Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= Dr_sW_004_O07
(823 letters)
Database: Non-redundant SwissProt sequences
184,735 sequences; 68,354,980 total letters
Score E
Sequences producing significant alignments: (bits) Value
sp|O61998|HSP90_BRUPA Heat shock protein 90 338 1e-92
sp|P07900|HS90A_HUMAN Heat shock protein HSP 90-alpha (HSP 86) 330 3e-90
sp|P07901|HS90A_MOUSE Heat shock protein HSP 90-alpha (HSP ... 329 5e-90
sp|O57521|HS90B_BRARE Heat shock protein HSP 90-beta 328 8e-90
sp|O02705|HS90A_PIG Heat shock protein HSP 90-alpha (HSP 86) 328 8e-90
sp|P08238|HS90B_HUMAN Heat shock protein HSP 90-beta (HSP 8... 328 1e-89
sp|P46633|HS90A_CRIGR Heat shock protein HSP 90-alpha (HSP 86) 328 1e-89
sp|Q9GKX8|HS90B_HORSE Heat shock protein HSP 90-beta (HSP 84) 327 2e-89
sp|P11501|HS90A_CHICK Heat shock protein HSP 90-alpha 327 2e-89
sp|Q90474|HS90A_BRARE Heat shock protein HSP 90-alpha 327 3e-89
>sp|O61998|HSP90_BRUPA Heat shock protein 90
Length = 717
Score = 338 bits (867), Expect = 1e-92
Identities = 179/259 (69%), Positives = 206/259 (79%), Gaps = 5/259 (1%)
Frame = +1
Query: 1 KDYVSRMKENQKDIYYITGESKDNVNHSAFVERLTKRGFEVLLMVDPIDEYSVQQLKEYD 180
KDYVSRMKENQK IY+ITGES++ V SAFVER+ +RGFEV+ M DPIDEY VQQLKEYD
Sbjct: 460 KDYVSRMKENQKQIYFITGESREAVASSAFVERVKRRGFEVIYMTDPIDEYCVQQLKEYD 519
Query: 181 GKKLVCVTXXXXXXXXXXXXXXXXXXXXXXXXXLCKVMKDILDKKVEKVTVSNRLVSSPC 360
GKKLV VT LCKVMKDIL+KKVEKV VSNRLVSSPC
Sbjct: 520 GKKLVSVTKEGLELPESEEEKKKFEEDKVKFENLCKVMKDILEKKVEKVAVSNRLVSSPC 579
Query: 361 CIVTSQYGWSANMERIMKAQALRDSSTMGYMAAKKHLEINPDHSIMKTLKARVDADKNDK 540
CIVTS+YGWSANMERIMKAQALRDSSTMGYMAAKKHLEINPDHS++K L+ RV+ADKNDK
Sbjct: 580 CIVTSEYGWSANMERIMKAQALRDSSTMGYMAAKKHLEINPDHSVIKALRERVEADKNDK 639
Query: 541 SVKDLVMLLYETSLLSSGFTLEDPQVHGNRIHRMIKLGLGI-EDDDVEMDATEAGD---- 705
+VKDLV+LL+ET+LLSSGF+LEDPQ+H +RI+RMIKLGL I ED++ E A+ +G+
Sbjct: 640 TVKDLVVLLFETALLSSGFSLEDPQLHASRIYRMIKLGLDITEDEEEEAIASVSGEKDEC 699
Query: 706 VPVVASTAEEDAGKMEEVD 762
VP + AEEDA +MEEVD
Sbjct: 700 VPNLVG-AEEDASRMEEVD 717
>sp|P07900|HS90A_HUMAN Heat shock protein HSP 90-alpha (HSP 86)
Length = 732
Score = 330 bits (846), Expect = 3e-90
