Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= Dr_sW_004_P22
(827 letters)
Database: Non-redundant SwissProt sequences
184,735 sequences; 68,354,980 total letters
Score E
Sequences producing significant alignments: (bits) Value
sp|Q7TMR0|PCP_MOUSE Lysosomal Pro-X carboxypeptidase precur... 189 1e-47
sp|Q5RBU7|PCP_PONPY Lysosomal Pro-X carboxypeptidase precur... 185 2e-46
sp|P42785|PCP_HUMAN Lysosomal Pro-X carboxypeptidase precur... 183 4e-46
sp|Q9UHL4|DPP2_HUMAN Dipeptidyl-peptidase II precursor (DPP... 149 1e-35
sp|Q9ET22|DPP2_MOUSE Dipeptidyl-peptidase II precursor (DPP... 148 2e-35
sp|Q9EPB1|DPP2_RAT Dipeptidyl-peptidase II precursor (DPP I... 145 1e-34
sp|P34676|YO26_CAEEL Putative serine protease Z688.6 precursor 134 2e-31
sp|P34610|PCP1_CAEEL Putative serine protease pcp-1 precursor 94 3e-19
sp|Q9NQE7|TSSP_HUMAN Thymus-specific serine protease precursor 50 6e-06
sp|P34528|YM67_CAEEL Putative serine protease K12H4.7 precu... 49 2e-05
>sp|Q7TMR0|PCP_MOUSE Lysosomal Pro-X carboxypeptidase precursor (Prolylcarboxypeptidase)
(PRCP) (Proline carboxypeptidase)
Length = 491
Score = 189 bits (479), Expect = 1e-47
Identities = 95/245 (38%), Positives = 138/245 (56%), Gaps = 4/245 (1%)
Frame = +3
Query: 45 KGSDACVSNVRNVWPVIQQMNDS-LHLVNLSRIFHTCQPL--KNVDDLIAVLTDGLFDMG 215
K C ++R W VI +++ S L +L+ I H C PL + + L + + ++
Sbjct: 226 KSGPYCSESIRKSWNVIDKLSGSGSGLQSLTNILHLCSPLTSEKIPTLKGWIAETWVNLA 285
Query: 216 MANYPYPANFLGPMPAWPVKEFCKPLSNLIKDPIELLNAFFTGLQVFYNYTGQIQCLSTT 395
M NYPY NFL P+PAWP+KE C+ L N LL F L V+YNY+GQ CL+ +
Sbjct: 286 MVNYPYACNFLQPLPAWPIKEVCQYLKNPNVSDTVLLQNIFQALSVYYNYSGQAACLNIS 345
Query: 396 -TNLPGLDDNGWNVQTCTELPMPMCTDGVKDMFYASSFNKQNNDRSCQKSFGVTPRWGWG 572
T L GW+ Q CTE+ MP CT+G+ DMF ++ + C +GV PR W
Sbjct: 346 QTTTSSLGSMGWSFQACTEMVMPFCTNGIDDMFEPFLWDLEKYSNDCFNQWGVKPRPHWM 405
Query: 573 QTLFWGKNLNAASNIIFSNGLLDPWAAGGVFNSPNPSIEIVTMKNGAHHVDLRSSHPKDT 752
T++ GKN+++ SNIIFSNG LDPW+ GGV ++ + + +GAHH+DLR+ + D
Sbjct: 406 TTMYGGKNISSHSNIIFSNGELDPWSGGGVTRDITDTLVAINIHDGAHHLDLRAHNAFDP 465
Query: 753 YDIRL 767
+ L
Sbjct: 466 SSVLL 470
>sp|Q5RBU7|PCP_PONPY Lysosomal Pro-X carboxypeptidase precursor (Prolylcarboxypeptidase)
(PRCP) (Proline carboxypeptidase)
Length = 496
Score = 185 bits (469), Expect = 2e-46
Identities = 94/245 (38%), Positives = 140/245 (57%), Gaps = 4/245 (1%)
Frame = +3
Query: 45 KGSDACVSNVRNVWPVIQQM-NDSLHLVNLSRIFHTCQPL--KNVDDLIAVLTDGLFDMG 215
K C ++R W I ++ N L L+ H C PL +++ L +++ ++
