Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= Dr_sW_004_N13
(864 letters)
Database: Non-redundant SwissProt sequences
184,735 sequences; 68,354,980 total letters
Score E
Sequences producing significant alignments: (bits) Value
sp|Q9Y561|LRP12_HUMAN Low-density lipoprotein receptor-rela... 43 0.001
sp|Q8BUJ9|LRP12_MOUSE Low-density lipoprotein receptor-rela... 43 0.001
sp|Q9BE74|LRP12_MACFA Low-density lipoprotein receptor-rela... 43 0.001
sp|O75074|LRP3_HUMAN Low-density lipoprotein receptor-relat... 41 0.005
sp|O88204|LRP3_RAT Low-density lipoprotein receptor-related... 41 0.005
sp|O75096|LRP4_HUMAN Low-density lipoprotein receptor-relat... 39 0.024
sp|Q9Y5Q5|CORIN_HUMAN Atrial natriuteric peptide-converting... 38 0.032
sp|Q28832|LDLR_PIG Low-density lipoprotein receptor (LDL re... 38 0.032
sp|Q7Z4F1|LRP10_HUMAN Low-density lipoprotein receptor-rela... 38 0.042
sp|Q98930|SORL_CHICK Sortilin-related receptor (Sorting pro... 37 0.054
>sp|Q9Y561|LRP12_HUMAN Low-density lipoprotein receptor-related protein 12 precursor
(Suppressor of tumorigenicity protein 7)
Length = 859
Score = 43.1 bits (100), Expect = 0.001
Identities = 26/101 (25%), Positives = 41/101 (40%)
Frame = +3
Query: 12 RCIIESLRCDGTITCRDGSDEHNCDMILPYXXXXXXXXXXXXXXXXXXXXXXXXGFVCIC 191
RC+ ES CD C DGSDE NC +I+P C C
Sbjct: 462 RCVFESWVCDSQDDCGDGSDEENCPVIVP-----TRVITAAVIGSLICGLLLVIALGCTC 516
Query: 192 RLHKMRILTTRNLARRRGYMSQYDSSIQQLIDEQMRRGPPP 314
+L+ +R+ R+ +++ + ++ E +RR PP
Sbjct: 517 KLYSLRMFERRS----------FETQLSRVEAELLRREAPP 547
Score = 35.8 bits (81), Expect = 0.16
Identities = 14/25 (56%), Positives = 18/25 (72%)
Frame = +3
Query: 15 CIIESLRCDGTITCRDGSDEHNCDM 89
C+ ESL+CDG I C D DE +CD+
Sbjct: 232 CLPESLKCDGNIDCLDLGDEIDCDV 256
Score = 31.6 bits (70), Expect = 3.0
Identities = 13/25 (52%), Positives = 14/25 (56%)
Frame = +3
Query: 15 CIIESLRCDGTITCRDGSDEHNCDM 89
C E RCDG C +G DE NC M
Sbjct: 388 CYTEQQRCDGYWHCPNGRDETNCTM 412
>sp|Q8BUJ9|LRP12_MOUSE Low-density lipoprotein receptor-related protein 12 precursor
Length = 858
Score = 43.1 bits (100), Expect = 0.001
Identities = 26/101 (25%), Positives = 41/101 (40%)
Frame = +3
Query: 12 RCIIESLRCDGTITCRDGSDEHNCDMILPYXXXXXXXXXXXXXXXXXXXXXXXXGFVCIC 191
RC+ ES CD C DGSDE NC +I+P C C
Sbjct: 462 RCVFESWVCDSQDDCGDGSDEENCPVIVP-----TRVITAAVIGSLICGLLLVIALGCTC 516
Query: 192 RLHKMRILTTRNLARRRGYMSQYDSSIQQLIDEQMRRGPPP 314
+L+ +R+ R+ +++ + ++ E +RR PP
Sbjct: 517 KLYSLRMFERRS----------FETQLSRVEAELLRREAPP 547
Score = 37.4 bits (85), Expect = 0.054
Identities = 15/25 (60%), Positives = 18/25 (72%)
Frame = +3
Query: 15 CIIESLRCDGTITCRDGSDEHNCDM 89
C+ ESL+CDG I C D DE +CDM
Sbjct: 232 CLPESLKCDGNIDCLDLGDEIDCDM 256