Identities = 169/257 (65%), Positives = 199/257 (77%), Gaps = 3/257 (1%)
Frame = +1
Query: 1 KDYVSRMKENQKDIYYITGESKDNVNHSAFVERLTKRGFEVLLMVDPIDEYSVQQLKEYD 180
KDY +RMKENQK IYYITGE+KD V +SAFVERL K G EV+ M++PIDEY VQQLKE++
Sbjct: 478 KDYCTRMKENQKHIYYITGETKDQVANSAFVERLRKHGLEVIYMIEPIDEYCVQQLKEFE 537
Query: 181 GKKLVCVTXXXXXXXXXXXXXXXXXXXXXXXXXLCKVMKDILDKKVEKVTVSNRLVSSPC 360
GK LV VT LCK+MKDIL+KKVEKV VSNRLV+SPC
Sbjct: 538 GKTLVSVTKEGLELPEDEEEKKKQEEKKTKFENLCKIMKDILEKKVEKVVVSNRLVTSPC 597
Query: 361 CIVTSQYGWSANMERIMKAQALRDSSTMGYMAAKKHLEINPDHSIMKTLKARVDADKNDK 540
CIVTS YGW+ANMERIMKAQALRD+STMGYMAAKKHLEINPDHSI++TL+ + +ADKNDK
Sbjct: 598 CIVTSTYGWTANMERIMKAQALRDNSTMGYMAAKKHLEINPDHSIIETLRQKAEADKNDK 657
Query: 541 SVKDLVMLLYETSLLSSGFTLEDPQVHGNRIHRMIKLGLGIEDDDVEMDATEAG---DVP 711
SVKDLV+LLYET+LLSSGF+LEDPQ H NRI+RMIKLGLGI++DD D T A ++P
Sbjct: 658 SVKDLVILLYETALLSSGFSLEDPQTHANRIYRMIKLGLGIDEDDPTADDTSAAVTEEMP 717
Query: 712 VVASTAEEDAGKMEEVD 762
+ ++D +MEEVD
Sbjct: 718 PL--EGDDDTSRMEEVD 732
>sp|P07901|HS90A_MOUSE Heat shock protein HSP 90-alpha (HSP 86) (Tumor specific
transplantation 86 kDa antigen) (TSTA)
Length = 733
Score = 329 bits (844), Expect = 5e-90
Identities = 168/257 (65%), Positives = 200/257 (77%), Gaps = 3/257 (1%)
Frame = +1
Query: 1 KDYVSRMKENQKDIYYITGESKDNVNHSAFVERLTKRGFEVLLMVDPIDEYSVQQLKEYD 180
KDY +RMKENQK IY+ITGE+KD V +SAFVERL K G EV+ M++PIDEY VQQLKE++
Sbjct: 479 KDYCTRMKENQKHIYFITGETKDQVANSAFVERLRKHGLEVIYMIEPIDEYCVQQLKEFE 538
Query: 181 GKKLVCVTXXXXXXXXXXXXXXXXXXXXXXXXXLCKVMKDILDKKVEKVTVSNRLVSSPC 360
GK LV VT LCK+MKDIL+KKVEKV VSNRLV+SPC
Sbjct: 539 GKTLVSVTKEGLELPEDEEEKKKQEEKKTKFENLCKIMKDILEKKVEKVVVSNRLVTSPC 598
Query: 361 CIVTSQYGWSANMERIMKAQALRDSSTMGYMAAKKHLEINPDHSIMKTLKARVDADKNDK 540
CIVTS YGW+ANMERIMKAQALRD+STMGYMAAKKHLEINPDHSI++TL+ + +ADKNDK
Sbjct: 599 CIVTSTYGWTANMERIMKAQALRDNSTMGYMAAKKHLEINPDHSIIETLRQKAEADKNDK 658
Query: 541 SVKDLVMLLYETSLLSSGFTLEDPQVHGNRIHRMIKLGLGIEDDDVEMDATEAG---DVP 711
SVKDLV+LLYET+LLSSGF+LEDPQ H NRI+RMIKLGLGI++DD +D T A ++P
Sbjct: 659 SVKDLVILLYETALLSSGFSLEDPQTHANRIYRMIKLGLGIDEDDPTVDDTSAAVTEEMP 718
Query: 712 VVASTAEEDAGKMEEVD 762
+ ++D +MEEVD
Sbjct: 719 PL--EGDDDTSRMEEVD 733
>sp|O57521|HS90B_BRARE Heat shock protein HSP 90-beta
