Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= Dr_sW_004_N15
(836 letters)
Database: Non-redundant SwissProt sequences
184,735 sequences; 68,354,980 total letters
Score E
Sequences producing significant alignments: (bits) Value
sp|Q00341|VIGLN_HUMAN Vigilin (High density lipoprotein-bin... 136 6e-32
sp|P81021|VIGLN_CHICK Vigilin 135 1e-31
sp|Q8VDJ3|VIGLN_MOUSE Vigilin (High density lipoprotein-bin... 134 2e-31
sp|Q9Z1A6|VIGLN_RAT Vigilin (High density lipoprotein-bindi... 132 9e-31
sp|P06105|SC160_YEAST Protein SCP160 (Protein HX) 73 8e-13
sp|Q80VL1|TDRKH_MOUSE Tudor and KH domain-containing protein 43 0.001
sp|Q9Y2W6|TDRKH_HUMAN Tudor and KH domain-containing protein 42 0.003
sp|P57722|PCBP3_MOUSE Poly(rC)-binding protein 3 (Alpha-CP3) 41 0.005
sp|P57721|PCBP3_HUMAN Poly(rC)-binding protein 3 (Alpha-CP3) 41 0.005
sp|Q01570|SECA_PAVLU Preprotein translocase secA subunit 39 0.018
>sp|Q00341|VIGLN_HUMAN Vigilin (High density lipoprotein-binding protein) (HDL-binding
protein)
Length = 1268
Score = 136 bits (343), Expect = 6e-32
Identities = 84/248 (33%), Positives = 134/248 (54%), Gaps = 8/248 (3%)
Frame = +2
Query: 8 DFISIKGPRANLIDAKAGLDELIVVWENEKQDRIARNFENQVPVPIVFHRKLIGQRGANI 187
D I+I G ANL AKAGL E + + E++DR R+F+ V V +H K+IG++GA I
Sbjct: 1016 DIIAITGLAANLDRAKAGLLERVKELQAEQEDRALRSFKLSVTVDPKYHPKIIGRKGAVI 1075
Query: 188 EMFRSKFNVSIQIPDQ---NSKSEEITIRGYEEDVKKAEDELLSMVDRWKAQVIEELHIP 358
R + +V+IQ PD+ N ++ITI GYE++ + A D +L +V + V E++ +
Sbjct: 1076 TQIRLEHDVNIQFPDKDDGNQPQDQITITGYEKNTEAARDAILRIVGELEQMVSEDVPLD 1135
Query: 359 RDVHPQLIGSRGSALRKLREQYNVEINFPSKNVDDDNANRVEVIGDKENVDKCCDILVEK 538
VH ++IG+RG A+RK+ +++ V+I FP D N V V G ENV++ D ++
Sbjct: 1136 HRVHARIIGARGKAIRKIMDEFKVDIRFPQSGAPDPNC--VTVTGLPENVEEAIDHILNL 1193
Query: 539 ANELLYEWEERNQVREVKNSIKDRENVNSNNLKEKGPGFLLAGAPW-----QRVPDASSN 703
E L + + ++ E K GF++ APW ++ PD SS+
Sbjct: 1194 EEEYLADVVDSEALQVYMKPPAHEE------AKAPSRGFVVRDAPWTASSSEKAPDMSSS 1247
Query: 704 VDFPTIDA 727
+FP+ A
Sbjct: 1248 EEFPSFGA 1255
Score = 86.7 bits (213), Expect = 7e-17
Identities = 54/183 (29%), Positives = 100/183 (54%), Gaps = 1/183 (0%)
Frame = +2
Query: 8 DFISIKGPRANLIDAKAGLDELIVVWENEKQDRIARNFENQVPVPIVFHRKLIGQRGANI 187
D I+++GP ++ A+ ++ ++ +D I R ++ + FHR LIG+ GANI
Sbjct: 406 DKITLEGPTEDVNVAQEQIEGMV-------KDLINRMDYVEINIDHKFHRHLIGKSGANI 458
Query: 188 EMFRSKFNVSIQIPDQNSKSEEITIRGYEEDVKKAEDELLSMVDRWKAQVIEELHIPRDV 367
+ ++ VS++IP + KS I I G + V++A+ ELL + R + + ++L I +
Sbjct: 459 NRIKDQYKVSVRIPPDSEKSNLIRIEGDPQGVQQAKRELLELASRMENERTKDLIIEQRF 518
Query: 368 HPQLIGSRGSALRKLREQY-NVEINFPSKNVDDDNANRVEVIGDKENVDKCCDILVEKAN 544
H +IG +G +R++R+++ V INFP D V++ G K V+KC + +
Sbjct: 519 HRTIIGQKGERIREIRDKFPEVIINFPDPAQKSD---IVQLRGPKNEVEKCTKYMQKMVA 575
Query: 545 ELL 553
+L+
Sbjct: 576 DLV 578
Score = 80.9 bits (198), Expect = 4e-15
Identities = 52/182 (28%), Positives = 93/182 (51%), Gaps = 2/182 (1%)
Frame = +2
Query: 8 DFISIKGPRANLIDAKAGLDELIVVWENEKQDRIARNFENQVPVPIVFHRKLIGQRGANI 187
D + ++GP+ + + +++ D + ++ VP+ FH+ +IG+ GANI
Sbjct: 552 DIVQLRGPKNEVEKCTKYMQKMVA-------DLVENSYSISVPIFKQFHKNIIGKGGANI 604
Query: 188 EMFRSKFNVSIQIPDQNSKSEEITIRGYEEDVKKAEDELLSMVDRWKAQVIE-ELHIPRD 364
+ R + N I +P +NS SE I I G + + A +LS + + A + E E+ IP
Sbjct: 605 KKIREESNTKIDLPAENSNSETIIITGKRANCEAARSRILS-IQKDLANIAEVEVSIPAK 663
Query: 365 VHPQLIGSRGSALRKLREQY-NVEINFPSKNVDDDNANRVEVIGDKENVDKCCDILVEKA 541
+H LIG++G +R + E+ V I+FP V+ ++ V + G +V+K L+ A
Sbjct: 664 LHNSLIGTKGRLIRSIMEECGGVHIHFP---VEGSGSDTVVIRGPSSDVEKAKKQLLHLA 720
Query: 542 NE 547
E
Sbjct: 721 EE 722
Score = 74.7 bits (182), Expect = 3e-13
Identities = 48/189 (25%), Positives = 90/189 (47%), Gaps = 8/189 (4%)
Frame = +2
Query: 8 DFISIKGPRANLIDAKAGLDELIVVWENEKQDRIARNFENQVPVPIVFHRKLIGQRGANI 187
D I I G + AK L+ L+ V +V VP HR +IGQ+G+ I
Sbjct: 949 DIIIISGRKEKCEAAKEALEALVPV-------------TIEVEVPFDLHRYVIGQKGSGI 995
Query: 188 EMFRSKFNVSIQIPDQNSKSEEITIRGYEEDVKKAEDELLSMVDRWKAQVIE-------- 343
+F V+I +P +S+ I I G ++ +A+ LL V +A+ +
Sbjct: 996 RKMMDEFEVNIHVPAPELQSDIIAITGLAANLDRAKAGLLERVKELQAEQEDRALRSFKL 1055
Query: 344 ELHIPRDVHPQLIGSRGSALRKLREQYNVEINFPSKNVDDDNANRVEVIGDKENVDKCCD 523
+ + HP++IG +G+ + ++R +++V I FP K+ + +++ + G ++N + D
Sbjct: 1056 SVTVDPKYHPKIIGRKGAVITQIRLEHDVNIQFPDKDDGNQPQDQITITGYEKNTEAARD 1115
Query: 524 ILVEKANEL 550
++ EL
Sbjct: 1116 AILRIVGEL 1124
Score = 67.8 bits (164), Expect = 4e-11
Identities = 54/230 (23%), Positives = 103/230 (44%), Gaps = 32/230 (13%)
Frame = +2
Query: 8 DFISIKGPRANLIDAKAGLDELIVVWENEKQDRIARNFENQVPVPIVFHRKLIGQRGANI 187
D +++KG + + AK + E+I + + + +P FHR ++G +G+ I
Sbjct: 845 DKVTLKGAKDCVEAAKKRIQEII--------EDLEAQVTLECAIPQKFHRSVMGPKGSRI 896
