Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= Dr_sW_004_M17
(568 letters)
Database: Non-redundant SwissProt sequences
184,735 sequences; 68,354,980 total letters
Score E
Sequences producing significant alignments: (bits) Value
sp|Q94261|CSN7_CAEEL Probable COP9 signalosome complex subu... 94 3e-19
sp|Q9H9Q2|CSN7B_HUMAN COP9 signalosome complex subunit 7b (... 50 4e-06
sp|Q8BV13|CSN7B_MOUSE COP9 signalosome complex subunit 7b (... 50 5e-06
sp|Q9UBW8|CSN7A_HUMAN COP9 signalosome complex subunit 7a (... 49 7e-06
sp|Q94JU3|CSN7_ARATH COP9 signalosome complex subunit 7 (CS... 49 9e-06
sp|Q9CZ04|CSN7A_MOUSE COP9 signalosome complex subunit 7a (... 47 4e-05
sp|Q04062|RPN9_YEAST 26S proteasome regulatory subunit RPN9... 45 1e-04
sp|Q6IQT4|CSN2_BRARE COP9 signalosome complex subunit 2 (Si... 35 0.13
sp|P61201|CSN2_HUMAN COP9 signalosome complex subunit 2 (Si... 34 0.22
sp|Q6IR75|CSN2_XENLA COP9 signalosome complex subunit 2 (Si... 34 0.22
>sp|Q94261|CSN7_CAEEL Probable COP9 signalosome complex subunit 7 (Signalosome subunit 7)
Length = 390
Score = 93.6 bits (231), Expect = 3e-19
Identities = 54/163 (33%), Positives = 97/163 (59%), Gaps = 4/163 (2%)
Frame = +2
Query: 2 VRCIVTALQDPNALTMDQILELKPVQCL--AGEAIHDLLSIFVSGTINDYRKFLDDHPDF 175
+ C+ TA+ DP + + D + L V+ L + + L +F+SGT+ DY++F+ +P F
Sbjct: 213 MECVRTAVVDPKSFSFDHLERLSAVKALKTSDPLMFTALELFISGTLKDYKEFVAKNPKF 272
Query: 176 M-EKYELDKEACLTKIRILSLMTLAAGDTTELSYDTIQKELQLERAE-LEAFVIEAVRQQ 349
+ E ++D+ L KIR+L+LM+LA + E+S D + K+L + E LE FVI+A++
Sbjct: 273 VTEHLKVDETILLKKIRLLTLMSLAE-EKNEISLDELAKQLDILADETLEEFVIDAIQVN 331
Query: 350 AVTCKLDQQNEKVLISGAVPRSFGPDQWTKLYRDLQMWQNNFK 478
A++ K+++ +++S R FG +QW L + L++ N K
Sbjct: 332 AISGKINEMARTLIVSSYQHRRFGTEQWVLLEKRLKVLIANLK 374
>sp|Q9H9Q2|CSN7B_HUMAN COP9 signalosome complex subunit 7b (Signalosome subunit 7b)
(SGN7b) (JAB1-containing signalosome subunit 7b)
Length = 264
Score = 50.1 bits (118), Expect = 4e-06
Identities = 41/155 (26%), Positives = 70/155 (45%), Gaps = 4/155 (2%)
Frame = +2
Query: 11 IVTALQDPNALTMDQILELKPVQCLA---GEAIHDLLSIFVSGTINDYRKFLDDHPDFME 181
I L+ P ++LEL VQ LA A LL++F GT DY + P+
Sbjct: 31 ISQVLEAPGVYVFGELLELANVQELAEGANAAYLQLLNLFAYGTYPDYIANKESLPELST 90
Query: 182 KYELDKEACLTKIRILSLMTLAAGDTTELSYDTIQKELQLERA-ELEAFVIEAVRQQAVT 358
+ K++ L++++LA+ + Y + K+L++ ELE +IEAV +
Sbjct: 91 AQQ-------NKLKHLTIVSLASRMKC-IPYSVLLKDLEMRNLRELEDLIIEAVYTDIIQ 142
Query: 359 CKLDQQNEKVLISGAVPRSFGPDQWTKLYRDLQMW 463
KLDQ+N+ + + + R + + L W
Sbjct: 143 GKLDQRNQLLEVDFCIGRDIRKKDINNIVKTLHEW 177