Length = 725
Score = 328 bits (842), Expect = 8e-90
Identities = 168/256 (65%), Positives = 196/256 (76%), Gaps = 3/256 (1%)
Frame = +1
Query: 4 DYVSRMKENQKDIYYITGESKDNVNHSAFVERLTKRGFEVLLMVDPIDEYSVQQLKEYDG 183
+YVSRMKENQK IYYITGESKD V HSAFVER+ KRGFEVL M +PIDEY VQQLK++DG
Sbjct: 470 EYVSRMKENQKSIYYITGESKDQVAHSAFVERVCKRGFEVLYMTEPIDEYCVQQLKDFDG 529
Query: 184 KKLVCVTXXXXXXXXXXXXXXXXXXXXXXXXXLCKVMKDILDKKVEKVTVSNRLVSSPCC 363
K LV VT LCK+MK+ILDKKVEKVTVSNRLVSSPCC
Sbjct: 530 KSLVSVTKEGLELPEDEDEKKKMEEDKAKFENLCKLMKEILDKKVEKVTVSNRLVSSPCC 589
Query: 364 IVTSQYGWSANMERIMKAQALRDSSTMGYMAAKKHLEINPDHSIMKTLKARVDADKNDKS 543
IVTS YGW+ANMERIMKAQALRD+STMGYM A KHLEINPDH IM+TL+ + +ADKN K+
Sbjct: 590 IVTSTYGWTANMERIMKAQALRDNSTMGYMMANKHLEINPDHPIMETLRQKAEADKNTKA 649
Query: 544 VKDLVMLLYETSLLSSGFTLEDPQVHGNRIHRMIKLGLGIEDDD---VEMDATEAGDVPV 714
VKDLV+LL+ET+LLSSGF+L+DPQ H NRI+RMIKLGLGI++D+ VE + A +
Sbjct: 650 VKDLVILLFETALLSSGFSLDDPQTHSNRIYRMIKLGLGIDEDEDVPVEEPTSAAAPEDI 709
Query: 715 VASTAEEDAGKMEEVD 762
++DA +MEEVD
Sbjct: 710 PPLEGDDDASRMEEVD 725
>sp|O02705|HS90A_PIG Heat shock protein HSP 90-alpha (HSP 86)
Length = 733
Score = 328 bits (842), Expect = 8e-90
Identities = 168/257 (65%), Positives = 199/257 (77%), Gaps = 3/257 (1%)
Frame = +1
Query: 1 KDYVSRMKENQKDIYYITGESKDNVNHSAFVERLTKRGFEVLLMVDPIDEYSVQQLKEYD 180
KDY +RMKENQK IYYITGE+KD V +SAFVERL K G EV+ M++PIDEY VQQLKE++
Sbjct: 479 KDYCTRMKENQKHIYYITGETKDQVANSAFVERLRKHGLEVIYMIEPIDEYCVQQLKEFE 538
Query: 181 GKKLVCVTXXXXXXXXXXXXXXXXXXXXXXXXXLCKVMKDILDKKVEKVTVSNRLVSSPC 360
GK LV VT LCK+MKDIL+KKVEKV VSNRLV+SPC
Sbjct: 539 GKTLVSVTKEGLELPEDEEEKKKQEEKKTKFENLCKIMKDILEKKVEKVVVSNRLVTSPC 598
Query: 361 CIVTSQYGWSANMERIMKAQALRDSSTMGYMAAKKHLEINPDHSIMKTLKARVDADKNDK 540
CIVTS YGW+ANMERIMKAQALRD+STMGYMAAKKHLEINPDHSI++TL+ + +ADKNDK
Sbjct: 599 CIVTSTYGWTANMERIMKAQALRDNSTMGYMAAKKHLEINPDHSIIETLRQKAEADKNDK 658
Query: 541 SVKDLVMLLYETSLLSSGFTLEDPQVHGNRIHRMIKLGLGIEDDDVEMDATEAG---DVP 711
SVKDLV+LLYET+LLSSGF+LEDPQ H NRI+RMIKLGLGI++DD D + A ++P
Sbjct: 659 SVKDLVILLYETALLSSGFSLEDPQTHANRIYRMIKLGLGIDEDDPTADDSSAAVTEEMP 718
Query: 712 VVASTAEEDAGKMEEVD 762
+ ++D +MEEVD
Sbjct: 719 PL--EGDDDTSRMEEVD 733