Query: 188 EMFRSKFNVSIQIPDQNS--------------------------------KSEEITIRGY 271
+ F+V I+ PD+ + + I I G
Sbjct: 897 QQITRDFSVQIKFPDREENAVHSTEPVVQENGDEAGEGREAKDCDPGSPRRCDIIIISGR 956
Query: 272 EEDVKKAEDELLSMVDRWKAQVIEELHIPRDVHPQLIGSRGSALRKLREQYNVEINFPSK 451
+E + A++ L ++V V E+ +P D+H +IG +GS +RK+ +++ V I+ P+
Sbjct: 957 KEKCEAAKEALEALV-----PVTIEVEVPFDLHRYVIGQKGSGIRKMMDEFEVNIHVPAP 1011
Query: 452 NVDDDNANRVEVIGDKENVDKCCDILVEKANELLYEWEERNQVREVKNSI 601
+ D + + G N+D+ L+E+ EL E E+R +R K S+
Sbjct: 1012 ELQSD---IIAITGLAANLDRAKAGLLERVKELQAEQEDR-ALRSFKLSV 1057
Score = 63.9 bits (154), Expect = 5e-10
Identities = 46/167 (27%), Positives = 80/167 (47%), Gaps = 2/167 (1%)
Frame = +2
Query: 14 ISIKGPRANLIDAKAGLDELIVVWENEKQDRIARNFENQVPVPIVFHRKLIGQRGANIEM 193
I I G RAN A++ + + Q +A E +V +P H LIG +G I
Sbjct: 627 IIITGKRANCEAARSRILSI--------QKDLANIAEVEVSIPAKLHNSLIGTKGRLIRS 678
Query: 194 FRSKFN-VSIQIPDQNSKSEEITIRGYEEDVKKAEDELLSMVDRWKAQVIE-ELHIPRDV 367
+ V I P + S S+ + IRG DV+KA+ +LL + + + + ++ +
Sbjct: 679 IMEECGGVHIHFPVEGSGSDTVVIRGPSSDVEKAKKQLLHLAEEKQTKSFTVDIRAKPEY 738
Query: 368 HPQLIGSRGSALRKLREQYNVEINFPSKNVDDDNANRVEVIGDKENV 508
H LIG G +RK+R+ + FP+ +D + + + +IG ++ V
Sbjct: 739 HKFLIGKGGGKIRKVRDSTGARVIFPA--AEDKDQDLITIIGKEDAV 783
Score = 61.6 bits (148), Expect = 3e-09
Identities = 36/128 (28%), Positives = 63/128 (49%), Gaps = 2/128 (1%)
Frame = +2
Query: 131 VPVPIVFHRKLIGQRGANIEMFRSKFNVSIQIPDQNSKSEEITIRGYEEDVKKAEDELLS 310
V +P HR +IG+ G ++ K IQIP + S +I I G +E ++KA E+L
Sbjct: 155 VAIPKEHHRFVIGKNGEKLQDLELKTATKIQIPRPDDPSNQIKITGTKEGIEKARHEVLL 214
Query: 311 MVDRWKAQVIEELHIPRDVHPQLIGSRGSALRKLREQYNVEINFPSKNVDDDNANRVEVI 490
+ + +E L + + HP + G + ++ ++ IN P +V NR E++
Sbjct: 215 ISAEQDKRAVERLEVEKAFHPFIAGPYNRLVGEIMQETGTRINIPPPSV-----NRTEIV 269
Query: 491 --GDKENV 508
G+KE +
Sbjct: 270 FTGEKEQL 277
Score = 60.8 bits (146), Expect = 4e-09
Identities = 36/149 (24%), Positives = 78/149 (52%), Gaps = 1/149 (0%)
Frame = +2
Query: 8 DFISIKGPRANLIDAKAGLDELIVVWENEKQDRIARNFENQVPVPIVFHRKLIGQRGANI 187
D I+I G + +A+ L+ LI +N +D + V HR + +RG +
Sbjct: 772 DLITIIGKEDAVREAQKELEALIQNLDNVVEDSML--------VDPKHHRHFVIRRGQVL 823
Query: 188 EMFRSKFN-VSIQIPDQNSKSEEITIRGYEEDVKKAEDELLSMVDRWKAQVIEELHIPRD 364
++ V + P ++S+++T++G ++ V+ A+ + +++ +AQV E IP+
Sbjct: 824 REIAEEYGGVMVSFPRSGTQSDKVTLKGAKDCVEAAKKRIQEIIEDLEAQVTLECAIPQK 883
Query: 365 VHPQLIGSRGSALRKLREQYNVEINFPSK 451
H ++G +GS ++++ ++V+I FP +
Sbjct: 884 FHRSVMGPKGSRIQQITRDFSVQIKFPDR 912
Score = 59.3 bits (142), Expect = 1e-08
Identities = 48/188 (25%), Positives = 87/188 (46%), Gaps = 2/188 (1%)
Frame = +2
Query: 8 DFISIKGPRANLIDAKAGLDELIVVWENEKQDRIARNFENQVPVPIVFHRKLIGQRGANI 187
D + I+GP +++ AK L L EKQ ++F + +H+ LIG+ G I
Sbjct: 698 DTVVIRGPSSDVEKAKKQLLHLA----EEKQ---TKSFTVDIRAKPEYHKFLIGKGGGKI 750
Query: 188 EMFRSKFNVSIQIPDQNSKSEE-ITIRGYEEDVKKAEDELLSMVDRWKAQVIEELHIPRD 364
R + P K ++ ITI G E+ V++A+ EL +++ V + + +
Sbjct: 751 RKVRDSTGARVIFPAAEDKDQDLITIIGKEDAVREAQKELEALIQNLDNVVEDSMLVDPK 810
Query: 365 VHPQLIGSRGSALRKLREQY-NVEINFPSKNVDDDNANRVEVIGDKENVDKCCDILVEKA 541
H + RG LR++ E+Y V ++FP D +V + G K+ C + ++
Sbjct: 811 HHRHFVIRRGQVLREIAEEYGGVMVSFPRSGTQSD---KVTLKGAKD----CVEAAKKRI 863
Query: 542 NELLYEWE 565
E++ + E
Sbjct: 864 QEIIEDLE 871
Score = 50.4 bits (119), Expect = 6e-06
Identities = 47/221 (21%), Positives = 98/221 (44%), Gaps = 15/221 (6%)
Frame = +2
Query: 26 GPRANLIDAKAGLDELIVVWENEKQD----RIARNFENQ--------VPVPIVFHRKLIG 169
G R N+ E++ E E+ RI + +E + V V H+ +IG
Sbjct: 253 GTRINIPPPSVNRTEIVFTGEKEQLAQAVARIKKIYEEKKKKTTTIAVEVKKSQHKYVIG 312
Query: 170 QRGANIEMFRSKFNVSIQIPDQNSKSEEITIRGYEEDVKKAEDELLSMVDRWKAQVIEEL 349
+G +++ + VS++IP +S SE + +RG E + +A E+ + + + + +
Sbjct: 313 PKGNSLQEILERTGVSVEIPPSDSISETVILRGEPEKLGQALTEVYAKANSF---TVSSV 369
Query: 350 HIPRDVHPQLIGSRGSALRKLREQY-NVEINFPSKNVDDDNANRVEVIGDKENVDKCCDI 526
P +H +IG +G L K+ +Q V I F + +++ + G E+V+ +
Sbjct: 370 AAPSWLHRFIIGKKGQNLAKITQQMPKVHIEF------TEGEDKITLEGPTEDVNVAQEQ 423
Query: 527 LVEKANELL--YEWEERNQVREVKNSIKDRENVNSNNLKEK 643
+ +L+ ++ E N + + + N N +K++
Sbjct: 424 IEGMVKDLINRMDYVEINIDHKFHRHLIGKSGANINRIKDQ 464
>sp|P81021|VIGLN_CHICK Vigilin
Length = 1270
Score = 135 bits (340), Expect = 1e-31
Identities = 83/248 (33%), Positives = 136/248 (54%), Gaps = 8/248 (3%)
Frame = +2
Query: 8 DFISIKGPRANLIDAKAGLDELIVVWENEKQDRIARNFENQVPVPIVFHRKLIGQRGANI 187
D I+I G ANL AKAGL E + + E++DR R+F+ V V +H K+IG++GA I
Sbjct: 1018 DIITITGLAANLDRAKAGLLERVKELQAEQEDRALRSFKLTVTVDPKYHPKIIGRKGAVI 1077
Query: 188 EMFRSKFNVSIQIPDQNSKSE---EITIRGYEEDVKKAEDELLSMVDRWKAQVIEELHIP 358
R++ V+IQ PD++ +S+ +ITI GYE++ + A D ++ +V + V E++ +