Sbjct: 228 KSGPHCSESIRRSWDAINRLSNTGSGLQWLTGALHLCSPLTSQDIQHLKDWISETWVNLA 287
Query: 216 MANYPYPANFLGPMPAWPVKEFCKPLSNLIKDPIELLNAFFTGLQVFYNYTGQIQCLSTT 395
M +YPY +NFL P+PAWP+K C+ L N LL F L V+YNY+GQ++CL+ +
Sbjct: 288 MVDYPYASNFLQPLPAWPIKVVCQYLKNPNVSDSLLLQNIFQALNVYYNYSGQVKCLNIS 347
Query: 396 -TNLPGLDDNGWNVQTCTELPMPMCTDGVKDMFYASSFNKQNNDRSCQKSFGVTPRWGWG 572
T L GW+ Q CTE+ MP CT+GV DMF S+N + C + +GV PR W
Sbjct: 348 ETATSSLGTLGWSYQACTEVVMPFCTNGVDDMFEPHSWNLKELSDDCFQQWGVRPRPSWI 407
Query: 573 QTLFWGKNLNAASNIIFSNGLLDPWAAGGVFNSPNPSIEIVTMKNGAHHVDLRSSHPKDT 752
T++ GKN+++ +NI+FSNG LDPW+ GGV ++ VT+ GAHH+DLR+ + D
Sbjct: 408 TTMYGGKNISSHTNIVFSNGELDPWSGGGVTKDITDTLVAVTISEGAHHLDLRTKNALDP 467
Query: 753 YDIRL 767
+ L
Sbjct: 468 TSVLL 472
>sp|P42785|PCP_HUMAN Lysosomal Pro-X carboxypeptidase precursor (Prolylcarboxypeptidase)
(PRCP) (Proline carboxypeptidase) (Angiotensinase C)
(Lysosomal carboxypeptidase C)
Length = 496
Score = 183 bits (465), Expect = 4e-46
Identities = 93/245 (37%), Positives = 139/245 (56%), Gaps = 4/245 (1%)
Frame = +3
Query: 45 KGSDACVSNVRNVWPVIQQM-NDSLHLVNLSRIFHTCQPL--KNVDDLIAVLTDGLFDMG 215
K C ++ W I ++ N L L+ H C PL +++ L +++ ++
Sbjct: 228 KSGPHCSESIHRSWDAINRLSNTGSGLQWLTGALHLCSPLTSQDIQHLKDWISETWVNLA 287
Query: 216 MANYPYPANFLGPMPAWPVKEFCKPLSNLIKDPIELLNAFFTGLQVFYNYTGQIQCLSTT 395
M +YPY +NFL P+PAWP+K C+ L N LL F L V+YNY+GQ++CL+ +
Sbjct: 288 MVDYPYASNFLQPLPAWPIKVVCQYLKNPNVSDSLLLQNIFQALNVYYNYSGQVKCLNIS 347
Query: 396 -TNLPGLDDNGWNVQTCTELPMPMCTDGVKDMFYASSFNKQNNDRSCQKSFGVTPRWGWG 572
T L GW+ Q CTE+ MP CT+GV DMF S+N + C + +GV PR W
Sbjct: 348 ETATSSLGTLGWSYQACTEVVMPFCTNGVDDMFEPHSWNLKELSDDCFQQWGVRPRPSWI 407
Query: 573 QTLFWGKNLNAASNIIFSNGLLDPWAAGGVFNSPNPSIEIVTMKNGAHHVDLRSSHPKDT 752
T++ GKN+++ +NI+FSNG LDPW+ GGV ++ VT+ GAHH+DLR+ + D
Sbjct: 408 TTMYGGKNISSHTNIVFSNGELDPWSGGGVTKDITDTLVAVTISEGAHHLDLRTKNALDP 467
Query: 753 YDIRL 767
+ L
Sbjct: 468 MSVLL 472
>sp|Q9UHL4|DPP2_HUMAN Dipeptidyl-peptidase II precursor (DPP II) (Dipeptidyl
aminopeptidase II) (Quiescent cell proline dipeptidase)
(Dipeptidyl peptidase 7)
Length = 492
Score = 149 bits (375), Expect = 1e-35
Identities = 92/250 (36%), Positives = 125/250 (50%), Gaps = 17/250 (6%)
Frame = +3
Query: 51 SDACVSNVRNVWPVIQQMNDSLHLVNLSRIFHTCQPLKNVDDLIAVLT---DGLFDMGMA 221
S C VR + I+ + + F TCQPL + DL + + + M
Sbjct: 213 SPKCTQGVREAFRQIKDLFLQGAYDTVRWEFGTCQPLSDEKDLTQLFMFARNAFTVLAMM 272
Query: 222 NYPYPANFLGPMPAWPVKEFCKPLSNLIKDPIELLNAFFTGLQVF----YNYTGQIQCLS 389