Score = 31.2 bits (69), Expect = 3.9
Identities = 13/25 (52%), Positives = 14/25 (56%)
Frame = +3
Query: 15 CIIESLRCDGTITCRDGSDEHNCDM 89
C E RCDG C +G DE NC M
Sbjct: 388 CYTEQQRCDGYWHCPNGRDEINCTM 412
>sp|Q9BE74|LRP12_MACFA Low-density lipoprotein receptor-related protein 12
Length = 701
Score = 43.1 bits (100), Expect = 0.001
Identities = 26/101 (25%), Positives = 41/101 (40%)
Frame = +3
Query: 12 RCIIESLRCDGTITCRDGSDEHNCDMILPYXXXXXXXXXXXXXXXXXXXXXXXXGFVCIC 191
RC+ ES CD C DGSDE NC +I+P C C
Sbjct: 304 RCVFESWVCDSQDDCGDGSDEENCPVIVP-----TRVITAAVIGSLICGLLLVIALGCTC 358
Query: 192 RLHKMRILTTRNLARRRGYMSQYDSSIQQLIDEQMRRGPPP 314
+L+ +R+ R+ +++ + ++ E +RR PP
Sbjct: 359 KLYSLRMFERRS----------FETQLSRVEAELLRREAPP 389
Score = 36.6 bits (83), Expect = 0.093
Identities = 14/25 (56%), Positives = 18/25 (72%)
Frame = +3
Query: 15 CIIESLRCDGTITCRDGSDEHNCDM 89
C+ ESL+CDG I C D DE +CD+
Sbjct: 74 CLAESLKCDGNIDCLDLGDEIDCDV 98
Score = 31.2 bits (69), Expect = 3.9
Identities = 13/25 (52%), Positives = 14/25 (56%)
Frame = +3
Query: 15 CIIESLRCDGTITCRDGSDEHNCDM 89
C E RCDG C +G DE NC M
Sbjct: 230 CYTEQQRCDGYWHCPNGRDEINCTM 254
>sp|O75074|LRP3_HUMAN Low-density lipoprotein receptor-related protein 3 precursor
(hLRp105)
Length = 770
Score = 40.8 bits (94), Expect = 0.005
Identities = 16/28 (57%), Positives = 19/28 (67%)
Frame = +3
Query: 15 CIIESLRCDGTITCRDGSDEHNCDMILP 98
CI E+ RCDG C+DGSDEH C +P
Sbjct: 467 CIFETWRCDGQEDCQDGSDEHGCLAAVP 494
Score = 33.9 bits (76), Expect = 0.60
Identities = 14/25 (56%), Positives = 15/25 (60%)
Frame = +3
Query: 9 TRCIIESLRCDGTITCRDGSDEHNC 83
TRC+ RCDG C DGSDE C
Sbjct: 225 TRCLPVERRCDGLQDCGDGSDEAGC 249
>sp|O88204|LRP3_RAT Low-density lipoprotein receptor-related protein 3 precursor
(rLRp105)
Length = 770
Score = 40.8 bits (94), Expect = 0.005
Identities = 16/28 (57%), Positives = 19/28 (67%)
Frame = +3
Query: 15 CIIESLRCDGTITCRDGSDEHNCDMILP 98
CI E+ RCDG C+DGSDEH C +P
Sbjct: 467 CIFETWRCDGQEDCQDGSDEHGCLAAVP 494
Score = 36.2 bits (82), Expect = 0.12
Identities = 15/25 (60%), Positives = 16/25 (64%)
Frame = +3
Query: 9 TRCIIESLRCDGTITCRDGSDEHNC 83
TRC+ RCDGT C DGSDE C
Sbjct: 225 TRCLPVERRCDGTQDCGDGSDEAGC 249
>sp|O75096|LRP4_HUMAN Low-density lipoprotein receptor-related protein 4 precursor
(Multiple epidermal growth factor-like domains 7)
Length = 1950
Score = 38.5 bits (88), Expect = 0.024
Identities = 15/28 (53%), Positives = 17/28 (60%)
Frame = +3
Query: 15 CIIESLRCDGTITCRDGSDEHNCDMILP 98
CI E CDG C+DGSDE NC +P
Sbjct: 205 CIAEHWYCDGDTDCKDGSDEENCPSAVP 232
Score = 35.4 bits (80), Expect = 0.21
Identities = 14/25 (56%), Positives = 16/25 (64%)
Frame = +3
Query: 12 RCIIESLRCDGTITCRDGSDEHNCD 86