Sbjct: 1078 TQIRTEHEVNIQFPDKDDESQAQDQITITGYEKNAEAARDAIMKIVGELEQMVSEDVTLD 1137
Query: 359 RDVHPQLIGSRGSALRKLREQYNVEINFPSKNVDDDNANRVEVIGDKENVDKCCDILVEK 538
VH ++IG+RG A+RK+ +++ V+I FP D N V V G ENV++ D ++
Sbjct: 1138 HRVHARIIGARGKAIRKIMDEFKVDIRFPQSGAPDPNC--VTVTGLPENVEEAIDHILNL 1195
Query: 539 ANELLYEWEERNQVREVKNSIKDRENVNSNNLKEKGPGFLLAGAPW-----QRVPDASSN 703
E L + + ++ E+ K GF++ AP ++ PD SS+
Sbjct: 1196 EEEYLADVVDNEAMQVYMKPSSHEES------KVPSKGFVVRDAPCGTVNNEKAPDMSSS 1249
Query: 704 VDFPTIDA 727
DFP+ A
Sbjct: 1250 EDFPSFGA 1257
Score = 89.4 bits (220), Expect = 1e-17
Identities = 57/183 (31%), Positives = 98/183 (53%), Gaps = 1/183 (0%)
Frame = +2
Query: 8 DFISIKGPRANLIDAKAGLDELIVVWENEKQDRIARNFENQVPVPIVFHRKLIGQRGANI 187
D I+ +GP ++ A+ ++ ++ +D I R ++ V FHR LIG+ GANI
Sbjct: 405 DKITSEGPTEDVNVAQEQIEVMV-------KDLINRTDYAEINVDHKFHRHLIGKNGANI 457
Query: 188 EMFRSKFNVSIQIPDQNSKSEEITIRGYEEDVKKAEDELLSMVDRWKAQVIEELHIPRDV 367
+ + VS++IP N KS I I G + V++A+ ELL + R + + ++L I +
Sbjct: 458 NRIKDLYKVSVRIPPDNEKSNLIRIEGDPQGVQQAKKELLELASRMENERTKDLIIEQKF 517
Query: 368 HPQLIGSRGSALRKLREQY-NVEINFPSKNVDDDNANRVEVIGDKENVDKCCDILVEKAN 544
H +IG +G +R++RE++ V INFP D V++ G K V+KC + +
Sbjct: 518 HRTIIGQKGERIREIREKFPEVIINFPDPAHKSD---IVQLRGPKNEVEKCTKYMQKMVA 574
Query: 545 ELL 553
+L+
Sbjct: 575 DLV 577
Score = 77.4 bits (189), Expect = 5e-14
Identities = 51/190 (26%), Positives = 91/190 (47%), Gaps = 9/190 (4%)
Frame = +2
Query: 8 DFISIKGPRANLIDAKAGLDELIVVWENEKQDRIARNFENQVPVPIVFHRKLIGQRGANI 187
D I I G R AK L L+ V +V VP HR +IGQ+G+ I
Sbjct: 950 DIIIISGRREKCEAAKEALQALVPV-------------TIEVEVPFDLHRYIIGQKGSGI 996
Query: 188 EMFRSKFNVSIQIPDQNSKSEE-ITIRGYEEDVKKAEDELLSMVDRWKAQVIEE------ 346
+F V+IQ+P +S + ITI G ++ +A+ LL V +A+ +
Sbjct: 997 RKMMDEFEVNIQVPAPELQSSDIITITGLAANLDRAKAGLLERVKELQAEQEDRALRSFK 1056
Query: 347 --LHIPRDVHPQLIGSRGSALRKLREQYNVEINFPSKNVDDDNANRVEVIGDKENVDKCC 520
+ + HP++IG +G+ + ++R ++ V I FP K+ + +++ + G ++N +
Sbjct: 1057 LTVTVDPKYHPKIIGRKGAVITQIRTEHEVNIQFPDKDDESQAQDQITITGYEKNAEAAR 1116
Query: 521 DILVEKANEL 550
D +++ EL
Sbjct: 1117 DAIMKIVGEL 1126
Score = 66.6 bits (161), Expect = 8e-11
Identities = 53/220 (24%), Positives = 99/220 (45%), Gaps = 32/220 (14%)
Frame = +2
Query: 8 DFISIKGPRANLIDAKAGLDELIVVWENEKQDRIARNFENQVPVPIVFHRKLIGQRGANI 187
D +++KG + + AK + E+I + E Q I + +P FHR ++G +G+ I
Sbjct: 846 DKVTLKGAKDCVEAAKKRIQEIIE--DLEAQVTI------ECTIPQKFHRSIMGPKGSRI 897
Query: 188 EMFRSKFNVSIQIPDQNS--------------------------------KSEEITIRGY 271
+ + V I+ PD+ K + I I G
Sbjct: 898 QQITRDYGVQIKFPDREENPAPVAEPALQENGEEGGEGKDGKDADPSSPRKCDIIIISGR 957
Query: 272 EEDVKKAEDELLSMVDRWKAQVIEELHIPRDVHPQLIGSRGSALRKLREQYNVEINFPSK 451
E + A++ L ++V V E+ +P D+H +IG +GS +RK+ +++ V I P+
Sbjct: 958 REKCEAAKEALQALV-----PVTIEVEVPFDLHRYIIGQKGSGIRKMMDEFEVNIQVPAP 1012
Query: 452 NVDDDNANRVEVIGDKENVDKCCDILVEKANELLYEWEER 571
+ +++ + + G N+D+ L+E+ EL E E+R
Sbjct: 1013 EL--QSSDIITITGLAANLDRAKAGLLERVKELQAEQEDR 1050
Score = 66.2 bits (160), Expect = 1e-10
Identities = 40/151 (26%), Positives = 80/151 (52%), Gaps = 3/151 (1%)
Frame = +2
Query: 8 DFISIKGPRANLIDAKAGLDELIVVWENEKQDRIARNFENQVPVPIVFHRKLIGQRGANI 187
D + ++GP+ + + +++ D + +F VP+ FH+ +IG+ GANI
Sbjct: 551 DIVQLRGPKNEVEKCTKYMQKMVA-------DLVENSFSISVPIFKQFHKNIIGKGGANI 603
Query: 188 EMFRSKFNVSIQIPDQNSKSE-EITIRGYEEDVKKAEDELLSMVDRWKAQVIE-ELHIPR 361
+ R + N I +P + ++ ++ +G E+ VK +L+ + + A + E E+ IP
Sbjct: 604 KKIREESNTKIDLPGREQATQRQLLSQGREQTVKLLRHRILA-IQKELANITEVEVSIPS 662
Query: 362 DVHPQLIGSRGSALRKLREQY-NVEINFPSK 451
+H LIG++G +R + E+ V I+FP++
Sbjct: 663 KLHNSLIGAKGRFIRSIMEECGGVHIHFPTE 693
Score = 64.7 bits (156), Expect = 3e-10
Identities = 46/177 (25%), Positives = 75/177 (42%), Gaps = 8/177 (4%)
Frame = +2
Query: 2 CLDFISIKGPRANLIDAK--------AGLDELIVVWENEKQDRIARNFENQVPVPIVFHR 157
CLD + G L AK +G E ++ E R+ V +P HR
Sbjct: 103 CLDIMQKTGAHLELSLAKDQGLSIMVSGKLEAVMKARKEIVARLQTQASATVAIPKEHHR 162
Query: 158 KLIGQRGANIEMFRSKFNVSIQIPDQNSKSEEITIRGYEEDVKKAEDELLSMVDRWKAQV 337
+IG+ G ++ K IQIP + S +I I G +E ++KA E+L + +
Sbjct: 163 FVIGKNGEKLQDLELKTATKIQIPRPDDPSNQIKITGTKEGIEKARHEILLISAEQDKRA 222
Query: 338 IEELHIPRDVHPQLIGSRGSALRKLREQYNVEINFPSKNVDDDNANRVEVIGDKENV 508
+E L + + HP + G + +L + IN P +V N + G+KE +
Sbjct: 223 VERLDVEKVYHPFIAGPYNKLVSELMQDTGTRINIPPPSV---NKTEIVFTGEKEQL 276
Score = 59.3 bits (142), Expect = 1e-08
Identities = 36/150 (24%), Positives = 79/150 (52%), Gaps = 2/150 (1%)
Frame = +2
Query: 8 DFISIKGPRANLIDAKAGLDELIVVWENEKQDRIARNFENQVPVPIVFHRKLIGQRGANI 187
+ I+I G + +A+ L+ LI +N +D + V HR + +RG +
Sbjct: 772 ELITIMGTEEAVKEAQKELEALIKNLDNVVEDSMV--------VDPKHHRHFVIRRGQVL 823