+YPYP +FLGP+PA PVK C L + + TGL+ YN +G C
Sbjct: 273 DYPYPTDFLGPLPANPVKVGCDRLLSEAQR--------ITGLRALAGLVYNASGSEHCYD 324
Query: 390 T----------TTNLPGLDDNGWNVQTCTELPMPMCTDGVKDMFYASSFNKQNNDRSCQK 539
T G D W+ Q CTE+ + ++ V DMF F + R C
Sbjct: 325 IYRLYHSCADPTGCGTGPDARAWDYQACTEINLTFASNNVTDMFPDLPFTDELRQRYCLD 384
Query: 540 SFGVTPRWGWGQTLFWGKNLNAASNIIFSNGLLDPWAAGGVFNSPNPSIEIVTMKNGAHH 719
++GV PR W T FWG +L AASNIIFSNG LDPWA GG+ + + S+ VT++ GAHH
Sbjct: 385 TWGVWPRPDWLLTSFWGGDLRAASNIIFSNGNLDPWAGGGIRRNLSASVIAVTIQGGAHH 444
Query: 720 VDLRSSHPKD 749
+DLR+SHP+D
Sbjct: 445 LDLRASHPED 454
>sp|Q9ET22|DPP2_MOUSE Dipeptidyl-peptidase II precursor (DPP II) (Dipeptidyl
aminopeptidase II) (Quiescent cell proline dipeptidase)
(Dipeptidyl peptidase 7)
Length = 506
Score = 148 bits (374), Expect = 2e-35
Identities = 90/242 (37%), Positives = 132/242 (54%), Gaps = 9/242 (3%)
Frame = +3
Query: 51 SDACVSNVRNVWPVIQQMNDSLHLVNLSRIFHTCQPL---KNVDDLIAVLTDGLFDMGMA 221
S C VR+ + I+ + +S+ F TCQ L K++ L + + M
Sbjct: 223 SPKCAQAVRDAFQQIKDLFLQGAYDTISQNFGTCQSLSSPKDLTQLFGFARNAFTVLAMM 282
Query: 222 NYPYPANFLGPMPAWPVKEFCKPLSNLIKDPIEL-----LNAFFTGLQVFYN-YTGQIQC 383
+YPYP +FLGP+PA PVK C+ L N + + L L +G + Y+ Y C
Sbjct: 283 DYPYPTDFLGPLPANPVKVGCQRLLNEGQRIMGLRALAGLVYNSSGTEPCYDIYRLYQSC 342
Query: 384 LSTTTNLPGLDDNGWNVQTCTELPMPMCTDGVKDMFYASSFNKQNNDRSCQKSFGVTPRW 563
T G D W+ Q CTE+ + ++ V DMF F+++ + C ++GV PR
Sbjct: 343 ADPTGCGTGSDARAWDYQACTEINLTFDSNNVTDMFPEIPFSEELRQQYCLDTWGVWPRQ 402
Query: 564 GWGQTLFWGKNLNAASNIIFSNGLLDPWAAGGVFNSPNPSIEIVTMKNGAHHVDLRSSHP 743
W QT FWG +L AASNIIFSNG LDPWA GG+ ++ + S+ VT++ GAHH+DLR+S+
Sbjct: 403 DWLQTSFWGGDLKAASNIIFSNGDLDPWAGGGIQSNLSTSVIAVTIQGGAHHLDLRASNS 462
Query: 744 KD 749
+D
Sbjct: 463 ED 464
>sp|Q9EPB1|DPP2_RAT Dipeptidyl-peptidase II precursor (DPP II) (Dipeptidyl
aminopeptidase II) (Quiescent cell proline dipeptidase)
(Dipeptidyl peptidase 7)
Length = 500
Score = 145 bits (366), Expect = 1e-34
Identities = 89/242 (36%), Positives = 129/242 (53%), Gaps = 9/242 (3%)
Frame = +3
Query: 51 SDACVSNVRNVWPVIQQMNDSLHLVNLSRIFHTCQPL---KNVDDLIAVLTDGLFDMGMA 221
S C VR+ + I+ + +S+ F TCQ L K++ L + + M
Sbjct: 223 SPKCAQAVRDAFQQIKDLFLQGAYDTISQNFGTCQSLSSPKDLTQLFGFARNAFTVLAMM 282
Query: 222 NYPYPANFLGPMPAWPVKEFCKPL---SNLIKDPIELLNAFF--TGLQVFYNYTGQIQ-C 383
+YPYP NFLGP+PA PVK C+ L I L + +G++ ++ Q C
Sbjct: 283 DYPYPTNFLGPLPANPVKVGCERLLSEGQRIMGLRALAGLVYNSSGMEPCFDIYQMYQSC 342
Query: 384 LSTTTNLPGLDDNGWNVQTCTELPMPMCTDGVKDMFYASSFNKQNNDRSCQKSFGVTPRW 563