RC+ S RCDG C D SDE NC+
Sbjct: 326 RCVRLSWRCDGEDDCADNSDEENCE 350
Score = 32.0 bits (71), Expect = 2.3
Identities = 13/29 (44%), Positives = 16/29 (55%)
Frame = +3
Query: 12 RCIIESLRCDGTITCRDGSDEHNCDMILP 98
RCI++ CDG C D SDE +C P
Sbjct: 247 RCILDIYHCDGDDDCGDWSDESDCSSHQP 275
Score = 32.0 bits (71), Expect = 2.3
Identities = 13/23 (56%), Positives = 13/23 (56%)
Frame = +3
Query: 15 CIIESLRCDGTITCRDGSDEHNC 83
CI RCDG C D SDE NC
Sbjct: 288 CINAGWRCDGDADCDDQSDERNC 310
Score = 30.0 bits (66), Expect = 8.7
Identities = 12/24 (50%), Positives = 14/24 (58%)
Frame = +3
Query: 12 RCIIESLRCDGTITCRDGSDEHNC 83
+CI S CDG C D SDE +C
Sbjct: 127 KCIRRSWVCDGDNDCEDDSDEQDC 150
>sp|Q9Y5Q5|CORIN_HUMAN Atrial natriuteric peptide-converting enzyme (pro-ANP-converting
enzyme) (Corin) (Heart-specific serine proteinase ATC2)
(Transmembrane protease, serine 10)
Length = 1042
Score = 38.1 bits (87), Expect = 0.032
Identities = 14/27 (51%), Positives = 19/27 (70%)
Frame = +3
Query: 12 RCIIESLRCDGTITCRDGSDEHNCDMI 92
+CI + +CDG C+DGSDE NC +I
Sbjct: 391 QCIPSTFQCDGDEDCKDGSDEENCSVI 417
Score = 35.8 bits (81), Expect = 0.16
Identities = 13/24 (54%), Positives = 16/24 (66%)
Frame = +3
Query: 12 RCIIESLRCDGTITCRDGSDEHNC 83
+C++ S RCDG C D SDE NC
Sbjct: 591 QCVLASRRCDGQADCDDDSDEENC 614
Score = 32.7 bits (73), Expect = 1.3
Identities = 14/25 (56%), Positives = 16/25 (64%)
Frame = +3
Query: 12 RCIIESLRCDGTITCRDGSDEHNCD 86
+C+ SL CDG C D SDE NCD
Sbjct: 317 KCLNYSLVCDGYDDCGDLSDEQNCD 341
Score = 30.0 bits (66), Expect = 8.7
Identities = 11/23 (47%), Positives = 13/23 (56%)
Frame = +3
Query: 15 CIIESLRCDGTITCRDGSDEHNC 83
C+ L CDG C D SDE +C
Sbjct: 667 CVSRDLWCDGEADCSDSSDEWDC 689
>sp|Q28832|LDLR_PIG Low-density lipoprotein receptor (LDL receptor)
Length = 811
Score = 38.1 bits (87), Expect = 0.032
Identities = 15/25 (60%), Positives = 17/25 (68%)
Frame = +3
Query: 15 CIIESLRCDGTITCRDGSDEHNCDM 89
CI S RCDG C+D SDE NCD+
Sbjct: 180 CIHSSWRCDGDTDCKDKSDEENCDV 204
Score = 36.6 bits (83), Expect = 0.093
Identities = 15/24 (62%), Positives = 16/24 (66%)
Frame = +3
Query: 12 RCIIESLRCDGTITCRDGSDEHNC 83
RCI ES RCDG C +GSDE C
Sbjct: 50 RCIPESWRCDGQQDCENGSDEEGC 73
>sp|Q7Z4F1|LRP10_HUMAN Low-density lipoprotein receptor-related protein 10 precursor
Length = 713
Score = 37.7 bits (86), Expect = 0.042
Identities = 14/29 (48%), Positives = 19/29 (65%)
Frame = +3
Query: 12 RCIIESLRCDGTITCRDGSDEHNCDMILP 98
+C+ E+ CDG C DGSDE +C +LP
Sbjct: 410 KCVYETWVCDGQPDCADGSDEWDCSYVLP 438
Score = 35.4 bits (80), Expect = 0.21
Identities = 13/24 (54%), Positives = 17/24 (70%)
Frame = +3
Query: 12 RCIIESLRCDGTITCRDGSDEHNC 83
RC E+ RCDG+ C DG+DE +C
Sbjct: 330 RCYSEAQRCDGSWDCADGTDEEDC 353
