 GRRFVF-FKGNRVFSANG 813
R +F F+G + ++ NG
Sbjct: 342 ARDLIFIFRGKKFWAPNG 359
>sp|P33435|MMP13_MOUSE Collagenase 3 precursor (Matrix metalloproteinase-13) (MMP-13)
Length = 472
Score = 108 bits (270), Expect = 2e-23
Identities = 82/258 (31%), Positives = 120/258 (46%), Gaps = 4/258 (1%)
Frame = +1
Query: 52 MTLGEIQRALMIGLSYWSTAGDIYFAKVSNKQGSMFSLSFADAEHVQYDVHNNFVESRDP 231
M+ E+++A WS + F ++ + + +SF EH +
Sbjct: 130 MSHSEVEKAFRKAFKVWSDVTPLNFTRIYDGTADIM-ISFGTKEHGDF------------ 176
Query: 232 YPLDNVPGGVLAHAFFPR---NGNLHFDSAEEWTEGKEDGINLRLVAAHEMGHAIGLFHS 402
YP D P G+LAHAF P G+ HFD E WT + G NL +VAAHE+GH++GL HS
Sbjct: 177 YPFDG-PSGLLAHAFPPGPNYGGDAHFDDDETWTSSSK-GYNLFIVAAHELGHSLGLDHS 234
Query: 403 NDPNALMAPWYGGYISENDFKLPDDDSQGAAFIYGTKNGKVFVRSNKKREQSANEKELCN 582
DP ALM P Y Y ++ F LPDDD QG F+YG + + K E+ L
Sbjct: 235 KDPGALMFPIY-TYTGKSHFMLPDDDVQGIQFLYGPGDEDPNPKHPKTPEKCDPALSLDA 293
Query: 583 ITNINSAFQYSDDNIYVVTDKNKVFRIIHSNNSFRVDASFKTLQLPNQLFDSDALFYDYS 762
IT++ D + +V + SF +LPN + DA Y++
Sbjct: 294 ITSLRGETMIFKDRFFWRLHPQQVEAELFLTKSF-------WPELPNHV---DAA-YEHP 342
Query: 763 GRRFVF-FKGNRVFSANG 813
R +F F+G + ++ NG
Sbjct: 343 SRDLMFIFRGRKFWALNG 360
>sp|O77656|MMP13_BOVIN Collagenase 3 precursor (Matrix metalloproteinase-13) (MMP-13)
Length = 471
Score = 108 bits (269), Expect = 3e-23
Identities = 81/269 (30%), Positives = 118/269 (43%), Gaps = 9/269 (3%)
Frame = +1
Query: 52 MTLGEIQRALMIGLSYWSTAGDIYFAKVSNKQGSMFSLSFADAEHVQYDVHNNFVESRDP 231
+T E+++A WS + F ++ N + +SF EH +
Sbjct: 129 LTHSEVEKAFRKAFKVWSDVTPLNFTRIHNGTADIM-ISFGTKEHGDF------------ 175
Query: 232 YPLDNVPGGVLAHAFFPR---NGNLHFDSAEEWTEGKEDGINLRLVAAHEMGHAIGLFHS 402
YP D P G+LAHAF P G+ HFD E WT + G NL LVAAHE GH++GL HS
Sbjct: 176 YPFDG-PSGLLAHAFPPGPNYGGDAHFDDDETWTSSSK-GYNLFLVAAHEFGHSLGLDHS 233
Query: 403 NDPNALMAPWYGGYISENDFKLPDDDSQGAAFIYGTKNGKVFVRSNKKREQSANEKELCN 582
DP ALM P Y Y ++ F LPDDD QG +YG + + + K ++ L
Sbjct: 234 KDPGALMFPIY-TYTGKSHFMLPDDDVQGIQSLYGPGDEDPYSKHPKTPDKCDPSLSLDA 292
Query: 583 ITNINSAFQYSDDNIYVVTDKNKVFRIIHSNNSF------RVDASFKTLQLPNQLFDSDA 744
IT++ D + +V + SF R+DA+++ S
Sbjct: 293 ITSLRGETLIFKDRFFWRLHPQQVEAELFLTKSFGPELPNRIDAAYE--------HPSHD 344
Query: 745 LFYDYSGRRFVFFKGNRVFSANGVKLENL 831
L + + GR+F G + K+ L
Sbjct: 345 LIFIFRGRKFWALSGYDILEDYPKKISEL 373
>sp|P22757|HE_PARLI Hatching enzyme precursor (HE) (HEZ) (Envelysin)
(Sea-urchin-hatching proteinase) [Contains: Hatching
enzyme 18 kDa form]
Length = 587
Score = 107 bits (266), Expect = 6e-23
Identities = 60/152 (39%), Positives = 81/152 (53%)
Frame = +1