>sp|P08238|HS90B_HUMAN Heat shock protein HSP 90-beta (HSP 84) (HSP 90)
Length = 724
Score = 328 bits (840), Expect = 1e-89
Identities = 168/256 (65%), Positives = 200/256 (78%), Gaps = 3/256 (1%)
Frame = +1
Query: 4 DYVSRMKENQKDIYYITGESKDNVNHSAFVERLTKRGFEVLLMVDPIDEYSVQQLKEYDG 183
+YVSRMKE QK IYYITGESK+ V +SAFVER+ KRGFEV+ M +PIDEY VQQLKE+DG
Sbjct: 471 EYVSRMKETQKSIYYITGESKEQVANSAFVERVRKRGFEVVYMTEPIDEYCVQQLKEFDG 530
Query: 184 KKLVCVTXXXXXXXXXXXXXXXXXXXXXXXXXLCKVMKDILDKKVEKVTVSNRLVSSPCC 363
K LV VT LCK+MK+ILDKKVEKVT+SNRLVSSPCC
Sbjct: 531 KSLVSVTKEGLELPEDEEEKKKMEESKAKFENLCKLMKEILDKKVEKVTISNRLVSSPCC 590
Query: 364 IVTSQYGWSANMERIMKAQALRDSSTMGYMAAKKHLEINPDHSIMKTLKARVDADKNDKS 543
IVTS YGW+ANMERIMKAQALRD+STMGYM AKKHLEINPDH I++TL+ + +ADKNDK+
Sbjct: 591 IVTSTYGWTANMERIMKAQALRDNSTMGYMMAKKHLEINPDHPIVETLRQKAEADKNDKA 650
Query: 544 VKDLVMLLYETSLLSSGFTLEDPQVHGNRIHRMIKLGLGIEDDDV---EMDATEAGDVPV 714
VKDLV+LL+ET+LLSSGF+LEDPQ H NRI+RMIKLGLGI++D+V E +A ++P
Sbjct: 651 VKDLVVLLFETALLSSGFSLEDPQTHSNRIYRMIKLGLGIDEDEVAAEEPNAAVPDEIPP 710
Query: 715 VASTAEEDAGKMEEVD 762
+ +EDA +MEEVD
Sbjct: 711 L--EGDEDASRMEEVD 724
>sp|P46633|HS90A_CRIGR Heat shock protein HSP 90-alpha (HSP 86)
Length = 733
Score = 328 bits (840), Expect = 1e-89
Identities = 167/257 (64%), Positives = 200/257 (77%), Gaps = 3/257 (1%)
Frame = +1
Query: 1 KDYVSRMKENQKDIYYITGESKDNVNHSAFVERLTKRGFEVLLMVDPIDEYSVQQLKEYD 180
KDY +RMKENQK IY+ITGE+KD V +SAFVERL K G EV+ M++PIDEY VQQLKE++
Sbjct: 479 KDYCTRMKENQKHIYFITGETKDQVANSAFVERLRKHGLEVIYMIEPIDEYCVQQLKEFE 538
Query: 181 GKKLVCVTXXXXXXXXXXXXXXXXXXXXXXXXXLCKVMKDILDKKVEKVTVSNRLVSSPC 360
GK LV VT LCK+MKDIL+KKVEKV VSNRLV+SPC
Sbjct: 539 GKTLVSVTKEGLELPEDEEEKKKQEEKKTKFENLCKIMKDILEKKVEKVVVSNRLVTSPC 598
Query: 361 CIVTSQYGWSANMERIMKAQALRDSSTMGYMAAKKHLEINPDHSIMKTLKARVDADKNDK 540
CIVTS YGW+ANMERI+KAQALRD+STMGYMAAKKHLEINPDHSI++TL+ + +ADKNDK
Sbjct: 599 CIVTSTYGWTANMERIIKAQALRDNSTMGYMAAKKHLEINPDHSIIETLRQKAEADKNDK 658
Query: 541 SVKDLVMLLYETSLLSSGFTLEDPQVHGNRIHRMIKLGLGIEDDDVEMDATEAG---DVP 711
SVKDLV+LLYET+LLSSGF+LEDPQ H NRI+RMIKLGLGI++DD +D T A ++P
Sbjct: 659 SVKDLVILLYETALLSSGFSLEDPQTHANRIYRMIKLGLGIDEDDPTVDDTSAAVTEEMP 718
Query: 712 VVASTAEEDAGKMEEVD 762