Query: 188 EMFRSKFN-VSIQIPD-QNSKSEEITIRGYEEDVKKAEDELLSMVDRWKAQVIEELHIPR 361
++ V +++P ++S+++T++G ++ V+ A+ + +++ +AQV E IP+
Sbjct: 824 REIADEYGGVMVRLPTVSGTQSDKVTLKGAKDCVEAAKKRIQEIIEDLEAQVTIECTIPQ 883
Query: 362 DVHPQLIGSRGSALRKLREQYNVEINFPSK 451
H ++G +GS ++++ Y V+I FP +
Sbjct: 884 KFHRSIMGPKGSRIQQITRDYGVQIKFPDR 913
Score = 58.9 bits (141), Expect = 2e-08
Identities = 43/163 (26%), Positives = 77/163 (47%), Gaps = 2/163 (1%)
Frame = +2
Query: 83 WENEKQDRIARNFENQVPVPIVFHRKLIGQRGANIEMFRSKFNVSIQIPDQNSKSEE-IT 259
W EKQ +++ + +H+ LIG+ G NI R I P K +E IT
Sbjct: 719 WAEEKQ---TKSYTVDLRAKPEYHKFLIGKGGGNIRKVRDNTGARIIFPTSEDKDQELIT 775
Query: 260 IRGYEEDVKKAEDELLSMVDRWKAQVIEELHIPRDVHPQLIGSRGSALRKLREQY-NVEI 436
I G EE VK+A+ EL +++ V + + + H + RG LR++ ++Y V +
Sbjct: 776 IMGTEEAVKEAQKELEALIKNLDNVVEDSMVVDPKHHRHFVIRRGQVLREIADEYGGVMV 835
Query: 437 NFPSKNVDDDNANRVEVIGDKENVDKCCDILVEKANELLYEWE 565
P+ V +++V + G K+ C + ++ E++ + E
Sbjct: 836 RLPT--VSGTQSDKVTLKGAKD----CVEAAKKRIQEIIEDLE 872
Score = 48.9 bits (115), Expect = 2e-05
Identities = 46/220 (20%), Positives = 96/220 (43%), Gaps = 15/220 (6%)
Frame = +2
Query: 26 GPRANLIDAKAGLDELIVVWENEKQD----RIARNFENQ--------VPVPIVFHRKLIG 169
G R N+ E++ E E+ R+ + +E + V V H+ +IG
Sbjct: 252 GTRINIPPPSVNKTEIVFTGEKEQLAQAVARVKKIYEEKKKKTTTIAVEVKKSQHKYVIG 311
Query: 170 QRGANIEMFRSKFNVSIQIPDQNSKSEEITIRGYEEDVKKAEDELLSMVDRWKAQVIEEL 349
++G +++ K VS++IP +S SE + +RG E + +A E+ + + + + +
Sbjct: 312 RKGNSLQEILEKTGVSVEIPPTDSSSETVILRGEPEKLGQALTEVYAKANSF---TVSSV 368
Query: 350 HIPRDVHPQLIGSRGSALRKLREQY-NVEINFPSKNVDDDNANRVEVIGDKENVDKCCDI 526
P +H +IG G L K+ +Q + I F + +++ G E+V+ +
Sbjct: 369 SAPSWLHRFIIGLFGQNLAKITQQMPKIHIEF------TEGEDKITSEGPTEDVNVAQEQ 422
Query: 527 LVEKANELL--YEWEERNQVREVKNSIKDRENVNSNNLKE 640
+ +L+ ++ E N + + + N N +K+
Sbjct: 423 IEVMVKDLINRTDYAEINVDHKFHRHLIGKNGANINRIKD 462
>sp|Q8VDJ3|VIGLN_MOUSE Vigilin (High density lipoprotein-binding protein) (HDL-binding
protein)
Length = 1268
Score = 134 bits (338), Expect = 2e-31
Identities = 82/248 (33%), Positives = 134/248 (54%), Gaps = 8/248 (3%)
Frame = +2
Query: 8 DFISIKGPRANLIDAKAGLDELIVVWENEKQDRIARNFENQVPVPIVFHRKLIGQRGANI 187
D I+I G ANL AKAGL + + + E++DR R+F+ V V +H K+IG++GA I
Sbjct: 1016 DTIAITGLAANLDRAKAGLLDRVKELQAEQEDRALRSFKLSVTVDPKYHPKIIGRKGAVI 1075
Query: 188 EMFRSKFNVSIQIPDQ---NSKSEEITIRGYEEDVKKAEDELLSMVDRWKAQVIEELHIP 358
R + V+IQ PD+ N ++ITI GYE++ + A D +L +V + V E++ +
Sbjct: 1076 TQIRLEHEVNIQFPDKDDGNQPQDQITITGYEKNTEAARDAILKIVGELEQMVSEDVPLD 1135
Query: 359 RDVHPQLIGSRGSALRKLREQYNVEINFPSKNVDDDNANRVEVIGDKENVDKCCDILVEK 538
VH ++IG+RG A+RK+ +++ V+I FP D N V V G ENV++ D ++
Sbjct: 1136 HRVHARIIGARGKAIRKIMDEFKVDIRFPQSGAPDPNC--VTVTGLPENVEEAIDHILNL 1193
Query: 539 ANELLYEWEERNQVREVKNSIKDRENVNSNNLKEKGPGFLLAGAPW-----QRVPDASSN 703
E L + + ++ E+ + GF++ APW ++ PD SS+
Sbjct: 1194 EEEYLADVVDSEALQVYMKPPAHEES------RAPSKGFVVRDAPWTSNSSEKAPDMSSS 1247
Query: 704 VDFPTIDA 727
+FP+ A
Sbjct: 1248 EEFPSFGA 1255
Score = 86.7 bits (213), Expect = 7e-17
Identities = 54/183 (29%), Positives = 100/183 (54%), Gaps = 1/183 (0%)
Frame = +2
Query: 8 DFISIKGPRANLIDAKAGLDELIVVWENEKQDRIARNFENQVPVPIVFHRKLIGQRGANI 187
D I+++GP ++ A+ ++ ++ +D I R ++ + FHR LIG+ GANI
Sbjct: 406 DKITLEGPTEDVNVAQEQIEGMV-------KDLINRMDYVEINIDHKFHRHLIGKSGANI 458
Query: 188 EMFRSKFNVSIQIPDQNSKSEEITIRGYEEDVKKAEDELLSMVDRWKAQVIEELHIPRDV 367
+ ++ VS++IP + KS I I G + V++A+ ELL + R + + ++L I +
Sbjct: 459 NRIKDQYKVSVRIPPDSEKSNLIRIEGDPQGVQQAKRELLELASRMENERTKDLIIEQRF 518
Query: 368 HPQLIGSRGSALRKLREQY-NVEINFPSKNVDDDNANRVEVIGDKENVDKCCDILVEKAN 544
H +IG +G +R++R+++ V INFP D V++ G K V+KC + +
Sbjct: 519 HRTIIGQKGERIREIRDKFPEVIINFPDPAQKSD---IVQLRGPKNEVEKCTKYMQKMVA 575
Query: 545 ELL 553
+L+
Sbjct: 576 DLV 578
Score = 80.9 bits (198), Expect = 4e-15
Identities = 52/182 (28%), Positives = 93/182 (51%), Gaps = 2/182 (1%)
Frame = +2
Query: 8 DFISIKGPRANLIDAKAGLDELIVVWENEKQDRIARNFENQVPVPIVFHRKLIGQRGANI 187
D + ++GP+ + + +++ D + ++ VP+ FH+ +IG+ GANI
Sbjct: 552 DIVQLRGPKNEVEKCTKYMQKMVA-------DLVENSYSISVPIFKQFHKNIIGKGGANI 604
Query: 188 EMFRSKFNVSIQIPDQNSKSEEITIRGYEEDVKKAEDELLSMVDRWKAQVIE-ELHIPRD 364
+ R + N I +P +NS SE I I G + + A +LS + + A + E E+ IP
Sbjct: 605 KKIREESNTKIDLPAENSNSETIIITGKRANCEAARSRILS-IQKDLANIAEVEVSIPAK 663
Query: 365 VHPQLIGSRGSALRKLREQY-NVEINFPSKNVDDDNANRVEVIGDKENVDKCCDILVEKA 541
+H LIG++G +R + E+ V I+FP V+ ++ V + G +V+K L+ A
Sbjct: 664 LHNSLIGTKGRLIRSIMEECGGVHIHFP---VEGSGSDTVVIRGPSSDVEKAKKQLLHLA 720
Query: 542 NE 547
E
Sbjct: 721 EE 722
Score = 75.9 bits (185), Expect = 1e-13
Identities = 48/189 (25%), Positives = 90/189 (47%), Gaps = 8/189 (4%)
Frame = +2