T G + W+ Q CTE+ + ++ V DMF F+ + + C ++GV PR
Sbjct: 343 ADPTGCGTGSNARAWDYQACTEINLTFDSNNVTDMFPEIPFSDELRQQYCLDTWGVWPRP 402
Query: 564 GWGQTLFWGKNLNAASNIIFSNGLLDPWAAGGVFNSPNPSIEIVTMKNGAHHVDLRSSHP 743
W QT FWG +L AASNIIFSNG LDPWA GG+ + + SI VT++ GAHH+DLR+S+
Sbjct: 403 DWLQTSFWGGDLKAASNIIFSNGDLDPWAGGGIQRNLSTSIIAVTIQGGAHHLDLRASNS 462
Query: 744 KD 749
+D
Sbjct: 463 ED 464
>sp|P34676|YO26_CAEEL Putative serine protease Z688.6 precursor
Length = 507
Score = 134 bits (338), Expect = 2e-31
Identities = 83/223 (37%), Positives = 114/223 (51%), Gaps = 21/223 (9%)
Frame = +3
Query: 159 LKNVDD---LIAVLTDGLFDMGMANYPYPANFLGPMPAWPVKEFCKPLSNLIKDPIELLN 329
L+N DD L + + + M M NYPYP +FL +PAWPVKE CK S K E
Sbjct: 262 LENKDDIGFLKQYIRESMEAMAMVNYPYPTSFLSSLPAWPVKEACKSASQPGKTQEESAE 321
Query: 330 AFFTGLQVFYNYTGQ--------IQCLSTTTNLPGLDDNGWNVQTCTELPMPMCTDGVKD 485
+ + ++YNYTG +C S +L D GW QTCTE+ MP+C G +
Sbjct: 322 QLYKIVNLYYNYTGDKSTHCANAAKCDSAYGSLG--DPLGWPFQTCTEMVMPLCGSGYPN 379
Query: 486 MFYASS--FNKQNNDRSCQKSFG------VTPRWGWGQTLFWGKNLNAASNIIFSNGLLD 641
F+ F + C ++F R G F +L +ASNI+FSNG LD
Sbjct: 380 DFFWKDCPFTSEKYAEFCMQTFSSIHYNKTLLRPLAGGLAFGATSLPSASNIVFSNGYLD 439
Query: 642 PWAAGGVFNSP--NPSIEIVTMKNGAHHVDLRSSHPKDTYDIR 764
PW+ GG +S S+ V +K GAHH DLR +HP+DT +++
Sbjct: 440 PWSGGGYDHSDKVQGSVISVILKQGAHHYDLRGAHPQDTEEVK 482
>sp|P34610|PCP1_CAEEL Putative serine protease pcp-1 precursor
Length = 565
Score = 94.4 bits (233), Expect = 3e-19
Identities = 68/216 (31%), Positives = 100/216 (46%), Gaps = 24/216 (11%)
Frame = +3
Query: 174 DLIAVLTDGLFDMGMANYPYPANFLGPMPAWPVKEFCKPL--SNLIKDPIELLNAFFTGL 347
+L A L + + M M +YPYP FL P+PAWPV C + + +L+ A
Sbjct: 277 NLNAYLREAIEYMAMVDYPYPTGFLEPLPAWPVTVACGYMNANGTSFSDKDLVKAVANAA 336
Query: 348 QVFYNYTGQIQ---------CLSTTTNLPGLDDNGWNVQTCTELPMPMCTDGVKDMFYAS 500
++YNY C T G D+ GW Q C+E+ M MC G + + +
Sbjct: 337 NIYYNYNRDPNFTYCIDFSICGDQGTGGLGGDELGWPWQECSEIIMAMCASGGSNDVFWN 396
Query: 501 SFNK------QNNDRSCQKSFGVTPRWGWG----QTLFWGKNLNAASNIIFSNGLLDPWA 650
K Q S KS G TP+ W +TL+ G +L+ +SN+I + G LDPW+
Sbjct: 397 ECGKDIYQTLQQGCVSIFKSMGWTPK-NWNIDAVKTLY-GYDLSGSSNLILTQGHLDPWS 454
Query: 651 AGGV---FNSPNPSIEIVTMKNGAHHVDLRSSHPKD 749
GG N+ I ++ + AHH+DLR + D
Sbjct: 455 GGGYKVDQNNAARGIYVLEIPGSAHHLDLRQPNTCD 490
>sp|Q9NQE7|TSSP_HUMAN Thymus-specific serine protease precursor
Length = 514
Score = 50.4 bits (119), Expect = 6e-06
Identities = 36/134 (26%), Positives = 58/134 (43%), Gaps = 4/134 (2%)
Frame = +3
Query: 378 QCLSTTTNLPGLDDNGWNVQTCTELPMPMCTDGVKDMFYASSFNKQNNDRSCQKSFGVTP 557