Score = 33.1 bits (74), Expect = 1.0
Identities = 13/24 (54%), Positives = 14/24 (58%)
Frame = +3
Query: 12 RCIIESLRCDGTITCRDGSDEHNC 83
RC+ RCDG C DGSDE C
Sbjct: 151 RCVSAVQRCDGVDACGDGSDEAGC 174
>sp|Q98930|SORL_CHICK Sortilin-related receptor (Sorting protein-related receptor
containing LDLR class A repeats) (SorLA) (SorLA-1)
(Low-density lipoprotein receptor relative with 11
ligand-binding repeats) (LDLR relative with 11
ligand-binding repeats) (LR11)
Length = 1592
Score = 37.4 bits (85), Expect = 0.054
Identities = 13/23 (56%), Positives = 17/23 (73%)
Frame = +3
Query: 15 CIIESLRCDGTITCRDGSDEHNC 83
C++ + RCDG + C DGSDE NC
Sbjct: 1433 CLLATERCDGYLDCSDGSDERNC 1455
Score = 32.7 bits (73), Expect = 1.3
Identities = 15/25 (60%), Positives = 15/25 (60%)
Frame = +3
Query: 15 CIIESLRCDGTITCRDGSDEHNCDM 89
CI S RCD CRD SDE NC M
Sbjct: 1077 CIRLSWRCDDDNDCRDWSDEANCTM 1101
Score = 32.3 bits (72), Expect = 1.8
Identities = 12/21 (57%), Positives = 15/21 (71%)
Frame = +3
Query: 12 RCIIESLRCDGTITCRDGSDE 74
+C+ S+ CDG I C DGSDE
Sbjct: 1195 QCLSHSMVCDGDIQCEDGSDE 1215
Score = 32.3 bits (72), Expect = 1.8
Identities = 12/24 (50%), Positives = 16/24 (66%)
Frame = +3
Query: 12 RCIIESLRCDGTITCRDGSDEHNC 83
+CI RCDG C+DG+DE +C
Sbjct: 1390 KCIPNWKRCDGRRDCQDGTDERSC 1413
Score = 30.8 bits (68), Expect = 5.1
Identities = 12/27 (44%), Positives = 16/27 (59%)
Frame = +3
Query: 15 CIIESLRCDGTITCRDGSDEHNCDMIL 95
CI S C+G C D SDE +C++ L
Sbjct: 1155 CISTSKHCNGITDCADASDEQDCEIPL 1181
Score = 30.4 bits (67), Expect = 6.7
Identities = 13/23 (56%), Positives = 13/23 (56%)
Frame = +3
Query: 15 CIIESLRCDGTITCRDGSDEHNC 83
CI S CDG C DGSDE C
Sbjct: 1338 CITNSWVCDGYRDCADGSDEDAC 1360
Database: Non-redundant SwissProt sequences
Posted date: Dec 6, 2005 7:40 AM
Number of letters in database: 68,354,980
Number of sequences in database: 184,735
Database: swissprot.01
Posted date: Dec 6, 2005 8:18 AM
Number of letters in database: 66,202,850
Number of sequences in database: 184,431
Lambda K H
0.318 0.134 0.401
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 97,422,646
Number of Sequences: 369166
Number of extensions: 1956051
Number of successful extensions: 5726
Number of sequences better than 10.0: 10
Number of HSP's better than 10.0 without gapping: 4997
Number of HSP's successfully gapped in prelim test: 0
Number of HSP's that attempted gapping in prelim test: 0
Number of HSP's gapped (non-prelim): 5720
length of database: 68,354,980
effective HSP length: 109
effective length of database: 48,218,865
effective search space used: 8582957970
frameshift window, decay const: 40, 0.1
T: 12
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)