Query: 8 DFISIKGPRANLIDAKAGLDELIVVWENEKQDRIARNFENQVPVPIVFHRKLIGQRGANI 187
D I I G + AK L+ L+ V +V VP HR +IGQ+G+ I
Sbjct: 949 DIIIISGRKEKCEAAKEALEALVPV-------------TIEVEVPFDLHRYIIGQKGSGI 995
Query: 188 EMFRSKFNVSIQIPDQNSKSEEITIRGYEEDVKKAEDELLSMVDRWKAQVIE-------- 343
+F V+I +P +S+ I I G ++ +A+ LL V +A+ +
Sbjct: 996 RKMMDEFEVNIHVPAPELQSDTIAITGLAANLDRAKAGLLDRVKELQAEQEDRALRSFKL 1055
Query: 344 ELHIPRDVHPQLIGSRGSALRKLREQYNVEINFPSKNVDDDNANRVEVIGDKENVDKCCD 523
+ + HP++IG +G+ + ++R ++ V I FP K+ + +++ + G ++N + D
Sbjct: 1056 SVTVDPKYHPKIIGRKGAVITQIRLEHEVNIQFPDKDDGNQPQDQITITGYEKNTEAARD 1115
Query: 524 ILVEKANEL 550
+++ EL
Sbjct: 1116 AILKIVGEL 1124
Score = 65.5 bits (158), Expect = 2e-10
Identities = 39/149 (26%), Positives = 78/149 (52%), Gaps = 1/149 (0%)
Frame = +2
Query: 8 DFISIKGPRANLIDAKAGLDELIVVWENEKQDRIARNFENQVPVPIVFHRKLIGQRGANI 187
D I+I G + +A+ L+ LI EN +D + V HR + +RG +
Sbjct: 772 DLITIIGKEDAVREAQKELEALIQNLENVVEDYML--------VDPKHHRHFVIRRGQVL 823
Query: 188 EMFRSKFN-VSIQIPDQNSKSEEITIRGYEEDVKKAEDELLSMVDRWKAQVIEELHIPRD 364
++ V + P ++S+++T++G ++ V+ A+ + +++ +AQV E IP+
Sbjct: 824 REIAEEYGGVMVSFPRSGTQSDKVTLKGAKDCVEAAKKRIQEIIEDLEAQVTVECAIPQK 883
Query: 365 VHPQLIGSRGSALRKLREQYNVEINFPSK 451
H ++G +GS ++++ YNV+I FP +
Sbjct: 884 FHRSVMGPKGSRIQQITRDYNVQIKFPDR 912
Score = 64.7 bits (156), Expect = 3e-10
Identities = 37/128 (28%), Positives = 64/128 (50%), Gaps = 2/128 (1%)
Frame = +2
Query: 131 VPVPIVFHRKLIGQRGANIEMFRSKFNVSIQIPDQNSKSEEITIRGYEEDVKKAEDELLS 310
VP+P HR +IG+ G ++ K IQIP + S +I I G +E ++KA E+L
Sbjct: 155 VPIPKEHHRFVIGKNGEKLQDLELKTATKIQIPRPDDPSNQIKITGTKEGIEKARHEVLL 214
Query: 311 MVDRWKAQVIEELHIPRDVHPQLIGSRGSALRKLREQYNVEINFPSKNVDDDNANRVEVI 490
+ + +E L + + HP + G + ++ ++ IN P +V NR E++
Sbjct: 215 ISAEQDKRAVERLEVEKAFHPFIAGPYNRLVGEIMQETGTRINIPPPSV-----NRTEIV 269
Query: 491 --GDKENV 508
G+KE +
Sbjct: 270 FTGEKEQL 277
Score = 59.7 bits (143), Expect = 1e-08
Identities = 49/188 (26%), Positives = 88/188 (46%), Gaps = 2/188 (1%)
Frame = +2
Query: 8 DFISIKGPRANLIDAKAGLDELIVVWENEKQDRIARNFENQVPVPIVFHRKLIGQRGANI 187
D + I+GP +++ AK L L EKQ ++F + +H+ LIG+ G I
Sbjct: 698 DTVVIRGPSSDVEKAKKQLLHLA----EEKQ---TKSFTVDIRAKPEYHKFLIGKGGGKI 750
Query: 188 EMFRSKFNVSIQIPDQNSKSEE-ITIRGYEEDVKKAEDELLSMVDRWKAQVIEELHIPRD 364
R I P K ++ ITI G E+ V++A+ EL +++ + V + + +
Sbjct: 751 RKVRDSTGARIIFPAAEDKDQDLITIIGKEDAVREAQKELEALIQNLENVVEDYMLVDPK 810
Query: 365 VHPQLIGSRGSALRKLREQY-NVEINFPSKNVDDDNANRVEVIGDKENVDKCCDILVEKA 541
H + RG LR++ E+Y V ++FP D +V + G K+ C + ++
Sbjct: 811 HHRHFVIRRGQVLREIAEEYGGVMVSFPRSGTQSD---KVTLKGAKD----CVEAAKKRI 863
Query: 542 NELLYEWE 565
E++ + E
Sbjct: 864 QEIIEDLE 871
Score = 50.8 bits (120), Expect = 5e-06
Identities = 47/221 (21%), Positives = 98/221 (44%), Gaps = 15/221 (6%)
Frame = +2
Query: 26 GPRANLIDAKAGLDELIVVWENEKQD----RIARNFENQ--------VPVPIVFHRKLIG 169
G R N+ E++ E E+ RI + +E + V V H+ +IG
Sbjct: 253 GTRINIPPPSVNRTEIVFTGEKEQLAQAVARIKKIYEEKKKKTTTIAVEVKKSQHKYVIG 312
Query: 170 QRGANIEMFRSKFNVSIQIPDQNSKSEEITIRGYEEDVKKAEDELLSMVDRWKAQVIEEL 349
+G +++ + VS++IP +S SE + +RG E + +A E+ + + + + +
Sbjct: 313 PKGNSLQEILERTGVSVEIPPSDSISETVILRGEPEKLGQALTEVYAKANSF---TVSSV 369
Query: 350 HIPRDVHPQLIGSRGSALRKLREQY-NVEINFPSKNVDDDNANRVEVIGDKENVDKCCDI 526
P +H +IG +G L K+ +Q V I F + +++ + G E+V+ +
Sbjct: 370 SAPSWLHRFIIGKKGQNLAKITQQMPKVHIEF------TEGEDKITLEGPTEDVNVAQEQ 423
Query: 527 LVEKANELL--YEWEERNQVREVKNSIKDRENVNSNNLKEK 643
+ +L+ ++ E N + + + N N +K++
Sbjct: 424 IEGMVKDLINRMDYVEINIDHKFHRHLIGKSGANINRIKDQ 464
>sp|Q9Z1A6|VIGLN_RAT Vigilin (High density lipoprotein-binding protein) (HDL-binding
protein)
Length = 1268
Score = 132 bits (333), Expect = 9e-31
Identities = 82/246 (33%), Positives = 132/246 (53%), Gaps = 8/246 (3%)
Frame = +2
Query: 14 ISIKGPRANLIDAKAGLDELIVVWENEKQDRIARNFENQVPVPIVFHRKLIGQRGANIEM 193
I+I G ANL AKAGL + + + E++DR R+F+ V V +H K+IG +GA I
Sbjct: 1018 IAITGLAANLDRAKAGLLDRVKELQAEQEDRALRSFKLSVTVDPKYHPKIIGGKGAVITQ 1077
Query: 194 FRSKFNVSIQIPDQ---NSKSEEITIRGYEEDVKKAEDELLSMVDRWKAQVIEELHIPRD 364
R + +V+IQ PD+ N ++ITI GYE++ + A D +L +V + V E++ +
Sbjct: 1078 IRLEHDVNIQFPDKDDGNQPQDQITITGYEKNTEAARDAILKIVGELEQMVSEDVPLDHR 1137
Query: 365 VHPQLIGSRGSALRKLREQYNVEINFPSKNVDDDNANRVEVIGDKENVDKCCDILVEKAN 544
VH ++IG+RG A+RK+ +++ V+I FP D N V V G ENV++ D ++
Sbjct: 1138 VHARIIGARGKAIRKIMDEFKVDIRFPQSGAPDPNC--VTVTGLPENVEEAIDHILNLEE 1195
Query: 545 ELLYEWEERNQVREVKNSIKDRENVNSNNLKEKGPGFLLAGAPW-----QRVPDASSNVD 709
E L + + ++ E+ K GF++ APW ++ PD SS+ +
Sbjct: 1196 EYLADVVDSEALQVYMKPPAHEES------KAPSKGFVVRDAPWTSNSSEKAPDMSSSEE 1249
Query: 710 FPTIDA 727
PT A
Sbjct: 1250 IPTFGA 1255