Q ST L G+ D W QTCTE + + + F D C++ FG++
Sbjct: 357 QLRSTEPQLSGVGDRQWLYQTCTEFGFYVTCENPRCPFSQLPALPSQLDL-CEQVFGLSA 415
Query: 558 ---RWGWGQT-LFWGKNLNAASNIIFSNGLLDPWAAGGVFNSPNPSIEIVTMKNGAHHVD 725
QT ++G A+ ++F NG DPW V + S + ++ G+H +D
Sbjct: 416 LSVAQAVAQTNSYYGGQTPGANKVLFVNGDTDPWHVLSVTQALGSSESTLLIRTGSHCLD 475
Query: 726 LRSSHPKDTYDIRL 767
+ P D+ +RL
Sbjct: 476 MAPERPSDSPSLRL 489
>sp|P34528|YM67_CAEEL Putative serine protease K12H4.7 precursor
Length = 510
Score = 48.9 bits (115), Expect = 2e-05
Identities = 60/268 (22%), Positives = 98/268 (36%), Gaps = 31/268 (11%)
Frame = +3
Query: 42 TKGSDACVSNVRNVWPVIQQM-NDSLHLVNLSRIFHTCQPLKNVDDLIAVLTDGLFDMGM 218
T+ S C ++V + ++ + S L FH CQ ++ D + + ++ M
Sbjct: 232 TRNSTECAASVTQGFNLVASLLQTSDGRKQLKTAFHLCQDIQMDDKSLKYFWETVYSPYM 291
Query: 219 ANYPYPANFLGPMPAWPV--KEFCKPLSNLIKDPIELL---NAFFTGLQVFY-----NYT 368
Y + G C+ N P++ L N +F + ++ +Y
Sbjct: 292 EVVQYSGDAAGSFATQLTISHAICRYHINTKSTPLQKLKQVNDYFNQVSGYFGCNDIDYN 351
Query: 369 GQIQCLSTTTNLPGLDDNGWNVQTCTELPMPMCTD---------GVKDM----------- 488
G I + T D W QTCTE T GV ++
Sbjct: 352 GFISFMKDETFGEAQSDRAWVWQTCTEFGYYQSTSSATAGPWFGGVSNLPAQYYIDECTA 411
Query: 489 FYASSFNKQNNDRSCQKSFGVTPRWGWGQTLFWGKNLNAASNIIFSNGLLDPWAAGGVFN 668
Y +++N Q Q S T ++ G+ NLN I+ NG +DPW A G
Sbjct: 412 IYGAAYNSQE----VQTSVDYTNQYYGGRD-----NLNT-DRILLPNGDIDPWHALGKLT 461
Query: 669 SPNPSIEIVTMKNGAHHVDLRSSHPKDT 752
S N +I V + AH D+ + D+
Sbjct: 462 SSNSNIVPVVINGTAHCADMYGASSLDS 489
Database: Non-redundant SwissProt sequences
Posted date: Dec 6, 2005 7:40 AM
Number of letters in database: 68,354,980
Number of sequences in database: 184,735
Database: swissprot.01
Posted date: Dec 6, 2005 8:18 AM
Number of letters in database: 66,202,850
Number of sequences in database: 184,431
Lambda K H
0.318 0.134 0.401
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 96,135,464
Number of Sequences: 369166
Number of extensions: 2077649
Number of successful extensions: 5680
Number of sequences better than 10.0: 10
Number of HSP's better than 10.0 without gapping: 5489
Number of HSP's successfully gapped in prelim test: 0
Number of HSP's that attempted gapping in prelim test: 0
Number of HSP's gapped (non-prelim): 5664
length of database: 68,354,980
effective HSP length: 109
effective length of database: 48,218,865
effective search space used: 8004331590
frameshift window, decay const: 40, 0.1
T: 12
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)