+ ++D +MEEVD
Sbjct: 719 PL--EGDDDTSRMEEVD 733
>sp|Q9GKX8|HS90B_HORSE Heat shock protein HSP 90-beta (HSP 84)
Length = 724
Score = 327 bits (839), Expect = 2e-89
Identities = 168/256 (65%), Positives = 199/256 (77%), Gaps = 3/256 (1%)
Frame = +1
Query: 4 DYVSRMKENQKDIYYITGESKDNVNHSAFVERLTKRGFEVLLMVDPIDEYSVQQLKEYDG 183
+YVSRMKE QK IYYITGESK+ V +SAFVER+ KRGFEV+ M +PIDEY VQQLKE+DG
Sbjct: 471 EYVSRMKETQKSIYYITGESKEQVANSAFVERVRKRGFEVVYMTEPIDEYCVQQLKEFDG 530
Query: 184 KKLVCVTXXXXXXXXXXXXXXXXXXXXXXXXXLCKVMKDILDKKVEKVTVSNRLVSSPCC 363
K LV VT LCK+MK+ILDKKVEKVT+SNRLVSSPCC
Sbjct: 531 KSLVSVTKEGLELPEDEEEKKKMEESKAKFENLCKLMKEILDKKVEKVTISNRLVSSPCC 590
Query: 364 IVTSQYGWSANMERIMKAQALRDSSTMGYMAAKKHLEINPDHSIMKTLKARVDADKNDKS 543
IVTS YGW+ANMERIMKAQALRD+STMGYM AKKHLEINPDH I++TL+ + +ADKNDK+
Sbjct: 591 IVTSTYGWTANMERIMKAQALRDNSTMGYMMAKKHLEINPDHPIVETLRQKAEADKNDKA 650
Query: 544 VKDLVMLLYETSLLSSGFTLEDPQVHGNRIHRMIKLGLGIEDDDV---EMDATEAGDVPV 714
VKDLV+LL+ET+LLSSGF+LEDPQ H NRI+RMIKLGLGI++D+V E A ++P
Sbjct: 651 VKDLVVLLFETALLSSGFSLEDPQTHSNRIYRMIKLGLGIDEDEVAAEEPSAAVPDEIPP 710
Query: 715 VASTAEEDAGKMEEVD 762
+ +EDA +MEEVD
Sbjct: 711 L--EGDEDASRMEEVD 724
>sp|P11501|HS90A_CHICK Heat shock protein HSP 90-alpha
Length = 728
Score = 327 bits (839), Expect = 2e-89
Identities = 166/255 (65%), Positives = 197/255 (77%), Gaps = 1/255 (0%)
Frame = +1
Query: 1 KDYVSRMKENQKDIYYITGESKDNVNHSAFVERLTKRGFEVLLMVDPIDEYSVQQLKEYD 180
KDY +RMKENQK +YYITGE+KD V +SAFVERL K G EV+ M++PIDEY VQQLKE++
Sbjct: 474 KDYCTRMKENQKHVYYITGETKDQVANSAFVERLRKHGLEVIYMIEPIDEYCVQQLKEFE 533
Query: 181 GKKLVCVTXXXXXXXXXXXXXXXXXXXXXXXXXLCKVMKDILDKKVEKVTVSNRLVSSPC 360
GK LV VT LCK+MKDIL+KKVEKV VSNRLV+SPC
Sbjct: 534 GKTLVSVTKEGLELPEDEEEKKKQEEKKAKFENLCKIMKDILEKKVEKVVVSNRLVTSPC 593
Query: 361 CIVTSQYGWSANMERIMKAQALRDSSTMGYMAAKKHLEINPDHSIMKTLKARVDADKNDK 540
CIVTS YGW+ANMERIMKAQALRD+STMGYMAAKKHLEINPDHSI++TL+ + +ADKNDK
Sbjct: 594 CIVTSTYGWTANMERIMKAQALRDNSTMGYMAAKKHLEINPDHSIIETLRQKAEADKNDK 653
Query: 541 SVKDLVMLLYETSLLSSGFTLEDPQVHGNRIHRMIKLGLGIEDDDVEM-DATEAGDVPVV 717
SVKDLV+LLYET+LLSSGF+LEDPQ H NRI+RMIKLGLGI++DD +A+ A +
Sbjct: 654 SVKDLVILLYETALLSSGFSLEDPQTHANRIYRMIKLGLGIDEDDTAAEEASPAVTEEMP 713