Score = 87.0 bits (214), Expect = 6e-17
Identities = 55/186 (29%), Positives = 102/186 (54%), Gaps = 4/186 (2%)
Frame = +2
Query: 8 DFISIKGPRANLIDAKAGLDELIVVWENEKQDRIARNFENQVPVPIVFHRKLIGQRGANI 187
D I+++GP ++ A+ ++ ++ +D I R ++ + FHR LIG+ GANI
Sbjct: 406 DKITLEGPTEDVNVAQEQIEGMV-------KDLINRMDYVEINIDHKFHRHLIGKSGANI 458
Query: 188 EMFRSKFNVSIQIPDQNSKSEEITIRGYEEDVKKAEDELLSMVDRWKAQVIEELHIPRDV 367
+ ++ VS++IP + KS I I G + V++A+ ELL + R + + ++L I +
Sbjct: 459 NRIKDQYKVSVRIPPDSEKSNLIRIEGDPQGVQQAKRELLELASRMENERTKDLIIEQRF 518
Query: 368 HPQLIGSRGSALRKLREQY-NVEINFPSKNVDDDNANRVEVI---GDKENVDKCCDILVE 535
H +IG +G +R++R+++ V INFP D A + E++ G K V+KC + +
Sbjct: 519 HRTIIGQKGERIREIRDKFPEVIINFP------DPAQKSEIVQLRGPKNEVEKCTKYMQK 572
Query: 536 KANELL 553
+L+
Sbjct: 573 MVADLV 578
Score = 79.7 bits (195), Expect = 9e-15
Identities = 51/182 (28%), Positives = 93/182 (51%), Gaps = 2/182 (1%)
Frame = +2
Query: 8 DFISIKGPRANLIDAKAGLDELIVVWENEKQDRIARNFENQVPVPIVFHRKLIGQRGANI 187
+ + ++GP+ + + +++ D + ++ VP+ FH+ +IG+ GANI
Sbjct: 552 EIVQLRGPKNEVEKCTKYMQKMVA-------DLVENSYSISVPIFKQFHKNIIGKGGANI 604
Query: 188 EMFRSKFNVSIQIPDQNSKSEEITIRGYEEDVKKAEDELLSMVDRWKAQVIE-ELHIPRD 364
+ R + N I +P +NS SE I I G + + A +LS + + A + E E+ IP
Sbjct: 605 KKIREESNTKIDLPAENSNSETIVITGKRANCEAARSRILS-IQKDLANIAEVEVSIPAK 663
Query: 365 VHPQLIGSRGSALRKLREQY-NVEINFPSKNVDDDNANRVEVIGDKENVDKCCDILVEKA 541
+H LIG++G +R + E+ V I+FP V+ ++ V + G +V+K L+ A
Sbjct: 664 LHNSLIGTKGRLIRSIMEECGGVHIHFP---VEGSGSDTVVIRGPSSDVEKAKKQLLHLA 720
Query: 542 NE 547
E
Sbjct: 721 EE 722
Score = 75.9 bits (185), Expect = 1e-13
Identities = 48/189 (25%), Positives = 90/189 (47%), Gaps = 8/189 (4%)
Frame = +2
Query: 8 DFISIKGPRANLIDAKAGLDELIVVWENEKQDRIARNFENQVPVPIVFHRKLIGQRGANI 187
D I I G + AK L+ L+ V +V VP HR +IGQ+G+ I
Sbjct: 949 DIIVISGRKEKCEAAKEALEALVPV-------------TIEVEVPFDLHRYIIGQKGSGI 995
Query: 188 EMFRSKFNVSIQIPDQNSKSEEITIRGYEEDVKKAEDELLSMVDRWKAQVIE-------- 343
+F V+I +P +S I I G ++ +A+ LL V +A+ +
Sbjct: 996 RKMMDEFEVNIHVPAPELQSHTIAITGLAANLDRAKAGLLDRVKELQAEQEDRALRSFKL 1055
Query: 344 ELHIPRDVHPQLIGSRGSALRKLREQYNVEINFPSKNVDDDNANRVEVIGDKENVDKCCD 523
+ + HP++IG +G+ + ++R +++V I FP K+ + +++ + G ++N + D
Sbjct: 1056 SVTVDPKYHPKIIGGKGAVITQIRLEHDVNIQFPDKDDGNQPQDQITITGYEKNTEAARD 1115
Query: 524 ILVEKANEL 550
+++ EL
Sbjct: 1116 AILKIVGEL 1124
Score = 64.3 bits (155), Expect = 4e-10
Identities = 47/167 (28%), Positives = 80/167 (47%), Gaps = 2/167 (1%)
Frame = +2
Query: 14 ISIKGPRANLIDAKAGLDELIVVWENEKQDRIARNFENQVPVPIVFHRKLIGQRGANIEM 193
I I G RAN A++ + + Q +A E +V +P H LIG +G I
Sbjct: 627 IVITGKRANCEAARSRILSI--------QKDLANIAEVEVSIPAKLHNSLIGTKGRLIRS 678
Query: 194 FRSKFN-VSIQIPDQNSKSEEITIRGYEEDVKKAEDELLSMVDRWKAQVIE-ELHIPRDV 367
+ V I P + S S+ + IRG DV+KA+ +LL + + + + ++ +
Sbjct: 679 IMEECGGVHIHFPVEGSGSDTVVIRGPSSDVEKAKKQLLHLAEEKQTKSFTVDIRAKPEY 738
Query: 368 HPQLIGSRGSALRKLREQYNVEINFPSKNVDDDNANRVEVIGDKENV 508
H LIG G +RK+R+ I FP+ +D + + + +IG ++ V
Sbjct: 739 HKFLIGKGGGKIRKVRDSTGARIIFPA--AEDKDQDLITIIGKEDAV 783
Score = 63.5 bits (153), Expect = 7e-10
Identities = 38/149 (25%), Positives = 78/149 (52%), Gaps = 1/149 (0%)
Frame = +2
Query: 8 DFISIKGPRANLIDAKAGLDELIVVWENEKQDRIARNFENQVPVPIVFHRKLIGQRGANI 187
D I+I G + +A+ L+ LI +N +D + V HR + +RG +
Sbjct: 772 DLITIIGKEDAVREAQKELEALIQNLDNVVEDYML--------VDPRHHRHFVIRRGQVL 823
Query: 188 EMFRSKFN-VSIQIPDQNSKSEEITIRGYEEDVKKAEDELLSMVDRWKAQVIEELHIPRD 364
++ V + P ++S+++T++G ++ V+ A+ + +++ +AQV E IP+
Sbjct: 824 REIAEEYGGVMVSFPRSGTQSDKVTLKGAKDCVEAAKKRIQEIIEDLEAQVTLECAIPQK 883
Query: 365 VHPQLIGSRGSALRKLREQYNVEINFPSK 451
H ++G +GS ++++ YNV+I FP +
Sbjct: 884 FHRSVMGPKGSRIQQITRDYNVQIKFPDR 912
Score = 63.2 bits (152), Expect = 9e-10
Identities = 36/128 (28%), Positives = 64/128 (50%), Gaps = 2/128 (1%)
Frame = +2
Query: 131 VPVPIVFHRKLIGQRGANIEMFRSKFNVSIQIPDQNSKSEEITIRGYEEDVKKAEDELLS 310
VP+P HR +IG+ G ++ K IQIP + S +I I G +E ++KA E+L
Sbjct: 155 VPIPKEHHRFVIGKNGEKLQDLELKTATKIQIPRPDDPSNQIKITGTKEGIEKARHEVLL 214
Query: 311 MVDRWKAQVIEELHIPRDVHPQLIGSRGSALRKLREQYNVEINFPSKNVDDDNANRVEVI 490
+ + ++ L + + HP + G + ++ ++ IN P +V NR E++
Sbjct: 215 ISAEQDKRAVKRLEVEKAFHPFIAGPYNRLVGEIMQETGTRINIPPPSV-----NRTEIV 269
Query: 491 --GDKENV 508
G+KE +
Sbjct: 270 FTGEKEQL 277
Score = 58.5 bits (140), Expect = 2e-08
Identities = 49/188 (26%), Positives = 87/188 (46%), Gaps = 2/188 (1%)
Frame = +2
Query: 8 DFISIKGPRANLIDAKAGLDELIVVWENEKQDRIARNFENQVPVPIVFHRKLIGQRGANI 187
D + I+GP +++ AK L L EKQ ++F + +H+ LIG+ G I
Sbjct: 698 DTVVIRGPSSDVEKAKKQLLHLA----EEKQ---TKSFTVDIRAKPEYHKFLIGKGGGKI 750
Query: 188 EMFRSKFNVSIQIPDQNSKSEE-ITIRGYEEDVKKAEDELLSMVDRWKAQVIEELHIPRD 364