>sp|Q8BV13|CSN7B_MOUSE COP9 signalosome complex subunit 7b (Signalosome subunit 7b)
(SGN7b) (JAB1-containing signalosome subunit 7b)
Length = 264
Score = 49.7 bits (117), Expect = 5e-06
Identities = 41/155 (26%), Positives = 70/155 (45%), Gaps = 4/155 (2%)
Frame = +2
Query: 11 IVTALQDPNALTMDQILELKPVQCLA---GEAIHDLLSIFVSGTINDYRKFLDDHPDFME 181
I L+ P ++LEL VQ LA A LL++F GT DY + P+
Sbjct: 31 ISQVLEAPGVYVFGELLELANVQELAEGANAAYLQLLNLFAYGTYPDYIANKESLPELSV 90
Query: 182 KYELDKEACLTKIRILSLMTLAAGDTTELSYDTIQKELQLERA-ELEAFVIEAVRQQAVT 358
+ K++ L++++LA+ + Y + K+L++ ELE +IEAV +
Sbjct: 91 AQQ-------NKLKHLTIVSLASRMKC-IPYSVLLKDLEMRNLRELEDLIIEAVYTDIIQ 142
Query: 359 CKLDQQNEKVLISGAVPRSFGPDQWTKLYRDLQMW 463
KLDQ+N+ + + + R + + L W
Sbjct: 143 GKLDQRNQLLEVDFCIGRDIRKKDINNIVKTLHEW 177
>sp|Q9UBW8|CSN7A_HUMAN COP9 signalosome complex subunit 7a (Signalosome subunit 7a)
(SGN7a) (JAB1-containing signalosome subunit 7a) (Dermal
papilla derived protein 10)
sp|Q5R762|CSN7A_PONPY COP9 signalosome complex subunit 7a (Signalosome subunit 7a)
(SGN7a) (JAB1-containing signalosome subunit 7a)
Length = 275
Score = 49.3 bits (116), Expect = 7e-06
Identities = 44/169 (26%), Positives = 77/169 (45%), Gaps = 4/169 (2%)
Frame = +2
Query: 23 LQDPNALTMDQILELKPVQCLAGE---AIHDLLSIFVSGTINDYRKFLDDHPDFMEKYEL 193
L+ P ++L++ V+ LA + LL++F GT DY + P E +
Sbjct: 35 LEAPGVYVFGELLDMPNVRELAESDFASTFRLLTVFAYGTYADYLAEARNLPPLTEAQK- 93
Query: 194 DKEACLTKIRILSLMTLAAGDTTELSYDTIQKELQLERA-ELEAFVIEAVRQQAVTCKLD 370
K+R LS++TLAA + Y + + L L +LE VIEAV + LD
Sbjct: 94 ------NKLRHLSVVTLAA-KVKCIPYAVLLEALALRNVRQLEDLVIEAVYADVLRGSLD 146
Query: 371 QQNEKVLISGAVPRSFGPDQWTKLYRDLQMWQNNFKIITEDLRKLRSDA 517
Q+N+++ + ++ R + + R LQ W +++ + + S A
Sbjct: 147 QRNQRLEVDYSIGRDIQRQDLSAIARTLQEWCVGCEVVLSGIEEQVSRA 195
>sp|Q94JU3|CSN7_ARATH COP9 signalosome complex subunit 7 (CSN complex subunit 7) (FUSCA
protein 5) (FUSCA5)
Length = 260
Score = 48.9 bits (115), Expect = 9e-06
Identities = 47/158 (29%), Positives = 69/158 (43%), Gaps = 5/158 (3%)
Frame = +2
Query: 11 IVTALQDPNALTMDQILELKPVQCLAG--EAIH-DLLSIFVSGTINDYRKFLDDHPDFME 181
I+ A P+ +IL L V L G ++++ DLL +F GT DY+ P
Sbjct: 30 IIEATSHPSLFAFSEILALPNVAQLEGTTDSVYLDLLRLFAHGTWGDYKCNATRLPHLSP 89
Query: 182 KYELDKEACLTKIRILSLMTLAAGDTTELSYDTIQKELQLERA-ELEAFVI-EAVRQQAV 355
+ K++ L+++TLA + L YDT+ EL + ELE F+I E + V
Sbjct: 90 DQ-------ILKLKQLTVLTLAESNKV-LPYDTLMVELDVSNVRELEDFLINECMYAGIV 141
Query: 356 TCKLDQQNEKVLISGAVPRSFGPDQWTKLYRDLQMWQN 469
KLDQ + A R P Q + L W N
Sbjct: 142 RGKLDQLKRCFEVPFAAGRDLRPGQLGNMLHTLSNWLN 179