Query: 718 ASTAEEDAGKMEEVD 762
++D +MEEVD
Sbjct: 714 PLEGDDDTSRMEEVD 728
>sp|Q90474|HS90A_BRARE Heat shock protein HSP 90-alpha
Length = 726
Score = 327 bits (837), Expect = 3e-89
Identities = 167/257 (64%), Positives = 197/257 (76%), Gaps = 3/257 (1%)
Frame = +1
Query: 1 KDYVSRMKENQKDIYYITGESKDNVNHSAFVERLTKRGFEVLLMVDPIDEYSVQQLKEYD 180
KDYVSRMK+ QK IYYITGE+KD V +SAFVERL K G EV+ M++PIDEY VQQLKEYD
Sbjct: 472 KDYVSRMKDTQKHIYYITGETKDQVANSAFVERLRKAGLEVIYMIEPIDEYCVQQLKEYD 531
Query: 181 GKKLVCVTXXXXXXXXXXXXXXXXXXXXXXXXXLCKVMKDILDKKVEKVTVSNRLVSSPC 360
GK LV VT LCK+MKDILDKK+EKVTVSNRLVSSPC
Sbjct: 532 GKNLVSVTKEGLELPEDEEEKKKQDELKAKYENLCKIMKDILDKKIEKVTVSNRLVSSPC 591
Query: 361 CIVTSQYGWSANMERIMKAQALRDSSTMGYMAAKKHLEINPDHSIMKTLKARVDADKNDK 540
CIVTS YGW+ANMERIMK+QALRD+STMGYM AKKHLEINP H I++TL+ + +A+KNDK
Sbjct: 592 CIVTSTYGWTANMERIMKSQALRDNSTMGYMTAKKHLEINPAHPIVETLREKAEAEKNDK 651
Query: 541 SVKDLVMLLYETSLLSSGFTLEDPQVHGNRIHRMIKLGLGIEDDD---VEMDATEAGDVP 711
+VKDLV+LL+ET+LLSSGFTL+DPQ H NRI+RMIKLGLGI+DDD E+ D+P
Sbjct: 652 AVKDLVILLFETALLSSGFTLDDPQTHANRIYRMIKLGLGIDDDDSVVEEISQPAEEDMP 711
Query: 712 VVASTAEEDAGKMEEVD 762
V+ ++D +MEEVD
Sbjct: 712 VL--EGDDDTSRMEEVD 726
Database: Non-redundant SwissProt sequences
Posted date: Dec 6, 2005 7:40 AM
Number of letters in database: 68,354,980
Number of sequences in database: 184,735
Database: swissprot.01
Posted date: Dec 6, 2005 8:18 AM
Number of letters in database: 66,202,850
Number of sequences in database: 184,431
Lambda K H
0.318 0.134 0.401
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 79,737,280
Number of Sequences: 369166
Number of extensions: 1406365
Number of successful extensions: 4466
Number of sequences better than 10.0: 10
Number of HSP's better than 10.0 without gapping: 4177
Number of HSP's successfully gapped in prelim test: 0
Number of HSP's that attempted gapping in prelim test: 0
Number of HSP's gapped (non-prelim): 4311
length of database: 68,354,980
effective HSP length: 109
effective length of database: 48,218,865
effective search space used: 7907893860
frameshift window, decay const: 40, 0.1
T: 12
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)