R I P K ++ ITI G E+ V++A+ EL +++ V + + +
Sbjct: 751 RKVRDSTGARIIFPAAEDKDQDLITIIGKEDAVREAQKELEALIQNLDNVVEDYMLVDPR 810
Query: 365 VHPQLIGSRGSALRKLREQY-NVEINFPSKNVDDDNANRVEVIGDKENVDKCCDILVEKA 541
H + RG LR++ E+Y V ++FP D +V + G K+ C + ++
Sbjct: 811 HHRHFVIRRGQVLREIAEEYGGVMVSFPRSGTQSD---KVTLKGAKD----CVEAAKKRI 863
Query: 542 NELLYEWE 565
E++ + E
Sbjct: 864 QEIIEDLE 871
Score = 50.1 bits (118), Expect = 8e-06
Identities = 47/221 (21%), Positives = 97/221 (43%), Gaps = 15/221 (6%)
Frame = +2
Query: 26 GPRANLIDAKAGLDELIVVWENEKQD----RIARNFENQ--------VPVPIVFHRKLIG 169
G R N+ E++ E E+ RI + +E + V V H+ +IG
Sbjct: 253 GTRINIPPPSVNRTEIVFTGEKEQLAQAVARIKKIYEEKKKKTTTIAVEVKKSQHKYVIG 312
Query: 170 QRGANIEMFRSKFNVSIQIPDQNSKSEEITIRGYEEDVKKAEDELLSMVDRWKAQVIEEL 349
+G +++ + VS++IP +S SE + +RG E + +A E+ + + + + +
Sbjct: 313 PKGNSLQEILERTGVSVEIPPSDSISETVILRGEPEKLGQALTEVYAKANSF---TVSSV 369
Query: 350 HIPRDVHPQLIGSRGSALRKLREQY-NVEINFPSKNVDDDNANRVEVIGDKENVDKCCDI 526
P +H +IG +G L K+ Q V I F + +++ + G E+V+ +
Sbjct: 370 SAPSWLHRFIIGKKGQNLAKITHQMPKVHIEF------TEGEDKITLEGPTEDVNVAQEQ 423
Query: 527 LVEKANELL--YEWEERNQVREVKNSIKDRENVNSNNLKEK 643
+ +L+ ++ E N + + + N N +K++
Sbjct: 424 IEGMVKDLINRMDYVEINIDHKFHRHLIGKSGANINRIKDQ 464
>sp|P06105|SC160_YEAST Protein SCP160 (Protein HX)
Length = 1222
Score = 73.2 bits (178), Expect = 8e-13
Identities = 39/114 (34%), Positives = 63/114 (55%), Gaps = 6/114 (5%)
Frame = +2
Query: 131 VPVPIVFHRKLIGQRGANIEMFRSKFNVSIQIPDQNS------KSEEITIRGYEEDVKKA 292
V +P +LIG +G+N++ R KF I IP++ + K+ E+T+ G E ++ A
Sbjct: 639 VNIPANSVARLIGNKGSNLQQIREKFACQIDIPNEENNNASKDKTVEVTLTGLEYNLTHA 698
Query: 293 EDELLSMVDRWKAQVIEELHIPRDVHPQLIGSRGSALRKLREQYNVEINFPSKN 454
+ L + +W + +EL +P H LIG G+ +L+E+YNV INFP N
Sbjct: 699 KKYLAAEAKKWADIITKELIVPVKFHGSLIGPHGTYRNRLQEKYNVFINFPRDN 752
Score = 69.3 bits (168), Expect = 1e-11
Identities = 46/174 (26%), Positives = 89/174 (51%), Gaps = 7/174 (4%)
Frame = +2
Query: 14 ISIKGPRANLIDAKAGLDELIVVWENEKQDRIARNFENQV-PVPIVFHRKLIGQRGANIE 190
+ I G R N+ DA ++ ++ A +F +V + +H+ ++G G +
Sbjct: 835 LEITGSRQNIKDAAKRVESIVAE---------ASDFVTEVLKIDHKYHKSIVGSGGHILR 885
Query: 191 MFRSKF------NVSIQIPDQNSKSEEITIRGYEEDVKKAEDELLSMVDRWKAQVIEELH 352
SK N S+ IP+ +S++++IT++G ++ VKK +E+ +V + V + +
Sbjct: 886 EIISKAGGEEIRNKSVDIPNADSENKDITVQGPQKFVKKVVEEINKIVKDAENSVTKTID 945
Query: 353 IPRDVHPQLIGSRGSALRKLREQYNVEINFPSKNVDDDNANRVEVIGDKENVDK 514
IP + LIG G R+L ++N+ + P+K DD + ++ + G ENV+K
Sbjct: 946 IPAERKGALIGPGGIVRRQLESEFNINLFVPNK---DDPSGKITITGAPENVEK 996
Score = 57.4 bits (137), Expect = 5e-08
Identities = 37/121 (30%), Positives = 69/121 (57%), Gaps = 4/121 (3%)
Frame = +2
Query: 92 EKQDRIARNFENQVP--VPIVFHRK--LIGQRGANIEMFRSKFNVSIQIPDQNSKSEEIT 259
E+ ++I ++ EN V + I RK LIG G S+FN+++ +P+++ S +IT
Sbjct: 927 EEINKIVKDAENSVTKTIDIPAERKGALIGPGGIVRRQLESEFNINLFVPNKDDPSGKIT 986
Query: 260 IRGYEEDVKKAEDELLSMVDRWKAQVIEELHIPRDVHPQLIGSRGSALRKLREQYNVEIN 439
I G E+V+KAE ++L+ + R E+ +P ++ + + RG+ ++KLR +V +
Sbjct: 987 ITGAPENVEKAEKKILNEIIR--ENFDREVDVPASIY-EYVSERGAFIQKLRMDLSVNVR 1043
Query: 440 F 442
F
Sbjct: 1044 F 1044
Score = 43.9 bits (102), Expect = 6e-04
Identities = 24/91 (26%), Positives = 55/91 (60%)
Frame = +2
Query: 218 IQIPDQNSKSEEITIRGYEEDVKKAEDELLSMVDRWKAQVIEELHIPRDVHPQLIGSRGS 397
+QI + ++T+RG E+ K A S+++ ++ ++IP + +LIG++GS
Sbjct: 596 LQIKLHTPEENQLTVRGDEKAAKAANKIFESILNSPSSKSKMTVNIPANSVARLIGNKGS 655
Query: 398 ALRKLREQYNVEINFPSKNVDDDNANRVEVI 490
L+++RE++ +I+ P N +++NA++ + +
Sbjct: 656 NLQQIREKFACQIDIP--NEENNNASKDKTV 684
Score = 31.2 bits (69), Expect = 3.7
Identities = 19/54 (35%), Positives = 32/54 (59%), Gaps = 1/54 (1%)
Frame = +2
Query: 377 LIGSRGSALRKLREQYNVEINFPSKNVDDDNANRVEVI-GDKENVDKCCDILVE 535
++G GS ++K+RE +V IN P K+ D N V I G K V+K +++++
Sbjct: 1168 IVGPGGSNIKKIREAADVIINVPRKS---DKVNDVVYIRGTKAGVEKAGEMVLK 1218
Score = 30.0 bits (66), Expect = 8.3
Identities = 34/153 (22%), Positives = 67/153 (43%), Gaps = 3/153 (1%)
Frame = +2
Query: 14 ISIKGPRANLIDAKAGLDELIVVWENEKQDRIARNFENQVPVPIVFHRKLIGQRG---AN 184
+S+ G ++ AKA + L +V E K I E++ +P + + G
Sbjct: 233 VSLFGDFESVNLAKAKI--LAIVKEETKNATIKLVVEDEKYLPYIDVSEFASDEGDEEVK 290
Query: 185 IEMFRSKFNVSIQIPDQNSKSEEITIRGYEEDVKKAEDELLSMVDRWKAQVIEELHIPRD 364
++ ++ ++ I P + +K+ + +I+ Y +KK L S +D K ++ + D
Sbjct: 291 VQFYKKSGDIVILGpreKAKATKTSIQDY---LKK----LASNLDEEKVKIPSKFQFLID 343
Query: 365 VHPQLIGSRGSALRKLREQYNVEINFPSKNVDD 463
+L+E+YNV + FPS D+
Sbjct: 344 AE------------ELKEKYNVIVTFPSTPDDE 364
>sp|Q80VL1|TDRKH_MOUSE Tudor and KH domain-containing protein
Length = 560
Score = 42.7 bits (99), Expect = 0.001
Identities = 41/215 (19%), Positives = 97/215 (45%), Gaps = 6/215 (2%)