>sp|Q9CZ04|CSN7A_MOUSE COP9 signalosome complex subunit 7a (Signalosome subunit 7a)
(SGN7a) (JAB1-containing signalosome subunit 7a)
Length = 275
Score = 46.6 bits (109), Expect = 4e-05
Identities = 42/169 (24%), Positives = 77/169 (45%), Gaps = 4/169 (2%)
Frame = +2
Query: 23 LQDPNALTMDQILELKPVQCLAGE---AIHDLLSIFVSGTINDYRKFLDDHPDFMEKYEL 193
L+ P ++L++ V+ LA + LL++F GT DY + P + +
Sbjct: 35 LEAPGVYVFGELLDMPNVRELAESDFASTFRLLTVFAYGTYADYLAEARNLPPLTDAQK- 93
Query: 194 DKEACLTKIRILSLMTLAAGDTTELSYDTIQKELQLERA-ELEAFVIEAVRQQAVTCKLD 370
K+R LS++TLAA + Y + + L L +LE VIEAV + LD
Sbjct: 94 ------NKLRHLSVVTLAA-KVKCIPYAVLLEALALRNVRQLEDLVIEAVYADVLRGSLD 146
Query: 371 QQNEKVLISGAVPRSFGPDQWTKLYRDLQMWQNNFKIITEDLRKLRSDA 517
Q+N+++ + ++ R + + + LQ W +++ + + S A
Sbjct: 147 QRNQRLEVDYSIGRDIQRQDLSAIAQTLQEWCVGCEVVLSGIEEQVSRA 195
>sp|Q04062|RPN9_YEAST 26S proteasome regulatory subunit RPN9 (Proteasome non-ATPase
subunit 7)
Length = 393
Score = 45.1 bits (105), Expect = 1e-04
Identities = 40/162 (24%), Positives = 73/162 (45%), Gaps = 10/162 (6%)
Frame = +2
Query: 14 VTALQDPNALTMDQILELKPVQCLAGEAIHD-LLSIFVSGTINDYRKFLDDHPDFMEKYE 190
++AL ++L ++ + ++ +D L + + T+ D+ KF D + K +
Sbjct: 219 ISALLGDKIYNFGELLHHPIMETIVNDSNYDWLFQLLNALTVGDFDKF-----DSLIKVQ 273
Query: 191 LDKEACLT--------KIRILSLM-TLAAGDTTELSYDTIQKELQLERAELEAFVIEAVR 343
+ K L KI +++L+ T+ + LS++ I K L + +E V+ A+
Sbjct: 274 ISKIPILAQHESFLRQKICLMTLIETVFVKNIRMLSFEDISKATHLPKDNVEHLVMRAIS 333
Query: 344 QQAVTCKLDQQNEKVLISGAVPRSFGPDQWTKLYRDLQMWQN 469
+ +DQ NE V IS PR DQ TK+ L W +
Sbjct: 334 LGLLKGSIDQVNELVTISWVQPRIISGDQITKMKDRLVEWND 375
>sp|Q6IQT4|CSN2_BRARE COP9 signalosome complex subunit 2 (Signalosome subunit 2)
Length = 443
Score = 35.0 bits (79), Expect = 0.13
Identities = 31/128 (24%), Positives = 61/128 (47%), Gaps = 8/128 (6%)
Frame = +2
Query: 95 AIHDLLSIFVSGTINDYRKFLD-DHPDFMEKYELDK--EACLTKIRILSLMTLAAGDTTE 265
A+ +L+S + + I ++ K L +H + M+ + + E L IR L+ L T
Sbjct: 310 AMTNLVSAYQNNDITEFEKILKTNHSNIMDDPFIREHIEELLRNIRTQVLIKLIK-PYTR 368
Query: 266 LSYDTIQKELQLERAELEAFVIEAVRQQAVTCKLDQQNEKVLI-----SGAVPRSFGPDQ 430
+ I KEL ++ A++E+ +++ + + ++DQ N+ + + GA R D+
Sbjct: 369 IHIPFISKELNIDVADVESLLVQCILDNTINGRIDQVNQLLELDHQKRGGA--RYTALDK 426
Query: 431 WTKLYRDL 454
WT L
Sbjct: 427 WTNQLNSL 434
>sp|P61201|CSN2_HUMAN COP9 signalosome complex subunit 2 (Signalosome subunit 2) (SGN2)
(JAB1-containing signalosome subunit 2) (Thyroid
receptor interacting protein 15) (Alien homolog)
sp|P61203|CSN2_RAT COP9 signalosome complex subunit 2 (Signalosome subunit 2) (SGN2)