Query: 64 EIQRALMIGLSYWSTAGDIYFAKVSNKQGSMFSLSFADAEHVQYDVHNNFVESRDPYPLD 243
EI+RA + W + F +V + + F +H D D
Sbjct: 199 EIRRAFRV----WDDVSGLSFREVPDTTSVDIRIKFGSYDH------------GDGISFD 242
Query: 244 NVPGGVLAHAFFPRNGNLHFDSAEEWTEGKEDGINLRLVAAHEMGHAIGLFHSNDPNALM 423
GGVLAHAF PRNG+ HFD +E WTEG G NL VAAHE GH++GL+HS +ALM
Sbjct: 243 G-RGGVLAHAFLPRNGDAHFDDSETWTEGTRSGTNLFQVAAHEFGHSLGLYHSTVRSALM 301
Query: 424 APWYGGYISENDFKLPDDDSQGAAFIYGTKNG 519
P+Y GY+ +F+L +DD G +YG+ +G
Sbjct: 302 YPYYQGYVP--NFRLDNDDIAGIRSLYGSNSG 331
>sp|O18927|MMP13_HORSE Collagenase 3 precursor (Matrix metalloproteinase-13) (MMP-13)
Length = 472
Score = 107 bits (266), Expect = 6e-23
Identities = 81/258 (31%), Positives = 119/258 (46%), Gaps = 4/258 (1%)
Frame = +1
Query: 52 MTLGEIQRALMIGLSYWSTAGDIYFAKVSNKQGSMFSLSFADAEHVQYDVHNNFVESRDP 231
+T E+++A WS + F ++ N + +SF EH +
Sbjct: 130 LTHSEVEKAFKKAFKVWSDVTPLNFTRLYNGTADIM-ISFGTKEHGDF------------ 176
Query: 232 YPLDNVPGGVLAHAFFPR---NGNLHFDSAEEWTEGKEDGINLRLVAAHEMGHAIGLFHS 402
YP D P G+LAHAF P G+ HFD E WT + G NL LVAAHE GH++GL HS
Sbjct: 177 YPFDG-PSGLLAHAFPPGPNYGGDAHFDDDETWTSSSK-GYNLFLVAAHEFGHSLGLDHS 234
Query: 403 NDPNALMAPWYGGYISENDFKLPDDDSQGAAFIYGTKNGKVFVRSNKKREQSANEKELCN 582
DP ALM P Y Y ++ F LPDDD QG ++YG + + K ++ L
Sbjct: 235 KDPGALMFPIY-TYTGKSHFVLPDDDVQGIQYLYGPGDEDPNPKHPKTPDKCDPSLSLDA 293
Query: 583 ITNINSAFQYSDDNIYVVTDKNKVFRIIHSNNSFRVDASFKTLQLPNQLFDSDALFYDYS 762
IT++ D + V + SF +LPN++ DA Y++
Sbjct: 294 ITSLRGETMVFKDRFFWRLHPQLVDAELFLTKSF-------WPELPNRI---DAA-YEHP 342
Query: 763 GRRFVF-FKGNRVFSANG 813
+ +F F+G + ++ NG
Sbjct: 343 SKDLIFIFRGRKFWALNG 360
Database: Non-redundant SwissProt sequences
Posted date: Dec 6, 2005 7:40 AM
Number of letters in database: 68,354,980
Number of sequences in database: 184,735
Database: swissprot.01
Posted date: Dec 6, 2005 8:18 AM
Number of letters in database: 66,202,850
Number of sequences in database: 184,431
Lambda K H
0.318 0.134 0.401
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 99,339,449
Number of Sequences: 369166
Number of extensions: 2054404
Number of successful extensions: 6264
Number of sequences better than 10.0: 10
Number of HSP's better than 10.0 without gapping: 5797
Number of HSP's successfully gapped in prelim test: 0
Number of HSP's that attempted gapping in prelim test: 0
Number of HSP's gapped (non-prelim): 6107
length of database: 68,354,980
effective HSP length: 110
effective length of database: 48,034,130
effective search space used: 8646143400
frameshift window, decay const: 40, 0.1
T: 12
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)