Frame = +2
Query: 116 NFENQVPVPIVFHRKLIGQRGANIEMFRSKFNVSIQIPDQNSKSEEI-TIRGYEEDVKKA 292
+ E ++ VP + +IG++GANI+ R + I + ++ E + I G+ V KA
Sbjct: 52 DIEIEMRVPQEAVKLIIGRQGANIKQLRKQTGARIDVDTEDVGDERVLLISGFPVQVCKA 111
Query: 293 EDELLSMVDRWKAQVIEELHIPRDVHPQLIGSRGSALRKLREQYNVEINFPSKNVDDDNA 472
+ + ++ V E+L +P+ ++IG G +R + + +I ++
Sbjct: 112 KAAIHQILTE-NTPVFEQLSVPQRSVGRIIGRGGETIRSICKASGAKITCDKESEGTLLL 170
Query: 473 NR-VEVIGDKENVDKCCDILVEKANELLYEWEERNQV-REVKNSIKDRENVNSNNLKEKG 646
+R +++ G ++ V +++EK +E + E R ++ + + ++ ++ +
Sbjct: 171 SRLIKISGTQKEVAAAKHLILEKVSE---DEELRKRIAHSAETRVPRKQPISVRREEVTE 227
Query: 647 PGFLLAGAPWQRVPDA---SSNVDFPTIDANGDKI 742
PG A W+ + ++ ++ P GD +
Sbjct: 228 PGGAGEAALWKNTNSSMGPATPLEVPLRKGGGDMV 262
>sp|Q9Y2W6|TDRKH_HUMAN Tudor and KH domain-containing protein
Length = 606
Score = 41.6 bits (96), Expect = 0.003
Identities = 32/146 (21%), Positives = 71/146 (48%), Gaps = 2/146 (1%)
Frame = +2
Query: 116 NFENQVPVPIVFHRKLIGQRGANIEMFRSKFNVSIQIPDQNSKSEEI-TIRGYEEDVKKA 292
+ E ++ VP + +IG++GANI+ R + I + ++ E + I G+ V KA
Sbjct: 52 DIEIEMRVPQEAVKLIIGRQGANIKQLRKQTGARIDVDTEDVGDERVLLISGFPVQVCKA 111
Query: 293 EDELLSMVDRWKAQVIEELHIPRDVHPQLIGSRGSALRKLREQYNVEINFPSKNVDDDNA 472
+ + ++ V E+L +P+ ++IG G +R + + +I ++
Sbjct: 112 KAAIHQILTE-NTPVSEQLSVPQRSVGRIIGRGGETIRSICKASGAKITCDKESEGTLLL 170
Query: 473 NR-VEVIGDKENVDKCCDILVEKANE 547
+R +++ G ++ V +++EK +E
Sbjct: 171 SRLIKISGTQKEVAAAKHLILEKVSE 196
>sp|P57722|PCBP3_MOUSE Poly(rC)-binding protein 3 (Alpha-CP3)
Length = 339
Score = 40.8 bits (94), Expect = 0.005
Identities = 32/141 (22%), Positives = 60/141 (42%), Gaps = 16/141 (11%)
Frame = +2
Query: 161 LIGQRGANIEMFRSKFNVSIQIPDQNSKSEEITIRGYEEDVKKA---------EDELLSM 313
+IG++G ++ R + I I + N +TI G + + KA ED + SM
Sbjct: 28 IIGKKGETVKKMREESGARINISEGNCPERIVTITGPTDAIFKAFAMIAYKFEEDIINSM 87
Query: 314 VDR---WKAQVIEELHIPRDVHPQLIGSRGSALRKLREQYNVEINFPSKNVDDDNANRVE 484
+ K V L +P LIG GS ++++RE ++ + + V
Sbjct: 88 SNSPATSKPPVTLRLVVPASQCGSLIGKGGSKIKEIRESTGAQVQVAGDMLPNSTERAVT 147
Query: 485 VIGDKENVDKC----CDILVE 535
+ G + + +C C +++E
Sbjct: 148 ISGTPDAIIQCVKQICVVMLE 168
>sp|P57721|PCBP3_HUMAN Poly(rC)-binding protein 3 (Alpha-CP3)
Length = 339
Score = 40.8 bits (94), Expect = 0.005
Identities = 32/141 (22%), Positives = 60/141 (42%), Gaps = 16/141 (11%)
Frame = +2
Query: 161 LIGQRGANIEMFRSKFNVSIQIPDQNSKSEEITIRGYEEDVKKA---------EDELLSM 313
+IG++G ++ R + I I + N +TI G + + KA ED + SM
Sbjct: 28 IIGKKGETVKKMREESGARINISEGNCPERIVTITGPTDAIFKAFAMIAYKFEEDIINSM 87
Query: 314 VDR---WKAQVIEELHIPRDVHPQLIGSRGSALRKLREQYNVEINFPSKNVDDDNANRVE 484
+ K V L +P LIG GS ++++RE ++ + + V
Sbjct: 88 SNSPATSKPPVTLRLVVPASQCGSLIGKGGSKIKEIRESTGAQVQVAGDMLPNSTERAVT 147
Query: 485 VIGDKENVDKC----CDILVE 535
+ G + + +C C +++E
Sbjct: 148 ISGTPDAIIQCVKQICVVMLE 168
>sp|Q01570|SECA_PAVLU Preprotein translocase secA subunit
Length = 891
Score = 38.9 bits (89), Expect = 0.018
Identities = 50/186 (26%), Positives = 82/186 (44%), Gaps = 20/186 (10%)
Frame = +2
Query: 146 VFHRKLIGQRGANI---EMFRSKFNVSIQIPDQNSKSEEITIRGYEEDVKKAEDELLSMV 316
+F++KL G G + + F+ +N+S+ N K I +EDV S+
Sbjct: 357 LFYKKLSGMTGTALTEAKEFKKIYNLSVDCVPINKKVNRID----KEDVVYK-----SLY 407
Query: 317 DRWKAQVIEELHIPRDVHPQLIGS----RGSALRKLREQYNVEINFPSKNVDDDNANRVE 484
+WKA + E L I P LIG+ + L ++YN++ + + ++ AN E
Sbjct: 408 AKWKAVLYESLSIHEQGRPLLIGTSNVKNSEIVSGLLKEYNIKHSLLNAK-PENAANESE 466
Query: 485 VI---GDKENV-------DKCCDILVEKANELLYEWEERNQVREVKNSIKDR---ENVNS 625
+I G K +V + DIL+ + L + E R R + S+ D +N
Sbjct: 467 IIAQAGRKGSVTIATNMAGRGTDILLGGNPDFLTKGELRYIFRSIVLSLDDMTVPKNELI 526
Query: 626 NNLKEK 643
NNLK K
Sbjct: 527 NNLKYK 532
Database: Non-redundant SwissProt sequences
Posted date: Dec 6, 2005 7:40 AM
Number of letters in database: 68,354,980
Number of sequences in database: 184,735
Database: swissprot.01
Posted date: Dec 6, 2005 8:18 AM
Number of letters in database: 66,202,850
Number of sequences in database: 184,431
Lambda K H
0.318 0.134 0.401
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 85,842,793
Number of Sequences: 369166
Number of extensions: 1623994
Number of successful extensions: 5845
Number of sequences better than 10.0: 10
Number of HSP's better than 10.0 without gapping: 5538
Number of HSP's successfully gapped in prelim test: 0
Number of HSP's that attempted gapping in prelim test: 0
Number of HSP's gapped (non-prelim): 5783
length of database: 68,354,980
effective HSP length: 109
effective length of database: 48,218,865
effective search space used: 8148988185
frameshift window, decay const: 40, 0.1
T: 12
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)