(JAB1-containing signalosome subunit 2) (Thyroid
receptor interacting protein 15) (Alien homolog)
sp|P61202|CSN2_MOUSE COP9 signalosome complex subunit 2 (Signalosome subunit 2) (SGN2)
(JAB1-containing signalosome subunit 2) (Thyroid
receptor interacting protein 15) (Alien homolog)
Length = 443
Score = 34.3 bits (77), Expect = 0.22
Identities = 31/128 (24%), Positives = 61/128 (47%), Gaps = 8/128 (6%)
Frame = +2
Query: 95 AIHDLLSIFVSGTINDYRKFLD-DHPDFMEKYELDK--EACLTKIRILSLMTLAAGDTTE 265
A+ +L+S + + I ++ K L +H + M+ + + E L IR L+ L T
Sbjct: 310 AMTNLVSAYQNNDITEFEKILKTNHSNIMDDPFIREHIEELLRNIRTQVLIKLIK-PYTR 368
Query: 266 LSYDTIQKELQLERAELEAFVIEAVRQQAVTCKLDQQNEKVLI-----SGAVPRSFGPDQ 430
+ I KEL ++ A++E+ +++ + + ++DQ N+ + + GA R D+
Sbjct: 369 IHIPFISKELNIDVADVESLLVQCILDNTIHGRIDQVNQLLELDHQKRGGA--RYTALDK 426
Query: 431 WTKLYRDL 454
WT L
Sbjct: 427 WTNQLNSL 434
>sp|Q6IR75|CSN2_XENLA COP9 signalosome complex subunit 2 (Signalosome subunit 2)
Length = 441
Score = 34.3 bits (77), Expect = 0.22
Identities = 31/128 (24%), Positives = 61/128 (47%), Gaps = 8/128 (6%)
Frame = +2
Query: 95 AIHDLLSIFVSGTINDYRKFLD-DHPDFMEKYELDK--EACLTKIRILSLMTLAAGDTTE 265
A+ +L+S + + I ++ K L +H + M+ + + E L IR L+ L T
Sbjct: 308 AMTNLVSAYQNNDITEFEKILKTNHSNIMDDPFIREHIEELLRNIRTQVLIKLIK-PYTR 366
Query: 266 LSYDTIQKELQLERAELEAFVIEAVRQQAVTCKLDQQNEKVLI-----SGAVPRSFGPDQ 430
+ I KEL ++ A++E+ +++ + + ++DQ N+ + + GA R D+
Sbjct: 367 IHIPFISKELNIDVADVESLLVQCILDNTIHGRIDQVNQLLELDHQKRGGA--RYTALDK 424
Query: 431 WTKLYRDL 454
WT L
Sbjct: 425 WTNQLNSL 432
Database: Non-redundant SwissProt sequences
Posted date: Dec 6, 2005 7:40 AM
Number of letters in database: 68,354,980
Number of sequences in database: 184,735
Database: swissprot.01
Posted date: Dec 6, 2005 8:18 AM
Number of letters in database: 66,202,850
Number of sequences in database: 184,431
Lambda K H
0.318 0.134 0.401
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 58,312,641
Number of Sequences: 369166
Number of extensions: 1001780
Number of successful extensions: 2712
Number of sequences better than 10.0: 10
Number of HSP's better than 10.0 without gapping: 2638
Number of HSP's successfully gapped in prelim test: 0
Number of HSP's that attempted gapping in prelim test: 0
Number of HSP's gapped (non-prelim): 2709
length of database: 68,354,980
effective HSP length: 104
effective length of database: 49,142,540
effective search space used: 4127973360
frameshift window, decay const: 40, 0.1
T: 12
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)